Category Archives: innovation

Artificial intelligence (AI) brings together International Telecommunications Union (ITU) and World Health Organization (WHO) and AI outperforms animal testing

Following on my May 11, 2018 posting about the International Telecommunications Union (ITU) and the 2018 AI for Good Global Summit in mid- May, there’s an announcement. My other bit of AI news concerns animal testing.

Leveraging the power of AI for health

A July 24, 2018 ITU press release (a shorter version was received via email) announces a joint initiative focused on improving health,

Two United Nations specialized agencies are joining forces to expand the use of artificial intelligence (AI) in the health sector to a global scale, and to leverage the power of AI to advance health for all worldwide. The International Telecommunication Union (ITU) and the World Health Organization (WHO) will work together through the newly established ITU Focus Group on AI for Health to develop an international “AI for health” standards framework and to identify use cases of AI in the health sector that can be scaled-up for global impact. The group is open to all interested parties.

“AI could help patients to assess their symptoms, enable medical professionals in underserved areas to focus on critical cases, and save great numbers of lives in emergencies by delivering medical diagnoses to hospitals before patients arrive to be treated,” said ITU Secretary-General Houlin Zhao. “ITU and WHO plan to ensure that such capabilities are available worldwide for the benefit of everyone, everywhere.”

The demand for such a platform was first identified by participants of the second AI for Good Global Summit held in Geneva, 15-17 May 2018. During the summit, AI and the health sector were recognized as a very promising combination, and it was announced that AI-powered technologies such as skin disease recognition and diagnostic applications based on symptom questions could be deployed on six billion smartphones by 2021.

The ITU Focus Group on AI for Health is coordinated through ITU’s Telecommunications Standardization Sector – which works with ITU’s 193 Member States and more than 800 industry and academic members to establish global standards for emerging ICT innovations. It will lead an intensive two-year analysis of international standardization opportunities towards delivery of a benchmarking framework of international standards and recommendations by ITU and WHO for the use of AI in the health sector.

“I believe the subject of AI for health is both important and useful for advancing health for all,” said WHO Director-General Tedros Adhanom Ghebreyesus.

The ITU Focus Group on AI for Health will also engage researchers, engineers, practitioners, entrepreneurs and policy makers to develop guidance documents for national administrations, to steer the creation of policies that ensure the safe, appropriate use of AI in the health sector.

“1.3 billion people have a mobile phone and we can use this technology to provide AI-powered health data analytics to people with limited or no access to medical care. AI can enhance health by improving medical diagnostics and associated health intervention decisions on a global scale,” said Thomas Wiegand, ITU Focus Group on AI for Health Chairman, and Executive Director of the Fraunhofer Heinrich Hertz Institute, as well as professor at TU Berlin.

He added, “The health sector is in many countries among the largest economic sectors or one of the fastest-growing, signalling a particularly timely need for international standardization of the convergence of AI and health.”

Data analytics are certain to form a large part of the ITU focus group’s work. AI systems are proving increasingly adept at interpreting laboratory results and medical imagery and extracting diagnostically relevant information from text or complex sensor streams.

As part of this, the ITU Focus Group for AI for Health will also produce an assessment framework to standardize the evaluation and validation of AI algorithms — including the identification of structured and normalized data to train AI algorithms. It will develop open benchmarks with the aim of these becoming international standards.

The ITU Focus Group for AI for Health will report to the ITU standardization expert group for multimedia, Study Group 16.

I got curious about Study Group 16 (from the Study Group 16 at a glance webpage),

Study Group 16 leads ITU’s standardization work on multimedia coding, systems and applications, including the coordination of related studies across the various ITU-T SGs. It is also the lead study group on ubiquitous and Internet of Things (IoT) applications; telecommunication/ICT accessibility for persons with disabilities; intelligent transport system (ITS) communications; e-health; and Internet Protocol television (IPTV).

Multimedia is at the core of the most recent advances in information and communication technologies (ICTs) – especially when we consider that most innovation today is agnostic of the transport and network layers, focusing rather on the higher OSI model layers.

SG16 is active in all aspects of multimedia standardization, including terminals, architecture, protocols, security, mobility, interworking and quality of service (QoS). It focuses its studies on telepresence and conferencing systems; IPTV; digital signage; speech, audio and visual coding; network signal processing; PSTN modems and interfaces; facsimile terminals; and ICT accessibility.

…

I wonder which group deals with artificial intelligence and, possibly, robots.

Chemical testing without animals

Thomas Hartung, professor of environmental health and engineering at Johns Hopkins University (US), describes in his July 25, 2018 essay (written for The Conversation) on phys.org the situation where chemical testing is concerned,

Most consumers would be dismayed with how little we know about the majority of chemicals. Only 3 percent of industrial chemicals – mostly drugs and pesticides – are comprehensively tested. Most of the 80,000 to 140,000 chemicals in consumer products have not been tested at all or just examined superficially to see what harm they may do locally, at the site of contact and at extremely high doses.

I am a physician and former head of the European Center for the Validation of Alternative Methods of the European Commission (2002-2008), and I am dedicated to finding faster, cheaper and more accurate methods of testing the safety of chemicals. To that end, I now lead a new program at Johns Hopkins University to revamp the safety sciences.

As part of this effort, we have now developed a computer method of testing chemicals that could save more than a US$1 billion annually and more than 2 million animals. Especially in times where the government is rolling back regulations on the chemical industry, new methods to identify dangerous substances are critical for human and environmental health.

Having written on the topic of alternatives to animal testing on a number of occasions (my December 26, 2014 posting provides an overview of sorts), I was particularly interested to see this in Hartung’s July 25, 2018 essay on The Conversation (Note: Links have been removed),

Following the vision of Toxicology for the 21st Century, a movement led by U.S. agencies to revamp safety testing, important work was carried out by my Ph.D. student Tom Luechtefeld at the Johns Hopkins Center for Alternatives to Animal Testing. Teaming up with Underwriters Laboratories, we have now leveraged an expanded database and machine learning to predict toxic properties. As we report in the journal Toxicological Sciences, we developed a novel algorithm and database for analyzing chemicals and determining their toxicity – what we call read-across structure activity relationship, RASAR.

This graphic reveals a small part of the chemical universe. Each dot represents a different chemical. Chemicals that are close together have similar structures and often properties. Thomas Hartung, CC BY-SA

To do this, we first created an enormous database with 10 million chemical structures by adding more public databases filled with chemical data, which, if you crunch the numbers, represent 50 trillion pairs of chemicals. A supercomputer then created a map of the chemical universe, in which chemicals are positioned close together if they share many structures in common and far where they don’t. Most of the time, any molecule close to a toxic molecule is also dangerous. Even more likely if many toxic substances are close, harmless substances are far. Any substance can now be analyzed by placing it into this map.

If this sounds simple, it’s not. It requires half a billion mathematical calculations per chemical to see where it fits. The chemical neighborhood focuses on 74 characteristics which are used to predict the properties of a substance. Using the properties of the neighboring chemicals, we can predict whether an untested chemical is hazardous. For example, for predicting whether a chemical will cause eye irritation, our computer program not only uses information from similar chemicals, which were tested on rabbit eyes, but also information for skin irritation. This is because what typically irritates the skin also harms the eye.

How well does the computer identify toxic chemicals?

This method will be used for new untested substances. However, if you do this for chemicals for which you actually have data, and compare prediction with reality, you can test how well this prediction works. We did this for 48,000 chemicals that were well characterized for at least one aspect of toxicity, and we found the toxic substances in 89 percent of cases.

This is clearly more accurate that the corresponding animal tests which only yield the correct answer 70 percent of the time. The RASAR shall now be formally validated by an interagency committee of 16 U.S. agencies, including the EPA [Environmental Protection Agency] and FDA [Food and Drug Administration], that will challenge our computer program with chemicals for which the outcome is unknown. This is a prerequisite for acceptance and use in many countries and industries.

The potential is enormous: The RASAR approach is in essence based on chemical data that was registered for the 2010 and 2013 REACH [Registration, Evaluation, Authorizations and Restriction of Chemicals] deadlines [in Europe]. If our estimates are correct and chemical producers would have not registered chemicals after 2013, and instead used our RASAR program, we would have saved 2.8 million animals and $490 million in testing costs – and received more reliable data. We have to admit that this is a very theoretical calculation, but it shows how valuable this approach could be for other regulatory programs and safety assessments.

In the future, a chemist could check RASAR before even synthesizing their next chemical to check whether the new structure will have problems. Or a product developer can pick alternatives to toxic substances to use in their products. This is a powerful technology, which is only starting to show all its potential.

It’s been my experience that these claims having led a movement (Toxicology for the 21st Century) are often contested with many others competing for the title of ‘leader’ or ‘first’. That said, this RASAR approach seems very exciting, especially in light of the skepticism about limiting and/or making animal testing unnecessary noted in my December 26, 2014 posting.it was from someone I thought knew better.

Here’s a link to and a citation for the paper mentioned in Hartung’s essay,

Machine learning of toxicological big data enables read-across structure activity relationships (RASAR) outperforming animal test reproducibility by Thomas Luechtefeld, Dan Marsh, Craig Rowlands, Thomas Hartung. Toxicological Sciences, kfy152, https://doi.org/10.1093/toxsci/kfy152 Published: 11 July 2018

This paper is open access.

I found it at the movies: a commentary on/review of “Films from the Future”

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Kudos to anyone who recognized the reference to Pauline Kael (she changed film criticism forever) and her book “I Lost it at the Movies.” Of course, her book title was a bit of sexual innuendo, quite risqué for an important film critic in 1965 but appropriate for a period (the 1960s) associated with a sexual revolution. (There’s more about the 1960’s sexual revolution in the US along with mention of a prior sexual revolution in the 1920s in this Wikipedia entry.)

The title for this commentary is based on an anecdote from Dr. Andrew Maynard’s (director of the Arizona State University [ASU] Risk Innovation Lab) popular science and technology book, “Films from the Future: The Technology and Morality of Sci-Fi Movies.”

The ‘title-inspiring’ anecdote concerns Maynard’s first viewing of ‘2001: A Space Odyssey, when as a rather “bratty” 16-year-old who preferred to read science fiction, he discovered new ways of seeing and imaging the world. Maynard isn’t explicit about when he became a ‘techno nerd’ or how movies gave him an experience books couldn’t but presumably at 16 he was already gearing up for a career in the sciences. That ‘movie’ revelation received in front of a black and white television on January 1,1982 eventually led him to write, “Films from the Future.” (He has a PhD in physics which he is now applying to the field of risk innovation. For a more detailed description of Dr. Maynard and his work, there’s his ASU profile webpage and, of course, the introduction to his book.)

The book is quite timely. I don’t know how many people have noticed but science and scientific innovation is being covered more frequently in the media than it has been in many years. Science fairs and festivals are being founded on what seems to be a daily basis and you can now find science in art galleries. (Not to mention the movies and television where science topics are covered in comic book adaptations, in comedy, and in standard science fiction style.) Much of this activity is centered on what’s called ’emerging technologies’. These technologies are why people argue for what’s known as ‘blue sky’ or ‘basic’ or ‘fundamental’ science for without that science there would be no emerging technology.

Films from the Future

Isn’t reading the Table of Contents (ToC) the best way to approach a book? (From Films from the Future; Note: The formatting has been altered),

Table of Contents
Chapter One
In the Beginning 14
Beginnings 14
Welcome to the Future 16
The Power of Convergence 18
Socially Responsible Innovation 21
A Common Point of Focus 25
Spoiler Alert 26
Chapter Two
Jurassic Park: The Rise of Resurrection Biology 27
When Dinosaurs Ruled the World 27
De-Extinction 31
Could We, Should We? 36
The Butterfly Effect 39
Visions of Power 43
Chapter Three
Never Let Me Go: A Cautionary Tale of Human Cloning 46
Sins of Futures Past 46
Cloning 51
Genuinely Human? 56
Too Valuable to Fail? 62
Chapter Four
Minority Report: Predicting Criminal Intent 64
Criminal Intent 64
The “Science” of Predicting Bad Behavior 69
Criminal Brain Scans 74
Machine Learning-Based Precognition 77
Big Brother, Meet Big Data 79
Chapter Five
Limitless: Pharmaceutically-enhanced Intelligence 86
A Pill for Everything 86
The Seduction of Self-Enhancement 89
Nootropics 91
If You Could, Would You? 97
Privileged Technology 101
Our Obsession with Intelligence 105
Chapter Six
Elysium: Social Inequity in an Age of Technological
Extremes 110
The Poor Shall Inherit the Earth 110
Bioprinting Our Future Bodies 115
The Disposable Workforce 119
Living in an Automated Future 124
Chapter Seven
Ghost in the Shell: Being Human in an
Augmented Future 129
Through a Glass Darkly 129
Body Hacking 135
More than “Human”? 137
Plugged In, Hacked Out 142
Your Corporate Body 147
Chapter Eight
Ex Machina: AI and the Art of Manipulation 154
Plato’s Cave 154
The Lure of Permissionless Innovation 160
Technologies of Hubris 164
Superintelligence 169
Defining Artificial Intelligence 172
Artificial Manipulation 175
Chapter Nine
Transcendence: Welcome to the Singularity 180
Visions of the Future 180
Technological Convergence 184
Enter the Neo-Luddites 190
Techno-Terrorism 194
Exponential Extrapolation 200
Make-Believe in the Age of the Singularity 203
Chapter Ten
The Man in the White Suit: Living in a Material World 208
There’s Plenty of Room at the Bottom 208
Mastering the Material World 213
Myopically Benevolent Science 220
Never Underestimate the Status Quo 224
It’s Good to Talk 227
Chapter Eleven
Inferno: Immoral Logic in an Age of
Genetic Manipulation 231
Decoding Make-Believe 231
Weaponizing the Genome 234
Immoral Logic? 238
The Honest Broker 242
Dictating the Future 248
Chapter Twelve
The Day After Tomorrow: Riding the Wave of
Climate Change 251
Our Changing Climate 251
Fragile States 255
A Planetary “Microbiome” 258
The Rise of the Anthropocene 260
Building Resiliency 262
Geoengineering the Future 266
Chapter Thirteen
Contact: Living by More than Science Alone 272
An Awful Waste of Space 272
More than Science Alone 277
Occam’s Razor 280
What If We’re Not Alone? 283
Chapter Fourteen
Looking to the Future 288
Acknowledgments 293

The ToC gives the reader a pretty clue as to where the author is going with their book and Maynard explains how he chose his movies in his introductory chapter (from Films from the Future),

“There are some quite wonderful science fiction movies that didn’t make the cut because they didn’t fit the overarching narrative (Blade Runner and its sequel Blade Runner 2049, for instance, and the first of the Matrix trilogy). There are also movies that bombed with the critics, but were included because they ably fill a gap in the bigger story around emerging and converging technologies. Ultimately, the movies that made the cut were chosen because, together, they create an overarching narrative around emerging trends in biotechnologies, cybertechnologies, and materials-based technologies, and they illuminate a broader landscape around our evolving relationship with science and technology. And, to be honest, they are all movies that I get a kick out of watching.” (p. 17)

Jurassic Park (Chapter Two)

Dinosaurs do not interest me—they never have. Despite my profound indifference I did see the movie, Jurassic Park, when it was first released (someone talked me into going). And, I am still profoundly indifferent. Thankfully, Dr. Maynard finds meaning and a connection to current trends in biotechnology,

Jurassic Park is unabashedly a movie about dinosaurs. But it’s also a movie about greed, ambition, genetic engineering, and human folly—all rich pickings for thinking about the future, and what could possibly go wrong. (p. 28)

…

What really stands out with Jurassic Park, over twenty-five years later, is how it reveals a very human side of science and technology. This comes out in questions around when we should tinker with technology and when we should leave well enough alone. But there is also a narrative here that appears time and time again with the movies in this book, and that is how we get our heads around the sometimes oversized roles mega-entrepreneurs play in dictating how new tech is used, and possibly abused. These are all issues that are just as relevant now as they were in 1993, and are front and center of ensuring that the technologyenabled future we’re building is one where we want to live, and not one where we’re constantly fighting for our lives. (pp. 30-1)

He also describes a connection to current trends in biotechnology,

De-Extinction

In a far corner of Siberia, two Russians—Sergey Zimov and his son Nikita—are attempting to recreate the Ice Age. More precisely, their vision is to reconstruct the landscape and ecosystem of northern Siberia in the Pleistocene, a period in Earth’s history that stretches from around two and a half million years ago to eleven thousand years ago. This was a time when the environment was much colder than now, with huge glaciers and ice sheets flowing over much of the Earth’s northern hemisphere. It was also a time when humans
coexisted with animals that are long extinct, including saber-tooth cats, giant ground sloths, and woolly mammoths.

