Tag Archives: Indiana

Revising history with science and art

Caption: The 2000-year-old pipe sculpture’s bulging neck is evidence of thyroid disease as a result of iodine deficient water and soil in the ancient Ohio Valley. Credit: Kenneth Tankersley

An October 4, 2018 news item on ScienceDaily describes the analytic breakthrough,

Art often imitates life, but when University of Cincinnati anthropologist and geologist Kenneth Tankersley investigated a 2000-year-old carved statue on a tobacco pipe, he exposed a truth he says will rewrite art history.

Since its discovery in 1901, at the Adena Burial Mound in Ross County, Ohio, archaeologists have theorized that the the 8-inch pipe statue—carved into the likeness of an Ohio Valley Native American—represented an achondroplastic dwarf (AD). People with achondroplasia typically have short arms and legs, an enlarged head, and an average-sized trunk, the same condition as Emmy Award-winning actor Peter Dinklage from HBO’s “Game of Thrones.”

“During the early turn of the century, this theory was consistent with actual human remains of a Native American excavated in Kentucky, also interpreted by archaeologists as being an achondroplastic dwarf,” says Tankersley.

This theory flourished in the scientific literature until the turn of the 21st century when Tankersley looked closer.

“Here we have a carved statue and human remains, both of achondroplasia from the same time period,” says Tankersley. “But what caught my eye on this pipe statue was an obvious tumor on the neck that looked remarkably like a goiter [or goitre] or thyroid tumor.”

An October 2, 2018 University of Cincinnati (UC) news release (also on EurekAlert but published Oct. 3, 2018), reveals more details,

Tankersley collaborated with Frederic Bauduer, a visiting biological anthropologist and paleopathologist from the University of Bordeaux, UC’s sister university in France, to ultimately dispel previous academic literature claiming the sculpture as portraying achondroplasia.

“In archaeological science, flesh does not survive, so many ancient maladies go unnoticed and are almost always impossible to get at from an archaeological standpoint,” says Tankersley. “So what struck me was how remarkably Bauduer was using ancient art from various periods of antiquity to argue for the paleopathology he presented.”

Using radiocarbon dating on textile and bark samples surrounding the pipe at the site, the Adena pipe dates to approximately 2000 years ago, to the earliest evidence of tobacco.

Traditionally, tobacco is considered a sacred plant to Native Americans in this region, and smoking tobacco played an important role in their ceremonies, but he points to tobacco smoking as being long associated with an increased prevalence of goiter in low iodine intake zones worldwide.

From a medical perspective, Bauduer found the physical characteristics, such as the short forehead and long bones of the upper and lower limbs, simply not adding up as an achondroplastic dwarf.

“We found the tumor in the neck, as well as the figure’s squatted stance — not foreshortened legs as was formerly documented in the literature — were both signs and symptoms of thyroid disease,” says Tankersley.

“We already know that iodine deficiencies can lead to thyroid tumors, and the Ohio Valley area, where this artifact was found, has historically had iodine depleted soils and water relative to the advance of an Ice Age glacier about 300,000 years ago.”

Students in a university lab look through microscopes.

Tankersley (top center) teaches archaeology students to date soil, bones and textiles using radiocarbon science.

Profile of ancient tobacco pipe sculpture portraying a Native American wearing ceremonial regalia.

The figure’s bulging neck (goiter) and appearance of short stature are actually results of iodine deficient thyroid disease. The legs are bent in a tilted squat likely during a Native American ceremonial dance.

Tankersley says the Ohio Valley region, before the introduction of iodized salt in the 1920s,
was part of the so-called U.S. “goiter belt” where goiter frequency was relatively high —  five to 15 incidences per thousand.

The lower limbs on the statue, previously documented in the literature as short in stature, are actually normal size in bone length, according to Bauduer. Upon closer inspection, both Bauduer and Tankersley agree that the figure is also portrayed in a tilted squat, a common gait anomaly found in people with hypothyroidism.

