Tag Archives: Concordia University

Genetic engineering: an eggplant in Bangladesh and a synthetic biology grant at Concordia University (Canada)

I have two bits of genetic engineering news.

Eggplants in Bangladesh

I always marvel at their beauty,

Bt eggplant is the first genetically engineered food crop to be successfully introduced in South Asia. The crop is helping some of the world’s poorest farmers feed their families and communities while reducing the use of pesticides. Photo by Cornell Alliance for Science.

A July 17, 2018 news item on phys.org describes a genetic engineering application,

Ansar Ali earned just 11,000 taka – about $130 U.S. dollars – from eggplant he grew last year in Bangladesh. This year, after planting Bt eggplant, he brought home more than double that amount, 27,000 taka. It’s a life-changing improvement for a subsistence farmer like Ali.

Bt eggplant, or brinjal as it’s known in Bangladesh, is the first genetically engineered food crop to be successfully introduced in South Asia. Bt brinjal is helping some of the world’s poorest farmers to feed their families and communities, improve profits and dramatically reduce pesticide use. That’s according to Tony Shelton, Cornell professor of entomology and director of the Bt brinjal project funded by the United States Agency for International Development (USAID). Shelton and Jahangir Hossain, the country coordinator for the project in Bangladesh, lead the Cornell initiative to get these seeds into the hands of the small-scale, resource-poor farmers who grow a crop consumed daily by millions of Bangladeshis.

A July 11, 2018 Cornell University news release by Krisy Gashler, which originated the news item, expands on the theme (Note: Links have been removed),

Bt brinjal was first developed by the Indian seed company Mahyco in the early 2000s. Scientists inserted a gene from the bacterium Bacillus thuringiensis (thus the name, Bt) into nine brinjal varieties. The plants were engineered to resist the fruit and shoot borer, a devastating insect whose larvae bore into the stem and fruit of an eggplant. The insects cause up to 80 percent crop loss.

The Bt protein produced by the engineered eggplant causes the fruit and shoot borer larva to stop feeding, but is safe for humans consuming the eggplant, as proven through years of biosafety trials. In fact, Bt is commonly used by organic farmers to control caterpillars but has to be sprayed frequently to be effective. The Bt eggplant produces essentially the same protein as in the spray. More than 80 percent of field corn and cotton grown in the U.S. contains a Bt gene for insect control.

“Farmers growing Bt brinjal in Bangladesh are seeing three times the production of other brinjal varieties, at half the production cost, and are getting better prices at the market,” Hossain said.

A recent survey found 50 percent of farmers in Bangladesh said that they experienced illness due to the intense spraying of insecticides. Most farmers work in bare feet and without eye protection, leading to pesticide exposure that causes skin and eye irritation, and vomiting.

“It’s terrible for these farmers’ health and the health of the environment to spray so much,” said Shelton, who found that pesticide use on Bt eggplant was reduced as much as 92 percent in commercial Bt brinjal plantings. “Bt brinjal is a solution that’s really making a difference in people’s lives.”

Alhaz Uddin, a farmer in the Tangail district, made 6,000 taka growing traditional brinjal, but had to spend 4,000 taka on pesticides to combat fruit and shoot borer.

“I sprayed pesticides several times in a week,” he said. “I got sick many times during the spray.”

Mahyco initially wanted to introduce Bt brinjal in India and underwent years of successful safety testing. But in 2010, due to pressure from anti-biotechnology groups, the Indian minister of the environment placed a moratorium on the seeds. It is still in effect today, leaving brinjal farmers there without the effective and safe method of control available to their neighbors in Bangladesh.

Even before the Indian moratorium, Cornell scientists hosted delegations from Bangladesh that wanted to learn about Bt brinjal and the Agricultural Biotechnology Support Project II (ABSP II), a consortium of public and private institutions in Asia and Africa intended to help with the commercial development, regulatory approval and dissemination of bio-engineered crops, including Bt brinjal.

Cornell worked with USAID, Mahyco and the Bangladesh Agricultural Research Institute to secure regulatory approval, and in 2014 the Bangladeshi government distributed a small number of Bt brinjal plants to 20 farmers in four districts. The next year 108 farmers grew Bt brinjal, and the following year the number of farmers more than doubled to 250. In 2017 the number increased to 6,512 and in 2018 to 27,012. The numbers are likely even higher, according to Shelton, as there are no constraints against farmers saving seeds and replanting.

“Farmers who plant Bt brinjal are required to plant a small perimeter of traditional brinjal around the Bt variety; research has shown that the insects will infest plants in the buffer area, and this will slow their evolutionary development of resistance to the Bt plants,” Shelton said.

In a March 2017 workshop, Bangladeshi Agriculture Minister Begum Matia Chowdhury called Bt brinjal “a success story of local and foreign collaboration.”

“We will be guided by the science-based information, not by the nonscientific whispering of a section of people,” Chowdhury said. “As human beings, it is our moral obligation that all people in our country should get food and not go to bed on an empty stomach. Biotechnology can play an important role in this effect.”

Here’s what an infested eggplant looks like,

Non-Bt eggplant infested with fruit and shoot borer. Photo by Cornell Alliance for Science

It looks more like a fig than an eggplant.

This is part of a more comprehensive project as revealed in a March 29, 2016 Cornell University news release issued on the occasion of a $4.8M, three-year grant from the U.S. Agency for International Development (USAID),

… The award supports USAID’s work under Feed the Future, the U.S. government’s global initiative to fight hunger and improve food security using agricultural science and technology.

In the Feed the Future South Asia Eggplant Improvement Partnership, Cornell will protect eggplant farmers from yield losses and improve their livelihoods in partnership with the Bangladesh Agricultural Research Institute (BARI) and the University of the Philippines at Los Baños. Eggplant, or brinjal, is a staple crop that is an important source of income and nutrition for farmers and consumers in South Asia.

Over the past decade, Cornell has led the Agricultural Biotechnology Support Project II (ABSPII), also funded by USAID, that prompted a consortium of institutions in Asia and Africa to use the tools of modern biotechnology, particularly genetic engineering, to improve crops to address major production constraints for which conventional plant breeding tools have not been effective.

In October 2013, Bangladesh became the first country in South Asia to approve commercial cultivation of a genetically engineered food crop. In February 2014, Matia Chowdhury, the Bangladesh minister of agriculture, released four varieties of Bt brinjal to 20 farmers. With the establishment of the 20 Bt brinjal demonstration plots in 2014 and 104 more in 2015, BARI reported a noticeable decrease in fruit and shoot borer infestation, increased yields, decreased use of pesticide and improved income for farmers.

The Feed the Future South Asia Eggplant Improvement Partnership addresses and integrates all elements of the commercialization process — including technology development, regulation, marketing, seed distribution, and product stewardship. It also provides strong platforms for policy development, capacity building, gender equality, outreach and communication.

Moving on from practical applications …

Canada’s synthetic biology training centre

It seems Concordia University (Montréa) is a major Canadian centre for all things ‘synthetic biological’. (from the History and Vision webpage on Concordia University’s Centre for Applied Synthetic Biology webspace),

History and vision

Emerging in 2012 from a collaboration between the Biology and Electrical and Computer Engineering Departments, the Centre received University-wide status in 2016 growing its membership to include Biochemistry, Journalism, Communication Studies, Mechanical, Industrial and Chemical Engineering.


