Tag Archives: Ari Laiho

Protein cages, viruses, and nanoparticles

The Dec. 19, 2012 news release on EurekAlert about a study published by researchers at Aalto University (Finland) describes a project where virus particles are combined with nanoparticles to create new metamaterials,

Scientists from Aalto University, Finland, have succeeded in organising virus particles, protein cages and nanoparticles into crystalline materials. These nanomaterials studied by the Finnish research group are important for applications in sensing, optics, electronics and drug delivery.

… biohybrid superlattices of nanoparticles and proteins would allow the best features of both particle types to be combined. They would comprise the versatility of synthetic nanoparticles and the highly controlled assembly properties of biomolecules.

The gold nanoparticles and viruses adopt a special kind of crystal structure. It does not correspond to any known atomic or molecular crystal structure and it has previously not been observed with nano-sized particles.

Virus particles – the old foes of mankind – can do much more than infect living organisms. Evolution has rendered them with the capability of highly controlled self-assembly properties. Ultimately, by utilising their building blocks we can bring multiple functions to hybrid materials that consist of both living and synthetic matter, Kostiainen [Mauri A. Kostiainen, postdoctoral researcher] trusts.

The article which has been published in Nature Nanotechnology is free,

Electrostatic assembly of binary nanoparticle superlattices using protein cages by Mauri A. Kostiainen, Panu Hiekkataipale, Ari Laiho, Vincent Lemieux, Jani Seitsonen, Janne Ruokolainen & Pierpaolo Ceci in Nature Nanotechnology (2012) doi:10.1038/nnano.2012.220  Published online 16 December 2012

There’s a video demonstrating the assembly,

From the YouTube page, here’s a description of what the video is demonstrating,

Aalto University-led research group shows that CCMV virus or ferritin protein cages can be used to guide the assembly of RNA molecules or iron oxide nanoparticles into three-dimensional binary superlattices. The lattices are formed through tuneable electrostatic interactions with charged gold nanoparticles.

Bravo and thank  you to  Kostiainen who seems to have written the news release and prepared all of the additional materials (image and video). There are university press offices that could take lessons from Kostiainen’s efforts to communicate about the work.