Tag Archives: Janelle Tam

2014 Sanofi BioGENEius Challenge Canada (SBCC) national winners announced

Last week on May 23, 2014, the Sanofi BioGENEius Challenge Canada (SBCC) National winners were announced in Ottawa. (A Feb. 20, 2013 posting recounts the organization’s history and accomplishments on its 20th anniversary). Here’s more about the 2014 national winners from a May 23, 2014 Sanofi BioGENEius Challenge Canada news release,

A novel method of HIV detection for newborns under the age of 18 months and for adults before three months post-transmission earned a grade 10, British Columbia student top national honours today [May 23, 2014] in the 2014 “Sanofi BioGENEius Challenge Canada” (SBCC).

Nicole Ticea, 15, from York House School in Burnaby, BC was awarded the top prize of $5,000 by a panel of eminent Canadian scientists assembled at the Ottawa headquarters of the National Research Council of Canada (NRC).

Her impressive research project, mentored at Simon Fraser University by associate professor, Dr. Mark Brockman, is the first test capable of analyzing HIV viral nucleic acids in a point-of-care, low-resource setting.Nicole’s research, was deemed an incredibly innovative solution to a global challenge according to the judges led by Dr. Julie Ducharme, General Manager, Human Health Therapeutics, NRC.

See a full project description below and online here: http://sanofibiogeneiuschallenge.ca/2014/05/23/

Ten brilliant young scientists from nine Canadian regions, all just 15 to 18 years old, took part in the national finals. They had placed first at earlier regional SBCC competitions, conducted between March 27 and May 22, 2014.

High school and CEGEP students from Victoria to Saskatoon to St. John’s, focused on biotechnology fields of discovery and study, submitted more than 200 proposals. Working closely with mentors, these students conducted research in diverse areas such as telomeres, diabetes, stress management, Alzheimer’s, autism and pulp production. Since its inauguration in 1994, more than 4,700 young Canadians have competed in SBCC, with the majority of competitors going on to pursue careers in science and biotechnology.

1st place winner, Nicole Ticea will compete for Canada on June 22-25 at the International BioGENEius Challenge, conducted at the annual BIO conference in San Diego, CA.

2nd place, $4,000 – Ontario: Varsha Jayasankar, 17, grade 12, Sir Winston Churchill Secondary School, St. Catherines won with research into how an extract created from mango ginger can be used to inhibit the growth of multiple antibiotic-resistant bacteria. Project description: http://sanofibiogeneiuschallenge.ca/2014/05/23/

3rd place, $3,000 – Ontario: Anoop Manjunath, 17, grade 11, University of Toronto Schools, Toronto investigated image processing techniques for the analysis of ultrasound stimulated bubble interactions with fibrin clots.Project description: http://sanofibiogeneiuschallenge.ca/2014/05/23/

There were a couple of other projects (one for its ‘nano’ focus and the other for its ‘wheat’ focus), which caught my attention, from the SBCC 2014 National Competitor Project Descriptions page by Anne Ramsay,

Amit Scheer, Grade 10

Colonel By Secondary School, Ottawa, ON

“Development of a Novel Quantum Dot-Aptamer Bioconjugate Targeted Cancer Therapy for Precision Nanomedicine Applications”

A novel nanoparticle for targeted cancer therapeutics is described. This research was effectuated to create a theranostic bioconjugate with an optimal effective therapeutic index, achieved by biomarker-specific targeting. Estimates show that over 14 million new cases of cancer are diagnosed annually worldwide. Aptamer-quantum dot (APT-QD) bioconjugates were synthesized by conjugating cadmium-telluride quantum dots (QDs, semiconductor nanoparticles) to aptamers (nucleic-acid based ligands), by amide crosslinking. Aptamers targeted mucin-1 (MUC1), a glycosylated surface protein overexpressed on many cancers, including MCF7 breast cancer cells, and only minimally expressed in MCF-10A non-cancerous cells. The bioconjugate and unmodified QD treatments (the control) were tested for cellular uptake and cytotoxicity in MCF7 (cancerous) and MCF-10A (comparison) cell cultures. MTT assays, which quantify cellular viability by assessing mitochondrial activity, were used for dose-response analysis at several treatment concentrations. APT-QDs caused a statistically significant decrease in viability specifically in MUC1-overexpressing cultures, suggesting cell-specific internalization by receptor-mediated endocytosis. Apoptosis and necrosis were quantified using immunofluorescence assays; bioconjugate-treated cells were early apoptotic after 4 hours, proving effective initiation of programmed cell death. Finally, confocal microscopy was used for aptamer-dependent nanoparticle internalization analysis, demonstrating that APT-QDs accumulate outside of nuclei. A fluorochrome-modified DNA complement to the aptamer was synthesized for co-localization of aptamers and QDs, proving effective endosomal escape for both components. The bioconjugate has applications in combination and theranostic treatments for cancer, and in precision medicine to diversify targeting based on patient-specific panomics analyses. The researcher created a novel bioconjugate nanoparticle and has proven numerous viable applications in cancer therapeutics.

Wenyu Ruan, Grade 9, & Amy Yu Ruiyun Wang, Grade 10

Walter Murray Collegiate Institute, Saskatoon, SK

“Identification of Leaf Rust Resistance in Wheat”

Leaf rust is the most common disease in wheat, a crop which contributes $11B annually to Canada’s economy. The most effective strategy to control leaf rust has been to grow resistant varieties. There are two general types of resistance genes found in wheat: Race-specific genes confer a high-level of resistance to specific strains of leaf rust but can be easily overcome by genetic mutation in pathogen populations, while slow rusting (APR) resistance provides partial resistance to a broad spectrum of races, but is typically effective only at the adult stage of plant growth. A three-phase experiment was conducted on a doubled-haploid population derived from the cross RL4452/AC Domain to determine if the resistance of a recently discovered gene (Lr2BS) worked with other resistance genes to synergistically enhance resistance to leaf rust. Linkage and quantitative trait loci (QTL) mapping were performed by combining our new genotypic data with a previously generated genetic map for this population, then adding rust disease data from our experiment to identify genomic regions associated with leaf rust resistance. In addition, a fluorescent microscope was used to examine host-pathogen interaction on a cellular level. These experiments showed that lines carrying Lr2BS alone, and in combination with other APR genes were susceptible at the seedling stage, which suggests that Lr2BS is an adult plant gene. It appears that the synergistic effect of some multiple gene combinations, including Lr2BS, enhances leaf rust resistance. Furthermore, QTL mapping identified an uncharacterized resistance gene (LrUsw4B) that conferred resistance at the seedling stage.

