From gene mapping to space exploration, humanity continues to generate ever-larger sets of data—far more information than people can actually process, manage, or understand.
Machine learning systems can help researchers deal with this ever-growing flood of information. Some of the most powerful of these analytical tools are based on a strange branch of geometry called topology, which deals with properties that stay the same even when something is bent and stretched every which way.
Such topological systems are especially useful for analyzing the connections in complex networks, such as the internal wiring of the brain, the U.S. power grid, or the global interconnections of the Internet. But even with the most powerful modern supercomputers, such problems remain daunting and impractical to solve. Now, a new approach that would use quantum computers to streamline these problems has been developed by researchers at [Massachusetts Institute of Technology] MIT, the University of Waterloo, and the University of Southern California [USC}.
… Seth Lloyd, the paper’s lead author and the Nam P. Suh Professor of Mechanical Engineering, explains that algebraic topology is key to the new method. This approach, he says, helps to reduce the impact of the inevitable distortions that arise every time someone collects data about the real world.
In a topological description, basic features of the data (How many holes does it have? How are the different parts connected?) are considered the same no matter how much they are stretched, compressed, or distorted. Lloyd [ explains that it is often these fundamental topological attributes “that are important in trying to reconstruct the underlying patterns in the real world that the data are supposed to represent.”
It doesn’t matter what kind of dataset is being analyzed, he says. The topological approach to looking for connections and holes “works whether it’s an actual physical hole, or the data represents a logical argument and there’s a hole in the argument. This will find both kinds of holes.”
Using conventional computers, that approach is too demanding for all but the simplest situations. Topological analysis “represents a crucial way of getting at the significant features of the data, but it’s computationally very expensive,” Lloyd says. “This is where quantum mechanics kicks in.” The new quantum-based approach, he says, could exponentially speed up such calculations.
Lloyd offers an example to illustrate that potential speedup: If you have a dataset with 300 points, a conventional approach to analyzing all the topological features in that system would require “a computer the size of the universe,” he says. That is, it would take 2300 (two to the 300th power) processing units — approximately the number of all the particles in the universe. In other words, the problem is simply not solvable in that way.
“That’s where our algorithm kicks in,” he says. Solving the same problem with the new system, using a quantum computer, would require just 300 quantum bits — and a device this size may be achieved in the next few years, according to Lloyd.
“Our algorithm shows that you don’t need a big quantum computer to kick some serious topological butt,” he says.
There are many important kinds of huge datasets where the quantum-topological approach could be useful, Lloyd says, for example understanding interconnections in the brain. “By applying topological analysis to datasets gleaned by electroencephalography or functional MRI, you can reveal the complex connectivity and topology of the sequences of firing neurons that underlie our thought processes,” he says.
The same approach could be used for analyzing many other kinds of information. “You could apply it to the world’s economy, or to social networks, or almost any system that involves long-range transport of goods or information,” says Lloyd, who holds a joint appointment as a professor of physics. But the limits of classical computation have prevented such approaches from being applied before.
While this work is theoretical, “experimentalists have already contacted us about trying prototypes,” he says. “You could find the topology of simple structures on a very simple quantum computer. People are trying proof-of-concept experiments.”
Ignacio Cirac, a professor at the Max Planck Institute of Quantum Optics in Munich, Germany, who was not involved in this research, calls it “a very original idea, and I think that it has a great potential.” He adds “I guess that it has to be further developed and adapted to particular problems. In any case, I think that this is top-quality research.”
Shown here are the connections between different regions of the brain in a control subject (left) and a subject under the influence of the psychedelic compound psilocybin (right). This demonstrates a dramatic increase in connectivity, which explains some of the drug’s effects (such as “hearing” colors or “seeing” smells). Such an analysis, involving billions of brain cells, would be too complex for conventional techniques, but could be handled easily by the new quantum approach, the researchers say. Courtesy of the researchers
*’also on EurekAlert’ text and link added Jan. 26, 2016.
With oil sands in the title, this story had to mention the Canadian province of Alberta, which has been widely castigated and applauded for its oil extraction efforts in their massive oil sands field. A Nov. 24, 2015 news item on Nanotechnology Now describes a new technology for cleaning the wastewater from oil sands extraction processes,
Researchers have developed a process to remove contaminants from oil sands wastewater using only sunlight and nanoparticles that is more effective and inexpensive than conventional treatment methods.
Frank Gu, a professor in the Faculty of Engineering at the University of Waterloo [in the province of Ontario] and Canada Research Chair in Nanotechnology Engineering, is the senior researcher on the team that was the first to find that photocatalysis — a chemical reaction that involves the absorption of light by nanoparticles — can completely eliminate naphthenic acids in oil sands wastewater, and within hours. Naphthenic acids pose a threat to ecology and human health. Water in tailing ponds left to biodegrade naturally in the environment still contains these contaminants decades later.
“With about a billion tonnes of water stored in ponds in Alberta, removing naphthenic acids is one of the largest environmental challenges in Canada,” said Tim Leshuk, a PhD candidate in chemical engineering at Waterloo. He is the lead author of this paper and a recipient of the prestigious Vanier Canada Graduate Scholarship. “Conventional treatments people have tried either haven’t worked, or if they have worked, they’ve been far too impractical or expensive to solve the size of the problem. Waterloo’s technology is the first step of what looks like a very practical and green treatment method.”
Unlike treating polluted water with chlorine or membrane filtering, the Waterloo technology is energy-efficient and relatively inexpensive. Nanoparticles become extremely reactive when exposed to sunlight and break down the persistent pollutants in their individual atoms, completely removing them from the water. This treatment depends on only sunlight for energy, and the nanoparticles can be recovered and reused indefinitely.
Next steps for the Waterloo research include ensuring that the treated water meets all of the objectives Canadian environmental legislation and regulations required to ensure it can be safely discharged from sources larger than the samples, such as tailing ponds.
I think this is the first time I’ve seen anything about a technology that removes toxic materials from both water and soil; it’s usually one or the other. A July 22, 2015 news item on Nanowerk makes the announcement (Note: A link has been removed),
Many human-made pollutants in the environment resist degradation through natural processes, and disrupt hormonal and other systems in mammals and other animals. Removing these toxic materials — which include pesticides and endocrine disruptors such as bisphenol A (BPA) — with existing methods is often expensive and time-consuming.
In a new paper published this week in Nature Communications (“Nanoparticles with photoinduced precipitation for the extraction of pollutants from water and soil”), researchers from MIT [Massachusetts Institute of Technology] and the Federal University of Goiás in Brazil demonstrate a novel method for using nanoparticles and ultraviolet (UV) light to quickly isolate and extract a variety of contaminants from soil and water.
Ferdinand Brandl and Nicolas Bertrand, the two lead authors, are former postdocs in the laboratory of Robert Langer, the David H. Koch Institute Professor at MIT’s Koch Institute for Integrative Cancer Research. (Eliana Martins Lima, of the Federal University of Goiás, is the other co-author.) Both Brandl and Bertrand are trained as pharmacists, and describe their discovery as a happy accident: They initially sought to develop nanoparticles that could be used to deliver drugs to cancer cells.
Brandl had previously synthesized polymers that could be cleaved apart by exposure to UV light. But he and Bertrand came to question their suitability for drug delivery, since UV light can be damaging to tissue and cells, and doesn’t penetrate through the skin. When they learned that UV light was used to disinfect water in certain treatment plants, they began to ask a different question.
“We thought if they are already using UV light, maybe they could use our particles as well,” Brandl says. “Then we came up with the idea to use our particles to remove toxic chemicals, pollutants, or hormones from water, because we saw that the particles aggregate once you irradiate them with UV light.”
