Tag Archives: regulation

Genetic engineering: an eggplant in Bangladesh and a synthetic biology grant at Concordia University (Canada)

I have two bits of genetic engineering news.

Eggplants in Bangladesh

I always marvel at their beauty,

Bt eggplant is the first genetically engineered food crop to be successfully introduced in South Asia. The crop is helping some of the world’s poorest farmers feed their families and communities while reducing the use of pesticides. Photo by Cornell Alliance for Science.

A July 17, 2018 news item on phys.org describes a genetic engineering application,

Ansar Ali earned just 11,000 taka – about $130 U.S. dollars – from eggplant he grew last year in Bangladesh. This year, after planting Bt eggplant, he brought home more than double that amount, 27,000 taka. It’s a life-changing improvement for a subsistence farmer like Ali.

Bt eggplant, or brinjal as it’s known in Bangladesh, is the first genetically engineered food crop to be successfully introduced in South Asia. Bt brinjal is helping some of the world’s poorest farmers to feed their families and communities, improve profits and dramatically reduce pesticide use. That’s according to Tony Shelton, Cornell professor of entomology and director of the Bt brinjal project funded by the United States Agency for International Development (USAID). Shelton and Jahangir Hossain, the country coordinator for the project in Bangladesh, lead the Cornell initiative to get these seeds into the hands of the small-scale, resource-poor farmers who grow a crop consumed daily by millions of Bangladeshis.

A July 11, 2018 Cornell University news release by Krisy Gashler, which originated the news item, expands on the theme (Note: Links have been removed),

Bt brinjal was first developed by the Indian seed company Mahyco in the early 2000s. Scientists inserted a gene from the bacterium Bacillus thuringiensis (thus the name, Bt) into nine brinjal varieties. The plants were engineered to resist the fruit and shoot borer, a devastating insect whose larvae bore into the stem and fruit of an eggplant. The insects cause up to 80 percent crop loss.

The Bt protein produced by the engineered eggplant causes the fruit and shoot borer larva to stop feeding, but is safe for humans consuming the eggplant, as proven through years of biosafety trials. In fact, Bt is commonly used by organic farmers to control caterpillars but has to be sprayed frequently to be effective. The Bt eggplant produces essentially the same protein as in the spray. More than 80 percent of field corn and cotton grown in the U.S. contains a Bt gene for insect control.

“Farmers growing Bt brinjal in Bangladesh are seeing three times the production of other brinjal varieties, at half the production cost, and are getting better prices at the market,” Hossain said.

A recent survey found 50 percent of farmers in Bangladesh said that they experienced illness due to the intense spraying of insecticides. Most farmers work in bare feet and without eye protection, leading to pesticide exposure that causes skin and eye irritation, and vomiting.

“It’s terrible for these farmers’ health and the health of the environment to spray so much,” said Shelton, who found that pesticide use on Bt eggplant was reduced as much as 92 percent in commercial Bt brinjal plantings. “Bt brinjal is a solution that’s really making a difference in people’s lives.”

Alhaz Uddin, a farmer in the Tangail district, made 6,000 taka growing traditional brinjal, but had to spend 4,000 taka on pesticides to combat fruit and shoot borer.

“I sprayed pesticides several times in a week,” he said. “I got sick many times during the spray.”

Mahyco initially wanted to introduce Bt brinjal in India and underwent years of successful safety testing. But in 2010, due to pressure from anti-biotechnology groups, the Indian minister of the environment placed a moratorium on the seeds. It is still in effect today, leaving brinjal farmers there without the effective and safe method of control available to their neighbors in Bangladesh.

Even before the Indian moratorium, Cornell scientists hosted delegations from Bangladesh that wanted to learn about Bt brinjal and the Agricultural Biotechnology Support Project II (ABSP II), a consortium of public and private institutions in Asia and Africa intended to help with the commercial development, regulatory approval and dissemination of bio-engineered crops, including Bt brinjal.

Cornell worked with USAID, Mahyco and the Bangladesh Agricultural Research Institute to secure regulatory approval, and in 2014 the Bangladeshi government distributed a small number of Bt brinjal plants to 20 farmers in four districts. The next year 108 farmers grew Bt brinjal, and the following year the number of farmers more than doubled to 250. In 2017 the number increased to 6,512 and in 2018 to 27,012. The numbers are likely even higher, according to Shelton, as there are no constraints against farmers saving seeds and replanting.