I am sorry to see they are not sending all three national finalists to the international competition as they did in 2012. As I noted in my July 16, 2012 posting the international standings did not reflect the national standings,

As the 2012 winner of the Sanofi BioGENEius Challenge Canada competition, Tam was invited to compete in this year’s international Sanofi BioGENEisu Challenge held in Boston, Massachusetts on June 19, 2012. [Janelle] Tam received an honourable mention for her work while Rui Song of Saskatoon placed third internationally.

Presumably the costs are too high to continue the practice.

Getting back to 2014, congratulations to all the competitors and the winners! And, good luck to Nicole Ticea at the International BioGENEius Challenge which will be conducted at the annual BIO conference, June 22-25  2014, in San Diego, CA!

Sanofi BioGENEius Challenge Canada awards national prizes to winners

I last wrote about Sanofi BioGENEius Challenge Canada and its awards in my Feb. 20, 2013 posting on the occasion of the organization’s 20th anniversary in Canada. Today, Apr. 9, 2013, there’s an annoucement that the 2013 Sanofi BioGENEius Challenge Canada prizes were awarded today in Ottawa,

Cutting edge research into an experimental therapy that deploys nano-particles of gold to kill cancer cells earned an Alberta high school student, 16, top national honours today in the 2013 “Sanofi BioGENEius Challenge Canada” (SBCC).

India-born Arjun Nair, 16, a Grade 11 student at Webber Academy, Calgary, was awarded the top prize of $5,000 by a panel of eminent Canadian scientists assembled at the Ottawa headquarters of the National Research Council of Canada (NRC).

His research project, mentored at the University of Calgary, advances an experimental cancer “photothermal therapy” which involves injecting a patient with gold nanoparticles.  The particles accumulate in tumours, forming so-called “nano-bullets” that can be heated to kill cancer cells.

Arjun showed how an antibiotic may overcome defences cancer deploys against the therapy and make the promising treatment more effective.  Arjun’s research, which a panel of expert judges led by Dr. Luis Barreto called “world class Masters or PhD-level quality,” also won a special $1,000 prize awarded to the project with the greatest commercial potential.

There were other winners too,

Eleven brilliant students from nine Canadian regions, all just 16 to 18 years old, took part in the national finals.  They had placed 1st at earlier regional SBCC competitions, conducted between March 21 and April 4.

Celebrating 20 years of inspiring young scientists in Canada, this year’s SBCC involved a total of 208 high school and CEGEP students collaborating on 123 projects, all mentored in professional labs over several months and submitted via the regional competitions.  Since its beginning in Toronto in 1994, some 4,500 young Canadians have competed in the SBCC, an event that has inspired sister BioGENEius competitions in the USA and Australia.

2nd place, $4,000 — British Columbia: Selin Jessa, 17, Grade 12, Dr. Charles Best Secondary School, Coquitlam, won the $4,000 2nd place prize with research into how genetic mutations naturally help some HIV patients escape symptoms.

Arjun and Selin will compete for Canada April 22-23 at the International BioGENEius Challenge, conducted at the annual BIO conference, this year in Chicago.

3rd place, $3,000 — Quebec: Eunice Linh You, 17, Grade 11, Laval Liberty High School, Laval, who investigated how to tailor stem cell treatments for Parkinson’s disease

4th place, $2,000 — Greater Toronto: Lauren Chan, 17, Grade 12, University of Toronto Schools, who described a potential new therapy to reduce the severity of diabetes

5th place, $1,000 — Manitoba: Daniel Huang, 16, Grade 11, St. John’s Ravenscourt School, Winnipeg, who discovered a potential new tactic to fight the world’s deadliest brain cancer

Honorable mention, $500:

Newfoundland, Jared Trask, 18, Kaitlyn Stockley, 17, Grade 12, Holy Spirit High School, Conception Bay West, who, for the second consecutive year, won the Atlantic region competition by proving novel ideas for creating biofuels;

Eastern Ontario, Adamo Young, 16, Grade 11, Lisgar Collegiate Institute, Ottawa, who found that altering its nitrogen supply appears to tame a toxic fungus that ruins billions worth of grain worldwide;

Southwestern Ontario, Melanie Grondin, 17, Shawn Liu, 18, Vincent Massey Secondary School, Windsor, who found a marker in medicine’s quest for the holy grail of leukaemia treatments: limitless supplies of healthy stem cells.

Saskatchewan, Saruul Uuganbayar, 17, Grade 12, Centennial Collegiate, Saskatoon, who invented a molecular therapy for mutated cells with the dream of curing cancer.

Given my interest in nanotechnology, Nair’s project is particularly intriguing,

Aiming to create an effective cancer-killing nano-bullet made of gold

Helping science develop a nano-bullet to defeat cancer is the futuristic vision of Arjun Nair, a 16-year-old Calgary high school student.

These “bullets” are formed by gold nanoparticles that, when injected into a patient, accumulate in cancerous tumours. Using light, the gold nanoparticles rapidly heat up in the tumours, killing only the cancer cells. Known as photothermal therapy (PTT), the idea has shown promise but isn’t that effective because cancer cells fight back, producing heat-shock proteins to protect themselves.

Arjun looked into the use of an antibiotic (17-AAG) to defeat cancer’s defence.

Nanoparticles are less than millionth of the size of grain of sand, making them pretty difficult to make and work with, says Arjun. He spent the last two years working on his idea, including the past year between Simon Trudel’s and David Cramb’s Nanoscience Labs at the University of Calgary [see my interview with Dr. Cramb in my Mar. 8, 2010 posting and he is mentioned here in other postings should you care to search his name].