The figure has what appears to be an abdominal six-pack, but both researchers say the detailed physical features indeed portray a normal physique except for the telltale signs of thyroid disease.

“The fact that the bones of the figure are all normal size leads us to believe the squat portrays more of an abnormal gait while likely in the stance of a typical Native American ritual dance,” says Tankersley, who is one-quarter Native American himself and regularly attends ceremonial events throughout Ohio and Kentucky.

“The regalia the figure is wearing is also strongly indicative of ancient Native Ohio Valley Shawnee, Delaware and Ojibwa to the north and Miami Nation tribes in Indiana.

“The traditional headdress, pierced ears with expanded spool earrings and loincloth with serpentine motif on the front and feathered bustle on back are also still worn by local Native tribes during ceremonial events today.”

Artistic clues

Portrait of Dr. Frederic Bauduer, biological pathologist from University of Bordeaux in France, on an ancient architectural balcony.

Frederic Bauduer, biological anthropologist, paleopathologist and critical collaborator on this research from the University of Bordeaux, UC’s sister university in France. photo/Frederic Bauduer

In addition to figures found in South America and Mesoamerica, Tankersley says the Adena pipe is the first known example of a goiter depicted in ancient Native North American art and one of the oldest from the Western Hemisphere.

“The other real take here is that a lot of people ask, ‘What is the value of ancient art?’” asserts Tankersley. “Well, here’s an example of ancient art that tells a deeper story. And similar indigenous art representations found in South America and Mesoamerica strengthen our hypothesis.”

Tankersley is interested in looking deeper for pathologies and maladies portrayed on other ancient artifacts from Native Americans thousands of years ago here in the Ohio Valley and elsewhere.

“Art history is beginning to help substantiate many scientific hypotheses,” says Tankersley. “Because artists are such keen students of anatomy, artisans such as this ancient Adena pipe sculptor could portray physical maladies with great accuracy, even before they were aware of what the particular disease was.”

Here’s a link to and a citation for the paper,

Medical Hypotheses Evidence of an ancient (2000 years ago) goiter attributed to iodine deficiency in North America by F. Bauduer, K. Barnett Tankersley. Medical Hypotheses Volume 118, September 2018, Pages 6-8 DOI: https://doi.org/10.1016/j.mehy.2018.06.011

This paper looks like it’s behind a paywall.

DARPA (US Defense Advanced Research Project Agency) ‘Atoms to Product’ program launched

It took over a year after announcing the ‘Atoms to Product’ program in 2014 for DARPA (US Defense Advanced Research Projects Agency) to select 10 proponents for three projects. Before moving onto the latest announcement, here’s a description of the ‘Atoms to Product’ program from its Aug. 27, 2014 announcement on Nanowerk,

Many common materials exhibit different and potentially useful characteristics when fabricated at extremely small scales—that is, at dimensions near the size of atoms, or a few ten-billionths of a meter. These “atomic scale” or “nanoscale” properties include quantized electrical characteristics, glueless adhesion, rapid temperature changes, and tunable light absorption and scattering that, if available in human-scale products and systems, could offer potentially revolutionary defense and commercial capabilities. Two as-yet insurmountable technical challenges, however, stand in the way: Lack of knowledge of how to retain nanoscale properties in materials at larger scales, and lack of assembly capabilities for items between nanoscale and 100 microns—slightly wider than a human hair.

DARPA has created the Atoms to Product (A2P) program to help overcome these challenges. The program seeks to develop enhanced technologies for assembling atomic-scale pieces. It also seeks to integrate these components into materials and systems from nanoscale up to product scale in ways that preserve and exploit distinctive nanoscale properties.

DARPA’s Atoms to Product (A2P) program seeks to develop enhanced technologies for assembling nanoscale items, and integrating these components into materials and systems from nanoscale up to product scale in ways that preserve and exploit distinctive nanoscale properties.

