Monthly Archives: November 2018

Electrode-filled elastic fiber for wearable electronics and robots

This work comes out of Switzerland. A May 25, 2018 École Polytechnique Fédérale de Lausanne (EPFL) press release (also on EurekAlert) announces their fibers,

EPFL scientists have found a fast and simple way to make super-elastic, multi-material, high-performance fibers. Their fibers have already been used as sensors on robotic fingers and in clothing. This breakthrough method opens the door to new kinds of smart textiles and medical implants.

It’s a whole new way of thinking about sensors. The tiny fibers developed at EPFL are made of elastomer and can incorporate materials like electrodes and nanocomposite polymers. The fibers can detect even the slightest pressure and strain and can withstand deformation of close to 500% before recovering their initial shape. All that makes them perfect for applications in smart clothing and prostheses, and for creating artificial nerves for robots.

The fibers were developed at EPFL’s Laboratory of Photonic Materials and Fiber Devices (FIMAP), headed by Fabien Sorin at the School of Engineering. The scientists came up with a fast and easy method for embedding different kinds of microstructures in super-elastic fibers. For instance, by adding electrodes at strategic locations, they turned the fibers into ultra-sensitive sensors. What’s more, their method can be used to produce hundreds of meters of fiber in a short amount of time. Their research has just been published in Advanced Materials.

Heat, then stretch
To make their fibers, the scientists used a thermal drawing process, which is the standard process for optical-fiber manufacturing. They started by creating a macroscopic preform with the various fiber components arranged in a carefully designed 3D pattern. They then heated the preform and stretched it out, like melted plastic, to make fibers of a few hundreds microns in diameter. And while this process stretched out the pattern of components lengthwise, it also contracted it crosswise, meaning the components’ relative positions stayed the same. The end result was a set of fibers with an extremely complicated microarchitecture and advanced properties.

Until now, thermal drawing could be used to make only rigid fibers. But Sorin and his team used it to make elastic fibers. With the help of a new criterion for selecting materials, they were able to identify some thermoplastic elastomers that have a high viscosity when heated. After the fibers are drawn, they can be stretched and deformed but they always return to their original shape.

Rigid materials like nanocomposite polymers, metals and thermoplastics can be introduced into the fibers, as well as liquid metals that can be easily deformed. “For instance, we can add three strings of electrodes at the top of the fibers and one at the bottom. Different electrodes will come into contact depending on how the pressure is applied to the fibers. This will cause the electrodes to transmit a signal, which can then be read to determine exactly what type of stress the fiber is exposed to – such as compression or shear stress, for example,” says Sorin.

Artificial nerves for robots

Working in association with Professor Dr. Oliver Brock (Robotics and Biology Laboratory, Technical University of Berlin), the scientists integrated their fibers into robotic fingers as artificial nerves. Whenever the fingers touch something, electrodes in the fibers transmit information about the robot’s tactile interaction with its environment. The research team also tested adding their fibers to large-mesh clothing to detect compression and stretching. “Our technology could be used to develop a touch keyboard that’s integrated directly into clothing, for instance” says Sorin.

The researchers see many other potential applications. Especially since the thermal drawing process can be easily tweaked for large-scale production. This is a real plus for the manufacturing sector. The textile sector has already expressed interest in the new technology, and patents have been filed.

There’s a video of the lead researcher discussing the work as he offers some visual aids,

Here’s a link to and a citation for the paper,

Superelastic Multimaterial Electronic and Photonic Fibers and Devices via Thermal Drawing by Yunpeng Qu, Tung Nguyen‐Dang, Alexis Gérald Page, Wei Yan, Tapajyoti Das Gupta, Gelu Marius Rotaru, René M. Rossi, Valentine Dominique Favrod, Nicola Bartolomei, Fabien Sorin. Advanced Materials First published: 25 May 2018 https://doi.org/10.1002/adma.201707251

This paper is behind a paywall.

Transparent graphene electrode technology and complex brain imaging

Michael Berger has written a May 24, 2018 Nanowerk Spotlight article about some of the latest research on transparent graphene electrode technology and the brain (Note: A link has been removed),

In new work, scientists from the labs of Kuzum [Duygu Kuzum, an Assistant Professor of Electrical and Computer Engineering at the University of California, San Diego {UCSD}] and Anna Devor report a transparent graphene microelectrode neural implant that eliminates light-induced artifacts to enable crosstalk-free integration of 2-photon microscopy, optogenetic stimulation, and cortical recordings in the same in vivo experiment. The new class of transparent brain implant is based on monolayer graphene. It offers a practical pathway to investigate neuronal activity over multiple spatial scales extending from single neurons to large neuronal populations.

Conventional metal-based microelectrodes cannot be used for simultaneous measurements of multiple optical and electrical parameters, which are essential for comprehensive investigation of brain function across spatio-temporal scales. Since they are opaque, they block the field of view of the microscopes and generate optical shadows impeding imaging.

More importantly, they cause light induced artifacts in electrical recordings, which can significantly interfere with neural signals. Transparent graphene electrode technology presented in this paper addresses these problems and allow seamless and crosstalk-free integration of optical and electrical sensing and manipulation technologies.

In their work, the scientists demonstrate that by careful design of key steps in the fabrication process for transparent graphene electrodes, the light-induced artifact problem can be mitigated and virtually artifact-free local field potential (LFP) recordings can be achieved within operating light intensities.

“Optical transparency of graphene enables seamless integration of imaging, optogenetic stimulation and electrical recording of brain activity in the same experiment with animal models,” Kuzum explains. “Different from conventional implants based on metal electrodes, graphene-based electrodes do not generate any electrical artifacts upon interacting with light used for imaging or optogenetics. That enables crosstalk free integration of three modalities: imaging, stimulation and recording to investigate brain activity over multiple spatial scales extending from single neurons to large populations of neurons in the same experiment.”

The team’s new fabrication process avoids any crack formation in the transfer process, resulting in a 95-100% yield for the electrode arrays. This fabrication quality is important for expanding this technology to high-density large area transparent arrays to monitor brain-scale cortical activity in large animal models or humans.

