Category Archives: nanotechnology

Detect lung cancer early by inhaling a nanosensor

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The technology described in a January 5, 2024 news item on Nanowerk has not been tried in human clinical trials but early pre-clinical trial testing offers promise,

Using a new technology developed at MIT, diagnosing lung cancer could become as easy as inhaling nanoparticle sensors and then taking a urine test that reveals whether a tumor is present.

Key Takeaways

*This non-invasive approach may serve as an alternative or supplement to traditional CT scans, particularly beneficial in areas with limited access to advanced medical equipment.

*The technology focuses on detecting cancer-linked proteins in the lungs, with results obtainable through a simple paper test strip.

*Designed for early-stage lung cancer detection, the method has shown promise in animal models and may soon advance to human clinical trials.

*This innovation holds potential for significantly improving lung cancer screening and early detection, especially in low-resource settings.

…

A January 5, 2024 Massachusetts Institute of Technology (MIT) news release (also on EurkeAlert), which originated the news item, goes on to provide some technical details,

The new diagnostic is based on nanosensors that can be delivered by an inhaler or a nebulizer. If the sensors encounter cancer-linked proteins in the lungs, they produce a signal that accumulates in the urine, where it can be detected with a simple paper test strip.

This approach could potentially replace or supplement the current gold standard for diagnosing lung cancer, low-dose computed tomography (CT). It could have an especially significant impact in low- and middle-income countries that don’t have widespread availability of CT scanners, the researchers say.

“Around the world, cancer is going to become more and more prevalent in low- and middle-income countries. The epidemiology of lung cancer globally is that it’s driven by pollution and smoking, so we know that those are settings where accessibility to this kind of technology could have a big impact,” says Sangeeta Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and of Electrical Engineering and Computer Science at MIT, and a member of MIT’s Koch Institute for Integrative Cancer Research and the Institute for Medical Engineering and Science.

Bhatia is the senior author of the paper, which appears today [January 5, 2024] in Science Advances. Qian Zhong, an MIT research scientist, and Edward Tan, a former MIT postdoc, are the lead authors of the study.

Inhalable particles

To help diagnose lung cancer as early as possible, the U.S. Preventive Services Task Force recommends that heavy smokers over the age of 50 undergo annual CT scans. However, not everyone in this target group receives these scans, and the high false-positive rate of the scans can lead to unnecessary, invasive tests.

Bhatia has spent the last decade developing nanosensors for use in diagnosing cancer and other diseases, and in this study, she and her colleagues explored the possibility of using them as a more accessible alternative to CT screening for lung cancer.

These sensors consist of polymer nanoparticles coated with a reporter, such as a DNA barcode, that is cleaved from the particle when the sensor encounters enzymes called proteases, which are often overactive in tumors. Those reporters eventually accumulate in the urine and are excreted from the body.

Previous versions of the sensors, which targeted other cancer sites such as the liver and ovaries, were designed to be given intravenously. For lung cancer diagnosis, the researchers wanted to create a version that could be inhaled, which could make it easier to deploy in lower resource settings.

“When we developed this technology, our goal was to provide a method that can detect cancer with high specificity and sensitivity, and also lower the threshold for accessibility, so that hopefully we can improve the resource disparity and inequity in early detection of lung cancer,” Zhong says.

To achieve that, the researchers created two formulations of their particles: a solution that can be aerosolized and delivered with a nebulizer, and a dry powder that can be delivered using an inhaler.

Once the particles reach the lungs, they are absorbed into the tissue, where they encounter any proteases that may be present. Human cells can express hundreds of different proteases, and some of them are overactive in tumors, where they help cancer cells to escape their original locations by cutting through proteins of the extracellular matrix. These cancerous proteases cleave DNA barcodes from the sensors, allowing the barcodes to circulate in the bloodstream until they are excreted in the urine.

In the earlier versions of this technology, the researchers used mass spectrometry to analyze the urine sample and detect DNA barcodes. However, mass spectrometry requires equipment that might not be available in low-resource areas, so for this version, the researchers created a lateral flow assay, which allows the barcodes to be detected using a paper test strip.

The researchers designed the strip to detect up to four different DNA barcodes, each of which indicates the presence of a different protease. No pre-treatment or processing of the urine sample is required, and the results can be read about 20 minutes after the sample is obtained.

“We were really pushing this assay to be point-of-care available in a low-resource setting, so the idea was to not do any sample processing, not do any amplification, just to be able to put the sample right on the paper and read it out in 20 minutes,” Bhatia says.

Accurate diagnosis

The researchers tested their diagnostic system in mice that are genetically engineered to develop lung tumors similar to those seen in humans. The sensors were administered 7.5 weeks after the tumors started to form, a time point that would likely correlate with stage 1 or 2 cancer in humans.

In their first set of experiments in the mice, the researchers measured the levels of 20 different sensors designed to detect different proteases. Using a machine learning algorithm to analyze those results, the researchers identified a combination of just four sensors that was predicted to give accurate diagnostic results. They then tested that combination in the mouse model and found that it could accurately detect early-stage lung tumors.

For use in humans, it’s possible that more sensors might be needed to make an accurate diagnosis, but that could be achieved by using multiple paper strips, each of which detects four different DNA barcodes, the researchers say.

