Posts Tagged ‘McGill University’

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Montréal Neuro and one of Europe’s biggest research enterprises, the Human Brain Project

Tuesday, January 29th, 2013

Its official title is the Montréal Neurological Institute and Hospital (Montréal Neuro) which is and has been, for several decades, an international centre for cutting edge neurological research. From the Jan. 28, 2013 news release on EurekAlert,

The Neuro

The Montreal Neurological Institute and Hospital — The Neuro, is a unique academic medical centre dedicated to neuroscience. Founded in 1934 by the renowned Dr. Wilder Penfield, The Neuro is recognized internationally for integrating research, compassionate patient care and advanced training, all key to advances in science and medicine. The Neuro is a research and teaching institute of McGill University and forms the basis for the Neuroscience Mission of the McGill University Health Centre.

Neuro researchers are world leaders in cellular and molecular neuroscience, brain imaging, cognitive neuroscience and the study and treatment of epilepsy, multiple sclerosis and neuromuscular disorders. For more information, visit theneuro.com.

Nonetheless, it was a little surprising to see that ‘The Neuro’ is part one of the biggest research projects in history since it’s the European Union, which is bankrolling the project (see my posting about the Jan. 28, 2013 announcement of the winning FET Flagship Initatives). Here’s more information about the project, its lead researchers, and Canada’s role, from the news release,

The goal of the Human Brain Project is to pull together all our existing knowledge about the human brain and to reconstruct the brain, piece by piece, in supercomputer-based models and simulations. The models offer the prospect of a new understanding of the human brain and its diseases and of completely new computing and robotic technologies. On January 28 [2013], the European Commission supported this vision, announcing that it has selected the HBP as one of two projects to be funded through the new FET [Future and Emerging Technologies] Flagship Program.

Federating more than 80 European and international research institutions, the Human Brain Project is planned to last ten years (2013-2023). The cost is estimated at 1.19 billion euros. The project will also associate some important North American and Japanese partners. It will be coordinated at the Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland, by neuroscientist Henry Markram with co-directors Karlheinz Meier of Heidelberg University, Germany, and Richard Frackowiak of Centre Hospitalier Universitaire Vaudois (CHUV) and the University of Lausanne (UNIL).

Canada’s role in this international project is through Dr. Alan Evans of the Montreal Neurological Institute (MNI) at McGill University. His group has developed a high-performance computational platform for neuroscience (CBRAIN) and multi-site databasing technologies that will be used to assemble brain imaging data across the HBP. He is also collaborating with European scientists on the creation of ultra high-resolution 3D brain maps. «This ambitious project will integrate data across all scales, from molecules to whole-brain organization. It will have profound implications for our understanding of brain development in children and normal brain function, as well as for combatting brain disorders such as Alzheimer’s Disease,» said Dr. Evans. “The MNI’s pioneering work on brain imaging technology has led to significant advances in our understanding of the brain and neurological disorders,” says Dr. Guy Rouleau, Director of the MNI. “I am proud that our expertise is a key contributor to this international program focused on improving quality of life worldwide.”

“The Canadian Institutes of Health Research (CIHR) is delighted to acknowledge the outstanding contributions of Dr. Evans and his team. Their work on the CBRAIN infrastructure and this leading-edge HBP will allow the integration of Canadian neuroscientists into an eventual global brain project,” said Dr. Anthony Phillips, Scientific Director for the CIHR Institute of Neurosciences, Mental Health and Addiction. “Congratulations to the Canadian and European researchers who will be working collaboratively towards the same goal which is to provide insights into neuroscience that will ultimately improve people’s health.”

“From mapping the sensory and motor cortices of the brain to pioneering work on the mechanisms of memory, McGill University has long been synonymous with world-class neuroscience research,” says Dr. Rose Goldstein, Vice-Principal (Research and International Relations). “The research of Dr. Evans and his team marks an exciting new chapter in our collective pursuit to unlock the potential of the human brain and the entire nervous system – a critical step that would not be possible without the generous support of the European Commission and the FET Flagship Program.”

Canada is not the only non-European Union country making an announcement about its role in this extraordinary project. There’s a Jan. 28, 2013 news release on EurekAlert touting Israel’s role,

The European Commission has chosen the Human Brain Project, in which the Hebrew University of Jerusalem is participating, as one of two Future and Emerging Technologies Flagship topics. The enterprise will receive funding of 1.19 billion euros over the next decade.

The project will bring together top scientists from around the world who will work on one of the great challenges of modern science: understanding the human brain. Participating from Israel will a team of eight scientists, led by Prof. Idan Segev of the Edmond and Lily Safra Center for Brain Sciences (ELSC) at the Hebrew University, Prof. Yadin Dudai of the Weizmann Institute of Science, and Dr. Mira Marcus-Kalish of Tel Aviv University.

…

More than 80 universities and research institutions in Europe and the world will be involved in the ten-year Human Brain Project, which will commence later this year and operate until the year 2023. The project will be centered at the Ecole Polytechnique Federale de Lausanne (EPFL) in Switzerland, headed by Prof. Henry Markram, a former Israeli who was recruited ten years ago to the EPFL.

The participation of the Israeli scientists testifies to the leading role that Israeli brain research occupies in the world, said Israeli President Shimon Peres. “Israel has put brain research at the heart of its efforts for the coming decade, and our country is already spearheading the global effort towards the betterment of our understanding of mankind. I am confident that the forthcoming discoveries will benefit a wide range of domains, from health to industry, as well as our society as a whole,” Peres said.

“The human brain is the most complex and amazing structure in the universe, yet we are very far from understanding it. In a way, we are strangers to ourselves. Unraveling the mysteries of the brain will help us understand our functioning, our choices, and ultimately ourselves. I congratulate the European Commission for its vision in selecting the Human Brain Project as a Flagship Mission for the forthcoming decade,” said Peres.

What’s amusing is that as various officials and interested parties (such as myself) wax lyrical about these projects, most of the rest of the world is serenely oblivious to it all.

