Tag Archives: US

Nanotechnology announcements: a new book and a new report

Two quick announcements. The first concerns a forthcoming book to be published in March 2015. Titled, Nanotechnology Law & Guidelines: A Practical Guide for the Nanotechnology Industries in Europe, the book is featured in an Aug. 15, 2014 news item on Nanowerk,

The book is a concise guideline to different issues of nanotechnology in the European Legislation.- It offers an extensive review of all European Patent Office (EPO) cases on nanotechnological inventions. The challenge for new nanotechnology patents is to determine how patent criteria could be met in a patent application. This book shows how to identify the approach and the ways to cope with this challenge.

More about the book and purchasing options can be found on the publisher’s (Springer) Nanotechnology Law & Guidelines webpage,

[Table of Contents:]

Introduction.- Part I Nanotechnology from Research to Manufacture: The legal framework of the nanotechnology research and development.- Structuring the research and development of nanotechnologies.- Manufacturing nanotechnologies.-

Part II Protecting Nanotechnological Inventions: A Matter of Strategy : Trade Secrets vs. Patents and Utility Models.- Trade Secrets and Nanotechnologies.- International, European or National Patent for Nanotechnological Inventions ?- Nanotechnology Patents and Novelty.- Nanotechnology Patents and the Inventive Step.- Nanotechnology Patents and the Industrial Application.- Drafting Nanotechnology Patents Applications.- Utility Models as Alternative Means for Protecting Nanotechnological Inventions.- Copyright, Databases and Designs in the Nano Industry.- Managing and Transferring Nanotechnology Intellectual Property.-

Part III Nanotechnologies Investment and Finance.- Corporate Law and the nanotechnology industry.- Tax Law for the nanotechnology industry.- Investing and financing a nanotechnological project.-

Part IV Marketing Nanotechnologies.- Authorization and Registration Systems.- Product Safety and Liability.- Advertising “Nano”.- “Nano” Trademarks.- Importing and Exporting Nanotechnologies. Annexes: Analytic Table of EPO Cases on Nanotechnologies.- Analytic Table of National Cases on Nanotechnologies.- Analytic Table of OHIM Cases on Nano Trademarks.

I was able to find some information about the author, Anthony Bochon on his University of Stanford (where he is a Fellow) biography page,

Anthony Bochon is an associate in a Brussels-based law firm, an associate lecturer in EU Law & Trade Law/IP Law at the Université libre de Bruxelles and a lecturer in EU Law at the Brussels Business Institute. He is an associate researcher at the unit of Economic Law of the Faculty of Law of the Université libre de Bruxelles. Anthony graduated magna cum laude from the Université libre de Bruxelles in 2010 and received a year later an LL.M. from the University of Cambridge where he studied EU Law, WTO Law and IP Law. He has published on topics such as biotechnological patents, EU trade law and antitrust law since 2008. Anthony is also the author of the first European website devoted to the emerging legal area of nanotechnology law, a field about which he writes frequently and speaks regularly at international conferences. His legal practice is mainly focussed on EU Law, competition law and regulatory issues and he has a strong and relevant experience in IP/IT Law. He devotes his current research to EU and U.S. trade secrets law. Anthony has been a TTLF Fellow since June 2013.

On a completely other note and in the more recent future, there’s a report about the US National Nanotechnology Initiative to be released Aug. 28, 2014 as per David Bruggeman’s Aug. 14. 2014 posting on his Pasco Phronesis blog, (Note: A link has been removed)

On August 28 PCAST [President's Council of Advisors on Science and Technology] will hold a public conference call in connection with the release of two new reports.  One will be a review of the National Nanotechnology Initiative (periodically required by law) … .

The call runs from 11:45 a.m. to 12:30 p.m. Eastern.  Registration is required, and closes at noon Eastern on the 26th..

That’s it for nanotechnology announcements today (Aug. 15, 2014).

I know something about your mummy or an ion beam microscope analyses a sarcophagus scrap

“Bearded Man, 170-180 A.D.” from the Walters Art Museum collection, object #32.6

“Bearded Man, 170-180 A.D.” from the Walters Art Museum collection, object #32.6

An Aug. 14, 2014 news item on Azonano describing this image sparks the imagination,

He looks almost Byzantine or Greek, gazing doe-eyed over the viewer’s left shoulder, his mouth forming a slight pout, like a star-struck lover or perhaps a fan of the races witnessing his favorite charioteer losing control of his horses.

In reality, he’s the “Bearded Man, 170-180 A.D.,” a Roman-Egyptian whose portrait adorned the sarcophagus sheltering his mummified remains. But the details of who he was and what he was thinking have been lost to time.

But perhaps not for much longer. A microscopic sliver of painted wood could hold the keys to unraveling the first part of this centuries-old mystery. Figuring out what kind of pigment was used (whether it was a natural matter or a synthetic pigment mixed to custom specifications), and the exact materials used to create it, could help scientists unlock his identity.

Kathleen Tuck’s Aug. 13 (?), 2014 Boise State University (Idaho, US) news release, which originated the news item, describes the nature of the research and the difficulties associated with it,

“Understanding the pigment means better understanding of the provenance of the individual” said Darryl Butt, a Boise State distinguished professor in the Department of Materials Science and Engineering and associate director of the Center for Advanced Energy Studies (CAES). “Where the pigment came from may connect it to a specific area and maybe even a family.”

For years, researchers were limited by the lack of samples large enough to be properly analyzed. But advances in the field of nanotechnology mean scientists now can work with fragments tinier than the eye can even register. Using a $1.5 million ion beam microscope at CAES, Butt — along with CAES colleagues Yaqaio Wu and Jatu Burns, and Boise State student researchers Gordon Alanko and Jennifer Watkins — is working with a sliver of the wood portrait smaller than a human hair.

The team transferred the fragment to a sample holder using a tiny deer hair called an “eyelash.” Their biggest challenge was to move it to the equipment without losing it.

