Researchers at the King Adbullah University of Science and Technology (KAUST) are developing sensors made of household materials according to a Feb. 19, 2016 KAUST news release (also on EurekAlert but dated Feb. 21, 2016),
Everyday materials from the kitchen drawer, such as aluminum foil, sticky note paper, sponges and tape, have been used by a team of electrical engineers from KAUST to develop a low-cost sensor that can detect external stimuli, including touch, pressure, temperature, acidity and humidity.
The sensor, which is called Paper Skin, performs as well as other artificial skin applications currently being developed while integrating multiple functions using cost-effective materials1.
“This work has the potential to revolutionize the electronics industry and opens the door to commercializing affordable high-performance sensing devices,” stated Muhammad Mustafa Hussain from the University’s Integrated Nanotechnology Lab, where the research was conducted.
Wearable and flexible electronics show promise for a variety of applications, such as wireless monitoring of patient health and touch-free computer interfaces. Current research in this direction employs expensive and sophisticated materials and processes.
The team used sticky note paper to detect humidity, sponges and wipes to detect pressure and aluminum foil to detect motion. Coloring a sticky note with an HB pencil allowed the paper to detect acidity levels, and aluminum foil and conductive silver ink were used to detect temperature differences.
The materials were put together into a simple paper-based platform that was then connected to a device that detected changes in electrical conductivity according to external stimuli.
Increasing levels of humidity, for example, increased the platform’s ability to store an electrical charge, or its capacitance. Exposing the sensor to an acidic solution increased its resistance, while exposing it to an alkaline solution decreased it. Voltage changes were detected with temperature changes. Bringing a finger closer to the platform disturbed its electromagnetic field, decreasing its capacitance.
The team leveraged the various properties of the materials they used, including their porosity, adsorption, elasticity and dimensions to develop the low-cost sensory platform. They also demonstrated that a single integrated platform could simultaneously detect multiple stimuli in real time.
Several challenges must be overcome before a fully autonomous, flexible and multifunctional sensory platform becomes commercially achievable, explained Hussain. Wireless interaction with the paper skin needs to be developed. Reliability tests also need to be conducted to assess how long the sensor can last and how good its performance is under severe bending conditions.
“The next stage will be to optimize the sensor’s integration on this platform for applications in medical monitoring systems. The flexible and conformal sensory platform will enable simultaneous real-time monitoring of body vital signs, such as heart rate, blood pressure, breathing patterns and movement,” Hussain said.
Any work which features a scientist chewing gum preparatory to using it for research purposes should be widely disseminated. In all the talk about science and equipment, it’s easy to forget that scientists are capable of great ingenuity with simple, every day materials. Also, the researchers are Canadian and based at the University of Manitoba. From a Dec. 2, 2015 American Chemical Society (ACS) news release (also on EurekAlert),
Body sensors, which were once restricted to doctors’ offices, have come a long way. They now allow any wearer to easily track heart rate, steps and sleep cycles around the clock. Soon, they could become even more versatile — with the help of chewing gum. Scientists report in the journal ACS Applied Materials & Interfaces a unique sensing device made of gum and carbon nanotubes that can move with your most bendable parts and track your breathing.
Most conventional sensors today are very sensitive and detect the slightest movement, but many are made out of metal. That means when they’re twisted or pulled too much, they stop working. But for sensors to monitor the full range of a body’s bending and stretching, they need a lot more give. To meet that need, some researchers have tried developing sensors using stretchy plastics and silicones. But what they gained in flexibility, they lost in sensitivity. Malcolm Xing and colleagues found a better solution right under their noses — and in their mouths.
To make their supple sensor, a team member chewed a typical piece of gum for 30 minutes, washed it with ethanol and let it sit overnight. The researchers then added a solution of carbon nanotubes, the sensing material. Simple pulling and folding coaxed the tubes to align properly. Human finger-bending and head-turning tests showed the material could keep working with high sensitivity even when strained 530 percent. The sensor also could detect humidity changes, a feature that could be used to track breathing, which releases water vapor with every exhale.
Wearable technology seems to be quite trendy for a grouping not usually seen: consumers, fashion designers, medical personnel, manufacturers, and scientists.
