Posts Tagged ‘Dexter Johnson’

Memristors have always been with us

Friday, June 14th, 2013

Sprightly, a word not often used in conjunction with technology of any kind,  is the best of way describing the approach that researchers Varun Aggarwal and Gaurav Gandhi, along with Dr. Leon Chua, have taken towards their discovery that memristors are all around us. ( For anyone not familiar with the concept, I suggest reading the Wikipedia essay on memristors as it includes information about the various critiques of the memristor definition, as well as, the definition.)

It was Dexter Johnson in his June 6, 2013 post on the IEEE (Institute of Electrical and Electronics Engineers) Nanoclast blog who alerted me to this latest memristor work (Note: Links have been removed),

Two researchers from mLabs in India, along with Prof. Leon Chua at the University of California Berkeley, who first postulated the memristor in a paper back in 1971, have discovered the simplest physical implementation for the memristor, which can be built by anyone and everyone.

In two separate papers, one published in arXiv (“Bipolar electrical switching in metal-metal contacts”) and the other in the IEEE’s own Circuits and Systems Magazine (“The First Radios Were Made Using Memristors!”), Chua and the researchers, Varun Aggarwal and Gaurav Gandhi, discovered that simple imperfect point contacts all around us act as memristors.

“Our arXiv paper talks about the coherer, which comprises an imperfect metal-metal contact in embodiments such as a point contact between two metallic balls, granular media or a metal-mercury interface,” Gandhi explained to me via e-email. “On the other hand, the CAS paper comprises an imperfect metal-semiconductor contact (Cat’s Whisker) which was also the first solid-state diode. Both the systems have as their signature an imperfect point contact between two conducting/partially-conducting elements. Both act like memristor.”

I’ll get to the articles in a minutes, first let’s look at the researchers’ website, Mlabs home page (splash page). BTW, I have a soft spot for websites that are easy to navigate and don’t irritate me with movement or pop-ups (thank you mLabs). I think this description of the researchers (Aggarwal and Gandhi) and how they came to develop mLabs (excerpted from the About us page) explains why I described their approach as sprightly,

As they say, anything can happen over a cup of coffee and this story is no different! Gaurav and Varun were friends for over a decade, and one fine day they were sitting at a coffee house discussing Gaurav’s trip to the Second Memristor and Memristive Symposium at Berkeley. Gaurav shared the exciting work around memristor that he witnessed at Berkeley. Varun, who has been an evangelist of Jagadish Chandra Bose’s work thought there was some correlation between the research work of Bose and memristor. He convinced Gaurav to look deeper into these aspects. Soon, a plan was put forth, they wore their engineering gloves and mLabs was born. Gaurav quit his job for full time involvement at mLabs, while Varun assisted and advised throughout.

Three years of curiosity, experimentation, discussions and support from various researchers and professors from different parts of the world, led us to where we are today.

We are also sincerely grateful to Prof. Leon Chua for his continuous support, mentorship and indispensable contribution to our work.

As Dexter notes, Aggarwal and Gandhi have written papers about two different ways to create memristors, the arXiv paper, Bipolar electrical switching in metal-metal contacts, describes how corherers could be used to create simple memristors for research purposes. This paper also makes the argument that the memristor is a fundamental circuit (a claim which is a matter of considerable debate as the Wikipedia Memristor essay notes briefly),

Our new results show that bipolar switching can be observed in a large class of metals by a simple construction in form of a point-contact or granular media. It does not require complex construction, particular materials or small geometries. The signature of all our devices is an imperfect metal-metal contact and the physical mechanism for the observed behavior needs to be further studied. That the electrical behavior of these simple, naturally-occurring physical constructs can be modeled by a memristor, but not the other three passive elements, is an indication of its fundamental nature. By providing the canonic physical implementation for memristor, the present work not only lls an important gap in the study of switching devices, but also brings them into the realm of immediate practical use and implementation.

Due to the fact that the second article, the one in the IEEE published Circuits and Systems magazine, is behind a paywall, I can’t do much more than offer the title and the first paragraph,

The First Radios Were Made Using Memristors!

In 2008, Williams et al. reported the discovery of the fourth fundamental passive circuit element, memristor, which exhibits electrically controllable state-dependent resistance [1]. We show that one of the first wireless radio detector, called cat?s whisker, also the world?s first solid-state diode, had memristive properties. We have identified the state variable governing the resistance state of the device and can program it to switch between multiple stable resistance states. Our observations and results are valid for a larger class of devices called coherers, which include the cat?s whisker. These devices constitute the missing canonical physical implementations for a memristor (ref. Fig. 1).

It’s fascinating when you consider that up until now researching memristors meant having high tech equipment. I wonder how many backyard memristor labs are going to spring up?

On a somewhat related note, Dexter mentions that HP Labs ‘memristor’ products will be available in 2014. This latest date represents two postponements. Originally meant to be on the market in the summer of 2013, the new products were then supposed to brought to market in late 2013 as per my Feb. 7, 2013 posting; scroll down about 75% of the way).

No more carbon nanotubes from Bayer MaterialScience

Thursday, May 9th, 2013

A May 8, 2013 news item on Nanowerk proclaims,

Bayer MaterialScience intends to focus its development activities more intently on topics that are closely linked to its core business. For that reason the company will bring its work on carbon nanotubes (CNTs) to a close. Precisely how the research results and know-how for the production and application CNT will be used further will be determined shortly.

Researchers from Bayer MaterialScience had collaborated with external partners in recent years to resolve complex issues related to the safe production of specific carbon nanotubes. [emphasis mine] Methods for scaling up the production processes were developed, as were new generations of catalysts and new types of products.

The timing for this announcement from Bayer MateriaScience is interesting given that the US National Institute of Occupational Health and Safety (NIOSH) just announced some stringent recommendations (almost zero) for occupational exposure to carbon nanofibers and carbon nanotubes (my Apr. 28, 2013 posting).

The May 8, 2013 Bayer MaterialScience news release, which originated the news item, provides more detail about the business decision,

Much of the knowledge gleaned over recent years was made available to other companies and research institutions within the Innovation Alliance Carbon Nanotubes (Inno.CNT), which counts Bayer MaterialScience among its roughly 90 members.