So far they have extracted five needle-tip sized fragments 20 nanometers wide (a nanometer is a billionth of a meter), as well as two thin foils. From that, they have been able to analyze and map out the chemistry of the material in three dimensions.

Butt and his team are analyzing a speck of purple paint, which is significant because the blue used to blend the purple hue was a precious pigment back in the day, signaling a prominent individual.

This research is part of a larger project (from the news release),

Their data is being analyzed by researchers from the Detroit Museum of Art, where a companion to the “Bearded Man” mummy resides. It’s part of a project, titled APPEAR (Ancient Panel Paintings-Examination, Analysis, Research), a collaboration between 12 museums, including the British Museum in London and the Walters Art Museum in Baltimore, Maryland.

According to the news release there’s a personal aspect to Butt’s interest in this research, which may eventually have implications for Boise State University’s programmes,

“So far we’ve learned that the paint is a synthetic pigment,” said Butt, who as an artist in his own right often mixes his own pigments for his paintings. “These are very vibrant pigments, possibly heated in a lead crucible. People thought that process had been developed in the 1800s or so. This could prove it happened a lot earlier.

Butt got into solving art mysteries when he met Glenn Gates, a conservation scientist at the Walters Art Museum [Baltimore, Maryland] at a conference at Stanford University [California]. Both are officers of a new section of the American Ceramic Society — the Art, Archaeology and Conservation Science division.

“This research was a gamble that we [materials scientists] could do some really cool stuff,” Butt said, noting that he would love to branch out into analyzing pottery and other ancient artifacts.

While studying the provenance of Roman-Egyptian mummies is something new at Boise State, many researchers in the art, geology, history, anthropology and even English departments are involved in what Butt likes to call ‘reverse engineering’ of objects of cultural heritage.

“This particular problem, that is of understanding a particle of pigment from a 2,000-year-old sarcophagus, is a bit unique in that it highlights some of the amazing tools that we have at Boise State and at CAES that could shed new light on problems associated with understanding human history,” he said.

Butt hopes that these and similar transdisciplinary projects will open up external research opportunities for students, including creation of a “pipeline” of students who travel to various user facilities or museums to carry out interdisciplinary research.

“Envision, for example, art students studying works of art using synchrotron radiation and bright x-rays at a national laboratory, while science and engineering students use their technical skills to unravel mysteries of materials used by ancient societies in the field or held by museums,” he said.

The idea can sound far-fetched even for those who are participating in the research, although there is a certain, sound logic to transdisciplinary work between the arts and the sciences.

I was not able to find any reference to Butt’s art work online, find a published research paper or more information (website) featuring APPEAR ((Ancient Panel Paintings-Examination, Analysis, Research); admittedly, it was a brief search.

There are many techniques used to examine works of art and/or heritage. For a description of another technique, Raman spectroscopy, and its use in examining art pigments there’s my June 27, 2014 posting titled: Art (Lawren Harris and the Group of Seven), science (Raman spectroscopic examinations), and other collisions at the 2014 Canadian Chemistry Conference (part 2 of 4). Should you be interested in the entire series, additional links can be found in that posting.

Two-organ tests (body-on-a-chip) show liver damage possible from nanoparticles

This is the first time I’ve seen testing of two organs for possible adverse effects from nanoparticles. In this case, the researchers were especially interested in the liver. From an Aug. 12, 2014 news item on Azonano,

Nanoparticles in food, sunscreen and other everyday products have many benefits. But Cornell [University] biomedical scientists are finding that at certain doses, the particles might cause human organ damage.

A recently published study in Lab on a Chip by the Royal Society of Chemistry and led by senior research associate Mandy Esch shows that nanoparticles injure liver cells when they are in microfluidic devices designed to mimic organs of the human body. The injury was worse when tested in two-organ systems, as opposed to single organs – potentially raising concerns for humans and animals.

Anne Ju’s Aug. 11, 2014 article for Cornell University’s Chronicle describes the motivation for this work and the research itself in more detail,

“We are looking at the effects of what are considered to be harmless nanoparticles in humans,” Esch said. “These particles are not necessarily lethal, but … are there other consequences? We’re looking at the non-lethal consequences.”

She used 50-nanometer carboxylated polystyrene nanoparticles, found in some animal food sources and considered model inert particles. Shuler’s lab specializes in “body-on-a-chip” microfluidics, which are engineered chips with carved compartments that contain cell cultures to represent the chemistry of individual organs.

In Esch’s experiment, she made a human intestinal compartment, a liver compartment and a compartment to represent surrounding tissues in the body. She then observed the effects of fluorescently labeled nanoparticles as they traveled through the system.

Esch found that both single nanoparticles as well as small clusters crossed the gastrointestinal barrier and reached liver cells, and the liver cells released an enzyme called aspartate transaminase, known to be released during cell death or damage.

It’s unclear exactly what damage is occurring or why, but the results indicate that the nanoparticles must be undergoing changes as they cross the gastrointestinal barrier, and that these alterations may change their toxic potential, Esch said. Long-term consequences for organs in proximity could be a concern, she said.

“The motivation behind this study was twofold: one, to show that multi-organ, in vitro systems give us more information when testing for the interaction of a substance with the human body, and two … to look at nanoparticles because they have a huge potential for medicine, yet adverse effects have not been studied in detail yet,” Esch said.

Mary Macleod’s July 3, 2014 article for Chemistry World features a diagram of the two-organ system and more technical details about the research,

Schematic of the two-organ system [downloaded from http://www.rsc.org/chemistryworld/2014/07/nanoparticle-liver-gastrointestinal-tract-microfluidic-chip]

Schematic of the two-organ system [downloaded from http://www.rsc.org/chemistryworld/2014/07/nanoparticle-liver-gastrointestinal-tract-microfluidic-chip]

HepG2/C3A cells were used to represent the liver, with the intestinal cell co-culture consisting of enterocytes (Caco-2) and mucin-producing (HT29-MTX) cells. Carboxylated polystyrene nanoparticles were fluorescently labelled so their movement between the chambers could be tracked. Levels of aspartate transaminase, a cytosolic enzyme released into the culture medium upon cell death, were measured to give an indication of liver damage.