A trap for ‘water-fearing’ pollution
The researchers synthesized polymers from polyethylene glycol, a widely used compound found in laxatives, toothpaste, and eye drops and approved by the Food and Drug Administration as a food additive, and polylactic acid, a biodegradable plastic used in compostable cups and glassware.
Nanoparticles made from these polymers have a hydrophobic core and a hydrophilic shell. Due to molecular-scale forces, in a solution hydrophobic pollutant molecules move toward the hydrophobic nanoparticles, and adsorb onto their surface, where they effectively become “trapped.” This same phenomenon is at work when spaghetti sauce stains the surface of plastic containers, turning them red: In that case, both the plastic and the oil-based sauce are hydrophobic and interact together.
If left alone, these nanomaterials would remain suspended and dispersed evenly in water. But when exposed to UV light, the stabilizing outer shell of the particles is shed, and — now “enriched” by the pollutants — they form larger aggregates that can then be removed through filtration, sedimentation, or other methods.
The researchers used the method to extract phthalates, hormone-disrupting chemicals used to soften plastics, from wastewater; BPA, another endocrine-disrupting synthetic compound widely used in plastic bottles and other resinous consumer goods, from thermal printing paper samples; and polycyclic aromatic hydrocarbons, carcinogenic compounds formed from incomplete combustion of fuels, from contaminated soil.
The process is irreversible and the polymers are biodegradable, minimizing the risks of leaving toxic secondary products to persist in, say, a body of water. “Once they switch to this macro situation where they’re big clumps,” Bertrand says, “you won’t be able to bring them back to the nano state again.”
The fundamental breakthrough, according to the researchers, was confirming that small molecules do indeed adsorb passively onto the surface of nanoparticles.
“To the best of our knowledge, it is the first time that the interactions of small molecules with pre-formed nanoparticles can be directly measured,” they write in Nature Communications.
Even more exciting, they say, is the wide range of potential uses, from environmental remediation to medical analysis.
The polymers are synthesized at room temperature, and don’t need to be specially prepared to target specific compounds; they are broadly applicable to all kinds of hydrophobic chemicals and molecules.
“The interactions we exploit to remove the pollutants are non-specific,” Brandl says. “We can remove hormones, BPA, and pesticides that are all present in the same sample, and we can do this in one step.”
And the nanoparticles’ high surface-area-to-volume ratio means that only a small amount is needed to remove a relatively large quantity of pollutants. The technique could thus offer potential for the cost-effective cleanup of contaminated water and soil on a wider scale.
“From the applied perspective, we showed in a system that the adsorption of small molecules on the surface of the nanoparticles can be used for extraction of any kind,” Bertrand says. “It opens the door for many other applications down the line.”
This approach could possibly be further developed, he speculates, to replace the widespread use of organic solvents for everything from decaffeinating coffee to making paint thinners. Bertrand cites DDT, banned for use as a pesticide in the U.S. since 1972 but still widely used in other parts of the world, as another example of a persistent pollutant that could potentially be remediated using these nanomaterials. “And for analytical applications where you don’t need as much volume to purify or concentrate, this might be interesting,” Bertrand says, offering the example of a cheap testing kit for urine analysis of medical patients.
The study also suggests the broader potential for adapting nanoscale drug-delivery techniques developed for use in environmental remediation.
“That we can apply some of the highly sophisticated, high-precision tools developed for the pharmaceutical industry, and now look at the use of these technologies in broader terms, is phenomenal,” says Frank Gu, an assistant professor of chemical engineering at the University of Waterloo in Canada, and an expert in nanoengineering for health care and medical applications.
“When you think about field deployment, that’s far down the road, but this paper offers a really exciting opportunity to crack a problem that is persistently present,” says Gu, who was not involved in the research. “If you take the normal conventional civil engineering or chemical engineering approach to treating it, it just won’t touch it. That’s where the most exciting part is.”
The researchers have made this illustration of their work available,
Nanoparticles that lose their stability upon irradiation with light have been designed to extract endocrine disruptors, pesticides, and other contaminants from water and soils. The system exploits the large surface-to-volume ratio of nanoparticles, while the photoinduced precipitation ensures nanomaterials are not released in the environment. Image: Nicolas Bertrand Courtesy: MIT
The Seventh Canadian Science Policy Conference, being held in Ottawa, Ontario from Nov. 25 – 27, 2015 at the Delta Ottawa City Centre Hotel, has announced its programme and speakers in a July 16, 2015 Canadian Science Policy Centre newsletter,
Theme 1: Transformative and Converging Technologies on
Private Sector Innovation and Productivity
New technologies, from 3D printing to quantum computing, present risks and opportunities for Canadian industries and the economy. Join CSPC 2015 in a discussion of how Canada’s mining industry and digital economy can best take advantage of these technological innovations.
Theme 2: Big Science in Canada – Realizing the Benefits
ENCode, the LHC, the Very Large Array: Big Science is reshaping modern research and with it, Canada’s scientific landscape. Join the conversation at CSPC 2015 on how Canada navigates those vast new waters.
Theme 5: Evidence-Based Decision Making: The challenge
of connecting science and policy making
GMOs, climate change, energy: Many of the big major issues facing Canada fall at the nexus of science and policymaking. Join CSPC 2015 in a discussion of the role of big data and evidence-based decision-making in government.
Please note, there will be more panels announced soon.
Science Advice to Governments
Innovation, science and technologies never had a more critical role in decision making than today. CSPC 2015 keynote session will address the importance and role of the input from the scientific world to decision making in political affairs.
Sir Peter Gluckman,
Chief Science Adviser to New Zealand Government
Chief Scientist, Quebec
Executive Director, Inst. Nanotechnology U Waterloo, Former science adviser to PM Paul Martin [emphasis mine]
I have a few comments. First, I’m glad to see the balance between the “money, money, money” attitude and more scholarly/policy interests has been evened out somewhat as compared to last year’s conference in Halifax (Nova Scotia). Second, I see there aren’t any politicians listed as speakers in the website’s banner as is the usual case (Ted Hsu, Member of Parliament and current science critic for the Liberal Party, is on the speaker list but will not be running in the 2015 election). This makes some sense since there is a federal election coming up in October 2015 and changes are likely. Especially, since it seems to be a three-horse race at this point. (For anyone unfamiliar with the term, it means that any one of the three main political parties could win and lead should they possess a majority of the votes in the House of Commons. There are other possibilities such as a minority government led by one party (the Harper Conservatives have been in that situation). Or, should two parties, with enough combined votes to outnumber the third party, be able to agree, there could be a coalition government of some kind.) As for other politicians at the provincial and municipal levels, perhaps it’s too early to commit? Third, Arthur Carty, as he notes, was a science advisor to Prime Minister Paul Martin. Martin was the leader of the country for approximately two years from Dec. 2003 – Nov. 2005 when a motion of non confidence was passed in Parliament (more about Paul Martin and his political career in his Wikipedia entry) an election was called for January 2006 when Stephen Harper and the conservatives were voted in to form a minority government. Arthur Carty’s tenure as Canada’s first science advisor began in 2004 and ended in 2008, according to Carty’s Wikipedia entry. It seems Carty is not claiming to have been Stephen Harper’s science advisor although arguably he was the Harper government’s science advisor for the same amount of time. This excerpt from a March 6, 2008 Canada.com news item seems to shed some light on why the Harper sojourn is not mentioned in Cary’s conference biography,
The need for a national science adviser has never been greater and the government is risking damage to Canada’s international reputation as a science leader by cutting the position, according to the man who holds the job until the end of the month.
