Posts Tagged ‘Cornell University’

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Nanotechnology-enabled fashion at Cornell University

Wednesday, May 8th, 2013

The image you see below is one of several featuring work from Cornell University’s Textiles Nanotechnology Laboratory,

Wearable Charging StationCredit: Textiles Nanotechnology Laboratory/Cornell UniversityAbbey Liebman, a design student at Cornell University in Ithaca, N.Y., created a dress made with conductive cotton that can charge an iPhone via solar panels.

Wearable Charging StationCredit: Textiles Nanotechnology Laboratory/Cornell University. Abbey Liebman, a design student at Cornell University in Ithaca, N.Y., created a dress made with conductive cotton that can charge an iPhone via solar panels.

It’s part of a May 7, 2013 slide show put together by Denise Chow at the LiveScience website. Also shown in the slide show are Olivia Ong’s anti-bacterial clothing (featured here in an Aug. 5, 2011 posting) and some anti-malarial clothing by Matilda Ceesay (featured here in a May 15, 2012 posting). I have more details about the textiles and the work but the pictures on LiveScience are better.

As I’ve not come across LiveScience before ,my curiosity was piqued and to satisfy it, I found this on their About page,

LiveScience, launched in 2004, is the trusted and provocative source for highly accessible science, health and technology news for people who are curious about their minds, bodies, and the world around them. Our team of experienced science reporters, editors and video producers explore the latest discoveries, trends and myths, interviewing expert sources and offering up deep and broad analyses of topics that affect peoples’ lives in meaningful ways. LiveScience articles are regularly featured on the web sites of our media partners: MSNBC.com, Yahoo!, the Christian Science Monitor and others.

Most of the science on LiveScience is ‘bite-sized’ and provides information for people who are busy and/or don’t want much detail.

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Bioengineered ear at Cornell University

Thursday, February 21st, 2013

The researchers claim their bioengineered ear looks and acts like a real ear, from the Feb. 20, 2013 news release on EurekAlert,

Cornell bioengineers and physicians have created an artificial ear – using 3-D printing and injectable molds – that looks and acts like a natural ear, giving new hope to thousands of children born with a congenital deformity called microtia.

In a study published online Feb. 20 in PLOS ONE, Cornell biomedical engineers and Weill Cornell Medical College physicians described how 3-D printing and injectable gels made of living cells can fashion ears that are practically identical to a human ear. Over a three-month period, these flexible ears grew cartilage to replace the collagen that was used to mold them.

“This is such a win-win for both medicine and basic science, demonstrating what we can achieve when we work together,” said co-lead author Lawrence Bonassar, associate professor of biomedical engineering.

The novel ear may be the solution reconstructive surgeons have long wished for to help children born with ear deformity, said co-lead author Dr. Jason Spector, director of the Laboratory for Bioregenerative Medicine and Surgery and associate professor of plastic surgery at Weill Cornell in New York City.

“A bioengineered ear replacement like this would also help individuals who have lost part or all of their external ear in an accident or from cancer,” Spector said.

Replacement ears are usually constructed with materials that have a Styrofoam-like consistency, or sometimes, surgeons build ears from a patient’s harvested rib. This option is challenging and painful for children, and the ears rarely look completely natural or perform well, Spector said.

Lawrence Bonassar, associate professor of biomedical engineering, and colleagues collaborated with Weill Cornell Medical College physicians to create an artificial ear using 3-D printing and injectable molds. Credit: Lindsay France/University Photography [downloaded from http://www.news.cornell.edu/stories/Feb13/earPrint.html]

Lawrence Bonassar, associate professor of biomedical engineering, and colleagues collaborated with Weill Cornell Medical College physicians to create an artificial ear using 3-D printing and injectable molds. Credit: Lindsay France/University Photography [downloaded from http://www.news.cornell.edu/stories/Feb13/earPrint.html]

A Feb. 20, 2013 article in Cornell University’s Chronicle Online (and the basis for the news release) provides details about how this bioengineered ear was achieved (Note: A link has been removed),

To make the ears, Bonassar and colleagues started with a digitized 3-D image of a human subject’s ear and converted the image into a digitized “solid” ear using a 3-D printer to assemble a mold.

They injected the mold with collagen derived from rat tails, and then added 250 million cartilage cells from the ears of cows. This Cornell-developed, high-density gel is similar to the consistency of Jell-O when the mold is removed. The collagen served as a scaffold upon which cartilage could grow.

The process is also fast, Bonassar added: “It takes half a day to design the mold, a day or so to print it, 30 minutes to inject the gel, and we can remove the ear 15 minutes later. We trim the ear and then let it culture for several days in nourishing cell culture media before it is implanted.”

The incidence of microtia, which is when the external ear is not fully developed, varies from almost 1 to more than 4 per 10,000 births each year. Many children born with microtia have an intact inner ear, but experience hearing loss due to the missing external structure.