A Dec. 29, 2015 news item on Nanowerk features the latest about the project,

DARPA recently selected 10 performers to tackle this challenge: Zyvex Labs, Richardson, Texas; SRI, Menlo Park, California; Boston University, Boston, Massachusetts; University of Notre Dame, South Bend, Indiana; HRL Laboratories, Malibu, California; PARC, Palo Alto, California; Embody, Norfolk, Virginia; Voxtel, Beaverton, Oregon; Harvard University, Cambridge, Massachusetts; and Draper Laboratory, Cambridge, Massachusetts.

A Dec. 29, 2015 DARPA news release, which originated the news item, offers more information and an image illustrating the type of advances already made by one of the successful proponents,

DARPA recently launched its Atoms to Product (A2P) program, with the goal of developing technologies and processes to assemble nanometer-scale pieces—whose dimensions are near the size of atoms—into systems, components, or materials that are at least millimeter-scale in size. At the heart of that goal was a frustrating reality: Many common materials, when fabricated at nanometer-scale, exhibit unique and attractive “atomic-scale” behaviors including quantized current-voltage behavior, dramatically lower melting points and significantly higher specific heats—but they tend to lose these potentially beneficial traits when they are manufactured at larger “product-scale” dimensions, typically on the order of a few centimeters, for integration into devices and systems.

“The ability to assemble atomic-scale pieces into practical components and products is the key to unlocking the full potential of micromachines,” said John Main, DARPA program manager. “The DARPA Atoms to Product Program aims to bring the benefits of microelectronic-style miniaturization to systems and products that combine mechanical, electrical, and chemical processes.”

The program calls for closing the assembly gap in two steps: From atoms to microns and from microns to millimeters. Performers are tasked with addressing one or both of these steps and have been assigned to one of three working groups, each with a distinct focus area.

A2P

Image caption: Microscopic tools such as this nanoscale “atom writer” can be used to fabricate minuscule light-manipulating structures on surfaces. DARPA has selected 10 performers for its Atoms to Product (A2P) program whose goal is to develop technologies and processes to assemble nanometer-scale pieces—whose dimensions are near the size of atoms—into systems, components, or materials that are at least millimeter-scale in size. (Image credit: Boston University)

Here’s more about the projects and the performers (proponents) from the A2P performers page on the DARPA website,

Nanometer to Millimeter in a Single System – Embody, Draper and Voxtel

Current methods to treat ligament injuries in warfighters [also known as, soldiers]—which account for a significant portion of reported injuries—often fail to restore pre-injury performance, due to surgical complexities and an inadequate supply of donor tissue. Embody is developing reinforced collagen nanofibers that mimic natural ligaments and replicate the biological and biomechanical properties of native tissue. Embody aims to create a new standard of care and restore pre-injury performance for warfighters and sports injury patients at a 50% reduction compared to current costs.

Radio Frequency (RF) systems (e.g., cell phones, GPS) have performance limits due to alternating current loss. In lower frequency power systems this is addressed by braiding the wires, but this is not currently possibly in cell phones due to an inability to manufacture sufficiently small braided wires. Draper is developing submicron wires that can be braided using DNA self-assembly methods. If successful, portable RF systems will be more power efficient and able to send 10 times more information in a given channel.

For seamless control of structures, physics and surface chemistry—from the atomic-level to the meter-level—Voxtel Inc. and partner Oregon State University are developing an efficient, high-rate, fluid-based manufacturing process designed to imitate nature’s ability to manufacture complex multimaterial products across scales. Historically, challenges relating to the cost of atomic-level control, production speed, and printing capability have been effectively insurmountable. This team’s new process will combine synthesis and delivery of materials into a massively parallel inkjet operation that draws from nature to achieve a DNA-like mediated assembly. The goal is to assemble complex, 3-D multimaterial mixed organic and inorganic products quickly and cost-effectively—directly from atoms.

Optical Metamaterial Assembly – Boston University, University of Notre Dame, HRL and PARC.