The study saw that single nanoparticles and smaller nanoparticle aggregates were able to cross the GI barrier and reach the liver cells. The increased zeta potentials of these nanoparticles suggest that crossing the barrier may raise their toxic potential. However, larger nanoparticles, which interact with cell membranes and aggregate into clusters, were stopped much more effectively by the GI tract barrier.

The gastrointestinal tract is an important barrier preventing ingested substances crossing into systemic circulation. Initial results indicate that soluble mediators released upon low-level injury to liver cells may enhance the initial injury by damaging the cells which form the GI tract. These adverse effects were not seen in conventional single-organ tests.

Here’s a link to and a citation for the paper,

Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury by Mandy B. Esch, Gretchen J. Mahler, Tracy Stokol, and Michael L. Shuler. Lab Chip, 2014,14, 3081-3092 DOI: 10.1039/C4LC00371C First published online 27 Jun 2014

This paper is open access until Aug. 12, 2014.

While this research is deeply concerning, it should be noted the researchers are being very careful in their conclusions as per Ju’s article, “It’s unclear exactly what damage is occurring or why, but the results indicate that the nanoparticles must be undergoing changes as they cross the gastrointestinal barrier, and that these alterations may change their toxic potential … Long-term consequences for organs in proximity could be a concern … .”

Graphene and an artificial retina

A graphene-based artificial retina project has managed to intermingle the European Union’s two major FET (Future and Emerging Technologies) funding projects, 1B Euros each to be disbursed over 10 years, the Graphene Flagship and the Human Brain Project. From an Aug. 7, 2014 Technische Universitaet Muenchen (TUM) news release (also on EurekAlert),

Because of its unusual properties, graphene holds great potential for applications, especially in the field of medical technology. A team of researchers led by Dr. Jose A. Garrido at the Walter Schottky Institut of the TUM is taking advantage of these properties. In collaboration with partners from the Institut de la Vision of the Université Pierre et Marie Curie in Paris and the French company Pixium Vision, the physicists are developing key components of an artificial retina made of graphene.

Retina implants can serve as optical prostheses for blind people whose optical nerves are still intact. The implants convert incident light into electrical impulses that are transmitted to the brain via the optical nerve. There, the information is transformed into images. Although various approaches for implants exist today, the devices are often rejected by the body and the signals transmitted to the brain are generally not optimal.

Already funded by the Human Brain Project as part of the Neurobotics effort, Garrido and his colleagues will now also receive funding from the Graphene Flagship. As of July 2014, the Graphene Flagship has added 86 new partners including TUM according to the news release.

Here’s an image of an ‘invisible’ graphene sensor (a precursor to developing an artificial retina),

Graphene electronics can be prepared on flexible substrates. Only the gold metal leads are visible in the transparent graphene sensor. (Photo: Natalia Hutanu / TUM)

Graphene electronics can be prepared on flexible substrates. Only the gold metal leads are visible in the transparent graphene sensor. (Photo: Natalia Hutanu / TUM)

Artificial retinas were first featured on this blog in an Aug. 18, 2011 posting about video game Deus Ex: Human Revolution which features a human character with artificial sight. The post includes links to a video of a scientist describing an artificial retina trial with 30 people and an Israeli start-up company, ‘Nano Retina’, along with information about ‘Eyeborg’, a Canadian filmmaker who on losing an eye in an accident had a camera implanted in the previously occupied eye socket.

More recently, a Feb. 15, 2013 posting featured news about the US Food and Drug Administration’s decision to allow sale of the first commercial artificial retinas in the US in the context of news about a neuroprosthetic implant in a rat which allowed it to see in the infrared range, normally an impossible feat.

Cyborgs (a presentation) at the American Chemical Society’s 248th meeting

There will be a plethora of chemistry news online over the next few days as the American Society’s (ACS) 248th meeting in San Francisco, CA from Aug. 10 -14, 2014 takes place. Unexpectedly, an Aug. 11, 2014 news item on Azonano highlights a meeting presentation focused on cyborgs,

No longer just fantastical fodder for sci-fi buffs, cyborg technology is bringing us tangible progress toward real-life electronic skin, prosthetics and ultraflexible circuits. Now taking this human-machine concept to an unprecedented level, pioneering scientists are working on the seamless marriage between electronics and brain signaling with the potential to transform our understanding of how the brain works — and how to treat its most devastating diseases.

An Aug. 10, 2014 ACS news release on EurekAlert provides more detail about the presentation (Note: Links have been removed),

“By focusing on the nanoelectronic connections between cells, we can do things no one has done before,” says Charles M. Lieber, Ph.D. “We’re really going into a new size regime for not only the device that records or stimulates cellular activity, but also for the whole circuit. We can make it really look and behave like smart, soft biological material, and integrate it with cells and cellular networks at the whole-tissue level. This could get around a lot of serious health problems in neurodegenerative diseases in the future.”

These disorders, such as Parkinson’s, that involve malfunctioning nerve cells can lead to difficulty with the most mundane and essential movements that most of us take for granted: walking, talking, eating and swallowing.

Scientists are working furiously to get to the bottom of neurological disorders. But they involve the body’s most complex organ — the brain — which is largely inaccessible to detailed, real-time scrutiny. This inability to see what’s happening in the body’s command center hinders the development of effective treatments for diseases that stem from it.

By using nanoelectronics, it could become possible for scientists to peer for the first time inside cells, see what’s going wrong in real time and ideally set them on a functional path again.