It’s rare for a high-tech lab to allow a high school student to work with its expensive equipment but Dr. Cramb, Dr. Simon Trudel and Lab Manager, Amy Tekrony provided access and all important mentorship, he says.

“Proof-of-concepts were developed and tested in order to demonstrate the viability of PTT,” says Arjun.  “Moreover, after analyzing the literature a mathematical model was developed to evaluate a theoretical synergetic treatment.”

“I’ve entered science competitions since Grade 5. I really enjoy taking my ideas and making them happen in real life,” says Arjun, who also enjoys debating, sports and volunteer work.

He dreams of doing science in university, perhaps pursuing a career in medical research. One of the best parts of the competition was the great friendships Arjun has made. “I’m part of community of students who love sharing ideas and talking science.”

They make quite a big deal of these awards,

Following the presentation ceremony at the NRC, the students were received by Governor-General David Johnston at Rideau Hall, a distinguished educator prior to his vice-regal appointment.

Dr. Kellie Leitch, Parliamentary Secretary to the Minister of Human Resources Skills Development, keynote speaker at the awards ceremony, said: “It is so important that we have all of our skills and talent at work in Canada and the SBCC offers students a fantastic opportunity to experience science and technology in new ways, hopefully encouraging them toward exciting careers. I want to congratulate the winners, and all of the participants, of this year’s competition and I thank the organizers for all of the work that they have done in supporting young people in science.”

Sanofi Canada President and CEO Jon Fairest, who presented the top national prize, said: “The Sanofi Group is very proud to be founding sponsors of the Sanofi BioGENEIus Challenge Canada (SBCC) and participate in this milestone competition. With its 20-year heritage, the SBCC shows how critical partnerships are to advance science and talent in Canada. From the mentoring provided by dedicated academics, to the support of government and the private sector, the SBCC truly stands out as a model for collaboration. The SBCC and the incredible students who participate inspire us to all think differently about our future and ensure we have a strong foundation in place to create a sustainable healthcare system in Canada.”

The SBCC gives young scientists access to professional labs and academic mentors, encouraging the pursuit of future studies and careers in the country’s fast-growing biotechnology sector.

Each of the students worked for months conducting research and collaborating with university mentors.

It’s not just public officials and Sanofi officials who are paying attention,

The nine final national projects were presented at NRC headquarters Monday April 8 to a panel of eminent Canadian scientists:

  • Dr. Luis Barreto, MD, Chief Judge, Bioscience Education Canada
  • Dr. Roman Szumski, Vice President Research, National Research Council Canada
  • Dr. Paul Lasko, Scientific Director, Institute of Genetics, Canadian Institutes of Health Research
  • Dr. Robert Tsushima, Associate Dean of Research, Faculty of Science, York University
  • Dr. Pierre Meulien, President, Genome Canada
  • Dr. Ron Pearlman, Associate Scientific Director, Gairdner Foundation
  • Dr. Jerome Konecsni, President, Innovation Saskatchewan

On the panel as well: Ms. Janelle Tam, 18, of Waterloo, Ontario, SBCC’s national first-place winner in 2012.

National Awards Presenters, National Research Council Canada, April 9, 2013:

Commercialization Award – Dr. Ron Pearlman, Associate Scientific Director, Gairdner Foundation

5th Place – Dr. Alison Symington, VP, Corporate Development, Ontario Genomics Institute / Genome Canada

4th Place — Dr. Spriros Pagiatakis, Associate Dean, Research & Partnerships, York University

3rd Place – Dr. Alain Beaudet, President, Canadian Institutes of Health Research

2nd Place – John McDougall, President, National Research Council of Canada

1st Place – Jon Fairest, President and CEO, Sanofi Canada

The Canadian competition does not stand alone,

The Sanofi BioGENEius Challenge Canada (SBCC) is a national, biotechnology research competition that encourages high school and CEGEP students to pursue future studies and careers in the exciting field of biotechnology. The initiative is sponsored by Sanofi Pasteur Limited, Sanofi Canada, the National Research Council Canada/ Conseil national de recherches Canada (NRC-CNRC), Canadian Institutes of Health Research/Instituts de recherche en santé du Canada (CIHR-IRSC), York University, Genome Canada and the Government of Canada’s Youth Awareness Program. Canada’s respected Sanofi BioGENEius Challenge Canada has inspired counterpart competitions in the USA and Australia.

For more information, please see Wikipedia (http://bit.ly/11MtXX9), visit sanofibiogeneiuschallenge.ca, and follow us on Facebook or Twitter @BioscienceEdCan

About Sanofi

Sanofi, a global and diversified healthcare leader, discovers, develops and distributes therapeutic solutions focused on patients’ needs. Sanofi has core strengths in the field of healthcare with seven growth platforms: diabetes solutions, human vaccines, innovative drugs, rare diseases, consumer healthcare, emerging markets and animal health. Sanofi is listed in Paris (EURONEXT: SAN) and in New York (NYSE: SNY).

Sanofi Pasteur, the vaccines division of Sanofi, provides more than 1 billion doses of vaccine each year, making it possible to immunize more than 500 million people across the globe. A world leader in the vaccine industry, Sanofi Pasteur offers the broadest range of vaccines protecting against 20 infectious diseases. The company’s heritage, to create vaccines that protect life, dates back more than a century. Sanofi Pasteur is the largest company entirely dedicated to vaccines. Every day, the company invests more than EUR 1 million in research and development. For more information, please visit: www.sanofipasteur.com  or www.sanofipasteur.us

Good luck to Arjun Nair and Selin Jessa when they compete for Canada April 22-23, 2013 at the International BioGENEius Challenge, conducted at the annual BIO conference, in Chicago, Illinois.

Sanofi BioGENEius Challenge Canada celebrates 20 years

The first time (May 11, 2012 posting) I wrote about the Sanofi BioGENEius Challenge Canada (SBCC) competition was when Janelle Tam was recognized as the 2012 national winner for her work with nanocrystalline cellulose (NCC) or, as it is sometimes known, cellulose nanocrystals (CNC).  As I noted then,

For anyone who’s curious about Sanofi, it’s a French multinational pharmaceutical company headquartered in Paris, France. I found the Wikipedia essay a little more informative than the Sanofi company website .