The Zimovs’ ambitions are an extreme example of “Pleistocene rewilding,” a movement to reintroduce relatively recently extinct large animals, or their close modern-day equivalents, to regions where they were once common. In the case of the Zimovs, the
father-and-son team believe that, by reconstructing the Pleistocene ecosystem in the Siberian steppes and elsewhere, they can slow down the impacts of climate change on these regions. These areas are dominated by permafrost, ground that never thaws through
the year. Permafrost ecosystems have developed and survived over millennia, but a warming global climate (a theme we’ll come back to in chapter twelve and the movie The Day After Tomorrow) threatens to catastrophically disrupt them, and as this happens, the impacts
on biodiversity could be devastating. But what gets climate scientists even more worried is potentially massive releases of trapped methane as the permafrost disappears.

Methane is a powerful greenhouse gas—some eighty times more effective at exacerbating global warming than carbon dioxide— and large-scale releases from warming permafrost could trigger catastrophic changes in climate. As a result, finding ways to keep it in the ground is important. And here the Zimovs came up with a rather unusual idea: maintaining the stability of the environment by reintroducing long-extinct species that could help prevent its destruction, even in a warmer world. It’s a wild idea, but one that has some merit.8 As a proof of concept, though, the Zimovs needed somewhere to start. And so they set out to create a park for deextinct Siberian animals: Pleistocene Park.9

Pleistocene Park is by no stretch of the imagination a modern-day Jurassic Park. The dinosaurs in Hammond’s park date back to the Mesozoic period, from around 250 million years ago to sixty-five million years ago. By comparison, the Pleistocene is relatively modern history, ending a mere eleven and a half thousand years ago. And the vision behind Pleistocene Park is not thrills, spills, and profit, but the serious use of science and technology to stabilize an increasingly unstable environment. Yet there is one thread that ties them together, and that’s using genetic engineering to reintroduce extinct species. In this case, the species in question is warm-blooded and furry: the woolly mammoth.

The idea of de-extinction, or bringing back species from extinction (it’s even called “resurrection biology” in some circles), has been around for a while. It’s a controversial idea, and it raises a lot of tough ethical questions. But proponents of de-extinction argue
that we’re losing species and ecosystems at such a rate that we can’t afford not to explore technological interventions to help stem the flow.

Early approaches to bringing species back from the dead have involved selective breeding. The idea was simple—if you have modern ancestors of a recently extinct species, selectively breeding specimens that have a higher genetic similarity to their forebears can potentially help reconstruct their genome in living animals. This approach is being used in attempts to bring back the aurochs, an ancestor of modern cattle.10 But it’s slow, and it depends on
the fragmented genome of the extinct species still surviving in its modern-day equivalents.

An alternative to selective breeding is cloning. This involves finding a viable cell, or cell nucleus, in an extinct but well-preserved animal and growing a new living clone from it. It’s definitely a more appealing route for impatient resurrection biologists, but it does mean getting your hands on intact cells from long-dead animals and devising ways to “resurrect” these, which is no mean feat. Cloning has potential when it comes to recently extinct species whose cells have been well preserved—for instance, where the whole animal has become frozen in ice. But it’s still a slow and extremely limited option.

Which is where advances in genetic engineering come in.

The technological premise of Jurassic Park is that scientists can reconstruct the genome of long-dead animals from preserved DNA fragments. It’s a compelling idea, if you think of DNA as a massively long and complex instruction set that tells a group of biological molecules how to build an animal. In principle, if we could reconstruct the genome of an extinct species, we would have the basic instruction set—the biological software—to reconstruct
individual members of it.

The bad news is that DNA-reconstruction-based de-extinction is far more complex than this. First you need intact fragments of DNA, which is not easy, as DNA degrades easily (and is pretty much impossible to obtain, as far as we know, for dinosaurs). Then you
need to be able to stitch all of your fragments together, which is akin to completing a billion-piece jigsaw puzzle without knowing what the final picture looks like. This is a Herculean task, although with breakthroughs in data manipulation and machine learning,
scientists are getting better at it. But even when you have your reconstructed genome, you need the biological “wetware”—all the stuff that’s needed to create, incubate, and nurture a new living thing, like eggs, nutrients, a safe space to grow and mature, and so on. Within all this complexity, it turns out that getting your DNA sequence right is just the beginning of translating that genetic code into a living, breathing entity. But in some cases, it might be possible.

In 2013, Sergey Zimov was introduced to the geneticist George Church at a conference on de-extinction. Church is an accomplished scientist in the field of DNA analysis and reconstruction, and a thought leader in the field of synthetic biology (which we’ll come
back to in chapter nine). It was a match made in resurrection biology heaven. Zimov wanted to populate his Pleistocene Park with mammoths, and Church thought he could see a way of
achieving this.

What resulted was an ambitious project to de-extinct the woolly mammoth. Church and others who are working on this have faced plenty of hurdles. But the technology has been advancing so fast that, as of 2017, scientists were predicting they would be able to reproduce the woolly mammoth within the next two years.

One of those hurdles was the lack of solid DNA sequences to work from. Frustratingly, although there are many instances of well preserved woolly mammoths, their DNA rarely survives being frozen for tens of thousands of years. To overcome this, Church and others
have taken a different tack: Take a modern, living relative of the mammoth, and engineer into it traits that would allow it to live on the Siberian tundra, just like its woolly ancestors.

Church’s team’s starting point has been the Asian elephant. This is their source of base DNA for their “woolly mammoth 2.0”—their starting source code, if you like. So far, they’ve identified fifty plus gene sequences they think they can play with to give their modern-day woolly mammoth the traits it would need to thrive in Pleistocene Park, including a coat of hair, smaller ears, and a constitution adapted to cold.

The next hurdle they face is how to translate the code embedded in their new woolly mammoth genome into a living, breathing animal. The most obvious route would be to impregnate a female Asian elephant with a fertilized egg containing the new code. But Asian elephants are endangered, and no one’s likely to allow such cutting edge experimentation on the precious few that are still around, so scientists are working on an artificial womb for their reinvented woolly mammoth. They’re making progress with mice and hope to crack the motherless mammoth challenge relatively soon.

It’s perhaps a stretch to call this creative approach to recreating a species (or “reanimation” as Church refers to it) “de-extinction,” as what is being formed is a new species. … (pp. 31-4)

This selection illustrates what Maynard does so very well throughout the book where he uses each film as a launching pad for a clear, readable description of relevant bits of science so you understand why the premise was likely, unlikely, or pure fantasy while linking it to contemporary practices, efforts, and issues. In the context of Jurassic Park, Maynard goes on to raise some fascinating questions such as: Should we revive animals rendered extinct (due to obsolescence or inability to adapt to new conditions) when we could develop new animals?

General thoughts

‘Films for the Future’ offers readable (to non-scientific types) science, lively writing, and the occasional ‘memorish’ anecdote. As well, Dr. Maynard raises the curtain on aspects of the scientific enterprise that most of us do not get to see. For example, the meeting between Sergey Zimov and George Church and how it led to new ‘de-extinction’ work’. He also describes the problems that the scientists encountered and are encountering. This is in direct contrast to how scientific work is usually presented in the news media as one glorious breakthrough after the next.

Maynard does discuss the issues of social inequality and power and ownership. For example, who owns your transplant or data? Puzzlingly, he doesn’t touch on the current environment where scientists in the US and elsewhere are encouraged/pressured to start up companies commercializing their work.

Nor is there any mention of how universities are participating in this grand business experiment often called ‘innovation’. (My March 15, 2017 posting describes an outcome for the CRISPR [gene editing system] patent fight taking place between Harvard University’s & MIT’s [Massachusetts Institute of Technology] Broad Institute vs the University of California at Berkeley and my Sept. 11, 2018 posting about an art/science exhibit in Vancouver [Canada] provides an update for round 2 of the Broad Institute vs. UC Berkeley patent fight [scroll down about 65% of the way.) *To read about how my ‘cultural blindness’ shows up here scroll down to the single asterisk at the end.*

There’s a foray through machine-learning and big data as applied to predictive policing in Maynard’s ‘Minority Report’ chapter (my November 23, 2017 posting describes Vancouver’s predictive policing initiative [no psychics involved], the first such in Canada). There’s no mention of surveillance technology, which if I recall properly was part of the future environment, both by the state and by corporations. (Mia Armstrong’s November 15, 2018 article for Slate on Chinese surveillance being exported to Venezuela provides interesting insight.)

The gaps are interesting and various. This of course points to a problem all science writers have when attempting an overview of science. (Carl Zimmer’s latest, ‘She Has Her Mother’s Laugh: The Powers, Perversions, and Potential of Heredity’] a doorstopping 574 pages, also has some gaps despite his focus on heredity,)

Maynard has worked hard to give an comprehensive overview in a remarkably compact 279 pages while developing his theme about science and the human element. In other words, science is not monolithic; it’s created by human beings and subject to all the flaws and benefits that humanity’s efforts are always subject to—scientists are people too.

The readership for ‘Films from the Future’ spans from the mildly interested science reader to someone like me who’s been writing/blogging about these topics (more or less) for about 10 years. I learned a lot reading this book.

Next time, I’m hopeful there’ll be a next time, Maynard might want to describe the parameters he’s set for his book in more detail that is possible in his chapter headings. He could have mentioned that he’s not a cinéaste so his descriptions of the movies are very much focused on the story as conveyed through words. He doesn’t mention colour palates, camera angles, or, even, cultural lenses.

Take for example, his chapter on ‘Ghost in the Shell’. Focused on the Japanese animation film and not the live action Hollywood version he talks about human enhancement and cyborgs. The Japanese have a different take on robots, inanimate objects, and, I assume, cyborgs than is found in Canada or the US or Great Britain, for that matter (according to a colleague of mine, an Englishwoman who lived in Japan for ten or more years). There’s also the chapter on the Ealing comedy, The Man in The White Suit, an English film from the 1950’s. That too has a cultural (as well as, historical) flavour but since Maynard is from England, he may take that cultural flavour for granted. ‘Never let me go’ in Chapter Two was also a UK production, albeit far more recent than the Ealing comedy and it’s interesting to consider how a UK production about cloning might differ from a US or Chinese or … production on the topic. I am hearkening back to Maynard’s anecdote about movies giving him new ways of seeing and imagining the world.

There’s a corrective. A couple of sentences in Maynard’s introductory chapter cautioning that in depth exploration of ‘cultural lenses’ was not possible without expanding the book to an unreadable size followed by a sentence in each of the two chapters that there are cultural differences.

One area where I had a significant problem was with regard to being “programmed” and having “instinctual” behaviour,

As a species, we are embarrassingly programmed to see “different” as “threatening,” and to take instinctive action against it. It’s a trait that’s exploited in many science fiction novels and movies, including those in this book. If we want to see the rise of increasingly augmented individuals, we need to be prepared for some social strife. (p. 136)

These concepts are much debated in the social sciences and there are arguments for and against ‘instincts regarding strangers and their possible differences’. I gather Dr. Maynard hies to the ‘instinct to defend/attack’ school of thought.

One final quandary, there was no sex and I was expecting it in the Ex Machina chapter, especially now that sexbots are about to take over the world (I exaggerate). Certainly, if you’re talking about “social strife,” then sexbots would seem to be fruitful line of inquiry, especially when there’s talk of how they could benefit families (my August 29, 2018 posting). Again, there could have been a sentence explaining why Maynard focused almost exclusively in this chapter on the discussions about artificial intelligence and superintelligence.

Taken in the context of the book, these are trifling issues and shouldn’t stop you from reading Films from the Future. What Maynard has accomplished here is impressive and I hope it’s just the beginning.

Final note

Bravo Andrew! (Note: We’ve been ‘internet acquaintances/friends since the first year I started blogging. When I’m referring to him in his professional capacity, he’s Dr. Maynard and when it’s not strictly in his professional capacity, it’s Andrew. For this commentary/review I wanted to emphasize his professional status.)

If you need to see a few more samples of Andrew’s writing, there’s a Nov. 15, 2018 essay on The Conversation, Sci-fi movies are the secret weapon that could help Silicon Valley grow up and a Nov. 21, 2018 article on slate.com, The True Cost of Stain-Resistant Pants; The 1951 British comedy The Man in the White Suit anticipated our fears about nanotechnology. Enjoy.

****Added at 1700 hours on Nov. 22, 2018: You can purchase Films from the Future here.

*Nov. 23, 2018: I should have been more specific and said ‘academic scientists’. In Canada, the great percentage of scientists are academic. It’s to the point where the OECD (Organization for Economic Cooperation and Development) has noted that amongst industrialized countries, Canada has very few industrial scientists in comparison to the others.

2018 Canadian Science Policy Conference (Nov. 7 – 9, 2018) highlights and Council of Canadian Academies: a communications job, a report, and more

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This is a going to a science policy heavy posting with both a conference and the latest report from the Canadian Council of Academies (CCA).

2018 Canadian Science Policy Conference

As I noted in my March 1, 2018 posting, this is the fourth year in a row that the conference is being held in Ottawa and the theme for this 10th edition is ‘Building Bridges Between Science, Policy and Society‘.

The dates are November 7 -9, 2018 and as the opening draws closer I’m getting more ‘breathlessly enthusiastic’ announcements. Here are a few highlights from an October 23, 2018 announcement received via email,

CSPC 2018 is honoured to announce that the Honourable Kirsty Duncan, Minister of Science and Sport, will be delivering the keynote speech of the Gala Dinner on Thursday, November 8 at 7:00 PM. Minister Duncan will also hand out the 4th Science Policy Award of Excellence to the winner of this year’s competition.

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CSPC 2018 features 250 speakers, a record number, and above is the breakdown of the positions they hold, over 43% of them being at the executive level and 57% of our speakers being women.

*All information as of October 15, 2018

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If you think that you will not meet any new people at CSPC and all of the registrants are the same as last year, think again!

Over 57% of registrants are attending the conference for the FIRST TIME!

Secure your spot today!

*All information as of October 15, 2018

Here’s more from an October 31, 2018 announcement received via email,

One year after her appointment as Canada’s Chief Science Advisor, Dr. Mona Nemer will discuss her experience with the community. Don’t miss this opportunity.

…

[Canadian Science Policy Centre editorials in advance of conference]

Paul Dufour
“Evidence and Science in Parliament–Looking Back at CSPC and Moving Forward”

Dr. Tom Corr
“Commercializing Innovation in Canada: Advancing in the Right Direction”

Joseph S Sparling, PhD
“Reimagining the Canadian Postdoctoral Training System”

Milton Friesen
“Conspiring Together for Good: Institutional Science and Religion”

Joseph Tafese
“Science and the Next Generation : Science and Inclusivity, Going beyond the Slogans”

Eva Greyeyes
“Opinion Editorial for CSPC, November 2018”

Monique Crichlow
Chris Loken
“Policy Considerations Towards Converged HPC-AI Platforms”

…

Should you be in the Ottawa area November 7 – 9, 2018, it’s still possible to register.

