Tag Archives: University of Leeds

The metaverse or not

The ‘metaverse’ seems to be everywhere these days (especially since Facebook has made a number of announcements bout theirs (more about that later in this posting).

At this point, the metaverse is very hyped up despite having been around for about 30 years. According to the Wikipedia timeline (see the Metaverse entry), the first one was a MOO in 1993 called ‘The Metaverse’. In any event, it seems like it might be a good time to see what’s changed since I dipped my toe into a metaverse (Second Life by Linden Labs) in 2007.

(For grammar buffs, I switched from definite article [the] to indefinite article [a] purposefully. In reading the various opinion pieces and announcements, it’s not always clear whether they’re talking about a single, overarching metaverse [the] replacing the single, overarching internet or whether there will be multiple metaverses, in which case [a].)

The hype/the buzz … call it what you will

This September 6, 2021 piece by Nick Pringle for Fast Company dates the beginning of the metaverse to a 1992 science fiction novel before launching into some typical marketing hype (for those who don’t know, hype is the short form for hyperbole; Note: Links have been removed),

The term metaverse was coined by American writer Neal Stephenson in his 1993 sci-fi hit Snow Crash. But what was far-flung fiction 30 years ago is now nearing reality. At Facebook’s most recent earnings call [June 2021], CEO Mark Zuckerberg announced the company’s vision to unify communities, creators, and commerce through virtual reality: “Our overarching goal across all of these initiatives is to help bring the metaverse to life.”

So what actually is the metaverse? It’s best explained as a collection of 3D worlds you explore as an avatar. Stephenson’s original vision depicted a digital 3D realm in which users interacted in a shared online environment. Set in the wake of a catastrophic global economic crash, the metaverse in Snow Crash emerged as the successor to the internet. Subcultures sprung up alongside new social hierarchies, with users expressing their status through the appearance of their digital avatars.

Today virtual worlds along these lines are formed, populated, and already generating serious money. Household names like Roblox and Fortnite are the most established spaces; however, there are many more emerging, such as Decentraland, Upland, Sandbox, and the soon to launch Victoria VR.

These metaverses [emphasis mine] are peaking at a time when reality itself feels dystopian, with a global pandemic, climate change, and economic uncertainty hanging over our daily lives. The pandemic in particular saw many of us escape reality into online worlds like Roblox and Fortnite. But these spaces have proven to be a place where human creativity can flourish amid crisis.

In fact, we are currently experiencing an explosion of platforms parallel to the dotcom boom. While many of these fledgling digital worlds will become what Ask Jeeves was to Google, I predict [emphasis mine] that a few will match the scale and reach of the tech giant—or even exceed it.

Because the metaverse brings a new dimension to the internet, brands and businesses will need to consider their current and future role within it. Some brands are already forging the way and establishing a new genre of marketing in the process: direct to avatar (D2A). Gucci sold a virtual bag for more than the real thing in Roblox; Nike dropped virtual Jordans in Fortnite; Coca-Cola launched avatar wearables in Decentraland, and Sotheby’s has an art gallery that your avatar can wander in your spare time.

D2A is being supercharged by blockchain technology and the advent of digital ownership via NFTs, or nonfungible tokens. NFTs are already making waves in art and gaming. More than $191 million was transacted on the “play to earn” blockchain game Axie Infinity in its first 30 days this year. This kind of growth makes NFTs hard for brands to ignore. In the process, blockchain and crypto are starting to feel less and less like “outsider tech.” There are still big barriers to be overcome—the UX of crypto being one, and the eye-watering environmental impact of mining being the other. I believe technology will find a way. History tends to agree.

Detractors see the metaverse as a pandemic fad, wrapping it up with the current NFT bubble or reducing it to Zuck’s [Jeffrey Zuckerberg and Facebook] dystopian corporate landscape. This misses the bigger behavior change that is happening among Gen Alpha. When you watch how they play, it becomes clear that the metaverse is more than a buzzword.

For Gen Alpha [emphasis mine], gaming is social life. While millennials relentlessly scroll feeds, Alphas and Zoomers [emphasis mine] increasingly stroll virtual spaces with their friends. Why spend the evening staring at Instagram when you can wander around a virtual Harajuku with your mates? If this seems ridiculous to you, ask any 13-year-old what they think.

Who is Nick Pringle and how accurate are his predictions?

At the end of his September 6, 2021 piece, you’ll find this,

Nick Pringle is SVP [Senior Vice President] executive creative director at R/GA London.

According to the R/GA Wikipedia entry,

… [the company] evolved from a computer-assisted film-making studio to a digital design and consulting company, as part of a major advertising network.

Here’s how Pringle sees our future, his September 6, 2021 piece,

By thinking “virtual first,” you can see how these spaces become highly experimental, creative, and valuable. The products you can design aren’t bound by physics or marketing convention—they can be anything, and are now directly “ownable” through blockchain. …

I believe that the metaverse is here to stay. That means brands and marketers now have the exciting opportunity to create products that exist in multiple realities. The winners will understand that the metaverse is not a copy of our world, and so we should not simply paste our products, experiences, and brands into it.

I emphasized “These metaverses …” in the previous section to highlight the fact that I find the use of ‘metaverses’ vs. ‘worlds’ confusing as the words are sometimes used as synonyms and sometimes as distinctions. We do it all the time in all sorts of conversations but for someone who’s an outsider to a particular occupational group or subculture, the shifts can make for confusion.

As for Gen Alpha and Zoomer, I’m not a fan of ‘Gen anything’ as shorthand for describing a cohort based on birth years. For example, “For Gen Alpha [emphasis mine], gaming is social life,” ignores social and economic classes, as well as, the importance of locations/geography, e.g., Afghanistan in contrast to the US.

To answer the question I asked, Pringle does not mention any record of accuracy for his predictions for the future but I was able to discover that he is a “multiple Cannes Lions award-winning creative” (more here).

A more measured view of the metaverse

An October 4, 2021 article (What is the metaverse, and do I have to care? One part definition, one part aspiration, one part hype) by Adi Robertson and Jay Peters for The Verge offers a deeper dive into the metaverse (Note: Links have been removed),

In recent months you may have heard about something called the metaverse. Maybe you’ve read that the metaverse is going to replace the internet. Maybe we’re all supposed to live there. Maybe Facebook (or Epic, or Roblox, or dozens of smaller companies) is trying to take it over. And maybe it’s got something to do with NFTs [non-fungible tokens]?

Unlike a lot of things The Verge covers, the metaverse is tough to explain for one reason: it doesn’t necessarily exist. It’s partly a dream for the future of the internet and partly a neat way to encapsulate some current trends in online infrastructure, including the growth of real-time 3D worlds.

Then what is the real metaverse?

There’s no universally accepted definition of a real “metaverse,” except maybe that it’s a fancier successor to the internet. Silicon Valley metaverse proponents sometimes reference a description from venture capitalist Matthew Ball, author of the extensive Metaverse Primer:

“The Metaverse is an expansive network of persistent, real-time rendered 3D worlds and simulations that support continuity of identity, objects, history, payments, and entitlements, and can be experienced synchronously by an effectively unlimited number of users, each with an individual sense of presence.”

Facebook, arguably the tech company with the biggest stake in the metaverse, describes it more simply:

“The ‘metaverse’ is a set of virtual spaces where you can create and explore with other people who aren’t in the same physical space as you.”