The first in this informal series concerns a fibre with memory shape. From a Nov. 19, 2015 news item on Nanowerk (Note: A link has been removed),
Wearing your mobile phone display on your jacket sleeve or an EKG probe in your sports kit are not off in some distant imagined future. Wearable “electronic textiles” are on the way. In the journal Angewandte Chemie (“A Shape-Memory Supercapacitor Fiber”), Chinese researchers have now introduced a new type of fiber-shaped supercapacitor for energy-storage textiles. Thanks to their shape memory, these textiles could potentially adapt to different body types: shapes formed by stretching and bending remain “frozen”, but can be returned to their original form or reshaped as desired.
Any electronic components designed to be integrated into textiles must be stretchable and bendable. This is also true of the supercapacitors that are frequently used for data preservation in static storage systems (SRAM). SRAM is a type of storage that holds a small amount of data that is rapidly retrievable. It is often used for caches in processors or local storage on chips in devices whose data must be stored for long periods without a constant power supply. Some time ago, a team headed by Huisheng Peng at Fudan University developed stretchable, pliable fiber-shaped supercapacitors for integration into electronic textiles. Peng and his co-workers have now made further progress: supercapacitor fibers with shape memory.
Any electronic components designed to be integrated into textiles must be stretchable and bendable. This is also true of the supercapacitors that are frequently used for data preservation in static storage systems (SRAM). SRAM is a type of storage that holds a small amount of data that is rapidly retrievable. It is often used for caches in processors or local storage on chips in devices whose data must be stored for long periods without a constant power supply.
Some time ago, a team headed by Huisheng Peng at Fudan University developed stretchable, pliable fiber-shaped supercapacitors for integration into electronic textiles. Peng and his co-workers have now made further progress: supercapacitor fibers with shape memory.
The fibers are made using a core of polyurethane fiber with shape memory. This fiber is wrapped with a thin layer of parallel carbon nanotubes like a sheet of paper. This is followed by a coating of electrolyte gel, a second sheet of carbon nanotubes, and a final layer of electrolyte gel. The two layers of carbon nanotubes act as electrodes for the supercapacitor. Above a certain temperature, the fibers produced in this process can be bent as desired and stretched to twice their original length. The new shape can be “frozen” by cooling. Reheating allows the fibers to return to their original shape and size, after which they can be reshaped again. The electrochemical performance is fully maintained through all shape changes.
Weaving the fibers into tissues results in “smart” textiles that could be tailored to fit the bodies of different people. This could be used to make precisely fitted but reusable electronic monitoring systems for patients in hospitals, for example. The perfect fit should render them both more comfortable and more reliable.
Here’s a link to and a citation for the paper,
A Shape-Memory Supercapacitor Fiber by Jue Deng, Ye Zhang, Yang Zhao, Peining Chen, Dr. Xunliang Cheng, & Prof. Dr. Huisheng Peng. Angewandte Chemie International Edition DOI: 10.1002/anie.201508293 First published: 3 November 2015
Glass is notorious for its brittleness. Although industry has developed ultra-thin (∼0.1 mm), flexible glass (like Corning’s Willow® Glass) that can be bent for applications liked curved TV and smartphone displays, fully foldable glass had not been demonstrated. Until now.
Khang [Dahl-Young Khang, an Associate Professor in the Department of Materials Science and Engineering at Yonsei University] and his group have now demonstrated substrate platforms of glass and plastics, which can be reversibly and repeatedly foldable at pre designed location(s) without any mechanical failure or deterioration in device performances.
“We have engineered the substrates to have thinned parts on which the folding deformation should occur,” Moon Jong Han, first author of the paper a graduate student in Khang’s lab, says. “This localizes the deformation strain on those thinned parts only.”
He adds that this approach to engineering substrates has another advantage regarding device materials: “There is no need to adopt any novel materials such as nanowires, carbon nanotubes, graphene, etc. Rather, all the conventional materials that have been used for high-performance devices can be directly applied on our engineered substrates.”
Intriguingly, even ITO (indium tin oxide), a very brittle transparent conducting oxide, can be used as electrode on this novel foldable glass platform.