The researchers now plan to analyze human biopsy samples to see if the sensor panels they are using would also work to detect human cancers. In the longer term, they hope to perform clinical trials in human patients. A company called Sunbird Bio has already run phase 1 trials on a similar sensor developed by Bhatia’s lab, for use in diagnosing liver cancer and a form of hepatitis known as nonalcoholic steatohepatitis (NASH).

In parts of the world where there is limited access to CT scanning, this technology could offer a dramatic improvement in lung cancer screening, especially since the results can be obtained during a single visit.

“The idea would be you come in and then you get an answer about whether you need a follow-up test or not, and we could get patients who have early lesions into the system so that they could get curative surgery or lifesaving medicines,” Bhatia says.

Here’s a link to and a citation for the paper,

Inhalable point-of-care urinary diagnostic platform by Qian Zhong, Edward K. W. Tan, Carmen Martin-Alonso, Tiziana Parisi, Liangliang Hao, Jesse D. Kirkpatrick, Tarek Fadel, Heather E. Fleming, Tyler Jacks, and Sangeeta N. Bhatia. Science Advances 5 Jan 2024 Vol 10, Issue 1 DOI: 10.1126/sciadv.adj9591

This paper is open access.

Sunbird Bio (the company mentioned in the news release) can be found here.

Resurrection consent for digital cloning of the dead

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It’s a bit disconcerting to think that one might be resurrected, in this case, digitally, but Dr Masaki Iwasaki has helpfully published a study on attitudes to digital cloning and resurrection consent, which could prove helpful when establishing one’s final wishes.

A January 4, 2024 De Gruyter (publisher) press release (repurposed from a January 4, 2024 blog posting on De Gruyter.com) explains the idea and the study,

In a 2014 episode of sci-fi series Black Mirror, a grieving young widow reconnects with her dead husband using an app that trawls his social media history to mimic his online language, humor and personality. It works. She finds solace in the early interactions – but soon wants more.   

Such a scenario is no longer fiction. In 2017, the company Eternime aimed to create an avatar of a dead person using their digital footprint, but this “Skype for the dead” didn’t catch on. The machine-learning and AI algorithms just weren’t ready for it. Neither were we.

Now, in 2024, amid exploding use of Chat GPT-like programs, similar efforts are on the way. But should digital resurrection be allowed at all? And are we prepared for the legal battles over what constitutes consent?

In a study published in the Asian Journal of Law and Economics, Dr Masaki Iwasaki of Harvard Law School and currently an assistant professor at Seoul National University, explores how the deceased’s consent (or otherwise) affects attitudes to digital resurrection.

US adults were presented with scenarios where a woman in her 20s dies in a car accident. A company offers to bring a digital version of her back, but her consent is, at first, ambiguous. What should her friends decide?

Two options – one where the deceased has consented to digital resurrection and another where she hasn’t – were read by participants at random. They then answered questions about the social acceptability of bringing her back on a five-point rating scale, considering other factors such as ethics and privacy concerns.

Results showed that expressed consent shifted acceptability two points higher compared to dissent. “Although I expected societal acceptability for digital resurrection to be higher when consent was expressed, the stark difference in acceptance rates – 58% for consent versus 3% for dissent – was surprising,” says Iwasaki. “This highlights the crucial role of the deceased’s wishes in shaping public opinion on digital resurrection.”

In fact, 59% of respondents disagreed with their own digital resurrection, and around 40% of respondents did not find any kind of digital resurrection socially acceptable, even with expressed consent. “While the will of the deceased is important in determining the societal acceptability of digital resurrection, other factors such as ethical concerns about life and death, along with general apprehension towards new technology are also significant,” says Iwasaki.  

The results reflect a discrepancy between existing law and public sentiment. People’s general feelings – that the dead’s wishes should be respected – are actually not protected in most countries. The digitally recreated John Lennon in the film Forrest Gump, or animated hologram of Amy Winehouse reveal the ‘rights’ of the dead are easily overridden by those in the land of the living.

So, is your digital destiny something to consider when writing your will? It probably should be but in the current absence of clear legal regulations on the subject, the effectiveness of documenting your wishes in such a way is uncertain. For a start, how such directives are respected varies by legal jurisdiction. “But for those with strong preferences documenting their wishes could be meaningful,” says Iwasaki. “At a minimum, it serves as a clear communication of one’s will to family and associates, and may be considered when legal foundations are better established in the future.”

It’s certainly a conversation worth having now. Many generative AI chatbot services, such as like Replika (“The AI companion who cares”) and Project December (“Simulate the dead”) already enable conversations with chatbots replicating real people’s personalities. The service ‘You, Only Virtual’ (YOV) allows users to upload someone’s text messages, emails and voice conversations to create a ‘versona’ chatbot. And, in 2020, Microsoft obtained a patent to create chatbots from text, voice and image data for living people as well as for historical figures and fictional characters, with the option of rendering in 2D or 3D.

Iwasaki says he’ll investigate this and the digital resurrection of celebrities in future research. “It’s necessary first to discuss what rights should be protected, to what extent, then create rules accordingly,” he explains. “My research, building upon prior discussions in the field, argues that the opt-in rule requiring the deceased’s consent for digital resurrection might be one way to protect their rights.”

There is a link to the study in the press release above but this includes a citation, of sorts,

Digital Cloning of the Dead: Exploring the Optimal Default Rule by Masaki Iwasaki. Asian Journal of Law and Economics DOI: https://doi.org/10.1515/ajle-2023-0125 Published Online: 2023-12-27

This paper is open access.

