Tag Archives: Case Western Reserve University

Revival of dead pig brains raises moral questions about life and death

The line between life and death may not be what we thought it was according to some research that was reported in April 2019. Ed Wong’s April 17, 2019 article (behind a paywall) for The Atlantic was my first inkling about the life-death questions raised by some research performed at Yale University, (Note: Links have been removed)

The brain, supposedly, cannot long survive without blood. Within seconds, oxygen supplies deplete, electrical activity fades, and unconsciousness sets in. If blood flow is not restored, within minutes, neurons start to die in a rapid, irreversible, and ultimately fatal wave.

But maybe not? According to a team of scientists led by Nenad Sestan at Yale School of Medicine, this process might play out over a much longer time frame, and perhaps isn’t as inevitable or irreparable as commonly believed. Sestan and his colleagues showed this in dramatic fashion—by preserving and restoring signs of activity in the isolated brains of pigs that had been decapitated four hours earlier.

The team sourced 32 pig brains from a slaughterhouse, placed them in spherical chambers, and infused them with nutrients and protective chemicals, using pumps that mimicked the beats of a heart. This system, dubbed BrainEx, preserved the overall architecture of the brains, preventing them from degrading. It restored flow in their blood vessels, which once again became sensitive to dilating drugs. It stopped many neurons and other cells from dying, and reinstated their ability to consume sugar and oxygen. Some of these rescued neurons even started to fire. “Everything was surprising,” says Zvonimir Vrselja, who performed most of the experiments along with Stefano Daniele.

… “I don’t see anything in this report that should undermine confidence in brain death as a criterion of death,” says Winston Chiong, a neurologist at the University of California at San Francisco. The matter of when to declare someone dead has become more controversial since doctors began relying more heavily on neurological signs, starting around 1968, when the criteria for “brain death” were defined. But that diagnosis typically hinges on the loss of brainwide activity—a line that, at least for now, is still final and irreversible. After MIT Technology Review broke the news of Sestan’s work a year ago, he started receiving emails from people asking whether he could restore brain function to their loved ones. He very much cannot. BrainEx isn’t a resurrection chamber.

“It’s not going to result in human brain transplants,” adds Karen Rommelfanger, who directs Emory University’s neuroethics program. “And I don’t think this means that the singularity is coming, or that radical life extension is more possible than before.”

So why do the study? “There’s potential for using this method to develop innovative treatments for patients with strokes or other types of brain injuries, and there’s a real need for those kinds of treatments,” says L. Syd M Johnson, a neuroethicist at Michigan Technological University. The BrainEx method might not be able to fully revive hours-dead brains, but Yama Akbari, a critical-care neurologist at the University of California at Irvine, wonders whether it would be more successful if applied minutes after death. Alternatively, it could help to keep oxygen-starved brains alive and intact while patients wait to be treated. “It’s an important landmark study,” Akbari says.

Yong notes that the study still needs to be replicated in his article which also probes some of the ethical issues associated with the latest neuroscience research.

Nature published the Yale study,

Restoration of brain circulation and cellular functions hours post-mortem by Zvonimir Vrselja, Stefano G. Daniele, John Silbereis, Francesca Talpo, Yury M. Morozov, André M. M. Sousa, Brian S. Tanaka, Mario Skarica, Mihovil Pletikos, Navjot Kaur, Zhen W. Zhuang, Zhao Liu, Rafeed Alkawadri, Albert J. Sinusas, Stephen R. Latham, Stephen G. Waxman & Nenad Sestan. Nature 568, 336–343 (2019) DOI: https://doi.org/10.1038/s41586-019-1099-1 Published 17 April 2019 Issue Date 18 April 2019

This paper is behind a paywall.

Two neuroethicists had this to say (link to their commentary in Nature follows) as per an April 71, 2019 news release from Case Western Reserve University (also on EurekAlert), Note: Links have been removed,

The brain is more resilient than previously thought. In a groundbreaking experiment published in this week’s issue of Nature, neuroscientists created an artificial circulation system that successfully restored some functions and structures in donated pig brains–up to four hours after the pigs were butchered at a USDA food processing facility. Though there was no evidence of restored consciousness, brains from the pigs were without oxygen for hours, yet could still support key functions provided by the artificial system. The result challenges the notion that mammalian brains are fully and irreversibly damaged by a lack of oxygen.

“The assumptions have always been that after a couple minutes of anoxia, or no oxygen, the brain is ‘dead,'” says Stuart Youngner, MD, who co-authored a commentary accompanying the study with Insoo Hyun, PhD, both professors in the Department of Bioethics at Case Western Reserve University School of Medicine. “The system used by the researchers begs the question: How long should we try to save people?”

In the pig experiment, researchers used an artificial perfusate (a type of cell-free “artificial blood”), which helped brain cells maintain their structure and some functions. Resuscitative efforts in humans, like CPR, are also designed to get oxygen to the brain and stave off brain damage. After a period of time, if a person doesn’t respond to resuscitative efforts, emergency medical teams declare them dead.

The acceptable duration of resuscitative efforts is somewhat uncertain. “It varies by country, emergency medical team, and hospital,” Youngner said. Promising results from the pig experiment further muddy the waters about the when to stop life-saving efforts.

At some point, emergency teams must make a critical switch from trying to save a patient, to trying to save organs, said Youngner. “In Europe, when emergency teams stop resuscitation efforts, they declare a patient dead, and then restart the resuscitation effort to circulate blood to the organs so they can preserve them for transplantation.”

The switch can involve extreme means. In the commentary, Youngner and Hyun describe how some organ recovery teams use a balloon to physically cut off blood circulation to the brain after declaring a person dead, to prepare the organs for transplantation.

The pig experiment implies that sophisticated efforts to perfuse the brain might maintain brain cells. If technologies like those used in the pig experiment could be adapted for humans (a long way off, caution Youngner and Hyun), some people who, today, are typically declared legally dead after a catastrophic loss of oxygen could, tomorrow, become candidates for brain resuscitation, instead of organ donation.

Said Youngner, “As we get better at resuscitating the brain, we need to decide when are we going to save a patient, and when are we going to declare them dead–and save five or more who might benefit from an organ.”

Because brain resuscitation strategies are in their infancy and will surely trigger additional efforts, the scientific and ethics community needs to begin discussions now, says Hyun. “This study is likely to raise a lot of public concerns. We hoped to get ahead of the hype and offer an early, reasoned response to this scientific advance.”

Both Youngner and Hyun praise the experiment as a “major scientific advancement” that is overwhelmingly positive. It raises the tantalizing possibility that the grave risks of brain damage caused by a lack of oxygen could, in some cases, be reversible.
“Pig brains are similar in many ways to human brains, which makes this study so compelling,” Hyun said. “We urge policymakers to think proactively about what this line of research might mean for ongoing debates around organ donation and end of life care.”

Here’s a link to and a citation to the Nature commentary,

Pig experiment challenges assumptions around brain damage in people by Stuart Youngner and Insoo Hyun. Nature 568, 302-304 (2019) DOI: 10.1038/d41586-019-01169-8 April 17, 2019

This paper is open access.

I was hoping to find out more about BrainEx, but this April 17, 2019 US National Institute of Mental Health news release is all I’ve been able to find in my admittedly brief online search. The news release offers more celebration than technical detail.

Quick comment

Interestingly, there hasn’t been much of a furor over this work. Not yet.

Did artists lead the way in mathematics?

There is no way to definitively answer the question of whether artists have led the way in mathematics but the question does provide interesting fodder for an essay (h/t April 28, 2017 news item on phys.org) by Henry Adams, professor of Art History at Case Western Reserve University , in his April 28, 2017 essay for TheConversation.com,

Mathematics and art are generally viewed as very different disciplines – one devoted to abstract thought, the other to feeling. But sometimes the parallels between the two are uncanny.

From Islamic tiling to the chaotic patterns of Jackson Pollock, we can see remarkable similarities between art and the mathematical research that follows it. The two modes of thinking are not exactly the same, but, in interesting ways, often one seems to foreshadow the other.

Does art sometimes spur mathematical discovery? There’s no simple answer to this question, but in some instances it seems very likely.

Patterns in the Alhambra

Consider Islamic ornament, such as that found in the Alhambra in Granada, Spain.

In the 14th and 15th centuries, the Alhambra served as the palace and harem of the Berber monarchs. For many visitors, it’s a setting as close to paradise as anything on earth: a series of open courtyards with fountains, surrounded by arcades that provide shelter and shade. The ceilings are molded in elaborate geometric patterns that resemble stalactites. The crowning glory is the ornament in colorful tile on the surrounding walls, which dazzles the eye in a hypnotic way that’s strangely blissful. In a fashion akin to music, the patterns lift the onlooker into an almost out-of-body state, a sort of heavenly rapture.