“Our technology is also well-suited for neurovascular and neurometabolic studies, providing a ‘gold standard’ neuronal correlate for optical measurements of vascular, hemodynamic, and metabolic activity,” Kuzum points out. “It will find application in multiple areas, advancing our understanding of how microscopic neural activity at the cellular scale translates into macroscopic activity of large neuron populations.”

“Combining optical techniques with electrical recordings using graphene electrodes will allow to connect the large body of neuroscience knowledge obtained from animal models to human studies mainly relying on electrophysiological recordings of brain-scale activity,” she adds.

Next steps for the team involve employing this technology to investigate coupling and information transfer between different brain regions.

This work is part of the US BRAIN (Brain Research through Advancing Innovative Neurotechnologies) initiative and there’s more than one team working with transparent graphene electrodes. John Hewitt in an Oct. 21, 2014 posting on ExtremeTech describes two other teams’ work (Note: Links have been removed),

The solution [to the problems with metal electrodes], now emerging from multiple labs throughout the universe is to build flexible, transparent electrode arrays from graphene. Two studies in the latest issue of Nature Communications, one from the University of Wisconsin-Madison and the other from Penn [University of Pennsylvania], describe how to build these devices.

The University of Wisconsin researchers are either a little bit smarter or just a little bit richer, because they published their work open access. It’s a no-brainer then that we will focus on their methods first, and also in more detail. To make the arrays, these guys first deposited the parylene (polymer) substrate on a silicon wafer, metalized it with gold, and then patterned it with an electron beam to create small contact pads. The magic was to then apply four stacked single-atom-thick graphene layers using a wet transfer technique. These layers were then protected with a silicon dioxide layer, another parylene layer, and finally molded into brain signal recording goodness with reactive ion etching.

PennTransparentelectrodeThe researchers went with four graphene layers because that provided optimal mechanical integrity and conductivity while maintaining sufficient transparency. They tested the device in opto-enhanced mice whose neurons expressed proteins that react to blue light. When they hit the neurons with a laser fired in through the implant, the protein channels opened and fired the cell beneath. The masterstroke that remained was then to successfully record the electrical signals from this firing, sit back, and wait for the Nobel prize office to call.

The Penn State group [Note: Every reearcher mentioned in the paper Hewitt linked to is from the University of Pennsylvania] in the  used a similar 16-spot electrode array (pictured above right), and proceeded — we presume — in much the same fashion. Their angle was to perform high-resolution optical imaging, in particular calcium imaging, right out through the transparent electrode arrays which simultaneously recorded in high-temporal-resolution signals. They did this in slices of the hippocampus where they could bring to bear the complex and multifarious hardware needed to perform confocal and two-photon microscopy. These latter techniques provide a boost in spatial resolution by zeroing in over narrow planes inside the specimen, and limiting the background by the requirement of two photons to generate an optical signal. We should mention that there are voltage sensitive dyes available, in addition to standard calcium dyes, which can almost record the fastest single spikes, but electrical recording still reigns supreme for speed.

What a mouse looks like with an optogenetics system plugged in

What a mouse looks like with an optogenetics system plugged in

One concern of both groups in making these kinds of simultaneous electro-optic measurements was the generation of light-induced artifacts in the electrical recordings. This potential complication, called the Becqueral photovoltaic effect, has been known to exist since it was first demonstrated back in 1839. When light hits a conventional metal electrode, a photoelectrochemical (or more simply, a photovoltaic) effect occurs. If present in these recordings, the different signals could be highly disambiguatable. The Penn researchers reported that they saw no significant artifact, while the Wisconsin researchers saw some small effects with their device. In particular, when compared with platinum electrodes put into the opposite side cortical hemisphere, the Wisconsin researchers found that the artifact from graphene was similar to that obtained from platinum electrodes.

Here’s a link to and a citation for the latest research from UCSD,

Deep 2-photon imaging and artifact-free optogenetics through transparent graphene microelectrode arrays by Martin Thunemann, Yichen Lu, Xin Liu, Kıvılcım Kılıç, Michèle Desjardins, Matthieu Vandenberghe, Sanaz Sadegh, Payam A. Saisan, Qun Cheng, Kimberly L. Weldy, Hongming Lyu, Srdjan Djurovic, Ole A. Andreassen, Anders M. Dale, Anna Devor, & Duygu Kuzum. Nature Communicationsvolume 9, Article number: 2035 (2018) doi:10.1038/s41467-018-04457-5 Published: 23 May 2018

This paper is open access.

You can find out more about the US BRAIN initiative here and if you’re curious, you can find out more about the project at UCSD here. Duygu Kuzum (now at UCSD) was at  the University of Pennsylvania in 2014 and participated in the work mentioned in Hewitt’s 2014 posting.

Creating cheap, small carbon nanotubes

The excitement fairly crackles off the video,

A May 24, 2018 news item on Nanowerk announces the research,

Imagine a box you plug into the wall that cleans your toxic air and pays you cash.

That’s essentially what Vanderbilt University researchers produced after discovering the blueprint for turning the carbon dioxide into carbon nanotubes with small diameters.

Carbon nanotubes are supermaterials that can be stronger than steel and more conductive than copper. The reason they’re not in every application from batteries to tires is that these amazing properties only show up in the tiniest nanotubes, which are extremely expensive. Not only did the Vanderbilt team show they can make these materials from carbon dioxide sucked from the air, but how to do this in a way that is much cheaper than any other method out there.

I’m not sure what ‘small’ means in this context. I’ve heard of long and short carbon nanotubes (CNTs) and also of single-walled, multi-walled, and double-walled CNTs. I wish there’d been an an explanation and measurements for ‘small diameter CNTs’. That nitpick aside, a May 23, 2018 Vanderbilt University news release by Heidi Hall adds a few more technical details,

These materials, which Assistant Professor of Mechanical Engineering Cary Pint calls “black gold,” could steer the conversation from the negative impact of emissions to how we can use them in future technology.