Appearing before a Commons committee on Thursday, Arthur Carty told MPs that he is “dismayed and disappointed” that the Conservative government decided last fall to discontinue the office of the national science adviser.
“There are, I think, negative consequences of eliminating the position,” said Carty. He said his international counterparts have expressed support for him and that Canada eliminating the position has the “potential to tarnish our image,” as a world leader in science and innovation.
Carty was head of the National Research Council in 2004 when former prime minister Paul Martin asked him to be his science adviser.
In October 2006, [months] after Prime Minister Stephen Harper was elected, Carty’s office was shifted to Industry Canada. After that move, he and his staff were “increasingly marginalized,” Carty told the industry, science and technology committee, and they had little input in crafting the government’s new science and technology strategy.
But Conservative members of the committee questioned whether taxpayers got their money’s worth from the national adviser and asked Carty to explain travel and meal expenses he had claimed during his time in the public service, including lunch and dinner meetings that cost around $1,000 each. Some of the figures they cited were from when Carty was head of the National Research Council.
The suggestions that Carty took advantage of the public purse prompted Liberal MP Scott Brison to accuse the Tories of launching a “smear campaign” against Carty, whom he described as a “great public servant.”
“I have never overcharged the government for anything,” Carty said in his own defence.
The keynote has the potential for some liveliness based on Carty’s history as a science advisor but one never knows. It would have been nice if the organizers had been able to include someone from South Korea, Japan, India, China, etc. to be a keynote speaker on the topic of science advice. After all, those countries have all invested heavily in science and made some significant social and economic progress based on those investments. If you’re going to talk about the global science enterprise perhaps you could attract a few new people (and let’s not forget Latin America, Africa, and the Middle East) to the table, so to speak.
For a long time It seemed as if every country in the world, except Canada, had some some sort of graphene event. According to a July 16, 2015 news item on Nanotechnology Now, Canada has now stepped up, albeit, in a peculiarly Canadian fashion. First the news,
Mid October [Oct. 14 -16, 2015], the Graphene & 2D Materials Canada 2015 International Conference & Exhibition (www.graphenecanada2015.com) will take place in Montreal (Canada).
I found a July 16, 2015 news release (PDF) announcing the Canadian event on the lead organizer’s (Phantoms Foundation located in Spain) website,
On the second day of the event (15th October, 2015), an Industrial Forum will bring together top industry leaders to discuss recent advances in technology developments and business opportunities in graphene commercialization.
At this stage, the event unveils 38 keynote & invited speakers. On the Industrial Forum 19 of them will present the latest in terms of Energy, Applications, Production and Worldwide Initiatives & Priorities.
Gary Economo (Grafoid Inc., Canada)
Khasha Ghaffarzadeh (IDTechEx, UK)
Shu-Jen Han (IBM T.J. Watson Research Center, USA)
Bor Z. Jang (Angstron Materials, USA)
Seongjun Park (Samsung Advanced Institute of Technology (SAIT), Korea)
Chun-Yun Sung (Lockheed Martin, USA)
Gordon Chiu (Grafoid Inc., Canada)
Jesus de la Fuente (Graphenea, Spain)
Mark Gallerneault (ALCERECO Inc., Canada)
Ray Gibbs (Haydale Graphene Industries, UK)
Masataka Hasegawa (AIST, Japan)
Byung Hee Hong (SNU & Graphene Square, Korea)
Tony Ling (Jestico + Whiles, UK)
Carla Miner (SDTC, Canada)
Gregory Pognon (THALES Research & Technology, France)
Elena Polyakova (Graphene Laboratories Inc, USA)
Federico Rosei (INRS–EMT, Université du Québec, Canada)
Aiping Yu (University of Waterloo, Canada)
Hua Zhang (MSE-NTU, Singapore)
Apart from the industrial forum, several industry-related activities will be organized:
– Extensive thematic workshops in parallel (Standardization, Materials & Devices Characterization, Bio & Health and Electronic Devices)
– An exhibition carried out with the latest graphene trends (Grafoid, RAYMOR NanoIntegris, Nanomagnetics Instruments, ICEX and Xerox Research Centre of Canada (XRCC) already confirmed)
– B2B meetings to foster technical cooperation in the field of Graphene
It’s still possible to contribute to the event with an oral presentation. The call for abstracts is open until July, 20 . [emphasis mine]
Graphene Canada 2015 is already supported by Canada’s leading graphene applications developer, Grafoid Inc., Tourisme Montréal and Université de Montréal.
This is what makes the event peculiarly Canadian: multiculturalism, anyone? From the news release,
Organisers: Phantoms Foundation www.phantomsnet.net & Grafoid Foundation (lead organizers)
CEMES/CNRS (France) | Grafoid (Canada) | Catalan Institute of Nanoscience and Nanotechnology – ICN2 (Spain) | IIT (Italy) | McGill University, Canada | Texas Instruments (USA) | Université Catholique de Louvain (Belgium) | Université de Montreal, Canada
It’s billed as a ‘Canada Graphene 2015’ and, as I recall, these types of events don’t usually have so many other countries listed as organizers. For example, UK Graphene 2015 would have mostly or all of its organizers (especially the leads) located in the UK.
Getting to the Canadian content, I wrote about Grafoid at length tracking some of its relationships to companies it owns, a business deal with Hydro Québec, and a partnership with the University of Waterloo, and a nonrepayable grant from the Canadian federal government (Sustainable Development Technology Canada [SDTC]) in a Feb. 23, 2015 posting. Do take a look at the post if you’re curious about the heavily interlinked nature of the Canadian graphene scene and take another look at the list of speakers and their agencies (Mark Gallerneault of ALCERECO [partially owned by Grafoid], Carla Miner of SDTC [Grafoid received monies from the Canadian federal department], Federico Rosei of INRS–EMT, Université du Québec [another Quebec link], Aiping Yu, University of Waterloo [an academic partner to Grafoid]). The Canadian graphene community is a small one so it’s not surprising there are links between the Canadian speakers but it does seem odd that Lomiko Metals is not represented here. Still, new speakers have been announced since the news release (e.g., Frank Koppens of ICFO, Spain, and Vladimir Falko of Lancaster University, UK) so time remains.
Meanwhile, Lomiko Metals has announced in a July 17, 2015 news item on Azonano that Graphene 3D labs has changed the percentage of its outstanding shares affecting the percentage that Lomiko owns, amid some production and distribution announcements. The bit about launching commercial sales of its graphene filament seems more interesting to me,
On March 16, 2015 Graphene 3D Lab (TSXV:GGG) (OTCQB:GPHBF) announced that it launched commercial sales of its Conductive Graphene Filament for 3D printing. The filament incorporates highly conductive proprietary nano-carbon materials to enhance the properties of PLA, a widely used thermoplastic material for 3D printing; therefore, the filament is compatible with most commercially available 3D printers. The conductive filament can be used to print conductive traces (similar to as used in circuit boards) within 3D printed parts for electronics.
So, that’s all I’ve got for Canada’s graphene scene.
I’m pretty sure I’ve said this before but a repetition can’t hurt, “I love glass both for the art and the mystery.” Naturally, I am of two minds about this ‘shattered’ glass mystery from the University of Waterloo (Canada).
A physicist at the University of Waterloo is among a team of scientists who have described how glasses form at the molecular level and provided a possible solution to a problem that has stumped scientists for decades.
Their simple theory is expected to open up the study of glasses to non-experts and undergraduates as well as inspire breakthroughs in novel nanomaterials.
