Tag Archives: University of Minho

Chemistry of opera

Kate Yandell has written a thoroughly fascinating article about opera and chemistry (Atoms and Arias) for the Mar. 23, 2013 issue of The Scientist,

In a paper published earlier this year (January 14) in the Journal of Chemical Education, André [João Paulo André], who is now a professor at the University of Minho in Portugal, described his strategy for exploring the links between chemistry and opera for educational purposes.

According to André, the pairing is a natural one, as opera actually chronicled the heady, early days of chemical discovery. Joseph Haydn’s Der Apotheker (also known as Lo Speziale) and Gaetano Donizetti’s one-act opera, Il Campanello, for example, both featured pharmacists as main characters. In 1768, as Joseph Priestley, Antoine Lavoisier, and Carl Wilhelm Scheele, who would eventually discover oxygen, were immersed in their chemical labors, Haydn debuted Der Apotheker, a story about competition and love that plays out in the pharmacy. “There was something in the air. Chemistry was coming to be called a modern science,” Andé says. Il Campanello was first performed publicly in 1836, a time when many natural compounds were being isolated. It includes songs about long, complicated prescriptions. These “apothecary operas” illustrate the cultural pull chemistry used to have.

The researcher’s paper, published in the Journal of Chemical Education, has received worldwide interest. Meanwhile, Yandell’s article inspired this Mar. 24, 2013 posting on Les Vérités Scientifiques,

La constatation que nous livre l’auteur constitue-t-elle une surprise ? Non, car il en est de l’Opéra comme il en est de toute d’autre production artistique, littérature, peinture, musique : la mise en évidence d’une interpénétration entre l’actualité de  la science et l’art. Chaque époque de la société se reflète dans ce que choisissent d’exprimer ses différents acteurs ce qui permet de regarder efficacement derrière soi (cf l’exposition L’ange du bizarre. Le romantisme noir de Goya à Max Ernst au musée d’Orsay).

This is going to be a rough (very) translation and any errors are entirely mine,

The relationship between opera and chemistry should not be a surprise since opera like all the other artistic enterprises such as literature, painting, music always reflect the social and scientific interests of their own epochs as we can see in various venues, e.g. L’ange du bizarre: the dark romanticism of artists ranging from Goya to Max Ernst at the musée d’Orsay [in Paris].

As Yandell’s article notes others have observed a relationship between opera and chemistry (Links have been removed),

Jorge Calado, a retired Portuguese chemistry professor and an opera critic for the Portuguese newspaper Expresso, saw André’s talk and helped edit the Journal of Chemical Education paper. …

Calado published a book in Portuguese in 2011 whose title translates to Let There be Light! A History of Chemistry Through Everything, in which he tells the story of chemistry’s early roots through the lens of the arts and humanities, including opera.

He says that André’s paper made him want to write his own follow-up paper, and that he could think of even more examples of operas with connections to chemistry—from Jacques Offenbach’s Le Docteur Ox (1877), based on a story by science fiction writer Jules Verne, to John Adams’ Doctor Atomic (2005), which chronicles the creation of the atom bomb in Los Alamos.

Aside from the fact that it’s well worth reading, Yandell’s article is studded with opera videos that enhance the opera/chemistry relationships being described.

Here’s a link to and a citation for the research article,

Opera and Poison: A Secret and Enjoyable Approach To Teaching and Learning Chemistry by João Paulo André. J. Chem. Educ., 2013, 90 (3), pp 352–357 DOI: 10.1021/ed300445b
Publication Date (Web): January 14, 2013
Copyright © 2013 The American Chemical Society and Division of Chemical Education, Inc.

This article is behind a paywall.

The Feb. 14, 2013 posting on the Smithsonian blog offers a little more information about the project,

Any good opera needs a dramatic twist, and death by poison and potions fits the bill. When a team of chemists took a closer look at the formulas behind these concoctions in 20 operas, they found 25 different natural and synthetic chemical materials featured. The researchers suggest that teachers use these poison plots to engage students with chemistry, and while opera isn’t exactly an easy sell with most teenagers, learning about death by deadly nightshade probably ranks higher for most than memorizing yet another chemical formula.

The Smithsonian posting also offers a few tidbits from beyond the article’s paywall.

I believe this is a case where a few people independently had similar ideas as there is a professor in Germany who has also combined chemistry and opera although he has turned to performance. Professor Dr. Gerald Linti, at Heidelberg University has been staging musical chemistry experiments since 2004 if I’ve properly understood the German on his Special Events webpage,

  • Lange Nacht im Schloss (März 2004)

  “Chemie und Oper für Jedermann: Tannhäuser”

More recently (2009), Linti produced a Puccini night as part of his ongoing Chemistry and Opera series,

Under the title “Turandot’s Three Chemical Riddles” Gerald Linti, professor at Heidelberg University’s Institute of Inorganic Chemistry, and his students will be giving another demonstration of their legendary skill in the musical staging of chemical experiments at 6 p.m. on 26 June 2009.

