Tag Archives: Andrew Maynard

A couple of lawyers talk wrote about managing nanotechnology risks

Because they are lawyers, I was intrigued by a Nov. 4, 2015 article on managing nanotechnology risks by Michael Lisak and James Mizgala of Sidley Austin LLP for Industry Week. I was also intrigued by the language (Note: A link has been removed),

The inclusion of nanotechnologies within manufacturing processes and products has increased exponentially over the past decade. Fortune recently noted that nanotechnology touches almost all Fortune 500 companies and that the industry’s $20 billion worldwide size is expected to double over the next decade. [emphasis mine]

Yet, potential safety issues have been raised and regulatory uncertainties persist. As such, proactive manufacturers seeking to protect their employees, consumers, the environment and their businesses – while continuing to develop, manufacture and market their products – may face difficult choices in how to best navigate this challenging and fluid landscape, while avoiding potential “nanotort,”  [emphasis mine] whistleblower, consumer fraud and regulatory enforcement lawsuits. Doing so requires forward-thinking advice based upon detailed analyses of each manufacturer’s products and conduct in the context of rapidly evolving scientific, regulatory and legal developments.

I wonder how many terms lawyers are going to coin in addition to “nanotort”?

The lawyers focus largely on two types of nanoparticles, carbon nanotubes, with a special emphasis on multi-walled carbon nantubes (MWCNT) and nano titanium dioxide,

Despite this scientific uncertainty, international organizations, such as the International Agency for Research on Cancer [a World Health Organization agency], have already concluded that nano titanium dioxide in its powder form and multi-walled carbon nanotube-7 (“MWCNT-7”) [emphasis mine] are “possibly carcinogenic to humans.” As such, California’s Department of Public Health lists titanium dioxide and MWCNT-7 as “ingredients known or suspected to cause cancer, birth defects, or other reproductive toxicity as determined by the authoritative scientific bodies.”  Considering that processed (i.e., non-powdered) titanium dioxide is found in products like toothpaste, shampoo, chewing gum and candies, it is not surprising that some have focused upon such statements.

There’s a lot of poison in the world, for example, apples contain seeds which have arsenic in them and, for another, peanuts can be carcinogenic and they can also kill you, as they are poison to people who are allergic to them.

On the occasion of Dunkin’ Donuts removing nano titanium dioxide as an ingredient in the powdered sugar used to coat donuts, I wrote a March 13, 2015 posting, where I quote extensively from Dr. Andrew Maynard’s (then director of the University of Michigan Risk Science Center now director of the Risk Innovation Lab at Arizona State University) 2020 science blog posting about nano titanium dioxide and Dunkin’ Donuts,

He describes some of the research on nano titanium dioxide (Note: Links have been removed),

… In 2004 the European Food Safety Agency carried out a comprehensive safety review of the material. After considering the available evidence on the same materials that are currently being used in products like Dunkin’ Donuts, the review panel concluded that there no evidence for safety concerns.

Most research on titanium dioxide nanoparticles has been carried out on ones that are inhaled, not ones we eat. Yet nanoparticles in the gut are a very different proposition to those that are breathed in.

Studies into the impacts of ingested nanoparticles are still in their infancy, and more research is definitely needed. Early indications are that the gastrointestinal tract is pretty good at handling small quantities of these fine particles. This stands to reason given the naturally occurring nanoparticles we inadvertently eat every day, from charred foods and soil residue on veggies and salad, to more esoteric products such as clay-baked potatoes. There’s even evidence that nanoparticles occur naturally inside the gastrointestinal tract.

You can find Andrew’s entire discussion in his March 12, 2015 post on the 2020 Science blog. Andrew had written earlier in a July 12, 2014 posting about something he terms ‘nano donut math’ as reported by As You Sow, the activist group that made a Dunkin’ Donuts shareholder proposal which resulted in the company’s decision to stop using nano titanium dioxide in the powdered sugar found on their donuts. In any event, Andrew made this point,

In other words, if a Dunkin’ Donut Powdered Cake Donut contained 8.9 mg of TiO2 particles smaller than 10 nm, it would have to have been doused with over 1 million tons of sugar coating! (Note update at the end of this piece)

Clearly something’s wrong here – either Dunkin’ Donuts are not using food grade TiO2 but a nanopowder with particle so small they would be no use whatsoever in the sugar coating (as well as being incredibly expensive, and not FDA approved).  Or there’s something rather wrong with the analysis!

If it’s the latter – and it’s hard to imagine any other plausible reason for the data – it looks like As You Sow ended up using rather dubious figures to back up their stakeholder resolution.  I’d certainly be interested in more information on the procedures Analytical Sciences used and the checks and balances they had in place, especially as there are a number of things that can mess up a particle analysis like this.

Update July 14: My bad, I made a slight error in the size distribution calculation first time round.  This has been corrected in the article above.  Originally, I cited the estimated Mass Median Diameter (MMD) of the TiO2 particles as 167 nm, and the Geometric Standard Deviation (GSD) as 1.6.  Correcting an error in the Excel spreadsheet used to calculate the distribution (these things happen!) led to a revised estimate of MMD = 168 nm and a GSD of 1.44.  These may look like subtle differences, but when calculating the estimated particle mass below 10 nm, they make a massive difference.  With the revised figures, you’d expect less than one trillionth of  a percent of the mass of the TiO2 powder to be below 10 nm!! (the original estimate was a tenth of a millionth of a percent).  In other words – pretty much nothing!  The full analysis can be found here.

Update November 16 2014.  Based on this post, As You Sow checked the data from Analytical Sciences LLC and revised the report accordingly.  This is noted above.

It would seem that if there are concerns over nano titanium dioxide in food, the biggest would not be the amounts ingested by consumers but inhalation by workers should they breathe in large quantities when they are handling the material.

As for the MWCNTs, they have long raised alarms but most especially the long MWCNTs and for people handling them during the course of their work day. Any MWCNTs found in sports equipment and other consumer products are bound in the material and don’t pose any danger of being inhaled into the lungs, unless they should be released from their bound state (e.g. fire might release them).

After some searching for MWCNT-7, I found something which seems also to be known as Mitsui MWCNT-7 or Mitsui 7-MWCNT (here’s one of my sources). As best I understand it, Mitsui is a company that produces an MWCNT which they have coined an MWCNT-7 and which has been used in nanotoxicity testing. As best I can tell, MWCNT is MWCNT-7.