The paper published by physicists from the University of Waterloo, McMaster University, ESPCI ParisTech and Université Paris Diderot appeared in the prestigious peer-reviewed journal, Proceedings of the National Academy of Sciences (PNAS).
Glasses are much more than silicon-based materials in bottles and windows. In fact, any solid without an ordered, crystalline structure — metal, plastic, a polymer — that forms a molten liquid when heated above a certain temperature is a glass. Glasses are an essential material in technology, pharmaceuticals, housing, renewable energy and increasingly nano electronics.
“We were surprised — delighted — that the model turned out to be so simple,” said author James Forrest, a University Research Chair and professor in the Faculty of Science. “We were convinced it had already been published.”
The theory relies on two basic concepts: molecular crowding and string-like co-operative movement. [emphasis mine] Molecular crowding describes how molecules within glasses move like people in a crowded room. As the number of people increase, the amount of free volume decreases and the slower people can move through the crowd. Those people next to the door are able to move more freely, just as the surfaces of glasses never actually stop flowing, even at lower temperatures.
The more crowded the room, the more you rely on the co-operative movement with your neighbours to get where you’re going. Likewise, individual molecules within a glass aren’t able to move totally freely. They move with, yet are confined by, strings of weak molecular bonds with their neighbours.
Theories of crowding and cooperative movement are decades old. This is the first time scientists combined both theories to describe how a liquid turns into a glass.
“Research on glasses is normally reserved for specialists in condensed matter physics,” said Forrest, who is also an associate faculty member at Perimeter Institute for Theoretical Physics and a member of the Waterloo Institute for Nanotechnology. “Now a whole new generation of scientists can study and apply glasses just using first-year calculus.”
Their theory successfully predicts everything from bulk behaviour to surface flow to the once-elusive phenomenon of the glass transition itself. Forrest and colleagues worked for 20 years to bring theory in agreement with decades of observation on glassy materials.
An accurate theory becomes particularly important when trying to understand glass dynamics at the nanoscale. This finding has implications for developing and manufacturing new nanomaterials, such as glasses with conductive properties, or even calculating the uptake of glassy forms of pharmaceuticals.
Here’s a link to and a citation for the paper,
Cooperative strings and glassy interfaces by Thomas Salez, Justin Salez, Kari Dalnoki-Veress, Elie Raphaël, and James A. Forrest. PNAS (Proceedings of the National Academy of Sciences) Published online before print June 22, 2015, doi: 10.1073/pnas.1503133112
A local (Vancouver, Canada-based, quantum computing company, D-Wave is making quite a splash lately due to a technical breakthrough. h/t’s Speaking up for Canadian Science for Business in Vancouver article and Nanotechnology Now for Harris & Harris Group press release and Economist article.
A June 22, 2015 article by Tyler Orton for Business in Vancouver describes D-Wave’s latest technical breakthrough,
“This updated processor will allow significantly more complex computational problems to be solved than ever before,” Jeremy Hilton, D-Wave’s vice-president of processor development, wrote in a June 22  blog entry.
Regular computers use two bits – ones and zeroes – to make calculations, while quantum computers rely on qubits.
Qubits possess a “superposition” that allow it to be one and zero at the same time, meaning it can calculate all possible values in a single operation.
But the algorithm for a full-scale quantum computer requires 8,000 qubits.
Harris & Harris Group, Inc. (Nasdaq: TINY), an investor in transformative companies enabled by disruptive science, notes that its portfolio company, D-Wave Systems, Inc., announced that it has successfully fabricated 1,000 qubit processors that power its quantum computers. D-Wave’s quantum computer runs a quantum annealing algorithm to find the lowest points, corresponding to optimal or near optimal solutions, in a virtual “energy landscape.” Every additional qubit doubles the search space of the processor. At 1,000 qubits, the new processor considers 21000 possibilities simultaneously, a search space which is substantially larger than the 2512 possibilities available to the company’s currently available 512 qubit D-Wave Two. In fact, the new search space contains far more possibilities than there are particles in the observable universe.
A June 22, 2015 D-Wave news release, which originated the technical details about the breakthrough found in the Harris & Harris press release, provides more information along with some marketing hype (hyperbole), Note: Links have been removed,
As the only manufacturer of scalable quantum processors, D-Wave breaks new ground with every succeeding generation it develops. The new processors, comprising over 128,000 Josephson tunnel junctions, are believed to be the most complex superconductor integrated circuits ever successfully yielded. They are fabricated in part at D-Wave’s facilities in Palo Alto, CA and at Cypress Semiconductor’s wafer foundry located in Bloomington, Minnesota.
“Temperature, noise, and precision all play a profound role in how well quantum processors solve problems. Beyond scaling up the technology by doubling the number of qubits, we also achieved key technology advances prioritized around their impact on performance,” said Jeremy Hilton, D-Wave vice president, processor development. “We expect to release benchmarking data that demonstrate new levels of performance later this year.”
The 1000-qubit milestone is the result of intensive research and development by D-Wave and reflects a triumph over a variety of design challenges aimed at enhancing performance and boosting solution quality. Beyond the much larger number of qubits, other significant innovations include:
Lower Operating Temperature: While the previous generation processor ran at a temperature close to absolute zero, the new processor runs 40% colder. The lower operating temperature enhances the importance of quantum effects, which increases the ability to discriminate the best result from a collection of good candidates.
Reduced Noise: Through a combination of improved design, architectural enhancements and materials changes, noise levels have been reduced by 50% in comparison to the previous generation. The lower noise environment enhances problem-solving performance while boosting reliability and stability.
Increased Control Circuitry Precision: In the testing to date, the increased precision coupled with the noise reduction has demonstrated improved precision by up to 40%. To accomplish both while also improving manufacturing yield is a significant achievement.
Advanced Fabrication: The new processors comprise over 128,000 Josephson junctions (tunnel junctions with superconducting electrodes) in a 6-metal layer planar process with 0.25μm features, believed to be the most complex superconductor integrated circuits ever built.
New Modes of Use: The new technology expands the boundaries of ways to exploit quantum resources. In addition to performing discrete optimization like its predecessor, firmware and software upgrades will make it easier to use the system for sampling applications.
“Breaking the 1000 qubit barrier marks the culmination of years of research and development by our scientists, engineers and manufacturing team,” said D-Wave CEO Vern Brownell. “It is a critical step toward bringing the promise of quantum computing to bear on some of the most challenging technical, commercial, scientific, and national defense problems that organizations face.”
A June 20, 2015 article in The Economist notes there is now commercial interest as it provides good introductory information about quantum computing. The article includes an analysis of various research efforts in Canada (they mention D-Wave), the US, and the UK. These excerpts don’t do justice to the article but will hopefully whet your appetite or provide an overview for anyone with limited time,
A COMPUTER proceeds one step at a time. At any particular moment, each of its bits—the binary digits it adds and subtracts to arrive at its conclusions—has a single, definite value: zero or one. At that moment the machine is in just one state, a particular mixture of zeros and ones. It can therefore perform only one calculation next. This puts a limit on its power. To increase that power, you have to make it work faster.
But bits do not exist in the abstract. Each depends for its reality on the physical state of part of the computer’s processor or memory. And physical states, at the quantum level, are not as clear-cut as classical physics pretends. That leaves engineers a bit of wriggle room. By exploiting certain quantum effects they can create bits, known as qubits, that do not have a definite value, thus overcoming classical computing’s limits.
… The biggest question is what the qubits themselves should be made from.
