Tag Archives: ageing

Ageing population could drive progress in nanotechnology and robotics

A couple of theoreticians are proposing a generational gap as being a key source of conflict and technological process in the near future. From a July 27, 2016 news item on Nanotechnology Now,

The UN estimates that the number of people aged 65 and older will have reached almost a billion by 2030. The proportion of those aged over 80 will grow at particularly high rates, and their numbers are expected to reach 200 million by 2030 and triple that forty years later.

Due to a combination of an ageing population and declining birthrates, the demographic structure of most countries will change towards lower proportions of children and young people. As a result, the global division will no longer be between first- and third-world nations [also called developed and developing nations], but between old and young ones.

A July 25, 2016 National Research University Higher School of Economics [Russia] press release (also on EurekAlert), which originated the news item, expands on the theme,

According to the report of Senior Research Fellow of the HSE [Higher School of Economics] Laboratory for Monitoring the Risks of Socio-Political Destabilization Leonid Grinin and Senior Research Fellow of the International Centre for Education, Social and Humanitarian Studies Anton Grinin “Global Population Ageing and the Threat of Political Risks in the Light of Radical Technological Innovation in the Coming Decades.”, an increase in the number of older people will:

  • encourage societies facing workforce shortages to seek solutions to improve older people’s employability by helping them stay healthy, fit and full of energy for much longer than today;
  • encourage societies to focus more on rehabilitation of people with disabilities and provide them with new technology to support their employment;
  • encourage the development of labour-saving technologies, such as robotics, to assist caregivers;
  • lead to breakthroughs in medicine. Indeed, medical services will be the first to enter a new phase of technological revolution, radically changing the structure of production and people’s lives. Such a breakthrough will be associated what the authors call MANBRIC, i.e. a technological paradigm based on medicine, additive, nano- and bio- technologies, robotic, IT, and cognitive technologies;
  • boost government spending on healthcare, which today accounts for at least 10% of global GDP and can vary vastly across countries, e.g. reaching 17% in the U.S.;
  • promote the development of peripheral countries through higher spending on health care, leading to the emergence of a middle class, poverty reduction, literacy, and a better quality of life;
  • increase the demand for innovation and its financing from accumulated funds such as pensions and public allocations to medical and social needs;
  • lead to higher investment in supporting the health of ageing populations and the growing middle class.

Longevity Comes at a Cost

A confrontation between generations in the labor market and the weakening of democracy are the key risks associated with longer life expectancy.

Longer life spans and a lower proportion of young people in society may lead to the predominance of ‘third age’ voters. Politicians will need to tailor their messages to older and perhaps more conservative electorates. According to the researchers, “democracy can transform into a form of gerontocracy which may be hard to overcome; under such circumstances, competition for voters may lead to a crisis of democratic governance.”

A conflict between generations is another potential risk. As the retirement age increases, older employees will stay in the workforce longer – a situation which may hinder younger people’s careers and slow down technological progress.

A tendency towards gerontocracy has been particularly noticeable in Western Europe and the U.S., where democratic traditions are the strongest, but ethnic and cultural imbalances are increasingly visible. As a result, the U.S. may face confrontation between its younger Latinos and older white populations, and Europe may experience tensions between older white Christians and younger Muslims. Hence, globalization will inevitably cause such conflicts to transcend national borders and become global challenges.

I was not able to find the report mentioned in this release but I certainly would have liked to have looked at it. This redraws the conflict map in some interesting ways.

Breakthrough (science in six episodes on the National Geographic Channel)

US producing partners (television and movies), Ron Howard and Brian Grazer have decided to make science sexy according to the headline for an Oct. 30, 2015 article by Reid Nakamura for The Wrap. Reading the article which has no mention of sexiness reveals the producing partners had something else in mind,

In the era of “too much TV,” Grazer argues that people taking risks is what will help the industry survive. “People just have to make quality programs,” he said in an interview with TheWrap. “Taking chances usually will produce some trend creation that is really valuable to our business.”

Howard added that because “Breakthrough” has the potential to stand out.

“In reality, I don’t really agree that there’s too much, but there’s never enough good stuff that really does break through,” he said. “And it’s getting harder and harder to get fresh ideas, but I think that in all honesty, something like Brian and I coming in and doing this kind of science series offers that potential. Because it’s a different mindset creating this kind of content.”

To date, four episodes have been broadcast (from the Breakthrough episode page on the Internet Movie DataBase [IMDB]),

Fighting Pandemics

Viral outbreaks can become deadly pandemics in a matter of days. To prevent catastrophe, courageous scientists are fighting back with new treatments and vaccines.