Justifiably proud not only of Tam and other 2012 winners, SBCC has sent out a news release enumerating the many triumphs and benefits associated with this competition. From the SBCC Feb.20, 2012 news release,

Unexpected bonus prizes from a high school bioscience competition, mentored by some of Canada’s top research experts, range from six-figure scholarships, valuable networks and commercial patents to peer-reviewed journal citations, global publicity, international conference invitations and more, former teen participants say.

But the reward cited most often by alumni of the “Sanofi BioGENEius Challenge Canada” (SBCC), this year marking its 20th annual competition, is the eye-opening experience of watching their inventive ideas succeed and being encouraged in a professional lab, creating in many a career-shaping passion for science.

“That’s a benefit shared throughout Canada’s economy, which has a growing, $86 billion biotechnology sector, as well as with people worldwide,” says Jeff Graham, Chair of the Board at the Toronto-based Bioscience Education Canada, which manages the SBCC program.

“This program has been ‘infecting’ teens with what one mentor calls the ‘research virus’ and inspiring bioscience careers since 1994. And with hundreds of dedicated partner organizations and mentors nation-wide, we are extremely proud of the success achieved so far as we mark the 20th annual SBCC.

The competition’s latest surprise bonus prize winners are 2012 national competitors Jeanny Yao, 18, and Miranda Wang, 19 of Vancouver, both now in first year at universities in Toronto and Montreal respectively.  The pair will spend Feb. 27 in Long Beach California, invited by organizers of the prestigious TED 2013 conference to tell the world’s science elite how they identified a species of bacteria from the Fraser River’s muddy banks that helps decompose plastic.

Their BC regional SBCC-winning project came to public attention last May in a front page story by the Vancouver Sun (http://bit.ly/XrsaB9)  as the duo were packing to attend SBCC’s national finals in Ottawa.  In the white marble halls of National Research Council of Canada headquarters — the country’s science temple — SBCC’s high-level final judging panel recognised Jeanny and Miranda’s project with a special prize for the “greatest commercial potential.”  (The girls have since approached firms in BC and Ontario on commercialisation ideas.)

They were invited last summer to present their project again at TED@Vancouver (http://bit.ly/X5PRAF), part of a “worldwide talent search,” and were among a handful picked from 293 entrants to reprise their presentation in California.

TED is widely considered the world’s marquee annual science show-and-tell.  And sharing a stage with fellow speakers like U2’s lead singer Bono and PayPal Founder Peter Theil is a five exclamation mark adventure for a couple of university frosh.

“We are extremely excited about this opportunity…!! We couldn’t have done this without your help!!!” Miranda wrote, announcing the news to SBCC’s Vancouver coordinators, LifeSciences BC.  (For more on Jeanny and Miranda at TED: http://bit.ly/WRAs45).

According to the news release some 4500 Canadian teenagers have participated in the competition since 1994. There was a survey of 375 participants, from the news release,

In a survey of 375 past participants by Bioscience Education Canada [BEC], which runs SBCC, 84% said their participation helped determine their field of study or career plan; 74% were pursuing biotechnology-related education or professions, with 12.5% undecided.  Some 55% were current university students, 24% planned to apply after high school, and 21% were post-secondary graduates now in the workforce.  Nearly 60% of respondents were female and 79% had or have bursaries and/or scholarships.

Typical of comments teens relayed with the survey replies, from Brooke Drover of Vernon River, PEI: “It was amazing. So unbelievably stressful, but when my team came second place I could hardly breathe. It was the best feeling in the world knowing that I didn’t just play a sport and win a trophy. I helped the scientific community.”

“Thanks to hundreds of top scientist mentors who have shared their expertise and lab space with the student competitors, we’ve discovered and nurtured incredible talent in high schools and CEGEP classrooms nation-wide,” says Rick Levick, Executive Director of BEC and head of the national competition since its inception,

“The mentors are the unsung heroes of the SBCC program. They often bring out a passion for science and talent for research in kids who didn’t know they had any.”

While I do have some questions about the survey (when was it administered? how was it administered? why 375? etc.), I’m letting them go in appreciation of the participants’ extraordinary accomplishments, from the news release,

Ottawa

Maria Merziotis, $5,000 first place winner in the national 2008 SBCC, found her prize included an academic fast track.  At 21, when those her age at university typically complete an undergrad degree, she’s finishing second year at the University of Ottawa’s medical school, with papers about her flu-related research in preparation for academic publication.

And, just seven years after he first impressed SBCC’s august panel of national judges as a Grade 11 student, Ottawa’s James MacLeod, now 23, is completing a Queen’s University master’s degree in pathology and molecular medicine and applying for early acceptance into the department’s PhD program.

Both credit SBCC with helping them reach medical career doors unusually soon.  Says Maria: “The SBCC competition is the main reason I stand where I am today.  It allowed me to explore the field of research, and through the doors it opened, gained me early acceptance into medical school.”

Saskatchewan

Says Rui Song of Saskatoon, who in Grade 9, age 14 (a veteran of Saskatchewan’s unique SBCC program for kids in Grades 7 and 8) prevailed over much older teens to win the #1 national award in 2010: “Before the SBCC, I hadn’t even considered being a researcher. I now hope to continue my research journey in university and in my career to continue creating beneficial change in the world.”

Her 2010 work to genetically fingerprint a lentil crop-killing fungus left the expert national judges “astonished.”  She also placed 2nd in last year’s national competition, accepted an offer to spend last summer doing research at Harvard, and today, in Grade 12, is weighing full-time university offers.

Southwestern Ontario

The 2012 top national winner, Janelle Tam of Waterloo, says “SBCC was a huge part of why I started laboratory research at the university in high school, which was instrumental in my decision that I want to be a professor.”