“One of the most exciting things about what we’ve done is use electrochemistry to pull apart carbon dioxide into elemental constituents of carbon and oxygen and stitch together, with nanometer precision, those carbon atoms into new forms of matter,” Pint said. “That opens the door to being able to generate really valuable products with carbon nanotubes.

“These could revolutionize the world.”

In a report published today in ACS [American Chemical Society] Applied Materials and Interfaces, Pint, interdisciplinary material science Ph.D. student Anna Douglas and their team describe how tiny nanoparticles 10,000 times smaller than a human hair can be produced from coatings on stainless steel surfaces. The key was making them small enough to be valuable.

“The cheapest carbon nanotubes on the market cost around $100-200 per kilogram,” Douglas said. “Our research advance demonstrates a pathway to synthesize carbon nanotubes better in quality than these materials with lower cost and using carbon dioxide captured from the air.”

But making small nanotubes is no small task. The research team showed that a process called Ostwald ripening — where the nanoparticles that grow the carbon nanotubes change in size to larger diameters — is a key contender against producing the infinitely more useful size. The team showed they could partially overcome this by tuning electrochemical parameters to minimize these pesky large nanoparticles.

side-by-side photos showing stainless steel plate becoming covered in carbon nanotubes (which look like lumps of ash or mud)
Small diameter carbon nanotubes grown on a stainless steel surface. (Pint Lab/Vanderbilt University)

This core technology led Pint and Douglas to co-found SkyNano LLC, a company focused on building upon the science of this process to scale up and commercialize products from these materials.

“What we’ve learned is the science that opens the door to now build some of the most valuable materials in our world, such as diamonds and single-walled carbon nanotubes, from carbon dioxide that we capture from air through our process,” Pint said.

Here’s a link to and a citation for the paper,

Toward Small-Diameter Carbon Nanotubes Synthesized from Captured Carbon Dioxide: Critical Role of Catalyst Coarsening by Anna Douglas, Rachel Carter, Mengya Li, and Cary L. Pint. ACS Appl. Mater. Interfaces, Article ASAP DOI: 10.1021/acsami.8b02834 Publication Date (Web): May 1, 2018

Copyright © 2018 American Chemical Society

This paper is behind a paywall.

Regarding the start-up, SkyNano, which Douglas and Pint have co-founded, it looks to be at a  very early stage.

Preserving art canvases (think Van Gogh, Picasso, Vermeer, and others) with nanomaterials

It has to be disconcerting to realize that your precious paintings are deteriorating day by day.  In a June 22, 2017 posting titled ‘Art masterpieces are turning into soap‘,

This piece of research has made a winding trek through the online science world. First it was featured in an April 20, 2017 American Chemical Society news release on EurekAlert,

A good art dealer can really clean up in today’s market, but not when some weird chemistry wreaks havoc on masterpieces [emphasis mine]. Art conservators started to notice microscopic pockmarks forming on the surfaces of treasured oil paintings that cause the images to look hazy. It turns out the marks are eruptions of paint caused, weirdly, by soap that forms via chemical reactions. Since you have no time to watch paint dry, we explain how paintings from Rembrandts to O’Keefes are threatened by their own compositions — and we don’t mean the imagery.

Here’s the video,


Now, for the latest: canavases are deteriorating too. A May 23, 2018 news item on Nanowerk announces the latest research on the ‘canvas issue’ (Note: A link has been removed),

Paintings by Vincent van Gogh, Pablo Picasso and Johannes Vermeer have been delighting art lovers for years. But it turns out that these works of art might be their own worst enemy — the canvases they were painted on can deteriorate over time.

In an effort to combat this aging process, one group is reporting in ACS Applied Nano Materials (“Combined Nanocellulose/Nanosilica Approach for Multiscale Consolidation of Painting Canvases”) that nanomaterials can provide multiple layers of reinforcement.

A May 23, 2018 American Chemical Society (ACS) news release (also on EurekAlert), which originated the news item,  expands on the theme,

One of the most important parts of a painting is the canvas, which is usually made from cellulose-based fibers. Over time, the canvas ages, resulting in discoloration, wrinkles, tears and moisture retention, all greatly affecting the artwork. To combat aging, painting conservators currently place a layer of adhesive and a lining on the back of a painting, but this treatment is invasive and difficult to reverse. In previous work, Romain Bordes and colleagues from Chalmers University of Technology, Sweden, investigated nanocellulose as a new way to strengthen painting canvases on their surfaces. In addition, together with Krzysztof Kolman, they showed that silica nanoparticles can strengthen individual paper and cotton fibers. So, they next wanted to combine these two methods to see if they could further strengthen aging canvas.

The team combined polyelectrolyte-treated silica nanoparticles (SNP) with cellulose nanofibrils (CNF) for a one-step treatment. The researchers first treated canvases with acid and oxidizing conditions to simulate aging. When they applied the SNP-CNF treatment, the SNP penetrated and strengthened the individual fibers of the canvas, making it stiffer compared to untreated materials. The CNF strengthened the surface of the canvas and increased the canvas’s flexibility. The team notes that this treatment could be a good alternative to conventional methods.

Here’s a link to and a citation for the paper,

Combined Nanocellulose/Nanosilica Approach for Multiscale Consolidation of Painting Canvases by Krzysztof Kolman, Oleksandr Nechyporchuk, Michael Persson, Krister Holmberg, and Romain Bordes. ACS Appl. Nano Mater., Article ASAP DOI: 10.1021/acsanm.8b00262 Publication Date (Web): April 26, 2018

Copyright © 2018 American Chemical Society

This image illustrating the researchers’ solution accompanies the article,

Courtesy: ACS

The European Union’s NanoRestART project was mentioned here before they’d put together this introductory video, which provides a good overview of the research,

For more details about the problems with contemporary and modern art, there’s my April 4, 2016 posting when the NanoRestART project was first mentioned here and there’s my Jan. 10, 2017 posting which details research into 3D-printed art and some of the questions raised by the use of 3D printing and other emerging technologies in the field of contemporary art.

