Tag Archives: Singapore

Graphene Malaysia 2016 gathering and Malaysia’s National Graphene Action Plan 2020

Malaysia is getting ready to host a graphene conference according to an Oct. 10, 2016 news item on Nanotechnology Now,

The Graphene Malaysia 2016 [Nov. 8 – 9, 2016] (www.graphenemalaysiaconf.com) is jointly organized by NanoMalaysia Berhad and Phantoms Foundation. The conference will be centered on graphene industry interaction and collaborative innovation. The event will be launched under the National Graphene Action Plan 2020 (NGAP 2020), which will generate about 9,000 jobs and RM20 (US$4.86) billion GNI impact by the year 2020.

First speakers announced:
Murni Ali (Nanomalaysia, Malaysia) | Francesco Bonaccorso (Istituto Italiano di Tecnologia, Italy) | Antonio Castro Neto (NUS, Singapore) | Antonio Correia (Phantoms Foundation, Spain)| Pedro Gomez-Romero (ICN2 (CSIC-BIST), Spain) | Shu-Jen Han (Nanoscale Science & Technology IBM T.J. Watson Research Center, USA) | Kuan-Tsae Huang (AzTrong, USA/Taiwan) | Krzysztof Koziol (FGV Cambridge Nanosystems, UK) | Taavi Madiberk (Skeleton Technologies, Estonia) | Richard Mckie (BAE Systems, UK) | Pontus Nordin (Saab AB, Saab Aeronautics, Sweden) | Elena Polyakova (Graphene Laboratories Inc., USA) | Ahmad Khairuddin Abdul Rahim (Malaysian Investment Development Authority (MIDA), Malaysia) | Adisorn Tuantranont (Thailand Organic and Printed Electronics Innovation Center, Thailand) |Archana Venugopal (Texas Instruments, USA) | Won Jong Yoo (Samsung-SKKU Graphene-2D Center (SSGC), South Korea) | Hongwei Zhu (Tsinghua University, China)

You can check for more information and deadlines in the Nanotechnology Now Oct. 10, 2016 news item.

The Graphene Malalysia 2016 conference website can be found here and Malaysia’s National Graphene Action Plan 2020, which is well written, can be found here (PDF).  This portion from the executive summary offers some insight into Malyasia’s plans to launch itself into the world of high income nations,

Malaysia’s aspiration to become a high-income nation by 2020 with improved jobs and better outputs is driving the country’s shift away from “business as usual,” and towards more innovative and high value add products. Within this context, and in accordance with National policies and guidelines, Graphene, an emerging, highly versatile carbon-based nanomaterial, presents a unique opportunity for Malaysia to develop a high value economic ecosystem within its industries.  Isolated only in 2004, Graphene’s superior physical properties such as electrical/ thermal conductivity, high strength and high optical transparency, combined with its manufacturability have raised tremendous possibilities for its application across several functions and make it highly interesting for several applications and industries.  Currently, Graphene is still early in its development cycle, affording Malaysian companies time to develop their own applications instead of relying on international intellectual property and licenses.

Considering the potential, several leading countries are investing heavily in associated R&D. Approaches to Graphene research range from an expansive R&D focus (e.g., U.S. and the EU) to more focused approaches aimed at enhancing specific downstream applications with Graphene (e.g., South Korea). Faced with the need to push forward a multitude of development priorities, Malaysia must be targeted in its efforts to capture Graphene’s potential, both in terms of “how to compete” and “where to compete”. This National Graphene Action Plan 2020 lays out a set of priority applications that will be beneficial to the country as a whole and what the government will do to support these efforts.

Globally, much of the Graphene-related commercial innovation to date has been upstream, with producers developing techniques to manufacture Graphene at scale. There has also been some development in downstream sectors, as companies like Samsung, Bayer MaterialScience, BASF and Siemens explore product enhancement with Graphene in lithium-ion battery anodes and flexible displays, and specialty plastic and rubber composites. However the speed of development has been uneven, offering Malaysian industries willing to invest in innovation an opportunity to capture the value at stake. Since any innovation action plan has to be tailored to the needs and ambitions of local industry, Malaysia will focus its Graphene action plan initially on larger domestic industries (e.g., rubber) and areas already being targeted by the government for innovation such as energy storage for electric vehicles and conductive inks.

In addition to benefiting from the physical properties of Graphene, Malaysian downstream application providers may also capture the benefits of a modest input cost advantage for the domestic production of Graphene.  One commonly used Graphene manufacturing technique, the chemical vapour deposition (CVD) production method, requires methane as an input, which can be sourced economically from local biomass. While Graphene is available commercially from various producers around the world, downstream players may be able to enjoy some cost advantage from local Graphene supply. In addition, co-locating with a local producer for joint product development has the added benefit of speeding up the R&D lifecycle.

That business about finding downstream applications could also to the Canadian situation where we typically offer our resources (upstream) but don’t have an active downstream business focus. For example, we have graphite mines in Ontario and Québec which supply graphite flakes for graphene production which is all upstream. Less well developed are any plans for Canadian downstream applications.

Finally, it was interesting to note that the Phantoms Foundation is organizing this Malaysian conference since the same organization is organizing the ‘2nd edition of Graphene & 2D Materials Canada 2016 International Conference & Exhibition’ (you can find out more about the Oct. 18 – 20, 2016 event in my Sept. 23, 2016 posting). I think the Malaysians have a better title for their conference, far less unwieldy.

Innovation and two Canadian universities

I have two news bits and both concern the Canadian universities, the University of British Columbia (UBC) and the University of Toronto (UofT).

Creative Destruction Lab – West

First, the Creative Destruction Lab, a technology commercialization effort based at UofT’s Rotman School of Management, is opening an office in the west according to a Sept. 28, 2016 UBC media release (received via email; Note: Links have been removed; this is a long media release which interestingly does not mention Joseph Schumpeter the man who developed the economic theory which he called: creative destruction),

The UBC Sauder School of Business is launching the Western Canadian version of the Creative Destruction Lab, a successful seed-stage program based at UofT’s Rotman School of Management, to help high-technology ventures driven by university research maximize their commercial impact and benefit to society.

“Creative Destruction Lab – West will provide a much-needed support system to ensure innovations formulated on British Columbia campuses can access the funding they need to scale up and grow in-province,” said Robert Helsley, Dean of the UBC Sauder School of Business. “The success our partners at Rotman have had in helping commercialize the scientific breakthroughs of Canadian talent is remarkable and is exactly what we plan to replicate at UBC Sauder.”

Between 2012 and 2016, companies from CDL’s first four years generated over $800 million in equity value. It has supported a long line of emerging startups, including computer-human interface company Thalmic Labs, which announced nearly USD $120 million in funding on September 19, one of the largest Series B financings in Canadian history.

Focusing on massively scalable high-tech startups, CDL-West will provide coaching from world-leading entrepreneurs, support from dedicated business and science faculty, and access to venture capital. While some of the ventures will originate at UBC, CDL-West will also serve the entire province and extended western region by welcoming ventures from other universities. The program will closely align with existing entrepreneurship programs across UBC, including, e@UBC and HATCH, and actively work with the BC Tech Association [also known as the BC Technology Industry Association] and other partners to offer a critical next step in the venture creation process.