Janelle, completing Grade 12 with studies at Princeton University ahead this fall, detailed the anti-ageing potential of a nano compound found in wood pulp, capturing media attention in at least 36 countries (http://bit.ly/XduBJd), including a social media blog by then-Ontario Premier Dalton McGuinty (http://bit.ly/THiq7P).  Last summer in Québec she detailed her findings to staff and researchers of CelluForce’s, Domtar Corp. and FPInnovations — Canadian firms leading the commercial development of nanocrystalline cellulose.

Newfoundland

At 17, Sarai Hamodat of St John’s, Newfoundland, entered a prize-winning SBCC project  showing that a traditional Asian oil remedy could ease the suffering of asthma patients, a project inspired by her hope of helping her asthmatic uncle.

Says Sarai, now 23 and a medical resident in pharmacology at the Queen Elizabeth II Health Sciences Centre in Halifax: “SBCC was my first real introduction to what the world of science has to offer.”

British Columbia

Taneille Johnson entered the competition in 2009 from Fort St. John (pop. 22,000) near the Alberta border in northern BC.  At 16, she lived alone for a summer to work with a University of Calgary mentor in a quest to decipher DNA mutations that may lie behind a rare disorder which causes early onset aging and progressive bone marrow failure.

Taneille, the first student from northern BC to enter the regional event, won it in 2010 and placed third overall at the national finals in Ottawa.  Now 20, she’s a second year BSc student of immunology at McGill University, Montreal, with a goal of medical school studies at the University of British Columbia.

“Not many first year university science students can approach their professor and show them the amount of lab experience I had from the SBCC,” she says, adding “I really cannot overstate how unique the SBCC experience is for high school students.”

Greater Toronto

A year after his first place national win in the 2011 SBCC, Toronto’s Marshall Zhang faced a tough decision: offers from three of the world’s most prestigious Ivy League universities — Yale, Harvard and Princeton.

“The SBCC changed the course of my life,” says Marshall, now a Harvard freshman, who at age 16, and mentored at the Hospital for Sick Kids, used a powerful supercomputer cluster to create a potential new treatment for cystic fibrosis.

On CBC’s “The Nature of Things,” host Dr. David Suzuki cited Marshall and his ideas as an example of the marvels of uninhibited teenage thinking.  CF patients and their parents from across Canada and elsewhere wrote or called out of the blue to congratulate and thank Marshall for his efforts on their behalf.  He was in Grade 11.

“I’d never met a CF patient before then,” he says, adding that the most memorable part of the entire adventure was realizing the real impact his research could have on people.

Manitoba

At 17, Ted Paranjothy of Winnipeg, inspired by a memory from five years old of a friend who died from leukemia, invested 3,000 research hours over two years after school with a mentor at the University of Manitoba, developing innovative ideas for cancer treatment.  Ted’s framework for an anti-cancer agent able to kill human cancer cells without harming healthy ones is an innovation on which he now holds a patent.

His Grade 12 project earned a triple crown of high school biotech science: a first place sweep of the 2007 SBCC regional and national competitions, as well as the Sanofi-sponsored International BioGENEius Challenge — the only Canadian to achieve that distinction so far.  The three first prize cheques totaled $15,000.

Later awarded some $150,000 in scholarships from other sources, Ted continued work with his distinguished mentor, Dr. Marek Los, and had three papers in peer-reviewed journals by the end of first year at UofM.  Now 22, Ted is an independent researcher in cell science at UofM.  He credits SBCC with enabling his university graduate-level research while still in high school, and says it “inspired me to pursue a career in biomedical research.”

Quebec

In 2011, a trio of Montreal CEGEP students entered the national SBCC with their new sorbet for vegetarians, having discovered a substitute for animal-based gelatine normally found in the frozen dessert.  They won 2nd prize overall, a special award for that year’s project with the greatest commercial potential, and a lot of public attention, which helped create connections with several patent lawyers.

Today, all three are at universities studying science.  “The SBCC definitely pushed to me to explore research opportunities in medicine,” says one team member, Simon Leclerc, adding that feedback from top scientists who evaluated their project and the experience gained was “inestimable… The SBCC is of great help for young, otherwise non-connected students to push their projects forward.”

Brava! Bravo!

Applications for the 2013 competition have been closed since November 2012 but there is a listing of the times and dates for the regional and national 2013 competitions. Although it’s unclear to me whether or not the public is invited to attend, you can get more details here.

2012 SANOFI BioGENEius Canada followup: Janelle Tam and CelluForce

Janelle Tam (high school student mentioned in my May 11, 2012 posting) was welcomed by CelluForce, the joint FPInnovation/Domtar company in Windsor, Québec, so she could demonstrate some of her nanocrystalline cellulose (NCC) research. Caroline Bouchard in a July 11, 2012 article for La Presse/La Tribune provides more information about the research and when any potential products might be created (Frrench language excerpt, I will attempt a translation),

Janelle Tam, une jeune Ontarienne de 17 ans, a découvert une substance bénéfique pour la santé à base de nanocellulose cristalline (NCC) telle que produite à l’usine Celluforce de Windsor.

Couplée chimiquement à des particules de carbone, la NCC, une substance extraite de la fibre du bois, serait un puissant agent antivieillissement et un antioxydant supérieur aux vitamines C et E.

Sans être considérée comme une véritable fontaine de jouvence, cette découverte s’avère prometteuse pour améliorer les produits de santé et anti-âge, des applications que Celluforce pourrait exploiter d’ici trois à cinq ans.

Translation here we go: Tam discovered a new substance, based on NCC, which is extracted from wood and produced by the CelluForce plant in Windsor, with anti-aging properties and  superior anti-oxidant properties to vitamins C & E. The NCC is combined with carbon nanoparticles (specifically buckminster fullerenes). CelluForce may be able to exploit this health/beauty application in the next three to five years.

