Japanese scientists have developed a more precise method for culturing stem cells according to a March 14, 2017 news item on Nanowerk,
A team of researchers in Japan has developed a new platform for culturing human pluripotent stem cells that provides far more control of culture conditions than previous tools by using micro and nanotechnologies.
The Multiplexed Artificial Cellular Microenvironment (MACME) array places nanofibres, mimicking cellular matrices, into fluid-filled micro-chambers of precise sizes, which mimic extracellular environments.
Caption: The Multiplexed Artificial Cellular Microenvironment (MACME) array, consisted with a microfluidic structure and nanofibre array for mimicking cellular microenvironments. Credit: Kyoto University iCeMS
Human pluripotent stems cells (hPSCs) hold great promise for tissue engineering, regenerative medicine and cell-based therapies because they can become any type of cell. The environment surrounding the cells plays a major role in determining what tissues they become, if they replicate into more cells, or die. However, understanding these interactions has been difficult because researchers have lacked tools that work on the appropriate scale.
Often, stem cells are cultured in a cell culture medium in small petri dishes. While factors such as medium pH levels and nutrients can be controlled, the artificial set up is on the macroscopic scale and does not allow for precise control of the physical environment surrounding the cells.
The MACME array miniaturizes this set up, culturing stem cells in rows of micro-chambers of cell culture medium. It also takes it a step further by placing nanofibers in these chambers to mimic the structures found around cells.
Led by Ken-ichiro Kamei of Kyoto University’s Institute for Integrated Cell-Material Sciences (iCeMS), the team tested a variety of nanofiber materials and densities, micro-chamber heights and initial stem cell densities to determine the best combination that encourages human pluripotent stem cells to replicate.
They stained the cells with several fluorescent markers and used a microscope to see if the cells died, replicated or differentiated into tissues.
Their analysis revealed that gelatin nanofibers and medium-sized chambers that create medium seed cell density provided the best environment for the stem cells to continue to multiply. The quantity and density of neighboring cells strongly influences cell survival.
The array is an “optimal and powerful approach for understanding how environmental cues regulate cellular functions,” the researchers conclude in a recently published paper in the journal Small.
This array appears to be the first time multiple kinds of extracellular environments can be mounted onto a single device, making it much easier to compare how different environments influence cells.
The MACME array could substantially reduce experiment costs compared to conventional tools, in part because it is low volume and requires less cell culture medium. The array does not require any special equipment and is compatible with both commonly used laboratory pipettes and automated pipette systems for performing high-throughput screening.
Here’s a link to and a citation for the paper,
Microfluidic-Nanofiber Hybrid Array for Screening of Cellular Microenvironments by Ken-ichiro Kamei, Yasumasa Mashimo, Momoko Yoshioka, Yumie Tokunaga, Christopher Fockenberg, Shiho Terada, Yoshie Koyama, Minako Nakajima, Teiko Shibata-Seki, Li Liu, Toshihiro Akaike, Eiry Kobatake, Siew-Eng How, Motonari Uesugi, and Yong Chen. Small DOI: 10.1002/smll.201603104 Version of Record online: 8 MAR 2017
Should you have concerns about exposure to pesticides or chemical warfare agents (timely given events in Syria as per this April 4, 2017 news item on CBC [Canadian Broadcasting News Corporation] online) , scientists at the Lomonosov Moscow State University have developed a possible antidote according to a March 8,, 2017 news item on phys.org,
Members of the Faculty of Chemistry of the Lomonosov Moscow State University have developed novel nanosized agents that could be used as efficient protective and antidote modalities against the impact of neurotoxic organophosphorus compounds such as pesticides and chemical warfare agents. …
A group of scientists from the Faculty of Chemistry under the leadership of Prof. Alexander Kabanov has focused their research supported by a “megagrant” on the nanoparticle-based delivery to an organism of enzymes, capable of destroying toxic organophosphorous compounds. Development of first nanosized drugs has started more than 30 years ago and already in the 90-s first nanomedicines for cancer treatment entered the market. First such medicines were based on liposomes – spherical vesicles made of lipid bilayers. The new technology, developed by Kabanov and his colleagues, uses an enzyme, synthesized at the Lomonosov Moscow State University, encapsulated into a biodegradable polymer coat, based on an amino acid (glutamic acid).
Alexander Kabanov, Doctor of Chemistry, Professor at the Eshelman School of Pharmacy of the University of North Carolina (USA) and the Faculty of Chemistry, M. V. Lomonosov Moscow State University, one of the authors of the article explains: “At the end of the 80-s my team (at that time in Moscow) and independently Japanese colleagues led by Prof. Kazunori Kataoka from Tokyo began using polymer micelles for small molecules delivery. Soon the nanomedicine field has “exploded”. Currently hundreds of laboratories across the globe work in this area, applying a wide variety of approaches to creation of such nanosized agents. A medicine on the basis of polymeric micelles, developed by a Korean company Samyang Biopharm, was approved for human use in 2006.”
Professor Kabanov’s team after moving to the USA in 1994 focused on development of polymer micelles, which could include biopolymers due to electrostatic interactions. Initially chemists were interested in usage of micelles for RNA and DNA delivery but later on scientists started actively utilizing this approach for delivery of proteins and, namely, enzymes, to the brain and other organs.