The lawyers (Lisak and Mizgala) note things have changed for manufacturers since the early days and they make some suggestions,

One thing is certain – gone are the days when “sophisticated” manufacturers incorporating nanotechnologies within their products can reasonably expect to shield themselves by pointing to scientific and regulatory uncertainties, especially given the amount of money they are spending on research and development, as well as sales and marketing efforts.

Accordingly, manufacturers should consider undertaking meaningful risk management analyses specific to their applicable products. …

First, manufacturers should fully understand the life-cycle of nanomaterials within their organization. For some, nanomaterials may be an explicit focus of innovation and production, making it easier to pinpoint where nanotechnology fits into their processes and products. For others, nanomaterials may exist either higher-up or in the back-end of their products’ supply chain. …

Second, manufacturers should understand and stay current with the scientific state-of-the-art as well as regulatory requirements and developments potentially applicable to their employees, consumers and the environment. An important consideration related to efforts to understand the state-of-the-art is whether or not manufacturers should themselves expend resources to advance “the science” in seeking to help find answers to some of the aforementioned uncertainties. …

The lawyers go on to suggest that manufacturers should consider proactively researching nanotoxicity so as to better defend themselves against any future legal suits.

Encouraging companies to proactive with toxicity issues is in line with what seems to be an international (Europe & US) regulatory movement putting more onus on producers and manufacturers to take responsibility for safety testing. (This was communicated to me in a conversation I had with an official at the European Union Joint Research Centre where he mentioned REACH regulations and the new emphasis in response to my mention of similar FDA (US Food and Drug Administration) regulations. (We were at the 2014 9th World Congress on Alternatives to Animal Testing in Prague, Czech republic.)

For anyone interested in the International Agency for Research on Cancer you can find it here.

Inadvertent carbon nanotube production from your car

It’s disconcerting to find out that cars inadvertently produce carbon nanotubes which are then spilled into the air we breathe. Researchers at Rice University (US) and Paris-Saclay University (France) have examined matter from car exhausts and dust in various parts of Paris finding carbon nanotubes (CNTs). Further, they also studied the lungs of Parisian children who have asthma and found CNTs there too.

The scientists have carefully stated that CNTs have been observed in lung cells but they are not claiming causality (i.e., they don’t claim the children’s asthma was caused by CNTs).

An Oct. 20, 2015 news item on Nanotechnology Now introduces the research,

Cars appear to produce carbon nanotubes, and some of the evidence has been found in human lungs.

Rice University scientists working with colleagues in France have detected the presence of man-made carbon nanotubes in cells extracted from the airways of Parisian children under routine treatment for asthma. Further investigation found similar nanotubes in samples from the exhaust pipes of Paris vehicles and in dust gathered from various places around the city.

The researchers reported in the journal EBioMedicine this month that these samples align with what has been found elsewhere, including Rice’s home city of Houston, in spider webs in India and in ice cores.

An Oct. 19, 2015 Rice University news release (also on EurekAlert), which originated the news item, painstakingly describes the work and initial conclusions,

The research in no way ascribes the children’s conditions to the nanotubes, said Rice chemist Lon Wilson, a corresponding author of the new paper. But the nanotubes’ apparent ubiquity should be the focus of further investigation, he said.

“We know that carbon nanoparticles are found in nature,” Wilson said, noting that round fullerene molecules like those discovered at Rice are commonly produced by volcanoes, forest fires and other combustion of carbon materials. “All you need is a little catalysis to make carbon nanotubes instead of fullerenes.”

A car’s catalytic converter, which turns toxic carbon monoxide into safer emissions, bears at least a passing resemblance to the Rice-invented high-pressure carbon monoxide, or HiPco, process to make carbon nanotubes, he said. “So it is not a big surprise, when you think about it,” Wilson said.

The team led by Wilson, Fathi Moussa of Paris-Saclay University and lead author Jelena Kolosnjaj-Tabi, a graduate student at Paris-Saclay, analyzed particulate matter found in the alveolar macrophage cells (also known as dust cells) that help stop foreign materials like particles and bacteria from entering the lungs.

The researchers wrote that their results “suggest humans are routinely exposed” to carbon nanotubes. They also suggested previous studies that link the carbon content of airway macrophages and the decline of lung function should be reconsidered in light of the new findings. Moussa confirmed his lab will continue to study the impact of man-made nanotubes on health.

The cells were taken from 69 randomly selected asthma patients aged 2 to 17 who underwent routine fiber-optic bronchoscopies as part of their treatment. For ethical reasons, no cells from healthy patients were analyzed, but because nanotubes were found in all of the samples, the study led the researchers to conclude that carbon nanotubes are likely to be found in everybody.

The study notes but does not make definitive conclusions about the controversial proposition that carbon nanotube fibers may act like asbestos, a proven carcinogen. But the authors reminded that “long carbon nanotubes and large aggregates of short ones can induce a granulomatous (inflammation) reaction.”

The study partially answers the question of what makes up the black material inside alveolar macrophages, the original focus of the study. The researchers found single-walled and multiwalled carbon nanotubes and amorphous carbon among the cells, as well as in samples swabbed from the tailpipes of cars in Paris and dust from various buildings in and around the city.

The news release goes on to detail how the research was conducted,

“The concentrations of nanotubes are so low in these samples that it’s hard to believe they would cause asthma, but you never know,” Wilson said. “What surprised me the most was that carbon nanotubes were the major component of the carbonaceous pollution we found in the samples.”

The nanotube aggregates in the cells ranged in size from 10 to 60 nanometers in diameter and up to several hundred nanometers in length, small enough that optical microscopes would not have been able to identify them in samples from former patients. The new study used more sophisticated tools, including high-resolution transmission electron microscopy, X-ray spectroscopy, Raman spectroscopy and near-infrared fluorescence microscopy to definitively identify them in the cells and in the environmental samples.

“We collected samples from the exhaust pipes of cars in Paris as well as from busy and non-busy intersections there and found the same type of structures as in the human samples,” Wilson said.

“It’s kind of ironic. In our laboratory, working with carbon nanotubes, we wear facemasks to prevent exactly what we’re seeing in these samples, yet everyone walking around out there in the world probably has at least a small concentration of carbon nanotubes in their lungs,” he said.

The researchers also suggested that the large surface areas of nanotubes and their ability to adhere to substances may make them effective carriers for other pollutants.

The study followed one released by Rice and Baylor College of Medicine earlier this month with the similar goal of analyzing the black substance found in the lungs of smokers who died of emphysema. That study found carbon black nanoparticles that were the product of the incomplete combustion of such organic material as tobacco.

