Tag Archives: Catherine Griwkowsky

Canadian government funding announced for nanotechnology research in Saskatchewan and Alberta

Canada’s Western Economic Diversification and Canada Research Chairs (CRC) programmes both made nanotechnology funding announcements late last week on March 28, 2014.

From a March 28, 2014 news item on CJME radio online,

Funding for nanotechnology was announced at the University of Saskatchewan (U of S) on Friday [March 28, 2014].

Researchers will work on developing nanostructured coatings for parts of artificial joints and even mining equipment.

The $183,946 investment from the Western Economic Diversification Canada will go towards purchasing tailor-made equipment that will help apply the coating.

A March 29, 2014 article by Scott Larson for the Leader-Post provides more details,

In the near future when someone has a hip replacement, the new joint might actually last a lifetime thanks to cutting edge nanotechnology research being done by Qiaoqin Yang and her team. Yang, Canada Research Chair in nanoengineering coating technologies and professor of mechanical engineering at the University of Saskatchewan, has received $183,946 from Western Economic Diversification (WD) to purchase specially made equipment for nanotechnology research.

The equipment will help in developing and testing nanostructured coatings to increase the durability of hard-to-reach industrial and medical components.

“The diamond-based coating is biocompatible and has high wear resistance,” Yang said of the coating material.

There will be four industry-specific coating prototypes tested for projects such as solar energy systems, artificial joints, and mining and oilsands equipment.

Yang said artificial joints usually only last 10-20 years.

I have written about hip and knee replacements and issues with the materials most recently in a Feb. 5, 2013 posting.

As for the CRC announcement about the University of Alberta, here’s more from the March 28, 2014 article by Catherine Griwkowsky for the Edmonton Sun,

The Canadian Research Chairs funding announcement means 11 chair appointments, renewals and tier advancements, part of the 100 faculty who are chair holders at the university.

Carlo Montemagno, Canada Research Chair in Intelligent Nanosystems, said the funding will usher in the next generation in nanotechnology.

“It’s not just the money, it’s the recognition and the visibility that comes with the title,” Montemagno said. “That provides an opportunity for me to be more effective recruiting talent into my laboratory.”

He said the chair position at the University of Alberta allows him to go after riskier projects with a higher impact.

“It provides a nucleating force that allows us to gravitationally pull in talent and resources to position ourselves as global leaders,” Montemagno said.

Previously, he had worked at Cornell University, department head at University of California Los Angeles and dean of engineering at the University of Cincinnati.

Minister of State for Science and Technology Ed Holder said the $88 million will help with Canada’s economic prosperity and will attract more researchers to the country from around the world. …

“I think it’s a huge compliment to what the government of Canada is doing in terms of research and I think it’s a great, great credit to those Canadians who say I can do the best and the greatest research right here in Canada.

He said the success is attracting Canadians back.

Holder, who took over as science boss just over a week ago, said the government has received acknowledgment from granting councils. …

Holder said the proposed budget has an additional $1.5 billion in new money in the budget for research.

Upcoming research projects from the National Institute for Nanotechnology at the University of Alberta:

Artificially engineered system that incorporates the process of photosynthesis in a non-living thing with living elements to convert CO2 emissions to a sellable commodity like rare earth and precious metals.
Extracting minerals and chemicals in waste treatment such as tailings ponds, to clean up polluted water and take out valuable resources.
Cleaning and purifying water with an engineered variant of a molecule 100 times more efficient than current technology, opening land for agricultural development, or industrial plants.

Montemagno has an intriguing turn of phrase “a nucleating force that allows us to gravitationally pull in talent and resources” which I think could be summed up as “money lets us buy what we want with regard to researchers and equipment.” (I first mentioned Montegmagno in a Nov. 19, 2013 post about Alberta’s nanotechnology-focused Ingenuity Lab which he heads.) Holder’s comments are ‘on message’ as they say these days or, as old-timers would say, his comments follow the government’s script.

The listing of the National Institute of Nanotechnology (NINT) projects in Griwkowsky’s article seems a bit enigmatic since there’s no explanation offered as to why these are being included in the newspaper article. The confusion can be cleared up by reading the March 28, 2014 University of Alberta news release,

“Our work is about harnessing the power of ‘n’—nature, nanotechnology and networks,” said Montemagno, one of 11 U of A faculty members who received CRC appointments, renewals or tier advancements. “We use living systems in nature as the inspiration; we use nanotechnology, the ability to manipulate matter at its smallest scale; and we build systems in the understanding that we have to make these small elements work together in complex networks.”