“We created a model for tech venture creation that keeps startups focused on their essential business challenges and dedicated to solving them with world-class support,” said CDL Founder Ajay Agrawal, a professor at the Rotman School of Management and UBC PhD alumnus.

“By partnering with UBC Sauder, we will magnify the impact of CDL by drawing in ventures from one of the country’s other leading research universities and B.C.’s burgeoning startup scene to further build the country’s tech sector and the opportunities for job creation it provides,” said CDL Director, Rachel Harris.

CDL uses a goal-setting model to push ventures along a path toward success. Over nine months, a collective of leading entrepreneurs with experience building and scaling technology companies – called the G7 – sets targets for ventures to hit every eight weeks, with the goal of maximizing their equity-value. Along the way ventures turn to business and technology experts for strategic guidance on how to reach goals, and draw on dedicated UBC Sauder students who apply state-of the-art business skills to help companies decide which market to enter first and how.

Ventures that fail to achieve milestones – approximately 50 per cent in past cohorts – are cut from the process. Those that reach their objectives and graduate from the program attract investment from the G7, as well as other leading venture-capital firms.

Currently being assembled, the CDL-West G7 will be comprised of entrepreneurial luminaries, including Jeff Mallett, the founding President, COO and Director of Yahoo! Inc. from 1995-2002 – a company he led to $4 billion in revenues and grew from a startup to a publicly traded company whose value reached $135 billion. He is now Managing Director of Iconica Partners and Managing Partner of Mallett Sports & Entertainment, with ventures including the San Francisco Giants, AT&T Park and Mission Rock Development, Comcast Bay Area Sports Network, the San Jose Giants, Major League Soccer, Vancouver Whitecaps FC, and a variety of other sports and online ventures.

Already bearing fruit, the Creative Destruction Lab partnership will see several UBC ventures accepted into a Machine Learning Specialist Track run by Rotman’s CDL this fall. This track is designed to create a support network for enterprises focused on artificial intelligence, a research strength at UofT and Canada more generally, which has traditionally migrated to the United States for funding and commercialization. In its second year, CDL-West will launch its own specialist track in an area of strength at UBC that will draw eastern ventures west.

“This new partnership creates the kind of high impact innovation network the Government of Canada wants to encourage,” said Brandon Lee, Canada’s Consul General in San Francisco, who works to connect Canadian innovation to customers and growth capital opportunities in Silicon Valley. “By collaborating across our universities to enhance our capacity to turn the scientific discoveries into businesses in Canada, we can further advance our nation’s global competitiveness in the knowledge-based industries.”

The Creative Destruction Lab is guided by an Advisory Board, co-chaired by Vancouver-based Haig Farris, a pioneer of the Canadian venture capitalist industry, and Bill Graham, Chancellor of Trinity College at UofT and former Canadian cabinet minister.

“By partnering with Rotman, UBC Sauder will be able to scale up its support for high-tech ventures extremely quickly and with tremendous impact,” said Paul Cubbon, Leader of CDL-West and a faculty member at UBC Sauder. “CDL-West will act as a turbo booster for ventures with great ideas, but which lack the strategic roadmap and funding to make them a reality.”

CDL-West launched its competitive application process for the first round of ventures that will begin in January 2017. Interested ventures are encouraged to submit applications via the CDL website at: www.creativedestructionlab.com


UBC Technology ventures represented at media availability

Awake Labs is a wearable technology startup whose products measure and track anxiety in people with Autism Spectrum Disorder to better understand behaviour. Their first device, Reveal, monitors a wearer’s heart-rate, body temperature and sweat levels using high-tech sensors to provide insight into care and promote long term independence.

Acuva Technologies is a Vancouver-based clean technology venture focused on commercializing breakthrough UltraViolet Light Emitting Diode technology for water purification systems. Initially focused on point of use systems for boats, RVs and off grid homes in North American market, where they already have early sales, the company’s goal is to enable water purification in households in developing countries by 2018 and deploy large scale systems by 2021.

Other members of the CDL-West G7 include:

Boris Wertz: One of the top tech early-stage investors in North America and the founding partner of Version One, Wertz is also a board partner with Andreessen Horowitz. Before becoming an investor, Wertz was the Chief Operating Officer of AbeBooks.com, which sold to Amazon in 2008. He was responsible for marketing, business development, product, customer service and international operations. His deep operational experience helps him guide other entrepreneurs to start, build and scale companies.

Lisa Shields: Founder of Hyperwallet Systems Inc., Shields guided Hyperwallet from a technology startup to the leading international payments processor for business to consumer mass payouts. Prior to founding Hyperwallet, Lisa managed payments acceptance and risk management technology teams for high-volume online merchants. She was the founding director of the Wireless Innovation Society of British Columbia and is driven by the social and economic imperatives that shape global payment technologies.

Jeff Booth: Co-founder, President and CEO of Build Direct, a rapidly growing online supplier of home improvement products. Through custom and proprietary web analytics and forecasting tools, BuildDirect is reinventing and redefining how consumers can receive the best prices. BuildDirect has 12 warehouse locations across North America and is headquartered in Vancouver, BC. In 2015, Booth was awarded the BC Technology ‘Person of the Year’ Award by the BC Technology Industry Association.


CDL-west will provide a transformational experience for MBA and senior undergraduate students at UBC Sauder who will act as venture advisors. Replacing traditional classes, students learn by doing during the process of rapid equity-value creation.

Supporting venture development at UBC:

CDL-west will work closely with venture creation programs across UBC to complete the continuum of support aimed at maximizing venture value and investment. It will draw in ventures that are being or have been supported and developed in programs that span campus, including:

University Industry Liaison Office which works to enable research and innovation partnerships with industry, entrepreneurs, government and non-profit organizations.

e@UBC which provides a combination of mentorship, education, venture creation, and seed funding to support UBC students, alumni, faculty and staff.

HATCH, a UBC technology incubator which leverages the expertise of the UBC Sauder School of Business and entrepreneurship@UBC and a seasoned team of domain-specific experts to provide real-world, hands-on guidance in moving from innovative concept to successful venture.

Coast Capital Savings Innovation Hub, a program base at the UBC Sauder Centre for Social Innovation & Impact Investing focused on developing ventures with the goal of creating positive social and environmental impact.

About the Creative Destruction Lab in Toronto:

The Creative Destruction Lab leverages the Rotman School’s leading faculty and industry network as well as its location in the heart of Canada’s business capital to accelerate massively scalable, technology-based ventures that have the potential to transform our social, industrial, and economic landscape. The Lab has had a material impact on many nascent startups, including Deep Genomics, Greenlid, Atomwise, Bridgit, Kepler Communications, Nymi, NVBots, OTI Lumionics, PUSH, Thalmic Labs, Vertical.ai, Revlo, Validere, Growsumo, and VoteCompass, among others. For more information, visit www.creativedestructionlab.com

About the UBC Sauder School of Business

The UBC Sauder School of Business is committed to developing transformational and responsible business leaders for British Columbia and the world. Located in Vancouver, Canada’s gateway to the Pacific Rim, the school is distinguished for its long history of partnership and engagement in Asia, the excellence of its graduates, and the impact of its research which ranks in the top 20 globally. For more information, visit www.sauder.ubc.ca

About the Rotman School of Management

The Rotman School of Management is located in the heart of Canada’s commercial and cultural capital and is part of the University of Toronto, one of the world’s top 20 research universities. The Rotman School fosters a new way to think that enables graduates to tackle today’s global business and societal challenges. For more information, visit www.rotman.utoronto.ca.