It’s a triumph of art – and of mathematical reasoning. The ornament explores a branch of mathematics known as tiling, which seeks to fill a space completely with regular geometric patterns. Math shows that a flat surface can be regularly covered by symmetric shapes with three, four and six sides, but not with shapes of five sides.

It’s also possible to combine different shapes, using triangular, square and hexagonal tiles to fill a space completely. The Alhambra revels in elaborate combinations of this sort, which are hard to see as stable rather than in motion. They seem to spin before our eyes. They trigger our brain into action and, as we look, we arrange and rearrange their patterns in different configurations.

An emotional experience? Very much so. But what’s fascinating about such Islamic tilings is that the work of anonymous artists and craftsmen also displays a near-perfect mastery of mathematical logic. Mathematicians have identified 17 types of symmetry: bilateral symmetry, rotational symmetry and so forth. At least 16 appear in the tilework of the Alhambra, almost as if they were textbook diagrams.

The patterns are not merely beautiful, but mathematically rigorous as well. They explore the fundamental characteristics of symmetry in a surprisingly complete way. Mathematicians, however, did not come up with their analysis of the principles of symmetry until several centuries after the tiles of the Alhambra had been set in place.

Tiles at the Alhambra. Credit: Wikimedia Commons, CC BY-SA

Quasicrystalline tiles

Stunning as they are, the decorations of the Alhambra may have been surpassed by a masterpiece in Persia. There, in 1453, anonymous craftsmen at the Darbi-I Imam shrine in Isfahan discovered quasicrystalline patterns. These patterns have complex and mysterious mathematical properties that were not analyzed by mathematicians until the discovery of Penrose tilings in the 1970s.

Such patterns fill a space completely with regular shapes, but in a configuration which never repeats itself – indeed, is infinitely nonrepeated – although the mathematical constant known as the Golden Section occurs over and over again.

Daniel Schectman won the 2001 Nobel Prize [Schechtman was awarded the Nobel Prize for Chemistry in 2011 as per his Wikipedia entry] or the discovery of quasicrystals, which obey this law of organization. This breakthrough forced scientists to reconsider their conception of the very nature of matter.

In 2005, Harvard physicist Peter James Lu showed that it’s possible to generate such quasicrystalline patterns relatively easily using girih tiles. Girih tiles combine several pure geometric shapes into five patterns: a regular decagon, an irregular hexagon, a bow tie, a rhombus and a regular pentagon.

Whatever the method, it’s clear that the quasicrystalline patterns at Darbi-I Imam were created by craftsmen without advanced training in mathematics. It took several more centuries for mathematicians to analyze and articulate what they were doing. In other words, intuition preceded full understanding.

It’s a fascinating essay and, if you have the time and the interest, it’s definitely a worthwhile read (Henry’s April 28, 2017 essay ).

Solar-powered graphene skin for more feeling in your prosthetics

A March 23, 2017 news item on Nanowerk highlights research that could put feeling into a prosthetic limb,

A new way of harnessing the sun’s rays to power ‘synthetic skin’ could help to create advanced prosthetic limbs capable of returning the sense of touch to amputees.

Engineers from the University of Glasgow, who have previously developed an ‘electronic skin’ covering for prosthetic hands made from graphene, have found a way to use some of graphene’s remarkable physical properties to use energy from the sun to power the skin.

Graphene is a highly flexible form of graphite which, despite being just a single atom thick, is stronger than steel, electrically conductive, and transparent. It is graphene’s optical transparency, which allows around 98% of the light which strikes its surface to pass directly through it, which makes it ideal for gathering energy from the sun to generate power.

A March 23, 2017 University of Glasgow press release, which originated the news item, details more about the research,

Ravinder Dahiya

Dr Ravinder Dahiya

A new research paper, published today in the journal Advanced Functional Materials, describes how Dr Dahiya and colleagues from his Bendable Electronics and Sensing Technologies (BEST) group have integrated power-generating photovoltaic cells into their electronic skin for the first time.

Dr Dahiya, from the University of Glasgow’s School of Engineering, said: “Human skin is an incredibly complex system capable of detecting pressure, temperature and texture through an array of neural sensors which carry signals from the skin to the brain.

“My colleagues and I have already made significant steps in creating prosthetic prototypes which integrate synthetic skin and are capable of making very sensitive pressure measurements. Those measurements mean the prosthetic hand is capable of performing challenging tasks like properly gripping soft materials, which other prosthetics can struggle with. We are also using innovative 3D printing strategies to build more affordable sensitive prosthetic limbs, including the formation of a very active student club called ‘Helping Hands’.

“Skin capable of touch sensitivity also opens the possibility of creating robots capable of making better decisions about human safety. A robot working on a construction line, for example, is much less likely to accidentally injure a human if it can feel that a person has unexpectedly entered their area of movement and stop before an injury can occur.”

The new skin requires just 20 nanowatts of power per square centimetre, which is easily met even by the poorest-quality photovoltaic cells currently available on the market. And although currently energy generated by the skin’s photovoltaic cells cannot be stored, the team are already looking into ways to divert unused energy into batteries, allowing the energy to be used as and when it is required.

Dr Dahiya added: “The other next step for us is to further develop the power-generation technology which underpins this research and use it to power the motors which drive the prosthetic hand itself. This could allow the creation of an entirely energy-autonomous prosthetic limb.

“We’ve already made some encouraging progress in this direction and we’re looking forward to presenting those results soon. We are also exploring the possibility of building on these exciting results to develop wearable systems for affordable healthcare. In this direction, recently we also got small funds from Scottish Funding Council.”

For more information about this advance and others in the field of prosthetics you may want to check out Megan Scudellari’s March 30, 2017 article for the IEEE’s (Institute of Electrical and Electronics Engineers) Spectrum (Note: Links have been removed),

Cochlear implants can restore hearing to individuals with some types of hearing loss. Retinal implants are now on the market to restore sight to the blind. But there are no commercially available prosthetics that restore a sense of touch to those who have lost a limb.

Several products are in development, including this haptic system at Case Western Reserve University, which would enable upper-limb prosthetic users to, say, pluck a grape off a stem or pull a potato chip out of a bag. It sounds simple, but such tasks are virtually impossible without a sense of touch and pressure.

Now, a team at the University of Glasgow that previously developed a flexible ‘electronic skin’ capable of making sensitive pressure measurements, has figured out how to power their skin with sunlight. …

Here’s a link to and a citation for the paper,

Energy-Autonomous, Flexible, and Transparent Tactile Skin by Carlos García Núñez, William Taube Navaraj, Emre O. Polat and Ravinder Dahiya. Advanced Functional Materials DOI: 10.1002/adfm.201606287 Version of Record online: 22 MAR 2017

© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

This paper is behind a paywall.

Quadriplegic man reanimates a limb with implanted brain-recording and muscle-stimulating systems

It took me a few minutes to figure out why this item about a quadriplegic (also known as, tetraplegic) man is news. After all, I have a May 17, 2012 posting which features a video and information about a quadri(tetra)plegic woman who was drinking her first cup of coffee, independently, in many years. The difference is that she was using an external robotic arm and this man is using *his own arm*,

This Case Western Reserve University (CRWU) video accompanies a March 28, 2017 CRWU news release, (h/t ScienceDaily March 28, 2017 news item)

Bill Kochevar grabbed a mug of water, drew it to his lips and drank through the straw.

His motions were slow and deliberate, but then Kochevar hadn’t moved his right arm or hand for eight years.

And it took some practice to reach and grasp just by thinking about it.

Kochevar, who was paralyzed below his shoulders in a bicycling accident, is believed to be the first person with quadriplegia in the world to have arm and hand movements restored with the help of two temporarily implanted technologies.

A brain-computer interface with recording electrodes under his skull, and a functional electrical stimulation (FES) system* activating his arm and hand, reconnect his brain to paralyzed muscles.

Holding a makeshift handle pierced through a dry sponge, Kochevar scratched the side of his nose with the sponge. He scooped forkfuls of mashed potatoes from a bowl—perhaps his top goal—and savored each mouthful.

“For somebody who’s been injured eight years and couldn’t move, being able to move just that little bit is awesome to me,” said Kochevar, 56, of Cleveland. “It’s better than I thought it would be.”

Kochevar is the focal point of research led by Case Western Reserve University, the Cleveland Functional Electrical Stimulation (FES) Center at the Louis Stokes Cleveland VA Medical Center and University Hospitals Cleveland Medical Center (UH). A study of the work was published in the The Lancet March 28 [2017] at 6:30 p.m. U.S. Eastern time.

“He’s really breaking ground for the spinal cord injury community,” said Bob Kirsch, chair of Case Western Reserve’s Department of Biomedical Engineering, executive director of the FES Center and principal investigator (PI) and senior author of the research. “This is a major step toward restoring some independence.”