Here’s an image of a sample,

 Caption: Carbon nanotubes (the long rods) and nanoparticles (the black clumps) appear in vehicle exhaust taken from the tailpipes of cars in Paris. The image is part of a study by scientists in Paris and at Rice University to analyze carbonaceous material in the lungs of asthma patients. They found that cars are a likely source of nanotubes found in the patients. Credit: Courtesy of Fathi Moussa/Paris-Saclay University

Caption: Carbon nanotubes (the long rods) and nanoparticles (the black clumps) appear in vehicle exhaust taken from the tailpipes of cars in Paris. The image is part of a study by scientists in Paris and at Rice University to analyze carbonaceous material in the lungs of asthma patients. They found that cars are a likely source of nanotubes found in the patients.
Credit: Courtesy of Fathi Moussa/Paris-Saclay University

Here’s a link to and a citation for the paper,

Anthropogenic Carbon Nanotubes Found in the Airways of Parisian Children by Jelena Kolosnjaj-Tabi, Jocelyne Just, Keith B. Hartman, Yacine Laoudi, Sabah Boudjemaa, Damien Alloyeau, Henri Szwarc, Lon J. Wilson, & Fathi Moussa. EBioMedicine doi:10.1016/j.ebiom.2015.10.012 Available online 9 October 2015

This paper is open access.

ETA Oct. 26, 2015: Dexter Johnson, along with Dr. Andrew Maynard, provides an object lesson on how to read science research in an Oct. 23, 2015 posting on his Nanoclast blog (on the IEEE [Institute of Electrical and Electronics Engineers]),

“From past studies, the conditions in combustion engines seem to favor the production of at least some CNTs (especially where there are trace metals in lubricants that can act as catalysts for CNT growth),” explained Andrew Maynard Director, Risk Innovation Lab and Professor, School for the Future of Innovation in Society at Arizona State University, in an e-mail interview. Says Maynard:

What, to my knowledge, is still not known, is the relative concentrations of CNT in ambient air that may be inhaled, the precise nature of these CNT in terms of physical and chemical structure, and the range of sources that may lead to ambient CNT. This is important, as the potential for fibrous particles to cause lung damage depends on characteristics such as their length—and many of the fibers shown in the paper appear too short to raise substantial concerns.”

Nonetheless, Maynard praises the research for establishing that these carbon nanotube-like fibers are part of the urban aerosol and therefore end up in the lungs of anyone who breathes it in. However, he cautions that the findings don’t provide information on the potential health risks associated with these exposures.

It’s a good read not only for the information but the mild snarkiness (assuming you find that kind of thing amusing) that spices up the piece.

Safer sunblock and bioadhesive nanoparticles from Yale University

The skin has a lot of protective barriers but it’s always possible to make something better so a sunblock that doesn’t penetrate teh skin at all seems like it might be a good thing. Interestingly, this new sunblock or sunscreen is enabled by nanoparticles but not the metallic nanoparticles found in what are sometimes called nanosunscreens. From a Sept. 29, 2015 news item on Nanowerk,

Researchers at Yale have developed a sunscreen that doesn’t penetrate the skin, eliminating serious health concerns associated with commercial sunscreens.

Most commercial sunblocks are good at preventing sunburn, but they can go below the skin’s surface and enter the bloodstream. As a result, they pose possible hormonal side effects and could even be promoting the kind of skin cancers they’re designed to prevent.

But researchers at Yale have developed a new sunblock, made with bioadhesive nanoparticles, that stays on the surface of the skin.

A Sept. 28, 2015 Yale University news release by William Weir, whch originated the news item, describes the research in more detail,

“We found that when we apply the sunblock to the skin, it doesn’t come off, and more importantly, it doesn’t penetrate any further into the skin,” said the paper’s senior author, Mark Saltzman, the Goizueta Foundation Professor of Biomedical Engineering. “Nanoparticles are large enough to keep from going through the skin’s surface, and our nanoparticles are so adhesive that they don’t even go into hair follicles, which are relatively open.”

Using mouse models, the researchers tested their sunblock against direct ultraviolet rays and their ability to cause sunburn. In this regard, even though it used a significantly smaller amount of the active ingredient than commercial sunscreens, the researchers’ formulation protected equally well against sunburn.

They also looked at an indirect — and much less studied — effect of UV light. When the active ingredients of sunscreen absorb UV light, a chemical change triggers the generation of oxygen-carrying molecules known as reactive oxygen species (ROS). If a sunscreen’s agents penetrate the skin, this chemical change could cause cellular damage, and potentially facilitate skin cancer.

“Commercial chemical sunblock is protective against the direct hazards of ultraviolet damage of DNA, but might not be against the indirect ones,” said co-author Michael Girardi, a professor of dermatology at Yale Medical School. “In fact, the indirect damage was worse when we used the commercial sunblock.”

Girardi, who specializes in skin cancer development and progression, said little research has been done on the ultimate effects of sunblock usage and the generation of ROS, “but obviously, there’s concern there.”

Previous studies have found traces of commercial sunscreen chemicals in users’ bloodstreams, urine, and breast milk. There is evidence that these chemicals cause disruptions with the endocrine system, such as blocking sex hormone receptors.

To test penetration levels, the researchers applied strips of adhesive tape to skin previously treated with sunscreen. The tape was then removed rapidly, along with a thin layer of skin. Repeating this procedure allowed the researchers to remove the majority of the outer skin layer, and measure how deep the chemicals had penetrated into the skin. Traces of the sunscreen chemical administered in a conventional way were found to have soaked deep within the skin. The Yale team’s sunblock came off entirely with the initial tape strips.

Tests also showed that a substantial amount of the Yale team’s sunscreen remained on the skin’s surface for days, even after exposure to water. When wiped repeatedly with a towel, the new sunblock was entirely removed. [emphasis mine]

To make the sunblock, the researchers developed a nanoparticle with a surface coating rich in aldehyde groups, which stick tenaciously to the outer skin layer. The nanoparticle’s hydrophilic layer essentially locks in the active ingredient, a hydrophobic chemical called padimate O.

Some sunscreen solutions that use larger particles of inorganic compounds, such as titanium dioxide or zinc oxide, also don’t penetrate the skin. For aesthetic reasons, though, these opaque sunscreen products aren’t very popular. By using a nanoparticle to encase padimate O, an organic chemical used in many commercial sunscreens, the Yale team’s sunblock is both transparent and stays out of the skin cells and bloodstream.