What makes the approach especially intriguing is the ability to reverse the fold and that it doesn’t require special nanomaterials, such as carbon nanotubes, etc. From Berger’s Aug. 11, 2015 article,
The width of the thinned parts, the gap width, plays the key role in implementing dual foldability. The other key element is the asymmetric design of the gap width for the second folding.
The researchers achieved foldability, in part, by copying a technique used for folding mats and oriental hinge-less screens which have thinned areas to allow folding.
Technology experts have long predicted the coming age of flexible electronics, and researchers have been working on multiple fronts to reach that goal. But many of the advances rely on petroleum-based plastics and toxic materials. Yu-Zhong Wang, Fei Song and colleagues wanted to seek a “greener” way forward.
The researchers developed a thin, clear nanocellulose paper made out of wood flour and infused it with biocompatible quantum dots — tiny, semiconducting crystals — made out of zinc and selenium. The paper glowed at room temperature and could be rolled and unrolled without cracking.
There are a lot of research teams jockeying for position in the transparent, flexible electrodes stakes (for anyone unfamiliar with the slang, I’m comparing the competition between various research teams to a horse race). A May 11, 2015 news item on Nanowerk describes work from an international collaboration at the University of Exeter (UK), Note: A link has been removed,
An international team of scientists, including Professor Monica Craciun from the University of Exeter, have pioneered a new technique to embed transparent, flexible graphene electrodes into fibres commonly associated with the textile industry.
The discovery could revolutionise the creation of wearable electronic devices, such as clothing containing computers, phones and MP3 players, which are lightweight, durable and easily transportable.
The international collaborative research, which includes experts from the Centre for Graphene Science at the University of Exeter, the Institute for Systems Engineering and Computers, Microsystems and Nanotechnology (INESC-MN) in Lisbon, the Universities of Lisbon and Aveiro in Portugal and the Belgian Textile Research Centre (CenTexBel), is published in the leading scientific journal Scientific Reports (“Transparent conductive graphene textile fibers”).
Professor Craciun, co-author of the research said: “This is a pivotal point in the future of wearable electronic devices. The potential has been there for a number of years, and transparent and flexible electrodes are already widely used in plastics and glass, for example. But this is the first example of a textile electrode being truly embedded in a yarn. The possibilities for its use are endless, including textile GPS systems, to biomedical monitoring, personal security or even communication tools for those who are sensory impaired. The only limits are really within our own imagination.”
At just one atom thick, graphene is the thinnest substance capable of conducting electricity. It is very flexible and is one of the strongest known materials. The race has been on for scientists and engineers to adapt graphene for the use in wearable electronic devices in recent years.
This new research has identified that ‘monolayer graphene’, which has exceptional electrical, mechanical and optical properties, make it a highly attractive proposition as a transparent electrode for applications in wearable electronics. In this work graphene was created by a growth method called chemical vapour deposition (CVD) onto copper foil, using a state-of-the-art nanoCVD system recently developed by Moorfield.
The collaborative team established a technique to transfer graphene from the copper foils to a polypropylene fibre already commonly used in the textile industry.
Dr Helena Alves who led the research team from INESC-MN and the University of Aveiro said: “The concept of wearable technology is emerging, but so far having fully textile-embedded transparent and flexible technology is currently non-existing. Therefore, the development of processes and engineering for the integration of graphene in textiles would give rise to a new universe of commercial applications. “
Dr Ana Neves, Associate Research Fellow in Prof Craciun’s team from Exeter’s Engineering Department and former postdoctoral researcher at INESC added: “We are surrounded by fabrics, the carpet floors in our homes or offices, the seats in our cars, and obviously all our garments and clothing accessories. The incorporation of electronic devices on fabrics would certainly be a game-changer in modern technology.
“All electronic devices need wiring, so the first issue to be address in this strategy is the development of conducting textile fibres while keeping the same aspect, comfort and lightness. The methodology that we have developed to prepare transparent and conductive textile fibres by coating them with graphene will now open way to the integration of electronic devices on these textile fibres.”