“Farmers who plant Bt brinjal are required to plant a small perimeter of traditional brinjal around the Bt variety; research has shown that the insects will infest plants in the buffer area, and this will slow their evolutionary development of resistance to the Bt plants,” Shelton said.

In a March 2017 workshop, Bangladeshi Agriculture Minister Begum Matia Chowdhury called Bt brinjal “a success story of local and foreign collaboration.”

“We will be guided by the science-based information, not by the nonscientific whispering of a section of people,” Chowdhury said. “As human beings, it is our moral obligation that all people in our country should get food and not go to bed on an empty stomach. Biotechnology can play an important role in this effect.”

Here’s what an infested eggplant looks like,

Non-Bt eggplant infested with fruit and shoot borer. Photo by Cornell Alliance for Science

It looks more like a fig than an eggplant.

This is part of a more comprehensive project as revealed in a March 29, 2016 Cornell University news release issued on the occasion of a $4.8M, three-year grant from the U.S. Agency for International Development (USAID),

… The award supports USAID’s work under Feed the Future, the U.S. government’s global initiative to fight hunger and improve food security using agricultural science and technology.

In the Feed the Future South Asia Eggplant Improvement Partnership, Cornell will protect eggplant farmers from yield losses and improve their livelihoods in partnership with the Bangladesh Agricultural Research Institute (BARI) and the University of the Philippines at Los Baños. Eggplant, or brinjal, is a staple crop that is an important source of income and nutrition for farmers and consumers in South Asia.

Over the past decade, Cornell has led the Agricultural Biotechnology Support Project II (ABSPII), also funded by USAID, that prompted a consortium of institutions in Asia and Africa to use the tools of modern biotechnology, particularly genetic engineering, to improve crops to address major production constraints for which conventional plant breeding tools have not been effective.

In October 2013, Bangladesh became the first country in South Asia to approve commercial cultivation of a genetically engineered food crop. In February 2014, Matia Chowdhury, the Bangladesh minister of agriculture, released four varieties of Bt brinjal to 20 farmers. With the establishment of the 20 Bt brinjal demonstration plots in 2014 and 104 more in 2015, BARI reported a noticeable decrease in fruit and shoot borer infestation, increased yields, decreased use of pesticide and improved income for farmers.

The Feed the Future South Asia Eggplant Improvement Partnership addresses and integrates all elements of the commercialization process — including technology development, regulation, marketing, seed distribution, and product stewardship. It also provides strong platforms for policy development, capacity building, gender equality, outreach and communication.

Moving on from practical applications …

Canada’s synthetic biology training centre

It seems Concordia University (Montréa) is a major Canadian centre for all things ‘synthetic biological’. (from the History and Vision webpage on Concordia University’s Centre for Applied Synthetic Biology webspace),

History and vision

Emerging in 2012 from a collaboration between the Biology and Electrical and Computer Engineering Departments, the Centre received University-wide status in 2016 growing its membership to include Biochemistry, Journalism, Communication Studies, Mechanical, Industrial and Chemical Engineering.


Timeline

T17-36393-VPRG-Timeline-graphic-promo-v4

You can see the timeline does not yet include 2018 development(s). Also it started as “a collaboration between the Biology and Electrical and Computer Engineering Departments?” This suggests a vastly different approach to genetic engineering that that employed in the “eggplant” research. From a July 16, 2018 posting on the Genome Alberta blog,

The Natural Sciences and Engineering Research Council of Canada (NSERC) has committed $1.65 million dollars over six years to establish a research and training program at Concordia’s Centre for Applied Synthetic Biology.

The funds were awarded after Malcolm Whiteway (…), professor of biology and the Canada Research Chair in Microbial Genomics, and the grant application team submitted a proposal to NSERC’s Collaborative Research and Training Experience (CREATE) program.

The Synthetic Biology Applications CREATE program — or SynBioApps — will help students acquire and develop important professional skills that complement their academic education and improve their job-readiness.