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Situating Science in Canada; excerpts from the Winter 2013 newsletter

Thursday, January 24th, 2013

Situating Science is a SSHRC (Social Science and Humanities Research Council) funded network for Canadian Science and Technology Studies (STS) and Philosophy and History of Science scholars amongst others who examine the social impacts of science both in the present and in the past. The network is in its seventh and final year of funding (sunsetting) although there are plans for the future as per its most recent newsletter. Here’s a brief description of Situating Science’s  recent activities along with a listing of activities taking place in various Canadian cities over the next several months, as well as, a hint about future plans, from the Winter 2013 newsletter,

Happy New Year!

It’s been a busy few months. Members of the Cluster are now able to present you with all the latest in this Winter 2013 newsletter. In this issue, the Social Sciences and Humanities Research Council of Canada’s Strategic Knowledge Cluster, Situating Science: Cluster for the Humanist and Social Study of Science (www.situsci.ca) is pleased to update you on activities …

…

Given our past successes, Cluster members plan to move forward with a few grant applications to sustain and initiate partnerships and activities. Some partners and stakeholders met in October to begin the planning process for a national and international partnership to explore sciences, technologies and their publics. They also plan to arrange to meet again this year to concretize plans for a sustainable network and national centre.

The Cluster hopes to build upon partnership activities with scholars and institutions in Southeast Asia and India. Members are currently planning to seek support for a Canada-Southeast Asia and India partnership to explore cosmopolitanism and circulation of knowledge.

The Cluster Centre and its many and varied local partners kept Dr. Evelyn Fox Keller busy during her 3.5 week fall visit to Halifax as the Cluster Visiting Scholar. Her time here allowed her to research genotypic plasticity, biological information and mathematical biology on top of participating in several activities, including a public lecture on “Paradigm Shifts and Revolutions in Contemporary Biology”. She then continued to Montreal to present and discuss her work at McGill [University] and UQAM [Université de Québec à Montréal] (CIRST) [Centre interuniversitaire de recherche sur la science et la technologie] and then to Toronto for discussions at York University, a University of Toronto IHPST [Institute for the History and Philosophy of Science and Technology] Brown Bag colloquium and a Wiegand Memorial Foundation Lecture on “Self-organization and God.” Select videos and podcasts of her public events are available on our website.

Dr. Anne Harrington, professor of History of Science at Harvard University, came to the Cluster Centre in October for a packed history of medicine luncheon conversation on “Culture in the Brain and Under the Skin”. This was followed by a post-performance discussion of placebo effect and medical attitudes and treatments after an original 2b Theatre production of “The Story of Mr. Wright.” Other recently supported events and visiting speakers to the Cluster Nodes include the Reading Artifacts Summer Institute at the Canada Science and Technology Museum (CSTM); Toronto’s Technoscience Salon on Ecologies; Women in Science and Engineering Symposium at McGiIll University; Dr. Suzanne Zeller, Wilfrid Laurier University in Halifax; Dr. Arun Bala, National University of Singapore at York University; Dr. Michael Lynch, Cornell University at U. Alberta [University of Alberta]; and many more.

…

II. UPCOMING WORKSHOPS, CONFERENCES AND EVENTS    

All of our events are supported by a host of partners and some are recorded, streamed live online or blogged about. Please visit our website for more information.

Fri. January 25, 5 PM, University of Toronto: “Technoscience Salon: Queer(y)ing Technologies.”

Wed., Feb. 27-28, National University of Singapore: “The Bright Dark Ages: Comparative and Connective Perspectives.”

Fri. Mar. 22-23, UBC [University of British Columbia]: Workshop on “Bodies in Motion: Translating Early Modern Science.”

Mon. April 1- Th. April 4, Calgary [University of Calgary], Edmonton [University of Alberta], Vancouver [University of British Columbia]: Dr. Evelyn Fox Keller continues her Node visits out west as the Cluster Visiting Scholar.

Fri. April 5, U. [University] King’s College: “Aelita: Queen of Mars” screening with live music.

Fri. Apr. 26-27, McGill University: McGill Node supports the Indian Ocean World Centreconference on “Histories of Medicine in the Indian Ocean.”

Fri. May. 3-4, York University: Conference on “Materiality: Objects and Idioms in Historical Studies of Science and Technology.”

Fri. Jun. 7-9, 2013, University of Calgary: Workshop on “Where is the Laboratory now? “Representation”, “Intervention” and “Realism” in 19th and 20th Century Biomedical Sciences.”

Mon. Oct. 21-23, 2013, U. Ottawa: Conference on “Science and Society.” In partnership with University of Ottawa’s Institute for Science, Society and Policy and the Professional Institute for the Public Service of Canada.

…

V. BLOGS, VIDEOS AND PODCASTS

Blogs: A fascinating array of blog entries on summer, fall and winter workshops, lectures and events are now available on our website here: www.situsci.ca/blog.

The entries treat topics as diverse as

  • “The Women Question in Science: Women in Science, Engineering and Medicine Symposium (WISEMS) 2012”,
  • “The Play’s the Thing: Putting History of Science on Stage”,
  • “The story I hold about myself: the epistemology of Mr. Wright”,
  • “Narrative Theory, Historical Ethics, Sound Reasoning Through Pseudo-Science, and Testing Implicit Bias: a day at the WISEMS”,
  • “A Week with the Wonder Photo Cannon”,
  • “Reflections on Reading Artifacts Summer Institute 2012”,
  • “Gender and the Digital Silo: Cultures of Knowledge at Situating Early Modern Science Networks Workshop” and
  • “Notes on Caring in a Technoscientific World”. Please feel free to share and comment.

Videos and Podcasts: Videos and podcasts of events are constantly uploaded and announced on our website and via our social media. The latest uploads include:

Evelyn Fox Keller speaking on “Self-Organization and God”, “Paradigm Shifts And Revolutions In Contemporary Biology” and “Legislating for Catastrophic Risk”.

Heinrich von Staden’s HOPOS 2012 presentation entitled “Experimentation in Ancient Science?”

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Simon Fraser University completes a successful mating dance while TRIUMF (Canada’s national laboratory for particle and nuclear physics) gets its groove on

Tuesday, January 15th, 2013

The Federal Government of Canada in the guise of the Canada Foundation for Innovation has just awarded $7.7M to Simon Fraser University (SFU) and its partners for a global innovation hub. From the Jan. 15, 2013 Canada Foundation for Innovation news release,

British Columbia’s research-intensive universities are coming together to create a global hub for materials science and engineering. Simon Fraser University, the University of Victoria, the University of British Columbia and the British Columbia Institute of Technology have received $7.7 million in funding from the Canada Foundation of Innovation to create the Prometheus Project — a research hub for materials science and engineering innovation and commercialization.