This seems a little confusing to me and I think clarification may be helpful. My understanding is that the metallic nanoparticles (nano titanium dioxide and nano zinc oxide) engineered for use in commercial sunscreens are also (in addition to the macroscale titanium dioxide and zinc oxide referred to in the Yale news release) too large to pass through the skin. At least that was the understanding in 2010 and I haven’t stumbled across any information that is contradictory. Here’s an excerpt from a July 20, 2010 posting where I featured portions of a debate between Georgia Miller (at that time representing Friends of the Earth) and Dr. Andrew Maynard (at that time director of the University of Michigan Risk Science Center and a longtime participant in the nanotechnology risk discussions),

Three of the scientists whose work was cited by FoE as proof that nanosunscreens are dangerous either posted directly or asked Andrew to post comments which clarified the situation with exquisite care,

Despite FoE’s implications that nanoparticles in sunscreens might cause cancer because they are photoactive, Peter Dobson points out that there are nanomaterials used in sunscreens that are designed not to be photoactive. Brian Gulson, who’s work on zinc skin penetration was cited by FoE, points out that his studies only show conclusively that zinc atoms or ions can pass through the skin, not that nanoparticles can pass through. He also notes that the amount of zinc penetration from zinc-based sunscreens is very much lower than the level of zinc people have in their body in the first place. Tilman Butz, who led one of the largest projects on nanoparticle penetration through skin to date, points out that – based on current understanding – the nanoparticles used in sunscreens are too large to penetrate through the skin.

However, there may be other ingredients which do pass through into the bloodstream and are concerning.

One other thing I’d like to note. Not being able to remove the sunscreen easily ( “When wiped repeatedly with a towel, the new sunblock was entirely removed.”) may prove to be a problem as we need Vitamin D, which is for the most part obtainable by sun exposure.

In any event, here’s a link to and a citation for the paper,

A sunblock based on bioadhesive nanoparticles by Yang Deng, Asiri Ediriwickrema, Fan Yang, Julia Lewis, Michael Girardi, & W. Mark Saltzman. Nature Materials (2015) doi:10.1038/nmat4422 Published online 28 September 2015

This paper is behind a paywall.

Risk assessments not the only path to nanotechnology regulation

Nanowerk has republished an essay about nanotechnology regulation from Australia’s The Conversation in an Aug. 25, 2015 news item (Note: A link has been removed),

When it comes to nanotechnology, Australians have shown strong support for regulation and safety testing.

One common way of deciding whether and how nanomaterials should be regulated is to conduct a risk assessment. This involves calculating the risk a substance or activity poses based on the associated hazards or dangers and the level of exposure to people or the environment.

However, our recent review (“Risk Analysis of Nanomaterials: Exposing Nanotechnology’s Naked Emperor”) found some serious shortcomings of the risk assessment process for determining the safety of nanomaterials.

We have argued that these shortcomings are so significant that risk assessment is effectively a naked emperor [reference to a children’s story “The Emperor’s New Clothes“].

The original Aug. 24, 2015 article written by Fern Wickson (Scientist/Program Coordinator at GenØk – Centre for Biosafety in Norway) and Georgia Miller (PhD candidate at UNSW [University of New South Wales], Australia) points out an oft ignored issue with regard to nanotechnology regulation,

Risk assessment has been the dominant decision-aiding tool used by regulators of new technologies for decades, despite it excluding key questions that the community cares about. [emphasis mine] For example: do we need this technology; what are the alternatives; how will it affect social relations, and; who should be involved in decision making?

Wickson and Miller also note more frequently discussed issues,

A fundamental problem is a lack of nano-specific regulation. Most sector-based regulation does not include a “trigger” for nanomaterials to face specific risk assessment. Where a substance has been approved for use in its macro form, it requires no new assessment.

Even if such a trigger were present, there is also currently no cross-sectoral or international agreement on the definition of what constitutes a nanomaterial.

Another barrier is the lack of measurement capability and validated methods for safety testing. We still do not have the means to conduct routine identification of nanomaterials in the complex “matrix” of finished products or the environment.

This makes supply chain tracking and safety testing under real-world conditions very difficult. Despite ongoing investment in safety research, the lack of validated test methods and different methods yielding diverse results allows scientific uncertainty to persist.

With regard to the first problem, the assumption that if a material at the macroscale is safe, then the same is true at the nanoscale informs regulation in Canada and, as far as I’m aware, every other constituency that has any type of nanomaterial regulation. I’ve had mixed feelings about this. On the one hand, we haven’t seen any serious problems associated with the use of nanomaterials but on the other hand, these problems can be slow to emerge.

The second issue mentioned, the lack of a consistent definition internationally, seems to be a relatively common problem in a lot of areas. As far as I’m aware, there aren’t that many international agreements for safety measures. Nuclear weapons and endangered animals and plants (CITES) being two of the few that come to mind.

The lack of protocols for safety testing of nanomaterials mentioned in the last paragraph of the excerpt is of rising concern. For example, there’s my July 7, 2015 posting featuring two efforts: Nanotechnology research protocols for Environment, Health and Safety Studies in US and a nanomedicine characterization laboratory in the European Union. Despite this and other efforts, I do think more can and should be done to standardize tests and protocols (without killing new types of research and results which don’t fit the models).

The authors do seem to be presenting a circular argument with this (from their Aug. 24, 2015 article; Note: A link has been removed),

Indeed, scientific uncertainty about nanomaterials’ risk profiles is a key barrier to their reliable assessment. A review funded by the European Commission concluded that:

[…] there is still insufficient data available to conduct the in depth risk assessments required to inform the regulatory decision making process on the safety of NMs [nanomaterials].

Reliable assessment of any chemical or drug is a major problem. We do have some good risk profiles but how many times have pharmaceutical companies developed a drug that passed successfully through human clinical trials only to present a serious risk when released to the general population? Assessing risk is a very complex problem. even with risk profiles and extensive testing.

Unmentioned throughout the article are naturally occurring nanoparticles (nanomaterials) and those created inadvertently through some manufacturing or other process. In fact, we have been ingesting nanomaterials throughout time. That said, I do agree we need to carefully consider the impact that engineered nanomaterials could have on us and the environment as ever more are being added.

To that end, the authors make some suggestions (Note: Links have been removed),

There are well-developed alternate decision-aiding tools available. One is multicriteria mapping, which seeks to evaluate various perspectives on an issue. Another is problem formulation and options assessment, which expands science-based risk assessment to engage a broader range of individuals and perspectives.