“We remain convinced that carbon nanotubes have huge potential,” says Patrick Thomas, Chief Executive Officer of Bayer MaterialScience. It has been found, however, that the potential areas of application that once seemed promising from a technical standpoint are currently either very fragmented or have few overlaps with the company’s core products and their application spectrum.

“For Bayer MaterialScience, groundbreaking applications for the mass market relating to our own portfolio and therefore comprehensive commercialization are not likely in the foreseeable future,” says Thomas. Nonetheless, this know-how provides an important basis for a possible later use of CNT, for example in the optimization of lithium ion batteries, Thomas says. “We are currently in contact with potential interested parties regarding the specific application of the know-how generated,” Thomas adds.

The conclusion of the nano projects has no impact on the headcount. All 30 people employed in this sector will be transferred to other suitable positions within the Group.

I”m glad to hear no one will lose their job.

Finally, I recall reading somewhere that there was a glut of carbon nanotube production and taking that with the recent NIOSH recommendation and Bayer’s claim of poor prospects for commercialization, it seems like one of those decisions that made itself.

ETA May 20, 2013: Dexter Johnson provides some insight into carbon nanotube production and the glut in his May 18, 2013 posting on Nanoclast (on the IEEE [Institute of Electrical and Electronics Engineers] website),

This [Bayer MaterialScience decision] is no surprise since there was a huge glut of product resulting in industry utilization rates that must have been in the single digits. This oversupplied market was the result of a MWNT [multi-walled nanotube] capacity arms race that started in the mid-2000s.

I recommend reading the rest of the posting where Dexter goes on to describe how pricing dropped precipitously from 2006 to 2009  and the resultant efforts to develop markets for the product.

Mop up the oil spills with nanosheets from Deakin University and The Conversation

Thursday, May 2nd, 2013

Researchers from Deakin University (Australia) have developed a new material, boron-based nanosheets, which can mop up oil spills more efficiently than current methods and are recyclable. From the May 1, 2013 news item on Nanowerk, (Note: A link has been removed)

In Nature Communications today (“Porous boron nitride nanosheets for effective water cleaning”), we showed how we produced, probably for the first time, nanosheets that could revolutionise oil spill clean ups and water purification.

Not only do our nanosheets absorb 33 times their weight in oil, they’re also recyclable.

Ordinarily there’d be a news release from Deakin University but these researchers appear to have taken a different approach posting on a website called The Conversation. This is a very interesting science communicaton initiative from Australia and I will be digressing for a moment. Here’s a description of the initiative from their Who We Are page,

The Conversation is an independent source of news and views, sourced from the academic and research community and delivered direct to the public.

Our team of professional editors work with university, CSIRO and research institute experts to unlock their knowledge for use by the wider public.

Access to independent, high-quality, authenticated, explanatory journalism underpins a functioning democracy. Our aim is to allow for better understanding of current affairs and complex issues. And hopefully allow for a better quality of public discourse and conversations.

We have introduced new protocols and controls to help rebuild trust in journalism. All authors and editors sign up to our Editorial Charter and Code of Ethics. And all contributors must abide by our Community Standards policy. We only allow authors to write on a subject on which they have proven expertise, which they must disclose alongside their article. Authors’ funding and potential conflicts of interest must be disclosed. Failure to do so carries a risk of being banned from contributing to the site.

Since our launch in March 2011, we’ve grown to become one of Australia’s largest independent news and commentary sites. Around 35% of our readers are from outside Australia.

We believe in open access and the free-flow of information. The Conversation is a free resource: free to read (we’ll never go behind a paywall), and free to share or republish under Creative Commons. All you need to do is follow our simple guidelines. We have also become an indispensable media resource: providing free content, ideas and talent to follow up for press, web, radio or TV.

They believe in open access and the free-flow of information as long as you don’t edit the article, etc. Here are five of the guidelines (from the Republishing guidelines page),

Republishing guidelines, for print and online

  1. Unless you have express permission from the author, you can’t edit our material, except to reflect relative changes in time, location and editorial style. (For example, “yesterday” can be changed to “last week,” and “Canberra, ACT.” to “Canberra” or “here”). If you need to materially edit our content, please contact our External Relations Manager.
  2. You have to credit our authors and partner institutions — ideally in the byline. We prefer “Author Name, Institution” (for example, Qing Wang, Warwick Business School).
  3. You have to credit The Conversation — ideally at the top of the article and include our logo — with a link back to either our home page, The Conversation, or (preferably) the specific article URL on The Conversation website.
  4. If space is tight, you can run the first few lines of the article and then say: “Read the full article at The Conversation” with a link back to the article page on our site.
  5. If you’re republishing online, you must use our page view counter, link to us, and include links from our story. Our page view counter is a small pixel-ping image (invisible to the eye) that allows us to know when our content is republished, and gives our authors sense of the size of audience and which publications they’re reaching. It is a condition of our guidelines that you include our counter. If you use the “republish” button that accompanies each article then you’ll capture our page counter.
  6. ….

Since I usually cut and paste parts of articles and news releases and often intersperse with my own comments and I don’t have the technical skills to use their page view counter, I won’t be using anything directly from The Conversation. I view my role as a curator (bringing together pieces of information from disparate sources) and a ‘connector’. To encourage connections, I don’t usually include a full news release or article as I suggest my readers look at the original or seek out the other sources I’ve included if they want more information.

Back to the boron nitride nanosheets and the news item on Nanowerk,

We found that porous boron nitride nanosheets have a couple of properties that make them particularly suitable for absorbing organic (carbon-based) contaminants, such as oil or dyes.

The nanosheets are made of a few layers of boron nitride atomic planes, and these sheets have a large number of holes.

It’s these holes that increase the surface area of the nanosheets to a huge 1,425m2 a gram.
This means one gram of porous boron nitride nanosheets has the same surface area as nearly 5.5 tennis courts – so plenty of surface for absorption.

Another advantage is that the saturated boron nitride nanosheets can be cleaned for reuse by simply heating in air for two hours.

The absorbed oil is burned off, leaving the nanosheets clean and free to absorb again.

To make our porous nanosheets, boron oxide powder and guanidine hydrochloride are mixed in methane and heated at 1,100C for several hours in nitrogen gas.

The news item on Nanowerk is illustrated with images and provides more detail as does the May 1, 2013 article (Don’t cry over spilled oil – use nanosheets) on The Conversation.