Timeline

T17-36393-VPRG-Timeline-graphic-promo-v4

You can see the timeline does not yet include 2018 development(s). Also it started as “a collaboration between the Biology and Electrical and Computer Engineering Departments?” This suggests a vastly different approach to genetic engineering that that employed in the “eggplant” research. From a July 16, 2018 posting on the Genome Alberta blog,

The Natural Sciences and Engineering Research Council of Canada (NSERC) has committed $1.65 million dollars over six years to establish a research and training program at Concordia’s Centre for Applied Synthetic Biology.

The funds were awarded after Malcolm Whiteway (…), professor of biology and the Canada Research Chair in Microbial Genomics, and the grant application team submitted a proposal to NSERC’s Collaborative Research and Training Experience (CREATE) program.

The Synthetic Biology Applications CREATE program — or SynBioApps — will help students acquire and develop important professional skills that complement their academic education and improve their job-readiness.

‘Concordia is a natural fit’

“As the Canadian leader in synthetic biology and as the home of the country’s only genome foundry, Concordia is a natural fit for a training program in this growing area of research,” says Christophe Guy, vice-president of Research and Graduate Studies.

“In offering a program like SynBioApps, we are providing our students with both a fundamental education in science and the business skills they’ll need to transition into their professional careers.”

The program’s aims are twofold: First, it will teach students how to design and construct cells and proteins for the development of new products related to human health, green technologies, and fundamental biological investigations. Second, it will provide cross-disciplinary training and internship opportunities through the university’s District 3 Innovation Center.

SynBioApps will be open to students from biology, biochemistry, engineering, computing, and mathematics.

“The ability to apply engineering approaches to biological systems promises to revolutionize both biology and industry,” says Whiteway, who is also a member of the Centre for Applied Synthetic Biology.

“The SynBioApps program at Concordia will provide a training program to develop the students who will both investigate the biology and build these industries.”

You can find out more about Concordia’s Centre for Applied Synthetic Biology here (there are jobs listed on their home page) and you can find information about the Synthetic Biology Applications (SynBioApps) training programme here.

AI fairytale and April 25, 2018 AI event at Canada Science and Technology Museum*** in Ottawa

These days it’s all about artificial intelligence (AI) or robots and often, it’s both. They’re everywhere and they will take everyone’s jobs, or not, depending on how you view them. Today, I’ve got two artificial intelligence items, the first of which may provoke writers’ anxieties.

Fairytales

The Princess and the Fox is a new fairytale by the Brothers Grimm or rather, their artificially intelligent surrogate according to an April 18, 2018 article on the British Broadcasting Corporation’s online news website,

It was recently reported that the meditation app Calm had published a “new” fairytale by the Brothers Grimm.

However, The Princess and the Fox was written not by the brothers, who died over 150 years ago, but by humans using an artificial intelligence (AI) tool.

It’s the first fairy tale written by an AI, claims Calm, and is the result of a collaboration with Botnik Studios – a community of writers, artists and developers. Calm says the technique could be referred to as “literary cloning”.

Botnik employees used a predictive-text program to generate words and phrases that might be found in the original Grimm fairytales. Human writers then pieced together sentences to form “the rough shape of a story”, according to Jamie Brew, chief executive of Botnik.

The full version is available to paying customers of Calm, but here’s a short extract:

“Once upon a time, there was a golden horse with a golden saddle and a beautiful purple flower in its hair. The horse would carry the flower to the village where the princess danced for joy at the thought of looking so beautiful and good.

Advertising for a meditation app?

Of course, it’s advertising and it’s ‘smart’ advertising (wordplay intended). Here’s a preview/trailer,

Blair Marnell’s April 18, 2018 article for SyFy Wire provides a bit more detail,

“You might call it a form of literary cloning,” said Calm co-founder Michael Acton Smith. Calm commissioned Botnik to use its predictive text program, Voicebox, to create a new Brothers Grimm story. But first, Voicebox was given the entire collected works of the Brothers Grimm to analyze, before it suggested phrases and sentences based upon those stories. Of course, human writers gave the program an assist when it came to laying out the plot. …

“The Brothers Grimm definitely have a reputation for darkness and many of their best-known tales are undoubtedly scary,” Peter Freedman told SYFY WIRE. Freedman is a spokesperson for Calm who was a part of the team behind the creation of this story. “In the process of machine-human collaboration that generated The Princess and The Fox, we did gently steer the story towards something with a more soothing, calm plot and vibe, that would make it work both as a new Grimm fairy tale and simultaneously as a Sleep Story on Calm.” [emphasis mine]

….

If Marnell’s article is to be believed, Peter Freedman doesn’t hold much hope for writers in the long-term future although we don’t need to start ‘battening down the hatches’ yet.

You can find Calm here.

You can find Botnik  here and Botnik Studios here.

 

AI at Ingenium [Canada Science and Technology Museum] on April 25, 2018

Formerly known (I believe) [*Read the comments for the clarification] as the Canada Science and Technology Museum, Ingenium is hosting a ‘sold out but there will be a livestream’ Google event. From Ingenium’s ‘Curiosity on Stage Evening Edition with Google – The AI Revolution‘ event page,

Join Google, Inc. and the Canada Science and Technology Museum for an evening of thought-provoking discussions about artificial intelligence.

[April 25, 2018
7:00 p.m. – 10:00 p.m. {ET}
Fees: Free]

Invited speakers from industry leaders Google, Facebook, Element AI and Deepmind will explore the intersection of artificial intelligence with robotics, arts, social impact and healthcare. The session will end with a panel discussion and question-and-answer period. Following the event, there will be a reception along with light refreshments and networking opportunities.

The event will be simultaneously translated into both official languages as well as available via livestream from the Museum’s YouTube channel.

Seating is limited

THIS EVENT IS NOW SOLD OUT. Please join us for the livestream from the Museum’s YouTube channel. https://www.youtube.com/cstmweb *** April 25, 2018: I received corrective information about the link for the livestream: https://youtu.be/jG84BIno5J4 from someone at Ingenium.***

Speakers

David Usher (Moderator)

David Usher is an artist, best-selling author, entrepreneur and keynote speaker. As a musician he has sold more than 1.4 million albums, won 4 Junos and has had #1 singles singing in English, French and Thai. When David is not making music, he is equally passionate about his other life, as a Geek. He is the founder of Reimagine AI, an artificial intelligence creative studio working at the intersection of art and artificial intelligence. David is also the founder and creative director of the non-profit, the Human Impact Lab at Concordia University [located in Montréal, Québec]. The Lab uses interactive storytelling to revisualize the story of climate change. David is the co-creator, with Dr. Damon Matthews, of the Climate Clock. Climate Clock has been presented all over the world including the United Nations COP 23 Climate Conference and is presently on a three-year tour with the Canada Museum of Science and Innovation’s Climate Change Exhibit.

Joelle Pineau (Facebook)

The AI Revolution:  From Ideas and Models to Building Smart Robots
Joelle Pineau is head of the Facebook AI Research Lab Montreal, and an Associate Professor and William Dawson Scholar at McGill University. Dr. Pineau’s research focuses on developing new models and algorithms for automatic planning and learning in partially-observable domains. She also applies these algorithms to complex problems in robotics, health-care, games and conversational agents. She serves on the editorial board of the Journal of Artificial Intelligence Research and the Journal of Machine Learning Research and is currently President of the International Machine Learning Society. She is a AAAI Fellow, a Senior Fellow of the Canadian Institute for Advanced Research (CIFAR) and in 2016 was named a member of the College of New Scholars, Artists and Scientists by the Royal Society of Canada.

