Tag Archives: INIC

China, Iran, and nano

Iran and China have signed 17 MOUs (memoranda of agreement) to the tune of $600 billion over the next ten years according to a Jan. 23, 2016 article by Golnar Motevalli for Bloomberg Business,

China and Iran mapped out a wide-ranging 25-year plan to broaden relations and expand trade during the first visit by a Chinese leader to the Islamic republic in 14 years.

President Xi Jinping met with his counterpart Hassan Rouhani on Saturday [Jan. 23, 2016], a week after the lifting of international sanctions against Iran over its nuclear program. The Chinese leader is the first head of state of the six-country bloc that negotiated the historic deal to visit Iran.

“Today we discussed the strategic relationship between both countries, setting up a comprehensive 25-year plan and also promoting bilateral relations of up to $600 billion over the next 10 years,” Rouhani said.

The two countries signed 17 documents and letters of intent, IRNA reported, including treaties on judicial, commercial and civil matters. Long-term contracts in the energy and mining sectors were also discussed, Rouhani said. Iran is seeking to attract $50 billion annually in foreign investment for the country’s ailing $400 billion economy.

According to a Jan. 31, 2016 news item on Mehr Agency website, many science and technology agreements were included at the Jan. 23, 2016 meeting,

Iranian and Chinese officials inked several agreements to expand scientific and technological cooperation between the two countries, INIC [Iran Nanotechnology Initiative Council] reports.

Creation of Silk Road Science Fund, establishment of advanced technology parks in association with China, development of nanotechnology centers (INCC) and establishment of Iranian station to export therapeutic plants in China are among the most important MoUs signed in the field of science and technology.

The joint financial fund entitled Silk Road Science Fund facilitates mutual cooperation between the two parties by providing financial support through one of the following methods: Carrying out joint research, organization of joint workshops and exchanging researchers and university lecturers. …

… the INIC and Suzhou Technology Park agreed to develop activities of Iran Nano China Center (INCC), located in Suzhou Park in Nanopolis area. [emphasis mine]

For anyone interested in Nanopolis, I have two posts about the project (Jan. 20, 2014 and Sept. 26, 2014) but nothing more recent, until now.

This deal between China and Iran seems to have interested at least one observer who suggests that Russian interests might be threatened,from a Jan. 28, 2016 post by Olga Samofalova on the Russia Beyond the Headlines website (originally published by Vzglyad),

China has agreed to construct two nuclear power plants in Iran and import Iranian oil on a long-term basis. Such cooperation could threaten Russian positions, since Moscow had earlier announced that it would simultaneously be building eight nuclear plants in Iran. Russia’s place in the Chinese oil market, which for the last years has been squeezing out the Arabic countries, could also be affected.

Iranian-Chinese oil agreements will not have a direct impact on Russian-Chinese trade relations, according to Ivan Andriyevsky, the chairman of the board at the 2K engineering company. Firstly, the Russian oil that is supplied to the East is better in quality with respect to oil provided by the Persian Gulf countries. Secondly, the logistics supply lines of Russian and Iranian oil do not intersect, emphasizes Andriyevsky. This is why Iranian oil will primarily compete not with Russian oil, but with supplies from Saudi Arabia, Kuwait and other regional producers.

There’s some intriguing positioning noted in Samofalova’s piece.

As for what this might mean for the recently announced Russia-China high technology fund (the RUSNANO Zhongrong United Investment Fund featured in my Jan. 21, 2016 posting), I have no idea but this China-Iran deal does give me food for thought as the future unfolds. For example, Iran does a lot of ‘green chemistry’ research as per this Feb. 11, 2016 posting, April 22, 2014 posting, and Dec. 26, 2013 posting amongst others can attest and this is an area of research which China seems to be quite interested in supporting as this July 28, 2014 posting (scroll down about 75% of the way for the reference to China) about a washing detergent that cleans air pollution suggests. It makes one wonder about the Russian volte-face at the Paris Climate talks in December 2015 (my Dec. 14, 2015 posting).