Alexander Kabanov says: “At the time I worked at the University of Nebraska Medical Center, in Omaha (USA) and by 2010 we had a lot of results in this area. That’s why when my colleague from the Chemical Enzymology Department of the Lomonosov Moscow State University, Prof. Natalia Klyachko offered me to apply for a megagrant the research theme of the new laboratory was quite obvious. Specifically, to use our delivery approach, which we’ve called a “nanozyme”, for “improvement” of enzymes, developed by colleagues at the Lomonosov Moscow State University for its further medical application.”
Scientists together with the group of enzymologists from the Lomonosov Moscow State University under the leadership of Elena Efremenko, Doctor of Biological Sciences, have chosen organophosphorus hydrolase as a one of the delivered enzymes. Organophosphorus hydrolase is capable of degrading toxic pesticides and chemical warfare agents with very high rate. However, it has disadvantages: because of its bacterial origin, an immune response is observed as a result of its delivery to an organism of mammals. Moreover, organophosphorus hydrolase is quickly removed from the body. Chemists have solved this problem with the help of a “self-assembly” approach: as a result of inclusion of organophosphorus hydrolase enzyme in a nanozyme particles the immune response becomes weaker and, on the contrary, both the storage stability of the enzyme and its lifetime after delivery to an organism considerably increase. Rat experiments have proved that such nanozyme efficiently protects organisms against lethal doses of highly toxic pesticides and even chemical warfare agents, such as VX nerve gas.
Alexander Kabanov summarizes: “The simplicity of our approach is very important. You could get an organophosphorus hydrolase nanozyme by simple mixing of aqueous solutions of anenzyme and safe biocompatible polymer. This nanozyme is self-assembled due to electrostatic interaction between a protein (enzyme) and polymer”.
According to the scientist’s words the simplicity and technological effectiveness of the approach along with the obtained promising results of animal experiments bring hope that this modality could be successful and in clinical use.
Members of the Faculty of Chemistry of the Lomonosov Moscow State University, along with scientists from the 27th Central Research Institute of the Ministry of Defense of the Russian Federation, the Eshelman School of Pharmacy of the University of North Carolina at Chapel Hill (USA) and the University of Nebraska Medical Center (UNC) have taken part in the Project.
A new nanofiber-on-microfiber matrix could help produce more and better quality stem cells for disease treatment and regenerative therapies.
A matrix made of gelatin nanofibers on a synthetic polymer microfiber mesh may provide a better way to culture large quantities of healthy human stem cells.
Developed by a team of researchers led by Ken-ichiro Kamei of Kyoto University’s Institute for Integrated Cell-Material Sciences (iCeMS), the ‘fiber-on-fiber’ (FF) matrix improves on currently available stem cell culturing techniques.
Researchers have been developing 3D culturing systems to allow human pluripotent stem cells (hPSCs) to grow and interact with their surroundings in all three dimensions, as they would inside the human body, rather than in two dimensions, like they do in a petri dish.
Pluripotent stem cells have the ability to differentiate into any type of adult cell and have huge potential for tissue regeneration therapies, treating diseases, and for research purposes.
Most currently reported 3D culturing systems have limitations, and result in low quantities and quality of cultured cells.
Kamei and his colleagues fabricated gelatin nanofibers onto a microfiber sheet made of synthetic, biodegradable polyglycolic acid. Human embryonic stem cells were then seeded onto the matrix in a cell culture medium.
The FF matrix allowed easy exchange of growth factors and supplements from the culture medium to the cells. Also, the stem cells adhered well to the matrix, resulting in robust cell growth: after four days of culture, more than 95% of the cells grew and formed colonies.
The team also scaled up the process by designing a gas-permeable cell culture bag in which multiple cell-loaded, folded FF matrices were placed. The system was designed so that minimal changes were needed to the internal environment, reducing the amount of stress placed on the cells. This newly developed system yielded a larger number of cells compared to conventional 2D and 3D culture methods.
“Our method offers an efficient way to expand hPSCs of high quality within a shorter term,” write the researchers in their study published in the journal Biomaterials. Also, because the use of the FF matrix is not limited to a specific type of culture container, it allows for scaling up production without loss of cell functions. “Additionally, as nanofiber matrices are advantageous for culturing other adherent cells, including hPSC-derived differentiated cells, FF matrix might be applicable to the large-scale production of differentiated functional cells for various applications,” the researchers conclude.
Human stem cells that grew on the ‘fiber-on-fiber’ culturing system
It seems unexpected to stumble across presentations on robots and on artificial intelligence at an entertainment conference such as South by South West (SXSW). Here’s why I thought so, from the SXSW Wikipedia entry (Note: Links have been removed),
South by Southwest (abbreviated as SXSW) is an annual conglomerate of film, interactive media, and music festivals and conferences that take place in mid-March in Austin, Texas, United States. It began in 1987, and has continued to grow in both scope and size every year. In 2011, the conference lasted for 10 days with SXSW Interactive lasting for 5 days, Music for 6 days, and Film running concurrently for 9 days.
The 2017 SXSW Interactive featured separate presentations by Japanese roboticist, Hiroshi Ishiguro (mentioned here a few times), and EPFL (École Polytechnique Fédérale de Lausanne; Switzerland) artificial intelligence expert, Marcel Salathé.