Brainlike transistor and human intelligence

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This brainlike transistor (not a memristor) is important because it functions at room temperature as opposed to others, which require cryogenic temperatures.

A December 20, 2023 Northwestern University news release (received via email; also on EurekAlert) fills in the details,

  • Researchers develop transistor that simultaneously processes and stores information like the human brain
  • Transistor goes beyond categorization tasks to perform associative learning
  • Transistor identified similar patterns, even when given imperfect input
  • Previous similar devices could only operate at cryogenic temperatures; new transistor operates at room temperature, making it more practical

EVANSTON, Ill. — Taking inspiration from the human brain, researchers have developed a new synaptic transistor capable of higher-level thinking.

Designed by researchers at Northwestern University, Boston College and the Massachusetts Institute of Technology (MIT), the device simultaneously processes and stores information just like the human brain. In new experiments, the researchers demonstrated that the transistor goes beyond simple machine-learning tasks to categorize data and is capable of performing associative learning.

Although previous studies have leveraged similar strategies to develop brain-like computing devices, those transistors cannot function outside cryogenic temperatures. The new device, by contrast, is stable at room temperatures. It also operates at fast speeds, consumes very little energy and retains stored information even when power is removed, making it ideal for real-world applications.

The study was published today (Dec. 20 [2023]) in the journal Nature.

“The brain has a fundamentally different architecture than a digital computer,” said Northwestern’s Mark C. Hersam, who co-led the research. “In a digital computer, data move back and forth between a microprocessor and memory, which consumes a lot of energy and creates a bottleneck when attempting to perform multiple tasks at the same time. On the other hand, in the brain, memory and information processing are co-located and fully integrated, resulting in orders of magnitude higher energy efficiency. Our synaptic transistor similarly achieves concurrent memory and information processing functionality to more faithfully mimic the brain.”

Hersam is the Walter P. Murphy Professor of Materials Science and Engineering at Northwestern’s McCormick School of Engineering. He also is chair of the department of materials science and engineering, director of the Materials Research Science and Engineering Center and member of the International Institute for Nanotechnology. Hersam co-led the research with Qiong Ma of Boston College and Pablo Jarillo-Herrero of MIT.

Recent advances in artificial intelligence (AI) have motivated researchers to develop computers that operate more like the human brain. Conventional, digital computing systems have separate processing and storage units, causing data-intensive tasks to devour large amounts of energy. With smart devices continuously collecting vast quantities of data, researchers are scrambling to uncover new ways to process it all without consuming an increasing amount of power. Currently, the memory resistor, or “memristor,” is the most well-developed technology that can perform combined processing and memory function. But memristors still suffer from energy costly switching.

“For several decades, the paradigm in electronics has been to build everything out of transistors and use the same silicon architecture,” Hersam said. “Significant progress has been made by simply packing more and more transistors into integrated circuits. You cannot deny the success of that strategy, but it comes at the cost of high power consumption, especially in the current era of big data where digital computing is on track to overwhelm the grid. We have to rethink computing hardware, especially for AI and machine-learning tasks.”

To rethink this paradigm, Hersam and his team explored new advances in the physics of moiré patterns, a type of geometrical design that arises when two patterns are layered on top of one another. When two-dimensional materials are stacked, new properties emerge that do not exist in one layer alone. And when those layers are twisted to form a moiré pattern, unprecedented tunability of electronic properties becomes possible.

For the new device, the researchers combined two different types of atomically thin materials: bilayer graphene and hexagonal boron nitride. When stacked and purposefully twisted, the materials formed a moiré pattern. By rotating one layer relative to the other, the researchers could achieve different electronic properties in each graphene layer even though they are separated by only atomic-scale dimensions. With the right choice of twist, researchers harnessed moiré physics for neuromorphic functionality at room temperature.

“With twist as a new design parameter, the number of permutations is vast,” Hersam said. “Graphene and hexagonal boron nitride are very similar structurally but just different enough that you get exceptionally strong moiré effects.”

To test the transistor, Hersam and his team trained it to recognize similar — but not identical — patterns. Just earlier this month, Hersam introduced a new nanoelectronic device capable of analyzing and categorizing data in an energy-efficient manner, but his new synaptic transistor takes machine learning and AI one leap further.

“If AI is meant to mimic human thought, one of the lowest-level tasks would be to classify data, which is simply sorting into bins,” Hersam said. “Our goal is to advance AI technology in the direction of higher-level thinking. Real-world conditions are often more complicated than current AI algorithms can handle, so we tested our new devices under more complicated conditions to verify their advanced capabilities.”

First the researchers showed the device one pattern: 000 (three zeros in a row). Then, they asked the AI to identify similar patterns, such as 111 or 101. “If we trained it to detect 000 and then gave it 111 and 101, it knows 111 is more similar to 000 than 101,” Hersam explained. “000 and 111 are not exactly the same, but both are three digits in a row. Recognizing that similarity is a higher-level form of cognition known as associative learning.”

In experiments, the new synaptic transistor successfully recognized similar patterns, displaying its associative memory. Even when the researchers threw curveballs — like giving it incomplete patterns — it still successfully demonstrated associative learning.

“Current AI can be easy to confuse, which can cause major problems in certain contexts,” Hersam said. “Imagine if you are using a self-driving vehicle, and the weather conditions deteriorate. The vehicle might not be able to interpret the more complicated sensor data as well as a human driver could. But even when we gave our transistor imperfect input, it could still identify the correct response.”

