Tag Archives: amyotrophic lateral sclerosis (ALS)

Stephen Hawking comic updates ‘Stephen Hawking: Riddles of Time & Space’ and adds life story for a tribute issue

Artist: Robert Aragon. Courtesy: TidalWave Productions

It would seem I wasn’t having one of my brighter days today (Feb. 7, 2019) and it took me a while to to decode the messaging about this Stephen Hawking comic book. Briefly, they’ve (TidalWave Productions; Note: The company seems to have more than one name) repackaged an old title (Stephen Hawking: Riddles of Time & Space) and included new material in the form of his life story. After some searching, as best as I can tell, the ‘Tribute’ was originally released sometime in 2018 in a digital version. This latest push for publicity was likely occasioned by the release of a print version.

Here’s more from a February 7, 2019 TidalWave Entertainment/Bluewater Productions news release (received via email),

TidalWave Comics, applauded for illustrated biographies featuring the
famous and infamous who influence our politics, entertainment, and
social justice, is proud to present its newest comic book release this
week. Telling the life story of a world-renowned physicist, cosmologist,
and author Stephen Hawking, “Tribute: Stephen Hawking,” is written
by Michael Lent, Brian McCarthy and Michael Frizell with art by Zach
Bassett. The comic book features a cover by famed artist Robert Aragon.

“Tribute: Stephen Hawking” is out this week in print and digital.
With the passing of English cosmologist, theoretical physicist, and
author, the world has lost one of the greatest scientific minds of the
20th and 21st Centuries. Hawking united the general theory of relativity
with quantum mechanics but may be more known for his rare, early-onset
and slow-progressing battle with Lou Gehrig’s disease. Hawking believed
in the concept of an infinite multiverse. Perhaps he’s watching us
mourn his loss.

Stephen Hawking is one of the most brilliant minds of this century. The
comic explores his brilliance while revealing some surprises.

Hawking’s life has been the subject of several movies, including the
2014 hit, “The Theory of Everything” starring Eddy Redmayne, who
received an Oscar and a Golden Globe for his performance as the
scientist dealing with an early-onset slow-progressing form of Lou
Gehrig’s disease. The comic seeks to add to Hawking’s story.

“I learned a lot from reading the script and doing the research for the
issue.  The very concept of making an engaging comic book where the
protagonist is essentially immobile is a pretty tall order, but I think
the key to us keeping it exciting was being able to get inside his mind
(one of the greatest of our time) and show some of his most abstract
concepts in a visual and dynamic way,” said artist Bassett.

Darren G. Davis, publisher and creative force behind TidalWave, believes
as Bassett does that the visual storytelling model is a good way to tell
the stories of real people. “I was a reluctant reader when I was a
kid. The colorful pages and interesting narrative I found in comic books
drew me in and made me want to read.” In a market crowded with
superheroes, the publisher’s work is embraced by major media outlets,
libraries, and schools.

Michael Frizell, one of TidalWave’s writers and the author of the
Bettie Page comic, enjoys writing for TidalWave’s biography lines
Political Power, Orbit, Female Force, Tribute, and Fame because of the
publisher’s approach to the books. “Darren asks us to focus on the
positive and to dig deep to explore the things that make the subject
tick – the things that drive them,” Frizell said.

In print on Amazon and are available on your e-reader from iTunes,
Kindle, Nook, ComiXology, DriveThru Comics, Google Play, Overdrive,
IVerse, Biblioboard, Madefire, Axis360, Blio, Entitle, EPIC!,
Trajectory, SpinWhiz, Smash Words, Kobo and wherever eBooks are sold.

TidalWave’s recent partnership with Ingram allows them to produce
high-quality books on demand – a boon for the independent publisher. The
comic book will feature a heavy-stock cover and bright, clean colors in
the interior. Ingram works across the full publishing spectrum, aiding
some of the largest names in the business to local indie authors.

Comic book and book stores can order these titles in print at INGRAM.