It’s good to see a couple of successful (according to the news release) local entrepreneurs on the board although I’m somewhat puzzled by Mallett’s presence since, if memory serves, Yahoo! was not doing that well when he left in 2002. The company was an early success but utterly dwarfed by Google at some point in the early 2000s and these days, its stock (both financial and social) has continued to drift downwards. As for Mallett’s current successes, there is no mention of them.

Reuters Top 100 of the world’s most innovative universities

After reading or skimming through the CDL-West news you might think that the University of Toronto ranked higher than UBC on the Reuters list of the world’s most innovative universities. Before breaking the news about the Canadian rankings, here’s more about the list from a Sept, 28, 2016 Reuters news release (receive via email),

Stanford University, the Massachusetts Institute of Technology and Harvard University top the second annual Reuters Top 100 ranking of the world’s most innovative universities. The Reuters Top 100 ranking aims to identify the institutions doing the most to advance science, invent new technologies and help drive the global economy. Unlike other rankings that often rely entirely or in part on subjective surveys, the ranking uses proprietary data and analysis tools from the Intellectual Property & Science division of Thomson Reuters to examine a series of patent and research-related metrics, and get to the essence of what it means to be truly innovative.

In the fast-changing world of science and technology, if you’re not innovating, you’re falling behind. That’s one of the key findings of this year’s Reuters 100. The 2016 results show that big breakthroughs – even just one highly influential paper or patent – can drive a university way up the list, but when that discovery fades into the past, so does its ranking. Consistency is key, with truly innovative institutions putting out groundbreaking work year after year.

Stanford held fast to its first place ranking by consistently producing new patents and papers that influence researchers elsewhere in academia and in private industry. Researchers at the Massachusetts Institute of Technology (ranked #2) were behind some of the most important innovations of the past century, including the development of digital computers and the completion of the Human Genome Project. Harvard University (ranked #3), is the oldest institution of higher education in the United States, and has produced 47 Nobel laureates over the course of its 380-year history.

Some universities saw significant movement up the list, including, most notably, the University of Chicago, which jumped from #71 last year to #47 in 2016. Other list-climbers include the Netherlands’ Delft University of Technology (#73 to #44) and South Korea’s Sungkyunkwan University (#66 to #46).

The United States continues to dominate the list, with 46 universities in the top 100; Japan is once again the second best performing country, with nine universities. France and South Korea are tied in third, each with eight. Germany has seven ranked universities; the United Kingdom has five; Switzerland, Belgium and Israel have three; Denmark, China and Canada have two; and the Netherlands and Singapore each have one.

You can find the rankings here (scroll down about 75% of the way) and for the impatient, the University of British Columbia ranked 50th and the University of Toronto 57th.

The biggest surprise for me was that China, like Canada, had two universities on the list. I imagine that will change as China continues its quest for science and innovation dominance. Given how they tout their innovation prowess, I had one other surprise, the University of Waterloo’s absence.

Barnacle footprints could be useful

An Aug. 18, 2016 news item on Nanowerk describes efforts by scientists at the University of Twente (The Netherlands) and A*STAR (Singapore) to trace a barnacle’s footprints (Note: A link has been removed),

Barnacle’s larvae leave behind tiny protein traces on a ship hull: but what is the type of protein and what is the protein-surface interaction? Conventional techniques can only identify dissolved proteins, and in large quantities. Using a modified type of an Atomic Force Microscope, scientists of the University of Twente in The Netherlands and A*STAR in Singapore, can now measure protein characteristics of even very small traces on a surface. They present the new technique in Nature Nanotechnology (“Measuring protein isoelectric points by AFM-based force spectroscopy using trace amounts of sample”).

An Aug. 16, 2016 University of Twente press release, which originated the news item, explains how the ‘footprints’ could lead to new applications for ships and boats and briefly describes the technical aspects of the research,

In infection diseases, membrane fouling, interaction with bacteria, as well as in rapid healing of wounds for example, the way proteins interact with a surface plays an important role. On a surface, they function in a different way than in solution. On a ship hull, the larvae of the barnacle will leave tiny traces of protein to test if the surface is attractive for long-term attachment. If we get to know more about this interaction, it will be possible to develop surface conditions that are less attractive for the barnacle. Large amounts of barnacles on a ship will have a destructive effect on flow resistance and will lead to more fuel consumption. The new measuring method makes use of a modified Atomic Force Microscope: a tiny ball glued to the cantilever of the microscope will attract protein molecules.

Modified AFM tip with a tiny ball that can attract protein molecules


An amount of just hundreds of protein molecules will be sufficient to determine a crucial value, called the iso-electric point (pI): this is the pH-value at which the protein has net zero electric charge. The pI value says a lot about the surroundings a protein will ‘feel comfortable’ in, and to which it preferably moves. Using the AFM microscope, of which the modified tip has collected protein molecules, it is possible to perform force measurements for different pH values. The tip will be attracted or repelled, or show no movement when the pI point is reached. For these measurement, the researchers made a special reference material consisting of several layers. Using this, the effect of a number of pH-values can be tested until the pI value is found.

The traces the larve leaves behind (left) and force measurements (right)


The tests have been successfully performed for a number of known proteins like fibrinogen, myoglobine and bovine albumin. And returning to the barnacle: the tiny protein footprint will contain enough molecules to determine the pI value. This quantifies the ideal surface conditions, and using this knowledge, new choices can be made for e.g. the paint that is used on a ship hull.

The research has been done within the group Materials Science and Technology of Polymers of Professor Julius Vancso, in close collaboration with colleagues of A*STAR in Singapore – Prof Vancso is a Visiting Professor there as well. His group is part of UT’s MESA+ Institute for Nanotechnology.

Here’s a link to and a citation for the paper,

Measuring protein isoelectric points by AFM-based force spectroscopy using trace amounts of sample by Shifeng Gu, Xiaoying Zhu, Dominik Jańczewski, Serina Siew Chen Lee, Tao He, Serena Lay Ming Teo, & G. Julius Vancso.  Nature Nanotechnology (2016) doi:10.1038/nnano.2016.118 Published online 25 July 2016

This paper is behind a paywall.

Robots judge a beauty contest

I have a lot of respect for good PR gimmicks and a beauty contest judged by robots (or more accurately, artificial intelligence) is a provocative idea wrapped up in a good public relations (PR) gimmick. A July 12, 2016 In Silico Medicine press release on EurekAlert reveals more,

Beauty.AI 2.0, a platform,” a platform, where human beauty is evaluated by a jury of robots and algorithm developers compete on novel applications of machine intelligence to perception is supported by Ernst and Young.

“We were very impressed by E&Y’s recent advertising campaign with a robot hand holding a beautiful butterfly and a slogan “How human is your algorithm?” and immediately invited them to participate. This slogan captures the very essence of our contest, which is constantly exploring new ideas in machine perception of humans”, said Anastasia Georgievskaya, Managing Scientist at Youth Laboratories, the organizer of Beauty.AI.