For the past several years, Lieber has been working to dramatically shrink cyborg science to a level that’s thousands of times smaller and more flexible than other bioelectronic research efforts. His team has made ultrathin nanowires that can monitor and influence what goes on inside cells. Using these wires, they have built ultraflexible, 3-D mesh scaffolding with hundreds of addressable electronic units, and they have grown living tissue on it. They have also developed the tiniest electronic probe ever that can record even the fastest signaling between cells.

Rapid-fire cell signaling controls all of the body’s movements, including breathing and swallowing, which are affected in some neurodegenerative diseases. And it’s at this level where the promise of Lieber’s most recent work enters the picture.

In one of the lab’s latest directions, Lieber’s team is figuring out how to inject their tiny, ultraflexible electronics into the brain and allow them to become fully integrated with the existing biological web of neurons. They’re currently in the early stages of the project and are working with rat models.

“It’s hard to say where this work will take us,” he says. “But in the end, I believe our unique approach will take us on a path to do something really revolutionary.”

Lieber acknowledges funding from the U.S. Department of Defense, the National Institutes of Health and the U.S. Air Force.

I first covered Lieber’s work in an Aug. 27, 2012 posting  highlighting some good descriptions from Lieber and his colleagues of their work. There’s also this Aug. 26, 2012 article by Peter Reuell in the Harvard Gazette (featuring a very good technical description for someone not terribly familiar with the field but able to grasp some technical information while managing their own [mine] ignorance). The posting and the article provide details about the foundational work for Lieber’s 2014 presentation at the ACS meeting.

Lieber will be speaking next at the IEEE (Institute for Electrical and Electronics Engineers) 14th International Conference on Nanotechnology sometime between August 18 – 21, 2014 in Toronto, Ontario, Canada.

As for some of Lieber’s latest published work, there’s more information in my Feb. 20, 2014 posting which features a link to a citation for the paper (behind a paywall) in question.

It’s an ‘Alice in Wonderland’ world where a particle can be separated from its properties

In a joint research project, French, Austrians, and American researchers have achieved a state described in Lewis Carroll’s well loved story, Alice in Wonderland. (Three of the four institutions involved have issued news releases, as this is the only one to feature a quote from Alice in Wonderland describing the state, it gets mentioned first.) From a July 29, 2014 Chapman University news release on EurekAlert,

… “Well! I’ve often seen a cat without a grin,” thought Alice in Wonderland, “but a grin without a cat! It’s the most curious thing I ever saw in my life!” Alice’s surprise stems from her experience that an object and its property cannot exist independently. It seems to be impossible to find a grin without a cat. However, the strange laws of quantum mechanics (the theory which governs the microscopic world of atoms; and the most successful theory in history) tell us that it is indeed possible to separate a particle from its properties—a phenomenon which is strikingly analogous to the Cheshire Cat story. The quantum Cheshire Cat is the latest example of how strange quantum mechanics becomes when viewed through the lens of one of Aharonov’s fundamental discoveries called the “weak measurement.”

Modesty does not favour contemporary research and educational institutions and, as is common in situations where there’s significant scientific excitement with a number of collaborators, the cooperating institutions are angling to establish the importance of their institutions and/or researchers’ contributions.

Here’s more from the Chapman  University news release where it establishes its claim to the theory,

The idea of the Quantum Cheshire Cat was first discovered by Chapman’s Prof. Yakir Aharonov and first published by Aharonov’s collaborator, Prof. Jeff Tollaksen (also at Chapman University), in 2001. Aharonov’s team, including Sandu Popescu (University of Bristol and Chapman’s Institute for Quantum Studies) and Daniel Rorhlich (Ben Gurion University), continued to develop the Cheshire Cat theory in more recent publications.

A July 29, 2014 Vienna University of Technology news release on EurekAlert provides this description and its claim to inventing the technique used in the latest experimental work,

According to the law of quantum physics, particles can be in different physical states at the same time. If, for example, a beam of neutrons is divided into two beams using a silicon crystal, it can be shown that the individual neutrons do not have to decide which of the two possible paths they choose. Instead, they can travel along both paths at the same time in a quantum superposition.

“This experimental technique is called neutron interferometry”, says Professor Yuji Hasegawa from the Vienna University of Technology. “It was invented here at our institute in the 1970s, and it has turned out to be the perfect tool to investigate fundamental quantum mechanics.”

A July 29, 2014 Institut Laue-Langevin (international research institute located in Grenoble, France) news release on EurekAlert establishes its claim as the location for the experimental work,

Researchers from the Vienna University of Technology have performed the first separation of a particle from one of its properties. The study, carried out at the Institute Laue-Langevin (ILL) and published in Nature Communications, showed that in an interferometer a neutron’s magnetic moment could be measured independently of the neutron itself, thereby marking the first experimental observation of a new quantum paradox known as the ‘Cheshire Cat’. The new technique, which can be applied to any property of any quantum object, could be used to remove disturbance and improve the resolution of high precision measurements.

The fourth collaborating institution (l’Université de Cergy-Pontoise) does not seem to have issued a news release in either French or English as per my August 8, 2014 searches.

The research itself is quite fascinating and it’s worth reading all three news releases for additional nuggets information hidden amongst the repetitive bits. Here’s a description you’ll find in both the Vienna University of Technology and Chapman University news releases,

Neutrons are not electrically charged, but they carry a magnetic moment. They have a magnetic direction, the neutron spin, which can be influenced by external magnetic fields.

First, a neutron beam is split into two parts in a neutron interferometer. Then the spins of the two beams are shifted into different directions: The upper neutron beam has a spin parallel to the neutrons’ trajectory, the spin of the lower beam points into the opposite direction. After the two beams have been recombined, only those neutrons are chosen, which have a spin parallel to their direction of motion. All the others are just ignored. “This is called postselection”, says Hermann Geppert. “The beam contains neutrons of both spin directions, but we only analyse part of the neutrons.”