The CelluForce folks were so excited about Tam & her work they presented her with a plaque when she visited their plant on July 9, 2012,

Janelle Tam and Dr. Richard Berry, Vice President, Chief Technology Officer at CelluForce (courtesy: CelluForce)

Tam’s research opens a new opportunity for NCC research which, in Canada, has mainly focussed on textiles, composites, and coatings. Here’s Tam describing her work (from the Bouchard article),

«Les antioxydants préviennent et traitent des maladies. Ils peuvent aussi être utilisés dans la conservation des aliments et dans les produits anti-âge. Certains antioxydants sont toutefois toxiques, ou encore, ne sont pas solubles dans l’eau. Par exemple, les vitamines C et E se dégradent, alors quand elles sont présentes dans un produit cosmétique, leur effet diminue avec le temps. La NCC est naturelle, non toxique, soluble et stable. Elle peut aussi réagir à la température ou au pH», explique Janelle Tam, originaire de Singapour et étudiante de 12e année au Waterloo Collegiate Institute.

Rough (very) translation: Antioxidants can prevent and treat illness. They can also be used for food preservation and anti-aging. Some antioxidants are toxic and/or insoluble in water. For example, vitamins C & E degrade so when they’re present in a cosmetic the effect tapers off over time. NCC is natural, nontoxic, soluble, and stable. It also reacts to temperature or pH levels,  explains Tam originally from Singapore and a student in grade 12 at Waterloo Collegiate Institute.

As the 2012 winner of the Sanofi BioGENEius Challenge Canada competition, Tam was invited to compete in this year’s international Sanofi BioGENEisu Challenge held in Boston, Massachusetts on June 19, 2012. Tam received an honourable mention for her work while Rui Song of Saskatoon placed third internationally. From the Sanofi BioGENEius Challenge Canada website,

A 16-year-old Saskatchewan girl with a goal of improving world health by engineering a more nutritious variety of lentil was among the top prize winners Tuesday June 19 at an international science competition for elite high school students.

Rui Song, a Grade 11 student at Saskatoon’s Walter Murray Collegiate, was awarded the $2,500 third place prize at this year’s International BioGENEius Challenge, conducted at the annual global BIO conference in Boston.

Janelle Tam, a Grade 12 student at Waterloo Collegiate Institute in Ontario, was awarded a $500 prize and honourable mention for her project — the invention of a disease-fighting, anti-aging compound using nano-particles from trees.

Both girls had earned berths in the international competition last month in the Sanofi BioGENEius Challenge Canada with first (Janelle) and second place (Rui) finishes.

Congratulations to both Rui Song and Janelle Tam.

I interviewed Dr. Richard Berry in my Aug. 27, 2010 posting where he very kindly answered my questions about cellulose, the nano kind and otherwise.

One final thought, why doesn’t CelluForce stimulate more innovative research on NCC by running a contest modeled on this Sanofi BioGENEius competition? They could call it something like the ‘CelluForce Creativity Crunch’.

Congratulations to Mildred Dresselhaus, winner of the 2012 Kavli Prize in Nanoscience

A pioneer in the field, Mildred Dresselhaus has been recognized for her work in nanoscience by the Kavli Foundation. From the May 31, 2012 news item on Nanowerk,

Mildred S. Dresselhaus is recognized with the Kavli Prize for Nanoscience for her seminal contributions to the science of carbon-based nanostructures and for her elucidation of the electron-phonon interaction on the nanoscale.

Dresselhaus has laid the foundation for our understanding of the influence of reduced dimensionality on the fundamental thermal and electrical properties of materials. Her early work on graphite intercalation compounds and carbon fibers presaged the discoveries of C60, the fullerenes, nanotubes, and graphene. She investigated the effects of phonon confinement and electron-phonon interactions in nanostructures, and provided the key insights that underlie today’s research into nanostructured thermoelectrics. She showed that in nanostructures it is possible to decouple thermal and electrical transport, with significant implications for energy use. Thanks to Dresselhaus’s work, we have an improved understanding of how energy flows and dissipates on the nanoscale.

The 2012 Kavli Nanoscience Citation webpage contextualizes her achievements,

The story of carbon is interwoven with the story of nanoscience. The 1996 Chemistry Nobel Prize for the discovery of fullerenes, the 2008 Kavli Nanoscience Prize for the discovery of nanotubes, and the 2010 Physics Nobel Prize for graphene all recognize the remarkable phenomena that occur in highly controlled carbon-based nanostructures. As early as the 1960’s, Dresselhaus led one of the very first groups that explored the carbon materials that form the basis for 2D graphene and 1D carbon nanotubes. These early experiments helped to map out the electronic band structure of these materials, critical to further understanding the unique properties they might possess. Dresselhaus studied intercalated two-dimensional graphene sheets and provided important insights into the properties of not only 2D graphene, but also of the rich interactions between graphene and the surrounding materials. Her early work on carbon fibers, beginning in the 1980’s, provided Dresselhaus with the understanding and perspective to postulate the existence and unusual attributes of one-dimensional ‘single wall carbon nanotubes (SWNTs)’, years in advance of their actual discovery. A key prediction included the possibility that SWNTs could behave like either metals or semiconductors, depending on their chirality. Dresselhaus and coworkers pointed out that nanotubes can be viewed as arising from the folding of a single sheet of carbon, like a piece of paper that is wrapped at different spiral angles. They showed that this very simple rearrangement of their structure completely controlled their properties. This prediction was subsequently shown to be true. Through her studies of the fundamental physics of carbon-based solids, Dresselhaus laid the foundation for knowledge that has been integral to today’s nanoscience of carbon.

Dresselhaus studied the transport and optical properties of nanostructured matter with an exquisite selection of experimental techniques providing unprecedented microscopic understanding. Regarding carbon nanostructures, she pioneered Raman spectroscopy as a sensitive tool for the characterization of materials one atomic layer in wall thickness, namely carbon nanotubes and graphene. Diameter selective resonance enhancement led to the observation of Raman spectra from one single nanotube. The high sensitivity of Raman spectroscopy to diameter and chirality made the technique the prime method for the characterization of carbon nanotubes. The success story has been seamlessly adapted to the characterization of graphene and is in use in hundreds of laboratories worldwide as a fundamental diagnostic tool for carbon-based nanostructures.