Dr Isabel De Schrijver,an expert of smart textiles from CenTexBel said: “Successful manufacturing of wearable electronics has the potential for a disruptive technology with a wide array of potential new applications. We are very excited about the potential of this breakthrough and look forward to seeing where it can take the electronics industry in the future.”
Professor Saverio Russo, co-author and also from the University of Exeter, added: “This breakthrough will also nurture the birth of novel and transformative research directions benefitting a wide range of sectors ranging from defence to health care. “
In 2012 Professor Craciun and Professor Russo, from the University of Exeter’s Centre for Graphene Science, discovered GraphExeter – sandwiched molecules of ferric chloride between two graphene layers which makes a whole new system that is the best known transparent material able to conduct electricity. The same team recently discovered that GraphExeter is also more stable than many transparent conductors commonly used by, for example, the display industry.
A revolution is coming in flexible electronic technologies as cheaper, more flexible, organic transistors come on the scene to replace expensive, rigid, silicone-based semiconductors, but not enough is known about how bending in these new thin-film electronic devices will affect their performance, say materials scientists at the University of Massachusetts Amherst.
They are the first to apply inhomogeneous deformations, that is strain, to the conducting channel of an organic transistor and to understand the observed effects, says Reyes-Martinez [Marcos Reyes-Martinez], who conducted the series of experiments as part of his doctoral work.
As he explains, “This is relevant to today’s tech industry because transistors drive the logic of all the consumer electronics we use. In the screen on your smart phone, for example, every little pixel that makes up the image is turned on and off by hundreds of thousands or even millions of miniaturized transistors.”
“Traditionally, the transistors are rigid, made of an inorganic material such as silicon,” he adds. “We’re working with a crystalline semiconductorcalled rubrene, which is an organic, carbon-based material that has performance factors, such as charge-carrier mobility, surpassing those measured in amorphous silicon. Organic semiconductors are an interesting alternative to silicon because their properties can be tuned to make them easily processed, allowing them to coat a variety of surfaces, including soft substrates at relatively low temperatures. As a result, devices based on organic semiconductors are projected to be cheaper since they do not require high temperatures, clean rooms and expensive processing steps like silicon does.”
Until now, Reyes-Martinez notes, most researchers have focused on controlling the detrimental effects of mechanical deformation to atransistor’s electrical properties. But in their series of systematic experiments, the UMass Amherst team discovered that mechanical deformations only decrease performance under certain conditions, and actually can enhance or have no effect in other instances.
“Our goal was not only to show these effects, but to explain and understand them. What we’ve done istake advantage of the ordered structure of ultra-thin organic single crystals of rubrene to fabricate high-perfomance, thin-film transistors,” he says. “This is the first time that anyone has carried out detailed fundamental work at these length scales with a single crystal.”
Though single crystals were once thought to be too fragile for flexible applications, the UMass Amherst team found that crystals ranging in thickness from about 150 nanometers to 1 micrometer were thin enough to be wrinkled and applied to any elastomer substrate. Reyes-Martinez also notes, “Our experiments are especially important because they help scientists working on flexible electronic devices to determine performance limitations of new materials under extreme mechanical deformations, such as when electronic devices conform to skin.”
They developed an analytical model based on plate bending theoryto quantifythe different local strains imposed on the transistor structure by the wrinkle deformations. Using their model they are able to predict how different deformations modulate charge mobility, which no one had quantified before, Reyes-Martinez notes.
These contributions “represent a significant step forward in structure-function relationships in organic semiconductors, critical for the development of the next generation of flexible electronic devices,” the authors point out.
A research team led by Professor Keon Jae Lee of the Department of Materials Science and Engineering at the Korea Advanced Institute of Science and Technology (KAIST) has developed a hyper-stretchable elastic-composite energy harvesting device called a nanogenerator.
Flexible electronics have come into the market and are enabling new technologies like flexible displays in mobile phone, wearable electronics, and the Internet of Things (IoTs). However, is the degree of flexibility enough for most applications? For many flexible devices, elasticity is a very important issue. For example, wearable/biomedical devices and electronic skins (e-skins) should stretch to conform to arbitrarily curved surfaces and moving body parts such as joints, diaphragms, and tendons. They must be able to withstand the repeated and prolonged mechanical stresses of stretching. In particular, the development of elastic energy devices is regarded as critical to establish power supplies in stretchable applications. Although several researchers have explored diverse stretchable electronics, due to the absence of the appropriate device structures and correspondingly electrodes, researchers have not developed ultra-stretchable and fully-reversible energy conversion devices properly.