Nanoscale devices have demonstrated nearly unlimited power and functionality, but there hasn’t been a general- purpose, high-volume, low-cost method for building them. Boston University is developing an atomic calligraphy technique that can spray paint atoms with nanometer precision to build tunable optical metamaterials for the photonic battlefield. If successful, this capability could enhance the survivability of a wide range of military platforms, providing advanced camouflage and other optical illusions in the visual range much as stealth technology has enabled in the radar range.

The University of Notre Dame is developing massively parallel nanomanufacturing strategies to overcome the requirement today that most optical metamaterials must be fabricated in “one-off” operations. The Notre Dame project aims to design and build optical metamaterials that can be reconfigured to rapidly provide on-demand, customized optical capabilities. The aim is to use holographic traps to produce optical “tiles” that can be assembled into a myriad of functional forms and further customized by single-atom electrochemistry. Integrating these materials on surfaces and within devices could provide both warfighters and platforms with transformational survivability.

HRL Laboratories is working on a fast, scalable and material-agnostic process for improving infrared (IR) reflectivity of materials. Current IR-reflective materials have limited use, because reflectivity is highly dependent on the specific angle at which light hits the material. HRL is developing a technique for allowing tailorable infrared reflectivity across a variety of materials. If successful, the process will enable manufacturable materials with up to 98% IR reflectivity at all incident angles.

PARC is working on building the first digital MicroAssembly Printer, where the “inks” are micrometer-size particles and the “image” outputs are centimeter-scale and larger assemblies. The goal is to print smart materials with the throughput and cost of laser printers, but with the precision and functionality of nanotechnology. If successful, the printer would enable the short-run production of large, engineered, customized microstructures, such as metamaterials with unique responses for secure communications, surveillance and electronic warfare.

Flexible, General Purpose Assembly – Zyvex, SRI, and Harvard.

Zyvex aims to create nano-functional micron-scale devices using customizable and scalable manufacturing that is top-down and atomically precise. These high-performance electronic, optical, and nano-mechanical components would be assembled by SRI micro-robots into fully-functional devices and sub-systems such as ultra-sensitive sensors for threat detection, quantum communication devices, and atomic clocks the size of a grain of sand.

SRI’s Levitated Microfactories will seek to combine the precision of MEMS [micro-electromechanical systems] flexures with the versatility and range of pick-and-place robots and the scalability of swarms [an idea Michael Crichton used in his 2002 novel Prey to induce horror] to assemble and electrically connect micron and millimeter components to build stronger materials, faster electronics, and better sensors.

Many high-impact, minimally invasive surgical techniques are currently performed only by elite surgeons due to the lack of tactile feedback at such small scales relative to what is experienced during conventional surgical procedures. Harvard is developing a new manufacturing paradigm for millimeter-scale surgical tools using low-cost 2D layer-by-layer processes and assembly by folding, resulting in arbitrarily complex meso-scale 3D devices. The goal is for these novel tools to restore the necessary tactile feedback and thereby nurture a new degree of dexterity to perform otherwise demanding micro- and minimally invasive surgeries, and thus expand the availability of life-saving procedures.

Sidebar

‘Sidebar’ is my way of indicating these comments have little to do with the matter at hand but could be interesting factoids for you.

First, Zyvex Labs was last mentioned here in a Sept. 10, 2014 posting titled: OCSiAL will not be acquiring Zyvex. Notice that this  announcement was made shortly after DARPA’s A2P program was announced and that OCSiAL is one of RUSNANO’s (a Russian funding agency focused on nanotechnology) portfolio companies (see my Oct. 23, 2015 posting for more).

HRL Laboratories, mentioned here in an April 19, 2012 posting mostly concerned with memristors (nanoscale devices that mimic neural or synaptic plasticity), has its roots in Howard Hughes’s research laboratories as noted in the posting. In 2012, HRL was involved in another DARPA project, SyNAPSE.

Finally and minimally, PARC also known as, Xerox PARC, was made famous by Steven Jobs and Steve Wozniak when they set up their own company (Apple) basing their products on innovations that PARC had rejected. There are other versions of the story and one by Malcolm Gladwell for the New Yorker May 16, 2011 issue which presents a more complicated and, at times, contradictory version of that particular ‘origins’ story.

