Tag Archives: Tokyo University of Science

Neuromorphic transistor with electric double layer

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it may be my imagination but it seems as if neuromorphic (brainlike) engineering research has really taken off in the last few years and, even with my lazy approach to finding articles, I’m having trouble keeping up.

This latest work comes from Japan according to an August 4, 2023 news item on Nanowerk, Note: A link has been removed,

A research team consisting of NIMS [National Institute for Materials Science] and the Tokyo University of Science has developed the fastest electric double layer transistor using a highly ion conductive ceramic thin film and a diamond thin film. This transistor may be used to develop energy-efficient, high-speed edge AI devices with a wide range of applications, including future event prediction and pattern recognition/determination in images (including facial recognition), voices and odors.

The research was published in Materials Today Advances (“Ultrafast-switching of an all-solid-state electric double layer transistor with a porous yttria-stabilized zirconia proton conductor and the application to neuromorphic computing”).

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A July 7, 2023 National Institute for Materials Science press release (also on EurekAlert but published August 3, 2023), which originated the news item, is arranged as a numbered list of points, the first point being the first paragraph in the news release/item,

2. An electric double layer transistor works as a switch using electrical resistance changes caused by the charge and discharge of an electric double layer formed at the interface between the electrolyte and semiconductor. Because this transistor is able to mimic the electrical response of human cerebral neurons (i.e., acting as a neuromorphic transistor), its use in AI devices is potentially promising. However, existing electric double layer transistors are slow in switching between on and off states. The typical transition time ranges from several hundreds of microseconds to 10 milliseconds. Development of faster electric double layer transistors is therefore desirable.

3. This research team developed an electric double layer transistor by depositing ceramic (yttria-stabilized porous zirconia thin film) and diamond thin films with a high degree of precision using a pulsed laser, forming an electric double layer at the ceramic/diamond interface. The zirconia thin film is able to adsorb large amounts of water into its nanopores and allow hydrogen ions from the water to readily migrate through it, enabling the electric double layer to be rapidly charged and discharged. This electric double layer effect enables the transistor to operate very quickly. The team actually measured the speed at which the transistor operates by applying pulsed voltage to it and found that it operates 8.5 times faster than existing electric double layer transistors, setting a new world record. The team also confirmed the ability of this transistor to convert input waveforms into many different output waveforms with precision—a prerequisite for transistors to be compatible with neuromorphic AI devices.

4. This research project produced a new ceramic thin film technology capable of rapidly charging and discharging an electric double layer several nanometers in thickness. This is a major achievement in efforts to create practical, high-speed, energy-efficient AI-assisted devices. These devices, in combination with various sensors (e.g., smart watches, surveillance cameras and audio sensors), are expected to offer useful tools in various industries, including medicine, disaster prevention, manufacturing and security.

Here’s a link to and a citation for the paper,

Ultrafast-switching of an all-solid-state electric double layer transistor with a porous yttria-stabilized zirconia proton conductor and the application to neuromorphic computing by Makoto Takayanagi, Daiki Nishioka, Takashi Tsuchiya, Masataka Imura, Yasuo Koide, Tohru Higuchi, and Kazuya Terabe. Materials Today Advances [June 16, 2023]; DOI : 10.1016/j.mtadv.2023.10039

This paper is open access.

Growing complex skin tissue—complete with hair follicles and sebaceous glands

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A laboratory in Japan has managed to grow complex skin tissue according to an April 2, 2016 RIKEN (Japan) press release (also on EurekAlert but dated April 1, 2016),

Using reprogrammed iPS cells, scientists from the RIKEN Center for Developmental Biology (CDB) in Japan have, along with collaborators from Tokyo University of Science and other Japanese institutions, successfully grown complex skin tissue–complete with hair follicles and sebaceous glands–in the laboratory. They were then able to implant these three-dimensional tissues into living mice, and the tissues formed proper connections with other organ systems such as nerves and muscle fibers. This work opens a path to creating functional skin transplants for burn and other patients who require new skin.

Research into bioengineered tissues has led to important achievements in recent years–with a number of different tissue types being created–but there are still obstacles to be overcome. In the area of skin tissue, epithelial cells have been successfully grown into implantable sheets, but they did not have the proper appendages–the oil-secreting and sweat glands–that would allow them to function as normal tissue.

To perform the work, published in Science Advances, the researchers took cells from mouse gums and used chemicals to transform them into stem cell-like iPS cells. In culture, the cells properly developed into what is called an embryoid body (EB)?a three-dimensional clump of cells that partially resembles the developing embryo in an actual body. The researchers created EBs from iPS cells using Wnt10b signaling and then implanted multiple EBs into immune-deficient mice, where they gradually changed into differentiated tissue, following the pattern of an actual embryo. Once the tissue had differentiated, the scientists transplanted them out of those mice and into the skin tissue of other mice, where the tissues developed normally as integumentary tissue?the tissue between the outer and inner skin that is responsible for much of the function of the skin in terms of hair shaft eruption and fat excretion. Critically, they also found that the implanted tissues made normal connections with the surrounding nerve and muscle tissues, allowing it to function normally.

One important key to the development was that treatment with Wnt10b, a signaling molecule, resulted in a larger number of hair follicles, making the bioengineered tissue closer to natural tissue.

According to Takashi Tsuji of the RIKEN Center for Developmental Biology, who led the study, “Up until now, artificial skin development has been hampered by the fact that the skin lacked the important organs, such as hair follicles and exocrine glands, which allow the skin to play its important role in regulation. With this new technique, we have successfully grown skin that replicates the function of normal tissue. We are coming ever closer to the dream of being able to recreate actual organs in the lab for transplantation, and also believe that tissue grown through this method could be used as an alternative to animal testing of chemicals.”

Here’s a link to and a citation for the paper,

Bioengineering a 3D integumentary organ system from iPS cells using an in vivo transplantation model by Ryoji Takagi, Junko Ishimaru, Ayaka Sugawara, Koh-ei Toyoshima, Kentaro Ishida, Miho Ogawa, Kei Sakakibara, Kyosuke Asakawa, Akitoshi Kashiwakura, Masamitsu Oshima, Ryohei Minamide, Akio Sato, Toshihiro Yoshitake, Akira Takeda, Hiroshi Egusa, and Takashi Tsuji. Science Advances  01 Apr 2016: Vol. 2, no. 4, e1500887 DOI: 10.1126/sciadv.1500887

This appears to be an open access paper.