Tag Archives: Oliver G. Schmidt

Living technology possibilities

Before launching into the possibilities, here are two descriptions of ‘living technology’ from the European Centre for Living Technology’s (ECLT) homepage,

Goals

Promote, carry out and coordinate research activities and the diffusion of scientific results in the field of living technology. The scientific areas for living technology are the nano-bio-technologies, self-organizing and evolving information and production technologies, and adaptive complex systems.

History

Founded in 2004 the European Centre for Living Technology is an international and interdisciplinary research centre established as an inter-university consortium, currently involving 18 European and extra-European institutional affiliates.

The Centre is devoted to the study of technologies that exhibit life-like properties including self-organization, adaptability and the capacity to evolve.

Despite the reference to “nano-bio-technologies,” this October 11, 2023 news item on ScienceDaily focuses on microscale living technology,

It is noIn a recent article in the high-profile journal “Advanced Materials,” researchers in Chemnitz show just how close and necessary the transition to sustainable living technology is, based on the morphogenesis of self-assembling microelectronic modules, strengthening the recent membership of Chemnitz University of Technology with the European Centre for Living Technology (ECLT) in Venice.

An October 11, 2023 Chemnitz University of Technology (Technische Universität Chemnitz; TU Chemnitz) press release (also on EurekAlert), which originated the news item, delves further into the topic, Note: Links have been removed,

It is now apparent that the mass-produced artefacts of technology in our increasingly densely populated world – whether electronic devices, cars, batteries, phones, household appliances, or industrial robots – are increasingly at odds with the sustainable bounded ecosystems achieved by living organisms based on cells over millions of years. Cells provide organisms with soft and sustainable environmental interactions with complete recycling of material components, except in a few notable cases like the creation of oxygen in the atmosphere, and of the fossil fuel reserves of oil and coal (as a result of missing biocatalysts). However, the fantastic information content of biological cells (gigabits of information in DNA alone) and the complexities of protein biochemistry for metabolism seem to place a cellular approach well beyond the current capabilities of technology, and prevent the development of intrinsically sustainable technology.

SMARTLETs: tiny shape-changing modules that collectively self-organize to larger more complex systems

A recent perspective review published in the very high impact journal Advanced Materials this month [October 2023] by researchers at the Research Center for Materials, Architectures and Integration of Nanomembranes (MAIN) of Chemnitz University of Technology, shows how a novel form of high-information-content Living Technology is now within reach, based on microrobotic electronic modules called SMARTLETs, which will soon be capable of self-assembling into complex artificial organisms. The research belongs to the new field of Microelectronic Morphogenesis, the creation of form under microelectronic control, and builds on work over the previous years at Chemnitz University of Technology to construct self-folding and self-locomoting thin film electronic modules, now carrying tiny silicon chiplets between the folds, for a massive increase in information processing capabilities. Sufficient information can now be stored in each module to encode not only complex functions but fabrication recipes (electronic genomes) for clean rooms to allow the modules to be copied and evolved like cells, but safely because of the gating of reproduction through human operated clean room facilities.

Electrical self-awareness during self-assembly

In addition, the chiplets can provide neuromorphic learning capabilities allowing them to improve performance during operation. A further key feature of the specific self-assembly of these modules, based on matching physical bar codes, is that electrical and fluidic connections can be achieved between modules. These can then be employed, to make the electronic chiplets on board “aware” of the state of assembly, and of potential errors, allowing them to direct repair, correct mis-assembly, induce disassembly and form collective functions spanning many modules. Such functions include extended communication (antennae), power harvesting and redistribution, remote sensing, material redistribution etc.

So why is this technology vital for sustainability?

The complete digital fab description for modules, for which actually only a limited number of types are required even for complex organisms, allows their material content, responsible originator and environmentally relevant exposure all to be read out. Prof. Dagmar Nuissl-Gesmann from the Law Department at Chemnitz University of Technology observes that “this fine-grained documentation of responsibility intrinsic down to microscopic scales will be a game changer in allowing legal assignment of environmental and social responsibility for our technical artefacts”.

Furthermore, the self-locomotion and self-assembly-disassembly capabilities allows the modules to self-sort for recycling. Modules can be regained, reused, reconfigured, and redeployed in different artificial organisms. If they are damaged, then their limited and documented types facilitate efficient custom recycling of materials with established and optimized protocols for these sorted and now identical entities. These capabilities complement the other more obvious advantages in terms of design development and reuse in this novel reconfigurable media. As Prof. Marlen Arnold, an expert in Sustainability of the Faculty of Economics and Business Administration observes, “Even at high volumes of deployment use, these properties could provide this technology with a hitherto unprecedented level of sustainability which would set the bar for future technologies to share our planet safely with us.”