More Than Human

Advances in science are fusing biology and technology to make us better, stronger, faster, and smarter; manipulating our genetic code; building exoskeletons that give us super strength; giving hope to people with traumatic spine injuries.

Decoding the Brain

After millennia of speculation about what goes on inside the human brain, we now have the tools to explore its hidden reaches. These tools are leading to research that may help those suffering from afflictions such as epilepsy and Alzheimer’s disease. They are also shedding light on the mystery of consciousness and what makes us who we are.

In recent years, close study of the aging process has opened up new ways that could help us all live healthier for longer. Can we move beyond treating individual diseases, and instead treat the aging process itself? But would a longer life necessarily be a better life? A loose-knit group of researchers believe the real breakthrough is extending our health span – the period of life spent free of disease.

Energy on the Edge

Not yet broadcast

Water Apocalypse

Not yet broadcast

Strangely there is no science advisor listed as part of the crew for these programmes and, even more strangely, the researcher for the series, A. Christine Maxfield, is a travel writer and tv host who seems not to have any science background or previous experience with science programmes.

Once an episode has been broadcast it is possible to view it online afterwards but you do need to be a subscriber. The first three episodes can be found here.

Some of the promotional material seems a bit odd to me. For example, there’s this in the material promoting The Age of Aging episode (broadcast Nov. 29, 2015) directed by Ron Howard and in which he also appears,

… Ron Howard explores the latest scientific studies trying to answer one question. Can aging be cured?

I find the thinking fundamentally disturbing. Aging is not a disease; it’s a process or a series of processes leading to death. If it’s thought of as a disease, then there’s an implication that it can be cured. However, I have no objection to aging as well as possible. On that note, there’s some rather interesting research coming out of Switzerland, from a Dec. 1, 2015 ETZ Zurich press release on EurekAlert,

Researchers at ETH Zurich and the JenAge consortium from Jena have now systematically gone through the genomes of three different organisms in search of the genes associated with the ageing process that are present in all three species – and thus derived from the genes of a common ancestor. Although they are found in different organisms, these so-called orthologous genes are closely related to each other, and they are all found in humans, too.

In order to detect these genes, the researchers examined around 40,000 genes in the nematode C. elegans, zebra fish and mice. By screening them, the scientists wanted to determine which genes are regulated in an identical manner in all three organisms in each comparable ageing stage – young, mature and old; i.e. either are they upregulated or downregulated during ageing.

As a measure of gene activity, the researchers measured the amount of messenger RNA (mRNA) molecules found in the cells of these animals. mRNA is the transcript of a gene and the blueprint of a protein. When there are many copies of an mRNA of a specific gene, it is very active; the gene is upregulated. Fewer mRNA copies, to the contrary, are regarded as a sign of low activity, explains Professor Michael Ristow, coordinating author of the recently published study and Professor of Energy Metabolism at ETH Zurich.

Out of this volume of information, the researchers used statistical models to establish an intersection of genes that were regulated in the same manner in the worms, fish and mice. This showed that the three organisms have only 30 genes in common that significantly influence the ageing process.

Reduce gene activity, live longer

By conducting experiments in which the mRNA of the corresponding genes were selectively blocked, the researchers pinpointed their effect on the ageing process in nematodes. With a dozen of these genes, blocking them extended the lifespan by at least five percent.

One of these genes proved to be particularly influential: the bcat-1 gene. “When we blocked the effect of this gene, it significantly extended the mean lifespan of the nematode by up to 25 percent,” says Ristow.

The researchers were also able to explain how this gene works: the bcat-1 gene carries the code for the enzyme of the same name, which degrades so-called branched-chain amino acids. Naturally occurring in food protein building blocks, these include the amino acids L-leucine, L-isoleucine and L-valine.

When the researchers inhibited the gene activity of bcat-1, the branched-chain amino acids accumulated in the tissue, triggering a molecular signalling cascade that increased longevity in the nematodes. Moreover, the timespan during which the worms remained healthy was extended. As a measure of vitality, the researchers measured the accumulation of ageing pigments, the speed at which the creatures moved, and how often the nematodes successfully reproduced. All of these parameters improved when the scientists inhibited the activity of the bcat-1 gene.

The scientists also achieved a life-extending effect when they mixed the three branched-chain amino acids into the nematodes’ food. However, the effect was generally less pronounced because the bcat-1 gene was still active, which meant that the amino acids continued to be degraded and their life-extending effects could not develop as effectively.