There are also broader metaverse-related taxonomies like one from game designer Raph Koster, who draws a distinction between “online worlds,” “multiverses,” and “metaverses.” To Koster, online worlds are digital spaces — from rich 3D environments to text-based ones — focused on one main theme. Multiverses are “multiple different worlds connected in a network, which do not have a shared theme or ruleset,” including Ready Player One’s OASIS. And a metaverse is “a multiverse which interoperates more with the real world,” incorporating things like augmented reality overlays, VR dressing rooms for real stores, and even apps like Google Maps.

If you want something a little snarkier and more impressionistic, you can cite digital scholar Janet Murray — who has described the modern metaverse ideal as “a magical Zoom meeting that has all the playful release of Animal Crossing.”

But wait, now Ready Player One isn’t a metaverse and virtual worlds don’t have to be 3D? It sounds like some of these definitions conflict with each other.

An astute observation.

Why is the term “metaverse” even useful? “The internet” already covers mobile apps, websites, and all kinds of infrastructure services. Can’t we roll virtual worlds in there, too?

Matthew Ball favors the term “metaverse” because it creates a clean break with the present-day internet. [emphasis mine] “Using the metaverse as a distinctive descriptor allows us to understand the enormity of that change and in turn, the opportunity for disruption,” he said in a phone interview with The Verge. “It’s much harder to say ‘we’re late-cycle into the last thing and want to change it.’ But I think understanding this next wave of computing and the internet allows us to be more proactive than reactive and think about the future as we want it to be, rather than how to marginally affect the present.”

A more cynical spin is that “metaverse” lets companies dodge negative baggage associated with “the internet” in general and social media in particular. “As long as you can make technology seem fresh and new and cool, you can avoid regulation,” researcher Joan Donovan told The Washington Post in a recent article about Facebook and the metaverse. “You can run defense on that for several years before the government can catch up.”

There’s also one very simple reason: it sounds more futuristic than “internet” and gets investors and media people (like us!) excited.

People keep saying NFTs are part of the metaverse. Why?

NFTs are complicated in their own right, and you can read more about them here. Loosely, the thinking goes: NFTs are a way of recording who owns a specific virtual good, creating and transferring virtual goods is a big part of the metaverse, thus NFTs are a potentially useful financial architecture for the metaverse. Or in more practical terms: if you buy a virtual shirt in Metaverse Platform A, NFTs can create a permanent receipt and let you redeem the same shirt in Metaverse Platforms B to Z.

Lots of NFT designers are selling collectible avatars like CryptoPunks, Cool Cats, and Bored Apes, sometimes for astronomical sums. Right now these are mostly 2D art used as social media profile pictures. But we’re already seeing some crossover with “metaverse”-style services. The company Polygonal Mind, for instance, is building a system called CryptoAvatars that lets people buy 3D avatars as NFTs and then use them across multiple virtual worlds.

If you have the time, the October 4, 2021 article (What is the metaverse, and do I have to care? One part definition, one part aspiration, one part hype) is definitely worth the read.

Facebook’s multiverse and other news

Since starting this post sometime in September 2021, the situation regarding Facebook has changed a few times. I’ve decided to begin my version of the story from a summer 2021 announcement.

On Monday, July 26, 2021, Facebook announced a new Metaverse product group. From a July 27, 2021 article by Scott Rosenberg for Yahoo News (Note: A link has been removed),

Facebook announced Monday it was forming a new Metaverse product group to advance its efforts to build a 3D social space using virtual and augmented reality tech.

Facebook’s new Metaverse product group will report to Andrew Bosworth, Facebook’s vice president of virtual and augmented reality [emphasis mine], who announced the new organization in a Facebook post.

Facebook, integrity, and safety in the metaverse

On September 27, 2021 Facebook posted this webpage (Building the Metaverse Responsibly by Andrew Bosworth, VP, Facebook Reality Labs [emphasis mine] and Nick Clegg, VP, Global Affairs) on its site,

The metaverse won’t be built overnight by a single company. We’ll collaborate with policymakers, experts and industry partners to bring this to life.

We’re announcing a $50 million investment in global research and program partners to ensure these products are developed responsibly.

We develop technology rooted in human connection that brings people together. As we focus on helping to build the next computing platform, our work across augmented and virtual reality and consumer hardware will deepen that human connection regardless of physical distance and without being tied to devices. 

Introducing the XR [extended reality] Programs and Research Fund

There’s a long road ahead. But as a starting point, we’re announcing the XR Programs and Research Fund, a two-year $50 million investment in programs and external research to help us in this effort. Through this fund, we’ll collaborate with industry partners, civil rights groups, governments, nonprofits and academic institutions to determine how to build these technologies responsibly. 

..

Where integrity and safety are concerned Facebook is once again having some credibility issues according to an October 5, 2021 Associated Press article (Whistleblower testifies Facebook chooses profit over safety, calls for ‘congressional action’) posted on the Canadian Broadcasting Corporation’s (CBC) news online website.

Rebranding Facebook’s integrity and safety issues away?

It seems Facebook’s credibility issues are such that the company is about to rebrand itself according to an October 19, 2021 article by Alex Heath for The Verge (Note: Links have been removed),

Facebook is planning to change its company name next week to reflect its focus on building the metaverse, according to a source with direct knowledge of the matter.

The coming name change, which CEO Mark Zuckerberg plans to talk about at the company’s annual Connect conference on October 28th [2021], but could unveil sooner, is meant to signal the tech giant’s ambition to be known for more than social media and all the ills that entail. The rebrand would likely position the blue Facebook app as one of many products under a parent company overseeing groups like Instagram, WhatsApp, Oculus, and more. A spokesperson for Facebook declined to comment for this story.

Facebook already has more than 10,000 employees building consumer hardware like AR glasses that Zuckerberg believes will eventually be as ubiquitous as smartphones. In July, he told The Verge that, over the next several years, “we will effectively transition from people seeing us as primarily being a social media company to being a metaverse company.”

A rebrand could also serve to further separate the futuristic work Zuckerberg is focused on from the intense scrutiny Facebook is currently under for the way its social platform operates today. A former employee turned whistleblower, Frances Haugen, recently leaked a trove of damning internal documents to The Wall Street Journal and testified about them before Congress. Antitrust regulators in the US and elsewhere are trying to break the company up, and public trust in how Facebook does business is falling.

Facebook isn’t the first well-known tech company to change its company name as its ambitions expand. In 2015, Google reorganized entirely under a holding company called Alphabet, partly to signal that it was no longer just a search engine, but a sprawling conglomerate with companies making driverless cars and health tech. And Snapchat rebranded to Snap Inc. in 2016, the same year it started calling itself a “camera company” and debuted its first pair of Spectacles camera glasses.

If you have time, do read Heath’s article in its entirety.

An October 20, 2021 Thomson Reuters item on CBC (Canadian Broadcasting Corporation) news online includes quotes from some industry analysts about the rebrand,

“It reflects the broadening out of the Facebook business. And then, secondly, I do think that Facebook’s brand is probably not the greatest given all of the events of the last three years or so,” internet analyst James Cordwell at Atlantic Equities said.

“Having a different parent brand will guard against having this negative association transferred into a new brand, or other brands that are in the portfolio,” said Shankha Basu, associate professor of marketing at University of Leeds.