Beauty.AI contest is supported by the many innovative companies from the US, Europe, and Asia with some of the top cosmetics companies participating in collaborative research projects. Imagene Labs, one of the leaders in linking facial and biological information from Singapore operating across Asia, is a gold sponsor and research partner of the contest.

There are many approaches to evaluating human beauty. Features like symmetry, pigmentation, pimples, wrinkles may play a role and similarity to actors, models and celebrities may be used in the calculation of the overall score. However, other innovative approaches have been proposed. A robot developed by Insilico Medicine compares the chronological age with the age predicted by a deep neural network. Another team is training an artificially-intelligent system to identify features that contribute to the popularity of the people on dating sites.

“We look forward to collaborating with the Youth Laboratories team to create new AI algorithms. These will eventually allow consumers to objectively evaluate how well their wellness interventions – such as diet, exercise, skincare and supplements – are working. Based on the results they can then fine tune their approach to further improve their well-being and age better”, said Jia-Yi Har, Vice President of Imagene Labs.

The contest is open to anyone with a modern smartphone running either Android or iOS operating system, and Beauty.AI 2.0 app can be downloaded for free from either Google or Apple markets. Programmers and companies can participate by submitting their algorithm to the organizers through the Beauty.AI website.

“The beauty of Beauty.AI pageants is that algorithms are much more impartial than humans, and we are trying to prevent any racial bias and run the contest in multiple age categories. Most of the popular beauty contests discriminate by age, gender, marital status, body weight and race. Algorithms are much less partial”, said Alex Shevtsov, CEO of Youth Laboratories.

Very interesting take on beauty and bias. I wonder if they’re building change into their algorithms. After all, standards for beauty don’t remain static, they change over time.

Unfortunately, that question isn’t asked in Wency Leung’s July 4, 2016 article on the robot beauty contest for the Globe and Mail but she does provides more details about the contest and insight into the world of international cosmetics companies and their use of technology,

Teaching computers about aesthetics involves designing sophisticated algorithms to recognize and measure features like wrinkles, face proportions, blemishes and skin colour. And the beauty industry is rapidly embracing these high-tech tools to respond to consumers’ demand for products that suit their individual tastes and attributes.

Companies like Sephora and Avon, for instance, are using face simulation technology to provide apps that allow customers to virtually try on and shop for lipsticks and eye shadows using their mobile devices. Skincare producers are using similar technologies to track and predict the effects of serums and creams on various skin types. And brands like L’Oréal’s Lancôme are using facial analysis to read consumers’ skin tones to create personalized foundations.

“The more we’re able to use these tools like augmented reality [and] artificial intelligence to provide new consumer experiences, the more we can move to customizing and personalizing products for every consumer around the world, no matter what their skin tone is, no matter where they live, no matter who they are,” says Guive Balooch, global vice-president of L’Oréal’s technology incubator.

Balooch was tasked with starting up the company’s tech research hub four years ago, with a mandate to predict and invent solutions to how consumers would choose and use products in the future. Among its innovations, his team has come up with the Makeup Genius app, a virtual mirror that allows customers to try on products on a mobile screen, and a device called My UV Patch, a sticker sensor that users wear on their skin, which informs them through an app how much UV exposure they get.

These tools may seem easy enough to use, but their simplicity belies the work that goes on behind the scenes. To create the Makeup Genius app, for example, Balooch says the developers sought expertise from the animation industry to enable users to see themselves move onscreen in real time. The developers also brought in hundreds of consumers with different skin tones to test real products in the lab, and they tested the app on some 100,000 images in more than 40 lighting conditions, to ensure the colours of makeup products appeared the same in real life as they did onscreen, Balooch says.

The article is well worth reading in its entirety.

For the seriously curious, you can find Beauty AI here, In Silico Medicine here, and Imagene Labs here. I cannot find a website for Youth Laboratories featuring Anastasia Georgievskaya.

I last wrote about In Silico Medicine in a May 31, 2016 post about deep learning, wrinkles, and aging.

Oil spill cleanups with supergelators

Researchers in Singapore have proposed a new technology for cleaning up oil spills, according to a June 17, 2016 news item on Nanowerk,

Large-scale oil spills, where hundreds of tons of petroleum products are accidentally released into the oceans, not only have devastating effects on the environment, but have significant socio-economic impact as well [1].

Current techniques of cleaning up oil spills are not very efficient and may even cause further pollution or damage to the environment. These methods, which include the use of toxic detergent-like compounds called dispersants or burning of the oil slick, result in incomplete removal of the oil. The oil molecules remain in the water over long periods and may even be spread over a larger area as they are carried by wind and waves. Further, burning can only be applied to fresh oil slicks of at least 3 millimeters thick, and this process would also cause secondary environmental pollution.

In a bid to improve the technology utilized by cleanup crews to manage and contain such large spills, researchers from the Institute of Bioengineering and Nanotechnology (IBN) of A*STAR [located in Singapore] have invented a smart oil-scavenging material or supergelators that could help clean up oil spills efficiently and rapidly to prevent secondary pollution.

These supergelators are derived from highly soluble small organic molecules, which instantly self-assemble into nanofibers to form a 3D net that traps the oil molecules so that they can be removed easily from the surface of the water.

A June 17, 2016 IBN A*STAR media release, which originated the news item, provides more detail,

“Marine oil spills have a disastrous impact on the environment and marine life, and result in an enormous economic burden on society. Our rapid-acting supergelators offer an effective cleanup solution that can help to contain the severe environmental damage and impact of such incidents in the future,” said IBN Executive Director Professor Jackie Y. Ying.

Motivated by the urgent need for a more effective oil spill control solution, the IBN researchers developed new compounds that dissolve easily in environmentally friendly solvents and gel rapidly upon contact with oil. The supergelator molecules arrange themselves into a 3D network, entangling the oil molecules into clumps that can then be easily skimmed off the water’s surface.

“The most interesting and useful characteristic of our molecules is their ability to stack themselves on top of each other. These stacked columns allow our researchers to create and test different molecular constructions, while finding the best structure that will yield the desired properties,” said IBN Team Leader and Principal Research Scientist Dr Huaqiang Zeng. (Animation: Click to see how the supergelators stack themselves into columns.)

IBN’s supergelators have been tested on various types of weathered and unweathered crude oil in seawater, and have been found to be effective in solidifying all of them. The supergelators take only minutes to solidify the oil at room temperature for easy removal from water. In addition, tests carried out by the research team showed that the supergelator was not toxic to human cells, as well as zebrafish embryos and larvae. The researchers believe that these qualities would make the supergelators suitable for use in large oil spill areas.

The Institute is looking for industrial partners to further develop its technology for commercial use. [emphasis mine]

Video: Click to watch the supergelators in action

  1. The well documented BP Gulf of Mexico oil well accident in 2010 was a catastrophe on an unprecedented scale, with damages amounting to hundreds of billions of dollars. Its wide-ranging effects on the marine ecosystem, as well as the fishing and tourism industries, can still be felt six years on.

Here’s a link to and a citation for the paper,

Instant Room-Temperature Gelation of Crude Oil by Chiral Organogelators by Changliang Ren, Grace Hwee Boon Ng, Hong Wu, Kiat-Hwa Chan, Jie Shen, Cathleen Teh, Jackie Y. Ying, and Huaqiang Zeng. Chem. Mater., 2016, 28 (11), pp 4001–4008 DOI: 10.1021/acs.chemmater.6b01367 Publication Date (Web): May 10, 2016

Copyright © 2016 American Chemical Society

This paper is behind a paywall.

