Tag Archives: Peter Julian

Canada’s consultation on nanoscale forms of substances on the Domestic Substances List (DSL)

Yes, there’s a redundancy in the head but there doesn’t seem to be a way around it. Ah well, it seems about seven weeks after Peter Julian (Member of Parliament) introduced his bill in the Canadian House of Commons to regulate nanotechnology (Aug. 29, 2016 posting), Environment and Climate Change Canada (ECCC) and Health Canada (HC) have announced a consultation on nanoscale materials. From an Aug. 4, 2016 posting by Lynn L. Bergeson on Nanotechnology Now (Note: Links have been removed),

On July 27, 2016, Environment and Climate Change Canada (ECCC) and Health Canada (HC) began a consultation on a proposed prioritization approach for nanoscale forms of substances on the Domestic Substances List (DSL). See http://www.ec.gc.ca/lcpe-cepa/default.asp?lang=En&n=FA3C8DBF-1 Canada will use the proposed approach to: (1) establish a list of existing nanomaterials in Canada for prioritization; (2) identify how the information available will be used to inform prioritization of nanomaterials for risk assessment; and (3) outline the proposed outcomes of the prioritization process. In 2015, Canada conducted a mandatory survey under Section 71 of the Canadian Environmental Protection Act, 1999 (CEPA). The survey applied to persons who manufactured or imported any of 206 nanomaterials at a quantity greater than 100 kilograms (kg) during the 2014 calendar year. See http://www.ec.gc.ca/ese-ees/default.asp?lang=En&n=28ABBAC9-1%20-%20s1 Based on the results of the survey, ECCC and HC will prepare a final list of confirmed existing nanomaterials in Canada and will use the list for subsequent prioritization. ECCC and HC propose that, where possible, the substances identified via the survey be “rolled up into” their broader parent nanomaterial groups for the purposes of prioritization. According to ECCC and HC, this will allow, when possible, a more robust look at the hazard, volume, and use data as appropriate, rather than considering an individual substance-by-substance approach. ECCC and HC state that further consideration for sub-grouping (such as by use, unique property, or functionalization) may need to be considered for prioritization and/or risk assessment. …

You can find the Government of Canada’s 2015 Consultation Document: Proposed Approach to Address Nanoscale Forms of Substances on the Domestic Substances List page here, which set the stage for this prioritization exercise.

You can also find the Proposed prioritization approach for nanoscale forms of substances on the Domestic substances list page here where you’ll find information such as this,

Possible nanomaterial groupings, based on parent substance

Aluminum oxide
Iron (II)/(II/III) oxide
Modified silica
Bismuth oxide
Magnesium oxide
Silicon oxide
Calcium carbonate
Manganese (II & III) oxide
Silver
Cerium oxide
Nanocellulose
Titanium dioxide
Cobalt (II) oxide
Nanoclays
Yttrium oxide
Copper (II) oxide
Nickel (II) oxide
Zinc oxide
Gold
Quantum dots
Zirconium oxide

You can also find information on how to submit comments,

Stakeholders are invited to submit comments on the content of this consultation document and provide other information that would help inform decision making. Please submit comments to one of the addresses provided below by September 25, 2016 [emphasis mine]. ECCC and HC will respond to comments and adapt the proposed approach based on the feedback received on this document, as described in Section 1.2.

Comments on this consultation document can be submitted to one of the following addresses:

By Mail:
Environment and Climate Change Canada
Substances Management Information Line
Chemicals Management Plan
351 St. Joseph Boulevard
Gatineau, Québec
K1A 0H3

By Email:
eccc.substances.eccc@canada.ca
Please type “Consultation on Prioritization Approach for Nanomaterials” in the subject line of your message.

By Fax:
819-938-5212

Suddenly, there’s lots (relative to the last few years) of action on nanotechnology regulation in Canada.

Everything old is new again: Canadian Parliament holds first reading of another bill to regulate nanotechnlogy

Back in March 2010, Canadian New Democratic Party (NDP) Member of Parliament (MP) Peter Julian introduced a bill to regulate nanotechnology (Bill C-494) in Canada. The Conservative government was in power at the time. I can’t remember how many readings it received but it never did get passed into legislation. Now, Mr. Julian is trying again and, coincidentally or not, the Liberals are in power this time. A July 26, 2016 post by Lynn L. Bergeson and Carla N. Hutton for the National Law Review (Note: Links have been removed),

On June 8, 2016, the Canadian House of Commons held its first reading of an Act to amend the Canadian Environmental Protection Act, 1999 (CEPA) (nanotechnology) (C-287).  The bill would add Part 6.1 to CEPA primarily to implement procedures for the investigation and assessment of nanomaterials. …

The bill would define nanomaterial as any manufactured substance or product or any component material, ingredient, device or structure that:  (a) is within the nanoscale (one nanometer (nm) up to and including 100 nm), in at least one external dimension; or (b) if it is not within the nanoscale, exhibits one or more properties that are attributable to the size of a substance and size effects.  The bill mandates a risk assessment process to identify the potential benefits and possible risks of nanotechnologies before nanoproducts enter the market.  It would also create a national inventory regarding nanotechnology, including nanomaterials and nanoparticles, using information collected under CEPA Sections 46 and 71 and “any other information to which the Ministers have access.” On July 25, 2015, Canada published a notice announcing a mandatory survey under CEPA Section 71(1)(b) with respect to certain nanomaterials in Canadian commerce.  …

I do have a few observations about the proposed bill. First, it’s more specific than what we have in place now. As I understand current CEPA regulations, they do not cover materials at the nanoscale which are already imported and/or produced at the macroscale and are considered safe, e.g. titanium dioxide. It is assumed that if they’re safe at the macroscale, they will be safe at the nanoscale. I gather this bill is designed to change that status.