Tyler Jadah’s October 20, 2021 article for the Daily Hive includes an earlier announcement (not mentioned in the other two articles about the rebranding), Note: A link has been removed,

Earlier this week [October 17, 2021], Facebook announced it will start “a journey to help build the next computing platform” and will hire 10,000 new high-skilled jobs within the European Union (EU) over the next five years.

“Working with others, we’re developing what is often referred to as the ‘metaverse’ — a new phase of interconnected virtual experiences using technologies like virtual and augmented reality,” wrote Facebook’s Nick Clegg, the VP of Global Affairs. “At its heart is the idea that by creating a greater sense of “virtual presence,” interacting online can become much closer to the experience of interacting in person.”

Clegg says the metaverse has the potential to help unlock access to new creative, social, and economic opportunities across the globe and the virtual world.

In an email with Facebook’s Corporate Communications Canada, David Troya-Alvarez told Daily Hive, “We don’t comment on rumour or speculation,” in regards to The Verge‘s report.

I will update this posting when and if Facebook rebrands itself into a ‘metaverse’ company.

***See Oct. 28, 2021 update at the end of this posting and prepare yourself for ‘Meta’.***

Who (else) cares about integrity and safety in the metaverse?

Apparently, the international legal firm, Norton Rose Fulbright also cares about safety and integrity in the metaverse. Here’s more from their July 2021 The Metaverse: The evolution of a universal digital platform webpage,

In technology, first-mover advantage is often significant. This is why BigTech and other online platforms are beginning to acquire software businesses to position themselves for the arrival of the Metaverse.  They hope to be at the forefront of profound changes that the Metaverse will bring in relation to digital interactions between people, between businesses, and between them both. 

What is the Metaverse? The short answer is that it does not exist yet. At the moment it is vision for what the future will be like where personal and commercial life is conducted digitally in parallel with our lives in the physical world. Sounds too much like science fiction? For something that does not exist yet, the Metaverse is drawing a huge amount of attention and investment in the tech sector and beyond.  

Here we look at what the Metaverse is, what its potential is for disruptive change, and some of the key legal and regulatory issues future stakeholders may need to consider.

What are the potential legal issues?

The revolutionary nature of the Metaverse is likely to give rise to a range of complex legal and regulatory issues. We consider some of the key ones below. As time goes by, naturally enough, new ones will emerge.

Data

Participation in the Metaverse will involve the collection of unprecedented amounts and types of personal data. Today, smartphone apps and websites allow organisations to understand how individuals move around the web or navigate an app. Tomorrow, in the Metaverse, organisations will be able to collect information about individuals’ physiological responses, their movements and potentially even brainwave patterns, thereby gauging a much deeper understanding of their customers’ thought processes and behaviours.

Users participating in the Metaverse will also be “logged in” for extended amounts of time. This will mean that patterns of behaviour will be continually monitored, enabling the Metaverse and the businesses (vendors of goods and services) participating in the Metaverse to understand how best to service the users in an incredibly targeted way.

The hungry Metaverse participant

How might actors in the Metaverse target persons participating in the Metaverse? Let us assume one such woman is hungry at the time of participating. The Metaverse may observe a woman frequently glancing at café and restaurant windows and stopping to look at cakes in a bakery window, and determine that she is hungry and serve her food adverts accordingly.

Contrast this with current technology, where a website or app can generally only ascertain this type of information if the woman actively searched for food outlets or similar on her device.

Therefore, in the Metaverse, a user will no longer need to proactively provide personal data by opening up their smartphone and accessing their webpage or app of choice. Instead, their data will be gathered in the background while they go about their virtual lives. 

This type of opportunity comes with great data protection responsibilities. Businesses developing, or participating in, the Metaverse will need to comply with data protection legislation when processing personal data in this new environment. The nature of the Metaverse raises a number of issues around how that compliance will be achieved in practice.

Who is responsible for complying with applicable data protection law? 

In many jurisdictions, data protection laws place different obligations on entities depending on whether an entity determines the purpose and means of processing personal data (referred to as a “controller” under the EU General Data Protection Regulation (GDPR)) or just processes personal data on behalf of others (referred to as a “processor” under the GDPR). 

In the Metaverse, establishing which entity or entities have responsibility for determining how and why personal data will be processed, and who processes personal data on behalf of another, may not be easy. It will likely involve picking apart a tangled web of relationships, and there may be no obvious or clear answers – for example:

Will there be one main administrator of the Metaverse who collects all personal data provided within it and determines how that personal data will be processed and shared?
Or will multiple entities collect personal data through the Metaverse and each determine their own purposes for doing so? 

Either way, many questions arise, including:

How should the different entities each display their own privacy notice to users? 
Or should this be done jointly? 
How and when should users’ consent be collected? 
Who is responsible if users’ personal data is stolen or misused while they are in the Metaverse? 
What data sharing arrangements need to be put in place and how will these be implemented?

There’s a lot more to this page including a look at Social Media Regulation and Intellectual Property Rights.

One other thing, according to the Norton Rose Fulbright Wikipedia entry, it is one of the ten largest legal firms in the world.

How many realities are there?

I’m starting to think we should talking about RR (real reality), as well as, VR (virtual reality), AR (augmented reality), MR (mixed reality), and XR (extended reality). It seems that all of these (except RR, which is implied) will be part of the ‘metaverse’, assuming that it ever comes into existence. Happily, I have found a good summarized description of VR/AR/MR/XR in a March 20, 2018 essay by North of 41 on medium.com,

Summary: VR is immersing people into a completely virtual environment; AR is creating an overlay of virtual content, but can’t interact with the environment; MR is a mixed of virtual reality and the reality, it creates virtual objects that can interact with the actual environment. XR brings all three Reality (AR, VR, MR) together under one term.

If you have the interest and approximately five spare minutes, read the entire March 20, 2018 essay, which has embedded images illustrating the various realities.

Alternate Mixed Realities: an example

TransforMR: Pose-Aware Object Substitution for Composing Alternate Mixed Realities (ISMAR ’21)

Here’s a description from one of the researchers, Mohamed Kari, of the video, which you can see above, and the paper he and his colleagues presented at the 20th IEEE International Symposium on Mixed and Augmented Reality (ISMAR), 2021 (from the TransforMR page on YouTube),

We present TransforMR, a video see-through mixed reality system for mobile devices that performs 3D-pose-aware object substitution to create meaningful mixed reality scenes in previously unseen, uncontrolled, and open-ended real-world environments.

To get a sense of how recent this work is, ISMAR 2021 was held from October 4 – 8, 2021.

The team’s 2021 ISMAR paper, TransforMR Pose-Aware Object Substitution for Composing Alternate Mixed Realities by Mohamed Kari, Tobias Grosse-Puppendah, Luis Falconeri Coelho, Andreas Rene Fender, David Bethge, Reinhard Schütte, and Christian Holz lists two educational institutions I’d expect to see (University of Duisburg-Essen and ETH Zürich), the surprise was this one: Porsche AG. Perhaps that explains the preponderance of vehicles in this demonstration.

Space walking in virtual reality

Ivan Semeniuk’s October 2, 2021 article for the Globe and Mail highlights a collaboration between Montreal’s Felix and Paul Studios with NASA (US National Aeronautics and Space Administration) and Time studios,

Communing with the infinite while floating high above the Earth is an experience that, so far, has been known to only a handful.

Now, a Montreal production company aims to share that experience with audiences around the world, following the first ever recording of a spacewalk in the medium of virtual reality.