“Our goal with the Prometheus Project is to turn our world-class research capacity into jobs and growth for the people of British Columbia,” said Neil Branda, Canada Research Chair in Materials Science at Simon Fraser University and leader of the Prometheus Project. “We know that materials science is changing the way we create energy and fight disease. We think it can also help B.C.’s economy evolve.”

This project builds on a strong collective legacy of collaborating with industry. Researchers involved in the Prometheus Project have created 13 spin-off companies, filed 67 patents and have generated 243 new processes and products. [emphasis mine] Branda himself has founded a company called Switch Materials that seizes the power of advanced chemistry to create smarter and more efficient window coatings.

This funding will allow members of the research team to build their capacity in fabrication, device testing and advanced manufacturing, ensuring that they have the resources and expertise they need to compete globally.

There’s a bit more information about the Prometheus project in a Jan.15, 2013 backgrounder supplied by SFU,

Led by Neil Branda, a Canada Research Chair in Materials Science and SFU chemistry professor, The Prometheus Project is destined to become a research hub for materials science and engineering innovation, and commercialization globally.

It brings together 10 principal researchers, including Branda, co-founder of SFU’s 4D LABS (a materials research facility with capabilities at the nanoscale], and 20 other scientists at SFU, University of British Columbia, the University of Victoria and the British Columbia Institute of Technology. They will create new materials science and engineering (MS&E) technology innovations, which will trigger and support sustained economic growth by creating, transforming and making obsolete entire industries.

Working with internationally recognized industrial, government, hospital and academic collaborators, scientists at the Prometheus partners’ labs, including 4D LABS, a $40 million materials science research institute, will deliver innovations in three areas. The labs will:

  • Develop new solar-industry related materials and devices, including novel organic polymers, nanoparticles, and quantum dots, which will be integrated in low cost, high efficiency solar cell devices. The goal is to create a new generation of efficient solar cells that can compete in terms of cost with non-renewable technologies, surpassing older ones in terms of miniaturization and flexibility.
  • Develop miniaturized biosensors that can be used by individuals in clinical settings or at home to allow early detection of disease and treatment monitoring. They will be integrated into flexible electronic skins, allowing health conditions to be monitored in real-time.
  • Develop spintronics (magnetic devices) and quantum computing and information devices that will enable new approaches to significantly improve encrypted communication and security in financial transactions.

“This project will allow B.C.’s four most research intensive institutes to collaborate on fundamental materials research projects with a wide range of potential commercial applications,” notes Branda. “By engaging with a large community of industry, government and NGO partners, we will move this research out of the lab and into society to solve current and future challenges in important areas such as energy, health and communications.”

The Prometheus team already has a strong network of potential end users of resulting technologies. It is based on its members’ relationships with many of more than 25 companies in BC commercializing solar, biomedical and quantum computing devices.

Researchers and industries worldwide will be able to access Prometheus’s new capabilities on an open-access basis. [emphasis mine]

There are a few things I’d like to point out (a) 13 spin-off companies? There’s no mention as to whether they were successful, i.e., created jobs or managed a life beyond government funding. (b) Patents as an indicator for innovation? As I’ve noted many, many times that’s a very problematic argument to make. (c) New processes and products? Sounds good but there are no substantiating details.  (d) Given the emphasis on commercializing discoveries and business, can I assume that open-access to Prometheus’ capabilities means that anyone willing and able to pay can have access?

In other exciting SFU news which also affects TRIUMF, an additional $1M is being awarded by the Canada Foundation for Innovation to upgrade the ATLAS Tier-1 Data Analysis Centre. From the SFU backgrounder,

Led by Mike Vetterli, a physics professor at SFU and TRIUMF, this project involves collaborating with scientists internationally to upgrade a component of a global network of always-on computing centres. Collectively, they form the Worldwide Large Hadron Collider Computing Grid (WLCG).

The Canadian scientists collaborating with Vetterli on this project are at several research-intensive universities. They include Carleton University, McGill University, University of British Columbia, University of Alberta, University of Toronto, University of Victoria, Université de Montréal, and York University, as well as TRIUMF. It’s Canada’s national lab for particle and nuclear physics research.

The grid, which has 10 Tier-1 centres internationally, is essentially a gigantic storage and processing facility for data collected from the ATLAS  experiment. The new CFI funding will enable Vetterli and his research partners to purchase equipment to upgrade the Tier-1 centre at TRIUMF in Vancouver, where the equipment will remain.

ATLAS is a multi-purpose particle detector inside a massive atom-smashing collider housed at CERN, the world’s leading laboratory for particle physics in Geneva, Switzerland.

More than 3,000 scientists internationally, including Vetterli and many others at SFU, use ATLAS to conduct experiments aimed at furthering global understanding of how the universe was physically formed and operates.

The detector’s fame for being a window into nature’s true inner workings was redoubled last year. It helped scientists, including Vetterli and others at SFU, discover a particle that has properties consistent with the Higgs boson.

Peter Higgs, a Scottish physicist, and other scientists theorized in 1964 about the existence of the long-sought-after particle that is central to the mechanism that gives subatomic particles their mass.

Scientists now need to upgrade the WLCG to accommodate the massive volume of data they’re reviewing to confirm that the newly discovered particle is the Higgs boson. If it is, it will revolutionize the way we see mass in physics.

“This project will enable Canadian scientists to continue to play a leading role in ATLAS physics analysis projects such as the Higgs boson discovery,” says Vetterli. “Much more work and data are required to learn more about the Higgs-like particle and show that it is indeed the missing link to our understanding of the fundamental structure of matter.

There is one more Canada Foundation for Innovation grant to be announced here, it’s a $1.6M grant for research that will be performed at TRIUMF, according to the Jan. 13, 2013 news release from St. Mary’s University (Halifax, Nova Scotia),

Dr. Rituparna Kanungo’s newest research collaboration has some lofty goals: improve cancer research, stimulate the manufacturing of high-tech Canadian-made instrumentation and help explain the origin of the cosmos.