The physical home of this work is Ingenuity Lab, a collaboration between the U of A, the National Institute for Nanotechnology and Alberta Innovates – Technology Futures. Montemagno is the director, and he has assembled a team of top scientists with backgrounds in biochemistry, organic chemistry, neurobiology, molecular biology, physics, computer science, engineering and material science.

Turning CO2 in something valuable

Reducing greenhouse gases is one of the challenges his team is working to address, by capturing carbon dioxide emissions and converting them into high-value chemicals.

Montemagno said the process involves mimicking photosynthesis, using engineered molecules to create a structure that metabolizes CO2. Unlike fermentation and other processes used to convert chemicals, this method is far more energy-efficient, he said.

“You make something that has the same sort of features that are associated with a living process that you want to emulate.”

In another project, Montemagno’s team has turned to cells, viruses and bacteria and how they identify chemicals to react to their environment, with the aim of developing “an exquisite molecular recognition technology” that can find rare precious metals in dilute quantities for extraction. This type of bio-mining is being explored to transform waste from a copper mine into a valuable product, and ultimately could benefit oilsands operations as well.

“The idea is converting waste into a resource and doing it in a way in which you provide more economic opportunity while you’re being a stronger steward of our natural resources.”

Congratulations to the University of Saskatchewan and the University of Alberta!

(A University of British Columbia CRC founding announcement was mentioned in my March 31, 2014 posting about Ed Holder, the new Minister of State (Science and Technology).

Alberta gave its cellulose nanocrystal (or nanocrystalline cellolose) production plant a soft launch in September 2013

It’s been a little over two years since Alberta’s proposed cellulose nanocrystal (CNC), then called nanocrystalline cellulose (NCC), pilot plant was first announced (my July 5, 2011 posting). I gather that the plant was quietly opened in Sept. 2013. Finding a news release about the event has proved to be a challenge. The Alberta Innovates website does not list it in its Newsroom while the Alberta Innovates Technology Futures website does list a news release (September 12, 2013Alberta’s one-of-a-kind CNC pilot plant commissioned: Cellulose-based ‘wonder material’ now available to researchers, industry partnersf), despite numerous efforts on my part (try it yourself), I’m unable to access it. Happily, I was able to track down some information elsewhere.

First (in the order in which I found the information), there’s an Oct. 2, 2013 news item on the WorkingForest.com website submitted by Pulp and Paper Canada),

Alberta’s cellulose nanocrystals (CNC) pilot plant, which produces up to 100 kilograms of CNC per week, was commissioned in early September at Alberta Innovates-Technology Futures’ (AITF) Mill Woods facility before a crowd of researchers, industry leaders and government representatives.

The $5.5-million pilot plant, created through a collaboration of the governments of Canada and Alberta in partnership with industry under the Western Economic Partnership Agreement (WEPA), uses wood and straw pulp from plants such as flax and hemp to create CNC for testing in commercial applications that will lead to production.

“Alberta Innovates-Technology Futures is proud to host and operate Western Canada’s only CNC pilot plant,” said Stephen Lougheed, AITF’s president and CEO. “We’re able to provide researchers with more CNC than ever before, thereby accelerating the development of commercial applications.”

The grand opening of the CNC pilot plant’s is planned for 2014.

Then, there was more information about the plant and the event in Catherine Griwkowsky’s Sept. 12, 2013 article for the Edmonton Sun,

A new cellulose nanocrystals (CNCs) pilot plant will take wood and agricultural fires and turn it into a form that can make products stronger, give them sunlight-absorbing properties, add a negative electromagnetic charge and more.

The $5.5-million project in Mill Woods will churn out up to 100 kilograms of the crystals each week.

Technical Lead Frank Tosto said researchers will study various properties of the crystals, and work with an internal team as well as external industry and other researchers to transform knowledge of the properties into ideas for applications. Later, the team may experiment with unconventional sources of cellulose.

The CNCs can be used for drilling fluids, paints, industrial coatings, automotive components, building materials, plastics and packaging.

The process [of refining hemp, etc.] breaks down cellulose into smaller building blocks using a chemical process of acid hydrolysis, that separates crystal formations in cellulose from other structures. The width is between five to 10 nanometres with a length of 150 to 200 nanometers. To scale, cellulose fibre would be the size of a hockey rink and the nano crystal would be like a pen or pencil, he explained.

Ultimately, Tosto hopes they will find commercial applications for the CNCs. The pilot should last five to seven years. He said it’s hard to think outside the box when they don’t know where all the boxes are.