**Update November 6, 2018: The 2018 CSPC is Sold Out!**

Council of Canadian Academies: job and the ‘managing innovation’ report

Let’s start with the job (from the posting),

October 17, 2018

Role Title: Director of Communications
Deadline: November 5, 2018
Salary: $115,000 to $165,000

About the Council of Canadian Academies
The Council of Canadian Academies (CCA) is a not-for-profit organization that conducts assessments of evidence on scientific topics of public interest to inform decision-making in Canada.

Role Summary
The CCA is seeking an experienced communications professional to join its senior management team as Director of Communications. Reporting to the President and CEO, the Director is responsible for developing and implementing a communications plan for the organization that promotes and highlights the CCA’s work, brand, and overall mission to a variety of potential users and stakeholders; overseeing the publication and dissemination of high-quality hard copy and online products; and providing strategic advice to the President and CCA’s Board, Committees, and Panels. In fulfilling these responsibilities, the Director of Communications is expected to work with a variety of interested groups including the media, the broad policy community, government, and non-governmental organizations.

Key Responsibilities and Accountabilities
Under the direction of the President and CEO, the Director leads a small team of communications and publishing professionals to meet the responsibilities and accountabilities outlined below.

Strategy Development and External Communications
• Develop and execute an overall strategic communications plan for the organization that promotes and highlights the CCA’s work, brand, and overall mission.
• Oversee the CCA’s presence and influence on digital and social platforms including the development and execution of a comprehensive content strategy for linking CCA’s work with the broader science and policy ecosystem with a focus on promoting and disseminating the findings of the CCA’s expert panel reports.
• Provide support, as needed for relevant government relations activities including liaising with communications counterparts, preparing briefing materials, responding to requests to share CCA information, and coordinating any appearances before Parliamentary committees or other bodies.
• Harness opportunities for advancing the uptake and use of CCA assessments, including leveraging the strengths of key partners particularly the founding Academies.

Publication and Creative Services
• Oversee the creative services, quality control, and publication of all CCA’s expert panel reports including translation, layout, quality assurance, graphic design, proofreading, and printing processes.
• Oversee the creative development and publication of all CCA’s corporate materials including the Annual Report and Corporate Plan through content development, editing, layout, translation, graphic design, proofreading, and printing processes.

Advice and Issues Management
• Provide strategic advice and support to the President’s Office, Board of Directors, Committees, and CCA staff about increasing the overall impact of CCA expert panel reports, brand awareness, outreach opportunities, and effective science communication.
• Provide support to the President by anticipating project-based or organizational issues, understanding potential implications, and suggesting strategic management solutions.
• Ensure consistent messages, style, and approaches in the delivery of all internal and external communications across the organization.

Leadership
• Mentor, train, and advise up to five communications and publishing staff on a day-to-day basis and complete annual performance reviews and planning.
• Lead the development and implementation of all CCA-wide policy and procedures relating to all aspects of communications and publishing.
• Represent the issues, needs, and ongoing requirements for the communications and publishing staff as a member of the CCA senior management team.

Knowledge Requirements
The Director of Communications requires:
• Superior knowledge of communications and public relations principles – preferably as it applies in a non-profit or academic setting;
• Extensive experience in communications planning and issues management;
• Knowledge of current research, editorial, and publication production standards and procedures including but not limited to: translation, copy-editing, layout/design, proofreading and publishing;
• Knowledge of evaluating impact of reports and assessments;
• Knowledge in developing content strategy, knowledge mobilization techniques, and creative services and design;
• Knowledge of human resource management techniques and experience managing a team;
• Experience in coordinating, organizing and implementing communications activities including those involving sensitive topics;
• Knowledge of the relationships and major players in Canada’s intramural and extramural science and public policy ecosystem, including awareness of federal science departments and Parliamentary committees, funding bodies, and related research groups;
• Knowledge of Microsoft Office Suite, Adobe Creative Suite, WordPress and other related programs;
• Knowledge of a variety of social media platforms and measurement tools.

Skills Requirements
The Director of Communications must have:
• Superior time and project management skills
• Superior writing skills
• Superior ability to think strategically regarding how best to raise the CCA’s profile and ensure impact of the CCA’s expert panel reports
• Ability to be flexible and adaptable; able to respond quickly to unanticipated demands
• Strong advisory, negotiation, and problem-solving skills
• Strong skills in risk mitigation
• Superior ability to communicate in both written and oral forms, effectively and diplomatically
• Ability to mentor, train, and provide constructive feedback to direct reports

Education and Experience
This knowledge and skillset is typically obtained through the completion of a post-secondary degree in Journalism, Communications, Public Affairs or a related field, and/or a minimum of 10
years of progressive and related experience. Experience in an organization that has addressed topics in public policy would be valuable.

Language Requirements: This position is English Essential. Fluency in French is a strong asset.

To apply to this position please send your CV and cover letter to careers@scienceadvice.ca before November 5, 2018. The cover letter should answer the following questions in 1,000 words or less:

1. How does your background and work experience make you well-suited for the position of Director of Communications at CCA?
2. What trends do you see emerging in the communications field generally, and in science and policy communications more specifically? How might CCA take advantage of these trends and developments?
3. Knowing that CCA is in the business of conducting assessments of evidence on important policy topics, how do you feel communicating this type of science differs from communicating other types of information and knowledge?

Improving Innovation Through Better Management

The Council of Canadian Academies released their ‘Improving Innovation Through Better Management‘ report on October 18, 2018..As some of my regular readers (assuming there are some) might have predicted, I have issues.

There’s a distinct disconnection between the described problem and the questions to be answered. From the ‘Improving Innovation Through Better Management‘ summary webpage,

While research is world-class and technology start-ups are thriving, few companies grow and mature in Canada. This cycle — invent and sell, invent and sell — allows other countries to capture much of the economic and social benefits of Canadian-invented products, processes, marketing methods, and business models. …

So, the problem is ‘invent and sell’. Leaving aside the questionable conclusion that other countries are reaping the benefits of Canadian innovation (I’ll get back to that shortly), what questions could you ask about how to break the ‘invent and sell, invent and sell’ cycle? Hmm, maybe we should ask, How do we break the ‘invent and sell’ cycle in Canada?

The government presented two questions to deal with the problem and no, how to break the cycle is not one of the questions. From the ‘Improving Innovation Through Better Management‘ summary webpage,

… Escaping this cycle may be aided through education and training of innovation managers who can systematically manage ideas for commercial success and motivate others to reimagine innovation in Canada.

To understand how to better support innovation management in Canada, Innovation, Science and Economic Development Canada (ISED) asked the CCA two critical questions: What are the key skills required to manage innovation? And, what are the leading practices for teaching these skills in business schools, other academic departments, colleges/polytechnics, and industry?

As lawyers, journalists, scientists, doctors, librarians, and anyone who’s ever received misinformation can tell you, asking the right questions can make a big difference.

As for the conclusion that other countries are reaping the benefits of Canadian innovation, is there any supporting data? We enjoy a very high standard of living and have done so for at least a couple of generations. The Organization for Economic Cooperation and Development (OECD) has a Better Life Index, which ranks well-being on these 11 dimensions (from the OECD Better Life Index entry on Wikipedia), Note: Links have been removed,

Housing: housing conditions and spendings (e.g. real estate pricing)

Income: household income and financial wealth

Jobs: earnings, job security and unemployment

Community: quality of social support network

Education: education and what you get out of it

Environment: quality of environment (e.g. environmental health)

Governance: involvement in democracy

Health

Life Satisfaction: level of happiness

Safety: murder and assault rates

Work-life balance

In 2017, the index ranked Canada as fifth in the world while the US appears to have slipped from a previous ranking of 7th to 8th. (See these Wikipedia entries with relevant subsections for rankings: OECD Better Life Index; Rankings, 2017 ranking and Standard of living in the United States, Measures, 3rd paragraph.)

This notion that other countries are profiting from Canadian innovation while we lag behind has been repeated so often that it’s become an article of faith and I never questioned it until someone else challenged me. This article of faith is repeated internationally and sometimes seems that every country in the world is worried that someone else will benefit from their national innovation.

Getting back to the Canadian situation, we’ve decided to approach the problem by not asking questions about our article of faith or how to break the ‘invent and sell’ cycle. Instead of questioning an assumption and producing an open-ended question, we have these questions (1) What are the key skills required to manage innovation? (2) And, what are the leading practices for teaching these skills in business schools, other academic departments, colleges/polytechnics, and industry?

in my world that first question, would be a second tier question, at best. The second question, presupposes the answer: more training in universities and colleges. I took a look at the report’s Expert Panel webpage and found it populated by five individuals who are either academics or have strong ties to academe. They did have a workshop and the list of participants does include people who run businesses, from the Improving Innovation Through Better Management‘ report (Note: Formatting has not been preserved),

Workshop Participants

Max Blouw,
Former President and Vice-Chancellor of
Wilfrid Laurier University (Waterloo, ON)

Richard Boudreault, FCAE,
Chairman, Sigma Energy
Storage (Montréal, QC)

Judy Fairburn, FCAE,
Past Board Chair, Alberta Innovates;
retired EVP Business Innovation & Chief Digital Officer,
Cenovus Energy Inc. (Calgary, AB)

Tom Jenkins, O.C., FCAE,
Chair of the Board, OpenText
(Waterloo, ON)

Sarah Kaplan,
Director of the Institute for Gender and the
Economy and Distinguished Professor, Rotman School of
Management, University of Toronto (Toronto, ON)

Jean-Michel Lemieux,
Senior Vice President of Engineering,
Shopify Inc. (Ottawa, ON)

Elicia Maine,
Academic Director and Professor, i2I, Beedie
School of Business, Simon Fraser University (Vancouver, BC)

Kathy Malas,
Innovation Platform Manager, CHU
Sainte Justine (Montréal, QC)

John L. Mann, FCAE,
Owner, Mann Consulting
(Blenheim, ON)

Jesse Rodgers,
CEO, Volta Labs (Halifax, NS)

Creso Sá,
Professor of Higher Education and Director of
the Centre for the Study of Canadian and International
Higher Education, Ontario Institute for Studies in Education,
University of Toronto (Toronto, ON)

Dhirendra Shukla,
Professor and Chair, J. Herbert Smith
Centre for Technology Management & Entrepreneurship,
Faculty of Engineering, University of New Brunswick
(Fredericton, NB)

Dan Sinai,
Senior Executive, Innovation, IBM Canada
(Toronto, ON)

Valerie Walker,
Executive Director, Business/Higher
Education Roundtable (Ottawa, ON)

J. Mark Weber,
Eyton Director, Conrad School of
Entrepreneurship & Business, University of Waterloo
(Waterloo, ON)

I am a little puzzled by the IBM executive’s presence (Dan Sinai) on this list. Wouldn’t Canadians holding onto their companies be counterproductive to IBM’s interests? As for John L. Mann, I’ve not been able to find him or his consulting company online. it’s unusual not to find any trace of an individual or company online these days.

In all there were nine individuals representing academic or government institutions in this list. The gender balance is 10 males and five females for the workshop participants and three males and two females for the expert panel. There is no representation from the North or from Manitoba, Saskatchewan, Prince Edward Island, or Newfoundland.

If they’re serious about looking at how to use innovation to drive higher standards of living, why aren’t there any people from Asian countries where they have been succeeding at that very project? South Korea and China come to mind.

I’m sure there are some excellent ideas in the report, I just wish they’d taken their topic to heart and actually tried to approach innovation in Canada in an innovative fashion.

Meanwhile, Vancouver gets another technology hub, from an October 30, 2018 article by Kenneth Chan for the Daily Hive (Vancouver [Canada]), Note: Links have been removed,

Vancouver’s rapidly growing virtual reality (VR) and augmented reality (AR) tech sectors will greatly benefit from a new VR and AR hub created by Launch Academy.

The technology incubator has opened a VR and AR hub at its existing office at 300-128 West Hastings Street in downtown, in partnership with VR/AR Association Vancouver. Immersive tech companies have access to desk space, mentorship programs, VR/AR equipment rentals, investor relations connected to Silicon Valley [emphasis mine], advisory services, and community events and workshops.

…

Within the Vancouver tech industry, the immersive sector has grown from 15 companies working in VR and AR in 2015 to 220 organizations today.

…

Globally, the VR and AR market is expected to hit a value of $108 billion by 2021, with tech giants like Amazon, Apple, Facebook, Google, and Microsoft [emphasis mine] investing billions into product development.

…

In the Vancouver region, the ‘invent and sell’ cycle can be traced back to the 19th century.

One more thing, as I was writing this piece I tripped across this news: “$7.7-billion pact makes Encana more American than Canadian‘ by Geoffrey Morgan. It’s in the Nov. 2, 2018 print edition of the Vancouver Sun’s front page for business. “Encana Corp., the storied Canadian company that had been slowly transitioning away from Canada and natural gas over the past few years under CEO [Chief Executive Officer] Doug Suttles, has pivoted aggressively to US shale basins. … Suttles, formerly as BP Plc. executive, moved from Calgary [Alberta, Canada] to Denver [Colorado, US], though the company said that was for personal reasons and not a precursor to relocation of Encana’s headquarters.” Yes, that’s quite believable. By the way, Suttles has spent* most of his life in the US (Wikipedia entry).

In any event, it’s not just Canadian emerging technology companies that get sold or somehow shifted out of Canada.

So, should we break the cycle and, if so, how are we going to do it?

*’spend’ corrected to ‘spent’ on November 6, 2018.

Xenotransplantation—organs for transplantation in human patients—it’s a business and a science

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The last time (June 18, 2018 post) I mentioned xenotransplantation (transplanting organs from one species into another species; see more here), it was in the context of an art/sci (or sciart) event coming to Vancouver (Canada).,

Patricia Piccinini’s Curious Imaginings Courtesy: Vancouver Biennale [downloaded from http://dailyhive.com/vancouver/vancouver-biennale-unsual-public-art-2018/]

…

The latest edition of the Vancouver Biennale was featured in a June 6, 2018 news item on the Daily Hive (Vancouver),

…

Melbourne artist Patricia Piccinini’s Curious Imaginings is expected to be one of the most talked about installations of the exhibit. Her style of “oddly captivating, somewhat grotesque, human-animal hybrid creature” is meant to be shocking and thought-provoking.

Piccinini’s interactive [emphasis mine] experience will “challenge us to explore the social impacts of emerging biotechnology and our ethical limits in an age where genetic engineering and digital technologies are already pushing the boundaries of humanity.”

Piccinini’s work will be displayed in the 105-year-old Patricia Hotel in Vancouver’s Strathcona neighbourhood. The 90-day ticketed exhibition [emphasis mine] is scheduled to open this September [2018].

…

(The show opens on Sept. 14, 2018.)

At the time, I had yet to stumble across Ingfei Chen’s thoughtful dive into the topic in her May 9, 2018 article for Slate.com,

In the United States, the clock is ticking for more than 114,700 adults and children waiting for a donated kidney or other lifesaving organ, and each day, nearly 20 of them die. Researchers are devising a new way to grow human organs inside other animals, but the method raises potentially thorny ethical issues. Other conceivable futuristic techniques sound like dystopian science fiction. As we envision an era of regenerative medicine decades from now, how far is society willing to go to solve the organ shortage crisis?