The study, “Moiré synaptic transistor with room-temperature neuromorphic functionality,” was primarily supported by the National Science Foundation.

Here’s a link to and a citation for the paper,

Moiré synaptic transistor with room-temperature neuromorphic functionality by Xiaodong Yan, Zhiren Zheng, Vinod K. Sangwan, Justin H. Qian, Xueqiao Wang, Stephanie E. Liu, Kenji Watanabe, Takashi Taniguchi, Su-Yang Xu, Pablo Jarillo-Herrero, Qiong Ma & Mark C. Hersam. Nature volume 624, pages 551–556 (2023) DOI: https://doi.org/10.1038/s41586-023-06791-1 Published online: 20 December 2023 Issue Date: 21 December 2023

This paper is behind a paywall.

Transformative potential of Martian nanomaterials

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Yes, nanomaterials from Mars! A December 21, 2023 news item on Nanowerk makes the proposition, Note: A link has been removed,

Researchers at the University of Sussex have discovered the transformative potential of Martian nanomaterials, potentially opening the door to sustainable habitation on the red planet. They published their findings in (“Quasi–1D Anhydrite Nanobelts from the Sustainable Liquid Exfoliation of Terrestrial Gypsum for Future Martian-Based Electronics”).

Using resources and techniques currently applied on the International Space Station [ISS] and by NASA [US National Aeronautics and Space Administration], Dr Conor Boland, a Lecturer in Materials Physics at the University of Sussex, led a research group that investigated the potential of nanomaterials – incredibly tiny components thousands of times smaller than a human hair – for clean energy production and building materials on Mars.

Taking what was considered a waste product by NASA and applying only sustainable production methods, including water-based chemistry and low-energy processes, the researchers have successfully identified electrical properties within gypsum nanomaterials – opening the door to potential clean energy and sustainable technology production on Mars.

…

A December 21, 2023 University of Sussex press release (also on EurekAlert) by Stephanie Allen, which originated the news item, features the lead researcher’s hopes for the discovery, Note: A link has been removed,

Dr Conor Boland, said: 

“This study shows that the potential is quite literally out of this world for nanomaterials. Our study builds off recent research performed by NASA and takes what was considered waste, essentially lumps of rock, and turns it into transformative nanomaterials for a range of applications from creating clean hydrogen fuel to developing an electronic device similar to a transistor, to creating an additive to textiles to increase their robustness.

“This opens avenues for sustainable technology – and building – on Mars but also highlights the broader potential for eco-friendly breakthroughs here on Earth.”

To make the breakthrough the researchers used NASA’s innovative method for extracting water from Martian gypsum, which is dehydrated by the agency to get water for human consumption. This produces a byproduct called anhydrite—considered waste material by NASA, but now shown to be hugely valuable.

The Sussex researchers processed anhydrite into nanobelts –  essentially tagliatelle-shaped materials – demonstrating their potential to provide clean energy and sustainable electronics. Furthermore, at every step of their process, water could be continuously collected and recycled.

Dr Boland added: 

“We are optimistic of the feasibility of this process on Mars, as it requires only naturally occurring materials – everything we used could, in theory, be replicated on the red planet. Arguably this is the most important goal in making the Martian colony sustainable from the outset.”

While full-scale electronics production may be impractical on Mars due to the lack of clean rooms and sterile conditions, the anhydrite nanobelts hold promise for clean energy production on Earth, and could, later down the line, still have a profound effect on sustainable energy production on Mars.

Here’s what a Martian nanomaterial looks like,

Caption: Two raw rocks used by the researchers (left). Vials show the nanobelts in water, with a close up of the actual nanobelts (right). Credit: University of Sussex

Here’s a link to and a citation for the paper,

Quasi–1D Anhydrite Nanobelts from the Sustainable Liquid Exfoliation of Terrestrial Gypsum for Future Martian-Based Electronics by Cencen Wei, Abhijit Roy, Adel K. A. Aljarid, Yi Hu, S. Mark Roe, Dimitrios G. Papageorgiou, Raul Arenal, Conor S. Boland. Advanced Functional Materials DOI: https://doi.org/10.1002/adfm.202310600 First published: 14 December 2023

This paper is open access.

Brain-inspired (neuromrophic) computing with twisted magnets and a patent for manufacturing permanent magnets without rare earths

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I have two news bits both of them concerned with magnets.

Patent for magnets that can be made without rare earths

I’m starting with the patent news first since this is (as the company notes in its news release) a “Landmark Patent Issued for Technology Critically Needed to Combat Chinese Monopoly.”

For those who don’t know, China supplies most of the rare earths used in computers, smart phones, and other devices. On general principles, having a single supplier dominate production of and access to a necessary material for devices that most of us rely on can raise tensions. Plus, you can’t mine for resources forever.

This December 19, 2023 Nanocrystal Technology LP news release heralds an exciting development (for the impatient, further down the page I have highlighted the salient sections),

Nanotechnology Discovery by 2023 Nobel Prize Winner Became Launch Pad to Create Permanent Magnets without Rare Earths from China

NEW YORK, NY, UNITED STATES, December 19, 2023 /EINPresswire.com/ — Integrated Nano-Magnetics Corp, a wholly owned subsidiary of Nanocrystal Technology LP, was awarded a patent for technology built upon a fundamental nanoscience discovery made by Aleksey Yekimov, its former Chief Scientific Officer.