For those who’d like to read the published research, here’s a link to and a citation for it,

Porous boron nitride nanosheets for effective water cleaning by Weiwei Lei, David Portehault, Dan Liu, Si Qin, & Ying Chen. Nature Communications 4, Article number: 1777 doi:10.1038/ncomms2818 Published 30 April 2013

The article is behind a paywall.

Interestingly scientists in China have developed an entirely different material with similar properties for mopping up oil spills as per my Feb. 27, 2013 posting titled, Bacterial cellulose could suck up pollutants from oil spills.

ETA May 6, 2013: Dexter Johnson has commented on an outstanding issue with the Deakin University research and other such initiatives: a lack of commercialization efforts. From his May 4, 2013 posting on his Nanoclast blog (found on the IEEE [Institute of Electrical and Electronics Engineers] website), Note: A link has been removed,

In fact, there are a variety of nanomaterials for these applications [oil spill remediation and water purification]—so many of them that there are catalogues to guide you through them.  But not so fast. As yet, no one is bothering to commercialize them so that they are available for the next oil spill.

Dexter provides worthwhile context and some provocative comments on how to ‘encourage’ commercialization of nanotechnology-enabled oil spill remediation/water purification  products.

Bee venom, HIV (human immunodeficiency virus), and targeted nanoparticles

Monday, March 11th, 2013

Researchers at Washington University School of Medicine in St Louis (Missouri, US) have found a way to use nanoparticles impregnated with bee venom to hopelessly damage HIV (human immunodeficiency virus) in laboratory tests, according to a Mar. 7, 2013 news release on EurekAlert,

Nanoparticles carrying a toxin found in bee venom can destroy human immunodeficiency virus (HIV) while leaving surrounding cells unharmed, researchers at Washington University School of Medicine in St. Louis have shown. The finding is an important step toward developing a vaginal gel that may prevent the spread of HIV, the virus that causes AIDS.

“Our hope is that in places where HIV is running rampant, people could use this gel as a preventive measure to stop the initial infection,” says Joshua L. Hood, MD, PhD, a research instructor in medicine.

 Nanoparticles (purple) carrying melittin (green) fuse with HIV (small circles with spiked outer ring), destroying the virus’s protective envelope. Molecular bumpers (small red ovals) prevent the nanoparticles from harming the body’s normal cells, which are much larger in size.  Credit: Joshua L. Hood, MD, PhD (downloaded from: http://news.wustl.edu/news/Pages/25061.aspx

Nanoparticles (purple) carrying melittin (green) fuse with HIV (small circles with spiked outer ring), destroying the virus’s protective envelope. Molecular bumpers (small red ovals) prevent the nanoparticles from harming the body’s normal cells, which are much larger in size. Credit: Joshua L. Hood, MD, PhD (downloaded from: http://news.wustl.edu/news/Pages/25061.aspx

Dexter Johnson in his Mar. 8, 2013 posting on Nanoclast (IEEE [Institute of Electrical and Electronics Engineers] blog) contextualizes this research with links to other related research along with his comments about this latest work (Note: A link has been removed),

The research, which was published in the journal Antiviral Therapy (“Cytolytic nanoparticles attenuate HIV-1 infectivity”), employed a nanoparticle that had previously been abandoned when it proved ineffective for delivering oxygen to blood cells. But in its new role, carrying the toxin melittin, a poison found in bee venom, it is extremely effective at breaking down the essential structure of HIV.

The Washington University in Saint Louis Mar. 7, 2013 news release (and origin for EurekAlert news release) written by Julia Evangelou Strait provides details about the research,

Bee venom contains a potent toxin called melittin that can poke holes in the protective envelope that surrounds HIV, and other viruses. Large amounts of free melittin can cause a lot of damage. Indeed, in addition to anti-viral therapy, the paper’s senior author, Samuel A. Wickline, MD, the J. Russell Hornsby Professor of Biomedical Sciences, has shown melittin-loaded nanoparticles to be effective in killing tumor cells.

The new study shows that melittin loaded onto these nanoparticles does not harm normal cells. That’s because Hood added protective bumpers to the nanoparticle surface. When the nanoparticles come into contact with normal cells, which are much larger in size, the particles simply bounce off. HIV, on the other hand, is even smaller than the nanoparticle, so HIV fits between the bumpers and makes contact with the surface of the nanoparticle, where the bee toxin awaits.

“Melittin on the nanoparticles fuses with the viral envelope,” Hood says. “The melittin forms little pore-like attack complexes and ruptures the envelope, stripping it off the virus.”

According to Hood, an advantage of this approach is that the nanoparticle attacks an essential part of the virus’ structure. In contrast, most anti-HIV drugs inhibit the virus’s ability to replicate. But this anti-replication strategy does nothing to stop initial infection, and some strains of the virus have found ways around these drugs and reproduce anyway.

“We are attacking an inherent physical property of HIV,” Hood says. “Theoretically, there isn’t any way for the virus to adapt to that. The virus has to have a protective coat, a double-layered membrane that covers the virus.”

Beyond prevention in the form of a vaginal gel, Hood also sees potential for using nanoparticles with melittin as therapy for existing HIV infections, especially those that are drug-resistant. The nanoparticles could be injected intravenously and, in theory, would be able to clear HIV from the blood stream.

While this work was done in cells in a laboratory environment, Hood and his colleagues say the nanoparticles are easy to manufacture in large enough quantities to supply them for future clinical trials.

Here’s a citation and link to the paper,

Joshua L Hood, Andrew P Jallouk, Nancy Campbell, Lee Ratner, Samuel A Wickline. Cytolytic nanoparticles attenuate HIV-1 infectivity. Antiviral Therapy. Vol. 19: 95 – 103. 2013

The article is behind a paywall.

Samsung ‘GROs’ graphene-based micro-antennas and a brief bit about the business of nanotechnology

Monday, February 25th, 2013

A Feb. 22, 2013 news item on Nanowerk highlights a Samsung university grant (GRO) programme which announced funding for graphene-based micro-antennas,

The Graphene-Enabled Wireless Communication project, one of the award-winning proposals under the Samsung Global Research Outreach (GRO) programme, aims to use graphene antennas to implement wireless communication over very short distances (no more than a centimetre) with high-capacity information transmission (tens or hundreds of gigabits per second). Antennas made ??of [sic] graphene could radiate electromagnetic waves in the terahertz band and would allow for high-speed information transmission. Thanks to the unique properties of this nanomaterial, the new graphene-based antenna technology would also make it possible to manufacture antennas a thousand times smaller than those currently used.