Ishiguro’s work is the subject of Harry McCracken’s March 14, 2017 article for Fast Company (Note: Links have been removed),
I’m sitting in the Japan Factory pavilion at SXSW in Austin, Texas, talking to two other attendees about whether human beings are more valuable than robots. I say that I believe human life to be uniquely precious, whereupon one of the others rebuts me by stating that humans allow cars to exist even though they kill humans.
It’s a reasonable point. But my fellow conventioneer has a bias: It’s a robot itself, with an ivory-colored, mask-like face and visible innards. So is the third participant in the conversation, a much more human automaton modeled on a Japanese woman and wearing a black-and-white blouse and a blue scarf.
We’re chatting as part of a demo of technologies developed by the robotics lab of Hiroshi Ishiguro, based at Osaka University, and Japanese telecommunications company NTT. Ishiguro has gained fame in the field by creating increasingly humanlike robots—that is, androids—with the ultimate goal of eliminating the uncanny valley that exists between people and robotic people.
I also caught up with Ishiguro himself at the conference—his second SXSW—to talk about his work. He’s a champion of the notion that people will respond best to robots who simulate humanity, thereby creating “a feeling of presence,” as he describes it. That gives him and his researchers a challenge that encompasses everything from technology to psychology. “Our approach is quite interdisciplinary,” he says, which is what prompted him to bring his work to SXSW.
If you have the time, do read McCracken’t piece in its entirety.
You can find out more about the ‘uncanny valley’ in my March 10, 2011 posting about Ishiguro’s work if you scroll down about 70% of the way to find the ‘uncanny valley’ diagram and Masahiro Mori’s description of the concept he developed.
You can read more about Ishiguro and his colleague, Ryuichiro Higashinaka, on their SXSW biography page.
In the quest for reliable artificial intelligence, EPFL scientist Marcel Salathé argues that AI technology should be openly available. He will be discussing the topic at this year’s edition of South by South West on March 14th in Austin, Texas.
Will artificial intelligence (AI) change the nature of work? For EPFL theoretical biologist Marcel Salathé, the answer is invariably yes. To him, a more fundamental question that needs to be addressed is who owns that artificial intelligence?
“We have to hold AI accountable, and the only way to do this is to verify it for biases and make sure there is no deliberate misinformation,” says Salathé. “This is not possible if the AI is privatized.”
AI is both the algorithm and the data
So what exactly is AI? It is generally regarded as “intelligence exhibited by machines”. Today, it is highly task specific, specially designed to beat humans at strategic games like Chess and Go, or diagnose skin disease on par with doctors’ skills.
On a practical level, AI is implemented through what scientists call “machine learning”, which means using a computer to run specifically designed software that can be “trained”, i.e. process data with the help of algorithms and to correctly identify certain features from that data set. Like human cognition, AI learns by trial and error. Unlike humans, however, AI can process and recall large quantities of data, giving it a tremendous advantage over us.
Crucial to AI learning, therefore, is the underlying data. For Salathé, AI is defined by both the algorithm and the data, and as such, both should be publicly available.
Deep learning algorithms can be perturbed
Last year, Salathé created an algorithm to recognize plant diseases. With more than 50,000 photos of healthy and diseased plants in the database, the algorithm uses artificial intelligence to diagnose plant diseases with the help of your smartphone. As for human disease, a recent study by a Stanford Group on cancer showed that AI can be trained to recognize skin cancer slightly better than a group of doctors. The consequences are far-reaching: AI may one day diagnose our diseases instead of doctors. If so, will we really be able to trust its diagnosis?
These diagnostic tools use data sets of images to train and learn. But visual data sets can be perturbed that prevent deep learning algorithms from correctly classifying images. Deep neural networks are highly vulnerable to visual perturbations that are practically impossible to detect with the naked eye, yet causing the AI to misclassify images.
In future implementations of AI-assisted medical diagnostic tools, these perturbations pose a serious threat. More generally, the perturbations are real and may already be affecting the filtered information that reaches us every day. These vulnerabilities underscore the importance of certifying AI technology and monitoring its reliability.
A Feb.28,2017 news item on Nanowerk announces a proposed nerve regeneration technique (Note: A link has been removed),
A research team consisting of Mitsuhiro Ebara, MANA associate principal investigator, Mechanobiology Group, NIMS, and Hiroyuki Tanaka, assistant professor, Orthopaedic Surgery, Osaka University Graduate School of Medicine, developed a mesh which can be wrapped around injured peripheral nerves to facilitate their regeneration and restore their functions (Acta Biomaterialia, “Electrospun nanofiber sheets incorporating methylcobalamin promote nerve regeneration and functional recovery in a rat sciatic nerve crush injury model”).
This mesh incorporates vitamin B12—a substance vital to the normal functioning of nervous systems—which is very soft and degrades in the body. When the mesh was applied to injured sciatic nerves in rats, it promoted nerve regeneration and recovery of their motor and sensory functions.
Artificial nerve conduits have been developed in the past to treat peripheral nerve injuries, but they merely form a cross-link to the injury site and do not promote faster nerve regeneration. Moreover, their application is limited to relatively few patients suffering from a complete loss of nerve continuity. Vitamin B12 has been known to facilitate nerve regeneration, but oral administration of it has not proven to be very effective, and no devices capable of delivering vitamin B12 directly to affected sites had been available. Therefore, it had been hoped to develop such medical devices to actively promote nerve regeneration in the many patients who suffer from nerve injuries but have not lost nerve continuity.