The company, which specializes in creating virtual-reality experiences with cinematic flair, got its long-awaited chance in mid-September when astronauts Thomas Pesquet and Akihiko Hoshide ventured outside the International Space Station for about seven hours to install supports and other equipment in preparation for a new solar array.

The footage will be used in the fourth and final instalment of Space Explorers: The ISS Experience, a virtual-reality journey to space that has already garnered a Primetime Emmy Award for its first two episodes.

From the outset, the production was developed to reach audiences through a variety of platforms for 360-degree viewing, including 5G-enabled smart phones and tablets. A domed theatre version of the experience for group audiences opened this week at the Rio Tinto Alcan Montreal Planetarium. Those who desire a more immersive experience can now see the first two episodes in VR form by using a headset available through the gaming and entertainment company Oculus. Scenes from the VR series are also on offer as part of The Infinite, an interactive exhibition developed by Montreal’s Phi Studio, whose works focus on the intersection of art and technology. The exhibition, which runs until Nov. 7 [2021], has attracted 40,000 visitors since it opened in July [2021?].

At a time when billionaires are able to head off on private extraterrestrial sojourns that almost no one else could dream of, Lajeunesse [Félix Lajeunesse, co-founder and creative director of Felix and Paul studios] said his project was developed with a very different purpose in mind: making it easier for audiences to become eyewitnesses rather than distant spectators to humanity’s greatest adventure.

For the final instalments, the storyline takes viewers outside of the space station with cameras mounted on the Canadarm, and – for the climax of the series – by following astronauts during a spacewalk. These scenes required extensive planning, not only because of the limited time frame in which they could be gathered, but because of the lighting challenges presented by a constantly shifting sun as the space station circles the globe once every 90 minutes.

… Lajeunesse said that it was equally important to acquire shots that are not just technically spectacular but that serve the underlying themes of Space Explorers: The ISS Experience. These include an examination of human adaptation and advancement, and the unity that emerges within a group of individuals from many places and cultures and who must learn to co-exist in a high risk environment in order to achieve a common goal.

If you have the time, do read Semeniuk’s October 2, 2021 article in its entirety. You can find the exhibits (hopefully, you’re in Montreal) The Infinite here and Space Explorers: The ISS experience here (see the preview below),

The realities and the ‘verses

There always seems to be a lot of grappling with new and newish science/technology where people strive to coin terms and define them while everyone, including members of the corporate community, attempts to cash in.

The last time I looked (probably about two years ago), I wasn’t able to find any good definitions for alternate reality and mixed reality. (By good, I mean something which clearly explicated the difference between the two.) It was nice to find something this time.

As for Facebook and its attempts to join/create a/the metaverse, the company’s timing seems particularly fraught. As well, paradigm-shifting technology doesn’t usually start with large corporations. The company is ignoring its own history.

Multiverses

Writing this piece has reminded me of the upcoming movie, “Doctor Strange in the Multiverse of Madness” (Wikipedia entry). While this multiverse is based on a comic book, the idea of a Multiverse (Wikipedia entry) has been around for quite some time,

Early recorded examples of the idea of infinite worlds existed in the philosophy of Ancient Greek Atomism, which proposed that infinite parallel worlds arose from the collision of atoms. In the third century BCE, the philosopher Chrysippus suggested that the world eternally expired and regenerated, effectively suggesting the existence of multiple universes across time.[1] The concept of multiple universes became more defined in the Middle Ages.

Multiple universes have been hypothesized in cosmology, physics, astronomy, religion, philosophy, transpersonal psychology, music, and all kinds of literature, particularly in science fiction, comic books and fantasy. In these contexts, parallel universes are also called “alternate universes”, “quantum universes”, “interpenetrating dimensions”, “parallel universes”, “parallel dimensions”, “parallel worlds”, “parallel realities”, “quantum realities”, “alternate realities”, “alternate timelines”, “alternate dimensions” and “dimensional planes”.

The physics community has debated the various multiverse theories over time. Prominent physicists are divided about whether any other universes exist outside of our own.

Living in a computer simulation or base reality

The whole thing is getting a little confusing for me so I think I’ll stick with RR (real reality) or as it’s also known base reality. For the notion of base reality, I want to thank astronomer David Kipping of Columbia University in Anil Ananthaswamy’s article for this analysis of the idea that we might all be living in a computer simulation (from my December 8, 2020 posting; scroll down about 50% of the way to the “Are we living in a computer simulation?” subhead),

… there is a more obvious answer: Occam’s razor, which says that in the absence of other evidence, the simplest explanation is more likely to be correct. The simulation hypothesis is elaborate, presuming realities nested upon realities, as well as simulated entities that can never tell that they are inside a simulation. “Because it is such an overly complicated, elaborate model in the first place, by Occam’s razor, it really should be disfavored, compared to the simple natural explanation,” Kipping says.

Maybe we are living in base reality after all—The Matrix, Musk and weird quantum physics notwithstanding.

To sum it up (briefly)

I’m sticking with the base reality (or real reality) concept, which is where various people and companies are attempting to create a multiplicity of metaverses or the metaverse effectively replacing the internet. This metaverse can include any all of these realities (AR/MR/VR/XR) along with base reality. As for Facebook’s attempt to build ‘the metaverse’, it seems a little grandiose.

The computer simulation theory is an interesting thought experiment (just like the multiverse is an interesting thought experiment). I’ll leave them there.

Wherever it is we are living, these are interesting times.

***Updated October 28, 2021: D. (Devindra) Hardawar’s October 28, 2021 article for engadget offers details about the rebranding along with a dash of cynicism (Note: A link has been removed),

Here’s what Facebook’s metaverse isn’t: It’s not an alternative world to help us escape from our dystopian reality, a la Snow Crash. It won’t require VR or AR glasses (at least, not at first). And, most importantly, it’s not something Facebook wants to keep to itself. Instead, as Mark Zuckerberg described to media ahead of today’s Facebook Connect conference, the company is betting it’ll be the next major computing platform after the rise of smartphones and the mobile web. Facebook is so confident, in fact, Zuckerberg announced that it’s renaming itself to “Meta.”

After spending the last decade becoming obsessed with our phones and tablets — learning to stare down and scroll practically as a reflex — the Facebook founder thinks we’ll be spending more time looking up at the 3D objects floating around us in the digital realm. Or maybe you’ll be following a friend’s avatar as they wander around your living room as a hologram. It’s basically a digital world layered right on top of the real world, or an “embodied internet” as Zuckerberg describes.

Before he got into the weeds for his grand new vision, though, Zuckerberg also preempted criticism about looking into the future now, as the Facebook Papers paint the company as a mismanaged behemoth that constantly prioritizes profit over safety. While acknowledging the seriousness of the issues the company is facing, noting that it’ll continue to focus on solving them with “industry-leading” investments, Zuckerberg said: 

“The reality is is that there’s always going to be issues and for some people… they may have the view that there’s never really a great time to focus on the future… From my perspective, I think that we’re here to create things and we believe that we can do this and that technology can make things better. So we think it’s important to to push forward.”

Given the extent to which Facebook, and Zuckerberg in particular, have proven to be untrustworthy stewards of social technology, it’s almost laughable that the company wants us to buy into its future. But, like the rise of photo sharing and group chat apps, Zuckerberg at least has a good sense of what’s coming next. And for all of his talk of turning Facebook into a metaverse company, he’s adamant that he doesn’t want to build a metaverse that’s entirely owned by Facebook. He doesn’t think other companies will either. Like the mobile web, he thinks every major technology company will contribute something towards the metaverse. He’s just hoping to make Facebook a pioneer.