ARPICO November 13, 2018 event in Vancouver (Canada): The Mysterious Dark-Side of the Universe: From Quarks to the Big Bang with Dark Matter

The Society of Italian Researchers and Professionals in Western Canada (ARPICO) is hosting a physics event for those of us who don’t have Phd’s in physics. From an October 24, 2018 ARPICO announcement (received via email),

The second event of ARPICO’s fall 2018 activity will take place on Tuesday, November 13th, 2018 at the Roundhouse Community Centre (Room B). Our speaker will be Dr. Pietro Giampa, a physicist who recently joined the ranks of the TRIUMF laboratories [Canada’s particle accelerator centre and, formerly, Canada’s National Laboratory for Particle and Nuclear Physics] here in Vancouver. Dr. Giampa will give us an intriguing and, importantly, layperson-intelligible overview on the state of our knowledge of the universe especially in regards to so-called dark matter, a chapter of physics that the most complete theoretical model to-date cannot explain. We will learn, among other things, about an ambitious experiment (set up in a Canadian mine!) [emphasis mine] to detect neutrinos, fundamental and very elusive particles of our  cosmos. You can read a summary of Pietro Giampa’s lecture as well as his short professional biography below.

We look forward to seeing everyone there.

The evening agenda is as follows:

  • 6:30 pm – Doors Open for Registration
  • 7:00 pm – Start of the evening event with introductions & lecture by Dr. Pietro Giampa
  • ~8:15 pm – Q & A Period
  • to follow – Mingling & Refreshments until about 9:30 pm

If you have not already done so, please register for the event by visiting the EventBrite link or RSVPing to info@arpico.ca.

Further details are also available at arpico.ca and Eventbrite.

More details from the email announcement,

The Mysterious Dark-Side of the Universe: From Quarks to the Big Bang with Dark Matter

Understanding the true nature of our universe is one of the most fundamental quests of our society. The path of knowledge acquisition in that quest has led us to the hypothesis of “dark matter”, that is, a large proportion of the mass of the universe which appears invisible. In this lecture, with minimal technical language we will journey through the structure and evolution of the universe, from subatomic particles to the big bang, which gave rise to our universe, in an ultimate research to describe the dark side of the universe called dark matter. We will review what we have learnt thus far about dark matter, and get an in-depth look at how scientists are searching for something that can not be seen.

Dr. Pietro Giampa originally completed his undergraduate in physics at Royal Holloway University of London in the UK, where he wrote a thesis on SuperSymmetry Searches with the ATLAS Detector (so LHC related). Following his undergraduate, he completed a Master Degree in particle physics at the same institute where he developed a novel technique for directional detection of neutrons. It was after his master that he moved to Canada to complete his Ph.D at Queen’s University in Particle Astrophysics, working on the DEAP-3600 Experiment with Nobel laureate Prof. Arthur McDonald. In the summer of 2017 he moved to TRIUMF, where he is currently the Otto Hausser Fellow. At TRIUMF he continues his research for new forms of physics, by studying Dark Matter and Ultra-Cold Neutrons.

 


WHEN: Tuesday, November 13th, 2018 at 7:00pm (doors open at 6:30pm)

WHERE: Roundhouse Community Centre, Room B – 181 Roundhouse Mews, Vancouver, BC, V6Z 2W3

RSVP: Please RSVP at EventBrite (https://mysteryofdarkmatter.eventbrite.ca/) or email info@arpico.ca


Tickets are Needed

  • Tickets are FREE, but all individuals are requested to obtain “free-admission” tickets on EventBrite site due to limited seating at the venue. Organizers need accurate registration numbers to manage wait lists and prepare name tags.
  • All ARPICO events are 100% staffed by volunteer organizers and helpers, however, room rental, stationery, and guest refreshments are costs incurred and underwritten by members of ARPICO. Therefore to be fair, all audience participants are asked to donate to the best of their ability at the door or via EventBrite to “help” defray costs of the event.

FAQs

  • Where can I contact the organizer with any questions? info@arpico.ca
  • Do I have to bring my printed ticket to the event? No, you do not. Your name will be on our Registration List at the Check-in Desk.
  • Is my registration/ticket transferrable? If you are unable to attend, another person may use your ticket. Please send us an email at info@arpico.ca of this substitution to correct our audience Registration List and to prepare guest name tags.
  • Can I update my registration information? Yes. If you have any questions, contact us at info@arpico.ca
  • I am having trouble using EventBrite and cannot reserve my ticket(s). Can someone at ARPICO help me with my ticket reservation? Of course, simply send your ticket request to us at info@arpico.ca so we help you.

What are my transport/parking options?

  • Bus/Train: The Canada Line Yaletown Skytrain station is a 1 minute walk from the Roundhouse Community Centre.
  • Parking: Pay Parking is underground at the community centre.  Access is available via Drake Street.

With regard to the Canadian mine and neutrino experiments, I hunted down a little more information (from an October 6, 2015 article by Kate Allen for thestar.com), Note: A link has been removed,

Canadian physicist Arthur B. McDonald has won the Nobel Prize for discoveries about the behaviour of a mysterious solar particle, teased from an experiment buried two kilometres below Sudbury [Ontario].

The Queen’s University professor emeritus was honoured for co-discovering that elusive particles known as neutrinos can change their identity — or “oscillate” — as they travel from the sun. It proved that neutrinos must have mass, a finding that upset the Standard Model of particle physics and opened new avenues for research into the fundamental properties of the universe.

McDonald, 72, shares the prize with Takaaki Kajita, whose Japanese collaboration made the same discovery with slightly different methods.

To measure solar neutrinos, McDonald and a 130-person international team built a massive detector in an operational copper mine southwest of Sudbury. …

To solve this problem, McDonald and his colleagues dreamt up SNO. Deep in an INCO mine (now owned by Vale), protected from cosmic radiation constantly bombarding the earth’s surface, the scientists installed a 12-metre-wide acrylic vessel filled with 1,000 tonnes of ultra-pure heavy water. The vessel was surrounded by a geodesic sphere equipped with 9,456 light sensors. The whole thing was sunk in a 34-metre-high cavity filled with regular water.