The Saint Mary’s nuclear physicist’s goal moved one step closer to reality today when the federal government announced $1.6 million in support for an advanced research facility that will allow her to recreate, purify, and condition rare isotopes that haven’t existed on the planet for millions of years.

The federal fiscal support from the Canada Foundation for Innovation together with additional provincial and private sector investment will allow the $4.5 million project to be operational in 2015.

“The facility will dramatically advance Canada’s capabilities for isolating, purifying, and studying short-lived isotopes that hold the key not only for understanding the rules that govern the basic ingredients of our everyday lives but also for crafting new therapies that could target and annihilate cancers cell-by-cell within the human body, “ said Dr Kanungo.

The CANadian Rare-isotope facility with Electron-Beam ion source (CANREB) project is led by Saint Mary’s University partnering with the University of Manitoba and Advanced Applied Physics Solutions, Inc. in collaboration with the University of British Columbia, the University of Guelph, Simon Fraser University, and TRIUMF. TRIUMF is Canada’s national laboratory for particle and nuclear physics. It is owned and operated as a joint venture by a consortium of Canadian universities that includes Saint Mary’s University.

…

As one of the nation’s top nuclear researchers (she was one of only two Canadians invited to speak at a Nobel Symposium last June about exotic isotopes), Dr. Kanungo has been conducting research at the TRIUMF facility for many years, carrying out analyses from her office at Saint Mary’s University together with teams of students. Her students also often spend semesters at the Vancouver facility.

As the project leader for the new initiative, she said TRIUMF is the ideal location because of its world leading isotope-production capabilities and its ability to produce clean, precise, controlled beams of selected exotic isotopes not readily available anywhere else in the world.

In recent studies in the U.S., some of these isotopes have been shown to have dramatic impact in treating types of cancer, by delivering radioactive payloads directly to the cancerous cells. Canada’s mastery of the technology to isolate, study, and control these isotopes will change the course of healthcare.

An integral part of the project is the creation of a new generation of high resolution spectrometer using precision magnets. Advanced Cyclotron Systems, Inc. a company in British Columbia, has been selected for the work with the hope that the expertise it develops during the venture will empower it to design and build precision-magnet technology products for cutting-edge projects all around the world.

Exciting stuff although it does seem odd that the federal government is spreading largesse when there’s no election in sight. In any case, bravo!

There’s one last piece of news, TRIUMF is welcoming a new member to its board, from its Jan. 14, 2013 news release,

Dr. Sylvain Lévesque, Vice-President of Corporate Strategy at Bombardier Inc., a world-leading manufacturer of innovative transportation solutions, has joined the Board of Management for TRIUMF, Canada’s national laboratory for particle and nuclear physics, for a three-year term.  Owned and operated by a consortium of 17 Canadian universities with core operating funds administered via a contribution agreement through National Research Council Canada, TRIUMF is guided by a Board that includes university vice-presidents of research, prestigious scientists, and leading members of Canada’s private sector.

Paul Young, Chair of TRIUMF’s Board and Vice President, Research at the University of Toronto, said, “We welcome the participation of Sylvain and his extensive experience at Bombardier.  TRIUMF is a national resource for basic research and yet we also fulfill a technological innovation mission for Canada.  Dr. Lévesque will be a valuable addition to the Board.”

Dr. Sylvain Lévesque earned his Ph.D. from MIT in Engineering and worked at McKinsey & Company before joining Bombardier in 1999.  He brings deep experience with large, technical organizations and a passion for science and engineering. [emphasis mine]  He said, “I am excited to work more closely with TRIUMF.  It has a track record of excellence and I am eager to provide guidance on where Canada’s industrial sector might draw greater strength from the laboratory.”

TRIUMF’s Board of Management reflects the unique status of TRIUMF, a laboratory operating for more than forty years as a joint venture from Canada’s leading research universities.  The consortium includes universities from Halifax to Victoria.

Is deep experience like wide experience or is it a whole new kind of experience helpful for ‘getting one’s groove on’? For anyone who’s curious, ‘getting one’s groove on’ involves dancing.

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Posted in electronics, energy, innovation, medicine, nanotechnology, science, science funding | 2 Comments »

Hydrogen ‘traffic jams’ and embrittlement

Tuesday, November 20th, 2012

Here’s something about how hydrogen atoms cause metals to become embrittled, from  a Nov. 19, 2012 McGill University (Montréal, Québec) news release,

Hydrogen, the lightest element, can easily dissolve and migrate within metals to make these otherwise ductile materials brittle and substantially more prone to failures.

Since the phenomenon was discovered in 1875, hydrogen embrittlement has been a persistent problem for the design of structural materials in various industries, from battleships to aircraft and nuclear reactors. Despite decades of research, experts have yet to fully understand the physics underlying the problem or to develop a rigorous model for predicting when, where and how hydrogen embrittlement will occur.  As a result, industrial designers must still resort to a trial- and-error approach.

Now, Jun Song, an Assistant Professor in Materials Engineering at McGill University, and Prof. William Curtin, Director of the Institute of Mechanical Engineering at Ecole Polytechnique Federale de Lausanne in Switzerland, have shown that the answer to hydrogen embrittlement may be rooted in how hydrogen modifies material behaviours at the nanoscale.  In their study, published in Nature Materials, Song and Curtin present a new model that can accurately predict the occurrence of hydrogen embrittlement.

Under normal conditions, metals can undergo substantial plastic deformation when subjected to forces. This plasticity stems from the ability of nano-  and micro-sized cracks to generate “dislocations” within the metal – movements of atoms that serve to relieve stress in the material.

“Dislocations can be viewed as vehicles to carry plastic deformation, while the nano- and micro-sized cracks can be viewed as hubs to dispatch those vehicles,” Song explains. “The desirable properties of metals, such as ductility and toughness, rely on the hubs functioning well.  Unfortunately those hubs also attract hydrogen atoms. The way hydrogen atoms embrittle metals is by causing a kind of traffic jam: they crowd around the hub and block all possible routes for vehicle dispatch. This eventually leads to the material breaking down.”