I found myself pondering this question after a discussion about the promises of stem cell technologies veered from the intriguing into the bizarre. I was interviewing bioengineer Zev Gartner, co-director and research coordinator of the Center for Cellular Construction at the University of California, San Francisco, about so-called organoids, tiny clumps of organlike tissue that can self-assemble from human stem cells in a Petri dish. These tissue bits are lending new insights into how our organs form and diseases take root. Some researchers even hope they can nurture organoids into full-size human kidneys, pancreases, and other organs for transplantation.

Certain organoid experiments have recently set off alarm bells, but when I asked Gartner about it, his radar for moral concerns was focused elsewhere. For him, the “really, really thought-provoking” scenarios involve other emerging stem cell–based techniques for engineering replacement organs for people, he told me. “Like blastocyst complementation,” he said.

Never heard of it? Neither had I. Turns out it’s a powerful new genetic engineering trick that researchers hope to use for growing human organs inside pigs or sheep—organs that could be genetically personalized for transplant patients, in theory avoiding immune-system rejection problems. The science still has many years to go, but if it pans out, it could be one solution to the organ shortage crisis. However, the prospect of creating hybrid animals with human parts and killing them to harvest organs has already raised a slew of ethical questions. In 2015, the National Institutes of Health placed a moratorium on federal funding of this nascent research area while it evaluated and discussed the issues.

As Gartner sees it, the debate over blastocyst complementation research—work that he finds promising—is just one of many conversations that society needs to have about the ethical and social costs and benefits of future technologies for making lifesaving transplant organs. “There’s all these weird ways that we could go about doing this,” he said, with a spectrum of imaginable approaches that includes organoids, interspecies organ farming, and building organs from scratch using 3D bioprinters. But even if it turns out we can produce human organs in these novel ways, the bigger issue, in each technological instance, may be whether we should.

Gartner crystallized things with a downright creepy example: “We know that the best bioreactor for tissues and organs for humans are human beings,” he said. Hypothetically, “the best way to get you a new heart would be to clone you, grow up a copy of yourself, and take the heart out.” [emphasis mine] Scientists could probably produce a cloned person with the technologies we already have, if money and ethics were of no concern. “But we don’t want to go there, right?” he added in the next breath. “The ethics involved in doing it are not compatible with who we want to be as a society.”

…

This sounds like Gartner may have been reading some science fiction, specifically, Lois McMaster Bujold and her Barrayar series where she often explored the ethics and possibilities of bioengineering. At this point, some of her work seems eerily prescient.

As for Chen’s article, I strongly encourage you to read it in its entirety if you have the time.

Medicine, healing, and big money

At about the same time, there was a May 31, 2018 news item on phys.org offering a perspective from some of the leaders in the science and the business (Note: Links have been removed),

Over the past few years, researchers led by George Church have made important strides toward engineering the genomes of pigs to make their cells compatible with the human body. So many think that it’s possible that, with the help of CRISPR technology, a healthy heart for a patient in desperate need might one day come from a pig.

“It’s relatively feasible to change one gene in a pig, but to change many dozens—which is quite clear is the minimum here—benefits from CRISPR,” an acronym for clustered regularly interspaced short palindromic repeats, said Church, the Robert Winthrop Professor of Genetics at Harvard Medical School (HMS) and a core faculty member of Harvard’s Wyss Institute for Biologically Inspired Engineering. Xenotransplantation is “one of few” big challenges (along with gene drives and de-extinction, he said) “that really requires the ‘oomph’ of CRISPR.”

To facilitate the development of safe and effective cells, tissues, and organs for future medical transplantation into human patients, Harvard’s Office of Technology Development has granted a technology license to the Cambridge biotech startup eGenesis.

Co-founded by Church and former HMS doctoral student Luhan Yang in 2015, eGenesis announced last year that it had raised $38 million to advance its research and development work. At least eight former members of the Church lab—interns, doctoral students, postdocs, and visiting researchers—have continued their scientific careers as employees there.

“The Church Lab is well known for its relentless pursuit of scientific achievements so ambitious they seem improbable—and, indeed, [for] its track record of success,” said Isaac Kohlberg, Harvard’s chief technology development officer and senior associate provost. “George deserves recognition too for his ability to inspire passion and cultivate a strong entrepreneurial drive among his talented research team.”

The license from Harvard OTD covers a powerful set of genome-engineering technologies developed at HMS and the Wyss Institute, including access to foundational intellectual property relating to the Church Lab’s 2012 breakthrough use of CRISPR, led by Yang and Prashant Mali, to edit the genome of human cells. Subsequent innovations that enabled efficient and accurate editing of numerous genes simultaneously are also included. The license is exclusive to eGenesis but limited to the field of xenotransplantation.

A May 30, 2018 Harvard University news release by Caroline Petty, which originated the news item, explores some of the issues associated with incubating humans organs in other species,

The prospect of using living, nonhuman organs, and concerns over the infectiousness of pathogens either present in the tissues or possibly formed in combination with human genetic material, have prompted the Food and Drug Administration to issue detailed guidance on xenotransplantation research and development since the mid-1990s. In pigs, a primary concern has been that porcine endogenous retroviruses (PERVs), strands of potentially pathogenic DNA in the animals’ genomes, might infect human patients and eventually cause disease. [emphases mine]

That’s where the Church lab’s CRISPR expertise has enabled significant advances. In 2015, the lab published important results in the journal Science, successfully demonstrating the use of genome engineering to eliminate all 62 PERVs in porcine cells. Science later called it “the most widespread CRISPR editing feat to date.”

In 2017, with collaborators at Harvard, other universities, and eGenesis, Church and Yang went further. Publishing again in Science, they first confirmed earlier researchers’ fears: Porcine cells can, in fact, transmit PERVs into human cells, and those human cells can pass them on to other, unexposed human cells. (It is still unknown under what circumstances those PERVs might cause disease.) In the same paper, they corrected the problem, announcing the embryogenesis and birth of 37 PERV-free pigs. [Note: My July 17, 2018 post features research which suggests CRISPR-Cas9 gene editing may cause greater genetic damage than had been thought.]

“Taken together, those innovations were stunning,” said Vivian Berlin, director of business development in OTD, who manages the commercialization strategy for much of Harvard’s intellectual property in the life sciences. “That was the foundation they needed, to convince both the scientific community and the investment community that xenotransplantation might become a reality.”

“After hundreds of tests, this was a critical milestone for eGenesis — and the entire field — and represented a key step toward safe organ transplantation from pigs,” said Julie Sunderland, interim CEO of eGenesis. “Building on this study, we hope to continue to advance the science and potential of making xenotransplantation a safe and routine medical procedure.”

Genetic engineering may undercut human diseases, but also could help restore extinct species, researcher says. [Shades of the Jurassic Park movies!]

It’s not, however, the end of the story: An immunological challenge remains, which eGenesis will need to address. The potential for a patient’s body to outright reject transplanted tissue has stymied many previous attempts at xenotransplantation. Church said numerous genetic changes must be achieved to make porcine organs fully compatible with human patients. Among these are edits to several immune functions, coagulation functions, complements, and sugars, as well as the PERVs.

“Trying the straight transplant failed almost immediately, within hours, because there’s a huge mismatch in the carbohydrates on the surface of the cells, in particular alpha-1-3-galactose, and so that was a showstopper,” Church explained. “When you delete that gene, which you can do with conventional methods, you still get pretty fast rejection, because there are a lot of other aspects that are incompatible. You have to take care of each of them, and not all of them are just about removing things — some of them you have to humanize. There’s a great deal of subtlety involved so that you get normal pig embryogenesis but not rejection.

“Putting it all together into one package is challenging,” he concluded.

In short, it’s the next big challenge for CRISPR.

Not unexpectedly, there is no mention of the CRISPR patent fight between Harvard/MIT’s (Massachusetts Institute of Technology) Broad Institute and the University of California at Berkeley (UC Berkeley). My March 15, 2017 posting featured an outcome where the Broad Institute won the first round of the fight. As I recall, it was a decision based on the principles associated with King Solomon, i.e., the US Patent Office, divided the baby and UCBerkeley got the less important part of the baby. As you might expect the decision has been appealed. In an April 30, 2018 piece, Scientific American reprinted an article about the latest round in the fight written by Sharon Begley for STAT (Note: Links have been removed),

All You Need to Know for Round 2 of the CRISPR Patent Fight

It’s baaaaack, that reputation-shredding, stock-moving fight to the death over key CRISPR patents. On Monday morning in Washington, D.C., the U.S. Court of Appeals for the Federal Circuit will hear oral arguments in University of California v. Broad Institute. Questions?

How did we get here? The patent office ruled in February 2017 that the Broad’s 2014 CRISPR patent on using CRISPR-Cas9 to edit genomes, based on discoveries by Feng Zhang, did not “interfere” with a patent application by UC based on the work of UC Berkeley’s Jennifer Doudna. In plain English, that meant the Broad’s patent, on using CRISPR-Cas9 to edit genomes in eukaryotic cells (all animals and plants, but not bacteria), was different from UC’s, which described Doudna’s experiments using CRISPR-Cas9 to edit DNA in a test tube—and it was therefore valid. The Patent Trial and Appeal Board concluded that when Zhang got CRISPR-Cas9 to work in human and mouse cells in 2012, it was not an obvious extension of Doudna’s earlier research, and that he had no “reasonable expectation of success.” UC appealed, and here we are.

…

For anyone who may not realize what the stakes are for these institutions, Linda Williams in a March 16, 1999 article for the LA Times had this to say about universities, patents, and money,

The University of Florida made about $2 million last year in royalties on a patent for Gatorade Thirst Quencher, a sports drink that generates some $500 million to $600 million a year in revenue for Quaker Oats Co.

The payments place the university among the top five in the nation in income from patent royalties.

Oh, but if some people on the Gainesville, Fla., campus could just turn back the clock. “If we had done Gatorade right, we would be getting $5 or $6 million (a year),” laments Donald Price, director of the university’s office of corporate programs. “It is a classic example of how not to handle a patent idea,” he added.

Gatorade was developed in 1965 when many universities were ill equipped to judge the commercial potential of ideas emerging from their research labs. Officials blew the university’s chance to control the Gatorade royalties when they declined to develop a professor’s idea.

…

The Gatorade story does not stop there and, even though it’s almost 20 years old, this article stands the test of time. I strongly encourage you to read it if the business end of patents and academia interest you or if you would like to develop more insight into the Broad Institute/UC Berkeley situation.

Getting back to the science, there is that pesky matter of diseases crossing over from one species to another. While, Harvard and eGenesis claim a victory in this area, it seems more work needs to be done.

Infections from pigs

An August 29, 2018 University of Alabama at Birmingham news release (also on EurekAlert) by Jeff Hansen, describes the latest chapter in the quest to provide more organs for transplantion,

A shortage of organs for transplantation — including kidneys and hearts — means that many patients die while still on waiting lists. So, research at the University of Alabama at Birmingham and other sites has turned to pig organs as an alternative. [emphasis mine]

Using gene-editing, researchers have modified such organs to prevent rejection, and research with primates shows the modified pig organs are well-tolerated.

An added step is needed to ensure the safety of these inter-species transplants — sensitive, quantitative assays for viruses and other infectious microorganisms in donor pigs that potentially could gain access to humans during transplantation.

The U.S. Food and Drug Administration requires such testing, prior to implantation, of tissues used for xenotransplantation from animals to humans. It is possible — though very unlikely — that an infectious agent in transplanted tissues could become an emerging infectious disease in humans.

In a paper published in Xenotransplantation, Mark Prichard, Ph.D., and colleagues at UAB have described the development and testing of 30 quantitative assays for pig infectious agents. These assays had sensitivities similar to clinical lab assays for viral loads in human patients. After validation, the UAB team also used the assays on nine sows and 22 piglets delivered from the sows through caesarian section.

“Going forward, ensuring the safety of these organs is of paramount importance,” Prichard said. “The use of highly sensitive techniques to detect potential pathogens will help to minimize adverse events in xenotransplantation.”

“The assays hold promise as part of the screening program to identify suitable donor animals, validate and release transplantable organs for research purposes, and monitor transplant recipients,” said Prichard, a professor in the UAB Department of Pediatrics and director of the Department of Pediatrics Molecular Diagnostics Laboratory.

The UAB researchers developed quantitative polymerase chain reaction, or qPCR, assays for 28 viruses sometimes found in pigs and two groups of mycoplasmas. They established reproducibility, sensitivity, specificity and lower limit of detection for each assay. All but three showed features of good quantitative assays, and the lower limit of detection values ranged between one and 16 copies of the viral or bacterial genetic material.

Also, the pig virus assays did not give false positives for some closely related human viruses.

As a start to understanding the infectious disease load in normal healthy animals and ensuring the safety of pig tissues used in xenotransplantation research, the researchers then screened blood, nasal swab and stool specimens from nine adult sows and 22 of their piglets delivered by caesarian section.

Mycoplasma species and two distinct herpesviruses were the most commonly detected microorganisms. Yet 14 piglets that were delivered from three sows infected with either or both herpesviruses were not infected with the herpesviruses, showing that transmission of these viruses from sow to the caesarian-delivery piglet was inefficient.

Prichard says the assays promise to enhance the safety of pig tissues for xenotransplantation, and they will also aid evaluation of human specimens after xenotransplantation.

The UAB researchers say they subsequently have evaluated more than 300 additional specimens, and that resulted in the detection of most of the targets. “The detection of these targets in pig specimens provides reassurance that the analytical methods are functioning as designed,” said Prichard, “and there is no a priori reason some targets might be more difficult to detect than others with the methods described here.”

As is my custom, here’s a link to and a citation for the paper,

Xenotransplantation panel for the detection of infectious agents in pigs by Caroll B. Hartline, Ra’Shun L. Conner, Scott H. James, Jennifer Potter, Edward Gray, Jose Estrada, Mathew Tector, A. Joseph Tector, Mark N. Prichard. Xenotransplantaion Volume 25, Issue 4 July/August 2018 e12427 DOI: https://doi.org/10.1111/xen.12427 First published: 18 August 2018

This paper is open access.

All this leads to questions about chimeras. If a pig is incubating organs with human cells it’s a chimera but then means the human receiving the organ becomes a chimera too. (For an example, see my Dec. 22, 2013 posting where there’s mention of a woman who received a trachea from a pig. Scroll down about 30% of the way.)

What is it to be human?

A question much beloved of philosophers and others, the question seems particularly timely with xenotransplantion and other developments such neuroprosthetics (cyborgs) and neuromorphic computing (brainlike computing).

As I’ve noted before, although not recently, popular culture offers a discourse on these issues. Take a look at the superhero movies and the way in which enhanced humans and aliens are presented. For example, X-Men comics and movies present mutants (humans with enhanced abilities) as despised and rejected. Video games (not really my thing but there is the Deus Ex series which has as its hero, a cyborg also offer insight into these issues.

Other than popular culture and in the ‘bleeding edge’ arts community, I can’t recall any public discussion on these matters arising from the extraordinary set of technologies which are being deployed or prepared for deployment in the foreseeable future.

(If you’re in Vancouver (Canada) from September 14 – December 15, 2018, you may want to check out Piccinini’s work. Also, there’s ” NCSU [North Carolina State University] Libraries, NC State’s Genetic Engineering and Society (GES) Center, and the Gregg Museum of Art & Design have issued a public call for art for the upcoming exhibition Art’s Work in the Age of Biotechnology: Shaping our Genetic Futures.” from my Sept. 6, 2018 posting. Deadline: Oct. 1, 2018.)

At a guess, there will be pushback from people who have no interest in debating what it is to be human as they already know, and will find these developments, when they learn about them, to be horrifying and unnatural.