When neutrinos hit the heavy water, an event that occurred about 10 times a day, they emitted a flash of light, which researchers could analyze to measure the particles’ properties.

Allen’s article has more details for anyone who might want to read up on neutrinos. Regardless, I’m sure Dr.Giampa is fully prepared to guide the uninitiated into the mysteries of the universe as they pertain to dark matter, neutrinos, and ultra-cold neutrons.

2018 Canadian Science Policy Conference (Nov. 7 – 9, 2018) highlights and Council of Canadian Academies: a communications job, a report, and more

This is a going to a science policy heavy posting with both a conference and the latest report from the Canadian Council of Academies (CCA).

2018 Canadian Science Policy Conference

As I noted in my March 1, 2018 posting, this is the fourth year in a row that the conference is being held in Ottawa and the theme for this 10th edition is ‘Building Bridges Between Science, Policy and Society‘.

The dates are November 7 -9, 2018 and as the opening draws closer I’m getting more ‘breathlessly enthusiastic’ announcements. Here are a few highlights from an October 23, 2018 announcement received via email,

CSPC 2018 is honoured to announce that the Honourable Kirsty Duncan, Minister of Science and Sport, will be delivering the keynote speech of the Gala Dinner on Thursday, November 8 at 7:00 PM. Minister Duncan will also hand out the 4th Science Policy Award of Excellence to the winner of this year’s competition.

CSPC 2018 features 250 speakers, a record number, and above is the breakdown of the positions they hold, over 43% of them being at the executive level and 57% of our speakers being women.

*All information as of October 15, 2018

If you think that you will not meet any new people at CSPC and all of the registrants are the same as last year, think again!

Over 57% of  registrants are attending the conference for the FIRST TIME!

Secure your spot today!

*All information as of October 15, 2018

Here’s more from an October 31, 2018 announcement received via email,

One year after her appointment as Canada’s Chief Science Advisor, Dr. Mona Nemer will discuss her experience with the community. Don’t miss this opportunity.

[Canadian Science Policy Centre editorials in advance of conference]

Paul Dufour
“Evidence and Science in Parliament–Looking Back at CSPC and Moving Forward”

Dr. Tom Corr
“Commercializing Innovation in Canada: Advancing in the Right Direction”

Joseph S Sparling, PhD
“Reimagining the Canadian Postdoctoral Training System”

Milton Friesen
“Conspiring Together for Good: Institutional Science and Religion”

Joseph Tafese
“Science and the Next Generation : Science and Inclusivity, Going beyond the Slogans”

Eva Greyeyes
“Opinion Editorial for CSPC, November 2018”

Monique Crichlow
Chris Loken

“Policy Considerations Towards Converged HPC-AI Platforms”

Should you be in the Ottawa area November 7 – 9, 2018, it’s still possible to register.

**Update November 6, 2018: The 2018 CSPC is Sold Out!**

Council of Canadian Academies: job and the ‘managing innovation’ report

Let’s start with the job (from the posting),

October 17, 2018

Role Title:      Director of Communications
Deadline:       November 5, 2018
Salary:            $115,000 to $165,000

About the Council of Canadian Academies
The Council of Canadian Academies (CCA) is a not-for-profit organization that conducts assessments of evidence on scientific topics of public interest to inform decision-making in Canada.

Role Summary
The CCA is seeking an experienced communications professional to join its senior management team as Director of Communications. Reporting to the President and CEO, the Director is responsible for developing and implementing a communications plan for the organization that promotes and highlights the CCA’s work, brand, and overall mission to a variety of potential users and stakeholders; overseeing the publication and dissemination of high-quality hard copy and online products; and providing strategic advice to the President and CCA’s Board, Committees, and Panels. In fulfilling these responsibilities, the Director of Communications is expected to work with a variety of interested groups including the media, the broad policy community, government, and non-governmental organizations.

Key Responsibilities and Accountabilities
Under the direction of the President and CEO, the Director leads a small team of communications and publishing professionals to meet the responsibilities and accountabilities outlined below.

Strategy Development and External Communications
• Develop and execute an overall strategic communications plan for the organization that promotes and highlights the CCA’s work, brand, and overall mission.
• Oversee the CCA’s presence and influence on digital and social platforms including the development and execution of a comprehensive content strategy for linking CCA’s work with the broader science and policy ecosystem with a focus on promoting and disseminating the findings of the CCA’s expert panel reports.
• Provide support, as needed for relevant government relations activities including liaising with communications counterparts, preparing briefing materials, responding to requests to share CCA information, and coordinating any appearances before Parliamentary committees or other bodies.
• Harness opportunities for advancing the uptake and use of CCA assessments, including leveraging the strengths of key partners particularly the founding Academies.

Publication and Creative Services
• Oversee the creative services, quality control, and publication of all CCA’s expert panel reports including translation, layout, quality assurance, graphic design, proofreading, and printing processes.
• Oversee the creative development and publication of all CCA’s corporate materials including the Annual Report and Corporate Plan through content development, editing, layout, translation, graphic design, proofreading, and printing processes.

Advice and Issues Management
• Provide strategic advice and support to the President’s Office, Board of Directors, Committees, and CCA staff about increasing the overall impact of CCA expert panel reports, brand awareness, outreach opportunities, and effective science communication.
• Provide support to the President by anticipating project-based or organizational issues, understanding potential implications, and suggesting strategic management solutions.
• Ensure consistent messages, style, and approaches in the delivery of all internal and external communications across the organization.

Leadership
• Mentor, train, and advise up to five communications and publishing staff on a day-to-day basis and complete annual performance reviews and planning.
• Lead the development and implementation of all CCA-wide policy and procedures relating to all aspects of communications and publishing.
• Represent the issues, needs, and ongoing requirements for the communications and publishing staff as a member of the CCA senior management team.