Conserved mechanism

Ristow has no doubt that the same mechanism occurs in humans. “We looked only for the genes that are conserved in evolution and therefore exist in all organisms, including humans,” he says.

In the present study, he and his Jena colleagues from the Leibniz Institute on Aging, the Leibniz Institute for Natural Product Research and Infection Biology, the Jena University Hospital and the Friedrich Schiller University purposefully opted not to study the impact on humans. But a follow-up study is already being planned. “However we cannot measure the life expectancy of humans for obvious reasons,” says the ETH professor. Instead, the researchers plan to incorporate various health parameters such as cholesterol or blood sugar levels in their study to obtain indicators on the health status of their subjects.

Health costs could be massively reduced

Ristow says that the multiple branched-chain amino acids are already being used to treat liver damage and are also added to sport nutrition products. “However, the point is not for people to grow even older, but rather to stay healthy for longer,” [emphasis mine] says the internist. The study will deliver important indicators on how the ageing process could be influenced and how age-related diseases such as diabetes or high blood pressure could be prevented. In light of unfavourable demographics and steadily increasing life expectancy, it is important to extend the healthy life phase and not to reach an even higher age that is characterised by chronic diseases, argue the researchers. With such preventive measures, an elderly person could greatly improve their quality of life while at the same time cutting their healthcare costs by more than half.

” … the point is not for people to grow even older, but rather to stay healthy for longer, ” I couldn’t agree more. Good luck with the gene work.

Finally, the next episode of Breakthrough, Energy on the Edge, is due to be broadcast in the US on Sunday, Dec. 6, 2015 on the National Geographic Channel.

Commercializing nanotechnology: Peter Thiel’s Breakout Labs and Argonne National Laboratories

Breakout Labs

I last wrote about entrepreneur Peter Thiel’s Breakout Labs project in an Oct. 26, 2011 posting announcing its inception. An Oct. 6, 2015 Breakout Labs news release (received in my email) highlights a funding announcement for four startups of which at least three are nanotechnology-enabled,

Breakout Labs, a program of Peter Thiel’s philanthropic organization, the Thiel Foundation, announced today that four new companies advancing scientific discoveries in biomedical, chemical engineering, and nanotechnology have been selected for funding.

“We’re always hearing about bold new scientific research that promises to transform the world, but far too often the latest discoveries are left withering in a lab,” said Lindy Fishburne, Executive Director of Breakout Labs. “Our mission is to help a new type of scientist-entrepreneur navigate the startup ecosystem and build lasting companies that can make audacious scientific discoveries meaningful to everyday life. The four new companies joining the Breakout Labs portfolio – nanoGriptech, Maxterial, C2Sense, and CyteGen – embody that spirit and we’re excited to be working with them to help make their vision a reality.”

The future of adhesives: inspired by geckos

Inspired by the gecko’s ability to scuttle up walls and across ceilings due to their millions of micro/nano foot-hairs,nanoGriptech (http://nanogriptech.com/), based in Pittsburgh, Pa., is developing a new kind of microfiber adhesive material that is strong, lightweight, and reusable without requiring glues or producing harmful residues. Currently being tested by the U.S. military, NASA, and top global brands, nanoGriptech’s flagship product Setex™ is the first adhesive product of its kind that is not only strong and durable, but can also be manufactured at low cost, and at scale.

“We envision a future filled with no-leak biohazard enclosures, ergonomic and inexpensive car seats, extremely durable aerospace adhesives, comfortable prosthetic liners, high performance athletic wear, and widely available nanotechnology-enabled products manufactured less expensively — all thanks to the grippy little gecko,” said Roi Ben-Itzhak, CFO and VP of Business Development for nanoGriptech.

A sense of smell for the digital world

Despite the U.S. Department of Agriculture’s recent goals to drastically reduce food waste, most consumers don’t realize the global problem created by 1.3 billion metric tons of food wasted each year — clogging landfills and releasing unsustainable levels of methane gas into the atmosphere. Using technology developed at MIT’s Swager lab, Cambridge, Ma.-based C2Sense(http://www.c2sense.com/) is developing inexpensive, lightweight hand-held sensors based on carbon nanotubes which can detect fruit ripeness and meat, fish and poultry freshness. Smaller than a half of a business card, these sensors can be developed at very low cost, require very little power to operate, and can be easily integrated into most agricultural supply chains, including food storage packaging, to ensure that food is picked, stored, shipped, and sold at optimal freshness.