Pomegranates, silver nanoparticles, and Persian carpets

One of the issues with adding silver nanoparticles to textiles is that they wash off and eventually enter our water supply. According to a Dec. 14. 2015 news item on Nanotechnology Now, Iranian scientists has devised a technique for affixing silver nanoparticles,

Iranian researchers produced laboratorial samples of antibacterial woolen fabrics by using nanoparticles which are able to preserve their properties even after five times of washing.

A Dec. 12, 2015 Iran Nanotechnology Initiative Council (INIC) press release, which originated the news item, provides more detail,

Nanoparticles used in the production of fabrics have been produced through a cost-effective method and by using environmentally-friendly materials.

The aim of the research was to obtain an eco-friendly method for the production and application of silver nanoparticles in carpet weaving industry to create antibacterial properties in the final product. The interesting point in this research is the application of pomegranate skin as the reducer in the process to produce nanoparticles.

Results showed that pigment extracted from pomegranate skin is able to be used in the production of silver nanoparticles. Therefore, this method decreases the application of chemical reducers in the synthesis of these nanoparticles, and it also decreases the environmental pollution. In addition, the synthesized nanoparticles preserve their antibacterial properties after being loaded on woolen fiber samples. Therefore, carpets woven by these fibers have antibacterial properties and no bacteria will grow on them.

After carrying out complementary tests and producing the fabrics and fibers at a large scale, the products can be used in carpet weaving industries and also in production of medical devices.

Based on the results, fabrics completed with silver nanoparticles synthesized at low ratio of pigment have antibacterial properties and they do not affect the color of samples. Fabric samples also conserve their antibacterial properties even after five times of washing. The decrease in pH value and increase in temperature improves exhaustion of silver nanoparticles on the wool.

Here’s a link to and a citation for the paper,

Novel method for synthesis of silver nanoparticles and their application on wool by Majid Nasiri Boroumand, Majid Montazer, Frank Simon, Jolanta Liesiene, Zoran Šaponjic, Victoria Dutschk. Applied Surface Science Volume 346, 15 August 2015, Pages 477–483 doi:10.1016/j.apsusc.2015.04.047

This paper is behind a paywall.

South American countries and others visit Iran’s Nanotechnology Initiative Council

The Iran Nanotechnology Initiative Council (INIC) news release states eight South American countries visited. By my count there were six South American countries (Argentina, Brazil, Ecuador, Bolivia, Venezuela, and Uruguay,), one North American country (Mexico), and one Caribbean country (Cuba). All eight can be described as Latin American countries.

An easy to understand error (I once forgot Mexico is part of North America and, for heaven sakes, I live in Canada and really should know better) as the designations can be confusing. That cleared up, here’s what the June 15, 2015 INIC news release had to say about the visit,

The ambassadors and charge d’affaires of 8 South American countries of Argentina, Brazil, Ecuador, Bolivia, Cuba, Venezuela, Uruguay and Mexico paid a visit to Iran Nanotechnology Initiative Council (INIC) to become familiar with its activities.

Among the objectives of the visit, which was requested by the abovementioned countries, mention can be made of introduction with INIC and its activities, presentation of nanotechnology achievements and products in the country by the INIC, creation and modification of international cooperation and creation of appropriate environment for exporting nanotechnology-based products to these countries.

In this visit, the programs, achievements and objectives of nanotechnology development in Iran were explained by the authorities of INIC. In addition and due to the needs of the countries whose representatives were present in the visit, a number of experts from the Iranian knowledge-based companies presented their nanotechnology products in the fields of packaging of agricultural products with long durability and water purification.

As usual with something from INIC, I long for more detail, e.g., when did the visit take place?

H/t to Nanotechnology Now June 15, 2015 news item.

Using stevia to synthesize gold nanoparticles?

The research into using stevia as a greener alternative to synthesize gold nanoparticles is from Iran (from a June 2, 2015 news item on Nanotechology Now),

Iranian researchers suggested the extract of stevia plant as a replacement for chemical solvents and reducers in the synthesis of gold nanoparticles.