When asked, people with quadriplegia say their first priority is to scratch an itch, feed themselves or perform other simple functions with their arm and hand, instead of relying on caregivers.

“By taking the brain signals generated when Bill attempts to move, and using them to control the stimulation of his arm and hand, he was able to perform personal functions that were important to him,” said Bolu Ajiboye, assistant professor of biomedical engineering and lead study author.

Technology and training

The research with Kochevar is part of the ongoing BrainGate2* pilot clinical trial being conducted by a consortium of academic and VA institutions assessing the safety and feasibility of the implanted brain-computer interface (BCI) system in people with paralysis. Other investigational BrainGate research has shown that people with paralysis can control a cursor on a computer screen or a robotic arm (braingate.org).

“Every day, most of us take for granted that when we will to move, we can move any part of our body with precision and control in multiple directions and those with traumatic spinal cord injury or any other form of paralysis cannot,” said Benjamin Walter, associate professor of neurology at Case Western Reserve School of Medicine, clinical PI of the Cleveland BrainGate2 trial and medical director of the Deep Brain Stimulation Program at UH Cleveland Medical Center.

“The ultimate hope of any of these individuals is to restore this function,” Walter said. “By restoring the communication of the will to move from the brain directly to the body this work will hopefully begin to restore the hope of millions of paralyzed individuals that someday they will be able to move freely again.”

Jonathan Miller, assistant professor of neurosurgery at Case Western Reserve School of Medicine and director of the Functional and Restorative Neurosurgery Center at UH, led a team of surgeons who implanted two 96-channel electrode arrays—each about the size of a baby aspirin—in Kochevar’s motor cortex, on the surface of the brain.

The arrays record brain signals created when Kochevar imagines movement of his own arm and hand. The brain-computer interface extracts information from the brain signals about what movements he intends to make, then passes the information to command the electrical stimulation system.

To prepare him to use his arm again, Kochevar first learned how to use his brain signals to move a virtual-reality arm on a computer screen.

“He was able to do it within a few minutes,” Kirsch said. “The code was still in his brain.”

As Kochevar’s ability to move the virtual arm improved through four months of training, the researchers believed he would be capable of controlling his own arm and hand.

Miller then led a team that implanted the FES systems’ 36 electrodes that animate muscles in the upper and lower arm.

The BCI decodes the recorded brain signals into the intended movement command, which is then converted by the FES system into patterns of electrical pulses.

The pulses sent through the FES electrodes trigger the muscles controlling Kochevar’s hand, wrist, arm, elbow and shoulder. To overcome gravity that would otherwise prevent him from raising his arm and reaching, Kochevar uses a mobile arm support, which is also under his brain’s control.

New Capabilities

Eight years of muscle atrophy required rehabilitation. The researchers exercised Kochevar’s arm and hand with cyclical electrical stimulation patterns. Over 45 weeks, his strength, range of motion and endurance improved. As he practiced movements, the researchers adjusted stimulation patterns to further his abilities.

Kochevar can make each joint in his right arm move individually. Or, just by thinking about a task such as feeding himself or getting a drink, the muscles are activated in a coordinated fashion.

When asked to describe how he commanded the arm movements, Kochevar told investigators, “I’m making it move without having to really concentrate hard at it…I just think ‘out’…and it goes.”

Kocehvar is fitted with temporarily implanted FES technology that has a track record of reliable use in people. The BCI and FES system together represent early feasibility that gives the research team insights into the potential future benefit of the combined system.

Advances needed to make the combined technology usable outside of a lab are not far from reality, the researchers say. Work is underway to make the brain implant wireless, and the investigators are improving decoding and stimulation patterns needed to make movements more precise. Fully implantable FES systems have already been developed and are also being tested in separate clinical research.

Kochevar welcomes new technology—even if it requires more surgery—that will enable him to move better. “This won’t replace caregivers,” he said. “But, in the long term, people will be able, in a limited way, to do more for themselves.”

There is more about the research in a March 29, 2017 article by Sarah Boseley for The Guardian,

Bill Kochevar, 53, has had electrical implants in the motor cortex of his brain and sensors inserted in his forearm, which allow the muscles of his arm and hand to be stimulated in response to signals from his brain, decoded by computer. After eight years, he is able to drink and feed himself without assistance.

“I think about what I want to do and the system does it for me,” Kochevar told the Guardian. “It’s not a lot of thinking about it. When I want to do something, my brain does what it does.”

The experimental technology, pioneered by the Case Western Reserve University in Cleveland, Ohio, is the first in the world to restore brain-controlled reaching and grasping in a person with complete paralysis.

For now, the process is relatively slow, but the scientists behind the breakthrough say this is proof of concept and that they hope to streamline the technology until it becomes a routine treatment for people with paralysis. In the future, they say, it will also be wireless and the electrical arrays and sensors will all be implanted under the skin and invisible.

A March 28, 2017 Lancet news release on EurekAlert provides a little more technical insight into the research and Kochevar’s efforts,

Although only tested with one participant, the study is a major advance and the first to restore brain-controlled reaching and grasping in a person with complete paralysis. The technology, which is only for experimental use in the USA, circumvents rather than repairs spinal injuries, meaning the participant relies on the device being implanted and switched on to move.

“Our research is at an early stage, but we believe that this neuro-prosthesis could offer individuals with paralysis the possibility of regaining arm and hand functions to perform day-to-day activities, offering them greater independence,” said lead author Dr Bolu Ajiboye, Case Western Reserve University, USA. “So far it has helped a man with tetraplegia to reach and grasp, meaning he could feed himself and drink. With further development, we believe the technology could give more accurate control, allowing a wider range of actions, which could begin to transform the lives of people living with paralysis.” [1]

Previous research has used similar elements of the neuro-prosthesis. For example, a brain-computer interface linked to electrodes on the skin has helped a person with less severe paralysis open and close his hand, while other studies have allowed participants to control a robotic arm using their brain signals. However, this is the first to restore reaching and grasping via the system in a person with a chronic spinal cord injury.

In this study, a 53 year-old man who had been paralysed below the shoulders for eight years underwent surgery to have the neuro-prosthesis fitted.

This involved brain surgery to place sensors in the motor cortex area of his brain responsible for hand movement – creating a brain-computer interface that learnt which movements his brain signals were instructing for. This initial stage took four months and included training using a virtual reality arm.

He then underwent another procedure placing 36 muscle stimulating electrodes into his upper and lower arm, including four that helped restore finger and thumb, wrist, elbow and shoulder movements. These were switched on 17 days after the procedure, and began stimulating the muscles for eight hours a week over 18 weeks to improve strength, movement and reduce muscle fatigue.

The researchers then wired the brain-computer interface to the electrical stimulators in his arm, using a decoder (mathematical algorithm) to translate his brain signals into commands for the electrodes in his arm. The electrodes stimulated the muscles to produce contractions, helping the participant intuitively complete the movements he was thinking of. The system also involved an arm support to stop gravity simply pulling his arm down.

During his training, the participant described how he controlled the neuro-prosthesis: “It’s probably a good thing that I’m making it move without having to really concentrate hard at it. I just think ‘out’ and it just goes.”

After 12 months of having the neuro-prosthesis fitted, the participant was asked to complete day-to-day tasks, including drinking a cup of coffee and feeding himself. First of all, he observed while his arm completed the action under computer control. During this, he thought about making the same movement so that the system could recognise the corresponding brain signals. The two systems were then linked and he was able to use it to drink a coffee and feed himself.

He successfully drank in 11 out of 12 attempts, and it took him roughly 20-40 seconds to complete the task. When feeding himself, he did so multiple times – scooping forkfuls of food and navigating his hand to his mouth to take several bites.

“Although similar systems have been used before, none of them have been as easy to adopt for day-to-day use and they have not been able to restore both reaching and grasping actions,” said Dr Ajiboye. “Our system builds on muscle stimulating electrode technology that is already available and will continue to improve with the development of new fully implanted and wireless brain-computer interface systems. This could lead to enhanced performance of the neuro-prosthesis with better speed, precision and control.” [1]

At the time of the study, the participant had had the neuro-prosthesis implanted for almost two years (717 days) and in this time experienced four minor, non-serious adverse events which were treated and resolved.

Despite its achievements, the neuro-prosthesis still had some limitations, including that movements made using it were slower and less accurate than those made using the virtual reality arm the participant used for training. When using the technology, the participant also needed to watch his arm as he lost his sense of proprioception – the ability to intuitively sense the position and movement of limbs – as a result of the paralysis.