There was a show in 2004  at the Vancouver Art Gallery (Canada), Massive Change, curated by graphic designer Bruce Mau, which amongst many other objects and images featured a bioengineered nose being grown in a beaker. If memory serves, the work featuring the nose was from Israel and there was no mention of when that work might leave the lab and be used for implants. From the Chronicle article,

Bonassar and Spector have been collaborating on bioengineered human replacement parts since 2007. Bonassar has also worked with Weill Cornell neurological surgeon Dr. Roger Härtl on bioengineered disc replacements using some of the same techniques demonstrated in the PLOS One study.

The researchers specifically work on replacement human structures that are primarily made of cartilage — joints, trachea, spine, nose — because cartilage does not need to be vascularized with a blood supply in order to survive.

They are now looking at ways to expand populations of human ear cartilage cells in the laboratory so that these cells can be used in the mold, instead of cow cartilage.

“Using human cells, specifically those from the same patient, would reduce any possibility of rejection,” Spector said.

He added that the best time to implant a bioengineered ear on a child would be when they are about 5 or 6 years old. At that age, ears are 80 percent of their adult size.

If all future safety and efficacy tests work out, it might be possible to try the first human implant of a Cornell bioengineered ear in as little as three years, Spector said.

Good luck to them. For anyone who’s interested here’s a citation and link to the paper,

Reiffel AJ, Kafka C, Hernandez KA, Popa S, Perez JL, et al. (2013) High-Fidelity Tissue Engineering of Patient-Specific Auricles for Reconstruction of Pediatric Microtia and Other Auricular Deformities. PLoS ONE 8(2): e56506. doi:10.1371/journal.pone.0056506

PLoS One is an open access journal.

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From Cornell University, a liquid that remembers its shape

Tuesday, December 4th, 2012

Sometimes one experiences a frisson (shiver) when reading about a piece of research. Let’s see how you do with this Dec. 4, 2012 news item on Nanowerk,

A bit reminiscent of the Terminator T-1000, a new material created by Cornell researchers is so soft that it can flow like a liquid and then, strangely, return to its original shape.

Rather than liquid metal, it is a hydrogel, a mesh of organic molecules with many small empty spaces that can absorb water like a sponge. It qualifies as a “metamaterial” with properties not found in nature and may be the first organic metamaterial with mechanical meta-properties.

The Dec. 3, 2012 Cornell University news article by Bill Steele, which originated the news item,goes on to explain the interest in hydrogels and what makes this particular formulation so special,

Hydrogels have already been considered for use in drug delivery — the spaces can be filled with drugs that release slowly as the gel biodegrades — and as frameworks for tissue rebuilding. The ability to form a gel into a desired shape further expands the possibilities. For example, a drug-infused gel could be formed to exactly fit the space inside a wound.

…

The new hydrogel is made of synthetic DNA. In addition to being the stuff genes are made of, DNA can serve as a building block for self-assembling materials. Single strands of DNA will lock onto other single stands that have complementary coding, like tiny organic Legos. By synthesizing DNA with carefully arranged complementary sections Luo’s [Dan Luo, professor of biological and environmental engineering] research team previously created short stands that link into shapes such as crosses or Y’s, which in turn join at the ends to form meshlike structures to form the first successful all-DNA hydrogel. Trying a new approach, they mixed synthetic DNA with enzymes that cause DNA to self-replicate and to extend itself into long chains, to make a hydrogel without DNA linkages.

“During this process they entangle, and the entanglement produces a 3-D network,” Luo explained. But the result was not what they expected: The hydrogel they made flows like a liquid, but when placed in water returns to the shape of the container in which it was formed.

“This was not by design,” Luo said.

See the material for yourself,

Hydrogels made in the form of the letters D, N and A collapse into a liquid-like state on their own but return to the original shape when surrounded by water Provided/Luo Lab

Nature Nanotechnology published the team’s research online Dec. 2, 2012 and, unusually, the article is open access (at least for now),

A mechanical metamaterial made from a DNA hydrogel by Jong Bum Lee, Songming Peng, Dayong Yang,  Young Hoon Roh, Hisakage Funabashi, Nokyoung Park, Edward J. Rice, Liwei Chen, Rong Long, Mingming Wu & Dan Luo in Nature Nanotechnology  (2012) doi:10.1038/nnano.2012.211 published online Dec. 2, 2012

Depending on your reading interests and time available, Bill Steele’s Cornell University article has more detail than I’ve provided here or you can check out the well illustrated article in Nature Nanotechnology. As these things go, it’s quite readable as you can see with the abstract (Note: I have removed footnotes),

Metamaterials are artificial substances that are structurally engineered to have properties not typically found in nature. To date, almost all metamaterials have been made from inorganic materials such as silicon and copper, which have unusual electromagnetic or acoustic properties that allow them to be used, for example, as invisible cloaks superlenses or super absorbers for sound. Here, we show that metamaterials with unusual mechanical properties can be prepared using DNA as a building block. We used a polymerase enzyme to elongate DNA chains and weave them non-covalently into a hydrogel. The resulting material, which we term a meta-hydrogel, has liquid-like properties when taken out of water and solid-like properties when in water. Moreover, upon the addition of water, and after complete deformation, the hydrogel can be made to return to its original shape. The meta-hydrogel has a hierarchical internal structure and, as an example of its potential applications, we use it to create an electric circuit that uses water as a switch.