A May 31, 2015 Iran Nanotechnology Initiative Council news release, which originated the news item, provides a little more detail,

Various chemical methods have been proposed for the synthesis of gold nanoparticles as the application of these particles has increased. These methods cause some problems, including environmental pollution and difficulty in synthesis. This research studied the possibility of using stevia leaf extract to reduce gold ions into atomic nanoparticles.

According to the researchers, the extract of stevia plant is biocompatible and it acts as a reducing and stabilizing agent. In addition, the simplicity of the method easily makes possible the quick biosynthesis of gold nanoparticles in different sizes.

Since the antibacterial effect of gold nanoparticles has been proved, these materials can be used in the production of detergents, packaging industry and production of medical drugs.

Gold nanoparticles stabilized with stevia extract in this research are absorbed by cells more than nanoparticles coated with chemical stabilizers (polymers). The reason is that nanoparticles stabilized with herbal extract contain various proteins and fibers on their surface. Therefore, the nanoparticles are more probable to diffuse into the cells through the multiple receivers of protein in comparison with the dual receiver of protein and chemical polymer. Therefore, it is expected that the transfer of protein and drugs into the cells can be adjusted by changing the size and shape of the nanoparticles.

Here’s a link to and a citation for the paper,

GC–MS analysis of bioactive components and synthesis of gold nanoparticle using Chloroxylon swietenia DC leaf extract and its larvicidal activity by Govindasamy Balasubramani, Rajendiran Ramkumar, Narayanaswamy Krishnaveni, Rajamani Sowmiya, Paramasivam Deepak, Dhayalan Arul, & Pachiappan Perumal. Journal of Photochemistry and Photobiology B: Biology Volume 148, July 2015, Pages 1–8  doi:10.1016/j.jphotobiol.2015.03.016

This paper is behind a paywall.

Detecting Ochratoxin A in agricultural products with gold nanoparticles

Iranian researchers have developed a fast, inexpensive way to test for a cancer-causing toxicant found in some agricultural products. From a Jan. 5, 2015 news item on Nanowerk (Note: A link has been removed),

Researchers from Isfahan University of Technology used gold nanoparticles in the production of a detection kit to find cancerous toxicant in agricultural products (“Ultrasensitive and quantitative gold nanoparticle-based immunochromatographic assay for detection of ochratoxin A in agro-products”).

The use of the kit increases speed, sensitivity and ease of application.

A Jan. 5, 2015 Iran Nanotechnology Initiative Council (INIC) news release, which originated the news item, describes Ochratoxin A and the kit,

Humans and animals are always threatened by various toxicants naturally produced in different food products. Ochratoxin A is a type of toxicant that is produced by some types of fungi, which has been classified in human cancerous materials (Group B2) by the International Agency for Research on Cancer (IARC).

There are many methods to detect this toxicant, but in addition to high costs, these methods are time-consuming and require skillful and expert people to carry out the tests. The fact is that in many places where the detection of ochratoxin A is a necessity, there is no equipment and the detection process fails.

Increasing the detection speed, ease of application, and reducing costs are among the advantages of the method proposed by the researchers. Obtaining technical knowledge for the production of various detection kits based on this method for different materials is another achievement of the researchers.

In this research, a fast and ultra-sensitive detection kit has been produced based on immunochromatography method. To this end, test tapes have been designed and produced by using gold nanoparticles markers, and the results are obtained by placing the sample on the tape after 15 minutes. Gold nanoparticles create red color after combining with the toxicant and the color is visible by naked eye too.

Here’s a link to and a citation for the published research,

Ultrasensitive and quantitative gold nanoparticle-based immunochromatographic assay for detection of ochratoxin A in agro-products by Marjan Majdinasab, Mahmoud Sheikh-Zeinoddin, Sabihe Soleimanian-Zad, Peiwu Li, Qi Zhang, Xin Li, and Xiaoqian Tang. Journal of Chromatography B Volume 974, 1 January 2015, Pages 147–154. doi:10.1016/j.jchromb.2014.10.034

This paper is behind a paywall.