“Our mission is to bring a sense of smell to the digital world. With our technology, that package of steaks in your refrigerator will tell you when it’s about to go bad, recommend some recipe options and help build out your shopping list,” said Jan Schnorr, Chief Technology Officer of C2Sense.

Amazing metals that completely repel water

MaxterialTM, Inc. develops amazing materials that resist a variety of detrimental environmental effects through technology that emulates similar strategies found in nature, such as the self-cleaning lotus leaf and antifouling properties of crabs. By modifying the surface shape or texture of a metal, through a method that is very affordable and easy to introduce into the existing manufacturing process, Maxterial introduces a microlayer of air pockets that reduce contact surface area. The underlying material can be chemically the same as ever, retaining inherent properties like thermal and electrical conductivity. But through Maxterial’s technology, the metallic surface also becomes inherently water repellant. This property introduces the superhydrophobic maxterial as a potential solution to a myriad of problems, such as corrosion, biofouling, and ice formation. Maxterial is currently focused on developing durable hygienic and eco-friendly anti-corrosion coatings for metallic surfaces.

“Our process has the potential to create metallic objects that retain their amazing properties for the lifetime of the object – this isn’t an aftermarket coating that can wear or chip off,” said Mehdi Kargar, Co-founder and CEO of Maxterial, Inc. “We are working towards a day when shipping equipment can withstand harsh arctic environments, offshore structures can resist corrosion, and electronics can be fully submersible and continue working as good as new.”

New approaches to combat aging

CyteGen (http://cytegen.com/) wants to dramatically increase the human healthspan, tackle neurodegenerative diseases, and reverse age-related decline. What makes this possible now is new discovery tools backed by the dream team of interdisciplinary experts the company has assembled. CyteGen’s approach is unusually collaborative, tapping into the resources and expertise of world-renowned researchers across eight major universities to focus different strengths and perspectives to achieve the company’s goals. By approaching aging from a holistic, systematic point of view, rather than focusing solely on discrete definitions of disease, they have developed a new way to think about aging, and to develop treatments that can help people live longer, healthier lives.

“There is an assumption that aging necessarily brings the kind of physical and mental decline that results in Parkinson’s, Alzheimer’s, and other diseases. Evidence indicates otherwise, which is what spurred us to launch CyteGen,” said George Ugras, Co-Founder and President of CyteGen.

To date, Breakout Labs has invested in more than two dozen companies at the forefront of science, helping radical technologies get beyond common hurdles faced by early stage companies, and advance research and development to market much more quickly. Portfolio companies have raised more than six times the amount of capital invested in the program by the Thiel Foundation, and represent six Series A valuations ranging from $10 million to $60 million as well as one acquisition.

You can see the original Oct. 6, 2015 Breakout Labs news release here or in this Oct. 7, 2015 news item on Azonano.

Argonne National Labs and Nano Design Works (NDW) and the Argonne Collaborative Center for Energy Storage Science (ACCESS)

The US Department of Energy’s Argonne National Laboratory’s Oct. 6, 2015 press release by Greg Cunningham announced two initiatives meant to speed commercialization of nanotechnology-enabled products for the energy storage and other sectors,

Few technologies hold more potential to positively transform our society than energy storage and nanotechnology. Advances in energy storage research will revolutionize the way the world generates and stores energy, democratizing the delivery of electricity. Grid-level storage can help reduce carbon emissions through the increased adoption of renewable energy and use of electric vehicles while helping bring electricity to developing parts of the world. Nanotechnology has already transformed the electronics industry and is bringing a new set of powerful tools and materials to developers who are changing everything from the way energy is generated, stored and transported to how medicines are delivered and the way chemicals are produced through novel catalytic nanomaterials.

Recognizing the power of these technologies and seeking to accelerate their impact, the U.S. Department of Energy’s Argonne National Laboratory has created two new collaborative centers that provide an innovative pathway for business and industry to access Argonne’s unparalleled scientific resources to address the nation’s energy and national security needs. These centers will help speed discoveries to market to ensure U.S. industry maintains a lead in this global technology race.

“This is an exciting time for us, because we believe this new approach to interacting with business can be a real game changer in two areas of research that are of great importance to Argonne and the world,” said Argonne Director Peter B. Littlewood. “We recognize that delivering to market our breakthrough science in energy storage and nanotechnology can help ensure our work brings the maximum benefit to society.”

Nano Design Works (NDW) and the Argonne Collaborative Center for Energy Storage Science (ACCESS) will provide central points of contact for companies — ranging from large industrial entities to smaller businesses and startups, as well as government agencies — to benefit from Argonne’s world-class expertise, scientific tools and facilities.