Second, there is no mention in Julian’s press release (text to follow) of the joint Canada-United States Regulatory Cooperation Council (RCC) Nanotechnology Initiative which was designed to harmonize US and Canadian regulatory approaches to nanotechnology. Would bill C-287 introduce less harmony or was it designed to harmonize our approaches?

Third, I don’t see a big problem with the idea of an inventory, the issue is always implementation.

Finally, it appears that this bill means more bureaucrats or computerized systems and I’m not sure it addresses the problem that I believe it is trying to address: how to deal with uncertainty about the risks and hazards of an emerging technology while meeting demands for economic progress.

Very finally, here’s Peter Julian’s June 8, 2016 press release,

Julian’s bill to include Nanotechnology under Environmental Protection Act

You can watch the video here: https://peterjulian.ca/Introduction_of_Private_Member_Bill_C287_An_Act_t…

OTTAWA – Today [June 8, 2016], Peter Julian, MP (New Westminster-Burnaby) re-introduced Bill C-287 in the House of Commons, which aims to include a framework that would regulate nanotechnology in the Canadian Environmental Protection Act.

“I first introduced this Bill in 2010. I am pleased to see that some of the aspects of this Bill are being considered by Health Canada and Environment Canada, such as the development of a registry for nanomaterials in commerce and use in Canada. However, there is much more that needs to be done to ensure the responsible use of nanotechnologies in Canada”, said Julian.

Nanotechnology is the application of science and technology to manipulate matter at the atomic or molecular level. Nanomaterials are any ingredient, device, or structure that is between 1 and 100 nm. These materials are present in more than 1000 consumer products, including food and cosmetics. The increasing proliferation of nanoproducts has not been met with an adequate regulatory framework.

Julian’s Bill C-287 would establish a balanced approach ensuring the responsible development of nanotechnology and the safe use off nanomaterials in Canada. The Bill mandates a risk assessment process to identify the potential benefits and possible risks of nanotechnologies before nanoproducts enter the market. It would also require a comprehensive, publicly accessible database that lists existing nanomaterials identified by the Government of Canada.

“While nanotechnology can be very beneficial to people, there are certain risks to it as well. We must identify and mitigate possible risks to better protect the environment and human health before they become an issue. Canada must ensure our regulatory processes ensure nanomaterial safety before the introduction of these substances in Canada”, said Julian.

I’m including links to my 2010 email interview with Peter Julian (published in three parts),

March 24, 2010 (Part one)

March 25, 2010 (Part two)

March 26, 2010 (Part three)

I also covered a hearing on nanomaterials and safety held by the Canadian House of Commons Standing Committee on Health on June 10, 2010 in a June 23, 2010 posting.

4th assessment of the US’s National Nanotechnology Initiative (found some info. about Canada in the rept.!)

It seems there a number of reports concerning the US National Nanotechnology Initiative and their efforts and responses to the PCAST 2010 recommendations (I commented on another of their reports in my Dec. 13, 2011 posting). This fourth report/assessment was submitted by the President’s Council of Advisors on Science and Technology (PCAST) and focuses on efforts from various government agencies to follow recommendations from that 2010 PCAST assessment and set of recommendations.

According to the April 27, 2012 news item on Nanowerk,

PCAST found that the Federal agencies in the NNI have made substantial progress in addressing many of the 2010 recommendations that were aimed at maintaining U.S. leadership in nanotechnology. One of the primary goals of the NNI is to stay ahead of heavily-investing competitors such as China, South Korea, the European Union, and Russia. Overall, PCAST concluded that the NNI remains a successful cooperative venture that is supporting high-quality research, facilitating the translation of discoveries into new commercial products, and ensuring the Nation’s continued global leadership in this important field.

The PCAST assessment particularly commends the expanded efforts of the NNCO [National Nanotechnology Coordination Office] in the area of commercialization and coordination with industry, and the NNCO’s release of a focused research strategy for addressing environmental, health, and safety (EHS) implications of nanotechnology. In addition, the assessment recognizes NNI’s strong and growing portfolio of research on the societal implications of nanotechnology, nanotechnology education, and public outreach.

Dexter Johnson at his Nanoclast blog on the IEEE (Institute of Electrical and Electronics Engineers) website comments in his May 1, 2012 posting,

Okay, pat on the back, job well done…uh, wait, there are still some new recommendations that PCAST would like to see addressed.  You can find them in the PDF of the full report on page vii. They fall into the areas of strategic planning, program management, metrics for assessing nanotechnology’s commercial and societal impacts, and…wait for it…increased support for EHS research.

Additional support for EHS research might be a required element for every PCAST report in the future. More interesting to me, however, is this continued emphasis on improved “metrics for assessing nanotechnology’s commercial and societal impacts.”

Dexter goes on to observe that many countries and corporations are interested in better metrics regarding  nanotechnology and its impacts and hints that he has a few ideas for better metrics.

I’ve looked at the report and found, to my surprise, mention of Canada. In analyzing the US NNI efforts, they also compare US government funding and corporate to that in other countries. On page 14 (print version; p. 30 PDF) of the PCAST 4th Assessment of the NNI, there’s a table which shows the top 10 countries for spending on nanotechnology,

As you can see, Canadian funding has been relatively flat throughout 2008 – 2010. It appears to have decreased slightly in 2009 and remained the same in 2010.

Aside: I’d dearly love to know how they sourced their data. A couple of years ago, a Canadian Member of Parliament (Peter Julian) asked for similar figures and received some 80 pages of Excel spreadsheets from various department listing any number of research projects that had been funded. (I’d asked Julian’s parliamentary assistant for a copy of the government’s response to his question, which is how I came to see that mess of paper.)

For anyone familiar with the Canadian scene (industrial research in Canada is rare), this next chart won’t be any surprise, from page 14 (print version; p. 30 PDF) of the PCAST 4th Assessment of the NNI,

However, this may be a surprise, from page 15 (print version; p. 31 PDF) of the PCAST 4th Assessment of the NNI,

Good grief! Canada is in the top five countries for venture capital spending on nanotechnology. Of course, we had our banner year in 2008, with quite a dip in 2009 but it looks like we rebounded mildly in 2010.