I have featured other nanotechnology-enabled oil spill cleanup solutions here. One of the more recent pieces is my Dec. 7, 2015 post about boron nitride sponges. The search terms: ‘oil spill’ and ‘oil spill cleanup’ will help you unearth more.

There have been some promising possibilities and I hope one day these clean up technologies will be brought to market.

Testing technology for a global quantum network

This work on quantum networks comes from a joint Singapore/UK research project, from a June 2, 2016 news item on ScienceDaily,

You can’t sign up for the quantum internet just yet, but researchers have reported a major experimental milestone towards building a global quantum network — and it’s happening in space.

With a network that carries information in the quantum properties of single particles, you can create secure keys for secret messaging and potentially connect powerful quantum computers in the future. But scientists think you will need equipment in space to get global reach.

Researchers from the National University of Singapore (NUS) and the University of Strathclyde, UK, have become the first to test in orbit technology for satellite-based quantum network nodes.

They have put a compact device carrying components used in quantum communication and computing into orbit. And it works: the team report first data in a paper published 31 May 2016 in the journal Physical Review Applied.

A June 2, 2016 National University of Singapore press release, which originated the news item, provides more detail,

The team’s device, dubbed SPEQS, creates and measures pairs of light particles, called photons. Results from space show that SPEQS is making pairs of photons with correlated properties – an indicator of performance.

Team-leader Alexander Ling, an Assistant Professor at the Centre for Quantum Technologies (CQT) at NUS said, “This is the first time anyone has tested this kind of quantum technology in space.”

The team had to be inventive to redesign a delicate, table-top quantum setup to be small and robust enough to fly inside a nanosatellite only the size of a shoebox. The whole satellite weighs just 1.65-kilogramme.

Towards entanglement

Making correlated photons is a precursor to creating entangled photons. Described by Einstein as “spooky action at a distance”, entanglement is a connection between quantum particles that lends security to communication and power to computing.

Professor Artur Ekert, Director of CQT, invented the idea of using entangled particles for cryptography. He said, “Alex and his team are taking entanglement, literally, to a new level. Their experiments will pave the road to secure quantum communication and distributed quantum computation on a global scale. I am happy to see that Singapore is one of the world leaders in this area.”

Local quantum networks already exist [emphasis mine]. The problem Ling’s team aims to solve is a distance limit. Losses limit quantum signals sent through air at ground level or optical fibre to a few hundred kilometers – but we might ultimately use entangled photons beamed from satellites to connect points on opposite sides of the planet. Although photons from satellites still have to travel through the atmosphere, going top-to-bottom is roughly equivalent to going only 10 kilometres at ground level.

The group’s first device is a technology pathfinder. It takes photons from a BluRay laser and splits them into two, then measures the pair’s properties, all on board the satellite. To do this it contains a laser diode, crystals, mirrors and photon detectors carefully aligned inside an aluminum block. This sits on top of a 10 centimetres by 10 centimetres printed circuit board packed with control electronics.

Through a series of pre-launch tests – and one unfortunate incident – the team became more confident that their design could survive a rocket launch and space conditions. The team had a device in the October 2014 Orbital-3 rocket which exploded on the launch pad. The satellite containing that first device was later found on a beach intact and still in working order.

Future plans

Even with the success of the more recent mission, a global network is still a few milestones away. The team’s roadmap calls for a series of launches, with the next space-bound SPEQS slated to produce entangled photons. SPEQS stands for Small Photon-Entangling Quantum System.

With later satellites, the researchers will try sending entangled photons to Earth and to other satellites. The team are working with standard “CubeSat” nanosatellites, which can get relatively cheap rides into space as rocket ballast. Ultimately, completing a global network would mean having a fleet of satellites in orbit and an array of ground stations.

In the meantime, quantum satellites could also carry out fundamental experiments – for example, testing entanglement over distances bigger than Earth-bound scientists can manage. “We are reaching the limits of how precisely we can test quantum theory on Earth,” said co-author Dr Daniel Oi at the University of Strathclyde.

Here’s a link to and a citation for the paper,

Generation and Analysis of Correlated Pairs of Photons aboard a Nanosatellite by Zhongkan Tang, Rakhitha Chandrasekara, Yue Chuan Tan, Cliff Cheng, Luo Sha, Goh Cher Hiang, Daniel K. L. Oi, and Alexander Ling. Phys. Rev. Applied 5, 054022 DOI: http://dx.doi.org/10.1103/PhysRevApplied.5.054022 Published 31 May 2016

This paper is behind a paywall.

An atom without properties?

There’s rather intriguing Swiss research into atoms and so-called Bell Correlations according to an April 21, 2016 news item on ScienceDaily,

The microscopic world is governed by the rules of quantum mechanics, where the properties of a particle can be completely undetermined and yet strongly correlated with those of other particles. Physicists from the University of Basel have observed these so-called Bell correlations for the first time between hundreds of atoms. Their findings are published in the scientific journal Science.

Everyday objects possess properties independently of each other and regardless of whether we observe them or not. Einstein famously asked whether the moon still exists if no one is there to look at it; we answer with a resounding yes. This apparent certainty does not exist in the realm of small particles. The location, speed or magnetic moment of an atom can be entirely indeterminate and yet still depend greatly on the measurements of other distant atoms.

An April 21, 2016 University of Basel (Switzerland) press release (also on EurekAlert), which originated the news item, provides further explanation,

With the (false) assumption that atoms possess their properties independently of measurements and independently of each other, a so-called Bell inequality can be derived. If it is violated by the results of an experiment, it follows that the properties of the atoms must be interdependent. This is described as Bell correlations between atoms, which also imply that each atom takes on its properties only at the moment of the measurement. Before the measurement, these properties are not only unknown – they do not even exist.

A team of researchers led by professors Nicolas Sangouard and Philipp Treutlein from the University of Basel, along with colleagues from Singapore, have now observed these Bell correlations for the first time in a relatively large system, specifically among 480 atoms in a Bose-Einstein condensate. Earlier experiments showed Bell correlations with a maximum of four light particles or 14 atoms. The results mean that these peculiar quantum effects may also play a role in larger systems.

Large number of interacting particles

In order to observe Bell correlations in systems consisting of many particles, the researchers first had to develop a new method that does not require measuring each particle individually – which would require a level of control beyond what is currently possible. The team succeeded in this task with the help of a Bell inequality that was only recently discovered. The Basel researchers tested their method in the lab with small clouds of ultracold atoms cooled with laser light down to a few billionths of a degree above absolute zero. The atoms in the cloud constantly collide, causing their magnetic moments to become slowly entangled. When this entanglement reaches a certain magnitude, Bell correlations can be detected. Author Roman Schmied explains: “One would expect that random collisions simply cause disorder. Instead, the quantum-mechanical properties become entangled so strongly that they violate classical statistics.”

More specifically, each atom is first brought into a quantum superposition of two states. After the atoms have become entangled through collisions, researchers count how many of the atoms are actually in each of the two states. This division varies randomly between trials. If these variations fall below a certain threshold, it appears as if the atoms have ‘agreed’ on their measurement results; this agreement describes precisely the Bell correlations.