State-of-the-art computer simulations were performed by Song to reveal explicitly how hydrogen atoms move within metals and how they interact with metal atoms. This simulation was followed by rigorous kinetic analysis, to link the nanoscale details with macroscopic experimental conditions.

This model has been applied to predict embrittlement thresholds in a variety of ferritic iron-based steels and produced excellent agreements with experiments.  The findings provide a framework for interpreting experiments and designing next-generation embrittlement-resistant structural materials.

Here’s a citation for the paper and a link,

“Atomic mechanism and prediction of hydrogen embrittlement in iron” by Jun Song & W. A. Curtin in Nature Materials (2012) doi:10.1038/nmat3479 (advance online publication Nov.11, 2012)

This article is behind a paywall.

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Digitizing and visualizing the humanities

Friday, August 3rd, 2012

It’s a bit of stretch for this blog but since I sometimes write about ‘big’ data in the context of science, I’ve decided to include this piece on big data and the humanities. First, I looked up a definition for the humanities and it’s far broader than I expected, from the Wikipedia essay on the Humanities (Note: I have removed links),

The humanities are academic disciplines that study the human condition, using methods that are primarily analytical, critical, or speculative, as distinguished from the mainly empirical approaches of the natural sciences.

The humanities include ancient and modern languages, literature, history, philosophy, religion, and visual and performing arts such as music and theatre. Other humanities include social sciences, history, anthropology, area studies, communication studies, cultural studies, law and linguistics.

As for the digital humanities, here’s a brief description from the July 30, 2012 story about big data, the humanities, and Stéfan Sinclair, by Adam Bluestein for Fast Company,

In the burgeoning academic discipline of digital humanities, creating software tools is as important as getting published in a journal. To better understand what this means, take a peek at the pedagogical playbook of Stefan Sinclair, associate professor of digital humanities in McGill University’s Department of Languages, Literatures and Cultures.[Montréal, Québec, Canada] …

At the same time, he’s equipping a new generation of humanities students with the eclectic skill set and entrepreneurial spirit to take on a 21st century job market. …

FAST COMPANY: What is “digital humanities,” exactly?

STEFAN SINCLAIR: There’s a natural tendency to assume it’s a new field, but it’s actually been around for quite a long time. The first research combining computers and the humanities was in the 1940s, and a journal called Computers and Humanities started publishing in the 1960s. But there has been a lot of attention and momentum in the past 3 or 4 years that hasn’t been there before. The core of digital humanities is the critical exploration of how computers and technology can enhance but also influence our modes of research in traditional humanities.

My use of the word visualizing in the title for this posting differs from my general use of the term, i.e., make pictures/images from data (from the Bluestein article),

How does this kind of approach help us see things that we couldn’t before?

One thing that’s compelling about digital humanities is being able to ask questions at a scale you can’t ask without computers. Really, most humanities is very exclusionary–we don’t have time as humans to read a lot of text. So all English studies are a matter of excluding, choosing texts we’re interested in and leaving aside others. With computers, we can now ask questions of, say, all novels in the 19th century. Sometimes that’s called “distant reading”–as opposed to the more traditional literary practice of close reading. You can also combine close and distant reading, when you want to look at a few novels, but offer a comparison to a larger context of novels.

Digital humanities also encompasses a lot more than text. There is a lot of interest in game studies, for instance, and geospatial analysis that’s not what people in geography would do. An example of that is a project on the Republic of Letters–a long-distance intellectual community in the late 17th and 18th century in Europe and America–that maps the transferring of thoughts across geographical space, allowing you to visualize that and see things in generative ways.

Clearly, algorithm are influencing spheres of study and thought that would have been unthinkable recently for most of us, if not the pioneers of the 1940s. I’m glad to see Sinclair, towards the end of the article, discuss one of the dangers of digitizing humanities, i.e., turning the humanities into an hypothesis-proving endeavour (scientific method). From the Bluestein article,

I am particularly passionate about tools and methodologies that allow for the proliferation of perspectives–not to prove a hypothesis I have, but to see a text differently and ask different questions.

I was once asked to define my writing practice as part of a presentation. My answer (I’m sparing your 10 mins. of presentation) was this: asking questions.

You can find out more bout Stéfan Sinclair and his work here.

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Posted in New Media | 1 Comment »

Greener catalysts with iron nanoparticles

Wednesday, March 28th, 2012

A research team at the University of Toronto has announced the discovery of a possible ‘green’ alternative to commonly used catalysts in the food, drug, and fragrance industries. From the March 27, 2012 news item on Nanowerk,

A chemistry team at the University of Toronto has discovered environmentally-friendly iron-based nanoparticle catalysts that work as well as the expensive, toxic, metal-based catalysts that are currently in wide use by the drug, fragrance and food industry.

“It is always important to strive to make industrial syntheses more green, and using iron catalysts is not only much less toxic, but it is also much more cost effective,” said Jessica Sonnenberg, a PhD student and lead author of a paper published this week in the Journal of the American Chemical Society (“Iron Nanoparticles Catalyzing the Asymmetric Transfer Hydrogenation of Ketones”).

The March 27, 2012 University of Toronto news release provides a quote from Sonnenberg which suggests there’s still a lot more work to be done before the toxic metal-based catalysts currently being used could be replaced,

… “Catalysts, even cheap iron ones developed for these types of reaction, still suffer one major downfall,” explained Sonnenberg.  “They require a one-to-one ratio of very expensive organic ligands – the molecule that binds to the central metal atom of a chemical compound – to yield catalytic activity. Our discovery of functional surface nanoparticles opens the door to using much smaller ratios of these expensive compounds relative to the metal centres.  This drastically reduces the overall cost of the transformations.”

This work at the University of Toronto reminded me of another team also working on green catalysts for chemical reactions and also based in Canada, this time at McGill University. The McGill team lead by Chao-Jun Li was mentioned most recently here in a Jan. 10, 2011 posting where their ‘nanomagnetics’ technology to replace the current toxic catalysts  is described.