He seems to have followed that up with a 2011 opera night at a conference titled, Modeling Molecular Properties, according to an Oct. 11, 2011 article by Sarah Miller for Chemistry Views,

The first day concluded with the spectacular “Chemistry and Opera” arranged by Professor Gerald Linti, University of Heidelberg. This demonstrated the beauty and fun of chemistry as Linti told the story of a Chinese Princess while his assistants performed chemistry experiments in time to live opera.

This sounds like a restaging of ‘Turandot’s Three Chemical Riddles’ from 2009. Here’s one of the images which illustrates Miller’s article,

[Downloaded from: http://www.chemistryviews.org/details/ezine/1371029/Modeling_Molecular_Properties_and_Opera.html]

[Downloaded from: http://www.chemistryviews.org/details/ezine/1371029/Modeling_Molecular_Properties_and_Opera.html]

Maybe it’s time for a new ‘chemistry’ opera. Any takers?

Could nanoparticles in your mouthwash affect for your cells?

The first news item I’m going to highlight was posted on Nanowerk, March 8, 2012 and is focused on the use of silver nanoparticles in mouthwashes and dentures to prevent yeast infections,

Yeasts which cause hard-to-treat mouth infections are killed using silver nanoparticles in the laboratory, scientists have found. These yeast infections, caused by Candida albicans and Candida glabrata target the young, old and immuno-compromised. Professor Mariana Henriques, University of Minho [Portugal], and her colleagues hope to test silver nanoparticles in mouthwash and dentures as a potential preventative measure against these infections.

Professor Henriques and her team, who published their research in the Society for Applied Microbiology’s journal Letters in Applied Microbiology(“Silver nanoparticles: influence of stabilizing agent and diameter on antifungal activity against Candida albicans and Candida glabrata biofilms”), looked at the use of different sizes of silver nanoparticles to determine their anti-fungal properties …

The scientists used artificial biofilms in conditions which mimic those of saliva as closely as possible. They then added different sizes and concentrations of silver nanoparticles and found that different sizes of nanoparticles were equally effective at killing the yeasts. Due to the diversity of the sizes of nanoparticles demonstrating anti-fungal properties the researchers hope this will enable the nanoparticles to be used in many different applications.

Some researchers have expressed concerns around the safety of nanoparticle use but the authors stress this research is at an early stage and extensive safety trials will be carried out before any product reaches the market. [emphasis mine]

Following on the notion of safety and gargling silver nanoparticles, coincidentally, there was another news item also dated March 8, 2012 on Nanowerk, this one about the impact that nanoparticles may have on nutrient uptake,

Nanoparticles are everywhere. From cosmetics and clothes, to soda and snacks. But as versatile as they are, nanoparticles also have a downside, say researchers at Binghamton University and Cornell University in a recent paper published in the journal Nature Nanotechnology (“Oral exposure to polystyrene nanoparticles affects iron absorption”). These tiny particles, even in low doses, could have a big impact on our long-term health.

According to lead author of the article, Gretchen Mahler, assistant professor of bioengineering at Binghamton University, much of the existing research on the safety of nanoparticles has been on the direct health effects. But what Mahler, Michael L. Shuler of Cornell University and a team of researchers really wanted to know was what happens when someone gets constant exposure in small doses – the kind you’d get if you were taken a drug or supplement that included nanoparticles in some form. [e.g. silver nanoparticles in your mouthwash or on your dentures]

“We thought that the best way to measure the more subtle effects of this kind of intake was to monitor the reaction of intestinal cells,” said Mahler. “And we did this in two ways: in vitro, through human intestinal-lining cells that we had cultured in the lab; and in vivo, through the intestinal linings of live chickens. Both sets of results pointed to the same thing – that exposure to nanoparticles influences the absorption of nutrients into the bloodstream.”

As for why the researchers focused on iron and tested polystyrene nanoparticles (from the news item),

The uptake of iron, an essential nutrient, was of particular interest due to the way it is absorbed and processed through the intestines. The way Mahler and the team tested this was to use polystyrene nanoparticles because of its easily traceable fluorescent properties.

“What we found was that for brief exposures, iron absorption dropped by about 50 percent,” said Mahler. “But when we extended that period of time, absorption actually increased by about 200 percent. It was very clear – nanoparticles definitely affects iron uptake and transport.”

While acute oral exposure caused disruptions to intestinal iron transport, chronic exposure caused a remodeling of the intestinal villi – the tiny, finger-like projections that are vital to the intestine’s ability to absorb nutrients – making them larger and broader, thus allowing iron to enter the bloodstream much faster.

As to whether these changes are good or bad the researchers don’t speculate. They do have plans for more testing,

calcium,
copper,
zinc, and
fat-soluble vitamins A, D, E and K

They don’t mention any changes in the types of nanoparticles they might be testing in future.

In any event, our bodies have changed a lot over the centuries, you just have to visit a pyramid in Egypt or a museum that holds medieval armour to observe that humans were once much shorter than we are today.