For anyone not familiar with the Terminator movies, here’s an essay in Wikipedia about the ‘franchise’. Pay special note to the second movie in the series, Terminator 2: Judgment Day which introduced a robot (played by Robert Patrick) that could morph from a liquidlike state into various lethal entities.

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Cornell University (New York State, US) celebrates 35 years of nanotechnology research

Monday, July 16th, 2012

The festivities at Cornell University start on July 19, 2012 according to the July 9, 2012 news item by Anne Ju for the Cornell Chronicle,

Photonics, magnetics, biotechnology and energy are just a few areas in which the Cornell NanoScale Science and Technology Facility (CNF) has spent more than three decades connecting the brightest researchers with the best tools and expertise to make their scientific ideas real.

On July 19, CNF will celebrate its storied history of cutting-edge nanoscience research and discovery at its 35th anniversary and annual meeting.

…

Speakers will include Michal Lipson, professor of electrical and computer engineering, who will talk about manipulating light on a chip; and Jordan Katine, of Hitachi Global Storage Technologies and former Cornell postdoctoral associate, who will describe promising methods for making nanoscale magnetic devices.

The event’s keynote speaker will be William Brinkman, director of the Office of Science in the U.S. Department of Energy, who will address “Whither Nanoscience?”

…

Over the years, thanks in part to CNF, Cornell has helped “nanotechnology” become a household word: In 1997, a Cornell student used electron beam lithography to etch a red blood cell-sized guitar onto a silicon chip, a feat that garnered worldwide attention.

Cornell and CNF have stayed on the leading edge of nanoscale science. For example, in the last year, a low-pressure chemical vapor deposition machine for making graphene and carbon nanotubes was purchased through a grant, said Donald Tennant, CNF director of operations.

More than 700 researchers use CNF every year, and about half come from outside Cornell. A key goal of CNF is to have a low-overhead, open-access operating model and to level the playing field for researchers with limited resources, Tennant said.

You can find out more about the July 19, 2012 CNF event here. As for an opening address titled, Whither nanoscience? Doesn’t the word ‘whither’ give the address an old-fashioned flavour, something from the 19th century or perhaps from the bible (Whither thou goest, I will go [Ruth to Naomi])?

Meanwhile, on  July 20, 2012 there will be a special media briefing by Cornell and Stanford University (California) nanoscience researchers, from the July 13, 2012 news item on the Nanotechnology Now website,

On Friday, July 20, from 10 to 11 a.m. [EST], a special panel of nantechnology researchers will gather at Cornell University and explore the future of nanoscience during an interactive conversation with members of the media – both on site in Ithaca and online from anywhere in the world via WebEx technology.

Joining journalists for the discussion will be:

  • Juan Hinestroza, an associate professor fiber science, directs the Textiles Nanotechnology Laboratory at Cornell’s College of Human Ecology. His research on understanding fundamental phenomena at the nanoscale that are relevant to fiber and polymer science, has led to breakthrough “multifunctional fibers” that can hold or change color, conduct and sense micro-electrical currents, and selectively filter toxic gasses.
  •  ….

Media members are invited to take part, in person or online. To do so, please RSVP to John Carberry in Cornell’s Press Relations Office at 607-255-5353 or johncarberry@cornell.edu.

I last mentioned Juan Hinestroza in connection with work done by his students at Cornell University with textiles that give protection from malaria in a May 15, 2012 posting.

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Textiles to offer protection from malaria and more about nanotechnology-enabled textiles

Tuesday, May 15th, 2012

Textiles that harvest our energy to recharge the batteries for phones and other portable devices (for example, US Army research in my May 9, 2012 posting and British soldiers prepare to conduct field tests in my April 5, 2012 posting), that protect us from poison gases (my page on nanotechnology and textiles on the Nanotech Mysteries wiki), that clean pollution from the air (my Feb. 24, 2012 posting about Catalytic Clothing), and more  are currently being developed. It seems textiles used for passive protection and decoration and other forms of personal enhancement (body shapers, ‘lifts and separates’)  are becoming more active. One of the latest developments is a textile that protects from malaria. From the May 8, 2012 news item on Nanowerk,

A Cornell University scientist and designer from Africa have together created a fashionable hooded bodysuit embedded at the molecular level with insecticides for warding off mosquitoes infected with malaria, a disease estimated to kill 655,000 people annually on the continent.

Though insecticide-treated nets are commonly used to drive away mosquitoes from African homes, the Cornell prototype garment can be worn throughout the day to provide extra protection and does not dissipate easily like skin-based repellants. By binding repellant and fabric at the nanolevel using metal organic framework molecules – which are clustered crystalline compounds – the mesh fabric can be loaded with up to three times more insecticide than normal fibrous nets, which usually wear off after about six months.