It’s always interesting for me to analyze the US nanotechnology efforts in relationship to the Canadian efforts (as well as, getting a sense of the international scene). Actually, I can’t analyze our efforts since the Canadian government doesn’t tend to share information (or provides reams of meaningless data) with its citizens so I’m driven to finding it in US government documents and materials provided by international governmental organizations such as the OECD (Organization for Econ0mic Cooperation and Development).

Getting back to the report, which after all is about the US situation, I’m particularly interested in the recommendations for metrics (thank you, Dexter) and EHS. From page 22 (print version; p. 38 PDF) of the PCAST 4th Assessment of the NNI (I have edited out some footnotes),

Agencies should develop a mission-appropriate definition of nanotechnology that enables the tracking of specific nanotechnology investments supported at the program level. The definition and funding details should be published in agency implementation plans to promote clarity.

This recommendation enables each agency to develop a mission-appropriate definition of nanotechnol­ogy to characterize its nanotechnology portfolio. Requiring each agency to publish its definition and the resulting budget allocations will improve clarity across the Federal nanotechnology portfolio and ensure that nanotechnology investments are accurately characterized.

The NNCO should track the development of metrics for quantifying the Federal nanotechnology portfolio and implement them to assess NNI outputs.

Current Federal efforts to measure public and private investment, scientific productivity, and workforce have been inconsistent and decentralized. The publication of agency-specific data will enable the NNCO to consistently track nanotechnology investments across the Federal government and enable it to report NNI impacts with greater confidence and transparency.

There is an extensive and growing body of high-quality academic research that is already working toward the establishment of nanotechnology metrics by drawing upon bibliometrics data from the public domain (e.g., publication and patent data). … Bibliometrics data are used as indicators of productivity beyond academia, often in the absence of other metrics from the private sector. As nanotechnology continues to mature and move closer toward commercialization, efforts to more accurately capture economic returns are picking up pace. Examples include the March 2012 International Symposium on Assessing Economic Impacts of Nanotechnologies sponsored jointly by the NNI and the Organization for Economic Co-Operation and Development held in Washington, DC, [mentioned in my March 29, 2012 posting] as well as the upcoming 2012 National Research Council review of the NNI.

A final area in need of metrics development is in the quantification of the nanotechnology workforce.  [emphasis mine] Accurately categorizing agency-level nanotechnology investments will facilitate the identification of nanotechnology trainees, including the academic, scientific, and professional nanotechnology workforce for which there is currently a paucity of data…. One area where such tracking would have significant impact is in the identification of nanotechnology-related jobs for which there are no standard occu­pational codes. Good data on the workforce will enable the implementation of additional measures to identify and mitigate future threats to occupational health and safety.

PCAST recommends that NNCO serve as a central repository to collect these metrics and leverage advances in metrics-development to collect, track, and analyze data regarding publications, patents, educational activities, and the workforce to produce and publish its own statistics on behalf of the NSET. This under­taking is an integral component of cross-agency coordination of the Federal nanotechnology portfolio.

That first recommendation seems problematic. The notion of agencies developing mission-specific definitions of nanotechnology, as recommended, sets the stage for multiple and competing definitions in a situation where you want to standardize as much as possible.

Unfortunately, the alternative is not an improvement. An attempt to standardize across all agencies would most probably lead to years of meetings and discussions before anything was ever measured.

I’m not quite as confident about bibliometrics as the authors of this report are but, as they hint, oftentimes it’s the only quantifiable data available. While there is much talk about establishing other metrics, there is no hint as to how this will be done or who will do it or whether money will be allocated for this purpose.

The recommendations for further EHS research, from pp. 22-3 (print version; pp. 38-9 PDF) of the PCAST 4th Assessment of the NNI, include (I have edited out a reference to an appendix),

The NSET should establish high-level, cross-agency authoritative and accountable governance of Federal nanotechnology-related EHS research so that the knowledge created as a result of Federal investments can better inform policy makers.

PCAST acknowledges that the NSET has acted on our recommendation to identify a central coordina­tor for nanotechnology-related EHS research within NNCO. The EHS coordinator has done a laudable job developing and communicating the 2011 NNI EHS research strategy. However, there is still a lack of integration between nanotechnology-related EHS research funded through the NNI and the kind of information policy makers need to effectively manage potential risks from nanomaterials. The estab­lishment of the Emerging Technologies Interagency Policy Coordination Committee (ETIPC) through OSTP has begun to bridge that gap, but without close integration between ETIPC and the NEHI working group, the gap may not be sufficiently narrowed. OSTP and the NSET Subcommittee should expand the charter of the NEHI working group to enable the group to address cross-agency nanotechnology-related policy issues more broadly.

The NSET should increase investment in cross-cutting areas of EHS that promote knowledge transfer such as informatics, partnerships, and instrumentation development.

The 2011 NNI EHS research strategy acknowledges the critical role that informatics, partnerships, and instrumentation development play in a comprehensive approach to addressing nanotechnology risks to human health and the environment. Nascent efforts in informatics should be supported so that advances can be accelerated in this critical cross-cutting area. Rather than continue to support the proliferation of databases that results from many new nano-EHS projects, the effort should be directed at enabling diverse communities to extract meaningful information from each other’s work. New networks that connect researchers together, along with new tools for extracting information from Federally funded research, should be established and supported through the NNI. The findings of the December 2011 workshop to establish a Nanoinformatics 2020 Roadmap19 in conjunction with the 2011 NNI EHS research strategy can serve as a guide for new work in this area.