There is also pedigree assessment, which explores the framing and choices taking place at each step of an assessment process so as to better understand the ambiguity of scientific inputs into political processes.

Another, though less well developed, approach popular in Europe involves a shift from risk to innovation governance, with emphasis on developing “responsible research and innovation”.

I have some hesitation about recommending this read due to Georgia Miller’s involvement and the fact that I don’t have the time to check all the references. Miller was a spokesperson for Friends of the Earth (FoE) Australia, a group which led a substantive campaign against ‘nanosunscreens’. Here’s a July 20, 2010 posting where I featured some cherrypicking/misrepresentation of data by FoE in the persons of Georgia Miller and Ian Illuminato.

My Feb. 9, 2012 posting highlights the unintended consequences (avoidance of all sunscreens by some participants in a survey) of the FoE’s campaign in Australia (Note [1]: The percentage of people likely to avoid all sunscreens due to their concerns with nanoparticles in their sunscreens was originally reported to be 17%; Note [2]: Australia has the highest incidence of skin cancer in the world),

Feb.21.12 correction: According to the information in the Feb. 20, 2012 posting on 2020 Science, the percentage of Australians likely to avoid using sunscreens is 13%,

This has just landed in my email in box from Craig Cormick at the Department of Industry, Innovation, Science, Research and Tertiary Education in Australia, and I thought I would pass it on given the string of posts on nanoparticles in sunscreens on 2020 Science over the past few years:

“An online poll of 1,000 people, conducted in January this year, shows that one in three Australians had heard or read stories about the risks of using sunscreens with nanoparticles in them,” Dr Cormick said.

“Thirteen percent of this group were concerned or confused enough that they would be less likely to use any sunscreen, whether or not it contained nanoparticles, putting them selves at increased risk of developing potentially deadly skin cancers.

“The study also found that while one in five respondents stated they would go out of their way to avoid using sunscreens with nanoparticles in them, over three in five would need to know more information before deciding.”

This article with Fern Wickson (with whom I don’t always agree perfectly but hasn’t played any games with research that I’m know of) helps somewhat but it’s going to take more than this before I feel comfortable recommending Ms. Miller’s work for further reading.

Cosmetics giant, L’Oréal, to 3D print skin

L’Oréal, according to a May 19, 2015 BBC (British Broadcasting Corporation) online news item, has partnered with Organovo, a 3D bioprinting startup, to begin producing skin,

French cosmetics firm L’Oreal is teaming up with bio-engineering start-up Organovo to 3D-print human skin.

It said the printed skin would be used in product tests.

Organovo has already made headlines with claims that it can 3D-print a human liver but this is its first tie-up with the cosmetics industry.

Experts said the science might be legitimate but questioned why a beauty firm would want to print skin. [emphasis mine]

L’Oreal currently grows skin samples from tissues donated by plastic surgery patients. It produces more than 100,000, 0.5 sq cm skin samples per year and grows nine varieties across all ages and ethnicities.

Its statement explaining the advantage of printing skin, offered little detail: “Our partnership will not only bring about new advanced in vitro methods for evaluating product safety and performance, but the potential for where this new field of technology and research can take us is boundless.”

The beauty and cosmetics industry has a major interest in technology, especially anything to do with the skin. I’m curious as to what kind of an expert wouldn’t realize that cosmetics companies test products on skin and might like to have a ready supply. Still, I have to admit to surprise when I first (2006) started researching nanotechnology;  L’Oréal at one point was the sixth largest nanotechnology patent holder in the US (see my Nanotech Mysteries Wiki page: Marketers put the buy in nano [scroll down to Penetration subhead]). In 2008 L’Oréal company representatives were set for a discussion on their nanotechnology efforts and the precautionary principle, which was to be hosted by the Wilson Center’s Project for Emerging Nanotechnologies (PEN). The company cancelled at a rather interesting time as I had noted in my June 19, 2008 posting. (scroll down about 40% of the way until you see mention of Dr. Andrew Maynard).

Back to 3D printing technology and cosmetics giants, a May 5, 2015 Organovo/L’Oréal press release provides more detail about the deal,

L’Oreal USA, the largest subsidiary of the world’s leading beauty company, has announced a partnership with 3-D bioprinting company Organovo Holdings, Inc. (NYSE MKT: ONVO) (“Organovo”).  Developed between L’Oreal’s U.S.-based global Technology Incubator and Organovo, the collaboration will leverage Organovo’s proprietary NovoGen Bioprinting Platform and L’Oreal’s expertise in skin engineering to develop 3-D printed skin tissue for product evaluation and other areas of advanced research.

This partnership marks the first-ever application of Organovo’s groundbreaking technology within the beauty industry.

“We developed our technology incubator to uncover disruptive innovations across industries that have the potential to transform the beauty business,” said Guive Balooch, Global Vice President of L’Oreal’s Technology Incubator.  “Organovo has broken new ground with 3-D bioprinting, an area that complements L’Oreal’s pioneering work in the research and application of reconstructed skin for the past 30 years. Our partnership will not only bring about new advanced in vitro methods for evaluating product safety and performance, but the potential for where this new field of technology and research can take us is boundless.”

Organovo’s 3D bioprinting enables the reproducible, automated creation of living human tissues that mimic the form and function of native tissues in the body.

“We are excited to be partnering with L’Oreal, whose leadership in the beauty industry is rooted in scientific innovation and a deep commitment to research and development,” said Keith Murphy, Chairman and Chief Executive Officer at Organovo. “This partnership is a great next step to expand the applications of Organovo’s 3-D bioprinting technology and to create value for both L’Oreal and Organovo by building new breakthroughs in skin modeling.”

I don’t have much information about Organovo here, certainly nothing about the supposed liver (how did I miss that?), but there is a Dec. 26, 2012 posting about its deal with software giant, Autodesk.

Quantum dots, televisions, and a counter-intuitive approach to environmental issues

There’s a very interesting Jan. 8, 2015 essay by Dr. Andrew Maynard, being hosted on Nanowerk, about the effects that quantum dot televisions could have on the environment (Note: A link has been removed),

Earlier this week, The Conversation reported that, “The future is bright, the future is … quantum dot televisions”. And judging by the buzz coming from this week’s annual Consumer Electronics Show (CES) that’s right – the technology is providing manufacturers with a cheap and efficient way of producing the next generation of brilliant, high-definition TV screens.