“The bond on our fabric is very difficult to break,” said Frederick Ochanda, postdoctoral associate in fiber science and apparel design (FSAD) in the College of Human Ecology and a native of Kenya. “The nets in use now are dipped in a solution and not bonded in this way, so their effectiveness doesn’t last very long.”

I’m assuming that this design will be reworked to accommodate more average bodies (from Cornell University’s  ChronicleOnline April 30, 2012 article by Ted Boscia,

Sandy Mattei models a design by Matilda Ceesay '13, an FSAD apparel design major from Gambia, at the Cornell Fashion Collective spring fashion show April 28 on campus. Credit: Mark David Vorreuter

Boscia gives details,

The colorful garment, fashioned by Matilda Ceesay ’13, an FSAD apparel design major from Gambia, debuted at the Cornell Fashion Collective spring fashion show April 28 [2012] on campus. It consists of an underlying one-piece bodysuit, hand-dyed in purple, gold and blue, and a mesh hood and cape containing the repellant. The outfit is one of six in Ceesay’s collection, which she said “explores and modernizes traditional African silhouettes and textiles by embracing the strength and sexuality of the modern woman.”

Ceesay and Ochanda, who works with FSAD Associate Professor Juan Hinestroza, partnered with Laurie Lange, graduate student in Professor Kay Obendorf’s lab, to refine the process for capturing insecticides on the MOF-coated cloth. Hinestroza called the resulting garment “fashionable and functional, with the potential to create a new generation of durable and effective insecticide mosquito protection nets.”

The researchers are not pinning all of their hopes on the body suit (from Boscia’s April 30, 2012 article),

Ultimately, Ceesay and Ochanda hope the outfit they developed will serve as a prototype to drive new technologies for fighting the spread of malaria. On the horizon, Ochanda said, is an MOF fabric that releases repellant in response to changes in temperature or light — offering wearers more protection at night when mosquitoes are on the hunt. At minimum, they hope the technology can be applied to create longer lasting insecticide-laden bed nets.

Despite the use of mosquito nets, “people are still getting sick and dying,” Ceesay said. “We can’t get complacent. I hope my design can show what is possible when you bring together fashion and science and will inspire others to keep improving the technology. If a student at Cornell can do this, imagine how far it could go.”

Both the designer and scientist have a very personal stake in creating textiles that will repel malaria-borne mosquitoes (from Boscia’s article),

Ochanda and Ceesay, from opposite sides of the continent, both have seen family members suffer from the disease. Its prevalence in Africa — the source of 90 percent of the world’s malaria infections annually — can also lead to harmful misdiagnoses. Ceesay recalls a family member who died after doctors treated her for malaria when she had a different sickness. “It’s so common back home; you can’t escape it,” Ceesay said.

“Seeing malaria’s effect on people in Kenya, it’s very important for me to apply fiber science to help this problem,” Ochanda added. “A long-term goal of science is to be able to come up with solutions to help protect human health and life, so this project is very fulfilling for me.”

There’s no mention of how close this textile is to becoming a product and being offered in the marketplace. So, for anyone who’s generally interested in nanotechnology-enable textiles and possible economic impacts and business outlooks, Cientifica released its report, Nanotechnologies for Textile Markets in April 2012 (available for purchase). From the April 16, 2 012 news release and report description webpage,

While the traditional markets of apparel and home textiles continue to be impacted by nanotechnologies, especially in adding value through finishing and coating, the major opportunities for both textile manufacturers and nanomaterial suppliers lie elsewhere.

“Nanotechnologies for the Textile Market” takes an in depth look at the major textile markets – apparel, home, military, medical, sports, technical and smart textiles – detailing the key applications of nanotechnologies and the major players. The 255 page report contains  full market analyses and predictions for each sector to 2022, outlines the key opportunities and is illustrated with 98 figures and 30 tables.

Cientifica predicts that the highest growth over the next decade will be seen in the areas of smart and technical textiles.  In both of these areas a significant part of the added value is due to the innovative use of nanotechnologies, whether in fiber production or as a coating or additive.

With over a billion Bluetooth enabled devices on the market, ranging from smartphones to set top boxes, and new technologies such as energy scavenging or piezoelectric energy generation being made possible by the use of nanotechnologies , there are opportunities for the textile industry in new markets ranging from consumer electronics to medical diagnostics.

‘It’s a perfect storm” added Tim Harper [Cientifica's Chief Executive Office], “the availability of new materials such as graphene, the huge leaps being made in organic electronics, and the move towards the Internet of Things is blurring the divide between textiles and electronic devices. When two trillion dollar markets collide there will be lots of disruption and plenty of opportunities.”