New scientific territory

The work presented, which was funded by the National Centre of Competence in Research Quantum Science and Technology (NCCR QSIT), may open up new possibilities in quantum technology; for example, for generating random numbers or for quantum-secure data transmission. New prospects in basic research open up as well: “Bell correlations in many-particle systems are a largely unexplored field with many open questions – we are entering uncharted territory with our experiments,” says Philipp Treutlein.

Here’s a link to and a citation for the paper,

Bell correlations in a Bose-Einstein condensate by Roman Schmied, Jean-Daniel Bancal, Baptiste Allard, Matteo Fadel, Valerio Scarani, Philipp Treutlein, Nicolas Sangouard. Science  22 Apr 2016: Vol. 352, Issue 6284, pp. 441-444 DOI: 10.1126/science.aad8665

This paper is behind a paywall.

Artificial intelligence used for wildlife protection

PAWS (Protection Assistant for Wildlife Security), an artificial intelligence (AI) program, has been tested in Uganda and Malaysia. according to an April 22, 2016 US National Science Foundation (NSF) news release (also on EurekAlert but dated April 21, 2016), Note: Links have been removed,

A century ago, more than 60,000 tigers roamed the wild. Today, the worldwide estimate has dwindled to around 3,200. Poaching is one of the main drivers of this precipitous drop. Whether killed for skins, medicine or trophy hunting, humans have pushed tigers to near-extinction. The same applies to other large animal species like elephants and rhinoceros that play unique and crucial roles in the ecosystems where they live.

Human patrols serve as the most direct form of protection of endangered animals, especially in large national parks. However, protection agencies have limited resources for patrols.

With support from the National Science Foundation (NSF) and the Army Research Office, researchers are using artificial intelligence (AI) and game theory to solve poaching, illegal logging and other problems worldwide, in collaboration with researchers and conservationists in the U.S., Singapore, Netherlands and Malaysia.

“In most parks, ranger patrols are poorly planned, reactive rather than pro-active, and habitual,” according to Fei Fang, a Ph.D. candidate in the computer science department at the University of Southern California (USC).

Fang is part of an NSF-funded team at USC led by Milind Tambe, professor of computer science and industrial and systems engineering and director of the Teamcore Research Group on Agents and Multiagent Systems.

Their research builds on the idea of “green security games” — the application of game theory to wildlife protection. Game theory uses mathematical and computer models of conflict and cooperation between rational decision-makers to predict the behavior of adversaries and plan optimal approaches for containment. The Coast Guard and Transportation Security Administration have used similar methods developed by Tambe and others to protect airports and waterways.

“This research is a step in demonstrating that AI can have a really significant positive impact on society and allow us to assist humanity in solving some of the major challenges we face,” Tambe said.

PAWS puts the claws in anti-poaching

The team presented papers describing how they use their methods to improve the success of human patrols around the world at the AAAI Conference on Artificial Intelligence in February [2016].

The researchers first created an AI-driven application called PAWS (Protection Assistant for Wildlife Security) in 2013 and tested the application in Uganda and Malaysia in 2014. Pilot implementations of PAWS revealed some limitations, but also led to significant improvements.

Here’s a video describing the issues and PAWS,

For those who prefer to read about details rather listen, there’s more from the news release,

PAWS uses data on past patrols and evidence of poaching. As it receives more data, the system “learns” and improves its patrol planning. Already, the system has led to more observations of poacher activities per kilometer.

Its key technical advance lies in its ability to incorporate complex terrain information, including the topography of protected areas. That results in practical patrol routes that minimize elevation changes, saving time and energy. Moreover, the system can also take into account the natural transit paths that have the most animal traffic – and thus the most poaching – creating a “street map” for patrols.

“We need to provide actual patrol routes that can be practically followed,” Fang said. “These routes need to go back to a base camp and the patrols can’t be too long. We list all possible patrol routes and then determine which is most effective.”

The application also randomizes patrols to avoid falling into predictable patterns.

“If the poachers observe that patrols go to some areas more often than others, then the poachers place their snares elsewhere,” Fang said.

Since 2015, two non-governmental organizations, Panthera and Rimbat, have used PAWS to protect forests in Malaysia. The research won the Innovative Applications of Artificial Intelligence award for deployed application, as one of the best AI applications with measurable benefits.

The team recently combined PAWS with a new tool called CAPTURE (Comprehensive Anti-Poaching Tool with Temporal and Observation Uncertainty Reasoning) that predicts attacking probability even more accurately.

In addition to helping patrols find poachers, the tools may assist them with intercepting trafficked wildlife products and other high-risk cargo, adding another layer to wildlife protection. The researchers are in conversations with wildlife authorities in Uganda to deploy the system later this year. They will present their findings at the 15th International Conference on Autonomous Agents and Multiagent Systems (AAMAS 2016) in May.

“There is an urgent need to protect the natural resources and wildlife on our beautiful planet, and we computer scientists can help in various ways,” Fang said. “Our work on PAWS addresses one facet of the problem, improving the efficiency of patrols to combat poaching.”

There is yet another potential use for PAWS, the prevention of illegal logging,

While Fang and her colleagues work to develop effective anti-poaching patrol planning systems, other members of the USC team are developing complementary methods to prevent illegal logging, a major economic and environmental problem for many developing countries.

The World Wildlife Fund estimates trade in illegally harvested timber to be worth between $30 billion and $100 billion annually. The practice also threatens ancient forests and critical habitats for wildlife.

Researchers at USC, the University of Texas at El Paso and Michigan State University recently partnered with the non-profit organization Alliance Vohoary Gasy to limit the illegal logging of rosewood and ebony trees in Madagascar, which has caused a loss of forest cover on the island nation.

Forest protection agencies also face limited budgets and must cover large areas, making sound investments in security resources critical.

The research team worked to determine the balance of security resources in which Madagascar should invest to maximize protection, and to figure out how to best deploy those resources.

Past work in game theory-based security typically involved specified teams — the security workers assigned to airport checkpoints, for example, or the air marshals deployed on flight tours. Finding optimal security solutions for those scenarios is difficult; a solution involving an open-ended team had not previously been feasible.

To solve this problem, the researchers developed a new method called SORT (Simultaneous Optimization of Resource Teams) that they have been experimentally validating using real data from Madagascar.

The research team created maps of the national parks, modeled the costs of all possible security resources using local salaries and budgets, and computed the best combination of resources given these conditions.

“We compared the value of using an optimal team determined by our algorithm versus a randomly chosen team and the algorithm did significantly better,” said Sara Mc Carthy, a Ph.D. student in computer science at USC.

The algorithm is simple and fast, and can be generalized to other national parks with different characteristics. The team is working to deploy it in Madagascar in association with the Alliance Vohoary Gasy.

“I am very proud of what my PhD students Fei Fang and Sara Mc Carthy have accomplished in this research on AI for wildlife security and forest protection,” said Tambe, the team lead. “Interdisciplinary collaboration with practitioners in the field was key in this research and allowed us to improve our research in artificial intelligence.”

Moreover, the project shows other computer science researchers the potential impact of applying their research to the world’s problems.