Pablo Samuel Castro (Google)

Building an Intelligent Assistant for Music Creators
Pablo was born and raised in Quito, Ecuador, and moved to Montreal after high school to study at McGill. He stayed in Montreal for the next 10 years, finished his bachelors, worked at a flight simulator company, and then eventually obtained his masters and PhD at McGill, focusing on Reinforcement Learning. After his PhD Pablo did a 10-month postdoc in Paris before moving to Pittsburgh to join Google. He has worked at Google for almost 6 years, and is currently a research Software Engineer in Google Brain in Montreal, focusing on fundamental Reinforcement Learning research, as well as Machine Learning and Music. Aside from his interest in coding/AI/math, Pablo is an active musician (https://www.psctrio.com), loves running (5 marathons so far, including Boston!), and discussing politics and activism.

Philippe Beaudoin (Element AI)

Concrete AI-for-Good initiatives at Element AI
Philippe cofounded Element AI in 2016 and currently leads its applied lab and AI-for-Good initiatives. His team has helped tackle some of the biggest and most interesting business challenges using machine learning. Philippe holds a Ph.D in Computer Science and taught virtual bipeds to walk by themselves during his postdoc at UBC. He spent five years at Google as a Senior Developer and Technical Lead Manager, partly with the Chrome Machine Learning team. Philippe also founded ArcBees, specializing in cloud-based development. Prior to that he worked in the videogame and graphics hardware industries. When he has some free time, Philippe likes to invent new boardgames — the kind of games where he can still beat the AI!

Doina Precup (Deepmind)

Challenges and opportunities for the AI revolution in health care
Doina Precup splits her time between McGill University, where she co-directs the Reasoning and Learning Lab in the School of Computer Science, and DeepMind Montreal, where she leads the newly formed research team since October 2017.  She got her BSc degree in computer science form the Technical University Cluj-Napoca, Romania, and her MSc and PhD degrees from the University of Massachusetts-Amherst, where she was a Fulbright fellow. Her research interests are in the areas of reinforcement learning, deep learning, time series analysis, and diverse applications of machine learning in health care, automated control and other fields. She became a senior member of AAAI in 2015, a Canada Research Chair in Machine Learning in 2016 and a Senior Fellow of CIFAR in 2017.

Interesting, oui? Not a single expert from Ottawa or Toronto. Well, Element AI has an office in Toronto. Still, I wonder why this singular focus on AI in Montréal. After all, one of the current darlings of AI, machine learning, was developed at the University of Toronto which houses the Canadian Institute for Advanced Research (CIFAR),  the institution in charge of the Pan-Canadian Artificial Intelligence Strategy and the Vector Institutes (more about that in my March 31,2017 posting).

Enough with my musing: For those of us on the West Coast, there’s an opportunity to attend via livestream from 4 pm to 7 pm on April 25, 2018 on xxxxxxxxx. *** April 25, 2018: I received corrective information about the link for the livestream: https://youtu.be/jG84BIno5J4 and clarification as the relationship between Ingenium and the Canada Science and Technology Museum from someone at Ingenium.***

For more about Element AI, go here; for more about DeepMind, go here for information about parent company in the UK and the most I dug up about their Montréal office was this job posting; and, finally , Reimagine.AI is here.

nano tech 2017 being held in Tokyo from February 15-17, 2017

I found some news about the Alberta technology scene in the programme for Japan’s nano tech 2017 exhibition and conference to be held Feb. 15 – 17, 2017 in Tokyo. First, here’s more about the show in Japan from a Jan. 17, 2017 nano tech 2017 press release on Business Wire (also on Yahoo News),

The nano tech executive committee (chairman: Tomoji Kawai, Specially Appointed Professor, Osaka University) will be holding “nano tech 2017” – one of the world’s largest nanotechnology exhibitions, now in its 16th year – on February 15, 2017, at the Tokyo Big Sight convention center in Japan. 600 organizations (including over 40 first-time exhibitors) from 23 countries and regions are set to exhibit at the event in 1,000 booths, demonstrating revolutionary and cutting edge core technologies spanning such industries as automotive, aerospace, environment/energy, next-generation sensors, cutting-edge medicine, and more. Including attendees at the concurrently held exhibitions, the total number of visitors to the event is expected to exceed 50,000.

The theme of this year’s nano tech exhibition is “Open Nano Collaboration.” By bringing together organizations working in a wide variety of fields, the business matching event aims to promote joint development through cross-field collaboration.

Special Symposium: “Nanotechnology Contributing to the Super Smart Society”

Each year nano tech holds Special Symposium, in which industry specialists from top organizations from Japan and abroad speak about the issues surrounding the latest trends in nanotech. The themes of this year’s Symposium are Life Nanotechnology, Graphene, AI/IoT, Cellulose Nanofibers, and Materials Informatics.

Notable sessions include:

Life Nanotechnology
“Development of microRNA liquid biopsy for early detection of cancer”
Takahiro Ochiya, National Cancer Center Research Institute Division of Molecular and Cellular Medicine, Chief

AI / IoT
“AI Embedded in the Real World”
Hideki Asoh, AIST Deputy Director, Artificial Intelligence Research Center

Cellulose Nanofibers [emphasis mine]
“The Current Trends and Challenges for Industrialization of Nanocellulose”
Satoshi Hirata, Nanocellulose Forum Secretary-General

Materials Informatics
“Perspective of Materials Research”
Hideo Hosono, Tokyo Institute of Technology Professor

View the full list of sessions:
>> http://nanotech2017.icsbizmatch.jp/Presentation/en/Info/List#main_theater

nano tech 2017 Homepage:
>> http://nanotechexpo.jp/

nano tech 2017, the 16th International Nanotechnology Exhibition & Conference
Date: February 15-17, 2017, 10:00-17:00
Venue: Tokyo Big Sight (East Halls 4-6 & Conference Tower)
Organizer: nano tech Executive Committee, JTB Communication Design

As you may have guessed the Alberta information can be found in the .Cellulose Nanofibers session. From the conference/seminar program page; scroll down about 25% of the way to find the Alberta presentation,

Production and Applications Development of Cellulose Nanocrystals (CNC) at InnoTech Alberta

Behzad (Benji) Ahvazi
InnoTech Alberta Team Lead, Cellulose Nanocrystals (CNC)

[ Abstract ]

The production and use of cellulose nanocrystals (CNC) is an emerging technology that has gained considerable interest from a range of industries that are working towards increased use of “green” biobased materials. The construction of one-of-a-kind CNC pilot plant [emphasis mine] at InnoTech Alberta and production of CNC samples represents a critical step for introducing the cellulosic based biomaterials to industrial markets and provides a platform for the development of novel high value and high volume applications. Major key components including feedstock, acid hydrolysis formulation, purification, and drying processes were optimized significantly to reduce the operation cost. Fully characterized CNC samples were provided to a large number of academic and research laboratories including various industries domestically and internationally for applications development.