This patent will enable the creation of strong permanent magnets which are critically needed for both industrial and military applications but cannot be manufactured without certain “rare earth” elements available mostly from China.

At a glittering awards ceremony held in Stockholm on December10, 2023, three scientists, Aleksey Yekimov, Louis Brus (Professor at Columbia University) and Moungi Bawendi (Professor at MIT) were honored with the Nobel Prize in Chemistry for their discovery of the “quantum dot” which is now fueling practical applications in tuning the colors of LEDs, increasing the resolution of TV screens, and improving MRI imaging.

As stated by the Royal Swedish Academy of Sciences, “Quantum dots are … bringing the greatest benefits to humankind. Researchers believe that in the future they could contribute to flexible electronics, tiny sensors, thinner solar cells, and encrypted quantum communications – so we have just started exploring the potential of these tiny particles.”

Aleksey Yekimov worked for over 19 years until his retirement as Chief Scientific Officer of Nanocrystals Technology LP, an R & D company in New York founded by two Indian-American entrepreneurs, Rameshwar Bhargava and Rajan Pillai.

Yekimov, who was born in Russia, had already received the highest scientific honors for his work before he immigrated to USA in 1999. Yekimov was greatly intrigued by Nanocrystal Technology’s research project and chose to join the company as its Chief Scientific Officer.

During its early years, the company worked on efficient light generation by doping host nanoparticles about the same size as a quantum dot with an additional impurity atom. Bhargava came up with the novel idea of incorporating a single impurity atom, a dopant, into a quantum dot sized host, and thus achieve an extraordinary change in the host material’s properties such as inducing strong permanent magnetism in weak, readily available paramagnetic materials. To get a sense of the scale at which nanotechnology works, and as vividly illustrated by the Nobel Foundation, the difference in size between a quantum dot and a soccer ball is about the same as the difference between a soccer ball and planet Earth.

Currently, strong permanent magnets are manufactured from “rare earths” available mostly in China which has established a near monopoly on the supply of rare-earth based strong permanent magnets. Permanent magnets are a fundamental building block for electro-mechanical devices such as motors found in all automobiles including electric vehicles, trucks and tractors, military tanks, wind turbines, aircraft engines, missiles, etc. They are also required for the efficient functioning of audio equipment such as speakers and cell phones as well as certain magnetic storage media.

The existing market for permanent magnets is $28 billion and is projected to reach $50 billion by 2030 in view of the huge increase in usage of electric vehicles. China’s overwhelming dominance in this field has become a matter of great concern to governments of all Western and other industrialized nations. As the Wall St. Journal put it, China’s now has a “stranglehold” on the economies and security of other countries.

The possibility of making permanent magnets without the use of any rare earths mined in China has intrigued leading physicists and chemists for nearly 30 years. On December 19, 2023, a U.S. patent with the title ‘’Strong Non Rare Earth Permanent Magnets from Double Doped Magnetic Nanoparticles” was granted to Integrated Nano-Magnetics Corp. [emphasis mine] Referring to this major accomplishment Bhargava said, “The pioneering work done by Yekimov, Brus and Bawendi has provided the foundation for us to make other discoveries in nanotechnology which will be of great benefit to the world.”

I was not able to find any company websites. The best I could find is a Nanocrystals Technology LinkedIn webpage and some limited corporate data for Integrated Nano-Magnetics on opencorporates.com.

Twisted magnets and brain-inspired computing

This research offers a pathway to neuromorphic (brainlike) computing with chiral (or twisted) magnets, which, as best as I understand it, do not require rare earths. From a November13, 2023 news item on ScienceDaily,

A form of brain-inspired computing that exploits the intrinsic physical properties of a material to dramatically reduce energy use is now a step closer to reality, thanks to a new study led by UCL [University College London] and Imperial College London [ICL] researchers.

In the new study, published in the journal Nature Materials, an international team of researchers used chiral (twisted) magnets as their computational medium and found that, by applying an external magnetic field and changing temperature, the physical properties of these materials could be adapted to suit different machine-learning tasks.

…

A November 9, 2023 UCL press release (also on EurekAlert but published November 13, 2023), which originated the news item, fill s in a few more details about the research,

Dr Oscar Lee (London Centre for Nanotechnology at UCL and UCL Department of Electronic & Electrical Engineering), the lead author of the paper, said: “This work brings us a step closer to realising the full potential of physical reservoirs to create computers that not only require significantly less energy, but also adapt their computational properties to perform optimally across various tasks, just like our brains.

“The next step is to identify materials and device architectures that are commercially viable and scalable.”

Traditional computing consumes large amounts of electricity. This is partly because it has separate units for data storage and processing, meaning information has to be shuffled constantly between the two, wasting energy and producing heat. This is particularly a problem for machine learning, which requires vast datasets for processing. Training one large AI model can generate hundreds of tonnes of carbon dioxide.

Physical reservoir computing is one of several neuromorphic (or brain inspired) approaches that aims to remove the need for distinct memory and processing units, facilitating more efficient ways to process data. In addition to being a more sustainable alternative to conventional computing, physical reservoir computing could be integrated into existing circuitry to provide additional capabilities that are also energy efficient.

In the study, involving researchers in Japan and Germany, the team used a vector network analyser to determine the energy absorption of chiral magnets at different magnetic field strengths and temperatures ranging from -269 °C to room temperature.