Producing cellulose nanoparticles from waste cotton

This nanocellulose item comes courtesy of Iran, from a July 29, 2014 news item on Nanowerk (Note: A link has been removed),

Researchers from Amir Kabir University of Technology succeeded in the synthesis of cellulose nanoparticles by using two environmentally-friendly processes (“Spherical cellulose nanoparticles preparation from waste cotton using a green method”).

The use of waste cotton fibers for the production of cellulose nanoparticles is among the interesting points in this research.

In addition to biodegradability and the ability to be recovered and re-used, cellulose nanoparticles are light and cheap, and they have very desirable mechanical properties. Therefore, they have high potential to be used in pharmaceutics, foodstuff, cosmetics, paper production and composite manufacturing.

A July 29, 2014 Iran Nanotechnology Initiative Council (INIC) news release, which originated the news item, provides more detail about the research,

Dr. Tayyebeh Fattahi Mei-abadi, one of the researchers, explained about the advantages of this method over the usual methods, and said, “In this project, spherical cellulose nanoparticles were produced from waste cotton fibers through enzyme hydrolysis and ultrasound methods. Acidic hydrolysis is usually used in the majority of the researches on the production of cellulose nanoparticles. This method is not in agreement with environmental issues, and it leaves byproducts. But in this research, enzyme hydrolysis method was used, which enables the production of nanoparticles under mild condition without any environmental damage, and it does not require specific equipment. In addition, ultrasonic process was carried out with low energy in a short period, which makes cost-effective the production of cellulose nanoparticles through this method.”

In the production of the nanoparticles, various parts of cellulose enzyme were attached to cellulose chains, and they started to hydrolyze crystalline and amorphous areas. As hydrolysis goes on, particles with average size of 520 nm are formed. Then, ultrasound energy converts the hydrolyzed fibers into nanoparticles at about 70 nm in size.

Here’s a link to and a citation for the paper,

Spherical cellulose nanoparticles preparation from waste cotton using a green method by Tayebeh Fattahi Meyabadi, Fatemeh Dadashian, Gity Mir Mohamad Sadeghi, and Hamid Ebrahimi Zanjani Asl.Powder Technology Volume 261, July 2014, Pages 232–240 DOI: 10.1016/j.powtec.2014.04.039

This paper is behind a paywall.


Fewer silver nanoparticles washed off coated textiles

This time I have two complementary tidbits about silver nanoparticles, their use in textiles, and washing. The first is a June 30, 2014 news item on Nanowerk, with the latest research from Empa (Swiss Federal Laboratories for Materials Science and Technology) on silver nanoparticles being sloughed off textiles when washing them,

The antibacterial properties of silver-coated textiles are popular in the fields of sport and medicine. A team at Empa has now investigated how different silver coatings behave in the washing machine, and they have discovered something important: textiles with nano-coatings release fewer nanoparticles into the washing water than those with normal coatings …

A June 30,  2014 Empa news release, which originated the news item, describes the findings in more detail,

If it contains ‘nano’, it doesn’t primarily leak ‘nano’: at least that’s true for silver-coated textiles, explains Bernd Nowack of the «Technology and Society» division at Empa. During each wash cycle a certain amount of the silver coating is washed out of the textiles and ends up in the waste water. [emphasis mine] Empa analysed this water; it turned out that nano-coated textiles release hardly any nano-particles. That’s quite the opposite to ordinary coatings, where a lot of different silver particles were found. Moreover, nano-coated silver textiles generally lose less silver during washing. This is because considerably less silver is incorporated into textile fabrics with nano-coating, and so it is released in smaller quantities for the antibacterial effect than is the case with ordinary coatings. A surprising result that has a transformative effect on future analyses and on the treatment of silver textiles. «All silver textiles behave in a similar manner – regardless of whether they are nano-coated or conventionally-coated,» says Nowack. This is why nano-textiles should not be subjected to stricter regulation than textiles with conventional silver-coatings, and this is relevant for current discussions concerning possible special regulations for nano-silver.