[ Profile ]

Dr. Ahvazi completed his Bachelor of Science in Honours program at the Department of Chemistry and Biochemistry and graduated with distinction at Concordia University in Montréal, Québec. His Ph.D. program was completed in 1998 at McGill Pulp and Paper Research Centre in the area of macromolecules with solid background in Lignocellulosic, organic wood chemistry as well as pulping and paper technology. After completing his post-doctoral fellowship, he joined FPInnovations formally [formerly?] known as PAPRICAN as a research scientist (R&D) focusing on a number of confidential chemical pulping and bleaching projects. In 2006, he worked at Tembec as a senior research scientist and as a Leader in Alcohol and Lignin (R&D). In April 2009, he held a position as a Research Officer in both National Bioproducts (NBP1 & NBP2) and Industrial Biomaterials Flagship programs at National Research Council Canada (NRC). During his tenure, he had directed and performed innovative R&D activities within both programs on extraction, modification, and characterization of biomass as well as polymer synthesis and formulation for industrial applications. Currently, he is working at InnoTech Alberta as Team Lead for Biomass Conversion and Processing Technologies.

Canada scene update

InnoTech Alberta was until Nov. 1, 2016 known as Alberta Innovates – Technology Futures. Here’s more about InnoTech Alberta from the Alberta Innovates … home page,

Effective November 1, 2016, Alberta Innovates – Technology Futures is one of four corporations now consolidated into Alberta Innovates and a wholly owned subsidiary called InnoTech Alberta.

You will find all the existing programs, services and information offered by InnoTech Alberta on this website. To access the basic research funding and commercialization programs previously offered by Alberta Innovates – Technology Futures, explore here. For more information on Alberta Innovates, visit the new Alberta Innovates website.

As for InnoTech Alberta’s “one-of-a-kind CNC pilot plant,” I’d like to know more about it’s one-of-a-kind status since there are two other CNC production plants in Canada. (Is the status a consequence of regional chauvinism or a writer unfamiliar with the topic?). Getting back to the topic, the largest company (and I believe the first) with a CNC plant was CelluForce, which started as a joint venture between Domtar and FPInnovations and powered with some very heavy investment from the government of Canada. (See my July 16, 2010 posting about the construction of the plant in Quebec and my June 6, 2011 posting about the newly named CelluForce.) Interestingly, CelluForce will have a booth at nano tech 2017 (according to its Jan. 27, 2017 news release) although the company doesn’t seem to have any presentations on the schedule. The other Canadian company is Blue Goose Biorefineries in Saskatchewan. Here’s more about Blue Goose from the company website’s home page,

Blue Goose Biorefineries Inc. (Blue Goose) is pleased to introduce our R3TM process. R3TM technology incorporates green chemistry to fractionate renewable plant biomass into high value products.

Traditionally, separating lignocellulosic biomass required high temperatures, harsh chemicals, and complicated processes. R3TM breaks this costly compromise to yield high quality cellulose, lignin and hemicellulose products.

The robust and environmentally friendly R3TM technology has numerous applications. Our current product focus is cellulose nanocrystals (CNC). Cellulose nanocrystals are “Mother Nature’s Building Blocks” possessing unique properties. These unique properties encourage the design of innovative products from a safe, inherently renewable, sustainable, and carbon neutral resource.

Blue Goose assists companies and research groups in the development of applications for CNC, by offering CNC for sale without Intellectual Property restrictions. [emphasis mine]

Bravo to Blue Goose! Unfortunately, I was not able to determine if the company will be at nano tech 2017.

One final comment, there was some excitement about CNC a while back where I had more than one person contact me asking for information about how to buy CNC. I wasn’t able to be helpful because there was, apparently, an attempt by producers to control sales and limit CNC access to a select few for competitive advantage. Coincidentally or not, CelluForce developed a stockpile which has persisted for some years as I noted in my Aug. 17, 2016 posting (scroll down about 70% of the way) where the company announced amongst other events that it expected deplete its stockpile by mid-2017.

The State of Science and Technology (S&T) and Industrial Research and Development (IR&D) in Canada

Earlier this year I featured (in a July 1, 2016 posting) the announcement of a third assessment of science and technology in Canada by the Council of Canadian Academies. At the time I speculated as to the size of the ‘expert panel’ making the assessment as they had rolled a second assessment (Industrial Research and Development) into this one on the state of science and technology. I now have my answer thanks to an Oct. 17, 2016 Council of Canadian Academies news release announcing the chairperson (received via email; Note: Links have been removed and emphases added for greater readability),

The Council of Canadian Academies (CCA) is pleased to announce Dr. Max Blouw, President and Vice-Chancellor of Wilfrid Laurier University, as Chair of the newly appointed Expert Panel on the State of Science and Technology (S&T) and Industrial Research and Development (IR&D) in Canada.

“Dr. Blouw is a widely respected leader with a strong background in research and academia,” said Eric M. Meslin, PhD, FCAHS, President and CEO of the CCA. “I am delighted he has agreed to serve as Chair for an assessment that will contribute to the current policy discussion in Canada.”

As Chair of the Expert Panel, Dr. Blouw will work with the multidisciplinary, multi-sectoral Expert Panel to address the following assessment question, referred to the CCA by Innovation, Science and Economic Development Canada (ISED):

What is the current state of science and technology and industrial research and development in Canada?

Dr. Blouw will lead the CCA Expert Panel to assess the available evidence and deliver its final report by late 2017. Members of the panel include experts from different fields of academic research, R&D, innovation, and research administration. The depth of the Panel’s experience and expertise, paired with the CCA’s rigorous assessment methodology, will ensure the most authoritative, credible, and independent response to the question.

“I am very pleased to accept the position of Chair for this assessment and I consider myself privileged to be working with such an eminent group of experts,” said Dr. Blouw. “The CCA’s previous reports on S&T and IR&D provided crucial insights into Canada’s strengths and weaknesses in these areas. I look forward to contributing to this important set of reports with new evidence and trends.”

Dr. Blouw was Vice-President Research, Associate Vice-President Research, and Professor of Biology, at the University of Northern British Columbia, before joining Wilfrid Laurier as President. Dr. Blouw served two terms as the chair of the university advisory group to Industry Canada and was a member of the adjudication panel for the Ontario Premier’s Discovery Awards, which recognize the province’s finest senior researchers. He recently chaired the International Review Committee of the NSERC Discovery Grants Program.

For a complete list of Expert Panel members, their biographies, and details on the assessment, please visit the assessment page. The CCA’s Member Academies – the Royal Society of Canada, the Canadian Academy of Engineering, and the Canadian Academy of Health Sciences – are a key source of membership for expert panels. Many experts are also Fellows of the Academies.