They found that different magnetic phases of chiral magnets excelled at different types of computing task. The skyrmion phase, where magnetised particles are swirling in a vortex-like pattern, had a potent memory capacity apt for forecasting tasks. The conical phase, meanwhile, had little memory, but its non-linearity was ideal for transformation tasks and classification – for instance, identifying if an animal is a cat or dog.

Co-author Dr Jack Gartside, of Imperial College London, said: “Our collaborators at UCL in the group of Professor Hidekazu Kurebayashi recently identified a promising set of materials for powering unconventional computing. These materials are special as they can support an especially rich and varied range of magnetic textures. Working with the lead author Dr Oscar Lee, the Imperial College London group [led by Dr Gartside, Kilian Stenning and Professor Will Branford] designed a neuromorphic computing architecture to leverage the complex material properties to match the demands of a diverse set of challenging tasks. This gave great results, and showed how reconfiguring physical phases can directly tailor neuromorphic computing performance.”

The work also involved researchers at the University of Tokyo and Technische Universität München and was supported by the Leverhulme Trust, Engineering and Physical Sciences Research Council (EPSRC), Imperial College London President’s Excellence Fund for Frontier Research, Royal Academy of Engineering, the Japan Science and Technology Agency, Katsu Research Encouragement Award, Asahi Glass Foundation, and the DFG (German Research Foundation).

Here’s a link to and a citation for the paper,

Task-adaptive physical reservoir computing by Oscar Lee, Tianyi Wei, Kilian D. Stenning, Jack C. Gartside, Dan Prestwood, Shinichiro Seki, Aisha Aqeel, Kosuke Karube, Naoya Kanazawa, Yasujiro Taguchi, Christian Back, Yoshinori Tokura, Will R. Branford & Hidekazu Kurebayashi. Nature Materials volume 23, pages 79–87 (2024) DOI: https://doi.org/10.1038/s41563-023-01698-8 Published online: 13 November 2023 Issue Date: January 2024

This paper is open access.

Collaborative research agreement (CRA) with McMaster University (Canada) for development of catheter coating

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I don’t always do as good a job at covering the commercialization of emerging technologies as I’d like, so, this December 13, 2023 news item on Yahoo News was a welcome discovery,

Oakville, Ontario–(Newsfile Corp. – December 13, 2023) – FendX Technologies Inc. (CSE: FNDX) (OTCQB: FDXTF) (FSE: E8D) (the “Company” or “FendX“), a nanotechnology company developing surface protection coatings is pleased to announce it has entered into a Collaborative Research Agreement (“CRA“) dated December 12, 2023 with McMaster University (“McMaster“) which details the research and development plan to create a protective catheter coating using our nanotechnology licensed pursuant to the license agreement dated February 5, 2021, as amended, between the Company and McMaster.

Dr. Carolyn Myers, President and CEO of FendX, stated, “We are excited about the prospect of developing a coating for catheters using our nanotechnology which we believe will reduce catheter blockage caused by either blood clots or bacterial biofilms. Early work conducted at McMaster has demonstrated significant reduction in the adherence of both bacteria and blood which could potentially translate to reduced bacterial biofilm or blood clot formation. [emphasis mine] Our aim is to further this research to tackle the medical need to reduce catheter blockage rates, which can be costly and interfere with patient therapy. We anticipate the development of this coating formulation will also strengthen our overall intellectual property portfolio.”

The CRA outlines more fully the research and development work to be conducted by McMaster on behalf of FendX as well as a payment schedule for the maximum research funding requirements. The term of the CRA is for 24 months commencing on the effective date of December 1, 2023, unless terminated in accordance with the provisions of the CRA. In the first and second year, maximum research funding to McMaster will be $150,547 each year.

About FendX Technologies Inc.

FendX is a Canada-based nanotechnology company focused on developing products to make people’s lives safer by reducing the spread of pathogens. The Company is developing both film and spray products to protect surfaces from contamination. The lead product under development, REPELWRAP™ film, is a protective surface coating film that, due to its repelling properties, prevents the adhesion of pathogens and reduces their transmission on surfaces prone to contamination. The spray nanotechnology is a bifunctional spray coating being developed to reduce contamination on surfaces by repelling and killing pathogens. The Company is conducting research and development activities using its nanotechnology in collaboration with industry-leading partners, including McMaster University. The Company has an exclusive worldwide license to its technology and IP portfolio from McMaster, which encompass both film and spray coating nanotechnology formulations.

…

For more information, please visit https://fendxtech.com/ and the Company’s profile on SEDAR+ at www.sedarplus.ca.

Neither the Canadian Securities Exchange nor the Market Regulator (as that term is defined in the policies of the Canadian Securities Exchange) accepts responsibility for the adequacy or accuracy of this release.

Forward-Looking Statements

This news release contains certain forward-looking statements within the meaning of Canadian securities legislation, including with respect to: the plans of the Company; statements regarding the catheter coating development and anticipated benefits; the Company’s belief that the catheter coating could reduce catheter occlusions caused by either blood clots or bacterial biofilms; statements regarding strengthening the Company’s overall intellectual property portfolio; the Company’s belief that REPELWRAP™ will have applications in healthcare settings and other industries; and products under development and any pathogen reduction benefits related thereto. Although the Company believes that such statements are reasonable, it can give no assurance that such expectations will prove to be correct. Forward-looking statements are statements that are not historical facts; they are generally, but not always, identified by the words “expects,” “plans,” “anticipates,” “believes,” “intends,” “estimates,” “projects,” “aims,” “potential,” “goal,” “objective,” “prospective,” and similar expressions, or that events or conditions “will,” “would,” “may,” “can,” “could” or “should” occur, or are those statements, which, by their nature, refer to future events. The Company cautions that forward-looking statements are based on the beliefs, estimates and opinions of the Company’s management on the date the statements are made and involve several risks and uncertainties. Consequently, there can be no assurances that such statements will prove to be accurate and that actual results and future events could differ materially from those anticipated in such statements.