AI (artificial intelligence) for Good Global Summit from May 15 – 17, 2018 in Geneva, Switzerland: details and an interview with Frederic Werner

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With all the talk about artificial intelligence (AI), a lot more attention seems to be paid to apocalyptic scenarios: loss of jobs, financial hardship, loss of personal agency and privacy, and more with all of these impacts being described as global. Still, there are some folks who are considering and working on ‘AI for good’.

If you’d asked me, the International Telecommunications Union (ITU) would not have been my first guess (my choice would have been United Nations Educational, Scientific and Cultural Organization [UNESCO]) as an agency likely to host the 2018 AI for Good Global Summit. But, it turns out the ITU is a UN (United Nations agency) and, according to its Wikipedia entry, it’s an intergovernmental public-private partnership, which may explain the nature of the participants in the upcoming summit.

The news

First, there’s a May 4, 2018 ITU media advisory (received via email or you can find the full media advisory here) about the upcoming summit,

Artificial Intelligence (AI) is now widely identified as being able to address the greatest challenges facing humanity – supporting innovation in fields ranging from crisis management and healthcare to smart cities and communications networking.

The second annual ‘AI for Good Global Summit’ will take place 15-17 May [2018] in Geneva, and seeks to leverage AI to accelerate progress towards the United Nations’ Sustainable Development Goals and ultimately benefit humanity.

WHAT: Global event to advance ‘AI for Good’ with the participation of internationally recognized AI experts. The programme will include interactive high-level panels, while ‘AI Breakthrough Teams’ will propose AI strategies able to create impact in the near term, guided by an expert audience of mentors representing government, industry, academia and civil society – through interactive sessions. The summit will connect AI innovators with public and private-sector decision-makers, building collaboration to take promising strategies forward.

A special demo & exhibit track will feature innovative applications of AI designed to: protect women from sexual violence, avoid infant crib deaths, end child abuse, predict oral cancer, and improve mental health treatments for depression – as well as interactive robots including: Alice, a Dutch invention designed to support the aged; iCub, an open-source robot; and Sophia, the humanoid AI robot.

WHEN: 15-17 May 2018, beginning daily at 9 AM

WHERE: ITU Headquarters, 2 Rue de Varembé, Geneva, Switzerland (Please note: entrance to ITU is now limited for all visitors to the Montbrillant building entrance only on rue Varembé).

WHO: Confirmed participants to date include expert representatives from: Association for Computing Machinery, Bill and Melinda Gates Foundation, Cambridge University, Carnegie Mellon, Chan Zuckerberg Initiative, Consumer Trade Association, Facebook, Fraunhofer, Google, Harvard University, IBM Watson, IEEE, Intellectual Ventures, ITU, Microsoft, Massachusetts Institute of Technology (MIT), Partnership on AI, Planet Labs, Shenzhen Open Innovation Lab, University of California at Berkeley, University of Tokyo, XPRIZE Foundation, Yale University – and the participation of “Sophia” the humanoid robot and “iCub” the EU open source robotcub.

The interview

Frederic Werner, Senior Communications Officer at the International Telecommunication Union and** one of the organizers of the AI for Good Global Summit 2018 kindly took the time to speak to me and provide a few more details about the upcoming event.

Werner noted that the 2018 event grew out of a much smaller 2017 ‘workshop’ and first of its kind, about beneficial AI which this year has ballooned in size to 91 countries (about 15 participants are expected from Canada), 32 UN agencies, and substantive representation from the private sector. The 2017 event featured Dr. Yoshua Bengio of the University of Montreal (Université de Montréal) was a featured speaker.

“This year, we’re focused on action-oriented projects that will help us reach our Sustainable Development Goals (SDGs) by 2030. We’re looking at near-term practical AI applications,” says Werner. “We’re matchmaking problem-owners and solution-owners.”

Academics, industry professionals, government officials, and representatives from UN agencies are gathering to work on four tracks/themes:

AI and satellite imagery
AI and health
AI and smart cities & communities
Trust in AI

In advance of this meeting, the group launched an AI repository (an action item from the 2017 meeting) on April 25, 2018 inviting people to list their AI projects (from the ITU’s April 25, 2018? AI repository news announcement),

ITU has just launched an AI Repository where anyone working in the field of artificial intelligence (AI) can contribute key information about how to leverage AI to help solve humanity’s greatest challenges.

This is the only global repository that identifies AI-related projects, research initiatives, think-tanks and organizations that aim to accelerate progress on the 17 United Nations’ Sustainable Development Goals (SDGs).

To submit a project, just press ‘Submit’ on the AI Repository site and fill in the online questionnaire, providing all relevant details of your project. You will also be asked to map your project to the relevant World Summit on the Information Society (WSIS) action lines and the SDGs. Approved projects will be officially registered in the repository database.

Benefits of participation on the AI Repository include:

Your project details will become visible to the world on the website.

You will be connected with AI stakeholders, world-wide.

You will be eligible for the World Summit on the Information Society (WSIS) Prizes.

WSIS Prizes recognize individuals, governments, civil society, local, regional and international agencies, research institutions and private-sector companies for outstanding success in implementing development oriented strategies that leverage the power of AI and ICTs.

Creating the AI Repository was one of the action items of last year’s AI for Good Global Summit.

We are looking forward to your submissions.

If you have any questions, please send an email to: ai@itu.int

“Your project won’t be visible immediately as we have to vet the submissions to weed out spam-type material and projects that are not in line with our goals,” says Werner. That said, there are already 29 projects in the repository. As you might expect, the UK, China, and US are in the repository but also represented are Egypt, Uganda, Belarus, Serbia, Peru, Italy, and other countries not commonly cited when discussing AI research.

Werner also pointed out in response to my surprise over the ITU’s role with regard to this AI initiative that the ITU is the only UN agency which has 192* member states (countries), 150 universities, and over 700 industry members as well as other member entities, which gives them tremendous breadth of reach. As well, the organization, founded originally in 1865 as the International Telegraph Convention, has extensive experience with global standardization in the information technology and telecommunications industries. (See more in their Wikipedia entry.)

Finally

There is a bit more about the summit on the ITU’s AI for Good Global Summit 2018 webpage,

The 2nd edition of the AI for Good Global Summit will be organized by ITU in Geneva on 15-17 May 2018, in partnership with XPRIZE Foundation, the global leader in incentivized prize competitions, the Association for Computing Machinery (ACM) and sister United Nations agencies including UNESCO, UNICEF, UNCTAD, UNIDO, Global Pulse, UNICRI, UNODA, UNIDIR, UNODC, WFP, IFAD, UNAIDS, WIPO, ILO, UNITAR, UNOPS, OHCHR, UN University, WHO, UNEP, ICAO, UNDP, The World Bank, UN DESA, CTBTO, UNISDR, UNOG, UNOOSA, UNFPA, UNECE, UNDPA, and UNHCR.

The AI for Good series is the leading United Nations platform for dialogue on AI. The action-oriented 2018 summit will identify practical applications of AI and supporting strategies to improve the quality and sustainability of life on our planet. The summit will continue to formulate strategies to ensure trusted, safe and inclusive development of AI technologies and equitable access to their benefits.

While the 2017 summit sparked the first ever inclusive global dialogue on beneficial AI, the action-oriented 2018 summit will focus on impactful AI solutions able to yield long-term benefits and help achieve the Sustainable Development Goals. ‘Breakthrough teams’ will demonstrate the potential of AI to map poverty and aid with natural disasters using satellite imagery, how AI could assist the delivery of citizen-centric services in smart cities, and new opportunities for AI to help achieve Universal Health Coverage, and finally to help achieve transparency and explainability in AI algorithms.

Teams will propose impactful AI strategies able to be enacted in the near term, guided by an expert audience of mentors representing government, industry, academia and civil society. Strategies will be evaluated by the mentors according to their feasibility and scalability, potential to address truly global challenges, degree of supporting advocacy, and applicability to market failures beyond the scope of government and industry. The exercise will connect AI innovators with public and private-sector decision-makers, building collaboration to take promising strategies forward.

“As the UN specialized agency for information and communication technologies, ITU is well placed to guide AI innovation towards the achievement of the UN Sustainable Development Goals. We are providing a neutral close quotation markplatform for international dialogue aimed at building a common understanding of the capabilities of emerging AI technologies.” Houlin Zhao, Secretary General of ITU

Should you be close to Geneva, it seems that registration is still open. Just go to the ITU’s AI for Good Global Summit 2018 webpage, scroll the page down to ‘Documentation’ and you will find a link to the invitation and a link to online registration. Participation is free but I expect that you are responsible for your travel and accommodation costs.

For anyone unable to attend in person, the summit will be livestreamed (webcast in real time) and you can watch the sessions by following the link below,

https://www.itu.int/en/ITU-T/AI/2018/Pages/webcast.aspx

For those of us on the West Coast of Canada and other parts distant to Geneva, you will want to take the nine hour difference between Geneva (Switzerland) and here into account when viewing the proceedings. If you can’t manage the time difference, the sessions are being recorded and will be posted at a later date.

*’132 member states’ corrected to ‘192 member states’ on May 11, 2018 at 1500 hours PDT.

*Redundant ‘and’ removed on July 19, 2018.

“Innovation and its enemies” and “Science in Wonderland”: a commentary on two books and a few thoughts about fish (2 of 2)

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Part 1 featured my commentary on both Calestous Juma’s 2016 book, ”Innovation and Its Enemies; Why People Resist New Technologies” and Meanie Keene’s 2015 book, “Science in Wonderland; The scientific fairy tales of Victorian Britain.” Now for an emerging technology; genetically modified fish (AquAdvantage salmon) and my final comments on the books and the contrasting ways the adoption of new technologies and science is presented.

Fish

AquAdvanage salmon features as one of Calestous Juma’s contemporary emerging technologies. I mentioned the fish here in a May 20, 2016 posting when the fish was approved for consumption in Canada; this followed an earlier mention in a Dec. 4, 2015 posting when the US Food and Drug Administration (FDA) approved the salmon for consumption in the US (from the 2015 posting),

…

For the final excerpt from the December 2015 issue, there’s this about genetically engineered salmon,

Genetically Modified Salmon: Coming to a River Near You?
After nearly 20 years of effort, the Food and Drug Administration has approved genetically engineered salmon produced by AquaBounty Technologies, as fit for consumption and will not have to be labeled as genetically engineered. This salmon is capable of growing twice as fast as a non-engineered farmed salmon in as little as half of the time, however, it’s still likely to be at least two years before these salmon reach supermarkets. Some groups are concerned about the environmental implications should these salmon accidentally get released, or escape, into the wild, even though AquaBounty says its salmon will be all female and sterile.

AquaBounty’s salmon (background) has been genetically modified to grow bigger and faster than a conventional Atlantic salmon of the same age (foreground.) Courtesy of AquaBounty Technologies, Inc. [downloaded from http://www.npr.org/sections/thesalt/2015/06/24/413755699/genetically-modified-salmon-coming-to-a-river-near-you]

The link from the newsletter points to a June 24, 2015 article by Jessie Rack for US National Public Radio’s Salt on the Table program (Note: Links have been removed),

One concern repeatedly raised by critics who don’t want the FDA to give the transgenic fish the green light: What would happen if these fish got out of the land-based facilities where they’re grown and escaped into the wild? Would genetically modified salmon push out their wild counterparts or permanently alter habitat? In a review paper published this month in the journal BioScience, scientists tackle that very question.

Robert H. Devlin, a scientist at Fisheries and Oceans Canada, led a team that reviewed more than 80 studies analyzing growth, behavior and other trait differences between genetically modified and unaltered fish. The scientists used this to predict what might happen if fish with modified traits were unleashed in nature.

Genetically modified salmon contain the growth hormone gene from one fish, combined with the promoter of an antifreeze gene from another. This combination both increases and speeds up growth, so the salmon grow faster.

Altering a fish’s genes also changes other traits, the review found. Genetically modified salmon eat more food, spend more time near the surface of the water, and don’t tend to associate in groups. They develop at a dramatically faster rate, and their immune function is reduced.

But would these altered traits help genetically modified salmon outcompete wild salmon, while at the same time making them less likely to thrive in nature? It’s unclear, says Fredrik Sundström, one of the study authors and an ecologist at Uppsala University in Sweden.

You may note the lead researcher for the literature review, a Canadian scientist was not quoted. This is likely due to the muzzle the Conservative government (still in power in June 2015 ) had applied to government scientists.

One last thing about AquAdvantage salmon, there is a very good Dec. 3, 2015 posting by Meredith Hamel focusing on their Canadian connections on her BiologyBizarre blog/magazine (Note: A link has been removed),

“For the first time anywhere in the world, a genetically engineered animal has been approved for human consumption” announced Peter Mansbridge on CBC [Canadian Broadcasting Corporation] news on November 20 [2015]. Members of society do not agree on how genetically modified fruits and vegetables should be labelled, if at all, but we are already moving on to genetically modified animals for human consumption. The AquAdvantage salmon by the US company AquaBounty can grow quicker and go to market twice as fast as regular farmed salmon using less feed. This genetically engineered salmon, whose fertilized eggs are produced at an inland facility in P.E.I [Prince Edward Island], Canada [emphasis mine] and raised at a facility in Panama, has been approved by the FDA after a long 20 year wait. AquAdvantage salmon could be the first genetically engineered meat we eat but opposition to approving it in Canada shows this salmon is not yet finished swimming against the current.

She goes on to describe in detail how these salmon are created (not excerpted here) and pinpoints another Canadian connection and political ramifications (Note: Links have been removed),

Head of Ocean Sciences Department at Memorial University [province of Newfoundland and Labrador], Garth Fletcher told The Star he was happy to see his creation get approved as he didn’t think approval would happen in his lifetime. Fletcher is no longer involved with AquaBounty but began working on this growth improved transgenic fish with other scientists back in 1982. On CBC news he said “the risk is as minimal as you could ever expect to get with any product.”

While the salmon is not approved in Canada for human consumption, some grocery store chains have already boycotted AquAdvantage salmon. The first step, the production of eggs in P.E.I has been approved by the federal government. Now there is a court battle with British Columbia’s Living Oceans Society and Nova Scotia’s Ecology Action Centre together challenging the federal government’s approval. They are concerned AquAdvantage salmon would be toxic to the environment as an invasive species if they were to escape and that this was not adequately assessed. Secondly they argue that Environment Canada had a duty to inform the public but failed to do so.

Natalie Huneault at Environment Canada told the National Oberver, “there were no concerns identified to the environment or to the indirect health of Canadians due to the contained production of these GM fish eggs for export.”

Anastasia Bodnar over on Biology Fortified does an excellent job of going through the risks and mitigation of AquAdvantage salmon (here and here) both with respect to safety of eating this meat product as well as in preventing escapee transgenic fish from contaminating wild salmon populations. The Fisheries and Oceans Canada document containing assessment of risks to the environment and health are found here. Due to the containment facility and procedures there is extremely low likelihood that any fertile genetically modified salmon would escape to an area where it could survive and reproduce.

The failure of Environment Canada to properly inform and have a discussion with the public before approving the P.E.I fertilized egg production facility will certainly have increased public mistrust and fear of this genetically engineered salmon. I think that if the public feel that this step has already taken place behind their back, future discussion about approving genetically engineered salmon as safe to eat, is only going to be met with suspicion.

…

Since the 2016 approval, AquAdvantage salmon, 4.5M tonnes has been sold in Canada according to an Aug. 8, 2017 article by Sima Shakeri for Huffington Post (Note: Links have been removed),

After decades of trying to get approval by in North America, genetically modified Atlantic salmon has been sold to consumers in Canada.

AquaBounty Technologies, an American company that produces the Atlantic salmon, confirmed it had sold 4.5 tonnes of the modified fish on August 4 [2017], the Scientific American reported.

The fish have been engineered with a growth hormone gene from Chinook salmon to grow faster than regular salmon and require less food. They take about 18 months to reach market size, which is much quicker than the 30 months or so for conventional salmon.