A qubit needs a physical system with two opposite quantum states, such as the direction of spin of an electron orbiting an atomic nucleus. Several things which can do the job exist, and each has its fans. Some suggest nitrogen atoms trapped in the crystal lattices of diamonds. Calcium ions held in the grip of magnetic fields are another favourite. So are the photons of which light is composed (in this case the qubit would be stored in the plane of polarisation). And quasiparticles, which are vibrations in matter that behave like real subatomic particles, also have a following.
The leading candidate at the moment, though, is to use a superconductor in which the qubit is either the direction of a circulating current, or the presence or absence of an electric charge. Both Google and IBM are banking on this approach. It has the advantage that superconducting qubits can be arranged on semiconductor chips of the sort used in existing computers. That, the two firms think, should make them easier to commercialise.
Google is also collaborating with D-Wave of Vancouver, Canada, which sells what it calls quantum annealers. The field’s practitioners took much convincing that these devices really do exploit the quantum advantage, and in any case they are limited to a narrower set of problems—such as searching for images similar to a reference image. But such searches are just the type of application of interest to Google. In 2013, in collaboration with NASA and USRA, a research consortium, the firm bought a D-Wave machine in order to put it through its paces. Hartmut Neven, director of engineering at Google Research, is guarded about what his team has found, but he believes D-Wave’s approach is best suited to calculations involving fewer qubits, while Dr Martinis and his colleagues build devices with more.
It’s not clear to me if the writers at The Economist were aware of D-Wave’s latest breakthrough at the time of writing but I think not. In any event, they (The Economist writers) have included a provocative tidbit about quantum encryption,
Documents released by Edward Snowden, a whistleblower, revealed that the Penetrating Hard Targets programme of America’s National Security Agency was actively researching “if, and how, a cryptologically useful quantum computer can be built”. In May IARPA [Intellligence Advanced Research Projects Agency], the American government’s intelligence-research arm, issued a call for partners in its Logical Qubits programme, to make robust, error-free qubits. In April, meanwhile, Tanja Lange and Daniel Bernstein of Eindhoven University of Technology, in the Netherlands, announced PQCRYPTO, a programme to advance and standardise “post-quantum cryptography”. They are concerned that encrypted communications captured now could be subjected to quantum cracking in the future. That means strong pre-emptive encryption is needed immediately.
I encourage you to read the Economist article.
Two final comments. (1) The latest piece, prior to this one, about D-Wave was in a Feb. 6, 2015 posting about then new investment into the company. (2) A Canadian effort in the field of quantum cryptography was mentioned in a May 11, 2015 posting (scroll down about 50% of the way) featuring a profile of Raymond Laflamme, at the University of Waterloo’s Institute of Quantum Computing in the context of an announcement about science media initiative Research2Reality.
As of May 11, 2015, Canadians will be getting an addition to their science media environment (from the May 4, 2015 news release),
Research2Reality to celebrate Canadian research stars
Social media initiative to popularize scientific innovation
May 4, 2015, TORONTO – On Monday, May 11, Research2Reality.com goes live and launches a social media initiative that will make the scientist a star. Following in the footsteps of popular sites like IFLScience and How Stuff Works, Research2Reality uses a video series and website to engage the community in the forefront of scientific discoveries made here in Canada.
The interviews feature some of Canada’s leading researchers such as Dick Peltier – director of the Centre for Global Change Science at the University of Toronto, Sally Aitken – director of the Centre for Forest Conservation Genetics at the University of British Columbia and Raymond Laflamme – executive director of the Institute for Quantum Computing at the University of Waterloo.
“Right now many Canadians don’t understand the scope of cutting-edge work being done in our backyards,” says Research2Reality co-founder and award-winning professor Molly Shoichet. “This initiative will bridge that gap between researchers and the public.”
Also launching Monday, May 11, courtesy of Research2Reality’s official media partner, Discovery Science, is a complementary website www.sciencechannel.ca/Shows/Research2Reality. The new website will feature the exclusive premieres of a collection of interview sessions. In addition, Discovery Science and Discovery will broadcast an imaginative series of public service announcements through the end of the year, while social media accounts will promote Research2Reality, including Discovery’s flagship science and technology program DAILY PLANET.
Research2Reality is a social media initiative designed to popularize the latest Canadian research. It was founded by Molly Shoichet, Professor of Chemical Engineering & Applied Chemistry and Canada Research Chair in Tissue Engineering at the University of Toronto, and Mike MacMillan, founder and producer of Lithium Studios Productions. Research2Reality’s founding partners are leading research-intensive universities – the University of Alberta, the University of British Columbia, McMaster University, the University of Toronto, the University of Waterloo, and Western University – along with the Ontario Government and Discovery Networks. Discovery Science is the official media partner. Research2Reality is also supported by The Globe and Mail.
A Valentine of sorts to Canadian science researchers from Molly Shoichet (pronounced shoy [and] quette as in David Arquette) and her producing partner Mike MacMillan of Lithium Studios, Research2Reality gives Canadians an opportunity to discover online some of the extraordinary work done by scientists of all stripes, including (unusually) social scientists, in this country. The top tier in this effort is the interview video series ‘The Orange Chair Sessions‘ which can be found and shared across
Shoichet and MacMillan are convinced there’s an appetite for more comprehensive science information. Supporting The Orange Chair Sessions is a complementary website operated by Discovery Channel where there are
links to other resources
Discovery Channel is also going to be airing special one minute public service announcements (PSA) on topics like water, quantum computing, and cancer. Here’s one of the first of those PSAs,
“I’m very excited about this and really hope that other people will be too,” says Shoichet. The audience for the Research2Reality endeavour is for people who like to know more and have questions when they see news items about science discoveries that can’t be answered by investigating mainstream media programmes or trying to read complex research papers.
This is a big undertaking. ” Mike and I thought about this for about two years.” Building on the support they received from the University of Toronto, “We reached out to the vice-presidents of research at the top fifteen universities in the country.” In the end, six universities accepted the invitation to invest in this project,
the University of British Columbia,
the University of Alberta,
Western University (formerly the University of Western Ontario),
Waterloo University, and, of course,
the University of Toronto
(Unfortunately, Shoichet was not able to answer a question about the cost for an individual episode but perhaps when there’s time that detail and more about the financing will be made available. [ETA May 11, 2015 1625 PDT: Ivan Semeniuk notes this is a $400,000 project in his Globe and Mail May 11, 2015 article.]) As part of their involvement, the universities decide which of their researchers/projects should be profiled then Research2Reality swings into action. “We shoot our own video, that is, we (Mike and I) come out and conduct interviews that take approximately fifteen minutes. We also shoot a b-roll, that is, footage of the laboratories and other relevant sites so it’s not all ‘talking heads’.” Shoichet and MacMillan are interested in the answer to two questions, “What are you doing? and Why do we care?” Neither interviewer/producer is seen or heard on camera as they wanted to keep the focus on the researcher.
Three videos are being released initially with another 67 in the pipeline for a total of 70. The focus is on research of an international calibre and one of the first interviews to be released (Shoichet’s will be release later) is Raymond Laflamme’s (he’s also featured in the ‘quantum PSA’.
Who convinces a genius that he’s gotten an important cosmological concept wrong or ignored it? Alongside Don Page, Laflamme accomplished that feat as one of Stephen Hawking’s PhD students at the University of Cambridge. Today (May 11, 2015), Laflamme is (from his Wikipedia entry)
… co-founder and current director of the Institute for Quantum Computing at the University of Waterloo. He is also a professor in the Department of Physics and Astronomy at the University of Waterloo and an associate faculty member at Perimeter Institute for Theoretical Physics. Laflamme is currently a Canada Research Chair in Quantum Information.