“Instead of looking at a screen, or today, how we look at the Internet, I think in the future you’re going to be in the experiences, and I think that’s just a qualitatively different experience,” Zuckerberg said. It’s not quite virtual reality as we think of it, and it’s not just augmented reality. But ultimately, he sees the metaverse as something that’ll help to deliver more presence for digital social experiences — the sense of being there, instead of just being trapped in a zoom window. And he expects there to be continuity across devices, so you’ll be able to start chatting with friends on your phone and seamlessly join them as a hologram when you slip on AR glasses.

D. (Devindra) Hardawar’s October 28, 2021 article provides a lot more details and I recommend reading it in its entirety.

Gold nanotubes for treating mesothelioma?

An October 26, 2020 news item on Nanowerk describes some new research that may lead the way to treatments for people with asbestos-related cancers (e.g., mesothelioma), Note: A link has been removed,

Gold nanotubes – tiny hollow cylinders one thousandth the width of a human hair – could be used to treat mesothelioma, a type of cancer caused by exposure to asbestos, according to a team of researchers at the Universities of Cambridge and Leeds.

In a study published in journal Small (“Exploring High Aspect Ratio Gold Nanotubes as Cytosolic Agents: Structural Engineering and Uptake into Mesothelioma Cells”), the researchers demonstrate that once inside the cancer cells, the nanotubes absorb light, causing them to heat up, thereby killing the cells.

Here`s an image illustrating the research,

Caption: Confocal fluorescence image of gold nanotures (green) in mesothelioma cells. Credit: Arsalan Azad

An October 27, 2020 University of Cambridge press release (also on EurekAlert but published on Oct. 26, 2020), which originated the news item, describes the context for the research and provides a few more technical details,

More than 2,600 people are diagnosed in the UK each year with mesothelioma, a malignant form of cancer caused by exposure to asbestos. Although the use of asbestos is outlawed in the UK now, the country has the world’s highest levels of mesothelioma because it imported vast amounts of asbestos in the post-war years. The global usage of asbestos remains high, particularly in low- and middle-income countries, which means mesothelioma will become a global problem.

“Mesothelioma is one of the ‘hard-to-treat’ cancers, and the best we can offer people with existing treatments is a few months of extra survival,” said Dr Arsalan Azad from the Cambridge Institute for Medical Research at the University of Cambridge. “There’s an important unmet need for new, effective treatments.”

In 2018, the University of Cambridge was awarded £10million from the Engineering and Physical Sciences Research Council to help develop engineering solutions, including nanotech, to find ways to address hard-to-treat cancers.

In a collaboration between the University of Cambridge and University of Leeds, researchers have developed a form of gold nanotubes whose physical properties are ‘tunable’ – in other words, the team can tailor the wall thickness, microstructure, composition, and ability to absorb particular wavelengths of light.

The researchers added the nanotubes to mesothelioma cells cultured in the lab and found that they were absorbed by the cells, residing close to the nucleus, where the cell’s DNA lies. When the team targeted the cells with a laser, the nanotubes absorbed the light and heated up, killing the mesothelioma cell.

Professor Stefan Marciniak, also from the Cambridge Institute for Medical Research, added: “The mesothelioma cells ‘eat’ the nanotubes, leaving them susceptible when we shine light on them. Laser light is able to penetrate deep into tissue without causing damage to surrounding tissue. It then gets absorbed by the nanotubes, which heat up and, we hope in the future, could be used to cause localised cancer-cell killing.”

The team will be developing the work further to ensure the nanotubes are targeted to cancer cells with less effect on normal tissue.

The nanotubes are made in a two-step process. First, solid silver nanorods are created of the desired diameter. Gold is then deposited from solution onto the surface of the silver. As the gold builds-up at the surface, the silver dissolves from the inside to leave a hollow nanotube.

The approach advanced by the Leeds team allows these nanotubes to be developed at room temperature, which should make their manufacture at scale more feasible.

Professor Stephen Evans from the School of Physics and Astronomy at the University of Leeds said: “Having control over the size and shape of the nanotubes allows us to tune them to absorb light where the tissue is transparent and will allow them to be used for both the imaging and treatment of cancers. The next stage will be to load these nanotubes with medicines for enhanced therapies.”

Here`s a link to and a citation for the paper,

Exploring High Aspect Ratio Gold Nanotubes as Cytosolic Agents: Structural Engineering and Uptake into Mesothelioma Cells by Sunjie Ye, Arsalan A. Azad, Joseph E. Chambers, Alison J. Beckett, Lucien Roach, Samuel C. T. Moorcroft, Zabeada Aslam, Ian A. Prior, Alexander F. Markham, P. Louise Coletta, Stefan J. Marciniak, Stephen D. Evans. Small DOI: https://doi.org/10.1002/smll.202003793 First published: 25 October 2020

This paper is open access.

Gold sheets that are two atoms thick

The gold sheets in question are effectively 2D. I’m surprised they haven’t named them ‘goldene’ as everything else that’s 2D seems to have an ‘ene’ suffix (e.g. graphene, germanene, tellurene).

Of course, these gold sheets are not composed of single atoms but of two according to an August 6, 2019 news item on Nanowerk,

Scientists at the University of Leeds [UK] have created a new form of gold which is just two atoms thick – the thinnest unsupported gold ever created.

The researchers measured the thickness of the gold to be 0.47 nanometres – that is one million times thinner than a human finger nail. The material is regarded as 2D because it comprises just two layers of atoms sitting on top of one another. All atoms are surface atoms – there are no ‘bulk’ atoms hidden beneath the surface.

Caption: Image shows gold nanosheets that are just two atoms thick Credit: University of Leeds

I’m pretty sure they’ve added colour to those images and not just in the background; they’ve likely added a gold colour to the gold.

An August 6, 2019 University of Leeds press release (also on EurekAlert), which originated the news item, gives some insight into the scientists’ ambitions and some technical details about the work,

The material could have wide-scale applications in the medical device and electronics industries – and also as a catalyst to speed up chemical reactions in a range of industrial processes.

Laboratory tests show that the ultra-thin gold is 10 times more efficient as a catalytic substrate than the currently used gold nanoparticles, which are 3D materials with the majority of atoms residing in the bulk rather than at the surface.

Scientists believe the new material could also form the basis of artificial enzymes that could be applied in rapid, point-of-care medical diagnostic tests and in water purification systems.

The announcement that the ultra-thin metal had been successfully synthesised was made in the journal Advanced Science.

The lead author of the paper, Dr Sunjie Ye, from Leeds’ Molecular and Nanoscale Physics Group and the Leeds Institute of Medical Research, said: “This work amounts to a landmark achievement.

“Not only does it open up the possibility that gold can be used more efficiently in existing technologies, it is providing a route which would allow material scientists to develop other 2D metals.

“This method could innovate nanomaterial manufacturing.”

The research team are looking to work with industry on ways of scaling-up the process.

Synthesising the gold nanosheet takes place in an aqueous solution and starts with chloroauric acid, an inorganic substance that contains gold. It is reduced to its metallic form in the presence of a ‘confinement agent’ – a chemical that encourages the gold to form as a sheet, just two atoms thick.