Knowledge Requirements
The Director of Communications requires:
• Superior knowledge of communications and public relations principles – preferably as it applies in a non-profit or academic setting;
• Extensive experience in communications planning and issues management;
• Knowledge of current research, editorial, and publication production standards and procedures including but not limited to: translation, copy-editing, layout/design, proofreading and publishing;
• Knowledge of evaluating impact of reports and assessments;
• Knowledge in developing content strategy, knowledge mobilization techniques, and creative services and design;
• Knowledge of human resource management techniques and experience managing a team;
• Experience in coordinating, organizing and implementing communications activities including those involving sensitive topics;
• Knowledge of the relationships and major players in Canada’s intramural and extramural science and public policy ecosystem, including awareness of federal science departments and Parliamentary committees, funding bodies, and related research groups;
• Knowledge of Microsoft Office Suite, Adobe Creative Suite, WordPress and other related programs;
• Knowledge of a variety of social media platforms and measurement tools.

Skills Requirements
The Director of Communications must have:
• Superior time and project management skills
• Superior writing skills
• Superior ability to think strategically regarding how best to raise the CCA’s profile and ensure impact of the CCA’s expert panel reports
• Ability to be flexible and adaptable; able to respond quickly to unanticipated demands
• Strong advisory, negotiation, and problem-solving skills
• Strong skills in risk mitigation
• Superior ability to communicate in both written and oral forms, effectively and diplomatically
• Ability to mentor, train, and provide constructive feedback to direct reports

Education and Experience
This knowledge and skillset is typically obtained through the completion of a post-secondary degree in Journalism, Communications, Public Affairs or a related field, and/or a minimum of 10
years of progressive and related experience. Experience in an organization that has addressed topics in public policy would be valuable.

Language Requirements: This position is English Essential. Fluency in French is a strong asset.

To apply to this position please send your CV and cover letter to careers@scienceadvice.ca before November 5, 2018. The cover letter should answer the following questions in 1,000 words or less:

1. How does your background and work experience make you well-suited for the position of Director of Communications at CCA?
2. What trends do you see emerging in the communications field generally, and in science and policy communications more specifically? How might CCA take advantage of these trends and developments?
3. Knowing that CCA is in the business of conducting assessments of evidence on important policy topics, how do you feel communicating this type of science differs from communicating other types of information and knowledge?

Improving Innovation Through Better Management

The Council of Canadian Academies released their ‘Improving Innovation Through Better Management‘ report on October 18, 2018..As some of my regular readers (assuming there are some) might have predicted, I have issues.

There’s a distinct disconnection between the described problem and the questions to be answered. From the ‘Improving Innovation Through Better Management‘ summary webpage,

While research is world-class and technology start-ups are thriving, few companies grow and mature in Canada. This cycle — invent and sell, invent and sell — allows other countries to capture much of the economic and social benefits of Canadian-invented products, processes, marketing methods, and business models. …

So, the problem is ‘invent and sell’. Leaving aside the questionable conclusion that other countries are reaping the benefits of Canadian innovation (I’ll get back to that shortly), what questions could you ask about how to break the ‘invent and sell, invent and sell’ cycle? Hmm, maybe we should ask, How do we break the ‘invent and sell’ cycle in Canada?

The government presented two questions to deal with the problem and no, how to break the cycle is not one of the questions. From the ‘Improving Innovation Through Better Management‘ summary webpage,

… Escaping this cycle may be aided through education and training of innovation managers who can systematically manage ideas for commercial success and motivate others to reimagine innovation in Canada.

To understand how to better support innovation management in Canada, Innovation, Science and Economic Development Canada (ISED) asked the CCA two critical questions: What are the key skills required to manage innovation? And, what are the leading practices for teaching these skills in business schools, other academic departments, colleges/polytechnics, and industry?

As lawyers, journalists, scientists, doctors, librarians, and anyone who’s ever received misinformation can tell you, asking the right questions can make a big difference.

As for the conclusion that other countries are reaping the benefits of Canadian innovation, is there any supporting data? We enjoy a very high standard of living and have done so for at least a couple of generations. The Organization for Economic Cooperation and Development (OECD) has a Better Life Index, which ranks well-being on these 11 dimensions (from the OECD Better Life Index entry on Wikipedia), Note: Links have been removed,

  1. Housing: housing conditions and spendings (e.g. real estate pricing)
  2. Income: household income and financial wealth
  3. Jobs: earnings, job security and unemployment
  4. Community: quality of social support network
  5. Education: education and what you get out of it
  6. Environment: quality of environment (e.g. environmental health)
  7. Governance: involvement in democracy
  8. Health
  9. Life Satisfaction: level of happiness
  10. Safety: murder and assault rates
  11. Work-life balance

In 2017, the index ranked Canada as fifth in the world while the US appears to have slipped from a previous ranking of 7th to 8th. (See these Wikipedia entries with relevant subsections for rankings:  OECD Better Life Index; Rankings, 2017 ranking and Standard of living in the United States, Measures, 3rd paragraph.)

This notion that other countries are profiting from Canadian innovation while we lag behind has been repeated so often that it’s become an article of faith and I never questioned it until someone else challenged me. This article of faith is repeated internationally and sometimes seems that every country in the world is worried that someone else will benefit from their national innovation.