Laflamme changed his focus from quantum cosmology to quantum information while at Los Alamos, “To me, it seemed natural. Not much of a change.” It is the difference between being a theoretician and an experimentalist and anyone who’s watched The Big Bang Theory (US television programme) knows that Laflamme made a big leap.
One of his major research interests is quantum cryptography, a means of passing messages you can ensure are private. Laflamme’s team and a team in Vienna (Austria) have enabled two quantum communication systems, one purely terrestrial version, which can exchange messages with another such system up to 100 km. away. There are some problems yet to be solved with terrestrial quantum communication. First, buildings, trees, and other structures provide interference as does the curvature of the earth. Second, fibre optic cables absorb some of the photons en route.
Satellite quantum communication seems more promising as these problems are avoided altogether. The joint Waterloo/Vienna team of researchers has conducted successful satellite experiments in quantum communication in the Canary Islands.
While there don’t seem to be any practical, commercial quantum applications, Laflamme says that isn’t strictly speaking the truth, “In the last 10 to 15 years many ideas have been realized.” The talk turns to quantum sensing and Laflamme mentions two startups and notes he can’t talk about them yet. But there is Universal Quantum Devices (UQD), a company that produces parts for quantum sensors. It is Laflamme’s startup, one he co-founded with two partners. (For anyone unfamiliar with the Canadian academic scene, Laflamme’s home institution, the University of Waterloo, is one of the most actively ‘innovative’ and business-oriented universities in Canada.)
LaFlamme’s interests extend beyond laboratory work and business. He’s an active science communicator as can be seen in this 2010 TEDxWaterloo presentation where he takes his audience from the discovery of fire to quantum physics concepts such as a ‘quantum superposition’ and the ‘observer effect’ to the question, ‘What is reality?’ in approximately 18 mins.
For anyone who needs a little more information, a quantum superposition is a term referring the ability of a quantum object to inhabit two states simultaneously, e.g., on/off. yes/no, alive/dead, as in Schrödinger’s cat. (You can find out more about quantum superpositions in this Wikipedia essay and about Schrodinger’s cat in this Wikipedia essay.) The observer effect is a phenomenon whereby the observer of a quantum experiment affects that experiment by the act of observing it. (You can find out more about the observer effect in this Wikipedia essay.)
The topic of reality is much trickier to explain. No one has yet been able to offer a viable theory for why the world at the macro scale behaves one way (classical physics) and the world at the quantum scale behaves another way (quantum physics). As Laflamme notes, “There is no such thing as a superposition in classical physics but we can prove in the laboratory that it exists in quantum physics.” He goes on to suggest that children, raised in an environment where quantum physics and its applications are commonplace, will have an utterly different notion as to what constitutes reality.
Laflamme is also interested in music and consulted on a ‘quantum symphony’. He has this to say about it in an Sept. 20, 2012 piece on the University of Waterlo website,
Science and art share a common goal — to help us understand our universe and ourselves. Research at IQC [Institute for Quantum Computing] aims to provide important new understanding of nature’s building blocks, and devise methods to turn that understanding into technologies beneficial for society.Since founding IQC a decade ago, I have sought ways to bridge science and the arts, with the belief that scientific discovery itself is a source of beauty and inspiration. Our collaboration with the Kitchener-Waterloo Symphony was an example — one of many yet to come — of how science and the arts provide different but complementary insights into our universe and ourselves.
From deep inside the sewers of Vienna, site of groundbreaking quantum teleportation experiments, to cutting-edge quantum computing labs, to voyages into the minds of the world’s brightest thinkers, including renowned British scientist Stephen Hawking, this documentary explores the coming quantum technological revolution.
All of this suggests an interest in science not seen since the 19th century when scientists could fill theatres for their lectures. Even Hollywood is capitalizing on this interest. Laflamme, who saw ‘Interstellar’, ‘The Imitation Game’ (Alan Turing), and ‘The Theory of Everything’ (Stephen Hawking) in fall 2014 comments, “I was surprised by how much science there was in The Imitation Game and Interstellar.” As for the Theory of Everything, “I was apprehensive since I know Stephen well. But, the actor, Eddie Redmayne, and the movie surprised me. There were times when he moved his head or did something in a particular way—he was Stephen. Also, most people don’t realize what an incredible sense of humour Stephen has and the movie captured that well.” Laflamme also observed that it was a movie about a relationship and not really concerned with science and its impacts (good and ill) or scientific accomplishments. Although he allows, “It could have had more science.”
Co-producer Shoichet has sterling scientific credentials of her own. In addition to this science communication project, she runs the Shoichet Lab at the University of Toronto (from the Dr. Molly Shoichet bio page),
Dr. Molly Shoichet holds the Tier 1 Canada Research Chair in Tissue Engineering and is University Professor of Chemical Engineering & Applied Chemistry, Chemistry and Biomaterials & Biomedical Engineering at the University of Toronto. She is an expert in the study of Polymers for Drug Delivery & Regeneration which are materials that promote healing in the body.
Dr. Shoichet has published over to 480 papers, patents and abstracts and has given over 310 lectures worldwide. She currently leads a laboratory of 25 researchers and has graduated 134 researchers over the past 20 years. She founded two spin-off companies from research in her laboratory.
Dr. Shoichet is the recipient of many prestigious distinctions and the only person to be a Fellow of Canada’s 3 National Academies: Canadian Academy of Sciences of the Royal Society of Canada, Canadian Academy of Engineering, and Canadian Academy of Health Sciences. Dr. Shoichet holds the Order of Ontario, Ontario’s highest honour and is a Fellow of the American Association for the Advancement of Science. In 2013, her contributions to Canada’s innovation agenda and the advancement of knowledge were recognized with the QEII Diamond Jubilee Award. In 2014, she was given the University of Toronto’s highest distinction, University Professor, a distinction held by less than 2% of the faculty.
MacMIllan’s biography (from the Lithium Studios website About section hints this is his first science-oriented series (Note: Links have been removed),
Founder of Lithium Studios Productions
University of Toronto (‘02)
UCLA’s Professional Producing Program (‘11)
His first feature, the dark comedy / thriller I Put a Hit on You (2014, Telefilm Canada supported), premiered at this year’s Slamdance Film Festival in Park City. Guidance (2014, Telefilm Canada supported, with super producer Alyson Richards over at Edyson), a dark comedy/coming of age story is currently in post-production, expected to join the festival circuit in September 2014.
Mike has produced a dozen short films with Toronto talents Dane Clark and Linsey Stewart (CAN – Long Branch, Margo Lily), Samuel Fluckiger (SWISS – Terminal, Nightlight) and Darragh McDonald (CAN – Love. Marriage. Miscarriage.). They’ve played at the top film fests around the world and won a bunch of awards.
Special skills include kickass hat collection and whiskey. Bam.
It’s nice to see the Canadian scene expanding; I’m particularly pleased to learn social scientists will be included.Too often researchers from the physical sciences or natural sciences and researchers from the social sciences remain aloof from each other. In April 2013, I attended a talk by Evelyn Fox Keller, physicist, feminist, and philosopher, who read from a paper she’d written based on a then relatively recent experience in South Africa where researchers had aligned themselves in two different groups and refused to speak to each other. They were all anthropologists but the sticking point was the type of science they practiced. One group were physical anthropologists and the other were cultural anthropologists. That’s an extreme example unfortunately symptomatic of a great divide. Bravo to Research2Reality for bringing the two groups together.