Materials are held together by electrons shared between atoms. When the energy of an electron in a solid is altered, the local bonding of the solid is perturbed, resulting in a change in the position of the atoms that make up the solid. In nanoscale materials, the spatial extent of electrons and phonons can be modulated, leading to dramatically different behaviors compared with extended solids. Dresselhaus has investigated this very fundamental electron–phonon interaction in nanostructures using the powerful techniques of Raman and Resonance Raman spectroscopy.

This science also laid a foundation for practical work today aimed at controlling how energy flows. Thermoelectric materials have the ability to convert heat energy to an electrical signal or, alternatively, to utilize electrical energy to actively cool a material. Nature provides materials in which the electrical and thermal conductivity are strongly linked, resulting in a seeming limit to the achievable efficiency of a thermoelectric. Dresselhaus demonstrated that in a one-dimensional structure, it is possible to separately adjust electrical and thermal conductivity, and that this should allow the creation of new generations of thermoelectric refrigerators and new ways of scavenging waste heat for useful purposes.

Dresselhaus recently co-published a paper about developing a new material, a bismuth-antimony film (mentioned in my April 27, 2012 posting). The Wikipedia essay on Mildred Dresselhaus notes that she was born November 11, 1930 and is currently a professor at MIT (Massachusetts Institute of Technology). Note the absence of the word, emerita*.

May 2012 has been an interesting month, I’ve had the opportunity to feature both a octogenerian* and a teenager (Janelle Tam [mentioned in my May 11, 2012 posting]) who prove you can contribute to your chosen field at almost any age.

*’Emeritus’ corrected to ’emerita’ and ‘nonogenerian’ corrected to ‘octogenerian’ on Feb. 22, 2017.

TAPPI 2012 nanotechnology conference in Canada

This coming Monday, June 4 to Thursday, June 7, 2012, the Nanotechnology for Renewable Materials conference (2012 TAPPI [Technical Association of the Pulp and Paper Industry] International Conference) will be taking place in Montréal, Québec.

As one might expect, there’s going to be a major emphasis on nanocrystalline cellulose (NCC) and Celluforce’s new NCC production plant in Windsor, Québec. Keynote speakers for the conference include (from the Keynote Speakers webpage),

Dr. Dylan J. Boday
Advisory Engineer Team Lead
IBM’s Materials Engineering Laboratory

Dr. Dylan J. Boday is the Advisory Engineer Team Lead for IBM’s Materials Engineering Laboratory. In this role, he leads efforts across multiple divisions to advance technological capabilities and enhance product performance.

Dylan’s research at IBM focuses on creating inventive pathways toward the development of polymers, composites, surface science, nanoparticles and hybrid materials. He has organized several strategic partnerships to leverage new materials development that align with specific business needs for IBM. He also established and now leads a global team focused on the sustainability of IBM’s products and is the co-lead of an upcoming international conference that will focus on the advances and challenges of sustainable materials.

As a member of the American Chemical Society Polymer Board, he provides leadership to the broader polymer science field. His technical contributions have led to more than 30 patent filings in the areas of electrostatic discharge and thermally conductive composites, functional nanomaterials and printed circuit board materials. He also has numerous published articles on composites, self healing materials and anti-corrosion coatings, in addition to serving as a reviewer for several scientific journals. In 2011, he was named an IBM Master Inventor and is a member of the IBM Smarter Planet invention review board.

Dylan holds a bachelor’s degree in Chemistry and a doctorate degree in Materials Engineering from the University of Arizona.

Jean Moreau
President and Chief Executive Officer
CelluForce

As President and CEO of CelluForce since February 2011, Jean Moreau brings a wealth of experience in finance, operations and business development which he acquired in both private and public corporations, in various fields including manufacturing, entertainment, distribution and consumer goods.

A chartered accountant for over 10 years at Arthur Andersen and Co., Mr. Moreau was responsible for the acquisition of numerous large companies and plants.

Among others, he headed financial and production planning teams as Vice President of Finance, Paper Production sector and Vice President of Supply for Domtar. As Chief Financial Officer, he was also involved in the introduction of the Supremex Income Fund on the Toronto Stock Exchange, raising $300M in capital funding and, in addition was responsible for the implementation of a strategic business plan at Guess Canada, which was subsequently named one of Canada’s 50 Best Managed Companies.

As head of the CelluForce team, Jean wished to promote, within several sectors of activity, the development of commercial applications related to NCC around the world, thus ensuring the company’s manufacturing and commercial growth.

Jean Hamel, Eng.
Vice President
FPInnovations

Jean Hamel, Eng., Vice President, FPInnovations, received his B.Sc. (1983), and M. Eng. (1985), in Mechanical Engineering from the University of Sherbrooke. He joined Pulp and Paper Research Institute of Canada (Paprican) as a Research Engineer to work on the technical development, optimization and troubleshooting of paper finishing equipment.

In 1995 he joined St-Laurent Paperboard as a Senior Process Engineer to work on product development, paper machine optimization and start-up of new finishing equipment. In 1996, he returned to Paprican where he led the construction of the pilot paper machine and developed the new Roll Testing Facility, the first business unit concept of the organization. In 2004 he became Manager of the Product Performance Program. Soon after merging of three research institutes (Paprican, Forintek, FERIC) to form FPInnovations in 2007, he was named the Director of Research for the Pulp & Paper Division of FPInnovations where he focused on accelerating the technology transfer and developing new innovation processes.

Since 2009 he has been the Vice President of FPInnovations, leading the innovation program on pulp and paper and shifting the R&D effort to develop new chemicals, biomaterials and composites from wood fibers. He currently sits on the boards of CelluForce, a Domtar-FPInnovations joint venture on nanocrystalline cellulose (NCC) production, Sustainable Chemistry Alliance (SCA), ICGQ, ADRIQ and NSERC Green Fiber Network.

Andy Atkinson
Manager, Emerging Sciences Policy
Policy, Planning and Coordination Division
Strategic Policy Branch
Health Canada

Andrew Atkinson is currently Manager of the Emerging Science Policy group under the Strategic Policy Branch of Health Canada.

Andrew is currently overseeing coordination of science policy issues across the various regulatory and research programs under the mandate of Health Canada. Prior to Health Canada, he was a manager under Environment Canada’s CEPA new chemicals program, where he oversaw chemical and nanomaterial risk assessments, as well as the development of risk assessment methodologies.