NDW and ACCESS represent a new way to collaborate at Argonne, providing a single point of contact for businesses to assemble tailored interdisciplinary teams to address their most challenging R&D questions. The centers will also provide a pathway to Argonne’s fundamental research that is poised for development into practical products. The chance to build on existing scientific discovery is a unique opportunity for businesses in the nano and energy storage fields.

The center directors, Andreas Roelofs of NDW and Jeff Chamberlain of ACCESS, have both created startups in their careers and understand the value that collaboration with a national laboratory can bring to a company trying to innovate in technologically challenging fields of science. While the new centers will work with all sizes of companies, a strong emphasis will be placed on helping small businesses and startups, which are drivers of job creation and receive a large portion of the risk capital in this country.

“For a startup like mine to have the ability to tap the resources of a place like Argonne would have been immensely helpful,” said Roelofs. “We”ve seen the power of that sort of access, and we want to make it available to the companies that need it to drive truly transformative technologies to market.”

Chamberlain said his experience as an energy storage researcher and entrepreneur led him to look for innovative approaches to leveraging the best aspects of private industry and public science. The national laboratory system has a long history of breakthrough science that has worked its way to market, but shortening that journey from basic research to product has become a growing point of emphasis for the national laboratories over the past couple of decades. The idea behind ACCESS and NDW is to make that collaboration even easier and more powerful.

“Where ACCESS and NDW will differ from the conventional approach is through creating an efficient way for a business to build a customized, multi-disciplinary team that can address anything from small technical questions to broad challenges that require massive resources,” Chamberlain said. “That might mean assembling a team with chemists, physicists, computer scientists, materials engineers, imaging experts, or mechanical and electrical engineers; the list goes on and on. It’s that ability to tap the full spectrum of cross-cutting expertise at Argonne that will really make the difference.”

Chamberlain is deeply familiar with the potential of energy storage as a transformational technology, having led the formation of Argonne’s Joint Center for Energy Storage Research (JCESR). The center’s years-long quest to discover technologies beyond lithium-ion batteries has solidified the laboratory’s reputation as one of the key global players in battery research. ACCESS will tap Argonne’s full battery expertise, which extends well beyond JCESR and is dedicated to fulfilling the promise of energy storage.

Energy storage research has profound implications for energy security and national security. Chamberlain points out that approximately 1.3 billion people across the globe do not have access to electricity, with another billion having only sporadic access. Energy storage, coupled with renewable generation like solar, could solve that problem and eliminate the need to build out massive power grids. Batteries also have the potential to create a more secure, stable grid for countries with existing power systems and help fight global climate disruption through adoption of renewable energy and electric vehicles.

Argonne researchers are pursuing hundreds of projects in nanoscience, but some of the more notable include research into targeted drugs that affect only cancerous cells; magnetic nanofibers that can be used to create more powerful and efficient electric motors and generators; and highly efficient water filtration systems that can dramatically reduce the energy requirements for desalination or cleanup of oil spills. Other researchers are working with nanoparticles that create a super-lubricated state and other very-low friction coatings.

“When you think that 30 percent of a car engine’s power is sacrificed to frictional loss, you start to get an idea of the potential of these technologies,” Roelofs said. “But it’s not just about the ideas already at Argonne that can be brought to market, it’s also about the challenges for businesses that need Argonne-level resources. I”m convinced there are many startups out there working on transformational ideas that can greatly benefit from the help of a place Argonne to bring those ideas to fruition. That is what has me excited about ACCESS and NDW.”

For more information on ACCESS, see: access.anl.gov

For more information on NDW, see: nanoworks.anl.gov

You can read more about the announcement in an Oct. 6, 2015 article by Greg Watry for R&D magazine featuring an interview with Andreas Roelofs.

Your grandma got STEM?

Jeff Bittel thank you for a story (Mar. 26, 2013 on Slate) about Rachel Levy and the website where she gently blows up the notion/stereotype that older women don’t understand science and technology and that they are too old to learn (Note: A link has been removed),

 Is your grandmother a particle physicist? Did she help the Navy build submarines or make concoctions of chlorine gas on the family’s front porch? Or is she a mathematician, inventor, or engineer? If so, then baby, your grandma’s got STEM.

Grandma Got STEM is a celebration of women working in and contributing to the fields of science, technology, engineering, and mathematics. It is also designed to combat the doting, fumbling, pie-making stereotype of grandmatrons.