Recently, researchers from KAIST and Seoul National University (SNU) have collaborated and demonstrated a facile methodology to obtain a high-performance and hyper-stretchable elastic-composite generator (SEG) using very long silver nanowire-based stretchable electrodes. Their stretchable piezoelectric generator can harvest mechanical energy to produce high power output (~4 V) with large elasticity (~250%) and excellent durability (over 104 cycles). These noteworthy results were achieved by the non-destructive stress- relaxation ability of the unique electrodes as well as the good piezoelectricity of the device components. The new SEG can be applied to a wide-variety of wearable energy-harvesters to transduce biomechanical-stretching energy from the body (or machines) to electrical energy.
Professor Lee said, “This exciting approach introduces an ultra-stretchable piezoelectric generator. It can open avenues for power supplies in universal wearable and biomedical applications as well as self-powered ultra-stretchable electronics.”
Here’s a link to and a citation for the paper,
A Hyper-Stretchable Elastic-Composite Energy Harvester by Chang Kyu Jeong, Jinhwan Lee, Seungyong Han, Jungho Ryu, Geon-Tae Hwang, Dae Yong Park, Jung Hwan Park, Seung Seob Lee, Mynghwan Byun, Seung Hwan Ko, and Keon Jae Lee. Advanced Materials DOI: 10.1002/adma.201500367 30 March 2015Full
This paper is behind a paywall.
The researchers have prepared a short video (22 secs. and silent),
This research comes from Purdue University (Indiana, US) which seems to be on a publishing binge these days. From an April 7, 2015 news item on Nanowerk,
New research shows how inkjet-printing technology can be used to mass-produce electronic circuits made of liquid-metal alloys for “soft robots” and flexible electronics.
Elastic technologies could make possible a new class of pliable robots and stretchable garments that people might wear to interact with computers or for therapeutic purposes. However, new manufacturing techniques must be developed before soft machines become commercially feasible, said Rebecca Kramer, an assistant professor of mechanical engineering at Purdue University.
“We want to create stretchable electronics that might be compatible with soft machines, such as robots that need to squeeze through small spaces, or wearable technologies that aren’t restrictive of motion,” she said. “Conductors made from liquid metal can stretch and deform without breaking.”
A new potential manufacturing approach focuses on harnessing inkjet printing to create devices made of liquid alloys.
“This process now allows us to print flexible and stretchable conductors onto anything, including elastic materials and fabrics,” Kramer said.
A research paper about the method will appear on April 18  in the journal Advanced Materials. The paper generally introduces the method, called mechanically sintered gallium-indium nanoparticles, and describes research leading up to the project. It was authored by postdoctoral researcher John William Boley, graduate student Edward L. White and Kramer.
A printable ink is made by dispersing the liquid metal in a non-metallic solvent using ultrasound, which breaks up the bulk liquid metal into nanoparticles. This nanoparticle-filled ink is compatible with inkjet printing.
“Liquid metal in its native form is not inkjet-able,” Kramer said. “So what we do is create liquid metal nanoparticles that are small enough to pass through an inkjet nozzle. Sonicating liquid metal in a carrier solvent, such as ethanol, both creates the nanoparticles and disperses them in the solvent. Then we can print the ink onto any substrate. The ethanol evaporates away so we are just left with liquid metal nanoparticles on a surface.”
After printing, the nanoparticles must be rejoined by applying light pressure, which renders the material conductive. This step is necessary because the liquid-metal nanoparticles are initially coated with oxidized gallium, which acts as a skin that prevents electrical conductivity.
“But it’s a fragile skin, so when you apply pressure it breaks the skin and everything coalesces into one uniform film,” Kramer said. “We can do this either by stamping or by dragging something across the surface, such as the sharp edge of a silicon tip.”