Significant progress has been made in the area of partnerships with numerous examples of mul­tistakeholder and interagency collaboration underway. One of these is the Nanorelease Project,20 which brings together five NNI agencies, non-governmental organizations, a labor union, and several companies, among others, to develop methods for measuring the release of nanomaterials from com­mercial products. A specific area where better coordination could occur is in the area of occupational safety. The Occupational Safety and Health Administration (OSHA) should work with companies in a non-enforcement capacity to develop better tools for hazard communication similar to the National Institute of Occupational Health and Safety’s (NIOSH) partnership program. This is especially important as the United States seeks to bring its hazard communication standard in alignment with the Globally Harmonized System of Classification and Labeling of Chemicals. Greater engagement by OSHA would also begin to address some of the difficulties companies face in implementing good health and safety programs in their nanomaterial workplaces …

New modes of international cooperation, such as the joint funding of two environmental-impacts consortia by the EPA and the United Kingdom, have also emerged since the 2010 PCAST report. The NNI should increase funding for these cross-cutting activities to leverage the U.S. investment in nanotechnology-related EHS research.

The wealth of abbreviations makes this section a little hard to read. As I understand it, the recommendations are aimed at improving use of their current and future resources by better coordinating the research efforts, sharing data (with a special eye to providing information policymakers can use effectively), and collaborating internationally on EHS research.

Quebec’s new report on the risks of engineered nanoparticles

Engineered Nanoparticles; Current Knowledge about OHS [Occupational Health and Safety] Risks and Prevention Measures is the title for a report (2nd edition) written by Claude Ostiguy, Brigitte Roberge, Catherine Woods, and Brigitte Soucy for the Quebec-based Institut de recherche Robert-Sauvé en santé et en sécurité du travail (IRSST). From the news item on Nanowerk,

An initial assessment of the state of scientific knowledge about the occupational health and safety aspects (OHS) related to synthetic nanoparticles (NP) was published by the IRSST in 2006 and covered the scientific literature until the end of 2004. What was found was that OHS knowledge was very fragmentary but that research in this field was rapidly growing. This current document aims to assess the state of current knowledge in this field and summarizes the data available until early 2010.

Overall, what emerges is that NP remain an important source of concern in OHS. In fact, not only does the diversity of commercially available chemical products of nanometric dimensions continue to increase, but also, the information available about the hazards specific to these substances is still very fragmentary. The literature gives us very little information specific to NP relating to their physical hazards like fires or explosions.

In a context of incomplete data for the majority of nanometric substances, it remains impossible to quantify the risks for workers in the majority of situations because the toxicity of the products, the level of dust contamination of workplaces, or their potential to cause fires or explosions remain not extensively documented or totally undocumented. Nevertheless, the majority of the means of exposure control for ultrafine particles should be effective against NP and much research is currently being carried out to confirm this.

In a context of uncertainty about the risks, and with an increasing number of potentially exposed workers, the current report paints a big picture of the OHS knowledge currently available in the NP field. In the absence of specific standards, a preventive and even a precautionary approach are recommended, and a review of the available means for minimizing worker exposure is presented.

The report (over 150 pp.) can be found here. There’s certainly much to appreciate in the report. Here are two bits that I particularly want to highlight, the acknowledgment that nanoparticles aren’t new,

Although the development of NT [nanotechnology] is a modern multidisciplinary science, naturally produced and manmade materials of nanometric dimensions and exposure to particles of other dimensions of mineral or environmental origin, including the fine fraction of nanometric particles, have always existed. Some of the natural nanometric particles are of biological origin – including DNA with a diameter of around 2.5 nm and many viruses (10 to 60 nm) and bacteria (30 nm to 10 μm) — while others are found in desert sand, oil fumes, smog, and fumes originating from volcanic activity or forest fires and certain atmospheric dusts. Among those generated by human activity, we should mention diesel fumes, industrial blast furnace emissions and welding fumes, which contain particles of nanometric dimensions (Teague, 2004). (p. 11 PDF, p. 1, print)

There’s also a very good (in my opinion) description of bottom-up and top-down approaches to engineered nanoparticles,

Nanoparticles can be synthesized by different approaches. Nanoparticle production can be generally categorized into the bottom-up and top-down methods. In the bottom-up approach, nanoparticles are constructed atom-by-atom or molecule-by-molecule. In the top-down approach (top-down), a large structure is gradually underdimensioned, until nanometric dimensions are attained after application of severe mechanical stresses, violent shocks and strong deformations. The two approaches bottom-up and top-down tend to converge in terms of dimensions of the synthesized particles. The bottom-up approach seems richer, in that it allows production of a greater diversity of architectures and often better control of the nanometric state (relatively monodispersed granulometric sizes and distribution, positioning of the molecules, homogeneity of the products). The top-down approach, although capable of higher-volume production, generally makes control of the nanometric state a more delicate operation. (p. 25 PDF, p. 15 print)

Ostiguy (last mentioned in my June 23, 2010 posting [Nanomaterials, toxicity, and Canada’s House of Commons Standing Committee on Health] as an expert witness) and his colleagues offer a good overview of  international, national, and provincial (Québec) research and development efforts including definitions for terms and descriptions of various types of nanoparticles and a discussion about markets. I was expecting something more narrowly focused on occupational health and safety (OHS) but very much appreciate the efforts to contextualize OHS issues within the larger nanotechnology ‘enterprise’ in addition to the OHS material.

Oddly, I found this on the cover page,

Disclaimer

The IRSST makes no guarantee regarding the accuracy, reliability or completeness of the information contained in this document. In no case shall the IRSST be held responsible for any physical or psychological injury [??? and emphasis mine] or material damage resulting from the use of this information.

Note that the content of the documents is protected by Canadian intellectual property legislation.

As for any psychological injury I may received from reading the report, what about injury from reading the disclaimer?

I do have a few nits to pick. Surprisingly since this report was published in July 2010, they did not include any information about an April 2010 nanomaterial definition proposed in the US (my April 27, 2010 posting). More picayune, reference is made to Nanotech BC which has been effectively defunct since Spring 2009 while no mention is made of Nano Ontario which I first noticed in early 2010 (Professor Gilbert Walker responded on behalf of Nano Ontario to Peter Julian’s proposed nanotechnology legislation in my March 29, 2010 posting).