But the quantum dots in these displays also use materials and technologies – including engineered nanoparticles and the heavy metal cadmium – that have been a magnet for health and environmental concerns. Will the dazzling pictures this technology allow blind us to new health and environmental challenges, or do their benefits outweigh the potential risks?

If I understand things rightly, cadmium is toxic at both the macroscale and the nanoscale and Andrew goes on to describe quantum dots (cadmium at the nanoscale) and the problem they could present in his Jan. 7, 2015 essay on The Conversation,also hosted by Nanowerk, (Note: Link have been removed),

Quantum dots are a product of the emerging field of nanotechnology. They are made of nanometer-sized particles of a semiconducting material – often cadmium selenide. About 2,000 to 20,000 times smaller than the width of a single human hair, they’re designed to absorb light of one color and emit it as another color – to fluoresce. This property makes them particularly well-suited for use in products like tablets and TVs that need bright, white, uniform backlights.

… What is unique about quantum dots is that the color of the emitted light can be modified by simply changing the size of the quantum dot particles. And because this color-shifting is a physical phenomenon, quantum dots far outperform their chemical counterparts in brightness, color and durability.

Unfortunately, the heavy metal cadmium used in the production of many quantum dots is a health and environmental hazard.

On top of this, the potential health and environmental impacts of engineered nanoparticles like quantum dots have been raising concerns with toxicologists and regulators for over a decade now. Research has shown that the size, shape and surface properties of some particles influence the harm they are capable of causing in humans and the environment; smaller particles are often more toxic than their larger counterparts. That said, this is an area where scientific understanding is still developing.

Together, these factors would suggest caution is warranted in adopting quantum dot technologies. Yet taken in isolation they are misleading.

The essay describes the risk factors for various sectors (Note: A link has been removed),

The quantum dots currently being used in TVs are firmly embedded in the screens – usually enclosed behind multiple layers of glass and plastic. As a result, the chances of users being exposed to them during normal operation are pretty much nil.

The situation is potentially different during manufacturing, when there is a chance that someone could be inadvertently exposed to these nanoscopic particles. Scenarios like this have led to agencies like the US National Institute for Occupational Safety and Health taking a close look at safety when working with nanoparticles. While the potential risks are not negligible, good working practices are effective at reducing or eliminating potentially harmful exposures.

End-of-life disposal raises additional concerns. While the nanoparticles are likely to remain firmly embedded within a trashed TV’s screen, the toxic materials they contain, including cadmium, could well be released into the environment. Cadmium is certainly a health and environmental issue with poorly regulated e-waste disposal and recycling. However, when appropriate procedures are used, exposures should be negligible.

It seems quantum dot televisions impose a smaller burden than their cousins on the environment,

Although it seems counter-intuitive, analysis by the company that was made available to the EPA [US Environmental Protection Agency] showed QD Vision’s products lead to a net decrease in environmental cadmium releases compared to conventional TVs. Cadmium is one of the pollutants emitted from coal-fired electrical power plants. Because TVs using the company’s quantum dots use substantially less power than their non-quantum counterparts, the combined cadmium in QD Vision TVs and the power plant emissions associated with their use is actually lower than that associated with conventional flat screen TVs. In other words, using cadmium in quantum dots for production of more energy-efficient displays can actually results in a net reduction in cadmium emissions.

Not the conclusion one might have drawn at the outset, eh? You can read the essay in its entirety on either Nanowerk (Jan. 8, 2015 essay) or The Conversation (Jan. 7, 2015 essay). (Same essay just different publication dates.) Andrew has also posted his essay on the University of Michigan Risk Science Center website, Are quantum dot TVs – and their toxic ingredients – actually better for the environment? Note: Andrew Maynard is the center’s director.

FrogHeart and 2014: acknowledging active colleagues and saying good-bye to defunct blogs and hello to the new

It’s been quite the year. In Feb. 2014, TED offered me free livestreaming of the event in Vancouver. In March/April 2014, Google tweaked its search function and sometime in September 2014 I decided to publish two pieces per day rather than three with the consequence that the visit numbers for this blog are lower than they might otherwise have been. More about statistics and traffic to this blog will be in the post I usually publish just the new year has started.

On other fronts, I taught two courses (Bioelectronics and Nanotechnology, the next big idea) this year for Simon Fraser University (Vancouver, Canada) in its Continuing Studies (aka Lifelong Learning) programmes. I also attended a World Congress on Alternatives to Animal Testing in the Life Sciences in Prague. The trip, sponsored by SEURAT-1 (Safety Evaluation Ultimately Replacing Animal Testing), will result in a total of five stories, the first having been recently (Dec. 26, 2014) published. I’m currently preparing a submission for the International Symposium on Electronic Arts being held in Vancouver in August 2015 based on a project I have embarked upon, ‘Steep’. Focused on gold nanoparticles, the project is Raewyn Turner‘s (an artist from New Zealand) brainchild. She has kindly opened up the project in such a way that I too can contribute. There are two other members of the Steep project, Brian Harris, an electrical designer, who works closely with Raewyn on a number of arts projects and there’s Mark Wiesner as our science consultant. Wiesner is a professor of civil and environmental engineering,at Duke University in North Carolina.

There is one other thing which you may have noticed, I placed a ‘Donate’ button on the blog early in 2014.

Acknowledgements, good-byes, and hellos

Dexter Johnson on his Nanoclast blog (on the IEEE [Institute of Electrical and Electronics Engineers] website) remains a constant in the nano sector of the blogosphere where he provides his incisive opinions and context for the nano scene.

David Bruggeman on his Pasco Phronesis blog offers valuable insight into the US science policy scene along with a lively calendar of art/science events and an accounting of the science and technology guests on late night US television.

Andrew Maynard archived his 2020 Science blog in July 2014 but he does continue writing and communication science as director of the University of Michigan Risk Science Center. Notably, Andrew continues to write, along with other contributors, on the Risk Without Borders blog at the University of Michigan.

Sadly, Cientifica, a emerging technologies business consultancy, where Tim Harper published a number of valuable white papers, reports, and blog postings is no longer with us. Happily, Tim continues with an eponymous website where he blogs and communicates about various business interests, “I’m currently involved in graphene, nanotechnology, construction, heating, and biosensing, working for a UK public company, as well as organisations ranging from MIT [Massachusetts Institute of Technology] to the World Economic Forum.” Glad to you’re back to blogging Tim. I missed your business savvy approach and occasional cheekiness!