Because of the gold’s nanoscale dimensions, it appears green in water – and given its shape, the researchers describe it as gold nanoseaweed.

Images taken from an electron microscope reveal the way the gold atoms have formed into a highly organised lattice. Other images show gold nanoseaweed that has been artificially coloured. The images are available for download: https://drive.google.com/drive/folders/
1-jxr7KW_RW4vF4-zReh9rnfOQMesb6MI?usp=sharing

Professor Stephen Evans, head of the Leeds’ Molecular and Nanoscale Research Group who supervised the research, said the considerable gains that could be achieved from using these ultra-thin gold sheets are down to their high surface-area to volume ratio.

He said: “Gold is a highly effective catalyst. Because the nanosheets are so thin, just about every gold atom plays a part in the catalysis. It means the process is highly efficient.”

Standard benchmark tests revealed that gold nanoscale sheets were ten times more efficient than the gold nanoparticles conventionally used in industry.

Professor Evans said: “Our data suggests that industry could get the same effect from using a smaller amount of gold, and this has economic advantages when you are talking about a precious metal.”

Similar benchmark tests revealed that the gold sheets could act as highly effective artificial enzymes.

The flakes are also flexible, meaning they could form the basis of electronic components for bendable screens, electronic inks and transparent conducting displays.

Professor Evans thinks there will inevitably be comparisons made between the 2D gold and the very first 2D material ever created – graphene, which was fabricated at the University of Manchester in 2004.

He said: “The translation of any new material into working products can take a long time and you can’t force it to do everything you might like to. With graphene, people have thought that it could be good for electronics or for transparent coatings – or as carbon nanotubes that could make an elevator to take us into space because of its super strength.

“I think with 2D gold we have got some very definite ideas about where it could be used, particularly in catalytic reactions and enzymatic reactions. We know it will be more effective than existing technologies – so we have something that we believe people will be interested in developing with us.”

Here’s a link to and a citation for the paper,

Sub‐Nanometer Thick Gold Nanosheets as Highly Efficient Catalysts by Sunjie Ye, Andy P. Brown, Ashley C. Stammers, Neil H. Thomson, Jin Wen, Lucien Roach, Richard J. Bushby, Patricia Louise Coletta, Kevin Critchley, Simon D. Connell, Alexander F. Markham, Rik Brydson, Stephen D. Evans. Advnaced Science https://doi.org/10.1002/advs.201900911 First published: 06 August 2019

This paper is open access.

Better anti-parasitic medicine delivery with chitosan-based nanocapsules

I mage: The common liver fluke which can cause fascioliasis. Credit: Wikimedia creative commons Courtesy: Leeds University

It looks like a pair of lips to me but, according to a December 12, 2018 news item on Nanowerk, this liver fluke heralds a flatworm infection is a serious health problem,

An international team, led by Professor Francisco Goycoolea from the University of Leeds [UK] and Dr Claudio Salomon from the Universidad Nacional de Rosario, Argentina, and in collaboration with colleagues at the University of Münster, Germany, have developed a novel pharmaceutical formulation to administer triclabendazole – an anti-parasitic drug used to treat a type of flatworm infection – in billions of tiny capsules.

The World Health Organisation estimates that 2.4 million people are infected with fascioliasis, the disease caused by flatworms and treated with triclabendazole.

A December 12, 2018 University of Leeds  press release (also on EurekAlert), which originated the news item,

Anti-parasitic drugs do not become effective until they dissolve and are absorbed. Traditionally, these medicines are highly insoluble and this limits their therapeutic effect.
In a bid to overcome this limitation and accomplish the new formulation, the team used “soft” nanotechnology and nanomedicine approaches, which utilises the self-assembly properties of organic nanostructures and uses techniques in which components, such as polymers and surfactants in solution, play key roles.

Their formulation produces capsules that are less than one micron in size – the diameter of a human hair is roughly 75 microns. These tiny capsules are loaded with triclabendazole and then bundled together to deliver the required dose.

The team used chitosan, a naturally-occurring sugar polymer found in the exoskeleton of shellfish and the cell walls of certain fungi, to coat the oil-core of capsules and bind the drug together, while stabilising the capsule and helping to preserve it.
In its nanocapsule form, the drug would be 100 times more soluble than its current tablet form.

Professor Goycoolea, from the School of Food Science and Nutrition at Leeds, said: “Solubility is critical challenge for effective anti-parasite medicine. We looked to tackle this problem at the particle level. Triclabendazole taken as a dose made up of billions of tiny capsules would mean the medicine would be more efficiently and quickly absorbed

“Through the use of nanocapsules and nanoemulsions, drug efficiency can be enhanced and new solutions can be considered for the best ways to target medicine delivery.”
Dr Salomon said: “To date, this is the first report on triclabendazole nanoencapsulation and we believe this type of formulation could be applied to other anti-parasitic drugs as well. But more research is needed to ensure this new pharmaceutical formulation of the drug does not diminish the anti-parasitic effect. Our ongoing research is working to answer this very question.”

Although there have been cases of fascioliasis in more than 70 countries worldwide, with increasing reports from Europe and the Americas, it is considered a neglected disease, as it does not receive much attention and often goes untreated.
Symptoms of the disease when it reaches the chronic phase include intermittent pain, jaundice and anaemia. Patients can also experience hardening of the liver in the case of long-term inflammation.

Because of the highly insoluble nature of anti-parasitic drugs, they need to be administered in very high dosages to ensure enough of the active ingredient is absorbed. This is particularly problematic when treating children for parasites. Tablets needs to be divided into smaller pieces to adjust the dosage and make swallowing easier, but this can cause side effects due to incorrect dosage.

The team’s technique to formulate triclabendazole into nanocapsules, published today [Dec. 12, 2018] in the journal PLOS ONE, would also allow for lower doses to be administered. s

Here’s a link to and a citation for the paper,

Chitosan-based nanodelivery systems applied to the development of novel triclabendazole formulations by Daniel Real, Stefan Hoffmann, Darío Leonardi, Claudio Salomon, Francisco M. Goycoolea. PLOS DOI https://doi.org/10.1371/journal.pone.0207625 Published: December 12, 2018

This paper is open access. BTW, I loved the title for the press release (Helping the anti-parasitic medicine go down) for its reference to the song, A spoonful of sugar helps the medicine go down, in the 1964 film musical, Mary Poppins, and the shout out for the sort of sequel, Mary Poppins Returns, released on Dec. 19, 2018.

Mimicking nature’s ‘anti-freeze’

Some frogs can survive being frozen for weeks and that’s the property scientists at the University of Leeds (UK) are trying to mimic according to a May 19, 2016 news item on Nanowerk (Note: A link has been removed),

The new research, published today [May 18, 2016] in the print edition of the Journal of Physical Chemistry B (“Low-Density Water Structure Observed in a Nanosegregated Cryoprotectant Solution at Low Temperatures from 285 to 238 K”), reveals how glycerol prevents ice crystals from forming in water as the solution is cooled to -35°C, with important implications for improving cryoprotectants used in fertility treatments and food storage.

A May 19, 2016 University of Leeds press release (also on EurekAlert), which originated the news item, provides more detail (Note: A link has been removed),

Dr Lorna Dougan from the University’s School of Physics and Astronomy, who leads the research group, said: “The experiments provide more insight into the fundamental properties of water. It raises questions about what cryoprotectants are doing in living organisms and could help us take steps to understanding how these organisms survive.