TidalWave’s biography comic book series has been embraced by the media
and featured on television news outlets including The Today Show and on
CNN. The series has also been featured in many publications such as The
Los Angeles Times, MTV, Time Magazine, and People Magazine.


For more information about the company, visit www.tidalwavecomics.com
 
About TidalWave Comics
TidalWave delivers a multimedia experience unparalleled in the burgeoning graphic fiction and nonfiction marketplace. Dynamic storytelling coupled with groundbreaking art delivers an experience like no other. Stories are told through multiple platforms and genres, gracing the pages of graphic novels, novelizations, engaging audio dramas, cutting-edge film projects, and more. Diversity defines Storm’s offerings in the burgeoning pop culture marketplace, offering fresh voices and innovative storytellers.

As one of the top independent publishers of comic book and graphic novels, TidalWave unites cutting-edge art and engaging stories produced by the publishing industry’s most exciting artists and writers. Its extensive catalog of comic book titles includes the bestsellers “10th Muse” and “The Legend of Isis,” complemented by a line of young adult books and audiobooks. TidalWave’s publishing partnerships include legendary filmmaker Ray Harryhausen (“Wrath of the Titans,” “Sinbad: Rogue of Mars,” “Jason and the Argonauts,” and more), novelists S.E. Hinton (“The Puppy Sister”) and William F. Nolan (“Logan’s Run”), and celebrated actors Vincent Price (“Vincent Price Presents”), and Adam West of 1966’s “Batman” fame (“The Mis-Adventures of Adam West”). TidalWave also publishes a highly-successful line of biographical comics under the titles “Orbit,” “Fame,” “Beyond,” “Tribute,” “Female Force,” and “Political Power.”

Should you happen to operate a comic and/or book store, I have found the Ingram (Content Group) website. Happy ordering!

Democratizing science .. neuroscience that is

What is going on with the neuroscience folks? First it was Montreal Neuro opening up its science  as featured in my January 22, 2016 posting,

The Montreal Neurological Institute (MNI) in Québec, Canada, known informally and widely as Montreal Neuro, has ‘opened’ its science research to the world. David Bruggeman tells the story in a Jan. 21, 2016 posting on his Pasco Phronesis blog (Note: Links have been removed),

The Montreal Neurological Institute (MNI) at McGill University announced that it will be the first academic research institute to become what it calls ‘Open Science.’  As Science is reporting, the MNI will make available all research results and research data at the time of publication.  Additionally it will not seek patents on any of the discoveries made on research at the Institute.

Will this catch on?  I have no idea if this particular combination of open access research data and results with no patents will spread to other university research institutes.  But I do believe that those elements will continue to spread.  More universities and federal agencies are pursuing open access options for research they support.  Elon Musk has opted to not pursue patent litigation for any of Tesla Motors’ patents, and has not pursued patents for SpaceX technology (though it has pursued litigation over patents in rocket technology). …

Whether or not they were inspired by the MNI, the scientists at the University of Washington (UW [state]) have found their own unique way of opening up science. From a March 15, 2018 UW news blog posting (also on EurekAlert) by James Urton, Note: Links have been removed,

Over the past few years, scientists have faced a problem: They often cannot reproduce the results of experiments done by themselves or their peers.

This “replication crisis” plagues fields from medicine to physics, and likely has many causes. But one is undoubtedly the difficulty of sharing the vast amounts of data collected and analyses performed in so-called “big data” studies. The volume and complexity of the information also can make these scientific endeavors unwieldy when it comes time for researchers to share their data and findings with peers and the public.

Researchers at the University of Washington have developed a set of tools to make one critical area of big data research — that of our central nervous system — easier to share. In a paper published online March 5 [2018] in Nature Communications, the UW team describes an open-access browser they developed to display, analyze and share neurological data collected through a type of magnetic resonance imaging study known as diffusion-weighted MRI.

“There has been a lot of talk among researchers about the replication crisis,” said lead author Jason Yeatman. “But we wanted a tool — ready, widely available and easy to use — that would actually help fight the replication crisis.”