‘Concordia is a natural fit’

“As the Canadian leader in synthetic biology and as the home of the country’s only genome foundry, Concordia is a natural fit for a training program in this growing area of research,” says Christophe Guy, vice-president of Research and Graduate Studies.

“In offering a program like SynBioApps, we are providing our students with both a fundamental education in science and the business skills they’ll need to transition into their professional careers.”

The program’s aims are twofold: First, it will teach students how to design and construct cells and proteins for the development of new products related to human health, green technologies, and fundamental biological investigations. Second, it will provide cross-disciplinary training and internship opportunities through the university’s District 3 Innovation Center.

SynBioApps will be open to students from biology, biochemistry, engineering, computing, and mathematics.

“The ability to apply engineering approaches to biological systems promises to revolutionize both biology and industry,” says Whiteway, who is also a member of the Centre for Applied Synthetic Biology.

“The SynBioApps program at Concordia will provide a training program to develop the students who will both investigate the biology and build these industries.”

You can find out more about Concordia’s Centre for Applied Synthetic Biology here (there are jobs listed on their home page) and you can find information about the Synthetic Biology Applications (SynBioApps) training programme here.

Voluntary regulation and oversight for nanotechnology: a review

It’s been a while since I’ve had an invite for a Project on Emerging Technologies (PEN) event. November 4, 2010, the organization will be hosting an event hosting the release of a new report (from the news release),

Join us on Thursday, November 4, 2010, at 12:30 p.m. for the release of Voluntary Initiatives, Regulation, and Nanotechnology Oversight: Charting a Path, a new PEN report by Dr. Daniel Fiorino followed by a commentary by J. Clarence (Terry) Davies.“This report is the most extensive analysis done to date of how voluntary programs can be applied to managing nanotechnology’s possible environmental and health effects,” said David Rejeski, Director of the project. “The report’s analysis and recommendations extend beyond nanotechnology to the newer generation challenges that we face as science rapidly advances.”

Given that most voluntary programmes run by governments have been deemed a failure, I’m quite interested in hearing about how voluntary programmes could be better implemented.

If you’re in Washington, DC and want to attend in person, you will need to RSVP for the event (they’re serving a light lunch at 12 noon EST) which takes place from 12:30 pm to 1:30 pm EST.

The event is livestreamed in a webcast.

Peter Julian interview on tabling the first nanotechnology bill in Canada’s parliament (part 1 of 3); musings on oil-rich regions and nanotechnology

In mid-March 2010, Member of Parliament, Peter Julian, NDP (New Democrat Party) tabled the first Canadian bill (ETA June 22, 2010: Bill C-494) to regulate nanotechnology. Kudos to him for bringing nanotechnology into a national public forum and hopefully inspiring some discussion and debate.

Mr. Julian kindly agreed (thank you!) to answer some e-mail interview questions which I will be posting in a 3-part interview starting today where he answers questions about why he tabled the bill, the involvement of the NDP’s science shadow minister, and the state of the NDP’s science policy.

For anyone who’s not familiar with Mr. Julian, I got some biographical information from his constituency website,

Peter Julian

Member of Parliament, Burnaby–New Westminster
International Trade
Asia-Pacific Gateway
Deputy Critic Fisheries (West Coast Fisheries)
2010 Olympics

  • Has been the most active MP from Western Canada so far in the 40th Parliament.
  • First elected Member of Parliament for Burnaby-New Westminster in 2004 (by a narrow margin of 300 votes), and re-elected in 2006 (by 4,000 votes) and again in 2008 (by 7,000 votes).
  • Served as Critic on International Trade, Transportation, Persons with Disabilities, Gateways and the Vancouver 2010 Olympics in 39th Parliament; Critic on International Trade, the Treasury Board, Transportation and Persons with Disabilities in 38th Parliament.
  • Ranked fifth of 308 MPs in crafting of Private Member’s legislation in 39th Parliament including tougher drunk driving laws and eliminating toxic substances found in fire retardants.
  • Most active rookie in the House of Commons in the 38th Parliament.
  • Prominent critic of Harper Conservatives’ softwood lumber sellout. Called “the Iron Man” by CTV’s David Akin for determination to stop the sellout.
  • Previously a financial administrator, community activist and manual labourer. Served as National Executive Director of Council of Canadians – (founding member), former Executive Director of the Western Institute for the Deaf and Hard of Hearing (WIDHH).
  • Instrumental in building the British Columbia Disability Employment Network
  • Former National Policy Coordinator and Assistant and Acting Federal Secretary of the New Democratic Party of Canada.