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Posted in beauty and cosmetics, nanotechnology, pharmacology | No Comments »

Nanocellulose at the American Chemical Society’s 243rd annual meeting

Tuesday, March 27th, 2012

Nanocellulose seems to be one of the major topics at the ACS’s (Americal Chemical Society) 243rd annual meeting themed Chemistry of Life  in San Diego, California, March 25-29, 2012. From the March 25, 2012 news item on Nanowerk,

… almost two dozen reports in the symposium titled, “Cellulose-Based Biomimetic and Biomedical Materials,” that focused on the use of specially processed cellulose in the design and engineering of materials modeled after biological systems. Cellulose consists of long chains of the sugar glucose linked together into a polymer, a natural plastic–like material. Cellulose gives wood its remarkable strength and is the main component of plant stems, leaves and roots. Traditionally, cellulose’s main commercial uses have been in producing paper and textiles –– cotton being a pure form of cellulose. But development of a highly processed form of cellulose, termed nanocellulose, has expanded those applications and sparked intense scientific research. Nanocellulose consists of the fibrils of nanoscale diameters so small that 50,000 would fit across the width of the period at the end of this sentence.

“We are in the middle of a Golden Age, in which a clearer understanding of the forms and functions of cellulose architectures in biological systems is promoting the evolution of advanced materials,” said Harry Brumer, Ph.D., of Michael Smith Laboratories, University of British Columbia, Vancouver. He was a co-organizer of the symposium with J. Vincent Edwards, Ph.D., a research chemist with the Agricultural Research Service, U.S. Department of Agriculture in New Orleans, Louisiana. “This session on cellulose-based biomimetic and biomedical materials is really very timely due to the sustained and growing interest in the use of cellulose, particularly nanoscale cellulose, in biomaterials.”

One of the presenters has a very charming way of describing the nanocellulose product his team is working on (from the news item),

Olli Ikkala, Ph.D., [Aalto University, Finland] described the new buoyant material, engineered to mimic the water strider’s long, thin feet and made from an “aerogel” composed of the tiny nano-fibrils from the cellulose in plants. Aerogels are so light that some of them are denoted as “solid smoke. [emphasis mine]” The nanocellulose aerogels also have remarkable mechanical properties and are flexible.

There were some 20 presentations in this symposium held under the auspices of the ACS annual meeting. Here’s a few of the presentations (some of these folks have been featured on this blog previously), from the news item,

Native cellulose nanofibers: From biomimetic nanocomposites to functionalized gel spun fibers and functional aerogels Olli Ikkala, Professor, PhD, Aalto University, P.O. Box 5100, Espoo, Finland, FIN-02015, Finland , 358-9-470 23154, olli.ikkala@aalto.fi Native cellulose nanofibers and whiskers attract interest even beyond the traditional cellulose community due to their mechanical properties, availability and sustainability. We describe biomimetic nanocomposites with aligned self-assemblies combining nanocellulose with nanoclays, polymers, block copolymer, or graphene, allowing exciting mechanical properties. Functional ductile and even flexible aerogels are presented, combining superhydrophobicity, superoleophobicity, oil-spill absorption, photocatalytics, optically switchable water absorption, sensing, and antimicrobial properties. Finally mechanically excellent fibers are gel-spun and functionalized for electric, magnetic, optical and drug-release properties.

Evaluation of skin tissue repair materials from bacterial cellulose Lina Fu, Miss, Huazhong University of Science & Technology, College of Life Science & Technology, 1037 Luoyu Road, Wuhan, Hubei, 430074, China , 86-18971560696, runa0325@gmail.com Bacterial cellulose (BC) has been reported as the materials in the tissue engineering fields, such as skin, bone, vascular and cartilage tissue engineering. Exploitation of the skin substitutes and modern wound dressing materials by using BC has attracted much attention. A skin tissue repair materials based on BC have been biosynthesized by Gluconacetobacter xylinus. The nano-composites of BC and chitosan form a cohesive gel structure, and the cell toxicity of the composite is excellent. Unlike other groups, which showed more inflammatory behavior, the inflammatory cells of the BC group were mainly polymorph-nuclear and showed few lymphocytes. The BC skin tissue repair material has an obviously curative effect in promoting the healing of epithelial tissue and reducing inflammation. With its superior mechanical properties, and the excellent biocompatibility, these skin tissue repair materials based on BC have great promise and potential for wound healing and very high clinical value.

….

New materials from nanocrystalline cellulose Mark MacLachlan [mentioned in my Nov. 18, 2010 posting], University of British Columbia, Department of Chemistry, 2036 Main Mall, Vancouver, BC, V6T 1Z1, Canada , 604-822-3070, mmaclach@chem.ubc.ca Nanocrystalline cellulose (NCC) is available from the acid-catalyzed degradation of cellulosic materials. NCC is composed of cylindrical crystallites with diameters of ca. 5-10 nm and large aspect ratios. This form of cellulose has intriguing properties, including its ability to form a chiral nematic structure. By using the chiral nematic organization of NCC as a template, we have been able to create highly porous silica films and carbon films with chiral nematic organization.1,2 These materials are iridescent and their structures mimic the shells of jewel beetles. In this paper, I will describe our recent efforts to use NCC to create new materials with interesting optical properties.

Factors influencing chiral nematic pitch and texture of cellulose nanocrystal films Derek G Gray, McGill University, Department of Chemistry, Pulp and Paper Building, 3420 University Street, Montreal, QC, H3A 2A7, Canada , 1-514-398-6182, derek.gray@mcgill.ca Appropriately stabilized cellulose nanocrystal (NCC) suspensions in water form chiral nematic liquid crystalline phases above some critical concentration. In the absence of added electrolye, the chiral nematic pitch of such suspensions is longer than that of visible light. Films prepared by evaporation from the suspensions also often display the characteristic fingerprint patterns characteristic of long-pitch chiral nematic phases, but the pitch values can be shifted into the visible range by adding small quantities of electrolyte to the evaporating suspension. The factors that control the final pitch have been the subject of some confusion. While still not well understood, it is clear that at high nanocrystal concentrations and in solid films, the pitch is not simply a reversible function of nanocrystal concentration. We examine some of the factors that control the pitch and liquid crystal texture during the drying of chiral nematic NCC films.

….