Writing in a linked Comment, Dr Steve Perlmutter, University of Washington, USA, said: “The goal is futuristic: a paralysed individual thinks about moving her arm as if her brain and muscles were not disconnected, and implanted technology seamlessly executes the desired movement… This study is groundbreaking as the first report of a person executing functional, multi-joint movements of a paralysed limb with a motor neuro-prosthesis. However, this treatment is not nearly ready for use outside the lab. The movements were rough and slow and required continuous visual feedback, as is the case for most available brain-machine interfaces, and had restricted range due to the use of a motorised device to assist shoulder movements… Thus, the study is a proof-of-principle demonstration of what is possible, rather than a fundamental advance in neuro-prosthetic concepts or technology. But it is an exciting demonstration nonetheless, and the future of motor neuro-prosthetics to overcome paralysis is brighter.”

[1] Quote direct from author and cannot be found in the text of the Article.

Here’s a link to and a citation for the paper,

Restoration of reaching and grasping movements through brain-controlled muscle stimulation in a person with tetraplegia: a proof-of-concept demonstration by A Bolu Ajiboye, Francis R Willett, Daniel R Young, William D Memberg, Brian A Murphy, Jonathan P Miller, Benjamin L Walter, Jennifer A Sweet, Harry A Hoyen, Michael W Keith, Prof P Hunter Peckham, John D Simeral, Prof John P Donoghue, Prof Leigh R Hochberg, Prof Robert F Kirsch. The Lancet DOI: http://dx.doi.org/10.1016/S0140-6736(17)30601-3 Published: 28 March 2017 [online?]

This paper is behind a paywall.

For anyone  who’s interested, you can find the BrainGate website here.

*I initially misidentified the nature of the achievement and stated that Kochevar used a “robotic arm, which is attached to his body” when it was his own reanimated arm. Corrected on April 25, 2017.

Robots built from living tissue

Biohybrid robots, as they are known, are built from living tissue but not in a Frankenstein kind of way as Victoria Webster PhD candidate at Case Western Reserve University (US) explains in her Aug. 9, 2016 essay on The Conversation (also on phys.org as an Aug. 10, 2016 news item; Note: Links have been removed),

Researchers are increasingly looking for solutions to make robots softer or more compliant – less like rigid machines, more like animals. With traditional actuators – such as motors – this can mean using air muscles or adding springs in parallel with motors. …

But there’s a growing area of research that’s taking a different approach. By combining robotics with tissue engineering, we’re starting to build robots powered by living muscle tissue or cells. These devices can be stimulated electrically or with light to make the cells contract to bend their skeletons, causing the robot to swim or crawl. The resulting biobots can move around and are soft like animals. They’re safer around people and typically less harmful to the environment they work in than a traditional robot might be. And since, like animals, they need nutrients to power their muscles, not batteries, biohybrid robots tend to be lighter too.

Webster explains how these biobots are built,

Researchers fabricate biobots by growing living cells, usually from heart or skeletal muscle of rats or chickens, on scaffolds that are nontoxic to the cells. If the substrate is a polymer, the device created is a biohybrid robot – a hybrid between natural and human-made materials.

If you just place cells on a molded skeleton without any guidance, they wind up in random orientations. That means when researchers apply electricity to make them move, the cells’ contraction forces will be applied in all directions, making the device inefficient at best.

So to better harness the cells’ power, researchers turn to micropatterning. We stamp or print microscale lines on the skeleton made of substances that the cells prefer to attach to. These lines guide the cells so that as they grow, they align along the printed pattern. With the cells all lined up, researchers can direct how their contraction force is applied to the substrate. So rather than just a mess of firing cells, they can all work in unison to move a leg or fin of the device.

Researchers sometimes mimic animals when creating their biobots (Note: Links have been removed),

Others have taken their cues from nature, creating biologically inspired biohybrids. For example, a group led by researchers at California Institute of Technology developed a biohybrid robot inspired by jellyfish. This device, which they call a medusoid, has arms arranged in a circle. Each arm is micropatterned with protein lines so that cells grow in patterns similar to the muscles in a living jellyfish. When the cells contract, the arms bend inwards, propelling the biohybrid robot forward in nutrient-rich liquid.

More recently, researchers have demonstrated how to steer their biohybrid creations. A group at Harvard used genetically modified heart cells to make a biologically inspired manta ray-shaped robot swim. The heart cells were altered to contract in response to specific frequencies of light – one side of the ray had cells that would respond to one frequency, the other side’s cells responded to another.

Amazing, eh? And, this is quite a recent video; it was published on YouTube on July 7, 2016.

Webster goes on to describe work designed to make these robots hardier and more durable so they can leave the laboratory,

… Here at Case Western Reserve University, we’ve recently begun to investigate … by turning to the hardy marine sea slug Aplysia californica. Since A. californica lives in the intertidal region, it can experience big changes in temperature and environmental salinity over the course of a day. When the tide goes out, the sea slugs can get trapped in tide pools. As the sun beats down, water can evaporate and the temperature will rise. Conversely in the event of rain, the saltiness of the surrounding water can decrease. When the tide eventually comes in, the sea slugs are freed from the tidal pools. Sea slugs have evolved very hardy cells to endure this changeable habitat.

We’ve been able to use Aplysia tissue to actuate a biohybrid robot, suggesting that we can manufacture tougher biobots using these resilient tissues. The devices are large enough to carry a small payload – approximately 1.5 inches long and one inch wide.

Webster has written a fascinating piece and, if you have time, I encourage you to read it in its entirety.

Wearable tech for Christmas 2015 and into 2016

This is a roundup post of four items to cross my path this morning (Dec. 17, 2015), all of them concerned with wearable technology.

The first, a Dec. 16, 2015 news item on phys.org, is a fluffy little piece concerning the imminent arrival of a new generation of wearable technology,

It’s not every day that there’s a news story about socks. But in November [2015], a pair won the Best New Wearable Technology Device Award at a Silicon Valley conference. The smart socks, which track foot landings and cadence, are at the forefront of a new generation of wearable electronics, according to an article in Chemical & Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society [ACS].

That news item was originated by a Dec. 16, 2015 ACS news release on EurekAlert which adds this,

Marc S. Reisch, a senior correspondent at C&EN, notes that stiff wristbands like the popular FitBit that measure heart rate and the number of steps people take have become common. But the long-touted technology needed to create more flexible monitoring devices has finally reached the market. Developers have successfully figured out how to incorporate stretchable wiring and conductive inks in clothing fabric, program them to transmit data wirelessly and withstand washing.

In addition to smart socks, fitness shirts and shoe insoles are on the market already or are nearly there. Although athletes are among the first to gain from the technology, the less fitness-oriented among us could also benefit. One fabric concept product — designed not for covering humans but a car steering-wheel — could sense driver alertness and make roads safer.

Reisch’s Dec. 7, 2015 article (C&EN vol. 93, issue 48, pp. 28-90) provides more detailed information and market information such as this,

Materials suppliers, component makers, and apparel developers gathered at a printed-electronics conference in Santa Clara, Calif., within a short drive of tech giants such as Google and Apple, to compare notes on embedding electronics into the routines of daily life. A notable theme was the effort to stealthily [emphasis mine] place sensors on exercise shirts, socks, and shoe soles so that athletes and fitness buffs can wirelessly track their workouts and doctors can monitor the health of their patients.

“Wearable technology is becoming more wearable,” said Raghu Das, chief executive officer of IDTechEx [emphasis mine], the consulting firm that organized the conference. By that he meant the trend is toward thinner and more flexible devices that include not just wrist-worn fitness bands but also textiles printed with stretchable wiring and electronic sensors, thanks to advances in conductive inks.

Interesting use of the word ‘stealthy’, which often suggests something sneaky as opposed to merely secretive. I imagine what’s being suggested is that the technology will not impose itself on the user (i.e., you won’t have to learn how to use it as you did with phones and computers).

Leading into my second item, IDC (International Data Corporation), not to be confused with IDTechEx, is mentioned in a Dec. 17, 2015 news item about wearable technology markets on phys.org,

The global market for wearable technology is seeing a surge, led by watches, smart clothing and other connected gadgets, a research report said Thursday [Dec. 16, 2015].

IDC said its forecast showed the worldwide wearable device market will reach a total of 111.1 million units in 2016, up 44.4 percent from this year.

By 2019, IDC sees some 214.6 million units, or a growth rate averaging 28 percent.

A Dec. 17, 2015 IDC press release, which originated the news item, provides more details about the market forecast,

“The most common type of wearables today are fairly basic, like fitness trackers, but over the next few years we expect a proliferation of form factors and device types,” said Jitesh Ubrani , Senior Research Analyst for IDC Mobile Device Trackers. “Smarter clothing, eyewear, and even hearables (ear-worn devices) are all in their early stages of mass adoption. Though at present these may not be significantly smarter than their analog counterparts, the next generation of wearables are on track to offer vastly improved experiences and perhaps even augment human abilities.”