The Washington Post wrote AquaBounty’s salmon also contains a gene from the ocean pout that makes the salmon produce the growth hormone gene all-year-round.

The company produces the eggs in a facility in P.E.I., which is currently being expanded, and then they’re shipped to Panama where the fish are raised.

Health Canada assessed the AquAdvantage salmon and concluded it “did not pose a greater risk to human health than salmon currently available on the Canadian market,” and that it would have no impact on allergies nor a difference in nutritional value compared to other farmed salmon.

Because of that, the AquAdvantage product is not required to be specially labelled as genetically modified, and is up to the discretion of retailers.

Scientific American has reproduced a piece by Emily Waltz (originally published August 4, 2017, the date Canadian consumers discovered the fish was being sold, in Nature). From the Aug. 7, 2017 Scientific American republication (Note: A link has been removed),

AquaBounty’s gruelling path from scientific discovery to market terrified others working in animal biotechnology, and almost put the company out of business on several occasions. Scientists first demonstrated the fast-growing fish in 1989. They gave it a growth-hormone gene from Chinook salmon (Oncorhynchus tshawytscha), along with genetic regulatory elements from a third species, the ocean pout (Zoarces americanus). The genetic modifications enable the salmon to produce a continuous low level of growth hormone.

AquaBounty formed around the technology in the early 1990s and approached regulators in the United States soon after. It then spent almost 25 years in regulatory limbo. The US Food and Drug Administration (FDA) approved the salmon for consumption in November 2015, and Canadian authorities came to the same decision six months later. Neither country requires the salmon to be labelled as genetically engineered.

But unlike in Canada, political battles in the United States have stalled the salmon’s entry into the marketplace. …

Activists in both the United States and Canada have demanded that regulators reconsider their decisions, and some have filed lawsuits. …

Waltz includes this quote from an interested party,

The sale of the fish follows a long, hard-fought battle to navigate regulatory systems and win consumer acceptance. “Somebody’s got to be first and I’m glad it was them and not me,” says James West, a geneticist at Vanderbilt University in Nashville, Tennessee, who co-founded AgGenetics, a start-up company in Nashville that is engineering cattle for the dairy and beef industries. “If they had failed, it might have killed the engineered livestock industry for a generation,” he says.

Canadians don’t necessarily respond in the same way that Americans do. The stem cell controversies to the south of us never reached the same fury and pitch although there were some significant impacts felt by the research community. Similarly the GMO (genetically modified organisms) controversies were felt here but in nowhere near the same degree as Europe. That doesn’t mean there won’t be problems this time but trying to determine how Canadians are likely to respond can be tricky especially when most of us don’t know much about GMO foods as Meham Abedi notes in her August 9, 2017 article for Global TV news (Note: Link have been removed),

On Wednesday [Aug. 9, 2017], an Angus Reid survey revealed that most Canadians admit they don’t know much about genetically modified organisms, but still want more transparency.

Of the 1,512 respondents, 24 per cent said they had “never heard of them” or only heard the term, 60 per cent said they “know a little bit about” GMO food, while only 16 per cent were “very familiar” with what it entails.

However, 83 per cent of Canadians surveyed said at least some GMO food labelling should [be] mandatory in grocery stores.

The report echos 2016 Health Canada findings that Canadians’ opinions on the products were defined by “confusion, misinformation, and generally low awareness/understanding.”

…

The Angus Reid survey was conducted between June 8-13, 2017 [emphasis mine], by 1,512 Canadian adults. It is considered accurate +/- 2.5 percentage points, 19 times out of 20.

It’s hard to know how “confusion, misinformation, and generally low awareness/understanding,” is going to play out but it doesn’t seem a good idea to just sneak GMO salmon into the Canadian marketplace. Notably, Juma argues for more public education in his book and while it might not smooth the path as much as he and other innovation enthusiasts might prefer, it certainly couldn’t hurt.

It might also be useful to consider the idea that not all resistance is bad and to be avoided. Tess Doezema in her April 26, 2017 article (Skepticism About Biotechnology Isn’t Anti-Science) presents a persuasive argument suggesting that public concerns don’t deserve to be dismissed (Note: Links have been removed),

…

To many in bioscience and biotechnology circles, this [AquAdvantage salmon] is a case of politics contaminating science. In an open letter to President Obama in 2014, a group of “concerned international scientists and global technology company executives” argue this point:

The American people, and indeed all people everywhere, are best served by a trusted objective regulatory process truly based on sound science, a system which can be counted upon to evaluate and act on the applications it receives without fear of political interference.

These scientists and others offer a picture of a Manichean world divided into those who are for scientific and technological progress and those who are against it—a representation of the world that we have been seeing more and more of lately in reports of a “war on science.” But drawing this line is dangerous. The real problem here is the regulatory process itself, which forces dissent to take the narrow form of challenges to scientific data and methodology and ignores other questions about what’s at stake.

The FDA approval process for the AquAdvantage salmon took longer and included more opportunities for public comment than most products the FDA reviews. This unique openness to public input was balanced by a careful parsing of what counts as scientifically and contextually relevant and what does not. The agency received 38,000 comments in response to its draft assessment alone, but it determined that just 90 were worth considering [emphases mine]. The remaining comments were discounted as irrelevant because they did not directly address the details of the regulation process, or they raised issues beyond the mandate of the agency. These disregarded comments focused on a wide range of concerns, including patenting and ownership regimes of seed and crops; how deploying genetically modified corn and soy would affect the United States’ image around the world; continuing failures of existing market configurations to address inequality and food distribution; and the long history of multinational corporations central to the commercialization of biotechnologies, such as Monsanto, intentionally obscuring the negative impacts of their chemical products and byproducts while undermining human health.

…

Some might read the vast public preoccupation with a broad set of social, political, and economic issues as the contamination of science with politics. But I would suggest that this is actually a case of the reverse problem: seemingly endless conflict around the AquAdvantage salmon reflects the limitation of using narrow scientific terms to address questions of broad social, political, and economic significance. As things stand, the only legitimate way to engage in debates about the entry of the AquAdvantage salmon and other genetically modified organisms into our environments, meals, intellectual property regimes, and beyond is to contest its approval at the level of regulatory science. When the system asks the public to limit objections to narrow technical concerns, it undermines regulatory legitimacy and stultifies democratic debate—and perhaps most importantly, it contributes to the problematic discourse around science itself. When our modes of public deliberation strictly define what counts as a legitimate view on these issues, we end up portraying a good portion of the population as “against science,” when that in fact could not be further from the truth.

…

To position science on one side of these debates is not only patently false but detrimental to public discourse.

… Synthetic biology is billed as having the potential to transform the world in a way that will disrupt prevailing economic and geopolitical paradigms and “reshape the very fabric of life.” The one thing both sides of the fishy debate seem to agree on is that the AquAdvantage salmon is a “pioneer” technology, and what happens to this fish could set the stage for the role that biotechnology will play in our food system in the century to come. As one commentator opined for the New York Times:

We should all be rooting for the agency to do the right thing and approve the AquAdvantage salmon. It’s a healthy and relatively cheap food source that, as global demand for fish increases, can take some pressure off our wild fish stocks. But most important, a rejection will have a chilling effect on biotechnological innovation in this country. …

This framing suggests that biotechnological innovation is a necessary and unmitigated good. But for many, the prospect of a world radically altered by biotechnology conjures past experiences in which scientific “progress” didn’t go as planned—like the devastation and political instability ushered in by nuclear weapons. Similarly, to some, a dam looks like progress, development, and economic prosperity. But to others, it looks like the violent end of a way of life, heralded by the destruction of ecosystems and entire species.

…

Characterizing legitimate concerns about what kinds of technologies enter and help shape our world as “anti-science” is more likely to alienate than inspire “everyday Americans to identify with this vision of what science can do, and to believe in it.”

… perhaps we can make it productive in one way. Understanding the limitations of the process can help us think critically about how decision-making about synthetic biology going forward might be more open to a broader set of concerns and voices much earlier in the innovation process. The way forward is not drawing battle lines between those who are “for” or “against” science and closing down regulatory processes to all but the narrowest risk-based considerations. Rather, we should be forming and expanding spaces for a wide range of participants in creatively considering how to solve society’s biggest challenges. We need new ways of thinking and talking about technological promise and possibility in the world that we live in. [emphasis mine]

While Doersma is appealing to a US audience, her argument could be used internationally.

Final comments

Juma’s “Enemies of Innovation” and Keene’s “Science in Wonderland” are both worthwhile reads but it should be noted that Juma’s is the more ambitious. Keene is looking back and expanding the perspective in an area of previously mined children’s literature which hints at possible implications for our own time period..

For example, I think contemporary audiences might want to consider how much science, technology, and mathematics finds its way into our ‘fairy tales’ or super hero, space adventure, cartoons,, and other popular stories of today. Iron Man and his colleagues in one of the Avengers’ movies faced off with a robot/artificial intelligence entity, Ultron, suggesting potential existential risk; Star Trek’s impact on today’s technologies is widely acknowledged, and The Simpsons , a US animated programme, regularly embeds mathematics in its stories.

Juma examines history while attempting to extrapolate lessons for the future.It’s a courageous and worthwhile effort. While I’m not entirely comfortable with his top-down approach he knits together a comprehensive programme for policy makers and makes two point that I believe are too often overlooked, more agility is needed and these are global issues.

“Innovation and its enemies” and “Science in Wonderland”: a commentary on two books and a few thoughts about fish (1 of 2)

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There’s more than one way to approach the introduction of emerging technologies and sciences to ‘the public’. Calestous Juma in his 2016 book, ”Innovation and Its Enemies; Why People Resist New Technologies” takes a direct approach, as can be seen from the title while Melanie Keene’s 2015 book, “Science in Wonderland; The Scientific Fairy Tales of Victorian Britain” presents a more fantastical one. The fish in the headline tie together, thematically and tenuously, both books with a real life situation.

Innovation and Its Enemies

Calestous Juma, the author of “Innovation and Its Enemies” has impressive credentials,

Professor of the Practice of International Development,
Director of the Science, Technology, and Globalization Project at Harvard Kennedy School’s Better Science and International Affairs,
Founding Director of the African Centre for Technology Studies in Nairobi (Kenya),
Fellow of the Royal Society of London, and
Foreign Associate of the US National Academy of Sciences.

Even better, Juma is an excellent storyteller perhaps too much so for a book which presents a series of science and technology adoption case histories. (Given the range of historical time periods, geography, and the innovations themselves, he always has to stop short.) The breadth is breathtaking and Juma manages with aplomb. For example, the innovations covered include: coffee, electricity, mechanical refrigeration, margarine, recorded sound, farm mechanization, and the printing press. He also covers two recently emerging technologies/innovations: transgenic crops and AquAdvantage salmon (more about the salmon later).

Juma provides an analysis of the various ways in which the public and institutions panic over innovation and goes on to offer solutions. He also injects a subtle note of humour from time to time. Here’s how Juma describes various countries’ response to risks and benefits,

In the United States products are safe until proven risky.

In France products are risky until proven safe.

In the United Kingdom products are risky even when proven safe.

In India products are safe when proven risky.

In Canada products are neither safe nor risky.

In Japan products are either safe or risky.

In Brazil products are both safe and risky.

In sub-Saharan Africa products are risky even if they do not exist. (pp. 4-5)

To Calestous Juma, thank you for mentioning Canada and for so aptly describing the quintessentially Canadian approach to not just products and innovation but to life itself, ‘we just don’t know; it could be this or it could be that or it could be something entirely different; we just don’t know and probably will never know.’.

One of the aspects that I most appreciated in this book was the broadening of the geographical perspective on innovation and emerging technologies to include the Middle East, China, and other regions/countries. As I’ve noted in past postings, much of the discussion here in Canada is Eurocentric and/or UScentric. For example, the Council of Canadian Academies which conducts assessments of various science questions at the request of Canadian and regional governments routinely fills the ‘international’ slot(s) for their expert panels with academics from Europe (mostly Great Britain) and/or the US (or sometimes from Australia and/or New Zealand).

A good example of Juma’s expanded perspective on emerging technology is offered in Art Carden’s July 7, 2017 book review for Forbes.com (Note: A link has been removed),

In the chapter on coffee, Juma discusses how Middle Eastern and European societies resisted the beverage and, in particular, worked to shut down coffeehouses. Islamic jurists debated whether the kick from coffee is the same as intoxication and therefore something to be prohibited. Appealing to “the principle of original permissibility — al-ibaha, al-asliya — under which products were considered acceptable until expressly outlawed,” the fifteenth-century jurist Muhamad al-Dhabani issued several fatwas in support of keeping coffee legal.

This wasn’t the last word on coffee, which was banned and permitted and banned and permitted and banned and permitted in various places over time. Some rulers were skeptical of coffee because it was brewed and consumed in public coffeehouses — places where people could indulge in vices like gambling and tobacco use or perhaps exchange unorthodox ideas that were a threat to their power. It seems absurd in retrospect, but political control of all things coffee is no laughing matter.

The bans extended to Europe, where coffee threatened beverages like tea, wine, and beer. Predictably, and all in the name of public safety (of course!), European governments with the counsel of experts like brewers, vintners, and the British East India Tea Company regulated coffee importation and consumption. The list of affected interest groups is long, as is the list of meddlesome governments. Charles II of England would issue A Proclamation for the Suppression of Coffee Houses in 1675. Sweden prohibited coffee imports on five separate occasions between 1756 and 1817. In the late seventeenth century, France required that all coffee be imported through Marseilles so that it could be more easily monopolized and taxed.

Carden who teaches economics at Stanford University (California, US) focuses on issues of individual liberty and the rule of law with regards to innovation. I can appreciate the need to focus tightly when you have a limited word count but Carden could have a spared a few words to do more justice to Juma’s comprehensive and focused work.

At the risk of being accused of the fault I’ve attributed to Carden, I must mention the printing press chapter. While it was good to see a history of the printing press and attendant social upheavals noting its impact and discovery in regions other than Europe; it was shocking to someone educated in Canada to find Marshall McLuhan entirely ignored. Even now, I believe it’s virtually impossible to discuss the printing press as a technology, in Canada anyway, without mentioning our ‘communications god’ Marshall McLuhan and his 1962 book, The Gutenberg Galaxy.

Getting back to Juma’s book, his breadth and depth of knowledge, history, and geography is packaged in a relatively succinct 316 pp. As a writer, I admire his ability to distill the salient points and to devote chapters on two emerging technologies. It’s notoriously difficult to write about a currently emerging technology and Juma even managed to include a reference published only months (in early 2016) before “Innovation and its enemires” was published in July 2016.

Irrespective of Marshall McLuhan, I feel there are a few flaws. The book is intended for policy makers and industry (lobbyists, anyone?), he reaffirms (in academia, industry, government) a tendency toward a top-down approach to eliminating resistance. From Juma’s perspective, there needs to be better science education because no one who is properly informed should have any objections to an emerging/new technology. Juma never considers the possibility that resistance to a new technology might be a reasonable response. As well, while there was some mention of corporate resistance to new technologies which might threaten profits and revenue, Juma didn’t spare any comments about how corporate sovereignty and/or intellectual property issues are used to stifle innovation and quite successfully, by the way.

My concerns aside, testimony to the book’s worth is Carden’s review almost a year after publication. As well, Sir Peter Gluckman, Chief Science Advisor to the federal government of New Zealand, mentions Juma’s book in his January 16, 2017 talk, Science Advice in a Troubled World, for the Canadian Science Policy Centre.