“This work is not only important because of the direct beneficial impact that it has on the environment, protecting wildlife and forests, but on the way that it can inspire other to dedicate their efforts into making the world a better place,” Mc Carthy said.

The curious can find out more about Panthera here and about Alliance Vohoary Gasy here (be prepared to use your French language skills). Unfortunately, I could not find more information about Rimbat.

Sinagpore’s new chip could make low-powered wireless neural implants a possibility and Australians develop their own neural implant


This research from Singapore could make neuroprosthetics and exoskeletons a little easier to manage as long as you don’t mind having a neural implant. From a Feb. 11, 2016 news item on ScienceDaily,

A versatile chip offers multiple applications in various electronic devices, report researchers, suggested that there is now hope that a low-powered, wireless neural implant may soon be a reality. Neural implants when embedded in the brain can alleviate the debilitating symptoms of Parkinson’s disease or give paraplegic people the ability to move their prosthetic limbs.

Caption: NTU Asst Prof Arindam Basu is holding his low-powered smart chip. Credit: NTU Singapore

Caption: NTU Asst Prof Arindam Basu is holding his low-powered smart chip. Credit: NTU Singapore

A Feb. 11, 2016 Nanyang Technological University (NTU) press release (also on EurekAlert), which originated the news item, provides more detail,

Scientists at Nanyang Technological University, Singapore (NTU Singapore) have developed a small smart chip that can be paired with neural implants for efficient wireless transmission of brain signals.

Neural implants when embedded in the brain can alleviate the debilitating symptoms of Parkinson’s disease or give paraplegic people the ability to move their prosthetic limbs.

However, they need to be connected by wires to an external device outside the body. For a prosthetic patient, the neural implant is connected to a computer that decodes the brain signals so the artificial limb can move.

These external wires are not only cumbersome but the permanent openings which allow the wires into the brain increases the risk of infections.

The new chip by NTU scientists can allow the transmission of brain data wirelessly and with high accuracy.

Assistant Professor Arindam Basu from NTU’s School of Electrical and Electronic Engineering said the research team have tested the chip on data recorded from animal models, which showed that it could decode the brain’s signal to the hand and fingers with 95 per cent accuracy.

“What we have developed is a very versatile smart chip that can process data, analyse patterns and spot the difference,” explained Prof Basu.

“It is about a hundred times more efficient than current processing chips on the market. It will lead to more compact medical wearable devices, such as portable ECG monitoring devices and neural implants, since we no longer need large batteries to power them.”

Different from other wireless implants

To achieve high accuracy in decoding brain signals, implants require thousands of channels of raw data. To wirelessly transmit this large amount of data, more power is also needed which means either bigger batteries or more frequent recharging.

This is not feasible as there is limited space in the brain for implants while frequent recharging means the implants cannot be used for long-term recording of signals.

Current wireless implant prototypes thus suffer from a lack of accuracy as they lack the bandwidth to send out thousands of channels of raw data.

Instead of enlarging the power source to support the transmission of raw data, Asst Prof Basu tried to reduce the amount of data that needs to be transmitted.

Designed to be extremely power-efficient, NTU’s patented smart chip will analyse and decode the thousands of signals from the neural implants in the brain, before compressing the results and sending it wirelessly to a small external receiver.

This invention and its findings were published last month [December 2015] in the prestigious journal, IEEE Transactions on Biomedical Circuits & Systems, by the Institute of Electrical and Electronics Engineers, the world’s largest professional association for the advancement of technology.

Its underlying science was also featured in three international engineering conferences (two in Atlanta, USA and one in China) over the last three months.

Versatile smart chip with multiple uses

This new smart chip is designed to analyse data patterns and spot any abnormal or unusual patterns.

For example, in a remote video camera, the chip can be programmed to send a video back to the servers only when a specific type of car or something out of the ordinary is detected, such as an intruder.

This would be extremely beneficial for the Internet of Things (IOT), where every electrical and electronic device is connected to the Internet through a smart chip.

With a report by marketing research firm Gartner Inc predicting that 6.4 billion smart devices and appliances will be connected to the Internet by 2016, and will rise to 20.8 billion devices by 2020, reducing network traffic will be a priority for most companies.

Using NTU’s new chip, the devices can process and analyse the data on site, before sending back important details in a compressed package, instead of sending the whole data stream. This will reduce data usage by over a thousand times.

Asst Prof Basu is now in talks with Singapore Technologies Electronics Limited to adapt his smart chip that can significantly reduce power consumption and the amount of data transmitted by battery-operated remote sensors, such as video cameras.

The team is also looking to expand the applications of the chip into commercial products, such as to customise it for smart home sensor networks, in collaboration with a local electronics company.

The chip, measuring 5mm by 5mm can now be licensed by companies from NTU’s commercialisation arm, NTUitive.

Here’s a link to and a citation for the paper,

A 128-Channel Extreme Learning Machine-Based Neural Decoder for Brain Machine Interfaces by Yi Chen, Enyi Yao, Arindam Basu. IEEE Transactions on Biomedical Circuits and Systems, 2015; 1 DOI: 10.1109/TBCAS.2015.2483618

This paper is behind a paywall.


Earlier this month there was a Feb. 9, 2016 announcement about a planned human clinical trial in Australia for a new brain-machine interface (neural implant). Before proceeding with the news, here’s what this implant looks like,

Caption: This tiny device, the size of a small paperclip, is implanted in to a blood vessel next to the brain and can read electrical signals from the motor cortex, the brain's control centre. These signals can then be transmitted to an exoskeleton or wheelchair to give paraplegic patients greater mobility. Users will need to learn how to communicate with their machinery, but over time, it is thought it will become second nature, like driving or playing the piano. The first human trials are slated for 2017 in Melbourne, Australia. Credit: The University of Melbourne.

Caption: This tiny device, the size of a small paperclip, is implanted in to a blood vessel next to the brain and can read electrical signals from the motor cortex, the brain’s control centre. These signals can then be transmitted to an exoskeleton or wheelchair to give paraplegic patients greater mobility. Users will need to learn how to communicate with their machinery, but over time, it is thought it will become second nature, like driving or playing the piano. The first human trials are slated for 2017 in Melbourne, Australia. Credit: The University of Melbourne.

A Feb. 9, 2016 University of Melbourne press release (also on EurekAlert), which originated the news item, provides more detail,

Melbourne medical researchers have created a new minimally invasive brain-machine interface, giving people with spinal cord injuries new hope to walk again with the power of thought.

The brain machine interface consists of a stent-based electrode (stentrode), which is implanted within a blood vessel next to the brain, and records the type of neural activity that has been shown in pre-clinical trials to move limbs through an exoskeleton or to control bionic limbs.

The new device is the size of a small paperclip and will be implanted in the first in-human trial at The Royal Melbourne Hospital in 2017.

The results published today in Nature Biotechnology show the device is capable of recording high-quality signals emitted from the brain’s motor cortex, without the need for open brain surgery.

Principal author and Neurologist at The Royal Melbourne Hospital and Research Fellow at The Florey Institute of Neurosciences and the University of Melbourne, Dr Thomas Oxley, said the stentrode was revolutionary.

“The development of the stentrode has brought together leaders in medical research from The Royal Melbourne Hospital, The University of Melbourne and the Florey Institute of Neuroscience and Mental Health. In total 39 academic scientists from 16 departments were involved in its development,” Dr Oxley said.