The approach makes it possible to select which portions to activate depending on particular designs, suggesting that a blank film might be manufactured for a multitude of potential applications.
“We selectively activate what electronics we want to turn on by applying pressure to just those areas,” said Kramer, who this year was awarded an Early Career Development award from the National Science Foundation, which supports research to determine how to best develop the liquid-metal ink.
The process could make it possible to rapidly mass-produce large quantities of the film.
Future research will explore how the interaction between the ink and the surface being printed on might be conducive to the production of specific types of devices.
“For example, how do the nanoparticles orient themselves on hydrophobic versus hydrophilic surfaces? How can we formulate the ink and exploit its interaction with a surface to enable self-assembly of the particles?” she said.
The researchers also will study and model how individual particles rupture when pressure is applied, providing information that could allow the manufacture of ultrathin traces and new types of sensors.
I have two items about implants and brains and an item about being able to exert remote control of the brain, all of which hint at a cyborg future for at least a few of us.
e-Dura, the spinal column, and the brain
The first item concerns some research, at the École Polytechnique de Lausanne (EPFL) which features flexible electronics. From a March 24, 2015 article by Ben Schiller for Fast Company (Note: Links have been removed),
Researchers at the Swiss Federal Institute of Technology, in Lausanne, have developed the e-Dura—a tiny skinlike device that attaches directly to damaged spinal cords. By sending out small electrical pulses, it stimulates the cord as if it were receiving signals from the brain, thus allowing movement.
“The purpose of the neuro-prosthesis is to excite the neurons that are on the spinal cord below the site of the injury and activate them, just like if they were receiving information from the brain,” says Stéphanie Lacour, a professor at the institute.
EPFL scientists have managed to get rats walking on their own again using a combination of electrical and chemical stimulation. But applying this method to humans would require multifunctional implants that could be installed for long periods of time on the spinal cord without causing any tissue damage. This is precisely what the teams of professors Stéphanie Lacour and Grégoire Courtine have developed. Their e-Dura implant is designed specifically for implantation on the surface of the brain or spinal cord. The small device closely imitates the mechanical properties of living tissue, and can simultaneously deliver electric impulses and pharmacological substances. The risks of rejection and/or damage to the spinal cord have been drastically reduced. An article about the implant will appear in early January  in Science Magazine.
So-called “surface implants” have reached a roadblock; they cannot be applied long term to the spinal cord or brain, beneath the nervous system’s protective envelope, otherwise known as the “dura mater,” because when nerve tissues move or stretch, they rub against these rigid devices. After a while, this repeated friction causes inflammation, scar tissue buildup, and rejection.
Here’s what the implant looks like,
The press release describes how the implant is placed (Note: A link has been removed),
Flexible and stretchy, the implant developed at EPFL is placed beneath the dura mater, directly onto the spinal cord. Its elasticity and its potential for deformation are almost identical to the living tissue surrounding it. This reduces friction and inflammation to a minimum. When implanted into rats, the e-Dura prototype caused neither damage nor rejection, even after two months. More rigid traditional implants would have caused significant nerve tissue damage during this period of time.
The researchers tested the device prototype by applying their rehabilitation protocol — which combines electrical and chemical stimulation – to paralyzed rats. Not only did the implant prove its biocompatibility, but it also did its job perfectly, allowing the rats to regain the ability to walk on their own again after a few weeks of training.
“Our e-Dura implant can remain for a long period of time on the spinal cord or the cortex, precisely because it has the same mechanical properties as the dura mater itself. This opens up new therapeutic possibilities for patients suffering from neurological trauma or disorders, particularly individuals who have become paralyzed following spinal cord injury,” explains Lacour, co-author of the paper, and holder of EPFL’s Bertarelli Chair in Neuroprosthetic Technology.
The press release goes on to describe the engineering achievements,
Developing the e-Dura implant was quite a feat of engineering. As flexible and stretchable as living tissue, it nonetheless includes electronic elements that stimulate the spinal cord at the point of injury. The silicon substrate is covered with cracked gold electric conducting tracks that can be pulled and stretched. The electrodes are made of an innovative composite of silicon and platinum microbeads. They can be deformed in any direction, while still ensuring optimal electrical conductivity. Finally, a fluidic microchannel enables the delivery of pharmacological substances – neurotransmitters in this case – that will reanimate the nerve cells beneath the injured tissue.