In parallel to domestic work, he has been actively engaged in ISO and OECD nanotechnology efforts, including co-chairing groups on nomenclature of nano-objects under ISO TC229.

It seems more heavily weighted towards Canadian keynote speakers with, as I hinted earlier,  a special nod to CelluForce. I did glance through the full conference programme and see that there is  healthy representation internationally (Hungary, China, Finland, US, Sweden, Japan, Alberta [sometimes that province does seem like a separate country],  etc.).

After hearing a murmur about developing standards for nanocellulose at the Feb. 2012 annual meeting of the American Association for Advancement of Science (AAAS), I was excited to find this on on p. 8 of the conference programme,

The success of the 2011 Workshop on International Standards for Nancellulose has resulted in writing of the Roadmap for the Development of International Standards for Nanocellulose (Draft 4). Since then TAPPI has formed the International Nanocellulose Standards Coordination Committee (INSCC) in its Nanotechnology Division to house and coordinate the execution of the Roadmap. The 2012 Workshop on International Standards for Nancellulose will bring workshop participants up-to-date on nanocellulose standards activities since the completion of the Roadmap (Draft 4), initiate coordination activities in several areas of nanocellulose standards development, and if necessary, discuss revisions to the Roadmap.

Perhaps one of these days they’ll have a final version of their Roadmap.

I last mentioned this annual conference in my Sept. 24, 2009 posting when it was held in Alberta and made passing references to the 2010 edition in Finland during an interview (my Aug. 27, 2010 posting) with Dr. Richard Berry of FPInnovations and to the 2011 edition in Washington, DC in my June 6, 2011 posting about the formation, by Domtar and FPInnovations, of CelluForce.

As for the 2012 edition, I wonder if they considered inviting Janelle Tam, the 16 year old student who won a national award for her work on a new application for NCC (my Disease-fighting and anti-aging with nanocrystalline cellulose (NCC) and Janelle Tam posting on May 11, 2012) to this conference. In any event, her national win entitled her to compete for an international award in Boston, Massachusetts June 18, 2012.

Disease-fighting and anti-aging with nanocrystalline cellulose (NCC) and Janelle Tam

Originally from Singapore, 16-year old Janelle Tam of Waterloo, Ontario has won first place nationally in the 2012 Sanofi BioGENEius Challenge Canada (SBCC) competition with her application for nanocrystalline cellulose. From the May 8, 2012 news item on physorg.com,

Janelle Tam, a Grade 12 student at Waterloo Collegiate Institute, was awarded the $5,000 first prize by an impressed panel of eminent Canadian scientists assembled at the Ottawa headquarters of the National Research Council of Canada.

The theme of the competition, “How will you change the world?” inspired hundreds of students to participate in 2012 SBCC events Canada-wide.

Canada’s next big technological and health breakthrough might come from cellulose, the woody material found in trees that enables them to stand. Cellulose is made up of tiny nano-particles called nano-crystalline cellulose (NCC) that are measured in thousandths of the width of a human hair.

Only recently discovered, Waterloo’s Janelle Tam is the first to show that NCC is a powerful antioxidant, and may be superior to Vitamin C or E because it is more stable and its effectiveness won’t diminish as quickly.

“NCC is non-toxic, stable, soluble in water and renewable, since it comes from trees,” says Janelle, a Grade 12 student at Waterloo Collegiate Institute.

“NCC is really a hot field of research in Canada,” says Janelle, who notes that antioxidants have anti-aging and health promotion properties, including wound healing since they neutralize “free radicals” that damage or kill cells.

Janelle chemically ‘paired’ NCC with a well-known nano-particle called a buckminster fullerene. These ‘buckyballs’ (carbon molecules that look like a soccer ball) are already used in cosmetic and anti-aging products she says. The new NCC-buckyball combination acted like a ‘nano-vacuum,’ sucking up free radicals and neutralizing them.

“The results were really exciting,” she says and especially since cellulose is already used as filler and stabilizer in many vitamin products. One day those products may be super-charged free radical neutralizers thanks to NCC, she hopes.

Jeff Hicks’ May 8, 2012 story for TheRecord.com about Tam and her NCC work offers some insight into the young scientist and the scientific process,

Janelle, 16, is admittedly stubborn.

Gets it from her dad Michael, a University of Waterloo chemical engineering professor.

… you’ve got to have gumption to spend three to four hours a day in a University of Waterloo lab from September to March to invent a disease-fighting, anti-aging compound.

A frustrating nano-globe almost kicked her into submission last December.

Three months into her work she realized she had messed up. Her experimental technique was flawed. Her results were as worthless as Leafs playoff tickets.

Janelle wanted to give up. She told her mom Dorothy, a literacy social worker, she was never returning to the lab. Her older sister and former Team Canada science partner Vivienne, could not be leaned on for advice. Vivienne, 19, had left for Princeton.

But Janelle’s dad settled her down.

“He’s one of the most perseverant people I know,” she said. “He tells me that research is about failing and failing and failing. And failures are all steps on the way to success.”

Tam will be in Boston, Massachusetts for June 18, 2012 to compete in Sanofi’s International BioGENEius Challenge, which takes place at the same time as Sanofi’s  BIO Annual International Convention. For anyone who’s curious about Sanofi, it’s a French multinational pharmaceutical company headquartered in Paris, France. I found the Wikipedia essay a little more informative than the Sanofi company website .

(For a mild change of pace) So, Sanofi is a large French company which sponsors this contest. Are Canadian companies sponsoring contests of this type? I ask the question because Canadian companies don’t invest in research and development at the same rate as companies in other countries and, it appears, do less to stimulate  interest and participation in science pursuits amongst youth. Developing an innovative society means having a much more comprehensive approach than publicity campaigns and retooling government funding programmes.

Getting back to Tam’s work, congratulations! This is very exciting stuff especially in light of some of the concerns expressed in Bertrand Marotte’s recent article on NCC for the Globe and Mail newspaper, mentioned in my May 8, 2012 posting.