The GRO programme—an annual call for research proposals by the Samsung Advanced Institute of Technology (Seoul, South Korea)—has provided the UPC-led project with US$120,000 in financial support.

The Graphene-Enabled Wireless Communication project is a joint project (from the news item; Note: A link has been removed),

“Graphene-Enabled Wireless Communications” – a proposal submitted by an interdepartmental team based at the Universitat Politècnica de Catalunya, BarcelonaTech (UPC) and the Georgia Institute of Technology (Georgia Tech)—will receive US$120,000 to develop micrometre-scale graphene antennas capable of transmitting information at a high speed over very short distances. The project will be carried out in the coming months.

The Graphene-Enabled Wireless Communication project, one of the award-winning proposals under the Samsung Global Research Outreach (GRO) programme, aims to use graphene antennas to implement wireless communication over very short distances (no more than a centimetre) with high-capacity information transmission (tens or hundreds of gigabits per second). Antennas made ??of graphene could radiate electromagnetic waves in the terahertz band and would allow for high-speed information transmission. Thanks to the unique properties of this nanomaterial, the new graphene-based antenna technology would also make it possible to manufacture antennas a thousand times smaller than those currently used.

There’s more about the Graphene-Enabled Wireless Communication project here,

 A remarkably promising application of graphene is that of Graphene-enabled Wireless Communications (GWC). GWC advocate for the use of graphene-based plasmonic antennas -graphennas, see Fig. 1- whose plasmonic effects allow them to radiate EM waves in the terahertz band (0.1 – 10 THz). Moreover, preliminary results sustain that this frequency band is up to two orders of magnitude below the optical frequencies at which metallic antennas of the same size resonate, thereby enhancing the transmission range of graphene-based antennas and lowering the requirements on the corresponding transceivers. In short, graphene enables the implementation of nano-antennas just a few micrometers in size that are not doable with traditional metallic materials.

Thanks to both the reduced size and unique radiation capabilities of ZZ, GWC may represent a breakthrough in the ultra-short range communications research area. In this project we will study the application of GWC within the scenario of off-chip communication, which includes communication between different chips of a given device, e.g. a cell phone.

A new term, graphenna, appears to be have been coined. The news item goes on to offer more detail about the project and about the number of collaborating institutions,

The first stage of the project, launched in October 2012, focuses on the theoretical foundations of wireless communications over short distances using graphene antennas. In particular, the group is analysing the behaviour of electromagnetic waves in the terahertz band for very short distances, and investigating how coding and modulation schemes can be adapted to achieve high transmission rates while maintaining low power consumption.

The group believes the main benefits of the project in the medium term will derive from its application for internal communication in multicore processors. Processors of this type have a number of sub-processors that share and execute tasks in parallel. The application of wireless communication in this area will make it possible to integrate thousands of sub-processors within a single processor, which is not feasible with current communication systems.

The results of the project will lead to an increase in the computational performance of these devices. This improvement would allow large amounts of data to be processed at very high speed, which would be very useful for streamlining data management at processing centres (“big data”) used, for example, in systems like Facebook and Google. The project, which builds on previous results obtained with the collaboration of the University of Wuppertal in Germany, the Royal Institute of Technology (KTH) in Sweden, and Georgia Tech in the United States, is expected to yield its first results in April 2013.

The project is being carried out by the NaNoNetworking Centre in Catalonia (N3Cat), a network formed at the initiative of researchers with the UPC’s departments of Electronic Engineering and Computer Architecture, together with colleagues at Georgia Tech.

Anyone interested in  Samsung’s GRO programme can find more here,

The SAMSUNG Global Research Outreach (GRO) program, open to leading universities around the world, is Samsung Electronics, Co., Ltd. & related Samsung companies (SAMSUNG)’s annual call for research proposals.

As this Samsung-funded research project is being announced, Dexter Johnson details the business failure of NanoInk in a Feb. 22, 2013 posting on his Nanoclast blog (on the IEEE [International Institute of Electrical and Electronics Engineers] website), Note: Links have been removed,

One of the United State’s first nanotechnology companies, NanoInk, has gone belly up, joining a host of high-profile nanotechnology-based companies that have shuttered their doors in the last 12 months: Konarka, A123 Systems and Ener1.

These other three companies were all tied to the energy markets (solar in the case of Konarka and batteries for both A123 and Ener1), which are typically volatile, with a fair number of shuttered businesses dotting their landscapes. But NanoInk is a venerable old company in comparison to these other three and is more in what could be characterized as the “picks-and-shovels” side of the nanotechnology business, microscopy tools.

Dexter goes on to provide an  analysis of the NanoInk situation which makes for some very interesting reading along with the comments—some feisty, some not—his posting has provoked.

I am juxtaposing the Samsung funding announcement with this mention of Dexter’s piece regarding a  ‘nanotechnology’ business failure in an effort to provide some balance between enthusiasm for the research and the realities of developing businesses and products based on that research.

The yin and the yang of carbon nanotubes and toxicity

Wednesday, January 16th, 2013

 

Illustration courtesy of the University College of London (UCL). Downloaded from http://www.ucl.ac.uk/news/news-articles/0113/130115-chemistry-resolves-toxic-concerns-about-carbon-nanotubes

Illustration courtesy of the University College of London (UCL). Downloaded from http://www.ucl.ac.uk/news/news-articles/0113/130115-chemistry-resolves-toxic-concerns-about-carbon-nanotubes

Researchers at the University College of London (UCL), France’s Centre national de la recherche scientifique (CNRS), and Italy’s University of Trieste have determined that carbon nanotube toxicity issues can be addressed be reducing their length and treating them chemically. From the Jan. 15,2013 news item on ScienceDaily,

In a new study, published January 15 [2013] in the journal Angewandte Chemie, evidence is provided that the asbestos-like reactivity and pathogenicity reported for long, pristine nanotubes can be completely alleviated if their surface is modified and their effective length is reduced as a result of chemical treatment.