Contribution to European Living Technology

This research is a first contribution of MAIN/Chemnitz University of Technology, as a new member of the European Centre for Living Technology ECLT, based in Venice,” says Prof. Oliver G. Schmidt, Scientific Director of the Research Center MAIN and adds that “It’s fantastic to see that our deep collaboration with ECLT is paying off so quickly with immediate transdisciplinary benefit for several scientific communities.” “Theoretical research at the ECLT has been urgently in need of novel technology systems able to implement the core properties of living systems.” comments Prof. John McCaskill, coauthor of the paper, and a grounding director of the ECLT in 2004.

Here’s a link to and a citation for the researchers’ perspective paper,

Microelectronic Morphogenesis: Smart Materials with Electronics Assembling into Artificial Organisms by John S. McCaskill, Daniil Karnaushenko, Minshen Zhu, Oliver G. Schmidt. Advanced Materials DOI: https://doi.org/10.1002/adma.202306344 First published: 09 October 2023

This paper is open access.

Spermbot alternative for infertility issues

A German team that’s been working with sperm to develop a biological motor has announced it may have an alternative treatment for infertility, according to a Jan. 13, 2016 news item on Nanowerk,

Sperm that don’t swim well [also known as low motility] rank high among the main causes of infertility. To give these cells a boost, women trying to conceive can turn to artificial insemination or other assisted reproduction techniques, but success can be elusive. In an attempt to improve these odds, scientists have developed motorized “spermbots” that can deliver poor swimmers — that are otherwise healthy — to an egg. …

A Jan. 13, 2016 American Chemical Society (ACS) news release (*also on EurekAlert*), which originated the news item, expands on the theme,

Artificial insemination is a relatively inexpensive and simple technique that involves introducing sperm to a woman’s uterus with a medical instrument. Overall, the success rate is on average under 30 percent, according to the Human Fertilisation & Embryology Authority of the United Kingdom. In vitro fertilization can be more effective, but it’s a complicated and expensive process. It requires removing eggs from a woman’s ovaries with a needle, fertilizing them outside the body and then transferring the embryos to her uterus or a surrogate’s a few days later. Each step comes with a risk for failure. Mariana Medina-Sánchez, Lukas Schwarz, Oliver G. Schmidt and colleagues from the Institute for Integrative Nanosciences at IFW Dresden in Germany wanted to see if they could come up with a better option than the existing methods.

Building on previous work on micromotors, the researchers constructed tiny metal helices just large enough to fit around the tail of a sperm. Their movements can be controlled by a rotating magnetic field. Lab testing showed that the motors can be directed to slip around a sperm cell, drive it to an egg for potential fertilization and then release it. The researchers say that although much more work needs to be done before their technique can reach clinical testing, the success of their initial demonstration is a promising start.

For those who prefer to watch their news, there’s this,


This team got a flurry of interest in 2014 when they first announced their research on using sperm as a biological motor. Tracy Staedter in a Jan. 15, 2014 article for Discovery.com describes their then results,

To create these tiny robots, the scientists first had to catch a few. First, they designed microtubes, which are essentially thin sheets of titanium and iron — which have a magnetic property — rolled into conical tubes, with one end wider than the other. Next, they put the microtubes into a solution in a Petri dish and added bovine sperm cells, which are similar size to human sperm. When a live sperm entered the wider end of the tube, it became trapped down near the narrow end. The scientists also closed the wider end, so the sperm wouldn’t swim out. And because sperm are so determined, the trapped cell pushed against the tube, moving it forward.

Next, the scientists used a magnetic field to guide the tube in the direction they wanted it to go, relying on the sperm for the propulsion.

The quick swimming spermbots could use controlled from outside a person body to deliver payloads of drugs and even sperm itself to parts of the body where its needed, whether that’s a cancer tumor or an egg.

This work isn’t nanotechnology per se but it has been published in ACS Nano Letters. Here’s a link to and a citation for the paper,

Cellular Cargo Delivery: Toward Assisted Fertilization by Sperm-Carrying Micromotors by Mariana Medina-Sánchez, Lukas Schwarz, Anne K. Meyer, Franziska Hebenstreit, and Oliver G. Schmidt. Nano Lett., 2016, 16 (1), pp 555–561 DOI: 10.1021/acs.nanolett.5b04221 Publication Date (Web): December 21, 2015

Copyright © 2015 American Chemical Society

This paper is behind a paywall.

*'(also on EurekAlert)’ text and link added Jan. 14, 2016.