The NIMS-Osaka University joint research team recently developed a special mesh that can be wrapped around an injured nerve which releases vitamin B12 (methylcobalamin) until the injury heals. By developing very fine mesh fibers (several hundred nanometers in diameter) and reducing the crystallinity of the fibers, the team successfully created a very soft mesh that can be wrapped around a nerve. This mesh is made of a biodegradable plastic which, when implanted in animals, is eventually eliminated from the body. In fact, experiments demonstrated that application of the mesh directly to injured sciatic nerves in rats resulted in regeneration of axons and recovery of motor and sensory functions within six weeks.
The team is currently negotiating with a pharmaceutical company and other organizations to jointly study clinical application of the mesh as a medical device to treat peripheral nerve disorders, such as CTS.
This study was supported by the JSPS KAKENHI program (Grant Number JP15K10405) and AMED’s Project for Japan Translational and Clinical Research Core Centers (also known as Translational Research Network Program).
Figure 1. Conceptual diagram showing a nanofiber mesh incorporating vitamin B12 and its application to treat a peripheral nerve injury.
8 February – 3 September 2017, Science Museum, London
Admission: £15 adults, £13 concessions (Free entry for under 7s; family tickets available)
Tickets available in the Museum or via sciencemuseum.org.uk/robots
Supported by the Heritage Lottery Fund
Throughout history, artists and scientists have sought to understand what it means to be human. The Science Museum’s new Robots exhibition, opening in February 2017, will explore this very human obsession to recreate ourselves, revealing the remarkable 500-year story of humanoid robots.
Featuring a unique collection of over 100 robots, from a 16th-century mechanical monk to robots from science fiction and modern-day research labs, this exhibition will enable visitors to discover the cultural, historical and technological context of humanoid robots. Visitors will be able to interact with some of the 12 working robots on display. Among many other highlights will be an articulated iron manikin from the 1500s, Cygan, a 2.4m tall 1950s robot with a glamorous past, and one of the first walking bipedal robots.
Robots have been at the heart of popular culture since the word ‘robot’ was first used in 1920, but their fascinating story dates back many centuries. Set in five different periods and places, this exhibition will explore how robots and society have been shaped by religious belief, the industrial revolution, 20th century popular culture and dreams about the future.
The quest to build ever more complex robots has transformed our understanding of the human body, and today robots are becoming increasingly human, learning from mistakes and expressing emotions. In the exhibition, visitors will go behind the scenes to glimpse recent developments from robotics research, exploring how roboticists are building robots that resemble us and interact in human-like ways. The exhibition will end by asking visitors to imagine what a shared future with robots might be like. Robots has been generously supported by the Heritage Lottery Fund, with a £100,000 grant from the Collecting Cultures programme.
Ian Blatchford, Director of the Science Museum Group said: ‘This exhibition explores the uniquely human obsession of recreating ourselves, not through paint or marble but in metal. Seeing robots through the eyes of those who built or gazed in awe at them reveals much about humanity’s hopes, fears and dreams.’
‘The latest in our series of ambitious, blockbuster exhibitions, Robots explores the wondrously rich culture, history and technology of humanoid robotics. Last year we moved gigantic spacecraft from Moscow to the Museum, but this year we will bring a robot back to life.’
Today [May ?, 2016] the Science Museum launched a Kickstarter campaign to rebuild Eric, the UK’s first robot. Originally built in 1928 by Captain Richards & A.H. Reffell, Eric was one of the world’s first robots. Built less than a decade after the word robot was first used, he travelled the globe with his makers and amazed crowds in the UK, US and Europe, before disappearing forever.
Getting back to the exhibition, the Guardian’s Ian Sample has written up a Feb. 7, 2017 preview (Note: Links have been removed),
Eric the robot wowed the crowds. He stood and bowed and answered questions as blue sparks shot from his metallic teeth. The British creation was such a hit he went on tour around the world. When he arrived in New York, in 1929, a theatre nightwatchman was so alarmed he pulled out a gun and shot at him.
The curators at London’s Science Museum hope for a less extreme reaction when they open Robots, their latest exhibition, on Wednesday [Feb. 8, 2016]. The collection of more than 100 objects is a treasure trove of delights: a miniature iron man with moving joints; a robotic swan that enthralled Mark Twain; a tiny metal woman with a wager cup who is propelled by a mechanism hidden up her skirt.
The pieces are striking and must have dazzled in their day. Ben Russell, the lead curator, points out that most people would not have seen a clock when they first clapped eyes on one exhibit, a 16th century automaton of a monk [emphasis mine], who trundled along, moved his lips, and beat his chest in contrition. It was surely mesmerising to the audiences of 1560. “Arthur C Clarke once said that any sufficiently advanced technology is indistinguishable from magic,” Russell says. “Well, this is where it all started.”
In every chapter of the 500-year story, robots have held a mirror to human society. Some of the earliest devices brought the Bible to life. One model of Christ on the cross rolls his head and oozes wooden blood from his side as four figures reach up. The mechanisation of faith must have drawn the congregations as much as any sermon.