As for the science appetite Shoichet and MacMillan see in Canada, this is not the only country experiencing a resurgence of interest; they’ve been experiencing a science media expansion in the US. Neil deGrasse Tyson’s Star Talk television talk show, which also exists as a radio podcast, debuted on April 19, 2015 (Yahoo article by Calla Cofield); Public Radio Exchange’s (PRX) Transistor; a STEM (science, technology, engineering, and mathematics) audio project debuted in Feb. 2015; and video podcast Science Goes to the Movies also debuted in Feb. 2015 (more about the last two initiatives in my March 6, 2015 posting [scroll down about 40% of the way]). Finally (for the burgeoning US science media scene) and neither least nor new, David Bruggeman has a series of posts titled, Science and Technology Guests on Late Night, Week of …, on his Pasco Phronesis blog which has been running for many years. Bruggeman’s series is being included here because most people don’t realize that US late night talk shows have jumped into the science scene. You can check David’s site here as he posts this series on Mondays and this is Monday, May 11, 2015.
It’s early days for Research2Reality and it doesn’t yet have the depth one might wish. The videos are short (the one featured on the Discovery Channel’s complementary website is less than 2 mins. and prepare yourself for ads). They may not be satisfying from an information perspective but what makes The Orange Chair Series fascinating is the peek into the Canadian research scene. Welcome to Research2Reality and I hope to hear more about you in the coming months.
[ETA May 11, 2015 at 1625 PDT: Semeniuk’s May 11, 2015 article mentions a few other efforts to publicize Canadian research (Note: Links have been removed),
For example, Research Matters, a promotional effort by the Council of Ontario Universities, has built up a large bank of short articles on its website that highlight researchers across the province. Similarly, the Canada Foundation for Innovation, which channels federal dollars toward research infrastructure and projects, produces features stories with embedded videos about the scientists who are enabled by their investments.
What makes Research2Reality different, said Dr. Shoichet, is an approach that doesn’t speak for one region, field of research of [sic] funding stream.
One other aspect which distinguishes Research2Reality from the other science promotion efforts is the attempt to reach out to the audience. The Canada Foundation for Innovation and Council for Ontario Universities are not known for reaching out directly to the general public.]
There are three ‘eye’-related items in this piece, two of them concerning animal eyes and one concerning a camera-eye or the possibility of superhuman sight.
Earlier this week researchers at the University of Reading (UK) announced they have achieved a better understanding of how nanoparticles might be able to bypass some of the eye’s natural barriers in the hopes of making eye drops more effective in an Oct. 7, 2014 news item on Nanowerk,
Sufferers of eye disorders have new hope after researchers at the University of Reading discovered a potential way of making eye drops more effective.
Typically less than 5% of the medicine dose applied as drops actually penetrates the eye – the majority of the dose will be washed off the cornea by tear fluid and lost.
The team, led by Professor Vitaliy Khutoryanskiy, has developed novel nanoparticles that could attach to the cornea and resist the wash out effect for an extended period of time. If these nanoparticles are loaded with a drug, their longer attachment to the cornea will ensure more medicine penetrates the eye and improves drop treatment.
The research could also pave the way for new treatments of currently incurable eye-disorders such as Age-related Macular Degeneration (AMD) – the leading cause of visual impairment with around 500,000 sufferers in the UK.
There is currently no cure for this condition but experts believe the progression of AMD could be slowed considerably using injections of medicines into the eye. However, eye-drops with drug-loaded nanoparticles could be a potentially more effective and desirable course of treatment.
Professor Vitaliy Khutoryanskiy, from the University of Reading’s School of Pharmacy, said: “Treating eye disorders is a challenging task. Our corneas allow us to see and serve as a barrier that protects our eyes from microbial and chemical intervention. Unfortunately this barrier hinders the effectiveness of eye drops. Many medicines administered to the eye are inefficient as they often cannot penetrate the cornea barrier. Only the very small molecules in eye drops can penetrate healthy cornea.
“Many recent breakthroughs to treat eye conditions involve the use of drugs incorporated into nano-containers; their role being to promote drug penetration into the eye. However the factors affecting this penetration remain poorly understood. Our research also showed that penetration of small drug molecules could be improved by adding enhancers such as cyclodextrins. This means eye drops have the potential to be a more effective, and a more comfortable, future treatment for disorders such as AMD.”
The finding is one of a number of important discoveries highlighted in a paper published today in the journal Molecular Pharmaceutics. The researchers revealed fascinating insights into how the structure of the cornea prevents various small and large molecules, as well as nanoparticles, from entering into the eye. They also examined the effects any damage to the eye would have in allowing these materials to enter the body.
Professor Khutoryanskiy continued: “There is increasing concern about the safety of environmental contaminants, pollutants and nanoparticles and their potential impacts on human health. We tested nanoparticles whose sizes ranged between 21 – 69 nm, similar to the size of viruses such as polio, or similar to airborn particles originating from building industry and found that they could not penetrate healthy and intact cornea irrespective of their chemical nature.
“However if the top layer of the cornea is damaged, either after surgical operation or accidentally, then the eye’s natural defence may be compromised and it becomes susceptible to viral attack which could result in eye infections.
“The results show that our eyes are well-equipped to defend us against potential airborne threats that exist in a fast-developing industrialised world. However we need to be aware of the potential complications that may arise if the cornea is damaged, and not treated quickly and effectively.”
There’s a little more information to be had in the paper’s abstract, which is, as these things go, is relatively accessible,
[downloaded from http://pubs.acs.org/doi/abs/10.1021/mp500332m]
Overcoming the natural defensive barrier functions of the eye remains one of the greatest challenges of ocular drug delivery. Cornea is a chemical and mechanical barrier preventing the passage of any foreign bodies including drugs into the eye, but the factors limiting penetration of permeants and nanoparticulate drug delivery systems through the cornea are still not fully understood. In this study, we investigate these barrier properties of the cornea using thiolated and PEGylated (750 and 5000 Da) nanoparticles, sodium fluorescein, and two linear polymers (dextran and polyethylene glycol). Experiments used intact bovine cornea in addition to bovine cornea de-epithelialized or tissues pretreated with cyclodextrin. It was shown that corneal epithelium is the major barrier for permeation; pretreatment of the cornea with β-cyclodextrin provides higher permeation of low molecular weight compounds, such as sodium fluorescein, but does not enhance penetration of nanoparticles and larger molecules. Studying penetration of thiolated and PEGylated (750 and 5000 Da) nanoparticles into the de-epithelialized ocular tissue revealed that interactions between corneal surface and thiol groups of nanoparticles were more significant determinants of penetration than particle size (for the sizes used here). PEGylation with polyethylene glycol of a higher molecular weight (5000 Da) allows penetration of nanoparticles into the stroma, which proceeds gradually, after an initial 1 h lag phase.
The paper is behind a paywall. No mention is made in the abstract or in the press release as to how the bovine (ox, cow, or buffalo) eyes were obtained but I gather these body parts are often harvested from animals that have been previously slaughtered for food.
This next item also concerns research about eye drops but this time the work comes from the University of Waterloo (Ontario, Canada). From an Oct. 8, 2014 news item on Azonano,
For the millions of sufferers of dry eye syndrome, their only recourse to easing the painful condition is to use drug-laced eye drops three times a day. Now, researchers from the University of Waterloo have developed a topical solution containing nanoparticles that will combat dry eye syndrome with only one application a week.
The eye drops progressively deliver the right amount of drug-infused nanoparticles to the surface of the eyeball over a period of five days before the body absorbs them. One weekly dose replaces 15 or more to treat the pain and irritation of dry eyes.
The nanoparticles, about 1/1000th the width of a human hair, stick harmlessly to the eye’s surface and use only five per cent of the drug normally required.