I was delighted to learn of a new nano blog, NanoScéal, this year and relieved to see they’re hanging in. Their approach is curatorial where they present a week of selected nano stories. I don’t think a lot of people realize how much work a curatorial approach requires. Bravo!

Sir Martyn Poliakoff and the Periodic Table of Videos

Just as I was wondering what happened to the Periodic Table of Videos (my April 25, 2011 post offers a description of the project) Grrl Scientist on the Guardian science blog network offers information about one of the moving forces behind the project, Martyn Poliakoff in a Dec. 31, 2014 post,

This morning [Dec. 31, 2014], I was most pleased to learn that Martyn Poliakoff, professor of chemistry at the University of Nottingham, was awarded a bachelor knighthood by the Queen. So pleased was I that I struggled out of bed (badly wrecked back), my teeth gritted, so I could share this news with you.

Now Professor Poliakoff — who now is more properly known as Professor SIR Martyn Poliakoff — was awarded one of the highest civilian honours in the land, and his continued online presence has played a significant role in this.

“I think it may be the first time that YouTube has been mentioned when somebody has got a knighthood, and so I feel really quite proud about that. And I also really want to thank you YouTube viewers who have made this possible through your enthusiasm for chemistry.”

As for the Periodic Table of Videos, the series continues past the 118 elements currently identified to a include discussions on molecules.

Science Borealis, the Canadian science blog aggregator, which I helped to organize (albeit desultorily), celebrated its first full year of operation. Congratulations to all those who worked to make this project such a success that it welcomed its 100th blog earlier this year. From a Sept. 24, 2014 news item on Yahoo (Note: Links have been removed),

This week the Science Borealis team celebrated the addition of the 100th blog to its roster of Canadian science blog sites! As was recently noted in the Council of Canadian Academies report on Science Culture, science blogging in Canada is a rapidly growing means of science communication. Our digital milestone is one of many initiatives that are bringing to fruition the vision of a rich Canadian online science communication community.

The honour of being syndicated as the 100th blog goes to Spider Bytes, by Catherine Scott, an MSc [Master of Science] student at Simon Fraser University in Burnaby, British Columbia. …

As always, it’s been a pleasure and privilege writing and publishing this blog. Thank you all for your support whether it comes in the form of reading it, commenting, tweeting,  subscribing, and/or deciding to publish your own blog. May you have a wonderful and rewarding 2015!

FOE, nano, and food: part one of three (an FOE report is published)

It seems the food and nano debate of Spring/Summer 2014 has died down, for a while at least. The first volley (from my perspective) was the May 2014 release of ‘Way too little: Our Government’s failure to regulate nanomaterials in food and agriculture’ by the Friends of the Earth (FOE) Australia. Here’s how the report is described in a May 22, 2014 news item on Nanowerk,

Friends of the Earth’s new report, Way too little (pdf), looks at the now widespread presence of nanomaterials in our food chain and how little Food Standards Australia New Zealand (FSANZ) is doing to ensure our safety.

You can find the following passage on p. 6 of FOE’s report ‘Way too little: Our Government’s failure to regulate nanomaterials in food and agriculture‘,

This report will examine the changes since our 2008 report including the development of new food, food contact and agricultural products. It will review the current literature relating to the potential environmental, health and safety impacts associated with nanotechnology and summarise the Australian regulatory responses to date.

This updated report uncovers the:

•accelerating rate of commercialisation and rapidly increasing number of commercial products containing nanomaterials in the food and agricultural sectors;

•lack of information regarding which nanomaterials have been released and the likely exposure of humans and natural systems to these materials;

•lack of basic steps to allow us to track nanomaterials that have been released, such as
labelling and a register of products containing nanomaterials;

•growing gap between the pace of commercialisation and environmental, health and safety assessments;

•increasingly large body of peer reviewed evidence that certain nanomaterials may cause harm to human health or the environment;

•failure of regulators to respond to the growingevidence of risks;

•lack of basic knowledge that is critical in order to fully analyse the particular environmental, health and safety issues associated with nanotechnology.

Six years ago, inaction was based on a perceived lack of data. Inaction is still the norm but that is no longer an excuse our Government can use. Scientists and scientific bodies such as the US National Research Council have given us more than enough evidence to justify a pro-active regulatory regime and a properly funded R&D program that will effectively target those areas of greatest environmental and health concern.

Unfortunately, our Federal Government seems unwilling to provide the levels of funding required for such work or to adopt appropriate regulation. The notion of precaution has been replaced with an attitude that it is the obligation of industry to determine whether their products are safe and regulators will only act when harm is shown. While France, Belgium and Denmark are implementing a mandatory register for nanomaterials and the EU’s is in the process of implementing a nano food labelling regime, Australian consumers remain in the dark.

This needs to change.

One of the issues with increased regulation and labeling is whether the benefits outweigh disadvantages such as the increased difficulty of getting needed foodstuffs to the marketplace and, of course, cost.

Tom Philpott in a May 28, 2014 article for Mother Jones magazine titled ‘Big Dairy Is Putting Microscopic Pieces of Metal in Your Food’ is a strong proponent for FOE’s position, albeit his geographic focus is the US and he seems most concerned with metallic nanoparticles (Note: Links have been removed),

Examples include Silk Original Soy Milk, Rice Dream Rice Drink, Hershey’s Bliss Dark Chocolate, and Kraft’s iconic American Cheese Singles, all of which now contain nano-size titanium dioxide*. As recently as 2008, only eight US food products were known to contain nanoparticles, according to a recent analysis [May 2014 report] from Friends of the Earth—a more than tenfold increase in just six years.

Philpott goes on to mention the US Food and Drug Administration’s (FDA) 2012 draft guidance on nanomaterials and food,

Back in 2012, the FDA released a draft, pending public comment, of a proposed new framework for bringing nano materials into food. The document reveals plenty of reason for concern. For example: “so-called nano-engineered food substances can have significantly altered bioavailability and may, therefore, raise new safety issues that have not been seen in their traditionally manufactured counterparts.” The report went on to note that “particle size, surface area, aggregation/agglomeration, or shape may impact absorption, distribution, metabolism and excretion (ADME) and potentially the safety of the nano-engineered food substance.”

What FDA is saying here is obvious: If nanoparticles didn’t behave differently, the industry wouldn’t be using them in the first place.