Bioprinting of 3D porous nanocellulose scaffolds for tissue engineering and organ regeneration Paul Gatenholm, Professor, [mentioned in my March 19, 2012 posting] Wallenberg Wood Science Center, Chalmers, Department of Chemical and Biological Engineering, Kemigarden 4, Goteborg, V. Gotaland, SE41296, Sweden , 46317723407, paul.gatenholm@chalmers.se Nanocellulose is a promising biocompatible hydrogel like nano-biomaterial with potential uses in tissue engineering and regenerative medicine. Biomaterial scaffolds for tissue engineering require precise control of porosity, pore size, and pore interconnectivity. Control of scaffold architecture is crucial to promote cell migration, cell attachment, cell proliferation and cell differentiation. 3D macroporous nanocellulose scaffolds, produced by unique biofabrication process using porogens incorporated in the cultivation step, have shown ability to attract smooth muscle cells, endothelial cells, chondrocytes of various origins, urethral cells and osteoprogenitor cells. We have developed bioprinter which is able to produce 3D porous nanocellulose scaffolds with large size and unique architecture. Surface modifications have been applied to enhance cell adhesion and cell differentiation. In this study we have focused on use of 3D porous Nanocellulose scaffolds for stem cell differentiation into osteogenic and chondral lineages.

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Posted in biomimcry, medicine, nanotechnology | 1 Comment »

Grand Challenges, point-of-care diagnostics, and a note on proliferating bureaucracies

Thursday, December 22nd, 2011

Last week, the Bill & Melinda Gates Foundation announced a $21.1 M grant over three years for research into point-of-care diagnostic tools for developing nations. A Canadian nongovermental organization (NGO) will be supplementing this amount with $10.8 M for a total of $31.9 M. (source: Dec. 16, 2011 AFP news item [Agence France-Presse] on MedicalXpress.com)

At this point, things get a little confusing. The Bill & Melinda Gates Foundation has a specific program called Grand Challenges in Global Health and this grant is part of that program. Plus, the Canadian NGO is called Grand Challenges Canada (couldn’t they have found a more distinctive name?), which is funded by a federal Canadian government initiative known as the Development Innovation Fund (DIF). Here’s a little more from the Who We Are page,

In the 2008 Federal Budget the Government of Canada announced the creation of the Development Innovation Fund (DIF) to “support the best minds in the world as they search for breakthroughs in global health and other areas that have the potential to bring about enduring changes in the lives of the millions of people in poor countries.” The Government of Canada is committing $225 million over five years to the Development Innovation Fund.

The Development Innovation Fund will be delivered by Grand Challenges Canada working with the International Development Research Centre (IDRC) and the Canadian Institutes of Health Research (CIHR). As the Government of Canada’s lead on the Development Innovation Fund, the International Development Research Centre will draw on decades of experience managing research projects and ensure that developing country researchers and concerns are front and centre in this exciting new initiative. The initial activities of the Development Innovation Fund will be in global health.

Grand Challenges Canada is a unique and independent not-for-profit organization dedicated to improving the health and well-being of people in developing countries by integrating scientific, technological, business and social innovation both in Canada and in the developing world. Grand Challenges Canada works with the International Development Research Centre, Canadian Institutes of Health Research, and other global health foundations and organizations committed to discovering sustainable solutions to the world’s most pressing health challenges. Grand Challenges Canada is hosted by the McLaughlin-Rotman Centre for Global Health, University Health Network and University of Toronto.

So if I understand this rightly, the Canadian federal government created a new fund and then created a new NGO to administer that fund. I wonder how much money is required administratively for this NGO which exists solely to distribute DIF. I’m glad to see that someone is getting some money for research out of this but it does seem labyrinthine at best.

On a happier, more productive now, here’s the type of research this money will be used for (from the MedicalXpress.com news item),

“Imagine a hand-held, battery-powered device that can take a drop of blood and, within minutes, tell a healthcare worker in a remote village whether a feverish child has malaria, dengue or a bacterial infection,” said Peter Singer, head of Grand Challenges Canada which is partnering with the Microsoft founder Bill Gates’s charitable organization on the project.

In this last year I have posted a few times about similar projects for handheld diagnostic devices, in my Aug. 4, 2011 posting ‘Diagnostics on a credit card‘ and in my Feb. 15, 2011 posting ‘Argento, nano, and PROOF‘. There’s a lot of interest in these devices whether they’re intended for use in developing countries or not.

I have tracked down the Dec. 15, 2011 news release from the Bill & Melinda Gates Foundation to get more details about this specific project,

The grants announced today are part of the Point-of-Care Diagnostics (POC Dx) Initiative, a research and development program with the goal of creating new diagnostic platforms that enable high-quality, low-cost diagnosis of disease, and also facilitate sustainable markets for diagnostic products, a key challenge in the developing world. This first phase of the POC Dx Initiative is focused on developing new technologies and identifying implementation issues to address the key barriers for clinical diagnostics in the developing world.

They also give some examples of projects that will be receiving funding from this grant,

Examples of projects receiving funding:

  • Seventh Sense Biosystems, a company located in Cambridge MA, is developing TAP—a painless, low-cost blood collection device which aims to allow easy, push-button sampling of blood. This simple collection process would reduce training requirements and enable diagnostics closer to the point of need.
  • David Beebe and researchers at the University of Wisconsin are developing a sample purification system that seeks to better filter and concentrate biomarkers from patient samples. This system will be designed for use in impoverished settings.
  • Axel Scherer of the California Institute of Technology, along with collaborators at Dartmouth College, will develop a prototype quantitative PCR (qPCR) amplification/detection component module—a low cost, easy-to-use technology that can rapidly detect a wide range of diseases.

There’s additional detail about grantees in the Grand Challenges Canada Dec. 16, 2011 news release,

One grantee, Bigtec Labs in Bangalore, India, has already developed a handheld analyser called a mini-PCR (Polymerase Chain Reaction) machine capable of identifying malaria from a DNA fingerprint.

―A colleague here one day was ill with what he thought was food poisoning,” said

B. Chandrasekhar Nair, Director of Bigtec Labs. “We ran a blood sample through our mini-PCR and it turned out to be malaria.‖ Immediately treated, the colleague returned to health within a week.

With its CAD $1.3 million grant, Bigtec will use nano-materials to develop a sophisticated filter to concentrate pathogen DNA from samples of blood, sputum, urine, or nasal and throat swabs. Once concentrated, the DNA can be processed and illnesses identified in the mini-PCR.