Getting back to the Canadian situation, we’ve decided to approach the problem by not asking questions about our article of faith or how to break the ‘invent and sell’ cycle. Instead of questioning an assumption and producing an open-ended question, we have these questions (1) What are the key skills required to manage innovation? (2) And, what are the leading practices for teaching these skills in business schools, other academic departments, colleges/polytechnics, and industry?

in my world that first question, would be a second tier question, at best. The second question, presupposes the answer: more training in universities and colleges. I took a look at the report’s Expert Panel webpage and found it populated by five individuals who are either academics or have strong ties to academe. They did have a workshop and the list of participants does include people who run businesses, from the Improving Innovation Through Better Management‘ report (Note: Formatting has not been preserved),

Workshop Participants

Max Blouw,
Former President and Vice-Chancellor of
Wilfrid Laurier University (Waterloo, ON)

Richard Boudreault, FCAE,
Chairman, Sigma Energy
Storage (Montréal, QC)

Judy Fairburn, FCAE,
Past Board Chair, Alberta Innovates;
retired EVP Business Innovation & Chief Digital Officer,
Cenovus Energy Inc. (Calgary, AB)

Tom Jenkins, O.C., FCAE,
Chair of the Board, OpenText
(Waterloo, ON)

Sarah Kaplan,
Director of the Institute for Gender and the
Economy and Distinguished Professor, Rotman School of
Management, University of Toronto (Toronto, ON)

Jean-Michel Lemieux,
Senior Vice President of Engineering,
Shopify Inc. (Ottawa, ON)

Elicia Maine,
Academic Director and Professor, i2I, Beedie
School of Business, Simon Fraser University (Vancouver, BC)

Kathy Malas,
Innovation Platform Manager, CHU
Sainte Justine (Montréal, QC)

John L. Mann, FCAE,
Owner, Mann Consulting
(Blenheim, ON)

Jesse Rodgers,
CEO, Volta Labs (Halifax, NS)

Creso Sá,
Professor of Higher Education and Director of
the Centre for the Study of Canadian and International
Higher Education, Ontario Institute for Studies in Education,
University of Toronto (Toronto, ON)

Dhirendra Shukla,
Professor and Chair, J. Herbert Smith
Centre for Technology Management & Entrepreneurship,
Faculty of Engineering, University of New Brunswick
(Fredericton, NB)

Dan Sinai,
Senior Executive, Innovation, IBM Canada
(Toronto, ON)

Valerie Walker,
Executive Director, Business/Higher
Education Roundtable (Ottawa, ON)

J. Mark Weber,
Eyton Director, Conrad School of
Entrepreneurship & Business, University of Waterloo
(Waterloo, ON)

I am a little puzzled by the IBM executive’s presence (Dan Sinai) on this list. Wouldn’t Canadians holding onto their companies be counterproductive to IBM’s interests? As for John L. Mann, I’ve not been able to find him or his consulting company online. it’s unusual not to find any trace of an individual or company online these days.

In all there were nine individuals representing academic or government institutions in this list. The gender balance is 10 males and five females for the workshop participants and three males and two females for the expert panel. There is no representation from the North or from Manitoba, Saskatchewan, Prince Edward Island, or Newfoundland.

If they’re serious about looking at how to use innovation to drive higher standards of living, why aren’t there any people from Asian countries where they have been succeeding at that very project? South Korea and China come to mind.

I’m sure there are some excellent ideas in the report, I just wish they’d taken their topic to heart and actually tried to approach innovation in Canada in an innovative fashion.

Meanwhile, Vancouver gets another technology hub, from an October 30, 2018 article by Kenneth Chan for the Daily Hive (Vancouver [Canada]), Note: Links have been removed,

Vancouver’s rapidly growing virtual reality (VR) and augmented reality (AR) tech sectors will greatly benefit from a new VR and AR hub created by Launch Academy.

The technology incubator has opened a VR and AR hub at its existing office at 300-128 West Hastings Street in downtown, in partnership with VR/AR Association Vancouver. Immersive tech companies have access to desk space, mentorship programs, VR/AR equipment rentals, investor relations connected to Silicon Valley [emphasis mine], advisory services, and community events and workshops.

Within the Vancouver tech industry, the immersive sector has grown from 15 companies working in VR and AR in 2015 to 220 organizations today.

Globally, the VR and AR market is expected to hit a value of $108 billion by 2021, with tech giants like Amazon, Apple, Facebook, Google, and Microsoft [emphasis mine] investing billions into product development.

In the Vancouver region, the ‘invent and sell’ cycle can be traced back to the 19th century.

One more thing, as I was writing this piece I tripped across this news: “$7.7-billion pact makes Encana more American than Canadian‘ by Geoffrey Morgan. It’s in the Nov. 2, 2018 print edition of the Vancouver Sun’s front page for business. “Encana Corp., the storied Canadian company that had been slowly transitioning away from Canada and natural gas over the past few years under CEO [Chief Executive Officer] Doug Suttles, has pivoted aggressively to US shale basins. … Suttles, formerly as BP Plc. executive, moved from Calgary [Alberta, Canada] to Denver [Colorado, US], though the company said that was for personal reasons and not a precursor to relocation of Encana’s headquarters.”  Yes, that’s quite believable. By the way, Suttles has spent* most of his life in the US (Wikipedia entry).

In any event, it’s not just Canadian emerging technology companies that get sold or somehow shifted out of Canada.

So, should we break the cycle and, if so, how are we going to do it?

*’spend’ corrected to ‘spent’ on November 6, 2018.

Injectable bandages for internal bleeding and hydrogel for the brain

This injectable bandage could be a gamechanger (as they say) if it can be taken beyond the ‘in vitro’ (i.e., petri dish) testing stage. A May 22, 2018 news item on Nanowerk makes the announcement (Note: A link has been removed),

While several products are available to quickly seal surface wounds, rapidly stopping fatal internal bleeding has proven more difficult. Now researchers from the Department of Biomedical Engineering at Texas A&M University are developing an injectable hydrogel bandage that could save lives in emergencies such as penetrating shrapnel wounds on the battlefield (Acta Biomaterialia, “Nanoengineered injectable hydrogels for wound healing application”).

A May 22, 2018 US National Institute of Biomedical Engineering and Bioengiineering news release, which originated the news item, provides more detail (Note: Links have been removed),

The researchers combined a hydrogel base (a water-swollen polymer) and nanoparticles that interact with the body’s natural blood-clotting mechanism. “The hydrogel expands to rapidly fill puncture wounds and stop blood loss,” explained Akhilesh Gaharwar, Ph.D., assistant professor and senior investigator on the work. “The surface of the nanoparticles attracts blood platelets that become activated and start the natural clotting cascade of the body.”