But what is the significance of silver particles in waste water? Exposed silver reacts with the (small quantities of) sulphur in the air to form silver sulphide, and the same process takes place in the waste water treatment plant. The silver sulphide, which is insoluble, settles at the bottom of the sedimentation tank and is subsequently incinerated with the sewage sludge. So hardly any of the silver from the waste water remains in the environment. Silver is harmless because it is relatively non-toxic for humans. Even if silver particles are released from the textile fabric as a result of strong sweating, they are not absorbed by healthy skin.

I’ve highlighted Nowack’s name as he seems to have changed his opinions since I first wrote about his work with silver nanoparticles in textiles and washing in a Sept. 8, 2010 posting,

“We found that the total released varied considerably from less than 1 to 45 percent of the total nanosilver in the fabric and that most came out during the first wash,” Bernd Nowack, head of the Environmental Risk Assessment and Management Group at the Empa-Swiss Federal Laboratories for Materials Testing and Research, tells Nanowerk. “These results have important implications for the risk assessment of silver textiles and also for environmental fate studies of nanosilver, because they show that under certain conditions relevant to washing, primarily coarse silver-containing particles are released.”

How did the quantity of silver nanoparticles lost in water during washing change from “less than 1 to 45 percent of the total nanosilver in the fabric” in a 2010 study to “Empa analysed this water; it turned out that nano-coated textiles release hardly any nano-particles” in a 2014 study? It would be nice to find out if there was a change in the manufacturing process and whether or not this is global change or one undertaken in Switzerland alone.

Here’s a link to and a citation for the Empa paper,

Presence of Nanoparticles in Wash Water from Conventional Silver and Nano-silver Textiles by Denise M. Mitrano, Elisa Rimmele, Adrian Wichser, Rolf Erni, Murray Height, and Bernd Nowack. ACS Nano, Article ASAP DOI: 10.1021/nn502228w Publication Date (Web): June 18, 2014

Copyright © 2014 American Chemical Society

This paper is behind a paywall.

The second tidbit is from Iran and may help to answer my questions about the Empa research. According to a July 7, 2014 news item on Nanowerk (Note: A link has been removed),

Writing in The Journal of The Textile Institute (“Effect of silver nanoparticles morphologies on antimicrobial properties of cotton fabrics”), researchers from Islamic Azad University in Iran, describe the best arrangement for increasing the antibacterial properties of textile products by studying various structures of silver nanoparticles.

A July 7, 2014 news release from the Iran Nanotechnology Initiative Council (INIC), which originated the news item, provides more details,

By employing the structure presented by the researchers, the amount of nanoparticles stabilization on the fabric and the durability of its antibacterial properties increase after washing and some problems are solved, including the change in the fabric color.

Using the results of this research creates diversity in the application of various structures of nanoparticles in the complementary process of cotton products. Moreover, the color of the fabric does not change as the amount of consumed materials decreases, because the excess use of silver was the cause of this problem. On the other hand, the stability and durability of nanoparticles increase against standard washing. All these facts result in the reduction in production cost and increase the satisfaction of the customers.

The researchers have claimed that in comparison with other structures, hierarchical structure has much better antibacterial activity (more than 91%) even after five sets of standard washing.

This work on morphology would seem to answer my question about the big difference in Nowack’s description of the quantity of silver nanoparticles lost due to washing. I am assuming, of course, that something has changed with regard to the structure and/or shape of the silver nanoparticles coating the textiles used in the Empa research.

Getting back to the work in Iran, here’s a link to and a citation for the paper,

Effect of silver nanoparticles morphologies on antimicrobial properties of cotton fabrics by Mohammad Reza Nateghia & Hamed Hajimirzababa. The Journal of The Textile Institute Volume 105, Issue 8, 2014 pages 806-813 DOI: 10.1080/00405000.2013.855377 Published online: 21 Jan 2014

This paper is behind a paywall.

Overview of journal publications on topic of nanotechnology offers a surprise or two

The Iran National Nanotechnology Initiative (INIC) has released a report on the number of nanotechnology articles published in ISI (Institute for Scientific Information)-indexed journals, according to a May 28, 2014 news item on Nanowerk,

This report studies the number of nanotechnology articles published in ISI-indexed journals, and investigates the ascending or descending trend of the publication of such articles in ISI-indexed journals. The report then presents a list of conferences in which the highest number of nanotechnology articles have been presented.