First atomically described in the 1990s, carbon nanotubes are sheets of carbon atoms rolled up into hollow tubes just a few nanometres in diameter. Engineered carbon nanotubes can be chemically modified, with the addition of chemotherapeutic drugs, fluorescent tags or nucleic acids — opening up applications in cancer and gene therapy.

Furthermore, these chemically modified carbon nanotubes can pierce the cell membrane, acting as a kind of ‘nano-needle’, allowing the possibility of efficient transport of therapeutic and diagnostic agents directly into the cytoplasm of cells.

Among their downsides however, have been concerns about their safety profile. One of the most serious concerns, highlighted in 2008, involves the carcinogenic risk from the exposure and persistence of such fibres in the body. Some studies indicate that when long untreated carbon nanotubes are injected to the abdominal cavity of mice they can induce unwanted responses resembling those associated with exposure to certain asbestos fibres.

In this paper, the authors describe two different reactions which ask if any chemical modification can render the nanotubes non-toxic. They conclude that not all chemical treatments alleviate the toxicity risks associated with the material. Only those reactions that are able to render carbon nanotubes short and stably suspended in biological fluids without aggregation are able to result in safe, risk-free material.

Here’s a citation and link for this latest  research, from the ScienceDaily news item where you can also read the lead researcher’s comments about carbon nanotubes, safety, and unreasonable proposals to halt production,

Hanene Ali-Boucetta, Antonio Nunes, Raquel Sainz, M. Antonia Herrero, Bowen Tian, Maurizio Prato, Alberto Bianco, Kostas Kostarelos. Asbestos-like Pathogenicity of Long Carbon Nanotubes Alleviated by Chemical Functionalization. Angewandte Chemie International Edition, 2013; DOI: 10.1002/anie.201207664

The article is behind a paywall. I have mentioned long carbon nanotubes and their resemblance to asbestos fibres in several posts. The  Oct. 26, 2009 posting [scroll down about 1/3 of the way] highlights research which took place after the study where mice had carbon nanotubes injected into their bellies; in this second piece of research they inhaled the nanotubes.

ETA Jan. 21, 2013: Dexter Johnson gives context and commentary about this latest research into long multiwalled nanotubes (MWNTs) which he sums up as the answer to this question “What if you kept the MWNTs short?”  in a Jan. 18, 2013 posting on his Nanoclast blog (on the IEEE [Institute of Electrical and Electronics Engineers] website)

FrogHeart’s 2012, a selective roundup of my international online colleagues, and other bits

Monday, December 31st, 2012

This blog will be five years old in April 2013 and, sometime in January or February, the 2000th post will be published.

Statisticswise it’s been a tumultuous year for FrogHeart with ups and downs,  thankfully ending on an up note. According to my AW stats, I started with 54,920 visits in January (which was a bit of an increase over December 2011. The numbers rose right through to March 2012 when the blog registered 68,360 visits and then the numbers fell and continued to fall. At the low point, this blog registered 45, 972 visits in June 2012 and managed to rise and fall through to Oct. 2012 when the visits rose to 54,520 visits. November 2012 was better with 66,854 visits and in December 2012 the blog will have received over 75,000 visits. (ETA Ja.2.13: This blog registered 81,0036 in December 2012 and an annual total of 681,055 visits.) Since I have no idea why the numbers fell or why they rose again, I have absolutely no idea what 2013 will bring in terms of statistics (the webalizer numbers reflect similar trends).

Interestingly and for the first time since I’ve activated the AW statistics package in Feb. 2009, the US ceased to be the primary source for visitors. As of April 2012, the British surged ahead for several months until November 2012 when the US regained the top spot only to lose it to China in December 2012.

Favourite topics according to the top 10 key terms included: nanocrystalline cellulose for Jan. – Oct. 2012 when for the first time in almost three years the topic fell out of the top 10; Jackson Pollock and physics also popped up in the top 10 in various months throughout the year; Clipperton Island (a sci/art project) has made intermittent appearances; SPAUN (Semantic Pointer Arichitecture Unified Network; a project at the University of Waterloo) has made the top 10 in the two months since it was announced); weirdly, frogheart.ca has appeared in the top 10 these last few months; the Lycurgus Cup, nanosilver, and literary tattoos also made appearances in the top 10 in various months throughout the year, while the memristor and Québec nanotechnology made appearances in the fall.

Webalizer tells a similar but not identical story. The numbers started with 83, 133 visits in January 2012 rising to a dizzying height of 119, 217 in March.  These statistics fell too but July 2012 was another six figure month with 101,087 visits and then down again to five figures until Oct. 2012 with 108, 266 and 136,161 visits in November 2012. The December 2012 visits number appear to be dipping down slightly with 130,198 visits counted to 5:10 am PST, Dec. 31, 2012. (ETA Ja.2.13: In December 2012, 133,351 were tallied with an annual total of 1,660,771 visits.)

Thanks to my international colleagues who inspire and keep me apprised of the latest information on nanotechnology and other emerging technologies:

  • Pasco Phronesis, owned by David Bruggeman, focuses more on science policy and science communicati0n (via popular media) than on emerging technology per se but David provides excellent analysis and a keen eye for the international scene. He kindly dropped by frogheart.ca  some months ago to challenge my take on science and censorship in Canada and I have not finished my response. I’ve posted part 1 in the comments but have yet to get to part 2. His latest posting on Dec. 30, 2012 features this title, For Better Science And Technology Policing, Don’t Forget The Archiving.
  • Nanoclast is on the IEEE (Institute of Electrical and Electronics Engineers) website and features Dexter Johnson’s writing on nanotechnology government initiatives, technical breakthroughs, and, occasionally, important personalities within the field. I notice Dexter, who’s always thoughtful and thought-provoking, has cut back to a weekly posting. I encourage you to read his work as he fills in an important gap in a lot of nanotechnology reporting with his intimate understanding of the technology itself.  Dexter’s Dec. 20, 2012 posting (the latest) is titled, Nanoparticle Coated Lens Converts Light into Sound for Precise Non-invasive Surgery.
  • Insight (formerly TNTlog) is Tim Harper’s (CEO of Cientifica) blog features an international perspective (with a strong focus on the UK scene) on emerging technologies and the business of science. His writing style is quite lively (at times, trenchant) and it reflects his long experience with nanotechnology and other emerging technologies. I don’t know how he finds the time and here’s his latest, a Dec. 4, 2012 posting titled, Is Printable Graphene The Key To Widespread Applications?
  • 2020 Science is Dr. Andrew Maynard’s (director of University of Michigan’s Risk Science Center) more or less personal blog. An expert on nanotechnology (he was the Chief Science Adviser for the Project on Emerging Nanotechnologies, located in Washington, DC), Andrew writes extensively about risk, uncertainty, nanotechnology, and the joys of science. Over time his blog has evolved to include the occasional homemade but science-oriented video, courtesy of one of his children. I usually check Andrew’s blog when there’s a online nanotechnology kerfuffle as he usually has the inside scoop. His latest posting on Dec. 23, 2012 features this title, On the benefits of wearing a hat while dancing naked, and other insights into the science of risk.
  • Andrew also produces and manages the Mind the Science Gap blog, which is a project encouraging MA students in the University of Michigan’s Public Health Program to write. Andrew has posted a summary of the last semester’s triumphs titled, Looking back at another semester of Mind The Science Gap.
  • NanoWiki is, strictly speaking, not a blog but the authors provide the best compilation of stories on nanotechnology issues and controversies that I have found yet. Here’s how they describe their work, “NanoWiki tracks the evolution of paradigms and discoveries in nanoscience and nanotechnology field, annotates and disseminates them, giving an overall view and feeds the essential public debate on nanotechnology and its practical applications.” There are also Spanish, Catalan, and mobile versions of NanoWiki. Their latest posting, dated  Dec. 29, 2012, Nanotechnology shows we can innovate without economic growth, features some nanotechnology books.
  • In April 2012, I was contacted by Dorothée Browaeys about a French blog, Le Meilleur Des Nanomondes. Unfortunately, there doesn’t seem to have been much action there since Feb. 2010 but I’m delighted to hear from my European colleagues and hope to hear more from them.

Sadly, there was only one interview here this year but I think they call these things ‘a big get’ as the interview was with Vanessa Clive who manages the nanotechnology portfolio at Industry Canada. I did try to get an interview with Dr. Marie D’Iorio, the new Executive Director of Canada’s National Institute of Nanotechnology (NINT; BTW, the National Research Council has a brand new site consequently [since the NINT is a National Research Council agency, so does the NINT]), and experienced the same success I had with her predecessor, Dr. Nils Petersen.

I attended two conferences this year, S.NET (Society for the Study of Nanoscience and Emerging Technologies) 2012 meeting in Enschede, Holland where I presented on my work on memristors, artificial brains, and pop culture. The second conference I attended was in Calgary where I  moderated a panel I’d organized on the topic of Canada’s science culture and policy for the 2012 Canadian Science Policy Conference.

There are a few items of note which appeared on the Canadian science scene. ScienceOnlineVancouver emerged in April 2012. From the About page,

ScienceOnlineVancouver is a monthly discussion series exploring how online communication and social media impact current scientific research and how the general public learns about it. ScienceOnlineVancouver is an ongoing discussion about online science, including science communication and available research tools, not a lecture series where scientists talk about their work. Follow the conversation on Twitter at @ScioVan, hashtag is #SoVan.

The concept of these monthly meetings originated in New York with SoNYC @S_O_NYC, brought to life by Lou Woodley (@LouWoodley, Communities Specialist at Nature.com) and John Timmer (@j_timmer, Science Editor at Ars Technica). With the success of that discussion series, participation in Scio2012, and the 2012 annual meeting of the AAAS in Vancouver, Catherine Anderson, Sarah Chow, and Peter Newbury were inspired to bring it closer to home, leading to the beginning of ScienceOnlineVancouver.

ScienceOnlineVancouver is part of the ScienceOnlineNOW community that includes ScienceOnlineBayArea, @sciobayarea and ScienceOnlineSeattle, @scioSEA. Thanks to Brian Glanz of the Open Science Federation and SciFund Challenge and thanks to Science World for a great venue.

I have mentioned the arts/engineering festival coming up in Calgary, Beakerhead, a few times but haven’t had occasion to mention Science Rendezvous before. This festival started in Toronto in 2008 and became a national festival in 2012 (?). Their About page doesn’t describe the genesis of the ‘national’ aspect to this festival as clearly as I would like. They seem to be behind with their planning as there’s no mention of the 2013 festival,which should be coming up in May.

The twitter (@frogheart) feed continues to grow in both (followed and following) albeit slowly. I have to give special props to @carlacap, @cientifica, & @timharper for their mentions, retweets, and more.

As for 2013, there are likely to be some changes here; I haven’t yet decided what changes but I will keep you posted. Have a lovely new year and I wish you all the best in 2013.

Breakthroughs with self-assembling DNA-based nanoscaled structures

Wednesday, December 19th, 2012

With all the talk about self-assembling DNA nanotechnology, it’s possible to misunderstand the stage of development this endeavour occupies as the title, Reality check for DNA Nanotechnology, for a Dec. 13, 2012 news release on EurekAlert suggests,

… This emerging technology employs DNA as a programmable building material for self-assembled, nanometer-scale structures. Many practical applications have been envisioned, and researchers recently demonstrated a synthetic membrane channel made from DNA. Until now, however, design processes were hobbled by a lack of structural feedback. Assembly was slow and often of poor quality.

In fact, the news release is touting two breakthroughs,

Now researchers led by Prof. Hendrik Dietz of the Technische Universitaet Muenchen (TUM) have removed these obstacles.

One barrier holding the field back was an unproven assumption. Researchers were able to design a wide variety of discrete objects and specify exactly how DNA strands should zip together and fold into the desired shapes. They could show that the resulting nanostructures closely matched the designs. Still lacking, though, was the validation of the assumed subnanometer-scale precise positional control. This has been confirmed for the first time through analysis of a test object designed specifically for the purpose. A technical breakthrough based on advances in fundamental understanding, this demonstration has provided a crucial reality check for DNA nanotechnology.