“If we understand what glycerol is doing we might be able to fine-tune some of these cryoprotectants that are used to find more effective combinations.”

Cryoprotectant molecules, including glycerol, play an important role in protecting cells and tissues from harmful ice crystals when they are cooled to sub-zero temperatures during freeze storage. Experts have adopted the use of cryoprotectants in fertility treatments and food storage, but not as effectively as in nature.

It is the ability of organisms that can survive in extreme cold environments – known as ‘psychrophiles’ – that inspired the team of physicists to unpick the biological rules that allow their survival.

In winter months, for example, the Eastern Wood frog in North America survives being frozen to temperatures as low as -8°C for weeks, and then in spring thaws out and continues to live perfectly healthily.

To understand how reptiles like the Eastern Wood frog can freeze and thaw, the team used a Science and Technology Facilities Council (STFC) instrument called SANDALS that was purpose-built for investigating the structure of liquids and amorphous materials.

They wanted to answer the fundamental question of how cryoprotectants alter the structure of water at low temperatures, as it is the water structure that is so important in leading to potential ice damage.

The SANDALS instrument allowed the team to see, at the molecular level, that the water and glycerol segregated into clusters. When they looked in more detail, they found the water looked similar to a low density form of itself, showing all the signs it was about to freeze but then it did not. Instead, the glycerol molecules encapsulated the water, preventing the formation of an icy network.

The team will now use these results as a platform for discovering the next generation of cryoprotectants.

Here’s a link to and a citation for the paper,

Low-Density Water Structure Observed in a Nanosegregated Cryoprotectant Solution at Low Temperatures from 285 to 238 K by J. J. Towey, A. K. Soper, and L. Dougan. J. Phys. Chem. B, 2016, 120 (19), pp 4439–4448 DOI: 10.1021/acs.jpcb.6b01185 Publication Date (Web): March 18, 2016

Copyright © 2016 American Chemical Society

This paper is behind a paywall.

I did search for images of Eastern Wood Frogs but they have to be paid for. These frogs must be a very much in demand as I’ve haven’t encountered this before. You can usually find what you want on Wikipedia or on a frog enthusiast site. It’s not an Eastern one but here’s a Wood Frog (from Wikipedia),

Lithobates sylvaticus (Woodfrog) Date: 3 July 2011, 19:31 Author:Brian Gratwicke This file is licensed under the Creative Commons Attribution 2.0 Generic license.

Lithobates sylvaticus (Woodfrog)
Date: 3 July 2011, 19:31
Author: Brian Gratwicke
This file is licensed under the Creative Commons Attribution 2.0 Generic license.

The sound of moving data

In fact, scientists from the University of Sheffield (UK) and the University of Leeds (UK) have found a way to move data easily and quickly by using sound waves. From a Nov. 3, 2015 news item on ScienceDaily,

Nothing is more frustrating that watching that circle spinning in the centre of your screen, while you wait for your computer to load a programme or access the data you need. Now a team from the Universities of Sheffield and Leeds may have found the answer to faster computing: sound.

The research — published in Applied Physics Letters — has shown that certain types of sound waves can move data quickly, using minimal power.

A Nov. 3, 2015 University of Sheffield news release on EurekAlert, which originated the news item, explains some of the issues with data and memory before briefly describing how sound waves could provide a solution,

The world’s 2.7 zettabytes (2.7 followed by 21 zeros) of data are mostly held on hard disk drives: magnetic disks that work like miniaturised record players, with the data read by sensors that scan over the disk’s surface as it spins. But because this involves moving parts, there are limits on how fast it can operate.

For computers to run faster, we need to create “solid-state” drives that eliminate the need for moving parts – essentially making the data move, not the device on which it’s stored. Flash-based solid-state disk drives have achieved this, and store information electrically rather than magnetically. However, while they operate much faster than normal hard disks, they last much less time before becoming unreliable, are much more expensive and still run much slower than other parts of a modern computer – limiting total speed.

Creating a magnetic solid-state drive could overcome all of these problems. One solution being developed is ‘racetrack memory’, which uses tiny magnetic wires, each one hundreds of times thinner than a human hair, down which magnetic “bits” of data run like racing cars around a track. Existing research into racetrack memory has focused on using magnetic fields or electric currents to move the data bits down the wires. However, both these options create heat and reduce power efficiency, which will limit battery life, increase energy bills and CO2 emissions.

Dr Tom Hayward from the University of Sheffield and Professor John Cunningham from the University of Leeds have together come up with a completely new solution: passing sound waves across the surface on which the wires are fixed. They also found that the direction of data flow depends on the pitch of the sound generated – in effect they “sang” to the data to move it.

The sound used is in the form of surface acoustic waves – the same as the most destructive wave that can emanate from an earthquake. Although already harnessed for use in electronics and other areas of engineering, this is the first time surface acoustic waves have been applied to a data storage system.

Dr Hayward, from Sheffield’s Faculty of Engineering, said: “The key advantage of surface acoustic waves in this application is their ability to travel up to several centimetres without decaying, which at the nano-scale is a huge distance. Because of this, we think a single sound wave could be used to “sing” to large numbers of nanowires simultaneously, enabling us to move a lot of data using very little power. We’re now aiming to create prototype devices in which this concept can be fully tested.”

Here’s a link to and a citation for the paper,

A sound idea: Manipulating domain walls in magnetic nanowires using surface acoustic waves by J. Dean, M. T. Bryan, J. D. Cooper, A. Virbule, J. E. Cunningham, and T. J. Hayward. Appl. Phys. Lett. 107, 142405 (2015); http://dx.doi.org/10.1063/1.4932057

This is an open access paper.

Dexter Johnson in a Nov. 5, 2015 posting on his Nanoclast blog (on the IEEE [Institute of Electrical and Electronics Engineers] website) provides a few additional details about the work such as a brief mention of IBM’s work developing racetrack memory, also known as, a non-volatile memory device.

Watching motor proteins at work

Researchers in the UK and in Japan have described these motor proteins as ‘swinging on monkey bars’,

A Sept. 14, 2015 news item on Nanowerk provides more information about the motor protein observations,

These proteins are vital to complex life, forming the transport infrastructure that allows different parts of cells to specialise in particular functions. Until now, the way they move has never been directly observed.

Researchers at the University of Leeds and in Japan used electron microscopes to capture images of the largest type of motor protein, called dynein, during the act of stepping along its molecular track.

A Sept 14, 2015 Leeds University press release, (also on EurekAlert*) which originated the news item, expands on the theme with what amounts to a transcript of sorts for the video (Note: Links have been removed),

Dr Stan Burgess, at the University of Leeds’ School of Molecular and Cellular Biology, who led the research team, said: “Dynein has two identical motors tied together and it moves along a molecular track called a microtubule. It drives itself along the track by alternately grabbing hold of a binding site, executing a power stroke, then letting go, like a person swinging on monkey bars.

“Previously, dynein movement had only been tracked by attaching fluorescent molecules to the proteins and observing the fluorescence using very powerful light microscopes. It was a bit like tracking vehicles from space with GPS. It told us where they were, their speed and for how long they ran, stopped and so on, but we couldn’t see the molecules in action themselves. These are the first images of these vital processes.”

An understanding of motor proteins is important to medical research because of their fundamental role in complex cellular life. Many viruses hijack motor proteins to hitch a ride to the nucleus for replication. Cell division is driven by motor proteins and so insights into their mechanics could be relevant to cancer research. Some motor neurone diseases are also associated with disruption of motor protein traffic.