One of the most popular types of wearables will be smartwatches, reaching a total of 34.3 million units shipped in 2016, up from the 21.3 million units expected to ship in 2015. By 2019, the final year of the forecast, total shipments will reach 88.3 million units, resulting in a five-year CAGR of 42.8%.

“In a short amount of time, smartwatches have evolved from being extensions of the smartphone to wearable computers capable of communications, notifications, applications, and numerous other functionalities,” noted Ramon Llamas , Research Manager for IDC’s Wearables team. “The smartwatch we have today will look nothing like the smartwatch we will see in the future. Cellular connectivity, health sensors, not to mention the explosive third-party application market all stand to change the game and will raise both the appeal and value of the market going forward.

“Smartwatch platforms will lead the evolution,” added Llamas. “As the brains of the smartwatch, platforms manage all the tasks and processes, not the least of which are interacting with the user, running all of the applications, and connecting with the smartphone. Once that third element is replaced with cellular connectivity, the first two elements will take on greater roles to make sense of all the data and connections.”

Top Five Smartwatch Platform Highlights

Apple’s watchOS will lead the smartwatch market throughout our forecast, with a loyal fanbase of Apple product owners and a rapidly growing application selection, including both native apps and Watch-designed apps. Very quickly, watchOS has become the measuring stick against which other smartwatches and platforms are compared. While there is much room for improvement and additional features, there is enough momentum to keep it ahead of the rest of the market.

Android/Android Wear will be a distant second behind watchOS even as its vendor list grows to include technology companies (ASUS, Huawei, LG, Motorola, and Sony) and traditional watchmakers (Fossil and Tag Heuer). The user experience on Android Wear devices has been largely the same from one device to the next, leaving little room for OEMs to develop further and users left to select solely on price and smartwatch design.

Smartwatch pioneer Pebble will cede market share to AndroidWear and watchOS but will not disappear altogether. Its simple user interface and devices make for an easy-to-understand use case, and its price point relative to other platforms makes Pebble one of the most affordable smartwatches on the market.

Samsung’s Tizen stands to be the dark horse of the smartwatch market and poses a threat to Android Wear, including compatibility with most flagship Android smartphones and an application selection rivaling Android Wear. Moreover, with Samsung, Tizen has benefited from technology developments including a QWERTY keyboard on a smartwatch screen, cellular connectivity, and new user interfaces. It’s a combination that helps Tizen stand out, but not enough to keep up with AndroidWear and watchOS.

There will be a small, but nonetheless significant market for smart wristwear running on a Real-Time Operating System (RTOS), which is capable of running third-party applications, but not on any of these listed platforms. These tend to be proprietary operating systems and OEMs will use them when they want to champion their own devices. These will help within specific markets or devices, but will not overtake the majority of the market.

The company has provided a table with five-year CAGR (compound annual growth rate) growth estimates, which can be found with the Dec. 17, 2015 IDC press release.

Disclaimer: I am not endorsing IDC’s claims regarding the market for wearable technology.

For the third and fourth items, it’s back to the science. A Dec. 17, 2015 news item on Nanowerk, describes, in general terms, some recent wearable technology research at the University of Manchester (UK), Note: A link has been removed),

Cheap, flexible, wireless graphene communication devices such as mobile phones and healthcare monitors can be directly printed into clothing and even skin, University of Manchester academics have demonstrated.

In a breakthrough paper in Scientific Reports (“Highly Flexible and Conductive Printed Graphene for Wireless Wearable Communications Applications”), the researchers show how graphene could be crucial to wearable electronic applications because it is highly-conductive and ultra-flexible.

The research could pave the way for smart, battery-free healthcare and fitness monitoring, phones, internet-ready devices and chargers to be incorporated into clothing and ‘smart skin’ applications – printed graphene sensors integrated with other 2D materials stuck onto a patient’s skin to monitor temperature, strain and moisture levels.

Detail is provided in a Dec. 17, 2015 University of Manchester press release, which originated the news item, (Note: Links have been removed),

Examples of communication devices include:

• In a hospital, a patient wears a printed graphene RFID tag on his or her arm. The tag, integrated with other 2D materials, can sense the patient’s body temperature and heartbeat and sends them back to the reader. The medical staff can monitor the patient’s conditions wirelessly, greatly simplifying the patient’s care.

• In a care home, battery-free printed graphene sensors can be printed on elderly peoples’ clothes. These sensors could detect and collect elderly people’s health conditions and send them back to the monitoring access points when they are interrogated, enabling remote healthcare and improving quality of life.

Existing materials used in wearable devices are either too expensive, such as silver nanoparticles, or not adequately conductive to have an effect, such as conductive polymers.

Graphene, the world’s thinnest, strongest and most conductive material, is perfect for the wearables market because of its broad range of superlative qualities. Graphene conductive ink can be cheaply mass produced and printed onto various materials, including clothing and paper.

“Sir Kostya Novoselov

To see evidence that cheap, scalable wearable communication devices are on the horizon is excellent news for graphene commercial applications.

Sir Kostya Novoselov (tweet)„

The researchers, led by Dr Zhirun Hu, printed graphene to construct transmission lines and antennas and experimented with these in communication devices, such as mobile and Wifi connectivity.

Using a mannequin, they attached graphene-enabled antennas on each arm. The devices were able to ‘talk’ to each other, effectively creating an on-body communications system.

The results proved that graphene enabled components have the required quality and functionality for wireless wearable devices.

Dr Hu, from the School of Electrical and Electronic Engineering, said: “This is a significant step forward – we can expect to see a truly all graphene enabled wireless wearable communications system in the near future.

“The potential applications for this research are huge – whether it be for health monitoring, mobile communications or applications attached to skin for monitoring or messaging.

“This work demonstrates that this revolutionary scientific material is bringing a real change into our daily lives.”

Co-author Sir Kostya Novoselov, who with his colleague Sir Andre Geim first isolated graphene at the University in 2004, added: “Research into graphene has thrown up significant potential applications, but to see evidence that cheap, scalable wearable communication devices are on the horizon is excellent news for graphene commercial applications.”

Here’s a link to and a citation for the paper,

Highly Flexible and Conductive Printed Graphene for Wireless Wearable Communications Applications by Xianjun Huang, Ting Leng, Mengjian Zhu, Xiao Zhang, JiaCing Chen, KuoHsin Chang, Mohammed Aqeeli, Andre K. Geim, Kostya S. Novoselov, & Zhirun Hu. Scientific Reports 5, Article number: 18298 (2015) doi:10.1038/srep18298 Published online: 17 December 2015

This is an open access paper.

The next and final item concerns supercapacitors for wearable tech, which makes it slightly different from the other items and is why, despite the date, this is the final item. The research comes from Case Western Research University (CWRU; US) according to a Dec. 16, 2015 news item on Nanowerk (Note: A link has been removed),

Wearable power sources for wearable electronics are limited by the size of garments.

With that in mind, researchers at Case Western Reserve University have developed flexible wire-shaped microsupercapacitors that can be woven into a jacket, shirt or dress (Energy Storage Materials, “Flexible and wearable wire-shaped microsupercapacitors based on highly aligned titania and carbon nanotubes”).

A Dec. 16, 2015 CWRU news release (on EurekAlert), which originated the news item, provides more detail about a device that would make wearable tech more wearable (after all, you don’t want to recharge your clothes the same way you do your phone and other mobile devices),

By their design or by connecting the capacitors in series or parallel, the devices can be tailored to match the charge storage and delivery needs of electronics donned.

While there’s been progress in development of those electronics–body cameras, smart glasses, sensors that monitor health, activity trackers and more–one challenge remaining is providing less obtrusive and cumbersome power sources.

“The area of clothing is fixed, so to generate the power density needed in a small area, we grew radially-aligned titanium oxide nanotubes on a titanium wire used as the main electrode,” said Liming Dai, the Kent Hale Smith Professor of Macromolecular Science and Engineering. “By increasing the surface area of the electrode, you increase the capacitance.”

Dai and Tao Chen, a postdoctoral fellow in molecular science and engineering at Case Western Reserve, published their research on the microsupercapacitor in the journal Energy Storage Materials this week. The study builds on earlier carbon-based supercapacitors.

A capacitor is cousin to the battery, but offers the advantage of charging and releasing energy much faster.

How it works

In this new supercapacitor, the modified titanium wire is coated with a solid electrolyte made of polyvinyl alcohol and phosphoric acid. The wire is then wrapped with either yarn or a sheet made of aligned carbon nanotubes, which serves as the second electrode. The titanium oxide nanotubes, which are semiconducting, separate the two active portions of the electrodes, preventing a short circuit.

In testing, capacitance–the capability to store charge–increased from 0.57 to 0.9 to 1.04 milliFarads per micrometer as the strands of carbon nanotube yarn were increased from 1 to 2 to 3.