Enhanced clotting when the nanoparticles were added to the hydrogel was confirmed by standard laboratory blood clotting tests. Clotting time was reduced from eight minutes to six minutes when the hydrogel was introduced into the mixture. When nanoparticles were added, clotting time was significantly reduced, to less than three minutes.

In addition to the rapid clotting mechanism of the hydrogel composite, the engineers took advantage of special properties of the nanoparticle component. They found they could use the electric charge of the nanoparticles to add growth factors that efficiently adhered to the particles. “Stopping fatal bleeding rapidly was the goal of our work,” said Gaharwar. “However, we found that we could attach growth factors to the nanoparticles. This was an added bonus because the growth factors act to begin the body’s natural wound healing process—the next step needed after bleeding has stopped.”

The researchers were able to attach vascular endothelial growth factor (VEGF) to the nanoparticles. They tested the hydrogel/nanoparticle/VEGF combination in a cell culture test that mimics the wound healing process. The test uses a petri dish with a layer of endothelial cells on the surface that create a solid skin-like sheet. The sheet is then scratched down the center creating a rip or hole in the sheet that resembles a wound.

When the hydrogel containing VEGF bound to the nanoparticles was added to the damaged endothelial cell wound, the cells were induced to grow back and fill-in the scratched region—essentially mimicking the healing of a wound.

“Our laboratory experiments have verified the effectiveness of the hydrogel for initiating both blood clotting and wound healing,” said Gaharwar. “We are anxious to begin tests in animals with the hope of testing and eventual use in humans where we believe our formulation has great potential to have a significant impact on saving lives in critical situations.”

The work was funded by grant EB023454 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), and the National Science Foundation. The results were reported in the February issue of the journal Acta Biomaterialia.

The paper was published back in April 2018 and there was an April 2, 2018 Texas A&M University news release on EurekAlert making the announcement (and providing a few unique details),

A penetrating injury from shrapnel is a serious obstacle in overcoming battlefield wounds that can ultimately lead to death.Given the high mortality rates due to hemorrhaging, there is an unmet need to quickly self-administer materials that prevent fatality due to excessive blood loss.

With a gelling agent commonly used in preparing pastries, researchers from the Inspired Nanomaterials and Tissue Engineering Laboratory have successfully fabricated an injectable bandage to stop bleeding and promote wound healing.

In a recent article “Nanoengineered Injectable Hydrogels for Wound Healing Application” published in Acta Biomaterialia, Dr. Akhilesh K. Gaharwar, assistant professor in the Department of Biomedical Engineering at Texas A&M University, uses kappa-carrageenan and nanosilicates to form injectable hydrogels to promote hemostasis (the process to stop bleeding) and facilitate wound healing via a controlled release of therapeutics.

“Injectable hydrogels are promising materials for achieving hemostasis in case of internal injuries and bleeding, as these biomaterials can be introduced into a wound site using minimally invasive approaches,” said Gaharwar. “An ideal injectable bandage should solidify after injection in the wound area and promote a natural clotting cascade. In addition, the injectable bandage should initiate wound healing response after achieving hemostasis.”

The study uses a commonly used thickening agent known as kappa-carrageenan, obtained from seaweed, to design injectable hydrogels. Hydrogels are a 3-D water swollen polymer network, similar to Jell-O, simulating the structure of human tissues.

When kappa-carrageenan is mixed with clay-based nanoparticles, injectable gelatin is obtained. The charged characteristics of clay-based nanoparticles provide hemostatic ability to the hydrogels. Specifically, plasma protein and platelets form blood adsorption on the gel surface and trigger a blood clotting cascade.

“Interestingly, we also found that these injectable bandages can show a prolonged release of therapeutics that can be used to heal the wound” said Giriraj Lokhande, a graduate student in Gaharwar’s lab and first author of the paper. “The negative surface charge of nanoparticles enabled electrostatic interactions with therapeutics thus resulting in the slow release of therapeutics.”

Nanoparticles that promote blood clotting and wound healing (red discs), attached to the wound-filling hydrogel component (black) form a nanocomposite hydrogel. The gel is designed to be self-administered to stop bleeding and begin wound-healing in emergency situations. Credit: Lokhande, et al. 1

Here’s a link to and a citation for the paper,

Nanoengineered injectable hydrogels for wound healing application by Giriraj Lokhande, James K. Carrow, Teena Thakur, Janet R. Xavier, Madasamy Parani, Kayla J. Bayless, Akhilesh K. Gaharwar. Acta Biomaterialia Volume 70, 1 April 2018, Pages 35-47
https://doi.org/10.1016/j.actbio.2018.01.045

This paper is behind a paywall.

Hydrogel and the brain

It’s been an interesting week for hydrogels. On May 21, 2018 there was a news item on ScienceDaily about a bioengineered hydrogel which stimulated brain tissue growth after a stroke (mouse model),

In a first-of-its-kind finding, a new stroke-healing gel helped regrow neurons and blood vessels in mice with stroke-damaged brains, UCLA researchers report in the May 21 issue of Nature Materials.

“We tested this in laboratory mice to determine if it would repair the brain in a model of stroke, and lead to recovery,” said Dr. S. Thomas Carmichael, Professor and Chair of neurology at UCLA. “This study indicated that new brain tissue can be regenerated in what was previously just an inactive brain scar after stroke.”

The brain has a limited capacity for recovery after stroke and other diseases. Unlike some other organs in the body, such as the liver or skin, the brain does not regenerate new connections, blood vessels or new tissue structures. Tissue that dies in the brain from stroke is absorbed, leaving a cavity, devoid of blood vessels, neurons or axons, the thin nerve fibers that project from neurons.

After 16 weeks, stroke cavities in mice contained regenerated brain tissue, including new neural networks — a result that had not been seen before. The mice with new neurons showed improved motor behavior, though the exact mechanism wasn’t clear.

Remarkable stuff.