The implant can also be used to monitor electrical impulses from the brain in real time. When they did this, the scientists were able to extract with precision the animal’s motor intention before it was translated into movement.
“It’s the first neuronal surface implant designed from the start for long-term application. In order to build it, we had to combine expertise from a considerable number of areas,” explains Courtine, co-author and holder of EPFL’s IRP Chair in Spinal Cord Repair. “These include materials science, electronics, neuroscience, medicine, and algorithm programming. I don’t think there are many places in the world where one finds the level of interdisciplinary cooperation that exists in our Center for Neuroprosthetics.”
For the time being, the e-Dura implant has been primarily tested in cases of spinal cord injury in paralyzed rats. But the potential for applying these surface implants is huge – for example in epilepsy, Parkinson’s disease and pain management. The scientists are planning to move towards clinical trials in humans, and to develop their prototype in preparation for commercialization.
EPFL has provided a video of researcher Stéphanie Lacour describing e-Dura and expressing hopes for its commercialization,
Here’s a link to and a citation for the paper,
Electronic dura mater for long-term multimodal neural interfaces by Ivan R. Minev, Pavel Musienko, Arthur Hirsch, Quentin Barraud, Nikolaus Wenger, Eduardo Martin Moraud, Jérôme Gandar, Marco Capogrosso, Tomislav Milekovic, Léonie Asboth, Rafael Fajardo Torres, Nicolas Vachicouras, Qihan Liu, Natalia Pavlova, Simone Duis, Alexandre Larmagnac, Janos Vörös, Silvestro Micera, Zhigang Suo, Grégoire Courtine, Stéphanie P. Lacour. Science 9 January 2015: Vol. 347 no. 6218 pp. 159-163 DOI: 10.1126/science.1260318
This paper is behind a paywall.
Carbon nanotube fibres could connect to the brain
Researchers at Rice University (Texas, US) are excited about the possibilities that carbon nanotube fibres offer in the field of implantable electronics for the brain. From a March 25, 2015 news item on Nanowerk,
Carbon nanotube fibers invented at Rice University may provide the best way to communicate directly with the brain.
The fibers have proven superior to metal electrodes for deep brain stimulation and to read signals from a neuronal network. Because they provide a two-way connection, they show promise for treating patients with neurological disorders while monitoring the real-time response of neural circuits in areas that control movement, mood and bodily functions.
New experiments at Rice demonstrated the biocompatible fibers are ideal candidates for small, safe electrodes that interact with the brain’s neuronal system, according to the researchers. They could replace much larger electrodes currently used in devices for deep brain stimulation therapies in Parkinson’s disease patients.
They may also advance technologies to restore sensory or motor functions and brain-machine interfaces as well as deep brain stimulation therapies for other neurological disorders, including dystonia and depression, the researchers wrote.
The fibers created by the Rice lab of chemist and chemical engineer Matteo Pasquali consist of bundles of long nanotubes originally intended for aerospace applications where strength, weight and conductivity are paramount.
The individual nanotubes measure only a few nanometers across, but when millions are bundled in a process called wet spinning, they become thread-like fibers about a quarter the width of a human hair.
“We developed these fibers as high-strength, high-conductivity materials,” Pasquali said. “Yet, once we had them in our hand, we realized that they had an unexpected property: They are really soft, much like a thread of silk. Their unique combination of strength, conductivity and softness makes them ideal for interfacing with the electrical function of the human body.”
The simultaneous arrival in 2012 of Caleb Kemere, a Rice assistant professor who brought expertise in animal models of Parkinson’s disease, and lead author Flavia Vitale, a research scientist in Pasquali’s lab with degrees in chemical and biomedical engineering, prompted the investigation.
“The brain is basically the consistency of pudding and doesn’t interact well with stiff metal electrodes,” Kemere said. “The dream is to have electrodes with the same consistency, and that’s why we’re really excited about these flexible carbon nanotube fibers and their long-term biocompatibility.”