But faith was not the only focus. Through clockwork animals and human figurines, model makers explored whether humans were simply conscious machines. They brought order to the universe with orreries and astrolabes. The machines became more lighthearted in the enlightened 18th century, when automatons of a flute player, a writer, and a defecating duck all made an appearance. A century later, the style was downright rowdy, with drunken aristocrats, preening dandies and the disturbing life of a sausage from farm to mouth all being recreated as automata.
That reference to an automaton of a monk reminded me of a July 22, 2009 posting where I excerpted a passage (from another blog) about a robot priest and a robot monk,
Since 1993 Robo-Priest has been on call 24-hours a day at Yokohama Central Cemetery. The bearded robot is programmed to perform funerary rites for several Buddhist sects, as well as for Protestants and Catholics. Meanwhile, Robo-Monk chants sutras, beats a religious drum and welcomes the faithful to Hotoku-ji, a Buddhist temple in Kakogawa city, Hyogo Prefecture. More recently, in 2005, a robot dressed in full samurai armour received blessings at a Shinto shrine on the Japanese island of Kyushu. Kiyomori, named after a famous 12th-century military general, prayed for the souls of all robots in the world before walking quietly out of Munakata Shrine.
Sample’s preview takes the reader up to our own age and contemporary robots. And, there is another Guardian article which offering a behind-the-scenes look at the then upcoming exhibition, a Jan. 28, 2016 piece by Jonathan Jones, ,
An android toddler lies on a pallet, its doll-like face staring at the ceiling. On a shelf rests a much more grisly creation that mixes imitation human bones and muscles, with wires instead of arteries and microchips in place of organs. It has no lower body, and a single Cyclopean eye. This store room is an eerie place, then it gets more creepy, as I glimpse behind the anatomical robot a hulking thing staring at me with glowing red eyes. Its plastic skin has been burned off to reveal a metal skeleton with pistons and plates of merciless strength. It is the Terminator, sent back in time by the machines who will rule the future to ensure humanity’s doom.
Backstage at the Science Museum, London, where these real experiments and a full-scale model from the Terminator films are gathered to be installed in the exhibition Robots, it occurs to me that our fascination with mechanical replacements for ourselves is so intense that science struggles to match it. We think of robots as artificial humans that can not only walk and talk but possess digital personalities, even a moral code. In short we accord them agency. Today, the real age of robots is coming, and yet even as these machines promise to transform work or make it obsolete, few possess anything like the charisma of the androids of our dreams and nightmares.
That’s why, although the robotic toddler sleeping in the store room is an impressive piece of tech, my heart leaps in another way at the sight of the Terminator. For this is a bad robot, a scary robot, a robot of remorseless malevolence. It has character, in other words. Its programmed persona (which in later films becomes much more helpful and supportive) is just one of those frightening, funny or touching personalities that science fiction has imagined for robots.
Can the real life – well, real simulated life – robots in the Science Museum’s new exhibition live up to these characters? The most impressively interactive robot in the show will be RoboThespian, who acts as compere for its final gallery displaying the latest advances in robotics. He stands at human height, with a white plastic face and metal arms and legs, and can answer questions about the value of pi and the nature of free will. “I’m a very clever robot,” RoboThespian claims, plausibly, if a little obnoxiously.
Except not quite as clever as all that. A human operator at a computer screen connected with Robothespian by wifi is looking through its video camera eyes and speaking with its digital voice. The result is huge fun – the droid moves in very lifelike ways as it speaks, and its interactions don’t need a live operator as they can be preprogrammed. But a freethinking, free-acting robot with a mind and personality of its own, Robothespian is not.
Our fascination with synthetic humans goes back to the human urge to recreate life itself – to reproduce the mystery of our origins. Artists have aspired to simulate human life since ancient times. The ancient Greek myth of Pygmalion, who made a statue so beautiful he fell in love with it and prayed for it to come to life, is a mythic version of Greek artists such as Pheidias and Praxiteles whose statues, with their superb imitation of muscles and movement, seem vividly alive. The sculptures of centaurs carved for the Parthenon in Athens still possess that uncanny lifelike power.
Most of the finest Greek statues were bronze, and mythology tells of metal robots that sound very much like statues come to life, including the bronze giant Talos, who was to become one of cinema’s greatest robotic monsters thanks to the special effects genius of Ray Harryhausen in Jason and the Argonauts.
Renaissance art took the quest to simulate life to new heights, with awed admirers of Michelangelo’s David claiming it even seemed to breathe (as it really does almost appear to when soft daylight casts mobile shadow on superbly sculpted ribs). So it is oddly inevitable that one of the first recorded inventors of robots was Leonardo da Vinci, consummate artist and pioneering engineer. Leonardo apparently made, or at least designed, a robot knight to amuse the court of Milan. It worked with pulleys and was capable of simple movements. Documents of this invention are frustratingly sparse, but there is a reliable eyewitness account of another of Leonardo’s automata. In 1515 he delighted Francois I, king of France, with a robot lion that walked forward towards the monarch, then released a bunch of lilies, the royal flower, from a panel that opened in its back.
One of the most uncanny androids in the Science Museum show is from Japan, a freakily lifelike female robot called Kodomoroid, the world’s first robot newscaster. With her modest downcast gaze and fine artificial complexion, she has the same fetishised femininity you might see in a Manga comic and appears to reflect a specific social construction of gender. Whether you read that as vulnerability or subservience, presumably the idea is to make us feel we are encountering a robot with real personhood. Here is a robot that combines engineering and art just as Da Vinci dreamed – it has the mechanical genius of his knight and the synthetic humanity of his perfect portrait.