Cientifica does offer a free download of the report’s Table of Contents (ToC). Here’s a sample from the ToC which gives you a preview  of the report’s contents,

EXECUTIVE SUMMARY  11
INTRODUCTION  21
Objectives of the Report  21
World Textiles and Clothing  22
Overview of Nanotechnology Applications in the EU Textile Industry  24
Overview of Nanotechnology Applications in the US Textile Industry 25
Overview of Nanotechnology Applications in the Chinese Textile Industry  26
Overview of Nanotechnology Applications in the Indian Textile Industry  27
Overview of Nanotechnology Applications in the Japanese Textile Industry  27
Overview of Nanotechnology Applications in the Korean Textile Industry  29
Textiles in the Rest of the World 31
Macro and Micro Value Chain of Textiles Industry  32
Common Textiles Industry Classification  32
End Markets and Value Chain Actors 32
Why Textiles Go Nano 34
Nanotechnology in Textiles 34
Nanotechnology in Some Textile-related Categories 37
Technical & Smart Textiles 37
Multifunctional Textiles 39
High Performance Textiles 39
Smart/Intelligent Textiles 39
Nanotechnology Hype 41
CURRENT APPLICATIONS OF NANOTECHNOLOGY IN TEXTILE PRODUCTION  43
Nanotechnology in Fibers and Yarns 43
Nanotechnology in Fabrics 47
Nanotechnology in Textile Finishing, Dyeing and Coating 55
Nanotechnology In Textile Printing 66
Green Technology — Nanotechnology In Textile Production Energy Saving 67
Electronic Textiles 67
Concept  67
Markets and Impacts 68
Current E-Textile Solutions and Problems 69
Nanotechnology in Electronic Textiles 78
Future and Challenges of Electronic Textiles  87
NANOTECHNOLOGY APPLICATIONS IN CLOTHING/APPAREL TEXTILES 89
Summary of Nanotechnology Applications in Clothing/Apparel Textiles 90
Current Applications of Nanotechnology in Clothing/Apparel Textiles 91
Hassle-free Clothing: Stain/Oil/Water Repellence, Anti-Static, Anti-Wrinkle 91

The Guardian newspaper in an October 4,  2011 article by Colin Stuart offers a brief , comprehensive but cautionary overview of nanotechnology-enabled textiles (thanks for the tip, Tim Harper),

The manipulation of textiles is an age-old practice, starting with the furs of the animals we hunted. As agriculture and farming grew, we began to weave natural fibres, providing us with fabrics such as cotton and wool – sartorial staples we’ve relied on for centuries.

…

Unsurprisingly, the most mainstream use of nanotextiles is in clothing. The chances are you have some nanotextiles hanging in your wardrobe; wrinkle-free or non-iron garments have been engineered against creasing by coating the fibres with nanoparticles. Nanotechnology is also responsible for the stain-resistant fabrics found in both clothing and carpets. Tiny, nano-sized hairs are added to the surface of the material which stop liquids from being absorbed. …

The nano clothing of the future, however, could add even more functionality to the latest fashions. Tomorrow’s must-wear materials could hide piezoelectrics – nanotechnology that harvests the energy created as you rub against the fabric. Imagine walking along as your every move helps charge an iPod strapped to your belt.

But nanotextiles are not just confined to clothing; they are also being used in Asia in the battle against malaria. In 2010 a group of Thai researchers announced they had created mosquito nets laced with nanoparticles of pyrethroid, an insecticide. Pyrethroid had been combined with nets before, but doing so on the nanoscale means the particles are small enough to cling to the fibres even when washed. These nano-nets can last up to five years – a five-fold improvement on conventional netting.

The article goes on to establish concerns over environmental, health, and safety regulations but I thought it best to end with the mosquito nets and malaria, which is where this posting started, more or less.

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Posted in clothing, electronics, energy, medicine, nanotechnology | 3 Comments »

Could nanoparticles in your mouthwash affect for your cells?

Monday, March 12th, 2012

The first news item I’m going to highlight was posted on Nanowerk, March 8, 2012 and is focused on the use of silver nanoparticles in mouthwashes and dentures to prevent yeast infections,

Yeasts which cause hard-to-treat mouth infections are killed using silver nanoparticles in the laboratory, scientists have found. These yeast infections, caused by Candida albicans and Candida glabrata target the young, old and immuno-compromised. Professor Mariana Henriques, University of Minho [Portugal], and her colleagues hope to test silver nanoparticles in mouthwash and dentures as a potential preventative measure against these infections.

Professor Henriques and her team, who published their research in the Society for Applied Microbiology’s journal Letters in Applied Microbiology(“Silver nanoparticles: influence of stabilizing agent and diameter on antifungal activity against Candida albicans and Candida glabrata biofilms”), looked at the use of different sizes of silver nanoparticles to determine their anti-fungal properties …

The scientists used artificial biofilms in conditions which mimic those of saliva as closely as possible. They then added different sizes and concentrations of silver nanoparticles and found that different sizes of nanoparticles were equally effective at killing the yeasts. Due to the diversity of the sizes of nanoparticles demonstrating anti-fungal properties the researchers hope this will enable the nanoparticles to be used in many different applications.