These neutrons, which are found to have a spin parallel to its direction of motion, must clearly have travelled along the upper path – only there, the neutrons have this spin state. This can be shown in the experiment. If the lower beam is sent through a filter which absorbs some of the neutrons, then the number of the neutrons with spin parallel to their trajectory stays the same. If the upper beam is sent through a filter, than the number of these neutrons is reduced.

Things get tricky, when the system is used to measure where the neutron spin is located: the spin can be slightly changed using a magnetic field. When the two beams are recombined appropriately, they can amplify or cancel each other. This is exactly what can be seen in the measurement, if the magnetic field is applied at the lower beam – but that is the path which the neutrons considered in the experiment are actually never supposed to take. A magnetic field applied to the upper beam, on the other hand, does not have any effect.

“By preparing the neurons in a special initial state and then postselecting another state, we can achieve a situation in which both the possible paths in the interferometer are important for the experiment, but in very different ways”, says Tobias Denkmayr. “Along one of the paths, the particles themselves couple to our measurement device, but only the other path is sensitive to magnetic spin coupling. The system behaves as if the particles were spatially separated from their properties.”

Here’s an illustration the researchers have provided,

Caption: The basic idea of the Quantum Cheshire Cat: In an interferometer, an object is separated from one if its properties -- like a cat, moving on a different path than its own grin. Credit: TU Vienna / Leon Filter

Caption: The basic idea of the Quantum Cheshire Cat: In an interferometer, an object is separated from one if its properties — like a cat, moving on a different path than its own grin.
Credit: TU Vienna / Leon Filter

Here’s a link to and a citation for the paper,

Observation of a quantum Cheshire Cat in a matter-wave interferometer experiment by Tobias Denkmayr, Hermann Geppert, Stephan Sponar, Hartmut Lemmel, Alexandre Matzkin, Jeff Tollaksen, & Yuji Hasegawa. Nature Communications 5 Article number: 4492 doi:10.1038/ncomms5492 Published 29 July 2014

This is an open access paper.

Perhaps in response to concerns about the importance of theoretical physics, Chapman University’s Jeff Tollaksen offers this about possible applications  (from the Chapman University news release),

Co-Director of the Institute for Quantum Studies, Prof. Jeff Tollaksen has said: “Theoretical physics has yielded the most significant benefits for our society at the lowest costs. Discoveries in fundamental physics often lead to new industries: from electricity to smartphones to satellites. Quantum physics resulted in technological advances that drive our economy, such as the entire computer revolution, electronics, and the nuclear power industry. In addition, it impacts many other disciplines such as genetics, medicine and mathematics. Experts therefore estimate that nearly half the wealth created in the 20th century arose from quantum physics. At the Institute, we’re committed to producing the next generation of breakthroughs which will lead to the technology of the 21st century. Similarly, I’m sure this breakthrough will lead to many new applications including revised intuitions which can then serve as a guide to finding novel quantum effects.” This “Quantum Cheshire Cat” could be used for practical applications. For example, it could be used to make high precision measurements less sensitive to external perturbations. The measurements which now have been published in Nature Communications are the first experimental proof of this phenomenon.

By contrast the Europeans offer this,

With their landmark observation suitably vindicated, questions turn to the potential impact of their fundamental discovery. One application might high precision measurements of quantum systems which are often affected by disturbance.  [from the Institut Laue-Langevin news release]

Or, there’s this,

This counter intuitive effect is very interesting for high precision measurements, which are very often based on the principle of quantum interference. “When the quantum system has a property you want to measure and another property which makes the system prone to perturbations, the two can be separated using a Quantum Cheshire Cat, and possibly the perturbation can be minimized”, says Stephan Sponar. [from the Vienna University of Technology news release]

The contrast is certainly interesting.

Metaphors in a brief overview of the nanomedicine scene circa August 2014

An Aug. 1, 2014 article by Guizhi Zhu (University of Florida), Lei Mei ((Hunan University; China), and Weihong Tan (University of Florida) for The Scientist provides an overview of the latest and greatest regarding nanomedicine while underscoring the persistence of certain medical metaphors. This overview features a prediction and a relatively benign (pun intended) metaphor,

Both the academic community and the pharmaceutical industry are making increasing investments of time and money in nanotherapeutics. Nearly 50 biomedical products incorporating nanoparticles are already on the market, and many more are moving through the pipeline, with dozens in Phase 2 or Phase 3 clinical trials. Drugmakers are well on their way to realizing the prediction of Christopher Guiffre, chief business officer at the Cambridge, Massachusetts–based nanotherapeutics company Cerulean Pharma, who last November forecast, “Five years from now every pharma will have a nano program.”

Technologies that enable improved cancer detection are constantly racing against the diseases they aim to diagnose, and when survival depends on early intervention, losing this race can be fatal. [emphasis mine] While detecting cancer biomarkers is the key to early diagnosis, the number of bona fide biomarkers that reliably reveal the presence of cancerous cells is low. To overcome this challenge, researchers are developing functional nanomaterials for more sensitive detection of intracellular metabolites, tumor cell–membrane proteins, and even cancer cells that are circulating in the bloodstream. (See “Fighting Cancer with Nanomedicine,” The Scientist, April 2014.)

So, the first metaphor ‘racing’ gives the reader a sense of urgency, the next ones, including “fighting cancer’, provoke a somewhat different state of mind,

Eye on the target

The prototype of targeted drug delivery can be traced back to the concept of a “magic bullet,” proposed by chemotherapy pioneer and 1908 Nobel laureate Paul Ehrlich. [emphasis mine] E[hrlich envisioned a drug that could selectively target a disease-causing organism or diseased cells, leaving healthy tissue unharmed. A century later, researchers are developing many types of nanoscale “magic bullets” that can specifically deliver drugs into target cells or tissues.