Weeks-long tests on cells and then in rats with Parkinson’s symptoms proved the fibers are stable and as efficient as commercial platinum electrodes at only a fraction of the size. The soft fibers caused little inflammation, which helped maintain strong electrical connections to neurons by preventing the body’s defenses from scarring and encapsulating the site of the injury.
The highly conductive carbon nanotube fibers also show much more favorable impedance – the quality of the electrical connection — than state-of-the-art metal electrodes, making for better contact at lower voltages over long periods, Kemere said.
The working end of the fiber is the exposed tip, which is about the width of a neuron. The rest is encased with a three-micron layer of a flexible, biocompatible polymer with excellent insulating properties.
The challenge is in placing the tips. “That’s really just a matter of having a brain atlas, and during the experiment adjusting the electrodes very delicately and putting them into the right place,” said Kemere, whose lab studies ways to connect signal-processing systems and the brain’s memory and cognitive centers.
Doctors who implant deep brain stimulation devices start with a recording probe able to “listen” to neurons that emit characteristic signals depending on their functions, Kemere said. Once a surgeon finds the right spot, the probe is removed and the stimulating electrode gently inserted. Rice carbon nanotube fibers that send and receive signals would simplify implantation, Vitale said.
The fibers could lead to self-regulating therapeutic devices for Parkinson’s and other patients. Current devices include an implant that sends electrical signals to the brain to calm the tremors that afflict Parkinson’s patients.
“But our technology enables the ability to record while stimulating,” Vitale said. “Current electrodes can only stimulate tissue. They’re too big to detect any spiking activity, so basically the clinical devices send continuous pulses regardless of the response of the brain.”
Kemere foresees a closed-loop system that can read neuronal signals and adapt stimulation therapy in real time. He anticipates building a device with many electrodes that can be addressed individually to gain fine control over stimulation and monitoring from a small, implantable device.
“Interestingly, conductivity is not the most important electrical property of the nanotube fibers,” Pasquali said. “These fibers are intrinsically porous and extremely stable, which are both great advantages over metal electrodes for sensing electrochemical signals and maintaining performance over long periods of time.”
The paper is open access provided you register on the website.
Remote control for stimulation of the brain
Mo Costandi, neuroscientist and freelance science writer, has written a March 24, 2015 post for the Guardian science blog network focusing on neuronal remote control,
Two teams of scientists have developed new ways of stimulating neurons with nanoparticles, allowing them to activate brain cells remotely using light or magnetic fields. The new methods are quicker and far less invasive than other hi-tech methods available, so could be more suitable for potential new treatments for human diseases.
Researchers have various methods for manipulating brain cell activity, arguably the most powerful being optogenetics, which enables them to switch specific brain cells on or off with unprecedented precision, and simultaneously record their behaviour, using pulses of light.
This is very useful for probing neural circuits and behaviour, but involves first creating genetically engineered mice with light-sensitive neurons, and then inserting the optical fibres that deliver light into the brain, so there are major technical and ethical barriers to its use in humans.
Nanomedicine could get around this. Francisco Bezanilla of the University of Chicago and his colleagues knew that gold nanoparticles can absorb light and convert it into heat, and several years ago they discovered that infrared light can make neurons fire nervous impulses by heating up their cell membranes.
Polina Anikeeva’s team at the Massachusetts Institute of Technology adopted a slightly different approach, using spherical iron oxide particles that give off heat when exposed to an alternating magnetic field.
Although still in the experimental stages, research like this may eventually allow for wireless and minimally invasive deep brain stimulation of the human brain. Bezanilla’s group aim to apply their method to develop treatments for macular degeneration and other conditions that kill off light-sensitive cells in the retina. This would involve injecting nanoparticles into the eye so that they bind to other retinal cells, allowing natural light to excite them into firing impulses to the optic nerve.
Costandi’s article is intended for an audience that either understands the science or can deal with the uncertainty of not understanding absolutely everything. Provided you fall into either of those categories, the article is well written and it provides links and citations to the papers for both research teams being featured.
Taken together, the research at EPFL, Rice University, University of Chicago, and Massachusetts Institute of Technology provides a clue as to how much money and intellectual power is being directed at the brain.