I was also surprised at the certainty expressed about scientific unanimity over the dimensions,

As already mentioned, there is now unanimity in the scientific community on the dimensions of manufactured NP: at least one of their dimensions ranges between one and 100 nm [emphasis mine] and they have different properties than larger-diameter particles made of the same material (ASTM, 2006; BSI, 2008; ISO, 2007, 2008). (p. 49 PDF, p. 39 print)

As I understand it, there’s still some discussion about the one to one hundred nanometre range as I note here in my July 14, 2010 posting,

The comment about the definition sprang out as this issue seems to be at the forefront of many recent discussions on nanotechnology. Fern Wickson and her colleagues highlight the importance of the issue in their recently published paper,

Both the beginning and the end of this range remain subject to debate. Some claim that it should extend as low as 0.1nm (because atoms and some molecules are smaller than 1nm) and as high as 300nm (because the unique properties of the nanoscale can also be observed above 100nm). The boundaries of ‘the nanoscale’ are highly significant in both scientific and political terms because they have the possibility to affect everything from funding, to risk assessment and product labelling. [my commentary, Wickson’s response, and a citation for the paper, etc. can be found in my July 7, 2010 posting]

I do recommend reading the IRSST report if this sort of thing interests you as it offers answers to questions that you may (and, in my case, certainly) have been asking yourself about quantum dots, carbon black, and the state of OHS research and regulations in Canada and elsewhere.

Nanocrystalline cellulose interview with Dr. Richard Berry of FPInnovations

Nanocrystalline cellulose (NCC) is one of the most searched items on this blog so it seemed like a good idea to send some questions about it to a Canadian company, FPInnovations, that has been a leader in  its development.  [Edited for typo, July 7, 2011] Dr. Richard Berry, program manager for FPInnovations very kindly answered. First a little biographical information,

Dr. Richard Berry is the manager of the FPInnovations Chemical Pulping Program and he has been the leader of the nanotechnology initiative at FPInnovations for the last several years. Dr. Berry is a key contributor to ArboraNano. His scientific accomplishments include work on the elimination of chlorinated dioxins and the development of a variety of bleaching technologies. Dr. Berry has overseen the industrial application of his numerous inventions. He is the author of more than eighty peer-reviewed publications and patents. The prestigious 2009 Nano-industry award from NanoQuébec was given to him for his exceptional contribution to the development of Nanocrystalline Cellulose. The initiatives Dr. Berry has spearheaded in recent years have allowed Canada to position itself as a world leader in the development of this new nanotechnology industry.

Now for the  interview:

Q: In light of the new Domtar-FPInnovations plant [mentioned here in my July 16, 2010 posting] which is going to be built in Windsor, Québec, could you tell me a little about nanocrystalline cellulose (NCC). I have looked at your information sheet which notes that cellulose is: milled then hydrolyzed with the NCC separated and concentrated so it can be treated chemically for new uses.  In layperson’s terms, what’s cellulose?

A:         Cellulose is the most abundant polymer on earth and is the major constituent of all plants; cotton is 100% cellulose. Cellulose is made of chains of glucose molecules and these arrange into amorphous (soft) and crystalline (hard) regions. These structures provide flexibility and strength respectively to the fibres that are made of cellulose.

The hard crystalline regions are separated from the soft amorphous regions in the process that we are using which also causes the separation of the crystallites in the crystalline regions. These crystallites are nanocrystalline cellulose and have a needle shape approximately 200nm in length and 10 nm in diameter

Q: What does hydrolyze mean, in simple terms?

A:         Hydrolyze in this process means that we break the bonds between the glucose molecules. This reaction occurs far more rapidly in the soft amorphous regions of the cellulose structure leaving the hard crystalline regions largely intact

Q: After [Edited for grammar, July 7, 2011] all this processing, do you have nanocrystalline cellulose and how would you describe what nanocrystalline cellulose is?

A:         The process is to produce nanocrystalline cellulose but many of the processing steps are to ensure that the process is closed cycle and that the acid used is recovered and that the dissolved glucose can be separated to make energy, ethanol or higher value chemical products.

Nanocrystalline cellulose is the basic physical building block of plants which therefore have used nanotechnology for eons. The crystallites are the reinforcement elements providing strength in wood, paper and fibres.

Q: Does the process use up the entire log or are parts of it left over? What happens to any leftover bits?

A:         We are starting from the bleached chemical pulp which is, to a large extent, cellulose. The left over bits have actually been processed as part of the chemical pulp mill processes. The acid used is recovered and reused and the sugars are converted into other products; in the demonstration plant they will be converted into biogas.

Q: I understand you won’t want to give away any competitive advantages but could you describe at least partially the sort of chemical processing involved for these new applications?

A:         In some applications, there is no processing needed at all. In other applications, the formulation used allows the NCC to be effective. In further applications, surface modification is required to maximize the properties.

Q: Is the new plant (Domtar-FPInnovations) meant to be used for producing nanocrystalline cellulose particles for shipment elsewhere? Or will there be work on applications using the nanoparticles? If so, on which application(s) are you concentrating your efforts?

A:         The plant presently is for producing various grades of nanocrystalline cellulose for shipment elsewhere. The applications are being developed with partners in the new industry sectors that we are targeting. Amongst others, we have partners for applications in coatings, films and textiles.

Q: Is FPInnovations involved with the ArboraNano Centre of Excellence programme and its efforts to encourage NCC use in industries not usually associated with forest products? What might involvement entail?

A:         FPInnovations is one of the founding members and had a significant role in setting up ArboraNano.  Our involvement presently is as a supplier of NCC through our pilot plant in Pointe Claire and as members of both the Scientific Committee and Board of Arboranano.

