Tag Archives: PET

The gold beneath your skin (artificial skin, that is)

Artificial skin that can sense as if it were real skin isn’t here yet but scientists at Technion-Israel Institute of Technology have created a flexible sensor that could fulfill that promise. From a July 9, 2013 news item on Azonano,

Using tiny gold particles and a kind of resin, a team of scientists at the Technion-Israel Institute of Technology has discovered how to make a new kind of flexible sensor that one day could be integrated into electronic skin, or e-skin.

If scientists learn how to attach e-skin to prosthetic limbs, people with amputations might once again be able to feel changes in their environments. The findings appear in the June issue of ACS Applied Materials & Interfaces.

The July 8, 2013 American Technion Society news release by Kevin Hattori, which originated the news item, describes the problems with developing flexible sensors that can mimic natural skin,

Researchers have long been interested in flexible sensors, but have had trouble adapting them for real-world use. To make its way into mainstream society, a flexible sensor would have to run on low voltage (so it would be compatible with the batteries in today’s portable devices), measure a wide range of pressures, and make more than one measurement at a time, including humidity, temperature, pressure, and the presence of chemicals. In addition, these sensors would also have to be able to be made quickly, easily, and cheaply.

Here are more details about the sensor and about how the researchers created it,

The Technion team’s sensor has all of these qualities. The secret is the use of monolayer-capped nanoparticles that are only 5-8 nanometers in diameter. They are made of gold and surrounded by connector molecules called ligands. In fact, “monolayer-capped nanoparticles can be thought of as flowers, where the center of the flower is the gold or metal nanoparticle and the petals are the monolayer of organic ligands that generally protect it,” says Haick.

The team discovered that when these nanoparticles are laid on top of a substrate – in this case, made of PET (flexible polyethylene terephthalate), the same plastic found in soda bottles – the resulting compound conducted electricity differently depending on how the substrate was bent. (The bending motion brings some particles closer to others, increasing how quickly electrons can pass between them.) This electrical property means that the sensor can detect a large range of pressures, from tens of milligrams to tens of grams. “The sensor is very stable and can be attached to any surface shape while keeping the function stable,” says Dr. Nir Peled, Head of the Thoracic Cancer Research and Detection Center at Israel’s Sheba Medical Center, who was not involved in the research.

And by varying how thick the substrate is, as well as what it is made of, scientists can modify how sensitive the sensor is. Because these sensors can be customized, they could in the future perform a variety of other tasks, including monitoring strain on bridges and detecting cracks in engines.

According to research team leader Professor Hossam Haick the new sensor is more sensitive (x 10 or more) in touch than existing touch-based e-skin.

Here’s a link to and a citation for the published paper,

Tunable Touch Sensor and Combined Sensing Platform: Toward Nanoparticle-based Electronic Skin by Meital Segev-Bar , Avigail Landman, Maayan Nir-Shapira, Gregory Shuster, and Hossam Haick. ACS Appl. Mater. Interfaces, 2013, 5 (12), pp 5531–5541 DOI: 10.1021/am400757q Publication Date (Web): June 4, 2013

Copyright © 2013 American Chemical Society

The paper is behind a paywall.

Watching zinc, iron, and copper molecules real-time as they interact with biomolecules

Eventually they’re hoping this work will lead to insights about diabetes and cancer. In the meantime, researchers at RIKEN Center for Life Science Technologies (Japan) have developed a new imaging technique that allows them to observe metal molecules interacting with biomolecules in real-time. From the May 2, 2013 news release on EurekAlert,

Metal elements and molecules interact in the body but visualizing them together has always been a challenge. Researchers from the RIKEN Center for Life Science Technologies in Japan have developed a new molecular imaging technology that enables them to visualize bio-metals and bio-molecules simultaneously in a live mouse. This new technology will enable researchers to study the complex interactions between metal elements and molecules in living organisms.

It’s well known we need zinc, iron, and copper in our bodies for proper functioning. Until now, no one has been able to observe the interaction in real-time, from the RIKEN May 2, 2013 press release (which originated the EurekAlert news release),

In the study, the researchers were able to visualise two radioactive agents injected in a tumor-bearing mouse, as well as an anti-tumor antibody labelled with a PET molecular probe agent, simultaneously in the live mouse.

This new revolutionary technology is expected to offer new insights into the relationships between bio-metal elements and associated bio-molecules, and the roles they play in diseases such as diabetes and cancer.

The researchers had to create a camera capable of visualizing the interactions (from the RIKEN press release),

Dr. Shuichi Enomoto, Dr. Shinji Motomura and colleagues, from the RIKEN Center for Life Science Technologies have developed a gamma-ray imaging camera enabling them to detect the gamma-rays emitted by multiple bio-metal elements in the body and study their behavior.

Their second prototype of the system, called GREI–II and presented today in the Journal of Analytical Atomic Spectrometry, enables them to visualize multiple bio-metal elements more than 10 times faster than before, and to do so simultaneously with positron emission tomography (PET).

You can find the research study here.

For those unfamiliar with RIKEN, here’s more from their About RIKEN page,

RIKEN is Japan’s largest comprehensive research institution renowned for high-quality research in a diverse range of scientific disciplines. Founded in 1917 as a private research foundation in Tokyo, RIKEN has grown rapidly in size and scope, today encompassing a network of world-class research centers and institutes across Japan.

RFID (radio frequency indentification) tag on a single sheet of paper?

RFID tags are used to track all kinds of things and according to this Wikipedia essay, even people,

Radio-frequency identification (RFID) is the use of a wireless non-contact radio system to transfer data from a tag attached to an object, for the purposes of automatic identification and tracking. Some tags require no battery and are powered by the radio waves used to read them. Others use a local power source. The tag contains electronically stored information which can be read from up to several metres (yards) away. Unlike a bar code, the tag does not need to be within line of sight of the reader and may be embedded in the tracked object.

Since RFID tags can be attached to clothing, possessions, or even implanted within people, the possibility of reading personally-linked information without consent has raised privacy concerns.

Now, French researchers have developed a means of making RFID tags even easier to attach and could further increase privacy concerns. From the Feb. 6, 2012 news item on Nanowerk,

Radio Frequency Identification (RFID) tags are an essential component of modern shopping, logistics, warehouse, and stock control for toll roads, casino chips and much more. They provide a simple way to track the item to which the tag is attached. Now, researchers in France have developed a way to deposit a thin aluminum RFID tag on to paper that not only reduces the amount of metal needed for the tag, and so the cost, but could open up RFID tagging to many more systems, even allowing a single printed sheet or flyer to be tagged …

The researchers used this technique,

There are several techniques used to deposit an antenna on PET: etching, electroplating; and on paper: screen printing, flexography and offset lithography. Now, Camille Ramade and colleagues at the University of Montpellier have demonstrated how a simple thermal evaporation process can deposit an aluminum coil antenna on to paper for use as an RFID tag. Aluminum is a lot less expensive than copper or silver, which are used in some types of RFID tag. The researchers suggest that the approach would reduce the cost of RFID tagging to a fifth of current prices, which could represent significant savings for inventory users operating millions of RFID tags in their systems.

For anyone who’s curious about PET, it’s a plastic substrate. From the NAPCOR website page about PET,

PET stands for polyethylene terephthalate, a plastic resin and a form of polyester.