The Expert Panel on the State of S&T and IR&D
Max Blouw, (Chair) President and Vice-Chancellor of Wilfrid Laurier University
Luis Barreto, President, Dr. Luis Barreto & Associates and Special Advisor, NEOMED-LABS
Catherine Beaudry, Professor, Department of Mathematical and Industrial Engineering, Polytechnique Montréal
Donald Brooks, FCAHS, Professor, Pathology and Laboratory Medicine, and Chemistry, University of British Columbia
Madeleine Jean, General Manager, Prompt
Philip Jessop, FRSC, Professor, Inorganic Chemistry and Canada Research Chair in Green Chemistry, Department of Chemistry, Queen’s University; Technical Director, GreenCentre Canada
Claude Lajeunesse, FCAE, Corporate Director and Interim Chair of the Board of Directors, Atomic Energy of Canada Ltd.
Steve Liang, Associate Professor, Geomatics Engineering, University of Calgary; Director, GeoSensorWeb Laboratory; CEO, SensorUp Inc.
Robert Luke, Vice-President, Research and Innovation, OCAD University
Douglas Peers, Professor, Dean of Arts, Department of History, University of Waterloo
John M. Thompson, O.C., FCAE, Retired Executive Vice-Chairman, IBM Corporation
Anne Whitelaw, Associate Dean Research, Faculty of Fine Arts and Associate Professor, Department of Art History, Concordia University
David A. Wolfe, Professor, Political Science and Co-Director, Innovation Policy Lab, Munk School of Global Affairs, University of Toronto

You can find more information about the expert panel here and about this assessment and its predecesors here.

A few observations, given the size of the task this panel is lean. As well, there are three women in a group of 13 (less than 25% representation) in 2016? It’s Ontario and Québec-dominant; only BC and Alberta rate a representative on the panel. I hope they will find ways to better balance this panel and communicate that ‘balanced story’ to the rest of us. On the plus side, the panel has representatives from the humanities, arts, and industry in addition to the expected representatives from the sciences.

Combat cells (Robot Wars for cells) and a plea from Concordia University

Students at Concordia University (located in Montréal, Québec, Canada) are requesting help (financial or laboratory supplies) for their submission to  the 2016 iGEM (International Genetically Engineered Machine) competition.

Here’s a little about their entry (from a June 16, 2016 request received via email),

For this year’s project, we plan to design a biological system that mimics the concept of the popular TV series Robot Wars. We will be engineering cellular species to wear nanoparticles as battle shields and then use microfluidics to guide them through an obstacle course leading to a battledome, where both cells will engage into a duel. Essentially, we want to test the interactions between nanoparticles and cell membranes, as well as their protective abilities against varying environmental conditions and other equipped cells. The method in which we will adapt Robot Wars for synthetic biology is by creating a web series that will visualize the cell battle and communicate the research behind it. This web series will serve as an entertaining  medium to educate and inspire the audience to develop an interest in science. We are incorporating the emerging fields of  synthetic biology, nanotechnology and microfluidics to make this process possible.  Furthermore, this study will contribute to the advancement of nanotechnology, an interdisciplinary field aiming to make applicable improvements in other fields such as medicine, optics and cosmetics.

Here’s a little more about iGEM (from the organization’s homepage),

The iGEM Foundation is dedicated to education and competition, advancement of synthetic biology, and the development of open community and collaboration.

The main program at the iGEM Foundation is the International Genetically Engineered Machine (iGEM) Competition. The iGEM Competition is the premiere student competition in Synthetic Biology. Since 2004, participants of the competition have experienced education, teamwork, sharing, and more in a unique competition setting.

The deadline for donations/sponsorships is the end of September 2016 and sponsors/donors will be acknowledged on “our website, all of our social media accounts (Facebook, Instagram, Twitter), at our community outreach events and at the competition [from the June 16, 2016 email].”

For more information contact:

Maria Salouros
iGEM Concordia
igem.concordia@gmail.com

Finally, there’s this:

We are excited to make this year’s project a reality and we are determined to win gold. Any help, either financially or by the donation of laboratory supplies, would contribute to the development of our project and would be greatly appreciated.

Good luck to the students! Hopefully one or more of my readers will be able to help. In which case, thank you!

A dress that lights up according to reactions on Twitter

I don’t usually have an opportunity to write about red carpet events but the recent Met Gala, also known as the Costume Institute Gala and the Met Ball, which took place on the evening of May 2, 2016 in New York, featured a ‘cognitive’ dress. Here’s more from a May 2, 2016 article by Emma Spedding for The Telegraph (UK),

“Tech white tie” was the dress code for last night’s Met Gala, inspired by the theme of this year’s Met fashion exhibition, ‘Manus x Machina: Fashion in the Age of Technology’. While many of the a-list attendees interpreted this to mean ‘silver sequins’, several rose to the challenge with beautiful, future-gazing gowns which give a glimpse of how our clothes might behave in the future.

Supermodel Karolina Kurkova wore a ‘cognitive’ Marchesa gown that was created in collaboration with technology company IBM. The two companies came together following a survey conducted by IBM which found that Marchesa was one of the favourite designers of its employees. The dress is created using a conductive fabric chosen from 40,000 options and embedded with 150 LED lights which change colour in reaction to the sentiments of Kurkova’s Twitter followers.

A May 2, 2016 article by Rose Pastore for Fast Company provides a little more technical detail and some insight into why Marchesa partnered with IBM,

At the Met Gala in Manhattan tonight [May 2, 2016], one model will be wearing a “cognitive dress”: A gown, designed by fashion house Marchesa, that will shift in color based on input from IBM’s Watson supercomputer. The dress features gauzy white roses, each embedded with an LED that will display different colors depending on the general sentiment of tweets about the Met Gala. The algorithm powering the dress relies on Watson Color Theory, which links emotions to colors, and on the Watson Tone Analyzer, a service that can detect emotion in text.

In addition to the color-changing cognitive dress, Marchesa designers are using Watson to get new color palette ideas. The designers choose from a list of emotions and concepts—things like romance, excitement, and power—and Watson recommends a palette of colors it associates with those sentiments.

An April 29, 2016 posting by Ann Rubin for IBM’s Think blog discusses the history of technology/art partnerships and provides more technical detail (yes!) about this one,

Throughout history, we’ve seen traces of technology enabling humans to create – from Da Vinci’s use of the camera obscura to Caravaggio’s work with mirrors and lenses. Today, cognitive systems like Watson are giving artists, designers and creative minds the tools to make sense of the world in ground-breaking ways, opening up new avenues for humans to approach creative thinking.

The dress’ cognitive creation relies on a mix of Watson APIs, cognitive tools from IBM Research, solutions from Watson developer partner Inno360 and the creative vision from the Marchesa design team. In advance of it making its exciting debut on the red carpet, we’d like to take you on the journey of how man and machine collaborated to create this special dress.

Rooted in the belief that color and images can indicate moods and send messages, Marchesa first selected five key human emotions – joy, passion, excitement, encouragement and curiosity – that they wanted the dress to convey. IBM Research then fed this data into the cognitive color design tool, a groundbreaking project out of IBM Research-Yorktown that understands the psychological effects of colors, the interrelationships between emotions, and image aesthetics.

This process also involved feeding Watson hundreds of images associated with Marchesa dresses in order to understand and learn the brand’s color palette. Ultimately, Watson was able to suggest color palettes that were in line with Marchesa’s brand and the identified emotions, which will come to life on the dress during the Met Gala.

Once the colors were finalized, Marchesa turned to IBM partner Inno360 to source a fabric for their creation. Using Inno360’s R&D platform – powered by a combination of seven Watson services – the team searched more than 40,000 sources for fabric information, narrowing down to 150 sources of the most useful options to consider for the dress.