Now on to the interview:

What was the impetus for including nanotechnology as part of this bill? i.e. was there some specific incident or has this been an ongoing concern?

The major forces for including my bill on nanotechnology were; the concerns raised by constituents, the progressive work done by the European Union (including the EU Council Directive on cosmetic products and the January 2010 report of the UK’s House of Lords Science and Technology Committee Report). In contrast Canada has made minimal progress towards ensuring that nanotechnology discoveries are safely introduced into the marketplace, environment, and to Canadians.

The exponential increase in applications and products using this type of technology makes updating the regulatory framework necessary. A regulatory vacuum cannot persist if the commercial and societal promises of nanotechnologies are to be fulfilled. There are trade and safety implications involved.

A modernized regulatory framework, based on precaution given the rapid evolution of nanotechnologies, would help ensure that Canadians will be protected from unintended effects. At the same time, it would enable Canadian businesses to enjoy a predictable regulatory environment for investment and innovation, for nanotechnology is a key driver in Canada’s continued growth via sustainable development.

The following are the key components of Bill C-494:

A) A definition of Nanotechnology definition based on “nanometre scale” (1-1000nm),

B) Prescribed Government of Canada research and studies, with the precautionary principle providing direction for a ‘life-cycle’ approach to nanotechnology, and,

C) A Nanotechnology Inventory established and published.

I believe that the definition contained in Bill C-494 constitutes the first legislative body effort since UK House of Lords Committee recommended a similar nanometre scale definition.

Was the NDP’s science shadow minister involved in this bill? What was Jim Malloway’s contribution?

As you may know, private members bills are at the initiative of individual MPs. I have consulted with the NDP Environment and Health critics, in addition to our own research, library of Parliament support, and input from civil society. Jim Malloway and the NDP caucus support the principle of Bill C-494 and share the view that Nanotechnologies present a tremendous opportunity for Canada and that is why safety must be ensured.

Is there going to be more interest in science policy from the NDP?

The NDP is focused on securing sound foundations for science policy by making sure the government has enough resources to support the development of science while monitoring the consequences. We are also focused on ensuring that funding for post secondary education is appropriate and the resources and knowhow of the public sector are not trivialized and outsourced. The civil service needs a critical mass of expertise to support a healthy science development policy. We must encourage and preserve independent research at the university level and make sure that it is not subservient to corporate funding. Science must be allowed to evolve regardless of the commercial aspect. Our small caucus is focused on helping create these conditions where Canadian science and its applications can flourish in both private and not-for-profit spheres, with appropriate regulatory safeguards.

Tomorrow: Mr. Julian answers questions about the ‘precautionary principle’ and the research that supports his bill.

Peter Julian interview Part 2, Part 3, Comments: Nano Ontario, Comments: nanoAlberta

Oil-rich regions and nano

I had a few idle thoughts on seeing a notice on Nanowerk in mid-March that Iran has published a national nanotechnology standard. From the notice on Nanowerk,

The committee of Iranian nanotechnology standardization chose 49 main words in nanotechnology by means of ISO, BSI, and ASTM published standards and translated their definitions into Persian in cooperation with a team from Persian Language and Literature Academy.

The words like nanotechnology, nanomaterials, nanoparticle, nanoscale, nanotube, nanosystem etc have been defined in this standard.

(I did click on the link for the publication but unfortunately there doesn’t seem to be an English language version available.)

I find it interesting that there is so much activity on the nanotechnology front in Iran and other other oil-producing regions including Alberta (Canada) which hosts the National Institute for Nanotechnology and gets a great deal of funding from the Alberta provincial government. Texas, also known for its oil, hosts a leader in nanotechnology research, Rice University which is celebrating its 25th anniversary as the site where ‘bucky balls’ or buckminster fullerenes were first discovered. In Saudi Arabia, they opened KAUST (King Abdullah University for Science and Technology) in September 2009. While the ambitions range far beyond (the Saudis hope to establish a modern ‘House of Wisdom’) nanotechnology, its research is an important element in the overall scheme of things. I guess the reason that all these areas which are known for their oil production are so invested in nanotechnology is that they know time is running out and they need new ways to keep their economies afloat.