Science in Wonderland

Melanie Keene’s 2015 book, “Science in Wonderland; The scientific fairy tales of Victorian Britain” provides an overview of the fashion for writing and reading scientific and mathematical fairy tales and, inadvertently, provides an overview of a public education programme,

A fairy queen (Victoria) sat on the throne of Victoria’s Britain, and she presided over a fairy tale age. The nineteenth century witnessed an unprecedented interest in fairies and in their tales, as they were used as an enchanted mirror in which to reflection question, and distort contemporary society.³⁰ … Fairies could be found disporting themselves thought the century on stage and page, in picture and print, from local haunts to global transports. There were myriad ways in which authors, painters, illustrators, advertisers, pantomime performers, singers, and more, capture this contemporary enthusiasm and engaged with fairyland and folklore; books, exhibitions, and images for children were one of the most significant. (p. 13)

…

… Anthropologists even made fairies the subject of scientific analysis, as ‘fairyology’ determined whether fairies should be part of natural history or part of supernatural lore; just on aspect of the revival of interest in folklore. Was there a tribe of fairy creatures somewhere out thee waiting to be discovered, across the globe of in the fossil record? Were fairies some kind of folks memory of any extinct race? (p. 14)

…

Scientific engagements with fairyland was widespread, and not just as an attractive means of packaging new facts for Victorian children.⁴² … The fairy tales of science had an important role to play in conceiving of new scientific disciplines; in celebrating new discoveries; in criticizing lofty ambitions; in inculcating habits of mind and body; in inspiring wonder; in positing future directions; and in the consideration of what the sciences were, and should be. A close reading of these tales provides a more sophisticated understanding of the content and status of the Victorian sciences; they give insights into what these new scientific disciplines were trying to do; how they were trying to cement a certain place in the world; and how they hoped to recruit and train new participants. (p. 18)

Segue: Should you be inclined to believe that society has moved on from fairies; it is possible to become a certified fairyologist (check out the fairyologist.com website).

“Science in Wonderland,” the title being a reference to Lewis Carroll’s Alice, was marketed quite differently than “innovation and its enemies”. There is no description of the author, as is the protocol in academic tomes, so here’s more from her webpage on the University of Cambridge (Homerton College) website,

Role:

Fellow, Graduate Tutor, Director of Studies for History and Philosophy of Science

Getting back to Keene’s book, she makes the point that the fairy tales were based on science and integrated scientific terminology in imaginative ways although some books with more success than other others. Topics ranged from paleontology, botany, and astronomy to microscopy and more.

This book provides a contrast to Juma’s direct focus on policy makers with its overview of the fairy narratives. Keene is primarily interested in children but her book casts a wider net “… they give insights into what these new scientific disciplines were trying to do; how they were trying to cement a certain place in the world; and how they hoped to recruit and train new participants.”

In a sense both authors are describing how technologies are introduced and integrated into society. Keene provides a view that must seem almost halcyon for many contemporary innovation enthusiasts. As her topic area is children’s literature any resistance she notes is primarily literary invoking a debate about whether or not science was killing imagination and whimsy.

It would probably help if you’d taken a course in children’s literature of the 19th century before reading Keene’s book is written . Even if you haven’t taken a course, it’s still quite accessible, although I was left wondering about ‘Alice in Wonderland’ and its relationship to mathematics (see Melanie Bayley’s December 16, 2009 story for the New Scientist for a detailed rundown).

As an added bonus, fairy tale illustrations are included throughout the book along with a section of higher quality reproductions.

One of the unexpected delights of Keene’s book was the section on L. Frank Baum and his electricity fairy tale, “The Master Key.” She stretches to include “The Wizard of Oz,” which doesn’t really fit but I can’t see how she could avoid mentioning Baum’s most famous creation. There’s also a surprising (to me) focus on water, which when it’s paired with the interest in microscopy makes sense. Keene isn’t the only one who has to stretch to make things fit into her narrative and so from water I move onto fish bringing me back to one of Juma’s emerging technologies

Part 2: Fish and final comments

May/June 2017 scienceish events in Canada (mostly in Vancouver)

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I have five* events for this posting

(1) Science and You (Montréal)

The latest iteration of the Science and You conference took place May 4 – 6, 2017 at McGill University (Montréal, Québec). That’s the sad news, the good news is that they have recorded and released the sessions onto YouTube. (This is the first time the conference has been held outside of Europe, in fact, it’s usually held in France.) Here’s why you might be interested (from the 2017 conference page),

The animator of the conference will be Véronique Morin:

Véronique Morin is science journalist and communicator, first president of the World Federation of Science Journalists (WFSJ) and serves as judge for science communication awards. She worked for a science program on Quebec’s public TV network, CBCRadio-Canada, TVOntario, and as a freelancer is also a contributor to -among others- The Canadian Medical Journal, University Affairs magazine, NewsDeeply, while pursuing documentary projects.

Let’s talk about S …

Holding the attention of an audience full of teenagers may seem impossible… particularly on topics that might be seen as boring, like sciences! Yet, it’s essential to demistify science in order to make it accessible, even appealing in the eyes of futur citizens.
How can we encourage young adults to ask themselves questions about the surrounding world, nature and science? How can we make them discover sciences with and without digital tools?

Find out tips and tricks used by our speakers Kristin Alford and Amanda Tyndall.

Kristin Alford
Dr Kristin Alford is a futurist and the inaugural Director of MOD., a futuristic museum of discovery at the University of South Australia. Her mind is presently occupied by the future of work and provoking young adults to ask questions about the role of science at the intersection of art and innovation.

Internet Website

Amanda Tyndall
Over 20 years of science communication experience with organisations such as Café Scientifique, The Royal Institution of Great Britain (and Australia’s Science Exchange), the Science Museum in London and now with the Edinburgh International Science Festival. Particularly interested in engaging new audiences through linkages with the arts and digital/creative industries.

Internet Website

A troll in the room

Increasingly used by politicians, social media can reach thousand of people in few seconds. Relayed to infinity, the message seems truthful, but is it really? At a time of fake news and alternative facts, how can we, as a communicator or a journalist, take up the challenge of disinformation?
Discover the traps and tricks of disinformation in the age of digital technologies with our two fact-checking experts, Shawn Otto and Vanessa Schipani, who will offer concrete solutions to unravel the true from the false..

Shawn Otto
Shawn Otto was awarded the IEEE-USA (“I-Triple-E”) National Distinguished Public Service Award for his work elevating science in America’s national public dialogue. He is cofounder and producer of the US presidential science debates at ScienceDebate.org. He is also an award-winning screenwriter and novelist, best known for writing and co-producing the Academy Award-nominated movie House of Sand and Fog.

Website

Vanessa Schipani
Vanessa is a science journalist at FactCheck.org, which monitors U.S. politicians’ claims for accuracy. Previously, she wrote for outlets in the U.S., Europe and Japan, covering topics from quantum mechanics to neuroscience. She has bachelor’s degrees in zoology and philosophy and a master’s in the history and philosophy of science.

Website

At 20,000 clicks from the extreme

Sharing living from a space station, ship or submarine. The examples of social media use in extreme conditions are multiplying and the public is asking for more. How to use public tools to highlight practices and discoveries? How to manage the use of social networks of a large organisation? What pitfalls to avoid? What does this mean for citizens and researchers?
Find out with Phillipe Archambault and Leslie Elliott experts in extrem conditions.

Philippe Archambault

Professor Philippe Archambault is a marine ecologist at Laval University, the director of the Notre Golfe network and president of the 4th World Conference on Marine Biodiversity. His research on the influence of global changes on biodiversity and the functioning of ecosystems has led him to work in all four corners of our oceans from the Arctic to the Antarctic, through Papua New Guinea and the French Polynesia.

Website

Leslie Elliott

Leslie Elliott leads a team of communicators at Ocean Networks Canada in Victoria, British Columbia, home to Canada’s world-leading ocean observatories in the Pacific and Arctic Oceans. Audiences can join robots equipped with high definition cameras via #livedive to discover more about our ocean.

Website

Science is not a joke!

Science and humor are two disciplines that might seem incompatible … and yet, like the ig-Nobels, humour can prove to be an excellent way to communicate a scientific message. This, however, can prove to be quite challenging since one needs to ensure they employ the right tone and language to both captivate the audience while simultaneously communicating complex topics.

Patrick Baud and Brian Malow, both well-renowned scientific communicators, will give you with the tools you need to capture your audience and also convey a proper scientific message. You will be surprised how, even in Science, a good dose of humour can make you laugh and think.

Patrick Baud
Patrick Baud is a French author who was born on June 30, 1979, in Avignon. He has been sharing for many years his passion for tales of fantasy, and the marvels and curiosities of the world, through different media: radio, web, novels, comic strips, conferences, and videos. His YouTube channel “Axolot”, was created in 2013, and now has over 420,000 followers.

Internet Website
Youtube

Brian Malow
Brian Malow is Earth’s Premier Science Comedian (self-proclaimed). Brian has made science videos for Time Magazine and contributed to Neil deGrasse Tyson’s radio show. He worked in science communications at a museum, blogged for Scientific American, and trains scientists to be better communicators.

Internet Website
YouTube

I don’t think they’ve managed to get everything up on YouTube yet but the material I’ve found has been subtitled (into French or English, depending on which language the speaker used).

Here are the opening day’s talks on YouTube with English subtitles or French subtitles when appropriate. You can also find some abstracts for the panel presentations here. I was particularly in this panel (S3 – The Importance of Reaching Out to Adults in Scientific Culture), Note: I have searched out the French language descriptions for those unavailable in English,

Organized by Coeur des sciences, Université du Québec à Montréal (UQAM)
Animator: Valérie Borde, Freelance Science Journalist

Anouk Gingras, Musée de la civilisation, Québec
Text not available in English

[La science au Musée de la civilisation c’est :
• Une cinquantaine d’expositions et espaces découvertes
• Des thèmes d’actualité, liés à des enjeux sociaux, pour des exposition souvent destinées aux adultes
• Un potentiel de nouveaux publics en lien avec les autres thématiques présentes au Musée (souvent non scientifiques)
L’exposition Nanotechnologies : l’invisible révolution :
• Un thème d’actualité suscitant une réflexion
• Un sujet sensible menant à la création d’un parcours d’exposition polarisé : choix entre « oui » ou « non » au développement des nanotechnologies pour l’avenir
• L’utilisation de divers éléments pour rapprocher le sujet du visiteur

Les nanotechnologies dans la science-fiction

Les objets du quotidien contenant des nanoparticules

Les objets anciens qui utilisant les nanotechnologies

Divers microscopes retraçant l’histoire des nanotechnologies

• Une forme d’interaction suscitant la réflexion du visiteur via un objet sympatique : le canard de plastique jaune, muni d’une puce RFID

Sept stations de consultation qui incitent le visiteur à se prononcer et à réfléchir sur des questions éthiques liées au développement des nanotechnologies

Une compilation des données en temps réel

Une livraison des résultats personnalisée

Une mesure des visiteurs dont l’opinion s’est modifiée à la suite de la visite de l’exposition

Résultats de fréquentation :
• Public de jeunes adultes rejoint (51%)
• Plus d’hommes que de femmes ont visité l’exposition
• Parcours avec canard: incite à la réflexion et augmente l’attention
• 3 visiteurs sur 4 prennent le canard; 92% font l’activité en entier]

Marie Lambert-Chan, Québec Science
Capting the attention of adult readership : challenging mission, possible mission
Since 1962, Québec Science Magazine is the only science magazine aimed at an adult readership in Québec. Our mission : covering topical subjects related to science and technology, as well as social issues from a scientific point of view. Each year, we print eight issues, with a circulation of 22,000 copies. Furthermore, the magazine has received several awards and accolades. In 2017, Québec Science Magazine was honored by the Canadian Magazine Awards/Grands Prix du Magazine and was named Best Magazine in Science, Business and Politics category.
Although we have maintained a solid reputation among scientists and the media industry, our magazine is still relatively unknown to the general public. Why is that ? How is it that, through all those years, we haven’t found the right angle to engage a broader readership ?
We are still searching for definitive answers, but here are our observations :
Speaking science to adults is much more challenging than it is with children, who can marvel endlessly at the smallest things. Unfortunately, adults lose this capacity to marvel and wonder for various reasons : they have specific interests, they failed high-school science, they don’t feel competent enough to understand scientific phenomena. How do we bring the wonder back ? This is our mission. Not impossible, and hopefully soon to be accomplished. One noticible example is the number of reknown scientists interviewed during the popular talk-show Tout le monde en parle, leading us to believe the general public may have an interest in science.
However, to accomplish our mission, we have to recount science. According to the Bulgarian writer and blogger Maria Popova, great science writing should explain, elucidate and enchant . To explain : to make the information clear and comprehensible. To elucidate : to reveal all the interconnections between the pieces of information. To enchant : to go beyond the scientific terms and information and tell a story, thus giving a kaleidoscopic vision of the subject. This is how we intend to capture our readership’s attention.
Our team aims to accomplish this challenge. Although, to be perfectly honest, it would be much easier if we had more resources, financial-wise or human-wise. However, we don’t lack ideas. We dream of major scientific investigations, conferences organized around themes from the magazine’s issues, Web documentaries, podcasts… Such initiatives would give us the visibility we desperately crave.
That said, even in the best conditions, would be have more subscribers ? Perhaps. But it isn’t assured. Even if our magazine is aimed at adult readership, we are convinced that childhood and science go hand in hand, and is even decisive for the children’s future. At the moment, school programs are not in place for continuous scientific development. It is possible to develop an interest for scientific culture as adults, but it is much easier to achieve this level of curiosity if it was previously fostered.

Robert Lamontagne, Université de Montréal
Since the beginning of my career as an astrophysicist, I have been interested in scientific communication to non-specialist audiences. I have presented hundreds of lectures describing the phenomena of the cosmos. Initially, these were mainly offered in amateur astronomers’ clubs or in high-schools and Cégeps. Over the last few years, I have migrated to more general adult audiences in the context of cultural activities such as the “Festival des Laurentides”, the Arts, Culture and Society activities in Repentigny and, the Université du troisième âge (UTA) or Senior’s University.
The Quebec branch of the UTA, sponsored by the Université de Sherbrooke (UdeS), exists since 1976. Seniors universities, created in Toulouse, France, are part of a worldwide movement. The UdeS and its senior’s university antennas are members of the International Association of the Universities of the Third Age (AIUTA). The UTA is made up of 28 antennas located in 10 regions and reaches more than 10,000 people per year. Antenna volunteers prepare educational programming by drawing on a catalog of courses, seminars and lectures, covering a diverse range of subjects ranging from history and politics to health, science, or the environment.
The UTA is aimed at people aged 50 and over who wish to continue their training and learn throughout their lives. It is an attentive, inquisitive, educated public and, given the demographics in Canada, its number is growing rapidly. This segment of the population is often well off and very involved in society.
I usually use a two-prong approach.
• While remaining rigorous, the content is articulated around a few ideas, avoiding analytical expressions in favor of a qualitative description.
• The narrative framework, the story, which allows to contextualize the scientific content and to forge links with the audience.