Q: Assuming FPInnovations is attending the 2010 TAPPI [International Conference on Nanotechnology for the Forest Product Industry] in Finland, can you give me a preview of the company’s proposed presentation(s) at the conference?

A:         Representatives of FPInnovations will be at the conference but our involvement will be limited because much of the material we have developed is proprietary to ourselves and to the partners that we have. Our focus at this stage is commercial development.

Q: What kind of research is being done on possible health, safety and environment issues with regard to NCC?

A:         From the very beginning of our project, 20% of our funding has been spent on these issues. We are glad to say that the research has shown that NCC is in the category of “practically non toxic”, and mammalian studies done to assess inhalation, ingestion and dermal risk have all shown the material to be in the lowest category of risk. These results show that the size of a particle is not a determinant of its risk but as with chemicals it is the specific material that is critical in determining toxicity.

Q: Are there plans, at some point in the future, to list NCC on Charles McGovern’s Integrated Nano-Science Commodities Exchange or will your product be listed on some other commodities exchange?

A:         We do not view NCC at the moment as a commodity; it is a very specialized group of materials. We hope it will take a long time before it becomes a commodity.

Thank you very much Dr. Berry.

On a related matter, I was fortunate enough to receive a copy of the documentation that the Canadian federal government provided in response to Member of Parliament, Peter Julian’s (NDP), question about nanotechnology funding from 2005/6 – 2008/9. The response from Natural Resources Canada highlighted funding provided to FPInnovations in fiscal year 2007/8 of $2,308,000 and in fiscal year 2008/9,  a further, $3,2570,000 for a total of $5,565,000. Natural Resources Canada did not fund any nanotechnology research in 2005/6 or 2006/7.

One final note, former president and chief executive officer of FPInnovations, Ian de la Roche, PhD, will be the keynote speaker at the 10th Pacific Rim Bio-Based Composites Symposium Oct. 5-8, 2010 in Banff, Alberta. (Thanks to Joel Burford at Alberta Innovates Technology Futures for the information.)

A tale of two countries and nanotechnology strategies (part 2 of an occasional series)

The US National Nanotechnology Initiative’s (NNI) tenth anniversary celebration titled, Nanotechnology Innovation Summit was announced about a week ago around the same time I received a copy of the documentation outlining the Canadian government’s expenditures on nanotechnology from the fiscal years 2005/6 to 2008/9.

The documentation which was issued in response to a question by Member of Parliament Peter Julian is some 80 pages that’s not organized in a way that makes for easy reading. (I interviewed Peter Julian, New Democratic Party, about his private member’s bill on nanotechnology here in part 1, part 2, and part 3.) Since there is no single nanotechnology funding hub, each ministry or funding agency issues its own records which is usually in the form of spreadsheets and each agency has its own organizing strategy. It’s going to take a little more time before I can make much sense of it but once I do, I’ll try to post it here.

Meanwhile, I found this July 26, 2010 news item about the NNI’s 10 anniversary on Nanowerk,

The Nano Science and Technology Institute (NSTI), in cooperation with the Office of Science and Technology Policy (OSTP) and the National Nanotechnology Coordination Office (NNCO), announced today a National Nanotechnology Innovation Summit to mark the 10th anniversary of the National Nanotechnology Initiative (NNI) to be held December 8-10, 2010 at the Gaylord National Hotel & Convention Center in National Harbor, MD. The event, in cooperation with OSTP and NNCO and organized by NSTI, with key support from the National Venture Capital Association (NVCA), will serve as a forum for the nation’s nanotechnology innovators, investors, policy makers and leading corporate developers and integrators.

Since its formal launch in 2001 under President Clinton, the National Nanotechnology Initiative has strategically invested and coordinated over $12 billion in nanotechnology development. [emphasis mine] The NNI Nanotechnology Innovation Summit will spotlight revolutionary technologies from the 10-year NNI funding effort, with a special emphasis on showcasing commercially transformational technologies directly funded or catalyzed by the multi-agency partnership of the NNI. Participants will hear from some of the top researchers, industry leaders, technology investors and visionary policy makers of our time as they speak about the impact of nanotechnology innovation over the past 10 years and look toward the future.

Intriguing, yes? In the US, they can state they’ve spent 12B US over 10 years (I assume they can break those figures down) while in Canada, the figures don’t appear to have been aggregated even on agency by agency basis.

I think it comes down to a basic philosophical difference in how nanotechnology has been approached. In the US (and many other juridictions) it’s been treated as a specialty in and of itself. The approach makes sense since chemistry at the nanoscale is significantly different from chemistry at the macroscale.

In Canada, we seem to have taken the perspective that nanotechnology is a continuation of scientific exploration and while the particulars differ dramatically, nanotechnology itself is a logical progression of the scientific enterprise.

I don’t know that one approach is better than the other but the US approach makes funding questions a lot easier to answer.

Nanomaterials, toxicity, and Canada’s House of Commons Standing Committee on Health

Thanks to a reader who provided me with a link, I found a document (titled Evidence) about a ‘nanomaterials’ hearing held by Canada’s House of Commons Standing Committee on Health on June 10, 2010 and chaired by Joyce Murray, Member of Parliament, Vancouver Quadra. It makes for interesting reading and you can find it here.

The official title for the hearing was Potential Risks and Benefits of Nanotechnology, which I found out after much digging around. The purpose for the *hearing*  seemed to be the education of the committee members about nanotechnology both generally (what is it? is there anything good about it?) and about its possible toxicology.

For information about the committee and the meeting, go here to find the minutes, the evidence (direct link provided in 1st para.), and your choice of webcasts (English version, French version, and floor version). One comment before you go, keep scrolling down past the sidebar and the giant white box to find the list of meetings along with appropriate links and if you choose to listen to the webcast, wait at least 1 minute for the audio to start. There’s a list of the committee members here, again scroll down past the giant white box to find the information.