When wrapped with a sheet of carbon nanotubes, which increases the effective area of electrode, the microsupercapactitor stored 1.84 milliFarads per micrometer. Energy density was 0.16 x 10-3 milliwatt-hours per cubic centimeter and power density .01 milliwatt per cubic centimeter.

Whether wrapped with yarn or a sheet, the microsupercapacitor retained at least 80 percent of its capacitance after 1,000 charge-discharge cycles. To match various specific power needs of wearable devices, the wire-shaped capacitors can be connected in series or parallel to raise voltage or current, the researchers say.

When bent up to 180 degrees hundreds of times, the capacitors showed no loss of performance. Those wrapped in sheets showed more mechanical strength.

“They’re very flexible, so they can be integrated into fabric or textile materials,” Dai said. “They can be a wearable, flexible power source for wearable electronics and also for self-powered biosensors or other biomedical devices, particularly for applications inside the body.” [emphasis mine]

Dai ‘s lab is in the process of weaving the wire-like capacitors into fabric and integrating them with a wearable device.

So one day we may be carrying supercapacitors in our bodies? I’m not sure how I feel about that goal. In any event, here’s a link and a citation for the paper,

Flexible and wearable wire-shaped microsupercapacitors based on highly aligned titania and carbon nanotubes by Tao Chen, Liming Dai. Energy Storage Materials Volume 2, January 2016, Pages 21–26 doi:10.1016/j.ensm.2015.11.004

This paper appears to be open access.

Park Nano Academy: How Graphene–based Nanomaterials and Films Revolutionize Science webinar

There’s another Park Systems webinar coming up on July 9, 2015 (the last one concerning Nanostructured Polymers and Nanomaterials for Oil & Gas was mentioned  in my June 9, 2015 posting).

This latest webinar series is focused on graphene, from a June 29, 2015 Park Systems news release,

Park Systems, world-leader in atomic force microscopy (AFM) is hosting a webinar to provide advanced scientific research into new classes of Nanoscale Graphene-based materials poised to revolutionize industries such as semiconductor, material science, bio science and energy.   Touted as ‘the wonder material of the 21st Century’ by the researchers who were awarded the 2010 Nobel Prize in physics for their graphene research,  this carbon-based lightweight material is 200 times stronger than steel and one of the most promising and versatile materials ever discovered.

The Park Systems Webinar titled Graphene Based Nanomaterials and Films will be given by Professor Rigoberto Advincula of Case Western Reserve University on July 9, 2015 at 9am PST.  Prof. Advincula is an eminent professor, researcher and expert in the area of polymers, smart coatings, nanomaterials, surface analytical methods for a variety of applications.

“The discovery of graphene is but a continuing evolution on how we analyze, treat, synthesize carbon based nanomaterials which includes the fullerenes, nanotubes, and now C polymorph platelets called graphene,” explains Dr. Advincula.  “Graphene is used in many areas of research and potential applications for electronics, solid-state devices, biosensors, coatings and much more for numerous industries where there are opportunities to make quantum improvements in methods and materials.”

Graphene is part of the C polymorph family of nanomaterials and because of the platy nature of the basal plane, it’s reactivity on the edges, and various redox forms, it is an excellent thin film additive and component that can be grown by vapor deposition methods as well as exfoliation. Current research into dispersion, preparations, and patterning of graphene using Park Systems AFM to identify nanoscale characteristics and surface properties as well as conductivity indicates that numerous breakthroughs in materials and chemicals are on the horizon.

“Park AFM is the natural tool to investigate Graphene’s adsorbed state on a flat substrate as well as characterize its surface properties and conductivity because of the reliability and accuracy of the equipment,” adds Dr. Advincula who will give the Webinar on July 9. “AFM is useful in understanding the surface properties of these products but is equally valuable in failure analysis because of the capability to do in-situ or real time measurements of failure with a temperature stage or a magnetic field.”

Graphene-based Nanomaterials offer many innovations in industries such as electronics, semiconductor, life science, material science and bio science. Some potential advancements already being researched include flexible electronics, anti bacterial paper, actuators, electrochoromic devices and transistors.

“Park Systems is presenting this webinar as part of Park Nano Academy, which will offer valuable education and shared knowledge across many Nano Science Disciplines and Industries as a way to further enable NanoScale advancements,” comments Keibock Lee, Park Systems President.  “We invite all curious Nano Researchers to join our webinars and educational forums to launch innovative ideas that propel us into future Nano Scientific Technologies.”

The webinar will highlight how the research into is conducted and present some of the findings by Professor Rigoberto Advincula of Case Western Reserve University.

This webinar is available at no cost and is part of Park Systems Nano Academy.

To register go to: http://www.parkafm.com/index.php/medias/nano-academy/webinars/115-webinars/486-nanomaterials-webinar-july-9-2015

Enjoy!

Nanotech and the oil and gas industry: a webinar

How serendipitous! I stumbled on an announcement from Park Systems for a webinar designed for the oil and gas industry after my June 8, 2015 post featuring Abakan and its new Alberta (Canada)-based cladding facility designed for oil and gas pipes in particular. From a June 8, 2015 news item on Nanowerk,

Park Systems, world-leader in atomic force microscopy (AFM) today announced a webinar to provide next generation technology to improve oil and gas production in both traditional drilling and hydraulic fracturing for oil & gas producers and equipment manufacturers as they continue to pursue the latest developments in production efficiencies.

A June 8, 2015 Park Systems news release, which originated the news item, expands on the theme,

The oil and gas industry is ripe for innovation and the cost of extracting oil can be reduced. Research at PETRO Case Consortium is uncovering new materials, chemicals and coatings that improves yield and reduce costs and with an eye towards diminishing the impact on our environment. This webinar is part of an ongoing series offered by Park System’s new Nano Academy, a platform for providing education and shared knowledge on the latest advancements across a wide spectrum of nanosciences.

This webinar titled Nanostructured Polymers and Nanomaterials for Oil & Gas will be given June 11 [2015] by Dr. Rigoberto Advincula, Director of the Petro Case Consortium and Professor with the Department of Macromolecular Science and Engineering at Case Western Reserve University and is designed to offer innovations in microscopy nanotechnology for oil & gas producers and suppliers.

“Our best in class AFM equipment registers nanoparticle observations and analysis not previously available that extends the ability to analyze chemicals and materials to develop the optimum efficiency,” said Keibock Lee, President of Park Systems. “We are proud to offer this webinar for the oil & gas industry, showcasing Dr. Advincula’s outstanding contribution towards cost reduction and sustainability for the current energy producers and paving the way for future innovations that can enable global energy solutions.”

PETRO Case Consortium at Case Western [Reserve] University, led by Dr. Advincula, is working hard to ensure that the industry can catch up with new technology and apply it to oil & gas production that improves productivity by creating longer lasting concrete, coatings and apply other methods to increase yield in production. This webinar is the first of a series that will cover multiple topics related to nano scale developments across a wide variety of research applications and bio scientific fields.
“Hydraulic fracturing and directional drilling has unlocked many resources,” states Dr. Advincula. “Revolutionary new microscopy technology provided thru Park Systems AFM (Atomic Force Microscopy) and new innovations in chemical and material research indicates that there is a defined opportunity to use the advances in chemistry, materials, and nanoscience to make valuable industry process updates.”

For the last 10 years there has been an increase in interest and research for new materials useful for upstream, midstream, and downstream processes to effectively find function in demanding environments including directional drilling and hydraulic fracturing. High temperature high pressure (HT/HP) and brine conditions pose a challenge for emulsification, demulsification, and viscosity of drilling fluids. Usually the “easy” oil or conventional oil has allowed technologies even dating back to the first oil well in Pennsylvania to become very profitable. But with high pressure high temperature (HPHT) conditions in the most challenging wells, many of the established technologies and materials do not suffice.

The discovery driven group, PETRO Case Consortium at Case Western University, a Park AFM user, investigates the area of molecular, macromolecular, and supramolecular synthesis and structure of polymers and nanomaterials capable of controlled-assembly to form ultrathin films and dispersions with the aim of finding new technologies and materials that improve and replace established oil and gas field formations.

For instance, the evaluation of chemicals and changing or altering the formulas can greatly improve production yields. Different chemicals used for the field include inhibitors for scaling, fouling, corrosion, asphaltene control, formation damage, differential pressures in multiphase environments which will be met by new synthesis methods including metathesis reactions, bio based feedstocks, new polymer surfactants, living polymers, and nanoparticle. Other uses of new chemical technologies include tracers and reporters for geomapping and well connectivity, as well as different types of fluid loss agents that prevent formation damage or keep well integrity, and smart and stimuli-responsive nanoparticles that can be used for improving gelation.