Some researchers have expressed concerns around the safety of nanoparticle use but the authors stress this research is at an early stage and extensive safety trials will be carried out before any product reaches the market. [emphasis mine]

Following on the notion of safety and gargling silver nanoparticles, coincidentally, there was another news item also dated March 8, 2012 on Nanowerk, this one about the impact that nanoparticles may have on nutrient uptake,

Nanoparticles are everywhere. From cosmetics and clothes, to soda and snacks. But as versatile as they are, nanoparticles also have a downside, say researchers at Binghamton University and Cornell University in a recent paper published in the journal Nature Nanotechnology (“Oral exposure to polystyrene nanoparticles affects iron absorption”). These tiny particles, even in low doses, could have a big impact on our long-term health.

According to lead author of the article, Gretchen Mahler, assistant professor of bioengineering at Binghamton University, much of the existing research on the safety of nanoparticles has been on the direct health effects. But what Mahler, Michael L. Shuler of Cornell University and a team of researchers really wanted to know was what happens when someone gets constant exposure in small doses – the kind you’d get if you were taken a drug or supplement that included nanoparticles in some form. [e.g. silver nanoparticles in your mouthwash or on your dentures]

“We thought that the best way to measure the more subtle effects of this kind of intake was to monitor the reaction of intestinal cells,” said Mahler. “And we did this in two ways: in vitro, through human intestinal-lining cells that we had cultured in the lab; and in vivo, through the intestinal linings of live chickens. Both sets of results pointed to the same thing – that exposure to nanoparticles influences the absorption of nutrients into the bloodstream.”

As for why the researchers focused on iron and tested polystyrene nanoparticles (from the news item),

The uptake of iron, an essential nutrient, was of particular interest due to the way it is absorbed and processed through the intestines. The way Mahler and the team tested this was to use polystyrene nanoparticles because of its easily traceable fluorescent properties.

“What we found was that for brief exposures, iron absorption dropped by about 50 percent,” said Mahler. “But when we extended that period of time, absorption actually increased by about 200 percent. It was very clear – nanoparticles definitely affects iron uptake and transport.”

While acute oral exposure caused disruptions to intestinal iron transport, chronic exposure caused a remodeling of the intestinal villi – the tiny, finger-like projections that are vital to the intestine’s ability to absorb nutrients – making them larger and broader, thus allowing iron to enter the bloodstream much faster.

As to whether these changes are good or bad the researchers don’t speculate. They do have plans for more testing,

calcium,
copper,
zinc, and
fat-soluble vitamins A, D, E and K

They don’t mention any changes in the types of nanoparticles they might be testing in future.

In any event, our bodies have changed a lot over the centuries, you just have to visit a pyramid in Egypt or a museum that holds medieval armour to observe that humans were once much shorter than we are today.

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Posted in food, health and safety, nanotechnology | 1 Comment »

Graphene: scientific rock star? Sweden, and FET

Wednesday, November 9th, 2011

Well, some think graphene is a scientific rock star according to the Nov. 9, 2011 news item on Nanowerk,

Graphene is sort of a scientific rock star, with countless groups studying its amazing electrical properties and tensile strength and dreaming up applications ranging from flat-panel screens to elevators in space.

That’s what a research group (Craighead Research Group) at Cornell University is saying about graphene in its article, “Fabrication and performance of graphene nanoelectromechanical systems” published n the Journal of Vacuum Science and Technology B, 2011, vol. 29 (5).

There’s no question that graphene is a sizzling topic these days and much money is being flung in that direction for research. The Nov. 8, 2011 news item on Nanowerk features a major chunk of funding (which may also have an impact on a huge European Union funding project next year) for a graphene research group in Sweden,

Graphene can enable the best quantum resistance standard. This is one of many advances emerging from the active research into graphene at Chalmers University of Technology. Chalmers will now receive the lion’s share of a new Swedish research grant of SEK 40 million [approximately $6M CAD] for the supermaterial graphene.

Following the new financing from the Knut and Alice Wallenberg Foundation, a group of some 30 Swedish graphene researchers will be formed, in a close collaboration between Chalmers and the universities of Uppsala and Linköping. The effort will form the Swedish spearhead in international graphene research – a hot topic ever since the Nobel Physics Prize in 2010.

…

The Chalmers researchers have already achieved several important breakthroughs with graphene, despite the fact that the material was first produced as recently as 2004. One example is a new standard for the quantum of resistance – a “tuning fork” for calibrating the correct resistance in electrical instruments and devices. State-of-the-art resistance standards are based on silicon or gallium arsenide. These are difficult to manufacture, and the method only works at extremely low temperatures and in large magnetic fields. A new generation of resistance standards based on graphene are at least as accurate as those in use today, while benefitting from being substantially easier to produce and use.