I am going to make a few comments about this hearing. I will have to confine myself to a few points as the committee covered quite a bit of ground in the proceedings as they grappled with understanding something about nanotechnology, health and safety issues, benefits, and regulatory frameworks, amongst other issues.

It was unexpected to find that Mihail Roco, a well known figure in the US nanotechnology field, was speaking via videoconference (from the document),

Dr. Mihail Roco (Senior Advisor for Nanotechnology, National Nanotechnology Initiative, National Science Foundation, As an Individual) (p. 1 in print version, p. 3 in PDF)

He did have this to say,

First of all, I would like to present an overview of different themes in the United States, and thereafter make some recommendations, some ideas for the future. [emphasis mine] (p. 5 in print version, p. 7 in PDF)

I have to say my eyebrows raised at Roco’s “… make some recommendations …” comment. While appreciative of his experience and perspective, I’ve sometimes found that speakers from the US tend to give recommendations that are better geared to their own situation and less so to the Canadian one. Thankfully,  he offered unexceptional advice that I heartily agree with,

I would like to say, in conclusion, that it’s important to have an anticipatory, participatory, and adaptive governance approach to nanotechnology in order to capture the new developments and also to prepare people, tools, and organizations for the future. (p. 6 in print version, p. 8 in PDF)

The Canadian guests are not as well known to me save for Dr. Nils Petersen who heads up Canada’s National Institute of Nanotechnology. Here is a list of the Canadian guest speakers,

Mr. (sometimes referred to as Dr. in the document) Claude Ostiguy (Director, Research and Expertise Support Department, Institut de recherche Robert-Sauvé en santé et en sécurité du travail) (p. 1 in print version, p. 3 in PDF)

Dr. Nils Petersen (Director General, National Research Council Canada, National Institute for Nanotechnology) (p. 2 in print version, p. 4 in PDF)

Dr. Claude Emond (Toxicologist, Department of Environmental and Occupational Health, Université de Montréal) (p. 3 in print version, p. 5 in PDF)

Ms. Françoise Maniet (Lecturer and Research Agent, Centre de recherche interdisciplinaire sur la biologie, la santé, la société et l’environnement (CINBIOSE) et Groupe de recherche en droit international et comparé de la consommation (GREDICC), Université du Québec à Montréal) (p. 4 in print version, p. 6 in PDF)

Emond spoke to the need for a national nanotechnology development strategy. He also mentioned communication although I’m not sure he and would agree much beyond the point that some communication programmes are necessary,

The different meetings I attend point out the necessity to integrate the social communication transparency education aspect in nanotechnology development, so many structures already exist around the words. As I said before with OECD, NNI, we also have ISO 229. Now we have a network called NE3LS in Quebec, and we also have this international team we created a few years ago, which I spoke about earlier [he leads an international team in nano safety with members from France, Japan, US, Germany, and Canada].

A Canadian strategy initiative in nanotechnology can be inspired by a group above. In closing the discussion, I want to say there is an urgent need to coordinate the national development of nanotechnology and more particularly in parallel with the nanosafety issue, including research, characterization exposure, toxicology, and assessment. I would like to conclude by saying that Canada has to assume leadership in nanosafety and contribute to this international community rather than wait and see.

The NE3LS in Québec is new to me and I wonder if  they liaise with the team in Alberta last mentioned here in connection with Alberta’s Nanotechnology Asset Map.

In response to a question from the committee member, Mrs. Cathy McLeod, Kamloops—Thompson—Cariboo,

First, because I am someone who is somewhat new to the understanding of this issue, could we take an example of either a cosmetic or a food or something that’s commonplace and follow it through from development into the product so I could understand the pathway of a nanoparticle in a cosmetic product or food? (p. 6 in print version, p. 8 in PDF)

The example Dr. Ostiguy used for his response was titanium dioxide nanoparticles in sunscreens and his focus was occupational safety, i.e., what happens to people working to produce these sunscreens.  The surprising moment came when I saw Dr. Petersen’s response as he added,

In the case of cosmetics, they take that nanoparticle and put it into the cream formulation at a factory site. Then it normally comes out to the consumer encapsulated or protected in one way or another. [emphasis mine]

In general, in those kinds of manufacturing environments the risks are at the start of the process, when you are making the particles and incorporating them into a material, and possibly at the end of the product’s life, when you’re disposing of it. It might then be released in ways that you might not have anticipated—for example, through the wearing down or opening of the cassette of toner or whatever.

I think those are the two areas. Most consumers would see a product in which nanoparticles are encapsulated or incorporated— maybe inside a cellphone, or something like that—and often not be exposed in that way. (p. 7 in print version, p. 9 in PDF)

As I understand Petersen’s comments, he believes that the nanoparticles in sunscreens (and other cosmetics) do not make direct contact as they are somehow incorporated into a shell or capsule. He then makes a comparison to cell phones to prove his point. This is incorrect. Yes, any nanomaterials in a cell phone are bound to the product (cell phones are not rubbed onto the skin) but the nanoparticles in sunscreens make direct contact and *penetrate the skin. *ETA June 28, 2010: It has not been unequivocally proved that nanoparticles penetrate healthy adult skin. I apologize for the error. ** ETA July 19, 2010: As per the July 18, 2010 posting on Andrew Maynard’s 2020 Science blog, the evidence so far suggests that there is no skin penetration by nanoparticles in sunscreens.

I have posted extensively about nanoparticles and sunscreens and will try later to lay in some links either to my posts or to more informed parties as to safety issues regarding consumers.

There was an interesting development towards the end of the meeting with Carolyn Bennett, St. Paul’s,

Firstly, I wanted to apologize for being late. I think some of you know it was the tenth anniversary of CIHR [Canadian Institutes of Health Research] this morning, the breakfast, and some of us who were there at the birth were supposed to be there at the birthday party. So my apologies.