In a separate set of experiments, the researchers discovered that the time it takes to make a batch of complex DNA-based objects can be cut from a week to a matter of minutes, and that the yield can be nearly 100%. They showed for the first time that at a constant temperature, hundreds of DNA strands can fold cooperatively to form an object — correctly, as designed — within minutes. Surprisingly, they say, the process is similar to protein folding, despite significant chemical and structural differences. “Seeing this combination of rapid folding and high yield,” Dietz says, “we have a stronger sense than ever that DNA nanotechnology could lead to a new kind of manufacturing, with a commercial, even industrial future.” And there are immediate benefits, he adds: “Now we don’t have to wait a week for feedback on an experimental design, and multi-step assembly processes have suddenly become so much more practical.”

Dexter Johnson comments in his Dec. 18, 2012 posting (which includes an embedded video) on the Nanoclast blog (located on the Institute of Electrical and Electronics Engineers [IEEE] website),

The field of atomically precise manufacturing—or molecular manufacturing—has taken a big step towards realizing its promise with this latest research.  We may still be a long way from realizing the “nanotech rapture”  but certainly knowing that the objects built meet their design specifications and can be produced in minutes rather than weeks has to be recognized as a significant development.

Three papers have been published on these breakthroughs, here are the citations,

Xiao-chen Bai, Thomas G. Martin, Sjors H. W. Scheres, Hendrik Dietz. Cryo-EM structure of a 3D DNA-origami object. Proceedings of the National Academy of Sciences of the USA, Dec. 4, 2012, 109 (49) 20012-20017; on-line in PNAS Early Edition, Nov. 19, 2012. DOI: 10.1073/pnas.1215713109

Jean-Philippe J. Sobczak, Thomas G. Martin, Thomas Gerling, Hendrik Dietz. Rapid folding of DNA into nanoscale shapes at constant temperature. Science, vol. 338, issue 6113, pp. 1458-1461. DOI: 10.1126/science.1229919

See also: Martin Langecker, Vera Arnaut, Thomas G. Martin, Jonathan List, Stephan Renner, Michael Mayer, Hendrik Dietz, and Friedrich C. Simmel. Synthetic lipid membrane channels formed by designed DNA nanostructures. Science, vol. 338, issue 6109, pp. 932-936. DOI: 10.1126/science.1225624

Mad about Madder in lithium-ion batteries

Wednesday, December 12th, 2012

It hasn’t happened yet but it looks like the future might hold greener lithium-ion (Li-ion) batteries. According to the Dec. 11, 2012 news release on EurekAlert,

Scientists at Rice University and the City College of New York have discovered that the madder plant, aka Rubia tinctorum, is a good source of purpurin, an organic dye that can be turned into a highly effective, natural cathode for lithium-ion batteries. The plant has been used since ancient times to create dye for fabrics.

The goal, according to lead author Arava Leela Mohana Reddy, a research scientist in the Rice lab of materials scientist Pulickel Ajayan, is to create environmentally friendly batteries that solve many of the problems with lithium-ion batteries in use today.

Purpurin, left, extracted from madder root, center, is chemically lithiated, right, for use as an organic cathode in batteries. The material was developed as a less expensive, easier-to-recycle alternative to cobalt oxide cathodes now used in lithium-ion batteries. Credit: Ajayan Lab/Rice University

The Dec. 11, 2012 Rice University news release by Mike Williams, the origin for the one on EurekAlert, describes why the researchers are so interested in a more environmentally-friendly cathode,

While lithium-ion batteries have become standard in conventional electronics since their commercial introduction in 1991, the rechargeable units remain costly to manufacture, Reddy said. “They’re not environmentally friendly. They use cathodes of lithium cobalt oxide, which are very expensive. You have to mine the cobalt metal and manufacture the cathodes in a high-temperature environment. There are a lot of costs.

“And then, recycling is a big issue,” he said. “In 2010, almost 10 billion lithium-ion batteries had to be recycled, which uses a lot of energy. Extracting cobalt from the batteries is an expensive process.”

Reddy and his colleagues came across purpurin while testing a number of organic molecules for their ability to electrochemically interact with lithium and found purpurin most amenable to binding lithium ions. With the addition of 20 percent carbon to add conductivity, the team built a half-battery cell with a capacity of 90 milliamp hours per gram after 50 charge/discharge cycles. The cathodes can be made at room temperature, he said.

“It’s a new mechanism we are proposing with this paper, and the chemistry is really simple,” Reddy said. He suggested agricultural waste may be a source of purpurin, as may other suitable molecules, which makes the process even more economical.

Innovation in the battery space is needed to satisfy future demands and counter environmental issues like waste management, “and hence we are quite fascinated by the ability to develop alternative electrode technologies to replace conventional inorganic materials in lithium-ion batteries,” said Ajayan, Rice’s Benjamin M. and Mary Greenwood Anderson Professor in Mechanical Engineering and Materials Science and of chemistry.

“We’re interested in developing value-added chemicals, products and materials from renewable feedstocks as a sustainable technology platform,” said co-lead author George John, a professor of chemistry at the City College of New York-CUNY and an expert on bio-based materials and green chemistry. “The point has been to understand the chemistry between lithium ions and the organic molecules. Now that we have that proper understanding, we can tap other molecules and improve capacity.”

For anyone who’s interested, you can read the researchers’ article (open access),

Lithium storage mechanisms in purpurin based organic lithium ion battery electrodes by Arava Leela Mohana Reddy,  Subbiah Nagarajan, Porramate Chumyim, Sanketh R. Gowda, Padmanava Pradhan, Swapnil R. Jadhav, Madan Dubey,  George John & Pulickel M. Ajayan in Scientific Reports 2 Article number: 960 doi:10.1038/srep00960

You might also want to check out Dexter Johnson’s Nov. 26, 2012 posting (on Nanoclast, an IEEE [Institute of Electrical and Electronics Engineers] blog)where he mentions a technical deficiency (recharging becomes increasingly difficult) with the current Li-ion batteries in the context of his description of a new imaging technique.