Fundamental mechanical behaviour of cellulose nanocrystals (aka nanocrystalline cellulose)

Emil Venere at Purdue University offers an excellent explanation of why there’s so much international interest in cellulose nanocrystals (CNC aka, nanocrystalline cellulose [NCC]) in his Dec. 16, 2013 Purdue University (Indiana, US) news release (also on EurekAlert), Note: A link has been removed,

The same tiny cellulose crystals that give trees and plants their high strength, light weight and resilience, have now been shown to have the stiffness of steel.

The nanocrystals might be used to create a new class of biomaterials with wide-ranging applications, such as strengthening construction materials and automotive components.

Calculations using precise models based on the atomic structure of cellulose show the crystals have a stiffness of 206 gigapascals, which is comparable to steel, said Pablo D. Zavattieri, a Purdue University assistant professor of civil engineering.

Here’s an image of the cellulose crystals being examined,

This transmission electron microscope image shows cellulose nanocrystals, tiny structures that give trees and plants their high strength, light weight and resilience. The nanocrystals might be used to create a new class of biomaterials that would have a wide range of applications. (Purdue Life Sciences Microscopy Center)

This transmission electron microscope image shows cellulose nanocrystals, tiny structures that give trees and plants their high strength, light weight and resilience. The nanocrystals might be used to create a new class of biomaterials that would have a wide range of applications. (Purdue Life Sciences Microscopy Center)

You’ll notice this image is not enhanced and made pretty as compared to the images in my Dec. 16, 2013 posting about Bristol University’s Art of Science competition. It takes a lot of work to turn the types of images scientists use into ‘art’.

Getting back to the CNC, this news release was probably written by someone who’s not familiar with the other work being done in the field (university press officers typically write about a wide range of topics and cannot hope to have in depth knowledge on each topic) and so it’s being presented as if it is brand new information. In fact, there has been several years work done in five other national jurisdictions that I know of (Sweden, Finland, Canada, Brazil, and Israel) and there are likely more. That’s not including other US states pursuing research in this area, notably Wisconsin.

What I (taking into account  my limitations) find particularly exciting in this work is the detail they’ve been able to determine and the reference to quantum mechanics. Here’s more from the news release (Note: Links have been removed),

“It is very difficult to measure the properties of these crystals experimentally because they are really tiny,” Zavattieri said. “For the first time, we predicted their properties using quantum mechanics.”

The nanocrystals are about 3 nanometers wide by 500 nanometers long – or about 1/1,000th the width of a grain of sand – making them too small to study with light microscopes and difficult to measure with laboratory instruments.

The findings represent a milestone in understanding the fundamental mechanical behavior of the cellulose nanocrystals.

“It is also the first step towards a multiscale modeling approach to understand and predict the behavior of individual crystals, the interaction between them, and their interaction with other materials,” Zavattieri said. “This is important for the design of novel cellulose-based materials as other research groups are considering them for a huge variety of applications, ranging from electronics and medical devices to structural components for the automotive, civil and aerospace industries.”

From an applications perspective (which is what excites so much international interest),

The cellulose nanocrystals represent a potential green alternative to carbon nanotubes for reinforcing materials such as polymers and concrete. Applications for biomaterials made from the cellulose nanocrystals might include biodegradable plastic bags, textiles and wound dressings; flexible batteries made from electrically conductive paper; new drug-delivery technologies; transparent flexible displays for electronic devices; special filters for water purification; new types of sensors; and computer memory.

Cellulose could come from a variety of biological sources including trees, plants, algae, ocean-dwelling organisms called tunicates, and bacteria that create a protective web of cellulose.

“With this in mind, cellulose nanomaterials are inherently renewable, sustainable, biodegradable and carbon-neutral like the sources from which they were extracted,” Moon said. “They have the potential to be processed at industrial-scale quantities and at low cost compared to other materials.”