Yeatman — who is an assistant professor in the UW Department of Speech & Hearing Sciences and the Institute for Learning & Brain Sciences (I-LABS) — is describing AFQ-Browser. This web browser-based tool, freely available online, is a platform for uploading, visualizing, analyzing and sharing diffusion MRI data in a format that is publicly accessible, improving transparency and data-sharing methods for neurological studies. In addition, since it runs in the web browser, AFQ-Browser is portable — requiring no additional software package or equipment beyond a computer and an internet connection.

“One major barrier to data transparency in neuroscience is that so much data collection, storage and analysis occurs on local computers with special software packages,” said senior author Ariel Rokem, a senior data scientist in the UW eScience Institute. “But using AFQ-Browser, we eliminate those requirements and make uploading, sharing and analyzing diffusion-weighted MRI data a simple, straightforward process.”

Diffusion-weighted MRI measures the movement of fluid in the brain and spinal cord, revealing the structure and function of white-matter tracts. These are the connections of the central nervous system, tissue that are made up primarily of axons that transmit long-range signals between neural circuits. Diffusion MRI research on brain connectivity has fundamentally changed the way neuroscientists understand human brain function: The state, organization and layout of white matter tracts are at the core of cognitive functions such as memory, learning and other capabilities. Data collected using diffusion-weighted MRI can be used to diagnose complex neurological conditions such as multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). Researchers also use diffusion-weighted MRI data to study the neurological underpinnings of conditions such as dyslexia and learning disabilities.

“This is a widely-used technique in neuroscience research, and it is particularly amenable to the benefits that can be gleaned from big data, so it became a logical starting point for developing browser-based, open-access tools for the field,” said Yeatman.

The AFQ-Browser — the AFQ stands for Automated Fiber-tract Quantification — can receive diffusion-weighted MRI data and perform tract analysis for each individual subject. The analyses occur via a remote server, again eliminating technical and financial barriers for researchers. The AFQ-Browser also contains interactive tools to display data for multiple subjects — allowing a researcher to easily visualize how white matter tracts might be similar or different among subjects, identify trends in the data and generate hypotheses for future experiments. Researchers also can insert additional code to analyze the data, as well as save, upload and share data instantly with fellow researchers.

“We wanted this tool to be as generalizable as possible, regardless of research goals,” said Rokem. “In addition, the format is easy for scientists from a variety of backgrounds to use and understand — so that neuroscientists, statisticians and other researchers can collaborate, view data and share methods toward greater reproducibility.”

The idea for the AFQ-Browser came out of a UW course on data visualization, and the researchers worked with several graduate students to develop and perfect the browser. They tested it on existing diffusion-weighted MRI datasets, including research subjects with ALS and MS. In the future, they hope that the AFQ-Browser can be improved to do automated analyses — and possibly even diagnoses — based on diffusion-weighted MRI data.

“AFQ-Browser is really just the start of what could be a number of tools for sharing neuroscience data and experiments,” said Yeatman. “Our goal here is greater reproducibility and transparency, and a more robust scientific process.”

Here are a couple of images the researchers have used to illustrate their work,

AFQ-Browser.Jason Yeatman/Ariel Rokem Courtesy: University of Washington

Depiction of the left hemisphere of the human brain. Colored regions are selected white matter regions that could be measured using diffusion-weighted MRI: Corticospinal tract (orange), arcuate fasciculus (blue) and cingulum (green).Jason Yeatman/Ariel Rokem

You can find an embedded version of the AFQ-Browser here: http://www.washington.edu/news/2018/03/15/democratizing-science-researchers-make-neuroscience-experiments-easier-to-share-reproduce/ (scroll down about 50 – 55% of the way).

As for the paper, here’s a link and a citation,

A browser-based tool for visualization and analysis of diffusion MRI data by Jason D. Yeatman, Adam Richie-Halford, Josh K. Smith, Anisha Keshavan, & Ariel Rokem. Nature Communicationsvolume 9, Article number: 940 (2018) doi:10.1038/s41467-018-03297-7 Published online: 05 March 2018

Fittingly, this paper is open access.