The innovative projects receiving funding include:

 Dr. Dhananjaya Dendukuri from Achira Labs in Bangalore India, and Dr. Nandini Dendukuri from McGill University in Montreal are developing a piece of silk that can be used as a cost-effective and simple diagnostic for blood and urine samples. Called Fabchips (Fabric Chips) the woven diagnostic has the added benefit of providing jobs to local artisans and being environmentally friendly.

 Dr. David Goldfarb, a Canadian working in Botswana, is testing a simple, rapid, easy-to-use swab for the detection of diarrheal disease in the developing world.

 Dr. Wendy Stevens from the University of Witwatersrand in South Africa is testing new point-of-care technologies for the integrated management of HIV and TB treatment to encourage equity, affordability and accessibility to treatment.

 Dr. Patricia Garcia at the Universidad Peruana Cayetano Heredia in Peru will look at ways to overcome social and commercial barriers to delivering point-of-care diagnostic tests aimed at improving maternal and child health – two of the UN‘s Millennium Development goals for 2015.

There’s a full list of all the grantees (Grand Challenges Canada and the Bill & Melinda Gates Foundation) and links to videos here.

Here’s a sample video of Dr. Dhananjaya Dendukuri to get you started,

Congratulations to the researchers!

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Posted in medicine, nanotechnology | 3 Comments »

Quelle drag! McGill research team develops tiny (150 atoms) electronic circuits

Wednesday, December 7th, 2011

Drag and heat—sounds like a car race, doesn’t it? It’s all about electronics and some nanoscale work by researchers at McGill University (Montréal, Canada). From the Dec. 7, 2011 McGill news release,

A team of scientists, led by Guillaume Gervais from McGill’s Physics Department and Mike Lilly from Sandia National Laboratories, has engineered one of the world’s smallest electronic circuits. It is formed by two wires separated by only about 150 atoms or 15 nanometers (nm).

The paper is available behind Nature’s paywall or you can view the abstract for Positive and negative Coulomb drag in vertically integrated one-dimensional quantum wires. Excerpted from the abstract,

Electron interactions in and between wires become increasingly complex and important as circuits are scaled to nanometre sizes, or use reduced-dimensional conductors such as carbon nanotubes, nanowiresand gated high-mobility two-dimensional electron systems. This is because the screening of the long-range Coulomb potential of individual carriers is weakened in these systems, which can lead to phenomena such as Coulomb drag, where a current in one wire induces a voltage in a second wire through Coulomb interactions alone.

The  news release addresses the Coulomb drag in more accessible (for some of us) language,

This is the first time that anyone has studied how the wires in an electronic circuit interact with one another when packed so tightly together. Surprisingly, the authors found that the effect of one wire on the other can be either positive or negative. This means that a current in one wire can produce a current in the other one that is either in the same or the opposite direction. This discovery, based on the principles of quantum physics, suggests a need to revise our understanding of how even the simplest electronic circuits behave at the nanoscale.

In addition to the effect on the speed and efficiency of future electronic circuits, this discovery could also help to solve one of the major challenges facing future computer design. This is managing the ever-increasing amount of heat produced by integrated circuits.

According to the news release, this discovery could have an impact on a wide range of electronics including smartphones, desktop computers, televisions, and GPS systems. Congratulations to the McGill team: D. Laroche, G. Gervais, M. P. Lilly, and J. L. Reno.

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Posted in electronics, nanotechnology | No Comments »

Canada-Japan Nanotechnology Workshop at the University of Waterloo

Monday, November 21st, 2011

Today (Nov. 21, 2011) and tomorrow (Nov. 22), the Waterloo Institute for Nanotechnology (WIN) at the University of Waterloo is hosting a nanotechnology workshop celebrating the 25th anniversary of the Canada-Japan Agreement on Cooperation in Science and Technology. The Honourable Gary Goodyear Minister of State (Science and Technology) gave the opening remarks (from the Nov. 21, 2011 news release on the Industry Canada website),

“There are tremendous opportunities for international researchers and businesses to come to Canada and invest in research and development,” said Minister of State Goodyear. “This conference allows us to showcase opportunities in nanotechnology and promote stronger linkages with Canadian researchers and innovators. The relationship we are building will benefit the Canadian and Japanese economies.”

The conference drew a number of high-profile delegates, including His Excellency Kaoru Ishikawa, Ambassador of Japan to Canada and Mr. Yasuyoshi Kakita, Director of the Generic Research and Research Platform Division of Japan’s Ministry of Education, Culture, Sports, Science and Technology.

WIN’s workshop webpage offers more details about the Canada-Japan relationship and our mutual interest in nanotechnology,

Nanotechnology is identified in both countries as a priority area by the Expert Advisory Group (EAG) on Canada-Japan S&T Cooperation. Four major nanotechnology collaborations were recently identified by the Embassies of Japan and Canada for their on-going execution of annual workshops, proven mobility and exchange programs, research funding and number of projects initiated. These are: (in order of MOU signing).

- National Institute for Nanotechnology (NINT) & National Institute of Advanced Industrial Science and Technology (AIST) – 2006
- NanoQuebec & Nagano Techno Foundation – 2009
- Waterloo Institute for Nanotechnology (WIN) & National Institute for Materials Science (NIMS) – 2010
- McGill University & RIKEN – 2010

The Canada-Japan nanotechnology workshop is designed to bring Canadian and Japanese stakeholders together to highlight their success at a national level and for individual researcher teams to advance their collaborative projects. Scientists including Canadian Research Chairs in the field of nanotechnology, government representatives and administrators from leading universities and nanotechnology organizations will be on hand to discuss the future of nanotechnology and recommend paths ahead.

By coming together we will help define a nanotechnology road map for Canada and Japan cooperation that will identify future areas for research funding, commercialization and trade for our respective Governments and Embassies. [emphasis mine]

I’m not sure how they’re going to be able to define a nanotechnology road map for cooperation with Japan when there isn’t any kind of nanotechnology roadmap for Canada. You can check that out for yourself here.

I hope there will be more news from the workshop as it progresses.

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Posted in nanotechnology | No Comments »

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