Important factors that could cause future results to differ materially from those anticipated in these forward-looking statements include: product candidates only being in formulation/reformulation stages; limited operating history; research and development activities; dependence on collaborative partners, licensors and others; effect of general economic and political conditions; and other risk factors set forth in the Company’s public filings which are available on SEDAR+ at www.sedarplus.ca. Accordingly, the reader is urged to refer to the Company’s such filings for a more complete discussion of such risk factors and their potential effects. Except to the extent required by applicable securities laws and the policies of the Canadian Securities Exchange, the Company undertakes no obligation to update these forward-looking statements if management’s beliefs, estimates or opinions, or other factors should change.

FendX offers next to no information about their technology or the proposed work with McMaster as seen in this excerpt from the Our Technology webpage on the FendX website,

Our patent-pending licensed nanotechnology works by combining a hierarchical wrinkled molecular structure with chemical functionalization to create nano-surfaces with repelling properties that prevent adhesion of bacteria, viruses and liquids.

Inspired by the water-resistant surface of the lotus leaf

Our nanotechnology causes both high surface tension (e.g., water) and low surface tension (e.g., oil) liquids to form droplets when they come in contact with the nano-surface.

The repelling properties of our nano-surfaces prevents adhesion of bacteria and viruses.

We believe our technology will have numerous applications and opportunities in healthcare and other industries.

That’s it. No technical details and not a single research study is cited.

While McMaster University doesn’t seem to have issued any news releases about their joint research effort with FendX, there are two research papers that I’m reasonably confident are relevant. From the Didar Lab Publications webpage, here are links and citation for both papers,

An omniphobic lubricant-infused coating produced by chemical vapor deposition of hydrophobic organosilanes attenuates clotting on catheter surfaces by Maryam Badv, Iqbal H. Jaffer, Jeffrey I. Weitz & Tohid F. Didar. Scientific Reports volume 7, Article number: 11639 (2017) DOI: https://doi.org/10.1038/s41598-017-12149-1 Published: 14 September 2017

This paper is open access.

Highly Stable Hierarchically Structured All-Polymeric Lubricant-Infused Films Prevent Thrombosis and Repel Multidrug-Resistant Pathogens by Elisabet Afonso, Fereshteh Bayat, Liane Ladouceur, Shadman Khan, Aránzazu Martínez-Gómez, Jeffrey I. Weitz, Zeinab Hosseinidoust, Pilar Tiemblo, Nuria García, and Tohid F. Didar. CS Appl. Mater. Interfaces 2022, 14, 48, 53535–53545 DOI: https://doi.org/10.1021/acsami.2c17309 Publication Date: November 22, 2022 Copyright © 2022 American Chemical Society

This paper is behind a paywall.

Interweave: A multi-sensory show (March 21, 2024 in Vancouver, Canada) where fashion, movement, & music come together though wearable instruments.

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Interweave is a free show at The Kent in the gallery in downtown Vancouver, Canada. Here’s more from a Simon Fraser University (SFU) announcement (received via email),

SFU School for the Contemporary Arts (SCA) alumnus, Kimia Koochakzadeh-Yazdi, is hosting Interweave, a multi-sensory show where fashion, movement, and music come together though wearable instruments.

Embrace the fusion of creativity and expression alongside your fellow alumni in a setting that celebrates innovation and the uncharted synergy between fashion, music, and movement. This is a great opportunity to mingle and reconnect with your peers.

Event Details:

Date: March 21, 2024
Time: Doors 7:30pm, Show 8:00pm
Location: The Kent Vancouver, 534 Cambie Street
Free Entry, RSVP required

Interweave is the first event from Fashion x Electronics (FXE), a collective created by Kimia Koochakzadeh-Yazdi, SCA alumnus, composer, and performer, and designer Kayla Yazdi. FXE is an interdisciplinary collective that is building multi-sensory experiences for their community, bridging together a diverse range of disciplines.

This is a 19+ event. ID will be checked at the door.

RSVP Now!

I wasn’t able to discern much more about the event or the Yazdi sisters from their Fashion x Electronics (FXE) website but there is this about Kayla Yazdi on her FXE profile,

Kayla Yazdi

Designer / Co-Producer

Kayla Yazdi is an Iranian-Canadian designer based in Vancouver, Canada. Her upbringing in Iran immersed her in a world of culture, art, and color. Holding a diploma in painting and a bachelor’s degree in design with a specialization in fashion and technology, Kayla has cultivated the skill set that merges her artistic sensibilities with innovative design concepts.

Kayla is dedicated to the creation of “almost” zero-waste garments. With design, technology, and experimentation, Kayla seeks to minimize environmental impacts while delivering unique styles.