Wanxiang America wins bid for most of A123 Systems’ assets

Monday, December 10th, 2012

The A123 Systems, Inc., a manufacturer of lithium-ion (Li-ion) batteries, story takes a few more twists and turns. The company declared bankruptcy in Oct. 2012 and announced that it had entered an asset purchase agreement with Johnson Controls. From the A123 Systems About Us webpage,

Asset Purchase Agreement and Chapter 11 Information

On October 16, 2012, A123 Systems, Inc. announced that it has entered into an asset purchase agreement with Johnson Controls, Inc., which plans to acquire A123’s automotive business assets, including all of its automotive technology, products and customer contracts, its facilities in Livonia and Romulus, Mich., its cathode powder manufacturing facilities in China, and A123′s equity interest in Shanghai Advanced Traction Battery Systems Co., Alpha’s joint venture with Shanghai Automotive. The asset purchase agreement also includes provisions through which Johnson Controls intends to license back to A123 certain technology for its grid, commercial and government businesses.

Today, Dec. 10, 2012, there’s a news item on Azonano about A123 Systems’ assets being acquired by Wangxiang America,

A123 Systems, Inc., a developer and manufacturer of advanced Nanophosphate® lithium iron phosphate batteries and systems, today announced that it has reached agreement on the terms of an asset purchase agreement with Wanxiang America Corporation (“Wanxiang”) through which Wanxiang would acquire substantially all of A123’s assets for $256.6 million.

The agreement was reached following an auction conducted under the supervision of the United States Bankruptcy Court for the District of Delaware (the “Court”). A hearing at which A123 and Wanxiang will seek the required Court approval of the sale is scheduled for Tuesday, December 11, 2012.

According to the terms of the asset purchase agreement, Wanxiang would acquire A123’s automotive, grid and commercial business assets, including all technology, products, customer contracts and U.S. facilities in Michigan, Massachusetts and Missouri; its cathode powder manufacturing operations in China; and its equity interest in Shanghai Advanced Traction Battery Systems Co., A123’s joint venture with Shanghai Automotive. Excluded from the asset purchase agreement with Wanxiang is A123’s Ann Arbor, Mich.-based government business, including all U.S. military contracts, which would be acquired for $2.25 million by Navitas Systems, a Woodridge, Ill.-based provider of energy-enabled system solutions and energy storage products for commercial, industrial and government agency customers.

The Oct. 2012 deal with Johnson Controls seems to have collapsed, which occasioned this December 2012 auction in which Johnson Controls did participate initially. From the Dec. 9, 2012 Johnson Controls news release on PR Newswire,

Johnson Controls officially withdrew from the bankruptcy auction to acquire portions of A123 Systems when it declined to match a higher bid submitted by Wanxiang.  Subsequently A123 representatives have announced they selected Wanxiang’s bid of $257 million as the best offer for the total company over a set of competing complementary bids by Johnson Controls for the automotive and government assets and NEC for the grid and commercial assets.

“While A123′s automotive and government assets were complementary to Johnson Controls’ portfolio and aligned with our long-term goals, Wanxiang’s offer was beyond the value of those assets to Johnson Controls,” said Alex Molinaroli, president, Johnson Controls Power Solutions. “Reports by other parties that our proposal involved an elimination of jobs in Michigan are inaccurate.”

The Dec. 10, 2012 news article on Bloomberg Businessweek website provides more detail and some analysis,

Wanxiang is seeking A123’s battery technology, used in Fisker Automotive Inc.’s Karma sedan, as China pushes its companies to develop electric vehicles. An earlier accord with the Chinese company was scrapped in October, when A123 said it filed for bankruptcy protection and agreed to sell its automotive assets to Johnson Controls.

“The purchase of A123 would automatically vault Wanxiang to become probably the number one battery maker in China,” said Shu Sun, a Beijing-based analyst at Bloomberg New Energy Finance. “Technology-wise, no battery company in China is likely to match A123’s products in performance and reliability.”

A123 supplies electric-car batteries to a dozen customers, according Bloomberg New Energy Finance estimates. That’s the highest number of clients in the industry, though LG Chem Ltd. and NEC Corp. (6701)’s venture with Leaf-maker Nissan Motor Co. have higher volume sales, Sun said.

Wanxiang Qianchao Co. (000559), a listed unit of the closely held parent advanced 1.4 percent to 4.25 yuan in Shenzhen trading today, narrowing its loss for the year to 25 percent.

The auction results also pave the way for Hangzhou, China- based Wanxiang to receive A123’s cathode powder plant in China and its share of a joint venture with Shanghai Automotive Industry Corp. called Shanghai Advanced Traction Battery Systems Co., according to yesterday’s statement.

Navitas Systems, a Woodridge, Illinois-based company, will buy A123’s Ann Arbor, Michigan-based government business for $2.25 million, according to the statement.

A123, the recipient of a $249.1 million federal grant, held the auction behind closed doors in the Chicago law offices of Latham & Watkins. The auction began on Dec. 6 with prospective bidders including Johnson Controls, Wanxiang, Siemens AG (SIE) of Germany and Tokyo-based NEC Corp.

As to the why and how of A123 Systems’ bankruptcy in the first place, Dexter Johnson in his Oct. 17, 2012 posting on Nanoclast (on the IEEE [Institute of Electrical and Electronics Engineers] website) suggests it had to do with old fashioned supply and demand economics,

The underlying problems of A123 Systems, Solyndra, and Konarka are not political ones of governmental policies—they’re illustrations of the futility of ignoring good old-fashioned supply-and-demand economics. (Solyndra, besides never being competitive with traditional energy sources, was also forced to compete with heavily subsidized solar alternatives.)

There is little question that A123 Systems made a better Li-ion battery than its competitors. The problem was the nano-enabled battery that they came up with for powering electric vehicles (EVs) was not in competition with other Li-ion batteries, but with the internal combustion engine.

This is not a political issue or an ideological issue, it’s a numbers issue. …

Dexter mentions A123 Systems again in an Oct. 19, 2012 posting (Nanotechnology As Socio-Political Project), featuring a broader analysis of the issues around commercializing technologies. There’s a thesis in here for someone.

ETA Dec. 13, 2012: The US Bankruptcy Court for the District of Delaware has approved the sale of A123 Systems’ military business to Navitas according to a Dec. 13, 2012 news item on Azonano,

Navitas Systems LLC, a leading provider of energy-enabled system solutions and energy storage products for commercial, industrial and government agency customers, today announced that the United States Bankruptcy Court for the District of Delaware (the “Court”) has approved the sale of A123 Systems’ Ann Arbor, Mich.-based government business, including all U.S. military contracts, for $2.3 million to Navitas. …

Navitas Systems can be found here.