Biomaterials manufacturing could be a natural extension of the paper and biofuels industries, using technology that is already well-established for cellulose-based materials.

“Some of the byproducts of the paper industry now go to making biofuels, so we could just add another process to use the leftover cellulose to make a composite material,” Moon said. “The cellulose crystals are more difficult to break down into sugars to make liquid fuel. So let’s make a product out of it, building on the existing infrastructure of the pulp and paper industry.”

Their surface can be chemically modified to achieve different surface properties.

“For example, you might want to modify the surface so that it binds strongly with a reinforcing polymer to make a new type of tough composite material, or you might want to change the chemical characteristics so that it behaves differently with its environment,” Moon said.

Zavattieri plans to extend his research to study the properties of alpha-chitin, a material from the shells of organisms including lobsters, crabs, mollusks and insects. Alpha-chitin appears to have similar mechanical properties as cellulose.

“This material is also abundant, renewable and waste of the food industry,” he said.

Here’s a link to and a citation for the paper,

Anisotropy of the Elastic Properties of Crystalline Cellulose Iβ from First Principles Density Functional Theory with Van der Waals Interactions by Fernando L. Dri, Louis G. Hector Jr., Robert J. Moon, Pablo D. Zavattieri.  Cellulose December 2013, Volume 20, Issue 6, pp 2703-2718. 10.1007/s10570-013-0071-8

This paper is behind a paywall although you can preview the first few pages.

Chicanery and economics: physicists study art

It seems there’s a little tension between physicists and art historians, if this sternly worded passage from the article ‘Accelerated ion beams for art forensics‘ [open access] in the journal, Physics World, is to be believed,

The trial [a major art forgery scandal in Germany] clearly illustrates the folly—particularly in a society in which art can be a major investment—of relying entirely on art historians and others who claim that their expertise makes any scientific investigation pointless. [emphasis mine] Art experts play an important role in identifying the style, history, and context of a painting, but a solid scientific basis for the proper identification and classification of a piece of art must rely on information from other sources.

Co-authors of the article, Philippe Collon and Michael Wiescher, both at the University of Notre Dame (Indiana), as an associate professor of physics and a Frank M. Freimann Professor of Physics, respectively, describe how physicists and others use modern scientific equipment and means to uncover art fraud and to learn more about the past. From the article,

A host of approaches with origins in biology, chemistry, and physics have allowed scientists and art historians not only to look below a painting’s or artifact’s surface but also to analyze in detail the pigments used, investigate painting techniques and modifications done by the artist or by art restorers, find trace materials that reveal ages and provenances, and more. Those techniques can provide a slew of information to help substantiate or negate the authenticity of an artwork or artifact, and they also furnish information essential for careful restoration and preservation. In particular, nuclear physics has provided numerous analysis and detection techniques that involve accelerated ion beams from small to midsized accelerators such as electrostatic accelerators or cyclotrons. Key innovations include the capability to deliver well-focused particles and to identify trace elements to a very high degree of sensitivity.

The Jan. 20, 2012 news item on Nanowerk written by Marissa Gebhard provides more detail about specifics,

Laboratories in Europe, including several in Italy and one in the basement of the Louvre in Paris, have accelerators dedicated to the forensic analysis of art, and archaeological artifacts. These accelerator-based techniques have allowed not only to analyze the works themselves, but also to determine origin, trade and migration routes as well as dietary information. As an example, the analysis of the ruby eyes in a Babylonian statue of the goddess Ishtar using the Louvre’s accelerator showed that the rubies came from a mine in Vietnam, demonstrating that trade occurred between those far-apart regions some 4,000 years ago. [emphasis mine]

Both the news item and the article are fascinating. The Collon and Wiescher Jan. 2012 Physics World article examines in depth two techniques, proton-induced x-ray emission (PIXE) and Accelerator Mass Spectroscopy (AMS), used at Notre Dame University and elsewhere to examine artifacts. As I don’t feel competent to summarize the descriptions without advice from a subject matter expert, I suggest you read the article for more details.