The nano tech executive committee (chairman: Tomoji Kawai, Specially Appointed Professor, Osaka University) will be holding “nano tech 2017” – one of the world’s largest nanotechnology exhibitions, now in its 16th year – on February 15, 2017, at the Tokyo Big Sight convention center in Japan. 600 organizations (including over 40 first-time exhibitors) from 23 countries and regions are set to exhibit at the event in 1,000 booths, demonstrating revolutionary and cutting edge core technologies spanning such industries as automotive, aerospace, environment/energy, next-generation sensors, cutting-edge medicine, and more. Including attendees at the concurrently held exhibitions, the total number of visitors to the event is expected to exceed 50,000.
The theme of this year’s nano tech exhibition is “Open Nano Collaboration.” By bringing together organizations working in a wide variety of fields, the business matching event aims to promote joint development through cross-field collaboration.
Special Symposium: “Nanotechnology Contributing to the Super Smart Society”
Each year nano tech holds Special Symposium, in which industry specialists from top organizations from Japan and abroad speak about the issues surrounding the latest trends in nanotech. The themes of this year’s Symposium are Life Nanotechnology, Graphene, AI/IoT, Cellulose Nanofibers, and Materials Informatics.
Notable sessions include:
“Development of microRNA liquid biopsy for early detection of cancer”
Takahiro Ochiya, National Cancer Center Research Institute Division of Molecular and Cellular Medicine, Chief
AI / IoT
“AI Embedded in the Real World”
Hideki Asoh, AIST Deputy Director, Artificial Intelligence Research Center
Cellulose Nanofibers [emphasis mine]
“The Current Trends and Challenges for Industrialization of Nanocellulose”
Satoshi Hirata, Nanocellulose Forum Secretary-General
“Perspective of Materials Research”
Hideo Hosono, Tokyo Institute of Technology Professor
nano tech 2017, the 16th International Nanotechnology Exhibition & Conference
Date: February 15-17, 2017, 10:00-17:00
Venue: Tokyo Big Sight (East Halls 4-6 & Conference Tower)
Organizer: nano tech Executive Committee, JTB Communication Design
As you may have guessed the Alberta information can be found in the .Cellulose Nanofibers session. From the conference/seminar program page; scroll down about 25% of the way to find the Alberta presentation,
Production and Applications Development of Cellulose Nanocrystals (CNC) at InnoTech Alberta
Behzad (Benji) Ahvazi
InnoTech Alberta Team Lead, Cellulose Nanocrystals (CNC)
[ Abstract ]
The production and use of cellulose nanocrystals (CNC) is an emerging technology that has gained considerable interest from a range of industries that are working towards increased use of “green” biobased materials. The construction of one-of-a-kind CNC pilot plant [emphasis mine] at InnoTech Alberta and production of CNC samples represents a critical step for introducing the cellulosic based biomaterials to industrial markets and provides a platform for the development of novel high value and high volume applications. Major key components including feedstock, acid hydrolysis formulation, purification, and drying processes were optimized significantly to reduce the operation cost. Fully characterized CNC samples were provided to a large number of academic and research laboratories including various industries domestically and internationally for applications development.
[ Profile ]
Dr. Ahvazi completed his Bachelor of Science in Honours program at the Department of Chemistry and Biochemistry and graduated with distinction at Concordia University in Montréal, Québec. His Ph.D. program was completed in 1998 at McGill Pulp and Paper Research Centre in the area of macromolecules with solid background in Lignocellulosic, organic wood chemistry as well as pulping and paper technology. After completing his post-doctoral fellowship, he joined FPInnovations formally [formerly?] known as PAPRICAN as a research scientist (R&D) focusing on a number of confidential chemical pulping and bleaching projects. In 2006, he worked at Tembec as a senior research scientist and as a Leader in Alcohol and Lignin (R&D). In April 2009, he held a position as a Research Officer in both National Bioproducts (NBP1 & NBP2) and Industrial Biomaterials Flagship programs at National Research Council Canada (NRC). During his tenure, he had directed and performed innovative R&D activities within both programs on extraction, modification, and characterization of biomass as well as polymer synthesis and formulation for industrial applications. Currently, he is working at InnoTech Alberta as Team Lead for Biomass Conversion and Processing Technologies.
Canada scene update
InnoTech Alberta was until Nov. 1, 2016 known as Alberta Innovates – Technology Futures. Here’s more about InnoTech Alberta from the Alberta Innovates … home page,
Effective November 1, 2016, Alberta Innovates – Technology Futures is one of four corporations now consolidated into Alberta Innovates and a wholly owned subsidiary called InnoTech Alberta.
You will find all the existing programs, services and information offered by InnoTech Alberta on this website. To access the basic research funding and commercialization programs previously offered by Alberta Innovates – Technology Futures, explore here. For more information on Alberta Innovates, visit the new Alberta Innovates website.