“We have been able to create the world’s only minimally invasive device that is implanted into a blood vessel in the brain via a simple day procedure, avoiding the need for high risk open brain surgery.

“Our vision, through this device, is to return function and mobility to patients with complete paralysis by recording brain activity and converting the acquired signals into electrical commands, which in turn would lead to movement of the limbs through a mobility assist device like an exoskeleton. In essence this a bionic spinal cord.”

Stroke and spinal cord injuries are leading causes of disability, affecting 1 in 50 people. There are 20,000 Australians with spinal cord injuries, with the typical patient a 19-year old male, and about 150,000 Australians left severely disabled after stroke.

Co-principal investigator and biomedical engineer at the University of Melbourne, Dr Nicholas Opie, said the concept was similar to an implantable cardiac pacemaker – electrical interaction with tissue using sensors inserted into a vein, but inside the brain.

“Utilising stent technology, our electrode array self-expands to stick to the inside wall of a vein, enabling us to record local brain activity. By extracting the recorded neural signals, we can use these as commands to control wheelchairs, exoskeletons, prosthetic limbs or computers,” Dr Opie said.

“In our first-in-human trial, that we anticipate will begin within two years, we are hoping to achieve direct brain control of an exoskeleton for three people with paralysis.”

“Currently, exoskeletons are controlled by manual manipulation of a joystick to switch between the various elements of walking – stand, start, stop, turn. The stentrode will be the first device that enables direct thought control of these devices”

Neurophysiologist at The Florey, Professor Clive May, said the data from the pre-clinical study highlighted that the implantation of the device was safe for long-term use.

“Through our pre-clinical study we were able to successfully record brain activity over many months. The quality of recording improved as the device was incorporated into tissue,” Professor May said.

“Our study also showed that it was safe and effective to implant the device via angiography, which is minimally invasive compared with the high risks associated with open brain surgery.

“The brain-computer interface is a revolutionary device that holds the potential to overcome paralysis, by returning mobility and independence to patients affected by various conditions.”

Professor Terry O’Brien, Head of Medicine at Departments of Medicine and Neurology, The Royal Melbourne Hospital and University of Melbourne said the development of the stentrode has been the “holy grail” for research in bionics.

“To be able to create a device that can record brainwave activity over long periods of time, without damaging the brain is an amazing development in modern medicine,” Professor O’Brien said.

“It can also be potentially used in people with a range of diseases aside from spinal cord injury, including epilepsy, Parkinsons and other neurological disorders.”

The development of the minimally invasive stentrode and the subsequent pre-clinical trials to prove its effectiveness could not have been possible without the support from the major funding partners – US Defense Department DARPA [Defense Advanced Research Projects Agency] and Australia’s National Health and Medical Research Council.

So, DARPA is helping fund this, eh? Interesting but not a surprise given the agency’s previous investments in brain research and neuroprosthetics.

For those who like to get their news via video,

Here’s a link to and a citation for the paper,

Minimally invasive endovascular stent-electrode array for high-fidelity, chronic recordings of cortical neural activity by Thomas J Oxley, Nicholas L Opie, Sam E John, Gil S Rind, Stephen M Ronayne, Tracey L Wheeler, Jack W Judy, Alan J McDonald, Anthony Dornom, Timothy J H Lovell, Christopher Steward, David J Garrett, Bradford A Moffat, Elaine H Lui, Nawaf Yassi, Bruce C V Campbell, Yan T Wong, Kate E Fox, Ewan S Nurse, Iwan E Bennett, Sébastien H Bauquier, Kishan A Liyanage, Nicole R van der Nagel, Piero Perucca, Arman Ahnood et al. Nature Biotechnology (2016)  doi:10.1038/nbt.3428 Published online 08 February 2016

This paper is behind a paywall.

I wish the researchers in Singapore, Australia, and elsewhere, good luck!

2015 Mustafa prize winners (two nanoscientists) announced

The $500,000US Mustafa Prize was started in 2013 according to the information on prize website’s homepage,

The Mustafa Prize is a top science and technology award granted to the top researchers and scientists of the Organization of Islamic Cooperation (OIC) member states biennially.

The Prize seeks to encourage education and research and is set to play the pioneering role in developing relations between science and technology institutions working in the OIC member countries.

It also aims to improve scientific relation between academics and researchers to facilitate the growth and perfection of science in the OIC member states.

The laureates in each section will be awarded 500,000 USD which is financed through the endowments made to the Prize. The winners will also be adorned with a special medal and certificate.

The Mustafa Prize started its job in 2013. The Policy making Council of the Prize which is tasked with supervising various procedures of the event is comprised of high-profile universities and academic centers of OIC member states.

The prize will be granted to the works which have improved the human life and have made tangible and cutting-edge innovations on the boundaries of science or have presented new scientific methodology.

The 2015 winners were announced in a Dec. 23, 2015 news item on merhnews.com,

Dr. Hossein Zohour, Chairman of the science committee of Mustafa Scientific Prize, has announced the laureates on Wednesday [Dec. 16, 2015].

According to the Public Relations Department of Mustafa (PBUH) Prize, Professor Jackie Y. Ying from Singapore and Professor Omar Yaghi from Jordan won the top science and technology award of the Islamic world.

Zohour cited that the Mustafa (PBUH) Prize is awarded in four categories including, Life Sciences and Medicine, Nanoscience and Nanotechnology, Information and Communication Technologies and Top Scientific Achievement in general fields. “In the first three categories, the nominees must be citizens of one of the 57 Islamic countries while in the fourth category the nominee must be Muslim but being citizen of an Islamic country is not mandatory,” he added.

Professor Jackie Y. Ying, CEO and faculty member of the Institute of Bioengineering and Nanotechnology of Singapore and Professor Omar Yaghi, president of Kavli Nano-energy Organization and faculty member of University of California, Berkeley are the laureates in the fields of Nano-biotechnology sciences and Nanoscience and Nanotechnology respectively.

Zohour continued, “Professor Ying is awarded in recognition of her efforts in development of ‘stimulus response systems in targeted delivery of drugs’ in the field of Nano-biotechnology.”

These systems are consisted of polymeric nanoparticles, which auto-regulate the release of insulin therapeutic depending on the blood glucose levels without the need for sampling. The technology was first developed in her knowledge-based company and now being commercialized in big pharmaceutical firms to be at the service of human health.

Professor Omar Yaghi, prominent Jordanian chemist, has also been selected for his extensive research in the field of metal-organic frameworks (MOFs) in the category of nanoscience and nanotechnology.

It’s worth noting that this [sic] MOFs have a wide range of applications in clean energy technologies, carbon dioxide capturing and hydrogen and methane storage systems due to their extremely high surface areas.

The Mustafa (PBUH) Prize Award Ceremony will take place on Friday December 25 [2015] at Vahdat Hall to honor the laureates.

Unfortunately, I’ve not profiled Dr. Yaghi’s work here. Dr. Ying has been mentioned a few times (a March 2, 2015 posting, a May 12, 2014 posting, and an Aug. 22, 2013 posting) but not for the work for which she is being honoured.

Congratulations to both Dr. Yaghi and Dr. Ying!