It would seem we might be in a state of war as you 'fight cancer' with your 'eyes on the target' as you 'shoot magic bullets' in time to celebrate the 100th anniversary of the start to World War I.

Kostas Kostarelos wrote a Nov. 29, 2013 posting for the Guardian Science Blogs where he (professor of nanomedicine at the University of Manchester and director of the university's Nanomedicine Lab) discussed war metaphors in medicine and possible unintended consequences (Note: A link has been removed). Here's his discussion about the metaphors,

Almost every night I have watched the news these past few months my senses have been assaulted by unpleasant, at times distressing, images of war: missiles, killings and chemical bombs in Syria, Kenya, the USA. I wake up the next morning, trying to forget what I watched the night before, and going to work with our researchers to develop the next potential high-tech cure for cancer, thinking: "does what we do matter at all … ?"

So I was intrigued by an article that will be published in one of the scientific journals in our field entitled: "Nanomedicine metaphors: from war to care". The next lab meeting we had was very awkward, because I was constantly thinking that indeed a lot of the words we were using to communicate our science were directly imported from the language of war. Targeting, stealth nanoparticle, smart bomb, elimination, triggered release, cell death. I struggled to find alternative language.


... Hollywood analogies and simplistic interpretations about "good" and "bad" may be inaccurate, but they do seem appropriate and convincing.

I must say, however, that even in pathology, modern medicine increasingly considers the disease to be part of our body, often leading to successful treatment not by "eradication" and "elimination" but by holistic management of a chronic condition. The case of HIV therapeutics is perhaps the brightest example of such revisionist thinking, which has transformed the disease from a "death sentence" in the early years after its discovery to a nonlethal chronic infection today.

Kostarelos then contrasts the less warlike 'modern medicine' metaphors with nanomedicine,

In nanomedicine, which is the application of nanotechnologies and nanomaterials to design medical treatments, the war imagery is even more prevalent. Two of the most clinically successful and intensively studied technologies that operate at the nanoscale are "stealth" and "targeted" medicines. "Stealth" refers to a hydrophilic (water-loving) shield built around a molecule or nanoparticle, made from polymers, that minimises its recognition by the body's defence mechanisms. "Targeting" refers to the specific binding of certain molecules (such as antibodies, peptides and others) to receptors (or other proteins) present only at the surface of diseased cells. The literature in nanomedicine is abundant with both "stealthing", "targeting" and combinations thereof.

Kostarelos then asks this question,

The question I keep asking myself since I read the article about war metaphors in nanomedicine has been whether we are using terminology in a simplistic, single-minded manner that could stifle creative and out-of-the-box thinking.

Intriguing unintended consequences, yes?

Getting back to The Scientist article, which I found quite informative and interesting, its 'war metaphors' seem to extend even to some of the artwork accompanying the article,

[downloaded from http://www.the-scientist.com/?articles.view/articleNo/40598/title/Nanomedicine/]

[downloaded from http://www.the-scientist.com/?articles.view/articleNo/40598/title/Nanomedicine/]

Is that a capsule or a bullet? Regardless, this * article provides a good overview of the research.

* The word ‘a’ was removed on Aug. 8, 2014.

Graphene oxide in liquid crystal droplets could be used in medical applications

Not everyone has been seduced by all the talk of graphene and electronics, it seems researchers at Monash University in Australia have researched graphene with an eye to its potential use in medical applications. From an Aug. 6, 2014 news item on ScienceDaily,

A chance discovery about the ‘wonder material’ graphene — already exciting scientists because of its potential uses in electronics, energy storage and energy generation — takes it a step closer to being used in medicine and human health.

Researchers from Monash University have discovered that graphene oxide sheets can change structure to become liquid crystal droplets spontaneously and without any specialist equipment.

With graphene droplets now easy to produce, researchers say this opens up possibilities for its use in drug delivery and disease detection.

The findings, published in the journal ChemComm, build on existing knowledge about graphene. One of the thinnest and strongest materials known to man, graphene is a 2D sheet of carbon just one atom thick. With a ‘honeycomb’ structure the ‘wonder material’ is 100 times stronger than steel, highly conductive and flexible.

An Aug. 6, 2014 Monash University media release (also on EurekAlert but dated Aug. 5, 2014), which originated the news item, describes the findings in more detail,

Dr Mainak Majumder from the Faculty of Engineering said because graphene droplets change their structure in response to the presence of an external magnetic field, it could be used for controlled drug release applications.

“Drug delivery systems tend to use magnetic particles which are very effective but they can’t always be used because these particles can be toxic in certain physiological conditions,” Dr Majumder said.

“In contrast, graphene doesn’t contain any magnetic properties. This combined with the fact that we have proved it can be changed into liquid crystal simply and cheaply, strengthens the prospect that it may one day be used for a new kind of drug delivery system.”

Usually atomisers and mechanical equipment are needed to change graphene into a spherical form. In this case all the team did was to put the graphene sheets in a solution to process it for industrial use. Under certain pH conditions they found that graphene behaves like a polymer – changing shape by itself.

First author of the paper, Ms Rachel Tkacz from the Faculty of Engineering, said the surprise discovery happened during routine tests.

“To be able to spontaneously change the structure of graphene from single sheets to a spherical assembly is hugely significant. No one thought that was possible. We’ve proved it is,” Ms Tkacz said.

“Now we know that graphene-based assemblies can spontaneously change shape under certain conditions, we can apply this knowledge to see if it changes when exposed to toxins, potentially paving the way for new methods of disease detection as well.”

Commonly used by jewelers, the team used an advanced version of a polarised light microscope based at the Marine Biological Laboratory, USA, to detect minute changes to grapheme.

Dr Majumder said collaborating with researchers internationally and accessing some of the most sophisticated equipment in the world, was instrumental to the breakthrough discovery.

“We used microscopes similar to the ones jewelers use to see the clarity of precious gems. The only difference is the ones we used are much more precise due to a sophisticated system of hardware and software. This provides us with crucial information about the organisation of graphene sheets, enabling us to recognise these unique structures,” Dr Majumder said.