A May 29, 2014 INIC news release offers some insight into the reasons for the report,

Scientific journals have always been among the most important tools in the development of science and technology, because by publishing scientific reports and articles, they demonstrate the movement of science borders. Like reliable references, the journals provide researchers with the latest scientific findings and help them achieve their research objects. The philosophy behind the publication of articles at the international level is to take out human discoveries from laboratories and scientific centers and to help the development of science by publishing them. Journals create an atmosphere to share scientific achievements and they prevent the loss or uselessness of the finding.

After less than two decades since the appearance of nanotechnology, this technology has penetrated all scientific aspects. Therefore, various journals in all sciences publish nanotechnology-related articles and reports. No comprehensive research has so far been carried out to determine the share of journals in the publication of nanotechnology articles. Introduction to nanotechnology penetration in the ISI-indexed journals is the main objective of the present study. Therefore, the following report studies the share of ISI-indexed journals in the publication of nanotechnology-related articles.

ISI Web of Knowledge includes 22,000 journals, 23 million patents, 192,000 articles presented in conferences, 5,500 websites and 5,000 volumes of books. Master Journal List includes the titles of all journals that are licensed by various products of Thomson Scientific Institute. The journals are annually evaluated, and according to the evaluation, approximately 8,000 to 9,000 of the journals acquire impact factor (IF) and are indexed in Journal Citation Report (JCR). JCR is in fact a databank of ISI-indexed journals. Only the articles that are published in the journals of this databank are indexed in Web of Science (WoS).

Here are some of the findings, from the news release,

Figure 1: Top 30 journals in publication of nanotechnology articles in 2001-2013  [downloaded from http://irannano.org/nano/index.php?ctrl=news&actn=news_view&id=46553&lang=2]

Figure 1: Top 30 journals in publication of nanotechnology articles in 2001-2013 [downloaded from http://irannano.org/nano/index.php?ctrl=news&actn=news_view&id=46553&lang=2]

Figure 1 demonstrates the top 30 journals that have published the highest number of nanotechnology articles in 2001-2013. APPLIED PHYSICS LETTERS and PHYSICAL REVIEW B have ranked first and second by publishing 24,382 and 23,717 articles, respectively. These two journals have published respectively 2.9% and 2.82% of all nanotechnology-related articles in the past 13 years. The two journals are the only ones that possess a share of nanotechnology articles publication higher than 2%, and other journals are far behind them. For instance, the JOURNAL OF APPLIED PHYSICS, which ranks third in the following chart, has published 1.95% of nanotechnology-related articles in the past 13 years.Among the top 30 journals, there are only four nanotechnology specific journals classified in Nanoscience and Nanotechnology category of ISI categories. The four journals are as follows: Nanotechnology, Journal of Nanoscience and Nanotechnology, Nano Letters and ACS Nano.

I find it surprising that Nature Nanotechnology is not on the list of the top 30 journals. I’m not arguing their results, it’s just that given a specific journal dedicated to nanotechnology topics, it’s unexpected.

You can find more in the May 29, 2014 INIC news release or here at:  http://statnano.com/searchstring.

Nanocellulose from sugarcane?

Iran adds to this blog’s growing catalogue of plant materials from which nanocellulose can be derived. From an April 27, 2014 news item on Nanowerk,

Researchers from University of Tehran utilized sugarcane waste to produce nanocomposite film (“All-cellulose nanocomposite film made from bagasse cellulose nanofibers for food packaging application”).

The product has unique physical and mechanical properties and has many applications in packaging, glue making, medicine and electronic industries.

An April 28, 2014 Iran Nanotechnology Initiative Council (INIC) news release, which originated the news item, describes the advantages of this potential product and the research that led to it,

These nanofibers have simpler, faster and more cost-effective production method in comparison with other production methods. The size of the produced cellulose nanofiber has been reported about 39±13 nm while tension resistant of the nanocomposite produced from the nanofibers has been reported about 140 MPa. The produced nanocomposite has higher strength in comparison with the majority of biodegradable and non-biodegradable films. It seems that the produced nanocomposite can be considered an appropriate option for the elimination of artificial polymers and oil derivatives from packaging materials.