In another project, Chalmers researchers have produced a graphene transistor that operates at more than 10 gigahertz. They are now working on producing one capable of reaching into the terahertz range – in other words faster than 100 gigahertz. This may become possible thanks to a large grant that Mikael Fogelström’s research group received earlier this year from the Foundation for Strategic Research – SEK 28.5 million over a five-year period.

The Future and Emerging Technologies in information technology (Fet 11) is the name for the European Union’s 2011 Pathfinder programme, which will be awarding $1B Euros in mid-2012, and which was mentioned in my June 13, 2011 posting about graphene. Here’s an excerpt from that posting,

Bringing together multiple disciplines and addressing research across a whole range of issues, from fundamental understandings of material properties to Graphene production, the Flagship will provide the platform for establishing European scientific and technological leadership in the application of Graphene to Information and Communication Technologies. The proposed research includes coverage of electronics, spintronics, photonics, plasmonics and mechanics, all based on Graphene.

[Project Team:]

Andrea Ferrari, Cambridge University, UK
Jari Kinaret, Chalmers University, Sweden
Vladimir Falko, Lancaster University, UK
Jani Kivioja, NOKIA, Finland [emphasis mine]

2011 has been quite the year for these researchers at Chalmers since they were one of six research groups getting funds to produce more work in preparation for a final round of considerations before deciding which two groups would be receiving $1B Euro each in 2012.

I gather from the news item on Nanowerk, this latest funding will aid in next year’s big decision,

Chalmers has previously gathered together European graphene researchers for a major research initiative competing for what is known as “Future Emerging Technology Flagship” funds, providing finance of up to SEK 10 billion over 10 years. Next year, the EU will decide whether to convert the pilot project into a flagship. The new research grant from the Knut and Alice Wallenberg Foundation is believed to increase the chances of that happening.

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Posted in electronics, nanotechnology | 1 Comment »

Princeton goes Open Access; arXiv is 10 years old

Friday, September 30th, 2011

Open access to science research papers seems only right given that most Canadian research is publicly funded. (As I understand it most research worldwide is publicly funded.)

This week, Princeton University declared that their researchers’ work would be mostly open access (from the Sept. 28, 2011 news item on physrog.com),

Prestigious US academic institution Princeton University has banned researchers from giving the copyright of scholarly articles to journal publishers, except in certain cases where a waiver may be granted.

Here’s a little more from Sunanda Creagh’s (based in Australia) Sept.28, 2011 posting on The Conversation blog,

The new rule is part of an Open Access policy aimed at broadening the reach of their scholarly work and encouraging publishers to adjust standard contracts that commonly require exclusive copyright as a condition of publication.

Universities pay millions of dollars a year for academic journal subscriptions. People without subscriptions, which can cost up to $25,000 a year for some journals or hundreds of dollars for a single issue, are often prevented from reading taxpayer funded research. Individual articles are also commonly locked behind pay walls.

Researchers and peer reviewers are not paid for their work but academic publishers have said such a business model is required to maintain quality.

This Sept. 29, 2011 article by James Chang for the Princetonian adds a few more details,

“In the interest of better disseminating the fruits of our scholarship to the world, we did not want to put it artificially behind a pay wall where much of the world won’t have access to it,” committee chair and computer science professor Andrew Appel ’81 said.

The policy passed the Faculty Advisory Committee on Policy with a unanimous vote, and the proposal was approved on Sept. 19 by the general faculty without any changes.

A major challenge for the committee, which included faculty members in both the sciences and humanities, was designing a policy that could comprehensively address the different cultures of publication found across different disciplines.

While science journals have generally adopted open-access into their business models, humanities publishers have not. In the committee, there was an initial worry that bypassing the scholarly peer-review process that journals facilitate, particularly in the humanities, could hurt the scholarly industry.

At the end, however, the committee said they felt that granting the University non-exclusive rights would not harm the publishing system and would, in fact, give the University leverage in contract negotiations.

That last comment about contract negotiations is quite interesting as it brings to mind the California boycott of the Nature journals last year when Nature made a bold attempt to raise subscription fees substantively (400%) after having given the University of California special deals for years (my June 15, 2010 posting).

Creagh’s posting features some responses from Australian academics such as Simon Marginson,

Having prestigious universities such as Princeton and Harvard fly the open access flag represented a step forward, said open access advocate Professor Simon Marginson from the University of Melbourne’s Centre for the Study of Higher Education.

“The achievement of free knowledge flows, and installation of open access publishing on the web as the primary form of publishing rather than oligopolistic journal publishing subject to price barriers, now depends on whether this movement spreads further among the peak research and scholarly institutions,” he said.

“Essentially, this approach – if it becomes general – normalises an open access regime and offers authors the option of opting out of that regime. This is a large improvement on the present position whereby copyright restrictions and price barriers are normal and authors have to attempt to opt in to open access publishing, or risk prosecution by posting their work in breach of copyright.”

“The only interests that lose out under the Princeton proposal are the big journal publishers. Everyone else gains.”