From this selection, Inno360 worked in partnership with IBM Research-Almaden to identify printed and woven textiles that would respond well to the LED technology needed to execute the final part of the collaboration. Inno360 was then able to deliver 35 unique fabric recommendations based on a variety of criteria important to Marchesa, like weight, luminosity, and flexibility. From there, Marchesa weighed the benefits of different material compositions, weights and qualities to select the final fabric that suited the criteria for their dress and remained true to their brand.

Here’s what the dress looks like,

Courtesy of Marchesa Facebook page {https://www.facebook.com/MarchesaFashion/)

Courtesy of Marchesa Facebook page {https://www.facebook.com/MarchesaFashion/)

Watson is an artificial intelligence program,which I have written about a few times but I think this Feb. 28, 2011 posting (scroll down about 50% of the way), which mentions Watson, product placement, Jeopardy (tv quiz show), and medical diagnoses seems the most à propos given IBM’s latest product placement at the Met Gala.

Not the only ‘tech’ dress

There was at least one other ‘tech’ dress at the 2016 Met Gala, this one designed by Zac Posen and worn by Claire Danes. It did not receive a stellar review in a May 3, 2016 posting by Elaine Lui on Laineygossip.com,

People are losing their goddamn minds over this dress, by Zac Posen. Because it lights up.

It’s bullsh-t.

This is a BULLSH-T DRESS.

It’s Cinderella with a lamp shoved underneath her skirt.

Here’s a video of Danes and her dress at the Met Gala,

A Sept. 10, 2015 news item in People magazine indicates that Posen’s a different version of a ‘tech’ dress was a collaboration with Google (Note: Links have been removed),

Designer Zac Posen lit up his 2015 New York Fashion Week kickoff show on Tuesday by debuting a gorgeous and tech-savvy coded LED dress that blinked in different, dazzling pre-programmed patterns down the runway.

In coordination with Google’s non-profit organization, Made with Code, which inspires girls to pursue careers in tech coding, Posen teamed up with 30 girls (all between the ages of 13 and 18), who attended the show, to introduce the flashy dress — which was designed by Posen and coded by the young women.

“This is the future of the industry: mixing craft, fashion and technology,” the 34-year-old designer told PEOPLE. “There’s a discrepancy in the coding field, hardly any women are at the forefront, and that’s a real shame. If we can entice young women through the allure of fashion, to get them learning this language, why not?”

..

Through a micro controller, the gown displays coded patterns in 500 LED lights that are set to match the blues and yellows of Posen’s new collection. The circuit was designed and physically built into Posen’s dress fabric by 22-year-old up-and-coming fashion designer and computer science enthusiast, Maddy Maxey, who tells PEOPLE she was nervous watching Rocha [model Coco Rocha] make her way down the catwalk.

“It’s exactly as if she was carrying a microwave down the runway,” Maxey said. “It’s an entire circuit on a textile, so if one connection had come lose, the dress wouldn’t have worked. But, it did! And it was so deeply rewarding.”

Other ‘tech’ dresses

Back in 2009 I attended that year’s International Symposium on Electronic Arts and heard Clive van Heerden of Royal Philips Electronics talk about a number of innovative concepts including a ‘mood’ dress that would reveal the wearer’s emotions to whomever should glance their way. It was not a popular concept especially not in Japan where it was first tested.

The symposium also featured Maurits Waldemeyer who worked with fashion designer Chalayan Hussein and LED dresses and dresses that changed shape as the models went down the runway.

In 2010 there was a flurry of media interest in mood changing ‘smart’ clothes designed by researchers at Concordia University (Barbara Layne, Canada) and Goldsmiths College (Janis Jefferies, UK). Here’s more from a June 4, 2010 BBC news online item,

The clothes are connected to a database that analyses the data to work out a person’s emotional state.

Media, including songs, words and images, are then piped to the display and speakers in the clothes to calm a wearer or offer support.

Created as part of an artistic project called Wearable Absence the clothes are made from textiles woven with different sorts of wireless sensors. These can track a wide variety of tell-tale biological markers including temperature, heart rate, breathing and galvanic skin response.

Final comments

I don’t have anything grand to say. It is interesting to see the progression of ‘tech’ dresses from avant garde designers and academics to haute couture.

Chemicals that slow biological aging in yeast might help humans too

A March 15, 2016 Concordia University (Montréal, Canada) news release (also on EurekAlert) describes research that may slow the aging process (Note: Links have been removed),

Even though the search for the Fountain of Youth dates back to the ancient Greeks, the quest to live forever continues today. Indeed, it has been said that the ability to slow the aging process would be the most important medical discovery in the modern era.

A new study published in the journal Oncotarget by researchers from Concordia and the Quebec-based biotech company Idunn Technologies may have uncovered an important factor: plant extracts containing the six best groups of anti-aging molecules ever seen.

For the study, the research team combed through Idunn Technologies’ extensive biological library, conducting more than 10,000 trials to screen for plant extracts that would increase the chronological lifespan of yeast.

Why yeast? Cellularly speaking, aging progresses similarly in both yeast and humans. It’s the best cellular model to understand how the anti-aging process takes place.

“In total, we found six new groups of molecules that decelerate the chronological aging of yeast,” says Vladimir Titorenko, the study’s senior author and a professor in the Department of Biology at Concordia. He carried out the study with a group of Concordia students and Éric Simard, the founder of Idunn Technologies, which is named for the goddess of rejuvenation in Norse mythology.

This has important implications not only for slowing the aging process, but also for preventing certain diseases associated with aging, including cancer.

“Rather than focus on curing the individual disease, interventions on the molecular processes of aging can simultaneously delay the onset and progression of most age-related disorders. This kind of intervention is predicted to have a much larger effect on healthy aging and life expectancy than can be attained by treating individual diseases,” says Simard, who notes that these new molecules will soon be available in commercial products.

“These results also provide new insights into mechanisms through which chemicals extracted from certain plants can slow biological aging,” says Titorenko.

One of these groups of molecules is the most potent longevity-extending pharmacological intervention yet described in scientific literature: a specific extract of willow bark.

Willow bark was commonly used during the time of Hippocrates, when people were advised to chew on it to relieve pain and fever. The study showed that it increases the average and maximum chronological lifespan of yeast by 475 per cent and 369 per cent, respectively. This represents a much greater effect than rapamycin and metformin, the two best drugs known for their anti-aging effects.

“These six extracts have been recognized as non-toxic by Health Canada, and already exhibit recognized health benefits in humans,” says Simard.

“But first, more research must be done. That’s why Idunn Technologies is collaborating with four other universities for six research programs, to go beyond yeast, and work with an animal model of aging, as well as two cancer models.”

A rather interesting image was included with the news release,

The Fountain of Youth, a 1546 painting by Lucas Cranach the Elder. Courtesy: Concordia University

The Fountain of Youth, a 1546 painting by Lucas Cranach the Elder. Courtesy: Concordia University

There’s also this,

An extract of willow bark has shown to be one of the most potent longevity-extending pharmacological interventions yet described in scientific literature. Courtesy: Concordia University

An extract of willow bark has shown to be one of the most potent longevity-extending pharmacological interventions yet described in scientific literature. Courtesy: Concordia University

Here’s a link to and a citation for the paper,

Discovery of plant extracts that greatly delay yeast chronological aging and have different effects on longevity-defining cellular processes by Vicky Lutchman, Younes Medkour, Eugenie Samson, Anthony Arlia-Ciommo, Pamela Dakik, Berly Cortes, Rachel Feldman, Sadaf Mohtashami, Mélissa McAuley, Marisa Chancharoen, Belise Rukundo, Éric Simard, Vladimir I. Titorenko. DOI: 10.18632/oncotarget.7665 Published: February 24, 2016

This appears to be an open access paper.