Kimia Koochakzadeh-Yazdi’s FXE profile has this,

Kimia Koochakzadeh-Yazdi

Sound Artist / Co-Producer

Kimia Koochakzadeh-Yazdi(b. 1997 Tehran, Iran) is a California/Vancouver-based composer and performer. She writes for hybrid instrumental/electronic ensembles, creates electroacoustic and audiovisual works, and performs electronic music. Kimia explores the unfamiliar familiar while constantly being driven by the concepts of motion, interaction, and growth in both human life and in the sonic world. Being a cross-disciplinary artist, she has actively collaborated on projects evolving around dance, film, and theatre. Kimia’s work has been showcased by organizations such as Iranian Female Composer Association, Music on Main, Western Front, Vancouver New Music, and Media Arts Committee. She has been featured in The New York Times, Georgia Straight, MusicWorks Magazine, Vancouver Sun, and Sequenza 21. Her work has been performed at festivals around the world including Ars Electronica Festival, Festival Ecos Urbanos, Tehran Contemporary Sounds, AudioVisual Frontiers Virtual Exhibition, The New York City Electroacoustic Music Festival, Yarn/Wire Institute, Ensemble Evolution, New Music on the Point, wasteLAnd Summer Academy, EQ: Evolution of the String Quartet, Modulus Festival, and SALT New Music Festival. She holds a BFA in Music Composition from Simon Fraser University’s Interdisciplinary School for the Contemporary Arts, having studied with Sabrina Schroeder and Mauricio Pauly. Kimia is currently pursuing her DMA in Music Composition at Stanford University.

For more details about the sisters and the performance, Marilyn R. Wilson has written up a February 21, 2024 interview with both sisters for her Olio blog,

Can you share a little bit about your background, the life, work, experiences that led you to who you are today?
Kayla: I’m a visual artist with a focus on fashion design, and textile development. I like to explore ways to create wearable art with minimal waste produced in the process. I studied painting at Azadehgan School of Art in Iran and fashion design & technology at Wilson School of Design in Vancouver. My interest in fashion is rooted in creating functional art. I enjoy the business aspect of fashion however, I want to push boundaries of how fashion can be seen as art rather than solely as production.

Kimia: I’m a composer of acoustic and electronic music, I perform and build instruments, and a lot of times I combine these components together. Working with various disciplines is also an important part of my practice. I studied piano performance at Tehran Music School before moving to Vancouver to study composition at Simon Fraser University. I am currently a doctorate candidate in music composition at Stanford University. I love electronic music, food, and sports! My family, partner, and friends are a huge part of my life!

…

You have your premier event called “Interweave” coming up on March 21st at The Kent Gallery in Vancouver. What can guests attending expect this evening?

Kayla & Kimia: Interweave is a multidisciplinary performance that bridges fashion, music, technology, and dance. Our dancers will be performing in garments designed by Kayla, that are embedded with microcontrollers and sensors developed by Kimia. The dancers control various musical parameters through their movements and their interaction with the sensors that are incorporated within the garments. Along with works for movement and dance, there will be a live electronic music performance made for costume-made instruments. So far we have received an amazing amount of support and RSVP’s from the art industry in Vancouver and look forward to welcoming many local creative individuals.

We’d love to know about the team of professionals who are working hard to create this unique experience. 

Kayla & Kimia: We are working with the amazing choreographers/dancers Anya Saugstad and Daria Mikhailiuk. We are thankful for Laleh Zandi’s help for creating a sculpture for one of our instruments which will be performed by Kimia. Celeste Betancur and Richard Lee have been our amazing audio tech assistants. We are very appreciative of everyone involved in FXE’s premiere and can’t wait to showcase our hard work.

…

I have a bit more about Kimia Koochakzadeh-Yazdi and her work in music from a February 27, 2024 profile on the SFU School for the Contemporary Arts website, Note: Links have been removed,

Please introduce yourself.

I’m a composer of acoustic and electronic music, I perform and build instruments, and a lot of times, I combine these components together. Working with various disciplines is also an important part of my practice. I studied piano performance at Tehran Music School before moving to Vancouver to study composition at Simon Fraser University, graduating from the SCA in 2020. I am currently a doctoral student in music composition at Stanford University, where I spend most of my time.

…

Tell us about your current studies.

I’m in the third year of the DMA (Doctor of Musical Arts) program at Stanford University. I do the majority of my work at the Center for Computer Research in Music and Acoustics (CCRMA). I’m currently trying to learn and to experiment as much as possible! The amount of resources and ideas that I have been exposed to during the last couple of years has been quite significant and wonderful. I have been taking courses in subjects that I never thought I would study, from classes in the computer science and the mechanical engineering departments, to ones in education and theatre. I’m grateful to have been given a supportive platform to truly experiment and to learn.

As for my compositions, they are more melodic than before, and that currently makes me happy. I have started to perform more again (piano and electronics), and it makes me question: why did I ever stop…?

…

Koochakzadeh-Yazdi’s mention of building instruments reminded me of Icelandic musician, Bjork and Biophilia, which was an album, various art projects, and a film (Biophilia Live), which featured a number of musical instruments she created.

Getting back to Interweave, it’ s on March 21, 2024 at The Kent, specifically the gallery, which has,

… 14 foot ceilings boasts 50 track lights with the ability to transform the vacuous hall from candlelight to daylight. The lights are fully dimmable in an array of playful hues, according to your whim.   A full array of DMX Lighting and control systems live alongside the track light system and our recently installed (Vancouvers only) immersive projection system [emphasis mine] is ready for your vision.  This is your show.

I wonder if ‘multi-sensory’ includes an immersive experience.

Don’t forget, you have to RSVP for Interweave, which is free.