“You can’t tell the difference between these nanoparticle eye drops and water,” said Shengyan (Sandy) Liu, a PhD candidate at Waterloo’s Faculty of Engineering, who led the team of researchers from the Department of Chemical Engineering and the Centre for Contact Lens Research. “There’s no irritation to the eye.”
Dry eye syndrome is a more common ailment for people over the age of 50 and may eventually lead to eye damage. More than six per cent of people in the U.S. have it. Currently, patients must frequently apply the medicine three times a day because of the eye’s ability to self-cleanse—a process that washes away 95 per cent of the drug.
“I knew that if we focused on infusing biocompatible nanoparticles with Cyclosporine A, the drug in the eye drops, and make them stick to the eyeball without irritation for longer periods of time, it would also save patients time and reduce the possibility of toxic exposure due to excessive use of eye drops,” said Liu.
The research team is now focusing on preparing the nanoparticle eye drops for clinical trials with the hope that this nanoparticle therapy could reach the shelves of drugstores within five years.
This paper is behind a paywall. There is a partial preview available for free. As per the paper’s abstract, research was performed on healthy rabbit eyes.
The last ‘sight’ item I’m featuring here comes from the Massachusetts Institute of Technology (MIT) and does not appear to have been occasioned by the publication of a research paper or some other event. From an Oct. 7, 2014 news item on Azonano,
All through his childhood, Ramesh Raskar wished fervently for eyes in the back of his head. “I had the notion that the world did not exist if I wasn’t looking at it, so I would constantly turn around to see if it was there behind me.” Although this head-spinning habit faded during his teen years, Raskar never lost the desire to possess the widest possible field of vision.
Today, as director of the Camera Culture research group and associate professor of Media Arts and Sciences at the MIT Media Lab, Raskar is realizing his childhood fantasy, and then some. His inventions include a nanocamera that operates at the speed of light and do-it-yourself tools for medical imaging. His scientific mission? “I want to create not just a new kind of vision, but superhuman vision,” Raskar says.
He avoids research projects launched with a goal in mind, “because then you only come up with the same solutions as everyone else.” Discoveries tend to cascade from one area into another. For instance, Raskar’s novel computational methods for reducing motion blur in photography suggested new techniques for analyzing how light propagates. “We do matchmaking; what we do here can be used over there,” says Raskar.
Inspired by the famous microflash photograph of a bullet piercing an apple, created in 1964 by MIT professor and inventor Harold “Doc” Edgerton, Raskar realized, “I can do Edgerton millions of times faster.” This led to one of the Camera Culture group’s breakthrough inventions, femtophotography, a process for recording light in flight.
Manipulating photons into a packet resembling Edgerton’s bullet, Raskar and his team were able to “shoot” ultrashort laser pulses through a Coke bottle. Using a special camera to capture the action of these pulses at half a trillion frames per second with two-trillionths of a second exposure times, they captured moving images of light, complete with wave-like shadows lapping at the exterior of the bottle.
Femtophotography opened up additional avenues of inquiry, as Raskar pondered what other features of the world superfast imaging processes might reveal. He was particularly intrigued by scattered light, the kind in evidence when fog creates the visual equivalent of “noise.”
In one experiment, Raskar’s team concealed an object behind a wall, out of camera view. By firing super-short laser bursts onto a surface nearby, and taking millions of exposures of light bouncing like a pinball around the scene, the group rendered a picture of the hidden object. They had effectively created a camera that peers around corners, an invention that might someday help emergency responders safely investigate a dangerous environment.
Raskar’s objective of “making the invisible visible” extends as well to the human body. The Camera Culture group has developed a technique for taking pictures of the eye using cellphone attachments, spawning inexpensive, patient-managed vision and disease diagnostics. Conventional photography has evolved from time-consuming film development to instantaneous digital snaps, and Raskar believes “the same thing will happen to medical imaging.” His research group intends “to break all the rules and be at the forefront. I think we’ll get there in the next few years,” he says.
Ultimately, Raskar predicts, imaging will serve as a catalyst of transformation in all dimensions of human life — change that can’t come soon enough for him. “I hate ordinary cameras,” he says. “They record only what I see. I want a camera that gives me a superhuman perspective.”
Following the link to the MIT news release will lead you to more information about Raskar and his work. You can also see and hear Raskar talk about his femtophotography in a 2012 TEDGlobal talk here.
The ‘International Symposium on Nanoscience and Nanotechnology’ will be hosted at The University of the West Indies (UWI), St. Augustine [in Trinidad and Tobago], from July 15-17, 2014. The symposium, focused on the frontier areas of science, medicine and technology, is the first of its kind in the English-speaking Caribbean and is organised jointly by CARISCIENCE, The UWI and the University of Trinidad and Tobago. The symposium consists of a Public Lecture on Day 1 and Scientific Sessions over Days 2 and 3.
This international symposium is important and ground-breaking since these are widely viewed as revolutionary fields. Nanoscience and nanotechnology are considered to have huge potential to bring benefits to many areas of research and application and are attracting rapidly increasing investments from governments and businesses in many parts of the world.
Despite developments in nanoscience and nanotechnology, the Caribbean as a region has not been involved to the extent that more advanced countries have. As such, this symposium aims to provide a stronger focus on the impact and implications of developments in nanoscience/nanotechnology for stakeholders within the Caribbean region, including researchers, academics, university students, government and policy makers, industry partners and the wider public. The symposium will explore various topics under the following themes:
Nanotechnology for Sustainable Energy and Industrial Applications
Nanotechnology for Electronic Device and Sensor Applications
Nanotechnology in Biology, Medicine and Pharmaceuticals
Nanoscale Synthesis, Nanofabrication and Characterization
An impressive line-up of leading, globally recognised experts from world-class international and regional institutes awaits, including the Public Lecture titled “Science and the Elements of Daily Life,” to be delivered by world-renowned scientist, Professor Anthony K. Cheetham FRS, University of Cambridge, Vice President and Treasurer of The Royal Society. Additionally, the Keynote Address at the Opening Ceremony will be delivered by The Right Honourable Keith Mitchell, Prime Minister of Grenada, with responsibility for Science and Technology in CARICOM.
Speakers at the scientific sessions include Professor Fidel Castro Díaz-Balart (Scientific Advisor to the President of the Republic of Cuba and Vice President of The Academy of Science, Cuba); Professor Frank Gu (University of Waterloo, Canada); Professor Christopher Backhouse (former Director of the Waterloo Institute of Nanotechnology, University of Waterloo, Canada); Professor G. U. Kulkarni (JNCASR, India) and Professor Masami Okamoto (Toyota Technology Institute, Japan).
Students, teachers, academics and the wider public, are all invited and encouraged to attend and use this unique opportunity to engage these leading scientists.
The free Public Lecture is scheduled for Tuesday July 15, 2014, from 5pm-7.30pm, at the Daaga Auditorium, The UWI, St. Augustine Campus. [emphasis mine] The Scientific Sessions take place on Wednesday and Thursday July 16 and 17, 2014, from 8.30am-5pm, at Lecture Theatre A1, UWI Teaching and Learning Complex, Circular Road, St. Augustine. There will also be a small Poster Session to highlight some research done in the areas of Nanoscience and nanotechnology in the Caribbean.
All attendees (to the scientific sessions) must complete and send registration forms to the email address email@example.com by Sunday, July 13, 2014. Registration forms may be downloaded at the Campus Events Calendar entry by visiting www.sta.uwi.edu/news/ecalendar.
A registration fee must be paid in cash at the registration desk on Wednesday July 16, 2014, Day 2, at the start of the scientific sessions.