So what’s the remedy? Rather than require rigorous safety studies before companies can lace food with nanoparticles, the FDA’s policy draft proposes “nonbinding recommendations” for such research. Even that rather porous safety net doesn’t yet exist—the agency still hasn’t implemented the draft proposal it released more than two years ago.[emphasis mine]

June 27, 2014, the FDA issued a final ‘food and nanotechnology’ guidance document (more on that later).

In the meantime, Dr. Andrew Maynard (Director of the University of Michigan’s Risk Science Center) strongly countered Philpott’s Mother Jones article with his own article published both on The Conversation (June 3, 2014) and on Nanowerk (June 4, 2014),

Recently the American publication Mother Jones published an article on the dangers of food laced with tiny metal oxide particles. The article, however, is laced with errors and misinformation.

The source material for the article came from a report by the environmental organisation Friends of the Earth, an online database of nanotechnology-based consumer products and a peer-reviewed paper published in 2012. However, the analysis of the information is flawed.


Bad journalism

The inventory Philpott cites is the Project on Emerging Nanotechnologies Consumer Products Inventory, which I helped establish in 2006 as a way better understand the increasing number of consumer products that were using engineered nanomaterials. It provides a useful but only qualitative sense of what was being used where, and relies on intermittent web searches and other sources of intelligence. The inventory was never meant to be comprehensive or authoritative.

Briefly, Andrew’s argument is that the FOE report (Way too little) which claims a tenfold increase since 2008 of food products with added nano titanium dioxide (and which Philpotts uses to build his case) is erroneous. In 2006, the inventory was voluntary and there was no oversight. At that time, eight food products had been added to the list. In 2013, the inventory was revived (Oct. 28, 2013 posting) and new information added from a 2012 academic paper. The products from the 2012 paper may have predated the 2006 inventory products, or not. There is no way to tell. Andrew notes this in his measured way,

As someone who works on the risks and benefits of nanotechnology, I can see how errors in translation crept into this story. The 2012 paper was addressing a legitimate concern that little is know about how much titanium dioxide is in the processed food chain. The Consumer Products Inventory provides important and unique insights into nanoparticles being used in products. Friends of the Earth have every right to ask what is known about the potential risks in what we’re eating. And reporters like Philpott have a professional obligation to highlight issues of concern and interest to their readers.

The problem with exaggerated and inflated claims is that FOE proves itself to be an unreliable source and Philpott’s failure to investigate adequately puts his own credibility into question. How can you trust either FOE’s materials or Philpott’s articles? The easiest way to begin rebuilding credibility is to admit one’s mistakes. To date, I have not seen any such attempts from FOE or Philpott.

Coming next: a research initiative into the health effects of nano and food and a research paper on nano in commercial drinks both of which help illustrate why there are concerns and why there is a reluctance to move too quickly.

Part two (the problem with research)

Part three (final guidance)

Science…For Her!—a book for those of us who like our science to be funny

The book, Science…For Her!, written by Megan Amram, a comedy writer whose credits include the Kroll Show and Parks and Recreation (US television programmes, won’t be available until Nov. 4, 2014 but it can be pre-ordered at Barnes & Noble or Powell’s (I figure Amazon gets enough advertising and I want to help bookstores that have a bricks & mortar presence, as well as, an online presence).

Thanks to David Bruggeman and the April 23, 2014 posting on his Pasco Phronesis blog where I first learned of this upcoming book (Note: Links have been removed),

There’s another science mashup coming your way later this year.  It’s a textbook written by comedy writer (Parks and Recreation) Megan Amram.  Science…For Her! comes out November 4, and stands a chance of provoking the same kind of reaction as the initial video for the European Commission’s campaign – ‘Science, it’s a girl thing‘.

For anyone unfamiliar with the European Commission’s campaign, check out Olga Khazan’s June 22, 2012 Washington Post story (h/t David Bruggeman) which is a relatively kind comment in comparison to some of the other responses to the campaign some of which I chronicled in my July 6, 2012 posting about it.

Getting back to Science…For Her!, here’s a bit more about the book from an April 22, 2014 posting by Madeleine Davies for Jezebel,

Of the book, Amram writes:

Science…For Her! is a science textbook written by a lady (me) for other ladies (you, the Spice Girls, etc.) It has been demonstrated repeatedly throughout history: female brains aren’t biologically constructed to understand scientific concepts, and tiny female hands aren’t constructed to turn most textbooks’ large, extra-heavy covers.

Finally, a science textbook for us.

[downloaded from http://meganamram.tumblr.com/post/83522299626/science-for-her]

[downloaded from http://meganamram.tumblr.com/post/83522299626/science-for-her]

As David notes elsewhere in his April 23, 2014 posting, the cover has a very ‘Cosmo’ feel with titles such as ‘orgasms vs. organisms’ and ‘sexiest molecules’. The Barnes & Noble ‘Science…For Her Page!, offers more details,

Megan Amram, one of Forbes’ “30 Under 30 in Hollywood & Entertainment,” Rolling Stone’s “25 Funniest People on Twitter,” and a writer for NBC’s hit show Parks and Recreation, delivers a politically, scientifically, and anatomically incorrect “textbook” that will have women screaming with laughter, and men dying to know what the noise is about.

In the vein of faux expert books by John Hodgman and Amy Sedaris, Science…for Her! is ostensibly a book of science written by a denizen of women’s magazines. Comedy writer and Twitter sensation Megan Amram showcases her fiendish wit with a pitch-perfect attack on everything from those insanely perky tips for self-improvement to our bizarre shopaholic dating culture to the socially mandated pursuit of mind-blowing sex to the cringe-worthy secret codes of food and body issues.

Part hilarious farce, part biting gender commentary, Amram blends Cosmo and science to highlight absurdities with a machine-gun of laugh-inducing lines that leave nothing and no one unscathed. Subjects include: this Spring’s ten most glamorous ways to die; tips for hosting your own big bang; what religion is right for your body type; and the most pressing issue facing women today: kale!!!

I appreciate the humour and applaud Amram’s wit. I also feel it should be noted that there is some very good science writing to be found (occasionally) in women’s magazines (e.g. Tracy Picha’s article ‘The Future of Our Body’ in an August 2009 issue  of Flare magazine [mentioned in my July 24, 2009 posting featuring human enhancement technologies’). As well, Andrew Maynard, physicist and then chief science advisor for the Project on Emerging Nanotechnologies, now NSF (US National Science Foundation) International Chair of Environmental Health Sciences and Director, University of Michigan Risk Science Center, once commented that one of the best descriptions of nanotechnology that he’d ever read was in an issue of Elle magazine.