As for InnoTech Alberta’s “one-of-a-kind CNC pilot plant,” I’d like to know more about it’s one-of-a-kind status since there are two other CNC production plants in Canada. (Is the status a consequence of regional chauvinism or a writer unfamiliar with the topic?). Getting back to the topic, the largest company (and I believe the first) with a CNC plant was CelluForce, which started as a joint venture between Domtar and FPInnovations and powered with some very heavy investment from the government of Canada. (See my July 16, 2010 posting about the construction of the plant in Quebec and my June 6, 2011 posting about the newly named CelluForce.) Interestingly, CelluForce will have a booth at nano tech 2017 (according to its Jan. 27, 2017 news release) although the company doesn’t seem to have any presentations on the schedule. The other Canadian company is Blue Goose Biorefineries in Saskatchewan. Here’s more about Blue Goose from the company website’s home page,
Blue Goose Biorefineries Inc. (Blue Goose) is pleased to introduce our R3TM process. R3TM technology incorporates green chemistry to fractionate renewable plant biomass into high value products.
Traditionally, separating lignocellulosic biomass required high temperatures, harsh chemicals, and complicated processes. R3TM breaks this costly compromise to yield high quality cellulose, lignin and hemicellulose products.
The robust and environmentally friendly R3TM technology has numerous applications. Our current product focus is cellulose nanocrystals (CNC). Cellulose nanocrystals are “Mother Nature’s Building Blocks” possessing unique properties. These unique properties encourage the design of innovative products from a safe, inherently renewable, sustainable, and carbon neutral resource.
Blue Goose assists companies and research groups in the development of applications for CNC, by offering CNC for sale without Intellectual Property restrictions. [emphasis mine]
Bravo to Blue Goose! Unfortunately, I was not able to determine if the company will be at nano tech 2017.
One final comment, there was some excitement about CNC a while back where I had more than one person contact me asking for information about how to buy CNC. I wasn’t able to be helpful because there was, apparently, an attempt by producers to control sales and limit CNC access to a select few for competitive advantage. Coincidentally or not, CelluForce developed a stockpile which has persisted for some years as I noted in my Aug. 17, 2016 posting (scroll down about 70% of the way) where the company announced amongst other events that it expected deplete its stockpile by mid-2017.
I have two nanotech business news bits, one from Turkey and one from Northern Ireland.
A Turkish company has sold one of its microscopes to the US National Aeronautics and Space Administration (NASA), according to a Jan. 20, 2017 news item on dailysabah.com,
Turkish nanotechnology company Nanomanyetik has begun selling a powerful microscope to the U.S. space agency NASA, the company’s general director told Anadolu Agency on Thursday [Jan. 19, 2017].
Dr. Ahmet Oral, who also teaches physics at Middle East Technical University, said Nanomanyetik developed a microscope that is able to map surfaces on the nanometric and atomic levels, or extremely small particles.
Nanomanyetik’s foreign customers are drawn to the microscope because of its higher quality yet cheaper price compared to its competitors.
“There are almost 30 firms doing this work,” according to Oral. “Ten of them are active and we are among these active firms. Our aim is to be in the top three,” he said, adding that Nanomanyetik jumps to the head of the line because of its after-sell service.
In addition to sales to NASA, the Ankara-based firm exports the microscope to Brazil, Chile, France, Iran, Israel, Italy, Japan, Poland, South Korea and Spain.
Electronics giant Samsung is also a customer.
“Where does Samsung use this product? There are pixels in the smartphones’ displays. These pixels are getting smaller each year. Now the smallest pixel is 15X10 microns,” he said. Human hair is between 10 and 100 microns in diameter.
“They are figuring inner sides of pixels so that these pixels can operate much better. These patterns are on the nanometer level. They are using these microscopes to see the results of their works,” Oral said.
Nanomanyetik’s microscopes produces good quality, high resolution images and can even display an object’s atoms and individual DNA fibers, according to Oral.
A Jan. 22, 2017 news article by Dominic Coyle for The Irish Times (Note: Links have been removed) shares this business news and mention of a world first,
MOF Technologies has raised £1.5 million (€1.73 million) from London-based venture capital group Excelsa Ventures and Queen’s University Belfast’s Qubis research commercialisation group.
MOF Technologies chief executive Paschal McCloskey welcomed the Excelsa investment.
Established in part by Qubis in 2012 in partnership with inventor Prof Stuart James, MOF Technologies began life in a lab at the School of Chemistry and Chemical Engineering at Queen’s.
Its metal organic framework (MOF) technology is seen as having significant potential in areas including gas storage, carbon capture, transport, drug delivery and heat transformation. Though still in its infancy, the market is forecast to grow to £2.2 billion by 2022, the company says.
MOF Technologies last year became the first company worldwide to successfully commercialise MOFs when it agreed a deal with US fruit and vegetable storage provider Decco Worldwide to commercialise MOFs for use in a food application.
TruPick, designed by Decco and using MOF Technologies’ environmentally friendly technology, enables nanomaterials control the effects of ethylene on fruit produce so it maintains freshness in storage or transport.
MOFs are crystalline, sponge-like materials composed of two components – metal ions and organic molecules known as linkers.
“We very quickly recognised the market potential of MOFs in terms of their unmatched ability for gas storage,” said Moritz Bolle from Excelsa Ventures. “This technology will revolutionise traditional applications and open countless new opportunities for industry. We are confident MOF Technologies is the company that will lead this seismic shift in materials science.
Before leaping to Panasonic’s latest makeup mirror news, here’s an earlier iteration of their product at the 2016 Consumer Electronics Show (CES),
That was posted on Jan. 10, 2016 by Makeup University.