You can find out more about Idunn Technologies here but you will need French language reading skills as the English language version of the site is not yet available.

Synthetic Aesthetics update and an informal Canadian synthetic biology roundup

Amanda Ruggeri has written a very good introduction to synthetic biology for nonexperts in her May 20, 2015 Globe and Mail article about ‘Designing for the Sixth Extinction’, an exhibit showcasing designs and thought experiments focused on synthetic biology ,

In a corner of Istanbul’s Design Biennial late last year [2014], photographs of bizarre creatures sat alongside more conventional displays of product design and typefaces. Diaphanous globes, like transparent balloons, clung to the mossy trunk of an oak tree. Rust-coloured patterns ran across green leaves, as if the foliage had been decorated with henna. On the forest floor, a slug-like creature slithered, its back dotted with gold markings; in another photograph, what looked like a porcupine without a head crawled over the dirt, its quills tipped blood-red.

But as strange as the creatures looked, what they actually are is even stranger. Not quite living things, not quite machines, these imagined prototypes inhabit a dystopic, future world – a world in which they had been created to solve the problems of the living. The porcupine, for example, is an Autonomous Seed Disperser, described as a device that would collect and disperse seeds to increase biodiversity. The slug would be programmed to seek out acidic soils and neutralize them by dispersing an alkali hygroscopic fluid.

They are the designs – and thought experiments – of London-based Alexandra Daisy Ginsberg, designer, artist and lead author of the book Synthetic Aesthetics: Investigating Synthetic Biology’s Designs on Nature. In her project Designing for the Sixth Extinction, which after Istanbul is now on display at the Design Museum in London, Ginsberg imagines what a synthetic biology-designed world would look like – and whether it’s desirable. “

I have a couple of comments. First, the ‘Synthetic Aesthetics: Investigating Synthetic Biology’s Designs on Nature’ book launch last year was covered here in a May 5, 2014 post. where you’ll notice a number of the academics included in Ruggeri’s article are contributors to the book (but not mentioned as such). Second, I cannot find ‘Design for the Sixth Extinction’ listed as an exhibition on London’s Design Museum website.

Getting back to the matter at hand, not all of the projects mentioned in Ruggeri’s article are ‘art’ projects, there is also this rather practical and controversial initiative,

Designing even more complex organisms is the inevitable, and controversial, next step. And those designs have already begun. The British company Oxitec has designed a sterile male mosquito. When the bugs are released into nature and mate, no offspring result, reducing the population or eliminating it altogether. This could be a solution to dengue fever, a mosquito-carried disease that infects more than 50 million people each year: In field trials in Cayman, Panama and Brazil, the wild population of the dengue-carrying mosquito species was reduced by 90 per cent. Yet, as a genetically engineered solution, it also makes some skittish. The consequences of such manipulations remain unforeseen, they say. Proponents counter that the solution is more elegant, and safer, than the current practice of spraying chemicals.

Even so, the engineered mosquito leads to overarching questions: What are the dangers of tinkering with life? Could this cause a slide toward eugenics? Currently, the field doesn’t have an established ethics oversight process, something some critics are pushing to change.

It’s a surprising piece for the Globe and Mail newspaper to run since it doesn’t have a Canadian angle to it and the Globe and Mail doesn’t specialize in science (not withstanding Ivan Semeniuk’s science articles) or art/science or synthetic biology writing, for that matter. Perhaps it bodes an interest and more pieces on emerging science and technology and on art/science projects?

In any event, it seems like a good time to review some of the synthetic biology work or the centres of activity in Canada.  I believe the last time I tackled this particular topic was in a May 24, 2010 post titled, Canada and synthetic biology in the wake of the first ‘synthetic’ bacteria.

After a brief search, I found three centres for research:

Concordia [University] Centre for Applied Synthetic Biology (CASB)

[University of Toronto] The Synthetic Biology and Cellular Control Lab

[University of British Columbia] Centre for High-Throughput Biology (CHiBi)

Following an Oct. 27 – 28, 2014 UK-Canada Synthetic Biology Workshop held at Concordia University, Rémi Quirion, Vincent Martin, Pierre Meulien and Marc LePage co-wrote a Nov. 4, 2014 Concordia University post titled, How Canada is poised to revolutionize synthetic biology,

Rémi Quirion is the Chief Scientist of Québec, Fonds de recherche du Québec. Vincent Martin is Canada Research Chair in Microbial Genomics and Engineering and a professor in the Department of Biology at Concordia University in Montreal. Pierre Meulien is President and CEO of Genome Canada. Marc LePage is the President and CEO of Génome Québec.

Canada’s research and business communities have an opportunity to become world leaders in a burgeoning field that is fast shaping how we deal with everything from climate change to global food security and the production of lifesaving medications. The science of synthetic biology has the transformative capacity to equip us with novel technology tools and products to build a more sustainable society, while creating new business and employment opportunities for the economy of tomorrow.

We can now decipher the code of life for any organism faster and less expensively than ever before. Canadian scientists are producing anti-malarial drugs from organic materials that increase the availability and decrease the cost of lifesaving medicines. They are also developing energy efficient biofuels to dramatically reduce environmental and manufacturing costs, helping Canadian industry to thrive in the global marketplace.

The groundwork has also been laid for a Canadian revolution in the field. Canada’s scientific community is internationally recognized for its leadership in genomics research and strong partnerships with key industries. Since 2000, Genome Canada and partners have invested more than $2.3 billion in deciphering the genomes of economically important plants, animals and microbes in order to understand how they function. A significant proportion of these funds has been invested in building the technological toolkits that can be applied to synthetic biology.

But science cannot do it alone. Innovation on this scale requires multiple forms of expertise in order to be successful. Research in law, business, social sciences and humanities is vital to addressing questions of ethics, supply chain management, social innovation and cultural adaptation to new technologies. Industry knowledge and investments, as well as the capacity to incentivize entrepreneurship, are key to devising business models that will enable new products to thrive. Governments and funding agencies also need to do their part by supporting multidisciplinary research, training and infrastructure.

It’s a bit ‘hype happy’ for my taste but it does provide some fascinating insight in what seems to be a male activity in Canada.

Counterbalancing that impression is an Oct. 6, 2013 article by Ivan Semeniuk for the Globe and Mail about a University of Lethbridge team winning the top prize in a synthetic biology contest,

If you want to succeed in the scientific revolution of the future, it helps to think about life as a computer program.

That strategy helped University of Lethbridge students walk away with the top prize in a synthetic biology competition Sunday. Often touted as the genetic equivalent of the personal computer revolution, synthetic biology involves thinking about cells as programmable machines that can be designed and built to suit a particular need – whether it’s mass producing a vaccine or breaking down a hazardous chemical in the environment.

The five member Lethbridge team came up with a way to modify how cells translate genetic information into proteins. Rather than one bit of DNA carrying the information to make one protein – the usual way cells go about their business – the method involves inserting a genetic command that jiggles a cell’s translational machinery while it’s in mid-operation, coaxing it to produce two proteins out of the same DNA input.