Quick peek at nanotechnologies and food report from UK House of Lords

After getting  an advance copy of the new report from the UK’s House of Lords Science, Technology and Industry Committee (mentioned in my post of Jan.5.10), I spent a good chunk of the day reading it. These are fast impressions:

  • it seemed quite thorough relative to the scope of the investigation and from the perspective of a Canadian who hasn’t seen her own government investigate and make public information about the state of any nanotechnology research, I found this to be quite refreshing
  • there was something strange about the benefits and that strangeness was the focus on obesity and waste…much else is mentioned but obesity and waste (i.e. reducing both) are strongly emphasized as possible areas where benefits could be experienced.
  • secrecy on the part of the food industry’s nanotechnology research was noted and discussed at length with an analysis that was both sympathetic to the industry’s concerns (i.e. that there would be a replay of the GM and food irradiation controversies and/or competition would be inhibited) and adamant that adopting secrecy as a strategy is wrong-minded.
  • nanotechnology research in the UK is coordinated through a single agency (I believe that’s true in the US as well but it’s definitely not the case in Canada).
  • they were quite critical of the current toxicology research efforts, irrespective of nanotechnology, there aren’t enough toxicology researchers in the UK as well there’s a specific problem with the nanotoxicology, i.e. knowledge gaps (from the report [and they are quoting from a previous report], pp. 34-5 ),

EMERGNANO report states that “this review of ongoing studies has failed to demonstrate that there is any comprehensive attempt to gain the toxicokinetic … data required to reach the aims of hazard identification” and there have been “no systematic studies on the potential of different kinds of nanoparticles to get into the blood, the lymph or the brain”. We find this conclusion worrying.

We are disappointed and concerned that the Research Councils have not adopted a more pro-active approach to encourage and stimulate research bids in areas where existing mechanisms have so far proved ineffective. Dr Mulkeen told us that the MRC would take “more active steps if needed” to develop research into the safety of nanotechnologies (Q 420). We feel that a more pro-active stance is essential given the lack of progress in several key areas to date.

  • some of the difficulty re: nanotoxicology research seems to be attributable to the funding structure (from the report p. 35),

The 2007 review by the CST concluded that the primary reason for the Government’s slow progress on health and safety research was due “to an over-reliance by Government on responsive mode funding, rather than on directed programmes by Government departments to deliver the necessary research”.44 A number of witnesses supported this view. Professor Donaldson, for example, told us: “If we look at the Royal Academy/Royal Society report, there was a really important paragraph that there should be a central core-funded chunk of research and expertise brought together to design a programme that would look systematically at nanoparticle toxicology, and that was ignored. We had response mode funding where people just put forward what they wanted to do, so what you get is piecemeal” (Q 267).
Professor Jones also alluded to the relative strength of research investigating nanoparticle toxicology in the lung compared to a lack of research into the
gut as a result of response-mode funding (Q 494).

  • there is a huge difference between the funds for nanotechnology research (one agency spent 220 million pounds on nanotech research over a 5 year period) and funds for nanotoxicology research (less than 600,000 pounds per annum or less than 3 million pounds in a five year period) which I imagine is much  the same elsewhere.
  • they do mention Canada as a country that has announced a mandatory register of nanomaterials which will include information on safety data (this register has been referred to in other reports but no one ever cites a source and I’ve never been able to confirm that this register is actually being developed).
  • in their recommendations for regulatory enforcement they seemed to be reinforcing the status quo or bringing the UK into line with current European Union practices.
  • in the last bit they discuss communication, i.e. there should be yet another survey of public attitudes although this will be about nanotechnologies and food, they acknowledge the government’s decision to create a new website on the subject, they’d like it if the government would work with the industry folks to become more open about their research, there won’t be blanket labelling of nanotechnology on  food products, and they think public engagement should be undertaken.

The last two bits, regulation and communication, are the least developed sections of the report. I found that overall there was a good balance between sympathy for industry interests and concern for health issues. Some of the strongest language in the report was used in the sections on nanotoxicology and its lack of research.