I’d love to know if any of the entrepreneurs who contacted me privately about accessing CNC so they could develop new applications are now able to purchase product from the Alberta plant or from the one in Quebec (CelluForce), which had a stockpile last I heard (my Oct. 3, 2013 posting). It seems odd to be building another plant when the country’s first such plant has stopped production. Meanwhile, there’s some action on the international scene. An Israeli startup company, Melodea has developed its own CNC/NCC extraction process and has received money to develop applications, from my Oct. 31, 2013 posting),

Melodea Ltd. is developing an economic ally viable industrial process for the extraction of NCC from the sludge of the paper industry, a waste stream produced at millions of tons around the world. The core of the novel technology was developed by the lab of Professor Oded Shoseyov from the Hebrew University of Jerusalem and was licensed exclusively to Melodea.

Moreover, the company develops unique technologies to self-assemble the NCC into ecologically friendly foams for industrial applications.

Melodea Ltd. announced today that it has been awarded above 1,000,000 Euro in 3 projects of the European Union Seventh Framework Program (FP7).

You’ll note Melodea’s process extracts CNC from the paper industry’s sludge which leads me to this question: will there be any discussion of this extracting CNC from sludge technique at the 2014 TAPPI (Technical Association for the Pulp, Paper, Packaging and Converting Industries) nanotechnology conference being held in Vancouver (Canada), June 23-26, 2014 (mentioned in my Nov. 14, 2013 posting about the conference’s submission deadline, Nov. 22, 2013)?

University of Alberta, Movember, and nanomedicine cancer research

Not sure when November became Movember but in keeping with the theme researchers at the University of Alberta have just published their work on developing ‘homing beacon drugs’ that eliminate cancerous cells only while leaving healthy cells to go about their work. From the Nov. 20, 2012 University of Alberta news release by Raquel Maurier (Note: I have removed some links),

A medical researcher with the University of Alberta and his team just published their findings about their work on developing “homing beacon drugs” that kill only cancer cells, not healthy ones, thanks to nanotechnology.

John Lewis, the Sojonky Chair in Prostate Cancer Research with the Faculty of Medicine & Dentistry, published his findings in the peer-reviewed journal, Nano Letters. He is also an associate professor in the Department of Oncology at the U of A, the director of the Translational Prostate Cancer Research Group and a fellow of the National Institute for Nanotechnology.

Lewis noted chemotherapy goes through the body and kills any cells that are dividing, even healthy ones—which is why cancer patients have immune-system problems, hair loss, nausea and skin problems.

“We are developing smart drugs that determine which are the cancer cells and which aren’t, then selectively kill only the cancer cells. The drugs look for a protein that is only found in cancer cells, not normal cells. This system acts like a homing beacon for tumours.”

These drugs, tested to date in only animal lab models, could be used within a week of cancer diagnoses, predicts Lewis. The drugs would target cancerous cells throughout the body, attacking sneaky cancer cells that have already escaped and grown outside the site of the main tumour.

Lewis isn’t sure when these homing beacon drugs could be available for physicians to use with patients, but hopes his works paves the way for patient-centred therapies.

Catherine Griwkowsky posted a Nov. 20, 2012 article and video about the research on the Edmonton Sun website which features an interview with the lead researcher, Choi-Fong Cho,

Fong Cho, lead researcher on the study published in the peer-reviewed Nano Letters, said the nanoparticles can be used both for imaging and for drug delivery.

“For my purpose, you put in something that binds to your cancer directly to a particle that leads to your cancer and the nanoparticle will light up the cancer,” she said.

“You could also, for example, put drugs on it and deliver the drugs specifically to the tumour without harming the surrounding cells and tissues that causes a lot of side effects.”

The lab is also looking at ways of identifying and stopping metastasis …

In keeping with the Movember theme, here’s John Lewis,

UAlberta medical researcher John Lewis sports a Movember mustache to support prostate cancer awareness and research. Lewis and his team are developing ‘homing beacon drugs’ that can target cancer cells while sparing healthy cells. Their findings could help improve survival rates and quality of life for people undergoing cancer treatment. (downloaded from http://www.news.ualberta.ca/article.aspx?id=4CD917F418E3492F92CCCDDA7B8221640)

Here’s a citation for Cho’s and Lewis’ article,

Discovery of Novel Integrin Ligands from Combinatorial Libraries Using a Multiplex “Beads on a Bead” Approach by Choi-Fong Cho, Giulio A. Amadei, Daniel Breadner, Leonard G. Luyt, and John D. Lewis in Nano Lett., 2012, 12 (11), pp 5957–5965 DOI: 10.1021/nl3034043 Publication Date (Web): October 25, 2012 Copyright © 2012 American Chemical Society

This article is behind a paywall.