This webinar is available at no cost and is part of Park Systems Nano Academy which will offer valuable education and shared knowledge across many Nano Science Disciplines and Industries as a way to further enable NanoScale advancements. To register go to: http://bit.do/polyoilgas

Webinar logistics (from the Park Systems news release),

About Webinar
Title: Nanostructured Polymers and Nanomaterials for Oil & Gas
Date: June 11, 2015
Time: 9am PST
To Register, go to: http://bit.do/polyoilgas
Pre-requisite: Knowledge of oil field chemicals and rubber materials is preferred but not required.

Here’s more about the expert (from the news release),

About Prof. Rigoberto Advincula
Prof. Rigoberto Advincula, Director of the Petro Case Consortium, is recognized industry-wide as an expert regarding polymer and materials challenges of the oil-gas industry. He is currently a Professor with the Department of Macromolecular Science and Engineering at Case Western Reserve University and is the recipient of numerous awards including Fellow of the American Chemical Society, Herman Mark Scholar Award of the Polymer Division, and Humboldt Fellow.

The news release also included some information about Park Systems,

About Park Systems
Park Systems is a world-leading manufacturer of atomic force microscopy (AFM) systems with a complete range of products for researchers and industry engineers in chemistry, materials, physics, life sciences, semiconductor and data storage industries. Park’s products are used by over a thousand of institutions and corporations worldwide. Park’s AFM provides highest data accuracy at nanoscale resolution, superior productivity, and lowest operating cost thanks to its unique technology and innovative engineering. Park Systems, Inc. is headquartered in Santa Clara, California with its global manufacturing, and R&D headquarters in Korea. Park’s products are sold and supported worldwide with regional headquarters in the US, Korea, Japan, and Singapore, and distribution partners throughout Europe, Asia, and America. Please visit http://www.parkafm.com or call 408-986-1110 for more information.

So there you have it.

Virtual Reality (VR) becomes educational (at Case Western Reserve University and Miami Children’s Hospital)

I have two virtual reality news bits the most recent concerning Case Western Reserve University (CWRU; located in Cleveland, Ohio) and Microsoft’s HoloLens in an April 29, 2015 CWRU press release (also on EurekAlert), Note: Some of this academic press release reads like marketing collateral,

Case Western Reserve University Radiology Professor Mark Griswold knew his world had changed the moment he first used a prototype of Microsoft’s HoloLens headset. Two months later, one of the university’s medical students illustrated exactly why.

“There’s the aortic valve,” Satyam Ghodasara exclaimed as he used Microsoft’s device to examine a holographic heart. “Now I understand.”

Today, Griswold told tens of thousands of people how HoloLens can transform learning across countless subjects, including those as complex as the human body. Speaking to an in-person and online audience at Microsoft’s annual Build conference, he highlighted disciplines as disparate as art history and engineering–but started with a holographic heart. In traditional anatomy, after all, students like Ghodasara cut into cadavers to understand the body’s intricacies.

With HoloLens, Griswold explained, “you see it truly in 3D. You can take parts in and out. You can turn it around. You can see the blood pumping–the entire system.”

In other words, technology not only can match existing educational methods–it can actually improve upon them. Which, in many ways, is why Cleveland Clinic CEO Toby Cosgrove contacted then-Microsoft executive Craig Mundie in 2013, after the hospital and university first agreed to partner on a new education building.

“We launched this collaboration to prepare students for a health care future that is still being imagined,” Cleveland Clinic CEO Delos “Toby” Cosgrove said of what has become a 485,000-square-foot Health Education Campus project. “By combining a state-of-the-art structure, pioneering technology, and cutting-edge teaching techniques, we will provide them the innovative education required to lead in this new era.”

As Cosgrove, Case Western Reserve President Barbara R. Snyder and other academic leaders engaged more extensively with Microsoft, the more potential everyone saw.

“For more than a century, our medical school has been renowned for inventing and reinventing approaches to teaching and learning that take root nationwide,” President Snyder said. “When we match that expertise with the interdisciplinary knowledge of our faculty, we create a rich environment to explore the educational potential of Microsoft’s extraordinary technology.”

After a small group including Griswold, engineering professor Marc Buchner and Cleveland Clinic education technology leader Neil Mehta first experienced HoloLens in December, the faculty returned to Cleveland to create a core team dedicated to exploring the technology’s academic potential. In February, 10 members of the team–including Ghodasara–returned to Microsoft for a HoloLens programming deep dive.

Ghodasara already had taken the traditional anatomy class at Case Western Reserve, but it wasn’t until he used the HoloLens headset that he first visualized the aortic valve in its entirety–unobstructed by other elements of the cardiac system and undamaged by earlier dissection efforts. Members of the Microsoft team were in the room when Ghodasara had his “aha” moment; a few weeks later, the heart demonstration became part of the Build conference agenda.

Case Western Reserve is the only university represented during the three-day event, a distinction Griswold attributes in part to the core team’s breadth of expertise and collegial approach.

“Without all of those people coming together,” Griswold said, “this would not have happened.”

When Griswold took the stage as part of Microsoft’s opening keynote at the Build conference, Ghodasara, Buchner and Chief Information Officer Sue Workman also were in the audience. Back in Cleveland, three of Professor Buchner’s undergraduates–John Billingsley, Henry Eastman and Tim Sesler–demonstrated some of the potential of the HoloLens technology live in the Tinkham Veale University Center.

Buchner, whose specialties include simulation and game design, believes Microsoft’s innovation “has the capability to transform engineering education.”

Because the technology is relatively easy to use, students will be able to build, operate and analyze all manner of devices and systems. “[It will] encourage experimentation,” Buchner said, “leading to deeper understanding and improved product design.”

In truth, HoloLens ultimately could have applications for dozens of Case Western Reserve’s academic programs. NASA’s Jet Propulsion Laboratory already has worked with Microsoft to develop software that will allow Earth-based scientists to work on Mars with a specially designed rover vehicle. A similar collaboration could enable students here to take part in archeological digs around the world. Or astronomy students could stand in the midst of colliding galaxies, securing front-row view of the unfolding chaos. Art history professors could present masterpieces in their original settings–a centuries-old castle, or even the Sistine Chapel.

“The whole campus has the potential to use this,” Griswold said. “Our ability to use this for education is almost limitless.”

For now, however, the top priority is creating a full digital anatomy curriculum, a process launched with the advent of the Health Education Campus, and now experiencing even greater momentum. Among the key collaborators are a team of medical students and anatomy and radiology faculty who are already investigating the use of these kinds of technology. This team, led by Amy Wilson­Delfosse, the medical school’s associate dean for curriculum, and Suzanne Wish-Baratz, an assistant professor who is one of the primary leaders of anatomy education, fully expects to have a digital curriculum ready for the new Health Education Campus.

Also essential, Griswold said, has been the advice and assistance of Microsoft’s HoloLens team and executives.

“It’s been a joy to work with them. They have been so friendly, so collaborative, so willing to work with us on this,” Griswold said. “We’re going to do incredible things together.”

Ohio is not the only state where virtual reality is being incorporated into medical education.

Florida

From an April 30, 2015 Next Galaxy Corp. news release,

Incorporating eye gaze control, gestures, and voice commands while “walking around” inside an emergency medical experience, Next Galaxy’s Virtual Reality Model educates participants far beyond today’s methodology of passively watching video and taking written tests.

Next Galaxy Corp (OTC: NXGA) recently announced the signing of an agreement with Miami Children’s Hospital to use the Company’s VR Model to develop immersive Virtual Reality medical instructional content for patient and medical professional education. Per the multi-year agreement, Next Galaxy and Miami Children’s Hospital are jointly developing VR Instructionals on cardiopulmonary resuscitation (CPR) and other lifesaving procedures, which will be released as an application for smartphones.

Assessments are incorporated directly into the medical VR models, creating situations where participants are required to make the appropriate decisions about proper techniques. The Virtual CPR instructional will measure metrics and provide real-time feedback ensuring participants accurately perform CPR techniques. Further, the instructional will explain any mistake and prompt users to try again when errors are made. Supportive messages are delivered upon success.

The medical VR models will be viewable through smartphones and desktops as 3D, and via VR devices such as Google Cardboard, VRONE and Oculus Rift.

About Next Galaxy Corporation

Next Galaxy Corporation is a leading developer of innovative content solutions and fully Immersive Consumer Virtual Reality technology. The Company’s flagship consumer product in development is CEEK, a next-generation fully immersive entertainment and educational social virtual reality platform featuring a combination of live action and 3D experiences. Next Galaxy’s CEEK simulates the communal experience of attending events, such as concerts, sporting events, movies or conferences through Virtual Reality. Next Galaxy is developing entertainment and educational experiences for VR Cinema, VR Concerts, VR Sports, VR Business, VR Tourism and more. In short, Next Galaxy is building the meeting places of the future. For further information, visit www.nextgalaxycorp.com

This seems to be the second time this information has been distributed (March 11, 2015 news release on PRNewswire), a widely adopted practice. Consequently and thankfully, there’s a March 11, 2015 article by Celia Ampel for the South Florida Business Journal which provides more details about the technology and explaining how a smartphone fits into virtual reality,

The best way to learn CPR is an immersive experience, Miami Children’s Hospital leaders believe — not a video.