The team at Leeds, working within the world-leading Astbury Centre for Structural Molecular Biology, combined purified microtubules with purified dynein motors and added the chemical fuel ATP (adenosine triphosphate) to power the motor.

Dr Hiroshi Imai, now Assistant Professor in the Department of Biological Sciences at Chuo University, Japan, carried out the experiments while working at the University of Leeds.

He explained: “We set the dyneins running along their tracks and then we froze them in ‘mid-stride’ by cooling them at about a million degrees a second, fast enough to prevent the water from forming ice crystals as it solidified. Then using a cryo-electron microscope we took many thousands of images of the motors caught during the act of stepping. By combining many images of individual motors, we were able to sharpen up our picture of the dynein and build up a dynamic idea of how it moved. It is a bit like figuring out how to swing along monkey bars by studying photographs of many people swinging on them.”

Dr Burgess said: “Our most striking discovery was the existence of a hinge between the long, thin stalk and the ‘grappling hook’, like the wrist between a human arm and hand. This allows a lot of variation in the angle of attachment of the motor to its track.

“Each of the two arms of a dynein motor protein is about 25 nanometres (0.000025 millimetre) long, while the binding sites it attaches to are only 8 nanometres apart. That means dynein can reach not only the next rung but the one after that and the one after that and appears to give it flexibility in how it moves along the ‘track’.”

Dynein is not only the biggest but also the most versatile of the motor proteins in living cells and, like all motor proteins, is vital to life. Motor proteins transport cargoes and hold many cellular components in position within the cell. For instance, dynein is responsible for carrying messages from the tips of active nerve cells back to the nucleus and these messages keep the nerve cells alive.

Co-author Peter Knight, Professor of Molecular Contractility in the University of Leeds’ School of Molecular and Cellular Biology, said: “If a cell is like a city, these are like the truckers on its road and rail networks. If you didn’t have a transport system, you couldn’t have specialised regions. Every part of the cell would be doing the same thing and that would mean you could not have complex life.”

“Dynein is the multi-purpose vehicle of cellular transport. Other motor proteins, called kinesins and myosins, are much smaller and have specific functions, but dynein can turn its hand to a lot of different of functions,” Professor Knight said.

For instance, in the motor neurone connecting the central nervous system to the big toe—which is a single cell a metre long— dynein provides the transport from the toe back to the nucleus. Another vital role is in the movement of cells.

Dr Burgess said: “During brain development, neurones must crawl into their correct position and dynein molecules in this instance grab hold of the nucleus and pull it along with the moving mass of the cell. If they didn’t, the nucleus would be left behind and the cytoplasm would crawl away.”

The study involved researchers from the University of Leeds and Japan’s Waseda and Osaka universities, as well as the Quantitative Biology Center at Japan’s Riken research institute and the Japan Science and Technology Agency (JST). The research was funded by the Human Frontiers Science Program and the Biotechnology and Biological Sciences Research Council (BBSRC).

Here’s a link to and a citation for the paper,

Direct observation shows superposition and large scale flexibility within cytoplasmic dynein motors moving along microtubules by Hiroshi Imai, Tomohiro Shima, Kazuo Sutoh, Matthew L. Walker, Peter J. Knight, Takahide Kon, & Stan A. Burgess. Nature Communications 6, Article number: 8179  doi:10.1038/ncomms9179 Published 14 September 2015

This paper is open access.

*The EurekAlert link added Sept. 15, 2015 at 1200 hours PST.

Gold nanotubes could be used in cancer therapies

Where nanotubes are concerned I don’t often see mention of any type other than ‘carbon’ nanotubes so, this Feb. 12, 2015 nanomedicine news item on ScienceDaily featuring ‘gold’ nanotubes caught my attention,

Scientists have shown that gold nanotubes have many applications in fighting cancer: internal nanoprobes for high-resolution imaging; drug delivery vehicles; and agents for destroying cancer cells.

The study, published today in the journal Advanced Functional Materials, details the first successful demonstration of the biomedical use of gold nanotubes in a mouse model of human cancer.

A Feb. 13, 2015 University of Leeds press release, which originated the news item despite what the publication date suggests, describes the research in more detail (Note: Links have been removed),

Study lead author Dr Sunjie Ye, who is based in both the School of Physics and Astronomy and the Leeds Institute for Biomedical and Clinical Sciences at the University of Leeds, said:  “High recurrence rates of tumours after surgical removal remain a formidable challenge in cancer therapy. Chemo- or radiotherapy is often given following surgery to prevent this, but these treatments cause serious side effects.

Gold nanotubes – that is, gold nanoparticles with tubular structures that resemble tiny drinking straws – have the potential to enhance the efficacy of these conventional treatments by integrating diagnosis and therapy in one single system.”

The researchers say that a new technique to control the length of nanotubes underpins the research. By controlling the length, the researchers were able to produce gold nanotubes with the right dimensions to absorb a type of light called ‘near infrared’.

The study’s corresponding author Professor Steve Evans, from the School of Physics and Astronomy at the University of Leeds, said: “Human tissue is transparent for certain frequencies of light – in the red/infrared region. This is why parts of your hand appear red when a torch is shone through it.

“When the gold nanotubes travel through the body, if light of the right frequency is shone on them they absorb the light. This light energy is converted to heat, rather like the warmth generated by the Sun on skin. Using a pulsed laser beam, we were able to rapidly raise the temperature in the vicinity of the nanotubes so that it was high enough to destroy cancer cells.”

In cell-based studies, by adjusting the brightness of the laser pulse, the researchers say they were able to control whether the gold nanotubes were in cancer-destruction mode, or ready to image tumours.

In order to see the gold nanotubes in the body, the researchers used a new type of  imaging technique called ‘multispectral optoacoustic tomography’ (MSOT) to detect the gold nanotubes in mice, in which gold nanotubes had been injected intravenously. It is the first biomedical application of gold nanotubes within a living organism. It was also shown that gold nanotubes were excreted from the body and therefore are unlikely to cause problems in terms of toxicity, an important consideration when developing nanoparticles for clinical use.

Study co-author Dr James McLaughlan, from the School of Electronic & Electrical Engineering at the University of Leeds, said: “This is the first demonstration of the production, and use for imaging and cancer therapy, of gold nanotubes that strongly absorb light within the ‘optical window’ of biological tissue.

“The nanotubes can be tumour-targeted and have a central ‘hollow’ core that can be loaded with a therapeutic payload. This combination of targeting and localised release of a therapeutic agent could, in this age of personalised medicine, be used to identify and treat cancer with minimal toxicity to patients.”

The use of gold nanotubes in imaging and other biomedical applications is currently progressing through trial stages towards early clinical studies.

Here’s a link to and a citation for the paper,

Engineering Gold Nanotubes with Controlled Length and Near-Infrared Absorption for Theranostic Applications by Sunjie Ye, Gemma Marston, James R. McLaughlan, Daniel O. Sigle, Nicola Ingram, Steven Freear, Jeremy J. Baumberg, Richard J. Bushby, Alexander F. Markham, Kevin Critchley, Patricia Louise Coletta, and Stephen D. Evans. Advanced Functional Materials DOI: 10.1002/adfm.201404358 Article first published online: 12 FEB 2015

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

This paper is behind a paywall.