What happened on the way in to the breakfast was that I ran into Liz Dowdeswell, from the Council of Canadian Academies, and it seems that they have just done a review of nanotechnology in terms of pros and cons. [emphasis mine]So I would first ask the clerk and the analyst to circulate that report to the committee, because I think it might be very helpful to us, and then I think it would be interesting to know if the witnesses had seen it and whether they had further comments on whether you felt it was taking Canada in the right direction.

The report mentioned by Bennett was released in July 8, 2008 (news release). You can find the full report here and the abridged version here.

I wouldn’t describe this report as having just been “done” but I think that as a primer it stands up well. (You can read my 2008 comments here.)

I do find it sad that neither this committee nor Peter Julian the Member of Parliament who earlier this year tabled the first bill concerned with nanotechnology were aware of the report’s existence. It adds weight to an issue (nobody in Ottawa seems to be aware of their work) for the Council of Canadian Academies mentioned on this blog here (where you will find links to a more informed discussion by Rob Annan at Don’t leave Canada behind and the folks at The Black Hole).

I’m glad to see there’s some interest in nanotechnology in Ottawa and I hope they continue to dig for more information.

I have sent Joyce Murray a set of questions which I hope she’ll answer about the committee’s interest in nanotechnology and about the science resources and advice available to the Members of Parliament.

ETA June 30, 2010: I received this correction from Mr. Julian’s office today:

I would like to bring to your attention incorrect information provided in the Frogheart posting on June 23, Nanomaterials, Toxicity, and Canada’s House of Commons Standing Committee on Health. Of particular concern are the closing comments:

“I do find it sad that neither this committee nor Peter Julian the Member of Parliament who earlier this year tabled the first bill concerned with nanotechnology were aware of the report’s existence. It adds weight to an issue (nobody in Ottawa seems to be aware of their work) for the Council of Canadian Academies mentioned on this blog here (where you will find links to a more informed discussion by Rob Annan at Don’t leave Canada behind and the folks at The Black Hole). I’m glad to see there’s some interest in nanotechnology in Ottawa and I hope they continue to dig for more information.”

Mr. Julian is indeed aware of the Council of Canadian Academies excellent report on nanotechnology in 2008. The document is one of many that formed the basis of Mr. Julian’s Bill C-494 which was tabled in Parliament on March 10. It is incorrect to assume that Mr. Julian was not aware of the report’s existence.

There is indeed interest in nanotechnology in Ottawa. Canadians should expect sustained interest when the House of Commons reconvenes in September with a focus on better ensuring that nanotechnology’s benefits are safely produced in the marketplace.

I apologize for the error and I shouldn’t have made the assumption. I am puzzled that the Council of Canadian Academies report was not mentioned in the interview Mr. Julian very kindly gave me and where I explicitly requested some recommendations for Canadians who want to read up about nanotechnology. Mr. Julian’s reply (part 2 of the interview) did not include a reference to the Council’s nanotechnology report, which I consider more readable than some of the suggestions offered.

*’haring’ changed to ‘hearing’ on July 26, 2016.

Nanotechnology and the Council of Canadian Academies assessment report

I started discussing the Council of Canadian Academies and its mid-term assessment report (Review of the Council of Canadian Academies; Report from the External Evaluation Panel 2010) yesterday and will finish today with my thoughts on the assessment of the Council’s nanotechnology report and its impact.

Titled Small is Different: A Science Perspective of the Regulatory Challenges on the Nanoscale (2008), the Council’s report is one of the best I’ve read. I highly recommend it to anyone who wants an introduction to some of the issues (and was much struck by its omission from the list of suggested nanotechnology readings that Peter Julian [Canadian MP] offered in part 2 of his interview).  Interestingly, the Council’s nanotechnology report is Case Study No. 3 in the mid-term expert panel assessment report’s Annex 6 (p. 33 in the print version and p. 37 in PDF).

Many respondents were concerned that Health Canada has made no response to, or use of, this report. However, Health Canada respondents were highly enthusiastic about the assessment and the ways in which it is being used to inform the department’s many – albeit still entirely internal – regulatory development activities: “We’ve all read it and used it. The fact that we haven’t responded to the outside is actually a reflection of how busy we’ve been responding to the file on the inside!” [emphases mine]

The report has been particularly valuable in providing a framework to bring together Health Canada’s five – very different – regulatory regimes to identify a common approach and priorities. The sponsor believes the report’s findings have been well-incorporated into its draft working definition of nanomaterials, [emphasis mine] its work with Canadian and international standards agencies, its development of a regulatory framework to address shorter- and longer-term needs, and its creation of a research agenda to aid the development of the science needed to underpin the regulation of nanomaterials in Canada.

I think the next time somebody confronts me as to why I haven’t responded externally to some notice (e.g., paid my strata fees), I’ll assure them that I’ve been ‘responding on the inside’. (Sometimes I cannot resist the low-hanging fruit and I just have to take a bite.)

As for the second paragraph where they claim that Health Canada has incorporated suggestions from the report for its nanomaterials definition, that’s all well and good but the thinking is changing and Health Canada doesn’t seem to be responding (or to even be aware of the fact). Take a look at the proposed definition in the current draft bill before the US Senate where in addition to size, they mention shape, reactivity, and more as compared the Health Canada 1 to 100 nm. size definition. (See details in this posting from earlier in the week where I compare the proposed US and Canadian definitions.)

Additionally, I think they need to find ways to measure impact that are quantitative as well as this qualitative approach, which itself needs to be revised. Quantitative measures could include the numbers of reports disseminated in print and online, social networking efforts (if any), number of times reports are mentioned in the media, etc. They may also want to limit case studies in future reports so they can provide more depth. The comment about the ‘internal’ impact could have been described at more length. How have the five different Health Canada regulatory regimes come together? Has something substantive occurred?

Finally, it’s hard to know if the Julian’s failure to mention the council’s report in his list of nanotechnology readings is a simple failure of memory or a reflection of the Council’s “invisibility”. I’m inclined to believe that it’s the latter.