“If I’m watching a video, I can pause and count, but there’s no way to tell if I counted to six or seven,” Next Galaxy President Mary Spio said. “Because [the virtual reality application] is voice-activated, they’re going to be able to count out loud and self-assess whether they’re doing it correctly.”

Next Galaxy (Pink Sheets: NXGA)’s virtual reality technology uses a smartphone app. Users can put their smartphone into a virtual reality headset for an immersive experience, or see 3D content through the phone.

The application will be available to the public in the next few months, Spio said.

This deal and another with Miami-Dade Country Public Schools are transforming Next Galaxy Corp according to Ampel’s article,

The five-person company will be hiring about 20 full-time employees in the next six months, focusing on developers with 3D modeling and gaming experience, she said.

Quadrupling the size of your company in six months can be quite a challenge. I wish them good luck with their expansion and their virtual reality course materials.

As to what all this mixed-reality/virtual reality might look like, there’s this image from Case Western Reserve University,

Courtesy: Case Western Reserve University

Courtesy: Case Western Reserve University

High-order Brownian motion observed

A Nov. 17, 2014 news item on ScienceDaily highlights a new technique for observing Brownian motion,

For the first time, scientists have vividly mapped the shapes and textures of high-order modes of Brownian motions–in this case, the collective macroscopic movement of molecules in microdisk resonators–researchers at Case Western Reserve University report.

To do this, they used a record-setting scanning optical interferometry technique, described in a study published today in the journal Nature Communications.

The new technology holds promise for multimodal sensing and signal processing, and to develop optical coding for computing and other information-processing functions by exploiting the spatially resolved multimode Brownian resonances and their splitting pairs of modes.

A Nov. 17, 2014 Case Western Reserve University news release on EurekAlert, which originated the news item, provides more information about the technique and the research,

Interferometry uses the interference of light waves reflected off a surface to measure distances, a technique invented by Case School of Applied Science physicist Albert A. Michelson (who won the Nobel prize in science in 1907). Michelson and Western Reserve University chemist Edward Morley used the instrument to famously disprove that light traveled through “luminous ether” in 1887, setting the groundwork for Albert Einstein’s theory of relativity.

The technology has evolved since then. The keys to Feng’s new interferometry technique are focusing a tighter-than-standard laser spot on the surface of novel silicon carbide microdisks.

The microdisks, which sit atop pedestals of silicon oxide like cymbals on stands, are extremely sensitive to the smallest fluctuations arising from Brownian motions, even at thermodynamic equilibrium. Hence, they exhibit very small oscillations without external driving forces. These oscillations include fundamental and higher modes, called thermomechanical resonances.

Some of the light from the laser reflects back to a sensor after striking the top surface of the silicon dioxide film. And some of the light is refracted through the film and reflected back on a different path, causing interference in the light waves.

The narrow laser spot scans the disk surface and measures movement, or displacement, of the disk with a sensitivity of about 7 femtometers per square-root of a hertz at room temperature, which researchers believe is a record for interferometric systems. To put that in perspective, the width of a hair is about 40 microns, and a femtometer is 100 million times smaller than a micron.

Although higher frequency modes have small motion amplitudes, the technology enabled the group to spatially map and clearly visualize the first through ninth Brownian modes in the high frequency band, ranging from 5.78 to 26.41 megahertz.

In addition to detecting the shapes and textures of Brownian motions, multimode mapping identified subtle structural imperfections and defects, which are ubiquitous but otherwise invisible, or can’t be quantified most of the time. This capability may be useful for probing the dynamics and propagation of defects and defect arrays in nanodevices, as well as for future engineering of controllable defects to manipulate information in silicon carbide nanostructures

The high sensitivity and spatial resolution also enabled them to identify mode splitting, crossing and degeneracy, spatial asymmetry and other effects that may be used to encode information with increasing complexity. The researchers are continuing to explore the capabilities of the technology.

Here’s a link to and a citation for the paper,

Spatial mapping of multimode Brownian motions in high-frequency ​silicon carbide microdisk resonators by Zenghui Wang, Jaesung Lee & Philip X. -L. Feng. Nature Communications 5, Article number: 5158 doi:10.1038/ncomms6158 Published 17 November 2014

This paper is behind a paywall.

For those who would like a little more information about Brownian motion, there’s this from its Wikipedia entry,

Brownian motion or pedesis (from Greek: πήδησις /pɛ̌ːdɛːsis/ “leaping”) is the random motion of particles suspended in a fluid (a liquid or a gas) resulting from their collision with the quick atoms or molecules in the gas or liquid. The term “Brownian motion” can also refer to the mathematical model used to describe such random movements, which is often called a particle theory.

The Wikipedia entry also includes this gif

This is a simulation of Brownian motion of a big particle (dust particle) that collides with a large set of smaller particles (molecules of a gas) which move with different velocities in different random directions. http://weelookang.blogspot.com/2010/06/ejs-open-source-brownian-motion-gas.html Lookang Author of computer model: Francisco Esquembre, Fu-Kwun and lookang - Own work

This is a simulation of Brownian motion of a big particle (dust particle) that collides with a large set of smaller particles (molecules of a gas) which move with different velocities in different random directions. http://weelookang.blogspot.com/2010/06/ejs-open-source-brownian-motion-gas.html
Lookang Author of computer model: Francisco Esquembre, Fu-Kwun and lookang – Own work

On a tangential and amusing note, Brown University celebrating its 250th anniversary this year (2014) commissioned a Brownian Motion composition as part of its commemoration activities (from a Feb. 21, 2014 Brown University news release),

While Brown University and its neighbors celebrate the University’s first 250 years during the Opening Celebration Friday and Saturday, March 7-8, 2014, some new history will be made as well. On Friday night, the Brown University Wind Symphony will present the world premier of Brownian Motion, a piece commissioned for the semiquincentenary.

Written by the composer and saxophonist Patrick Zimmerli, the commission was funded by Edward Guiliano, a 1972 Brown graduate who was president of the Brown Band and founded the Brown Wind Ensemble during his time on College Hill.

Zimmerli admits to feeling excitement when approached with the commission. “I didn’t go to Brown but I have many connections to people who did, and I was really looking forward to the challenge of writing for an undergraduate wind ensemble, something I’d never done before.”

McGarrell [Matthew McGarrell, director of bands at Brown] and Zimmerli met last summer to talk about the commission for the first time. Aside from sending Zimmerli a few pieces to use as models, McGarrell gave the composer free reign over over everything from the feel to the length of the piece.

The resulting composition, which Zimmerli presented to McGarrell at the beginning of January, is dominated by jazz rhythms, with some nods to vernacular musics, including Caribbean and calypso, mixed in.

“The piece has several different moods but overall it is celebratory,” Zimmerli said. “After all it’s a birthday piece. It’s meant to be challenging but fun for the players.”

Listeners with a link to Brown may also find parts of the work familiar. Zimmerli subtly weaves an early melody known as “Araby’s Daughter” — Brown’s Alma Mater — throughout the piece, building on it until it’s played in its full glory by the French horns toward the end.

For inspiration, Zimmerli did extensive research on Brown’s early history and was intrigued to learn that Brown’s founding was initially opposed by a group of preachers who had a mistrust for those who had been formally educated. The result is a theme — “learning is evil,” a nod to those early roots — that winds its way throughout the song.

“Brown is an amazing example of an institution that has been able to evolve and transform itself from within, and I thought that fact should be celebrated,” said Zimmerli.

Other parts of the song inspired the Brownian Motion name.

“There’s a jagged theme toward the beginning of the piece that is a bit cheeky, even subversive. The way it moves and darts around through the instruments unexpectedly is what eventually led me to the actual title of the piece,” Zimmerli said.

“We knew we wanted to make it special concert,” said McGarrell of the program selections. “We wanted to reach both the Brown community in history, through the alumni, through musical representation, and we wanted to reach out to the extended Brown community in Rhode Island and southeastern New England, through history and intercultural outreach.”

The Brown musicians have been hard at work since the end of January learning Brownian Motion. While technically challenging, McGarrell said the students have been appreciating the skill level required and that “morale has remained high within the group.” Zimmerli arrives on campus on Wednesday, March 5, to help put the finishing touches on the performance.

There is a youtube video (over 60 mins.) of the Brownian Motion March 2014 performance.