Whether you view Princeton’s action as a negotiating ploy and/or a high minded attempt to give freer access to publicly funded research,  this certainly puts pressure on the business models that scholarly publishers follow.

arXiv, celebrating its 10th anniversary this year, is another open access initiative although it didn’t start that way. From the Sept. 28, 2011 news item on physorg.com,

“I’ve heard a lot about how democratic the arXiv is,” Ginsparg [Paul Ginsparg, professor of physics and information science] said Sept. 23 in a talk commemorating the anniversary. People have, for example, praised the fact that the arXiv makes scientific papers easily available to scientists in developing countries where subscriptions to journals are not always affordable. “But what I was trying to do was set up a system that eliminated the hierarchy in my field,” he said. As a physicist at Los Alamos National Laboratory, “I was receiving preprints long before graduate students further down the food chain,” Ginsparg said. “When we have success we like to think it was because we worked harder, not just because we happened to have access.”

Bill Steele’s Sept. 27, 2011 article for Cornell Univesity’s ChronicleOnline notes,

One of the surprises, Ginsparg said, is that electronic publishing has not transformed the seemingly irrational scholarly publishing system in which researchers give their work to publishing houses from which their academic institutions buy it back by subscribing to journals. Scholarly publishing is still in transition, Ginsparg said, due to questions about how to fund electronic publication and how to maintain quality control. The arXiv has no peer-review process, although it does restrict submissions to those with scientific credentials.

But the lines of communication are definitely blurring. Ginsparg reported that a recent paper posted on the arXiv by Alexander Gaeta, Cornell professor of applied and engineering physics, was picked up by bloggers and spread out from there. The paper is to be published in the journal Nature and is still under a press embargo, but an article about it has appeared in the journal Science.

Interesting, eh? It seems that scholarly publishing need not disappear but there’s no question its business models are changing.

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Posted in writing | 4 Comments »

Rejecting creativity?

Monday, September 5th, 2011

Most people know this from experience. We laud creativity in theory while attempting to crush it in practice. If you doubt this, try launching a new idea at a meeting. In fact, trying to launch a new idea anywhere at any time is difficult as anyone who’s tried will tell you. Frustratingly, people don’t necessarily believe you when you point it out. They’re more likely to announce that the idea couldn’t have been much good in the first place or perhaps laugh at you because the idea seems so crazy or there’s dead silence because they can’t understand what you’re talking about. (Yes, I’ve had a few bad experiences.) So I was thrilled to see a study that confirms my experience. From the Sept. 3, 2011 news item on Science Daily, Why We Crave Creativity but Reject Creative Ideas,

The next time your great idea at work elicits silence or eye rolls, you might just pity those co-workers. Fresh research indicates they don’t even know what a creative idea looks like and that creativity, hailed as a positive change agent, actually makes people squirm.

“How is it that people say they want creativity but in reality often reject it?” said Jack Goncalo, ILR [Industrial and Labor Relations] School [at Cornell University] assistant professor of organizational behavior and co-author of research to be published in an upcoming issue of the journal Psychological Science. The paper reports on two 2010 experiments at the University of Pennsylvania involving more than 200 people.

The studies’ findings include:

  • Creative ideas are by definition novel, and novelty can trigger feelings of uncertainty that make most people uncomfortable.
  • People dismiss creative ideas in favor of ideas that are purely practical — tried and true.
  • Objective evidence shoring up the validity of a creative proposal does not motivate people to accept it.
  • Anti-creativity bias is so subtle that people are unaware of it, which can interfere with their ability to recognize a creative idea.

For example, subjects had a negative reaction to a running shoe equipped with nanotechnology that adjusted fabric thickness to cool the foot and reduce blisters. [emphasis mine]

While I don’t always require a connection to nanotechnology in postings like this this, it’s nice to find one. And, I’m quite, quite surprised that people would not leap for joy at the thought of a shoe that would cool your foot and reduce the incidence of blisters. Who’d reject that? Apparently, more than one of us. Here’s more from the researchers,

“Our findings imply a deep irony,” wrote the authors, who also include Jennifer Mueller of the University of Pennsylvania and Shimul Melwani of the University of North Carolina, Chapel Hill. “Revealing the existence and nature of a bias against creativity can help explain why people might reject creative ideas and stifle scientific advancements, even in the face of strong intentions to the contrary.”

I hope I’ll have a chance to read the studies once they’re published and I hope the researchers will have the opportunity to tackle some other related questions such as why do we accept new ideas? If we rejected everything, we wouldn’t have agriculture, the wheel, money, etc. Plus, I also know that while I’m open to new ideas and have generated a few of my own, I have missed the boat on occasion. If I’d been in charge, there never would have been a camera included in a phone. By what means am I (or is anyone) more open to a new idea since the nanotechnology in the footwear wouldn’t be a problem for me but the phone camera was?

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Posted in clothing, nanotechnology, science, Uncategorized | No Comments »

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