“We started off with a computer analogy – kind of like zipping your files together – so you’d zip two protein sequences together and therefore save space,” said Jenna Friedt, a graduate student in biochemistry at Lethbridge. [emphasis mine]

There are concerns other than gender issues, chief amongst them, ethics. The Canadian Biotechnology Action Network maintains an information page on Synthetic Biology which boasts this as its latest update,

October 2014: In a unanimous decision of 194 countries, the United Nation’s Convention on Biological Diversity formally urged countries to regulate synthetic biology, a new extreme form of genetic engineering. The landmark decision follows ten days of hard-fought negotiations between developing countries and a small group of wealthy biotech-friendly economies. Until now, synthetic organisms have been developed and commercialized without international regulations. …

Finally, there’s a June 2014 synthetic biology timeline from the University of Ottawa’s Institute for Science, Society, and Policy (ISSP) which contextualizes Canadian research, policy and regulation with Australia, the European Union, the UK, and the US.

(On a closely related note, there’s my May 14, 2015 post about genetic engineering and newly raised concerns.)

US White House establishes new initiatives to commercialize nanotechnology

As I’ve noted several times, there’s a strong push in the US to commercialize nanotechnology and May 20, 2015 was a banner day for the efforts. The US White House announced a series of new initiatives to speed commercialization efforts in a May 20, 2015 posting by Lloyd Whitman, Tom Kalil, and JJ Raynor,

Today, May 20 [2015], the National Economic Council and the Office of Science and Technology Policy held a forum at the White House to discuss opportunities to accelerate the commercialization of nanotechnology.

In recognition of the importance of nanotechnology R&D, representatives from companies, government agencies, colleges and universities, and non-profits are announcing a series of new and expanded public and private initiatives that complement the Administration’s efforts to accelerate the commercialization of nanotechnology and expand the nanotechnology workforce:

  • The Colleges of Nanoscale Science and Engineering at SUNY Polytechnic Institute in Albany, NY and the National Institute for Occupational Safety and Health are launching the Nano Health & Safety Consortium to advance research and guidance for occupational safety and health in the nanoelectronics and other nanomanufacturing industry settings.
  • Raytheon has brought together a group of representatives from the defense industry and the Department of Defense to identify collaborative opportunities to advance nanotechnology product development, manufacturing, and supply-chain support with a goal of helping the U.S. optimize development, foster innovation, and take more rapid advantage of new commercial nanotechnologies.
  • BASF Corporation is taking a new approach to finding solutions to nanomanufacturing challenges. In March, BASF launched a prize-based “NanoChallenge” designed to drive new levels of collaborative innovation in nanotechnology while connecting with potential partners to co-create solutions that address industry challenges.
  • OCSiAl is expanding the eligibility of its “iNanoComm” matching grant program that provides low-cost, single-walled carbon nanotubes to include more exploratory research proposals, especially proposals for projects that could result in the creation of startups and technology transfers.
  • The NanoBusiness Commercialization Association (NanoBCA) is partnering with Venture for America and working with the National Science Foundation (NSF) to promote entrepreneurship in nanotechnology.  Three companies (PEN, NanoMech, and SouthWest NanoTechnologies), are offering to support NSF’s Innovation Corps (I-Corps) program with mentorship for entrepreneurs-in-training and, along with three other companies (NanoViricides, mPhase Technologies, and Eikos), will partner with Venture for America to hire recent graduates into nanotechnology jobs, thereby strengthening new nanotech businesses while providing needed experience for future entrepreneurs.
  • TechConnect is establishing a Nano and Emerging Technologies Student Leaders Conference to bring together the leaders of nanotechnology student groups from across the country. The conference will highlight undergraduate research and connect students with venture capitalists, entrepreneurs, and industry leaders.  Five universities have already committed to participating, led by the University of Virginia Nano and Emerging Technologies Club.
  • Brewer Science, through its Global Intern Program, is providing more than 30 students from high schools, colleges, and graduate schools across the country with hands-on experience in a wide range of functions within the company.  Brewer Science plans to increase the number of its science and engineering interns by 50% next year and has committed to sharing best practices with other nanotechnology businesses interested in how internship programs can contribute to a small company’s success.
  • The National Institute of Standards and Technology’s Center for Nanoscale Science and Technology is expanding its partnership with the National Science Foundation to provide hands-on experience for students in NSF’s Advanced Technology Education program. The partnership will now run year-round and will include opportunities for students at Hudson Valley Community College and the University of the District of Columbia Community College.
  • Federal agencies participating in the NNI [US National Nanotechnology Initiative], supported by the National Nanotechnology Coordination Office [NNCO], are launching multiple new activities aimed at educating students and the public about nanotechnology, including image and video contests highlighting student research, a new webinar series focused on providing nanotechnology information for K-12 teachers, and a searchable web portal on nano.gov of nanoscale science and engineering resources for teachers and professors.

Interestingly, May 20, 2015 is also the day the NNCO held its second webinar for small- and medium-size businesses in the nanotechnology community. You can find out more about that webinar and future ones by following the links in my May 13, 2015 posting.

Since the US White House announcement, OCSiAl has issued a May 26, 2015 news release which provides a brief history and more details about its newly expanded NanoComm program,

OCSiAl launched the iNanoComm, which stands for the Integrated Nanotube Commercialization Award, program in February 2015 to help researchers lower the cost of their most promising R&D projects dedicated to SWCNT [single-walled carbon nanotube] applications. The first round received 33 applications from 28 university groups, including The Smalley-Curl Center for Nanoscale Science and Technology at Rice University and the Concordia Center for Composites at Concordia University [Canada] among others. [emphasis mine] The aim of iNanoComm is to stimulate universities and research organizations to develop innovative market products based on nano-augmented materials, also known as clean materials.

Now the program’s criteria are being broadened to enable greater private sector engagement in potential projects and the creation of partnerships in commercializing nanotechnology. The program will now support early stage commercialization efforts connected to university research in the form of start-ups, technology transfers, new businesses and university spinoffs to support the mass commercialization of SWCNT products and technologies.

The announcement of the program’s expansion took place at the 2015 Roundtable of the US NanoBusiness Commercialization Association (NanoBCA), the world’s first non-profit association focused on the commercialization of nanotechnologies. NanoBCA is dedicated to creating an environment that nurtures research and innovation in nanotechnology, promotes tech-transfer of nanotechnology from academia to industry, encourages private capital investments in nanotechnology companies, and helps its corporate members bring innovative nanotechnology products to market.

“Enhancing iNanoComm as a ‘start-up incubator’ is a concrete step in promoting single-wall carbon nanotube applications in the commercial world,” said Max Atanassov, CEO of OCSiAl USA. “It was the logical thing for us to do, now that high quality carbon nanotubes have become broadly available and are affordably priced to be used on a mass industrial scale.”

Vince Caprio, Executive Director of NanoBCA, added that “iNanoComm will make an important contribution to translating fundamental nanotechnology research into commercial products. By facilitating the formation of more start-ups, it will encourage more scientists to pursue their dreams and develop their ideas into commercially successful businesses.”

For more information on the program expansion and how it can reduce the cost of early stage research connected to university projects, visit the iNanoComm website at www.inanocomm.org or contact info@inanocomm.org.

h/t Azonano May 27, 2015 news item