Dr Majumder and his team are working with graphite industry partner, Strategic Energy Resources Ltd and an expert in polarized light imaging, Dr. Rudolf Oldenbourg from the Marine Biological Laboratory, USA, to explore how this work can be translated and commercialised.

Here’s a link to and a citation for the paper,

pH dependent isotropic to nematic phase transitions in graphene oxide dispersions reveal droplet liquid crystalline phases by Rachel Tkacz, Rudolf Oldenbourg, Shalin B. Mehta, Morteza Miansari, Amitabh Verma, and Mainak Majumder. Chem. Commun., 2014,50, 6668-6671 DOI: 10.1039/C4CC00970C First published online 06 May 2014

This paper is behind a paywall.

Things falling apart: both a Nigerian novel and research at the Massachusetts Intitute of Technology

First the Nigerian novel ‘Things Fall Apart‘ (from its Wikipedia entry; Note: Links have been removed),

Things Fall Apart is an English-language novel by Nigerian author Chinua Achebe published in 1958 by William Heinemann Ltd in the UK; in 1962, it was also the first work published in Heinemann’s African Writers Series. Things Fall Apart is seen as the archetypal modern African novel in English, one of the first to receive global critical acclaim. It is a staple book in schools throughout Africa and is widely read and studied in English-speaking countries around the world. The title of the novel comes from William Butler Yeats’ poem “The Second Coming”.[1]

For those unfamiliar with the Yeats poem, this is the relevant passage (from Wikipedia entry for The Second Coming),

Turning and turning in the widening gyre
The falcon cannot hear the falconer;
Things fall apart; the centre cannot hold;
Mere anarchy is loosed upon the world,
The blood-dimmed tide is loosed, and everywhere
The ceremony of innocence is drowned;
The best lack all conviction, while the worst
Are full of passionate intensity.

The other ‘Things fall apart’ item, although it’s an investigation into ‘how things fall apart’, is mentioned in an Aug. 4, 2014 news item on Nanowerk,

Materials that are firmly bonded together with epoxy and other tough adhesives are ubiquitous in modern life — from crowns on teeth to modern composites used in construction. Yet it has proved remarkably difficult to study how these bonds fracture and fail, and how to make them more resistant to such failures.

Now researchers at MIT [Massachusetts Institute of Technology] have found a way to study these bonding failures directly, revealing the crucial role of moisture in setting the stage for failure. Their findings are published in the journal Proceedings of the National Academy of Science in a paper by MIT professors of civil and environmental engineering Oral Buyukozturk and Markus Buehler; research associate Kurt Broderick of MIT’s Microsystems Technology Laboratories; and doctoral student Denvid Lau, who has since joined the faculty at the City University of Hong Kong.

An Aug. 4, 2014 MIT news release written by David Chandler (also on EurekAlert), which originated the news item, provides an unexpectedly fascinating discussion of bonding, interfaces, and infrastructure,

“The bonding problem is a general problem that is encountered in many disciplines, especially in medicine and dentistry,” says Buyukozturk, whose research has focused on infrastructure, where such problems are also of great importance. “The interface between a base material and epoxy, for example, really controls the properties. If the interface is weak, you lose the entire system.”

“The composite may be made of a strong and durable material bonded to another strong and durable material,” Buyukozturk adds, “but where you bond them doesn’t necessarily have to be strong and durable.”

Besides dental implants and joint replacements, such bonding is also critical in construction materials such as fiber-reinforced polymers and reinforced concrete. But while such materials are widespread, understanding how they fail is not simple.

There are standard methods for testing the strength of materials and how they may fail structurally, but bonded surfaces are more difficult to model. “When we are concerned with deterioration of this interface when it is degraded by moisture, classical methods can’t handle that,” Buyukozturk says. “The way to approach it is to look at the molecular level.”

When such systems are exposed to moisture, “it initiates new molecules at the interface,” Buyukozturk says, “and that interferes with the bonding mechanism. How do you assess how weak the interface becomes when it is affected? We came up with an innovative method to assess the interface weakening as a result of exposure to environmental effects.”

The team used a combination of molecular simulations and laboratory tests in its assessment. The modeling was based on fundamental principles of molecular interactions, not on empirical data, Buyukozturk says.

In the laboratory tests, Buyukozturk and his colleagues controlled the residual stresses in a metal layer that was bonded and then forcibly removed. “We validated the method, and showed that moisture has a degrading effect,” he says.

The findings could lead to exploration of new ways to prevent moisture from reaching into the bonded layer, perhaps using better sealants. “Moisture is the No. 1 enemy,” Buyukozturk says.

“I think this is going to be an important step toward assessment of the bonding, and enable us to design more durable composites,” he adds. “It gives a quantitative knowledge of the interface” — for example, predicting that under specific conditions, a given bonded material will lose 30 percent of its strength.

Interface problems are universal, Buyukozturk says, occurring in many areas besides biomedicine and construction. “They occur in mechanical devices, in aircraft, electrical equipment, in the packaging of electronic components,” he says. “We feel this will have very broad applications.”

Bonded composite materials are beginning to be widely used in airplane manufacturing; often these composites are then bonded to traditional materials, like aluminum. “We have not had enough experience to prove the durability of these composite systems is going to be there after 20 years,” Buyukozturk says.

Here’s a link to and a citation for the research paper,

A robust nanoscale experimental quantification of fracture energy in a bilayer material system by Denvid Lau, Kurt Broderick, Markus J. Buehler, and Oral Büyüköztürk. PNAS, doi: 10.1073/pnas.1402893111 published August 5, 2014

This paper is behind a paywall.