That’s why Rachel Levy, an associate professor of mathematics at Harvey Mudd College, is collecting the stories of grandmas across the various fields of STEM. She first got the idea after hearing someone utter the phrase, “Just explain it like you would to your grandma.”

At first blush, such a thing seems harmless. But think about what it means—basically, all older women are stupid.

“For two or three years I thought about how I could address this issue without just making people angry and more inclined to use the phrase,” Levy told me. “If I could come up with a million examples of grandmothers who were tech-savvy, people wouldn’t say it anymore because it wouldn’t be apt.”

While attending the conference ScienceOnline this year, Levy realized she could harness the power of the Internet to collect stories and showcase them. So far, she’s been able to upload at least one grandma a day for about a month and a half—and the stories keep pouring in. Levy’s aim so far is to be as inclusive as possible. She’s accepting any grandma currently or previously involved in STEM. They can submit themselves or you can submit for them. Heck, they don’t even have to have children with children, per se. Age’ll do just fine.

Bittel might want to reconsider that bit about children and children with children. That can be a touchy topic.

Levy’s solution was to create the Grandma Got STEM website. From the Mar. 27, 2013 posting about Mary Vellos Klonowski,


Thank you to undergraduate Math/Computer Science Major Joey Klonowski, who submitted this post about his grandmother:

This photo is from the October 3, 1951 edition of The Southtown Economist, a daily newspaper on the South Side of Chicago, when my grandmother, Mary Klonowski, was 18. She attended DePaul University against the wishes of her father, who didn’t want his daughters to be college educated. She received a BS from DePaul in 1954 and was the only woman chemistry major in her class. She later earned a master’s in mathematics education and became a high school math teacher. She is now 80 years old and still working as a substitute teacher.

There are a lot of stories (covering quite the range of grannies) on the site. Levy is asking for international submissions as well,

Seeking international submissions!

You can help promote this project by sharing the posts on your blog, Facebook wall, or by retweeting them.

The project has readers from more than 100 countries, but submissions from only a few.  Please help make this blog an international effort by submitting posts or encouraging others to post.

Call for submissions – short

Know any geeky grannies?  Seeking submissions for Grandma got STEM.  Email name+pic+story to ggstem@hmc.edu.

Call for submissions – long

Call for submissions – Grandma got STEM.  Are you a grandmother working in a STEM (Science, Technology, Engineering, Mathematics) – related field?  Know any geeky grannies?  Email name+pic+story/remembrance to Rachel Levy:  ggstem (at) hmc (dot) edu.  Follow on Twitter: @mathcirque #ggstem  Project site:http://ggstem.wordpress.com

Presumably, the submissions need to be in English.

Getting back to Bittel’s Slate article, he mentions Foldit (here’s my first piece in an Aug. 6, 2010 posting [scroll down about 1/2 way]), a protein-folding game which has generated some very exciting science. He also notes some of that science was generated by older, ‘uneducated’ women. Bittel linked to Jeff Howe’s Feb. 27, 2012 article about Foldit and other crowdsourced science projects for Slate where I found this very intriguing bit,

“You’d think a Ph.D. in biochemistry would be very good at designing protein molecules,” says Zoran Popović, the University of Washington game designer behind Foldit. Not so. “Biochemists are good at other things. But Foldit requires a narrow, deeper expertise.”

Or as it turns out, more than one. Some gamers have a preternatural ability to recognize patterns, an innate form of spatial reasoning most of us lack. Others—often “grandmothers without a high school education,” says Popovic—exercise a particular social skill. “They’re good at getting people unstuck. They get them to approach the problem differently.” What big pharmaceutical company would have anticipated the need to hire uneducated grandmothers? (I know a few, if Eli Lilly HR is thinking of rejiggering its recruitment strategy.) [emphases mine]

There’s an interesting question and I didn’t see it answered in Howe’s article. What kind of grandmother who doesn’t have high school graduation joins a protein-folding game? I ask because neither of my parents had or have a high school education. Neither of them would have joined the game as neither would have had the confidence.

What I’ve tried to present here is a range of possibilities regarding age and education. Being older (female especially but also male, on occasion) doesn’t equal stupidity. As for education, I’ve never found that having high school graduation or a university degree(s) to be a guarantor of an exciting intellect. I mention these two points because it seems to me that people are being ranked as to age and education in ways that are unnecessarily exclusionary. Thank goodness for games like Foldit and websites like Grandma’s Got STEM which suggest alternatives to this relentless and ruthless form of ranking which disallows participation from the great bulk of us.