Panasonic has come back in 2017 to hype its “Snow Beauty Mirror,” a product which builds on its predecessor’s abilities by allowing the mirror to create a makeup look which it then produces for the user. At least, they hope it will—in 2020. From a Jan. 8, 2017 article by Shusuke Murai about the mirror and Japan’s evolving appliances market for The Japan Times,
Panasonic Corp. is developing a “magic” mirror for 2020 that will use nanotechnology for high-definition TVs to offer advice on how to become more beautiful.
The aim of the Snow Beauty Mirror is “to let people become what they want to be,” said Panasonic’s Sachiko Kawaguchi, who is in charge of the product’s development.
“Since 2012 or 2013, many female high school students have taken advantage of blogs and other platforms to spread their own messages,” Kawaguchi said. “Now the trend is that, in this digital era, they change their faces (on a photo) as they like to make them appear as they want to be.”
When one sits in front of the computerized mirror, a camera and sensors start scanning the face to check the skin. It then shines a light to analyze reflection and absorption rates, find flaws like dark spots, wrinkles and large pores, and offer tips on how to improve appearances.
But this is when the real “magic” begins.
Tap print on the results screen and a special printer for the mirror churns out an ultrathin, 100-nanometer makeup-coated patch that is tailor-made for the person examined.
The patch is made of a safe material often used for surgery so it can be directly applied to the face. Once the patch settles, it is barely noticeable and resists falling off unless sprayed with water.
The technologies behind the patch involve Panasonic’s know-how in organic light-emitting diodes (OLED), Kawaguchi said. By using the company’s technology to spray OLED material precisely onto display substrates, the printer connected to the computerized mirror prints a makeup ink that is made of material similar to that used in foundation, she added.
Though the product is still in the early stages of development, Panasonic envisions the mirror allowing users to download their favorite makeups from a database and apply them. It also believes the makeup sheet can be used to cover blemishes and birthmarks.
Before coming up with the smart mirror, Panasonic conducted a survey involving more than 50 middle- to upper-class women from six major Asian cities whose ages ranged from their 20s to 40s about makeup habits and demands.
Some respondents said they were not sure how to care for their skin to make it look its best, while others said they were hesitant to visit makeup counters in department stores.
“As consumer needs are becoming increasingly diverse, the first thing to do is to offer a tailor-made solution to answer each individual’s needs,” Kawaguchi said.
Panasonic aims to introduce the smart mirror and cosmetics sheets at department stores and beauty salons by 2020.
But Kawaguchi said there are many technological and marketing hurdles that must first be overcome — including how to mass-produce the ultrathin sheets.
“We are still at about 30 percent of overall progress,” she said, adding that the company hopes to market the makeup sheet at a price as low as foundation and concealer combined.
“I hope that, by 2020, applying facial sheets will become a major way to do makeup,” she said.
For anyone interested in Japan’s appliances market, please read Murai’s article in its entirety.
Researchers at Tohoku University have, for the first time, successfully demonstrated the basic operation of spintronics-based artificial intelligence.
Artificial intelligence, which emulates the information processing function of the brain that can quickly execute complex and complicated tasks such as image recognition and weather prediction, has attracted growing attention and has already been partly put to practical use.
The currently-used artificial intelligence works on the conventional framework of semiconductor-based integrated circuit technology. However, this lacks the compactness and low-power feature of the human brain. To overcome this challenge, the implementation of a single solid-state device that plays the role of a synapse is highly promising.
The Tohoku University research group of Professor Hideo Ohno, Professor Shigeo Sato, Professor Yoshihiko Horio, Associate Professor Shunsuke Fukami and Assistant Professor Hisanao Akima developed an artificial neural network in which their recently-developed spintronic devices, comprising micro-scale magnetic material, are employed (Fig. 1). The used spintronic device is capable of memorizing arbitral values between 0 and 1 in an analogue manner unlike the conventional magnetic devices, and thus perform the learning function, which is served by synapses in the brain.
Using the developed network (Fig. 2), the researchers examined an associative memory operation, which is not readily executed by conventional computers. Through the multiple trials, they confirmed that the spintronic devices have a learning ability with which the developed artificial neural network can successfully associate memorized patterns (Fig. 3) from their input noisy versions just like the human brain can.
The proof-of-concept demonstration in this research is expected to open new horizons in artificial intelligence technology – one which is of a compact size, and which simultaneously achieves fast-processing capabilities and ultralow-power consumption. These features should enable the artificial intelligence to be used in a broad range of societal applications such as image/voice recognition, wearable terminals, sensor networks and nursing-care robots.
Here are Fig. 1 and Fig. 2, as mentioned in the press release,
Fig. 1. (a) Optical photograph of a fabricated spintronic device that serves as artificial synapse in the present demonstration. Measurement circuit for the resistance switching is also shown. (b) Measured relation between the resistance of the device and applied current, showing analogue-like resistance variation. (c) Photograph of spintronic device array mounted on a ceramic package, which is used for the developed artificial neural network. Courtesy: Tohoku University
Fig. 2. Block diagram of developed artificial neural network, consisting of PC, FPGA, and array of spintronics (spin-orbit torque; SOT) devices. Courtesy: Tohoku University
For anyone interested in my other posts on memristors, artificial brains, and artificial intelligence, you can search this blog for those terms and/or Neuromorphic Engineering in the Categories section.