Hummingbirds and ‘nano’ spy cameras

Hummingbird-inspired spy cameras have come a long way since the research featured in this Aug. 12, 2011 posting which includes a video of a robot camera designed to look like a hummingbird and mimic some of its extraordinary flying abilities. These days (2014) the emphasis appears to be on mimicking the abilities to a finer degree if Margaret Munro’s July 29, 2014 article for Canada.com is to be believed,

Tiny, high-end military drones are catching up with one of nature’s great engineering masterpieces.

A side-by-side comparison has found a “remarkably similar” aerodynamic performance between hummingbirds and the Black Hornet, the most sophisticated nano spycam yet.

“(The) Average Joe hummingbird” is about on par with the tiny helicopter that is so small it can fit in a pocket, says engineering professor David Lentink, at Stanford University. He led a team from Canada [University of British Columbia], the U.S. and the Netherlands [Wageningen University and Eindhoven University of Technology] that compared the birds and the machine for a study released Tuesday [July 29, 2014].

For a visual comparison with the latest nano spycam (Black Hornet), here’s the ‘hummingbird’ featured in the 2011 posting,

The  Nano Hummingbird, a drone from AeroVironment designed for the US Pentagon, would fit into any or all of those categories.

And, here’s this 2013 image of a Black Hornet Nano Helicopter inspired by hummingbirds,

Black Hornet Nano Helicopter UAVView licenseview terms Richard Watt - Photo http://www.defenceimagery.mod.uk/fotoweb/fwbin/download.dll/45153802.jpgCourtesy: Wikipedia

Black Hornet Nano Helicopter UAVView licenseview terms
Richard Watt – Photo http://www.defenceimagery.mod.uk/fotoweb/fwbin/download.dll/45153802.jpg Courtesy: Wikipedia

A July 30, 2014 Stanford University news release by Bjorn Carey provides more details about this latest research into hummingbirds and their flying ways,

More than 42 million years of natural selection have turned hummingbirds into some of the world’s most energetically efficient flyers, particularly when it comes to hovering in place.

Humans, however, are gaining ground quickly. A new study led by David Lentink, an assistant professor of mechanical engineering at Stanford, reveals that the spinning blades of micro-helicopters are about as efficient at hovering as the average hummingbird.

The experiment involved spinning hummingbird wings – sourced from a pre-existing museum collection – of 12 different species on an apparatus designed to test the aerodynamics of helicopter blades. The researchers used cameras to visualize airflow around the wings, and sensitive load cells to measure the drag and the lift force they exerted, at different speeds and angles.

Lentink and his colleagues then replicated the experiment using the blades from a ProxDynamics Black Hornet autonomous microhelicopter. The Black Hornet is the most sophisticated microcopter available – the United Kingdom’s army uses it in Afghanistan – and is itself about the size of a hummingbird.

Even spinning like a helicopter, rather than flapping, the hummingbird wings excelled: If hummingbirds were able to spin their wings to hover, it would cost them roughly half as much energy as flapping. The microcopter’s wings kept pace with the middle-of-the-pack hummingbird wings, but the topflight wings – those of Anna’s hummingbird, a species common throughout the West Coast – were still about 27 percent more efficient than engineered blades.

Hummingbirds acing the test didn’t particularly surprise Lentink – previous studies had indicated hummingbirds were incredibly efficient – but he was impressed with the helicopter.

“The technology is at the level of an average Joe hummingbird,” Lentink said. “A helicopter is really the most efficient hovering device that we can build. The best hummingbirds are still better, but I think it’s amazing that we’re getting closer. It’s not easy to match their performance, but if we build better wings with better shapes, we might approximate hummingbirds.”

Based on the measurements of Anna’s hummingbirds, Lentink said there is potential to improve microcopter rotor power by up to 27 percent.

The high-fidelity experiment also provided an opportunity to refine previous rough estimates of muscle power. Lentink’s team learned that hummingbirds’ muscles produce a surprising 130 watts of energy per kilogram; the average for other birds, and across most vertebrates, is roughly 100 watts/kg.

Although the current study revealed several details of how a hummingbird hovers in one place, the birds still hold many secrets. For instance, Lentink said, we don’t know how hummingbirds maintain their flight in a strong gust, how they navigate through branches and other clutter, or how they change direction so quickly during aerial “dogfights.”

He also thinks great strides could be made by studying wing aspect ratios, the ratio of wing length to wing width. The aspect ratios of all the hummingbirds’ wings remarkably converged around 3.9. The aspect ratios of most wings used in aviation measure much higher; the Black Hornet’s aspect ratio was 4.7.

“I want to understand if aspect ratio is special, and whether the amount of variation has an effect on performance,” Lentink said. Understanding and replicating these abilities and characteristics could be a boon for robotics and will be the focus of future experiments.

“Those are the things we don’t know right now, and they could be incredibly useful. But I don’t mind it, actually,” Lentink said. “I think it’s nice that there are still a few things about hummingbirds that we don’t know.”

Agreed, it’s nice to know there are still a few mysteries left. You can watch the ‘mysterious’ hummingbird in this video courtesy of the Rivers Ingersoll Lentink Lab at Stanford University,

High speed video of Anna’s hummingbird at Stanford Arizona Cactus Garden.

Here’s a link to and a citation for the paper, H/T to Nancy Owano’s article on phys.org for alerting me to this story.

Hummingbird wing efficacy depends on aspect ratio and compares with helicopter rotors by Jan W. Kruyt, Elsa M. Quicazán-Rubio, GertJan F. van Heijst, Douglas L. Altshuler, and David Lentink.  J. R. Soc. Interface 6 October 2014 vol. 11 no. 99 20140585 doi: 10.1098/​rsif.2014.0585 Published [online] 30 July 2014

This is an open access paper.

Despite Munro’s reference to the Black Hornet as a ‘nano’ spycam, the ‘microhelicopter’ description in the news release places the device at the microscale (/1,000,000,000). Still, I don’t understand what makes it microscale since it’s visible to the naked eye. In any case, it is small.