In order to produce the product, cellulose fibers were produced through mechanical milling method after separation and purification of cellulose from sugarcane bagasse, and then nanopapers were produced. Next, full cellulose nanocomposite was produced through partial dissolving method, and its characteristics were evaluated.

Results showed that as the time of partial dissolving increases, the diffusivity of the nanocomposite into vapor decreases due to the increase in glassy part (amorphous) to crystalline part. However, thermal resistant decreases as the time of partial dissolving increases because a decrease is observed in the crystalline part.

In addition, when cellulose microfibers turn into nanofibers, resistance against the tension of the produced films increases. The researchers believe that the reason for the increase is the reduction in fault points (points that lead to the fracture in cellulose fibers), increase in specific area, and integrity of nanofibers. Transparency of samples significantly increases as the size of particles decreases to nanometric scale.

Here’s a link to and a citation for the paper,

All-cellulose nanocomposite film made from bagasse cellulose nanofibers for food packaging application by Moein Ghaderi, Mohammad Mousavi, Hossein Yousefi, & Mohsen Labbafi. Carbohydrate Polymers, vol. 104, issue 1, January 2014, pp. 59-65 http://dx.doi.org/10.1016/j.carbpol.2014.01.013

This paper is behind a paywall.

Iran’s work on turmeric (curcumin) as an anti-cancer drug

It’s been a while since I’ve mentioned either Iran or curcumin (a constituent of turmeric) but an April 15, 2014 news item on Nanowerk has given me an opportunity to do both,

Nanotechnology researchers from Tarbiat Modarres University [Iran] produced a new drug capable of detecting and removing cancer cells using turmeric …

The compound is made of curcumin found in the extract of turmeric, and has desirable physical and chemical stability and prevents the proliferation of cancer cells.

An April 16, 2014 Iran Nanotechnology Initiative Council (INIC) news release, which despite its date appears to have originated the news item, fills in details about the research,

In this drug, curcumin with high efficiency (approximately 87%) was loaded in the polymeric nanocarrier, and it created a spherical structure with the size of 140 nm. The drug has high physical and chemical stability. The drug was used successfully in laboratory conditions in the treatment of a type of aggressive tumor in the central nervous system, called glioblastoma (GBM).

The interesting point is that the fatal effect of nanocurcumin on mature stem cells derived from marrow and natural cells of skin fibroblast is observed at a concentration higher than a concentration that is effective on cancer cells. In other words, no fatal effect on natural cells is observed at concentrations that are fatal to cancer cells. It shows that curcumin prefers to enter cancer cells.

The size range of the nanocarrier used in this research is 15-100 nm. Physical and chemical stability, non-toxicity, and biodegradability are among the main characteristics of the nanocarriers. Based on the results, the nanocarrier used in this research has no toxic effect on cells. In other words, all the death in the cells is caused by curcumin, and dendrosome only results in bioavailability and transference of the drug into the cells.

“The drug has the potential to affect a number of message delivery paths in the cells, one of which is cell proliferation path. Therefore, the drug prefers to enter cancer cells rather than various types of natural cells,” the researchers said.

Here’s a link to and a citation for the paper,

Dendrosomal curcumin nanoformulation downregulates pluripotency genes via miR-145 activation in U87MG glioblastoma cells by Maryam Tahmasebi Mirgani, Benedetta Isacchi, Majid Sadeghizadeh, Fabio Marra, Anna Rita Bilia, Seyed Javad Mowla, Farhood Najafi, & Esmael Babaei. International Journal of Nanomedicine, vol. 9, issue 1, January 2014, pp. 403-417.DOI: http://dx.doi.org/10.2147/IJN.S48136

This is an open access paper.

I last wrote about turmeric or more specifically curcumin in a December 25, 2011 posting about research at UCLA (University of California at Los Angeles).