Sophie Malavoy, Coeur des sciences – UQAM

Many obstacles need to be overcome in order to reach out to adults, especially those who aren’t in principle interested in science.
• Competing against cultural activities such as theater, movies, etc.
• The idea that science is complex and dull
• A feeling of incompetence. « I’ve always been bad in math and physics»
• Funding shortfall for activities which target adults
How to reach out to those adults?
• To put science into perspective. To bring its relevance out by making links with current events and big issues (economic, heath, environment, politic). To promote a transdisciplinary approach which includes humanities and social sciences.
• To stake on originality by offering uncommon and ludic experiences (scientific walks in the city, street performances, etc.)
• To bridge between science and popular activities to the public (science/music; science/dance; science/theater; science/sports; science/gastronomy; science/literature)
• To reach people with emotions without sensationalism. To boost their curiosity and ability to wonder.
• To put a human face on science, by insisting not only on the results of a research but on its process. To share the adventure lived by researchers.
• To liven up people’s feeling of competence. To insist on the scientific method.
• To invite non-scientists (citizens groups, communities, consumers, etc.) to the reflections on science issues (debate, etc.). To move from dissemination of science to dialog

Didier Pourquery, The Conversation France
Text not available in English

[Depuis son lancement en septembre 2015 la plateforme The Conversation France (2 millions de pages vues par mois) n’a cessé de faire progresser son audience. Selon une étude menée un an après le lancement, la structure de lectorat était la suivante
Pour accrocher les adultes et les ainés deux axes sont intéressants ; nous les utilisons autant sur notre site que sur notre newsletter quotidienne – 26.000 abonnés- ou notre page Facebook (11500 suiveurs):
1/ expliquer l’actualité : donner les clefs pour comprendre les débats scientifiques qui animent la société ; mettre de la science dans les discussions (la mission du site est de « nourrir le débat citoyen avec de l’expertise universitaire et de la recherche »). L’idée est de poser des questions de compréhension simple au moment où elles apparaissent dans le débat (en période électorale par exemple : qu’est-ce que le populisme ? Expliqué par des chercheurs de Sciences Po incontestables.)
Exemples : comprendre les conférences climat -COP21, COP22 – ; comprendre les débats de société (Gestation pour autrui); comprendre l’économie (revenu universel); comprendre les maladies neurodégénératives (Alzheimer) etc.
2/ piquer la curiosité : utiliser les formules classiques (le saviez-vous ?) appliquées à des sujets surprenants (par exemple : « Que voit un chien quand il regarde la télé ? » a eu 96.000 pages vues) ; puis jouer avec ces articles sur les réseaux sociaux. Poser des questions simples et surprenantes. Par exemple : ressemblez-vous à votre prénom ? Cet article académique très sérieux a comptabilisé 95.000 pages vues en français et 171.000 en anglais.
3/ Susciter l’engagement : faire de la science participative simple et utile. Par exemple : appeler nos lecteurs à surveiller l’invasion de moustiques tigres partout sur le territoire. Cet article a eu 112.000 pages vues et a été republié largement sur d’autres sites. Autre exemple : appeler les lecteurs à photographier les punaises de leur environnement.]

Here are my very brief and very rough translations. (1) Anouk Gingras is focused largely on a nanotechnology exhibit and whether or not visitors went through it and participated in various activities. She doesn’t seem specifically focused on science communication for adults but they are doing some very interesting and related work at Québec’s Museum of Civilization. (2) Didier Pourquery is describing an online initiative known as ‘The Conversation France’ (strange—why not La conversation France?). Moving on, there’s a website with a daily newsletter (blog?) and a Facebook page. They have two main projects, one is a discussion of current science issues in society, which is informed with and by experts but is not exclusive to experts, and more curiosity-based science questions and discussion such as What does a dog see when it watches television?

Serendipity! I hadn’t stumbled across this conference when I posted my May 12, 2017 piece on the ‘insanity’ of science outreach in Canada. It’s good to see I’m not the only one focused on science outreach for adults and that there is some action, although seems to be a Québec-only effort.

(2) Ingenious—a book launch in Vancouver

The book will be launched on Thursday, June 1, 2017 at the Vancouver Public Library’s Central Branch (from the Ingenious: An Evening of Canadian Innovation event page)

Ingenious: An Evening of Canadian Innovation
Thursday, June 1, 2017 (6:30 pm – 8:00 pm)
Central Branch
Description

Gov. Gen. David Johnston and OpenText Corp. chair Tom Jenkins discuss Canadian innovation and their book Ingenious: How Canadian Innovators Made the World Smarter, Smaller, Kinder, Safer, Healthier, Wealthier and Happier.

Books will be available for purchase and signing.

Doors open at 6 p.m.

INGENIOUS : HOW CANADIAN INNOVATORS MADE THE WORLD SMARTER, SMALLER, KINDER, SAFER, HEALTHIER, WEALTHIER, AND HAPPIER

Address:

350 West Georgia St.
VancouverV6B 6B1

Get Directions

Phone: (604) 331-3603

Location Details:

Alice MacKay Room, Lower Level

I do have a few more details about the authors and their book. First, there’s this from the Ottawa Writer’s Festival March 28, 2017 event page,

To celebrate Canada’s 150th birthday, Governor General David Johnston and Tom Jenkins have crafted a richly illustrated volume of brilliant Canadian innovations whose widespread adoption has made the world a better place. From Bovril to BlackBerrys, lightbulbs to liquid helium, peanut butter to Pablum, this is a surprising and incredibly varied collection to make Canadians proud, and to our unique entrepreneurial spirit.

Successful innovation is always inspired by at least one of three forces — insight, necessity, and simple luck. Ingenious moves through history to explore what circumstances, incidents, coincidences, and collaborations motivated each great Canadian idea, and what twist of fate then brought that idea into public acceptance. Above all, the book explores what goes on in the mind of an innovator, and maps the incredible spectrum of personalities that have struggled to improve the lot of their neighbours, their fellow citizens, and their species.

From the marvels of aboriginal invention such as the canoe, snowshoe, igloo, dogsled, lifejacket, and bunk bed to the latest pioneering advances in medicine, education, philanthropy, science, engineering, community development, business, the arts, and the media, Canadians have improvised and collaborated their way to international admiration. …

Then, there’s this April 5, 2017 item on Canadian Broadcasting Corporation’s (CBC) news online,

From peanut butter to the electric wheelchair, the stories behind numerous life-changing Canadian innovations are detailed in a new book.

Gov. Gen. David Johnston and Tom Jenkins, chair of the National Research Council and former CEO of OpenText, are the authors of Ingenious: How Canadian Innovators Made the World Smarter, Smaller, Kinder, Safer, Healthier, Wealthier and Happier. The authors hope their book reinforces and extends the culture of innovation in Canada.

Test your knowledge of these life-changing Canadian inventions

“We started wanting to tell 50 stories of Canadian innovators, and what has amazed Tom and myself is how many there are,” Johnston told The Homestretch on Wednesday. The duo ultimately chronicled 297 innovations in the book, including the pacemaker, life jacket and chocolate bars.

“Innovations are not just technological, not just business, but they’re social innovations as well,” Johnston said.

Many of those innovations, and the stories behind them, are not well known.

“We’re sort of a humble people,” Jenkins said. “We’re pretty quiet. We don’t brag, we don’t talk about ourselves very much, and so we then lead ourselves to believe as a culture that we’re not really good inventors, the Americans are. And yet we knew that Canadians were actually great inventors and innovators.”

‘Opportunities and challenges’

For Johnston, his favourite story in the book is on the light bulb.

“It’s such a symbol of both our opportunities and challenges,” he said. “The light bulb was invented in Canada, not the United States. It was two inventors back in the 1870s that realized that if you passed an electric current through a resistant metal it would glow, and they patented that, but then they didn’t have the money to commercialize it.”

American inventor Thomas Edison went on to purchase that patent and made changes to the original design.

Johnston and Jenkins are also inviting readers to share their own innovation stories, on the book’s website.

I’m looking forward to the talk and wondering if they’ve included the botox and cellulose nanocrystal (CNC) stories to the book. BTW, Tom Jenkins was the chair of a panel examining Canadian research and development and lead author of the panel’s report (Innovation Canada: A Call to Action) for the then Conservative government (it’s also known as the Jenkins report). You can find out more about in my Oct. 21, 2011 posting.

(3) Made in Canada (Vancouver)

This is either fortuitous or there’s some very high level planning involved in the ‘Made in Canada; Inspiring Creativity and Innovation’ show which runs from April 21 – Sept. 4, 2017 at Vancouver’s Science World (also known as the Telus World of Science). From the Made in Canada; Inspiring Creativity and Innovation exhibition page,

Celebrate Canadian creativity and innovation, with Science World’s original exhibition, Made in Canada, presented by YVR [Vancouver International Airport] — where you drive the creative process! Get hands-on and build the fastest bobsled, construct a stunning piece of Vancouver architecture and create your own Canadian sound mashup, to share with friends.

Vote for your favourite Canadian inventions and test fly a plane of your design. Discover famous (and not-so-famous, but super neat) Canadian inventions. Learn about amazing, local innovations like robots that teach themselves, one-person electric cars and a computer that uses parallel universes.

Imagine what you can create here, eh!!

You can find more information here.

One quick question, why would Vancouver International Airport be presenting this show? I asked that question of Science World’s Communications Coordinator, Jason Bosher, and received this response,

YVR is the presenting sponsor. They donated money to the exhibition and they also contributed an exhibit for the “We Move” themed zone in the Made in Canada exhibition. The YVR exhibit details the history of the YVR airport, it’s geographic advantage and some of the planes they have seen there.

I also asked if there was any connection between this show and the ‘Ingenious’ book launch,

Some folks here are aware of the book launch. It has to do with the Canada 150 initiative and nothing to do with the Made in Canada exhibition, which was developed here at Science World. It is our own original exhibition.

So there you have it.

(4) Robotics, AI, and the future of work (Ottawa)

I’m glad to finally stumble across a Canadian event focusing on the topic of artificial intelligence (AI), robotics and the future of work. Sadly (for me), this is taking place in Ottawa. Here are more details from the May 25, 2017 notice (received via email) from the Canadian Science Policy Centre (CSPC),

CSPC is Partnering with CIFAR {Canadian Institute for Advanced Research]
The Second Annual David Dodge Lecture
…
Join CIFAR and Senior Fellow Daron Acemoglu for
the Second Annual David Dodge CIFAR Lecture in Ottawa on June 13.
June 13, 2017 | 12 – 2 PM [emphasis mine]
Fairmont Château Laurier, Drawing Room | 1 Rideau St, Ottawa, ON
Along with the backlash against globalization and the outsourcing of jobs, concern is also growing about the effect that robotics and artificial intelligence will have on the labour force in advanced industrial nations. World-renowned economist Acemoglu, author of the best-selling book Why Nations Fail, will discuss how technology is changing the face of work and the composition of labour markets. Drawing on decades of data, Acemoglu explores the effects of widespread automation on manufacturing jobs, the changes we can expect from artificial intelligence technologies, and what responses to these changes might look like. This timely discussion will provide valuable insights for current and future leaders across government, civil society, and the private sector.

Daron Acemoglu is a Senior Fellow in CIFAR’s Insitutions, Organizations & Growth program, and the Elizabeth and James Killian Professor of Economics at the Massachusetts Institute of Technology.

Tickets: $15 (A light lunch will be served.)

You can find a registration link here. Also, if you’re interested in the Canadian efforts in the field of artificial intelligence you can find more in my March 24, 2017 posting (scroll down about 25% of the way and then about 40% of the way) on the 2017 Canadian federal budget and science where I first noted the $93.7M allocated to CIFAR for launching a Pan-Canadian Artificial Intelligence Strategy.

(5) June 2017 edition of the Curiosity Collider Café (Vancouver)

This is an art/science (also known called art/sci and SciArt) that has taken place in Vancouver every few months since April 2015. Here’s more about the June 2017 edition (from the Curiosity Collider events page),

Collider Cafe

When
8:00pm on Wednesday, June 21st, 2017. Door opens at 7:30pm.

Where
Café Deux Soleils. 2096 Commercial Drive, Vancouver, BC (Google Map).

Cost
$5.00-10.00 cover at the door (sliding scale). Proceeds will be used to cover the cost of running this event, and to fund future Curiosity Collider events. Curiosity Collider is a registered BC non-profit organization.

***

#ColliderCafe is a space for artists, scientists, makers, and anyone interested in art+science. Meet, discover, connect, create. How do you explore curiosity in your life? Join us and discover how our speakers explore their own curiosity at the intersection of art & science.

Ela Kurowska (photographer and biochemist)

Dave Ng (geneticist, science literacy academic, and faculty at UBC)

Wesley Raley (candymaker at Wishing Treats, food industry consultant)

Germana Barata (science communication researcher)

Vincent van Haaff (multimedia artist)

The event will start promptly at 8pm (doors open at 7:30pm). $5.00-10.00 (sliding scale) cover at the door. Proceeds will be used to cover the cost of running this event, and to fund future Curiosity Collider events. Curiosity Collider is a registered BC non-profit organization.

Enjoy!

*I changed ‘three’ events to ‘five’ events and added a number to each event for greater reading ease on May 31, 2017.

Inaugural Italian Scientists and Scholars of North America Foundation (ISSNAF) annual meeting

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Thanks to a May 17, 2017 announcement I received via email from the ArtSci Salon, I’ve learned of a rather intriguing annual meeting to be held May 19-20, 2017 in Toronto, Ontario,

We are pleased to invite you to attend the Italian Scientists and
Scholars of North America Foundation (ISSNAF) inaugural annual
conference in Canada, which will be held on May 19-20th, 2017 at the
Istituto Italiano di Cultura, Toronto, Ontario.

During the event, the Italian scientific community will meet the
institutions, the industry, academia to discuss breakthrough ideas, to
network, and to award projects of young Italians through the ISSNAF
Young Investigators Awards.

The event is organized under the auspices of H.E. Ambassador CLAUDIO
TAFFURI, Consul General of Italy in Toronto, GIUSEPPE PASTORELLI,
Director of the Istituto Italiano di Cultura in Toronto, ALESSANDRO
RUGGERA and Scientific Attaché of the Italian Embassy in Ottawa, ANNA
GALLUCCIO. This year’s exciting conference will focus on innovation,
exploring innovation as invention and transformation, as well as its
impact on how we live and think.

After an introduction by H.E. Ambassador of Italy, CLAUDIO TAFFURI,
and other representatives of Italian institutions, the event will open
with two prominent speakers: PAOLO MACCARIO, Chief Operating Officer
and General Manager at Silfab Ontario Inc. and FRANCO VACCARINO,
President and Vice-Chancellor of Guelph University, who will discuss
current and future strategies in academia and industry required for
students and workers to deal with the disruptive technologies and the
exponential increase in knowledge.

The later part of the day will feature speakers from different
institutions from all over Canada. CORRADO PAINA, President of the
Italian Chamber of Commerce, will address the importance of innovation
and research from the industry prospective. UMBERTO BERARDI, Associate
Professor, Faculty of Engineering and Architecture, Ryerson
University, will bring his experience as winner of the Franco
Strazzabosco Award for Engineers. Nicola Fameli, Research Associate of
Anesthesiology, Pharmacology and Therapeutics, U. of British Columbia
and Franco Mammarella, Group leader [TRIUMF] Canada’s National Laboratory for
Particle and Nuclear Physics, president and vice-president of ARPICO
(Society of Italian Researchers & Professionals in Western Canada),
will explain the importance of developing a global network amongst
researchers. The day will be closed by GABRIELLA GOBBI, Associate
Professor, Dept. Psychiatry, McGill University on the current status
of the Italian Scientific Community in Quebec.

Day One of ISSNAF’s Annual event will conclude with a reception at the
Istituto. Day Two of the event is dedicated to young Italian
researchers and scientists who will present their work and will
receive the ISSNAF Certificate for Young Investigators. The day will
end with a round table and a discussion directed by the ISSNAF Ontario
chapter Chairs, BARBARA CIFRA, VITO MENNELLA AND LEONARDO SALMENA on
how to build a successful academic network and how ISSNAF can
contribute to the process.

The event is limited to 50 people only [emphasis mine]. Please confirm your presence
by May 17th [2017] by sending an email to: iictoronto@esteri.it

Sorry to be posting this so late in the day (fingers crossed it’s not too late).

I did do some searching and found this description of the event on the ARPICO website,

On May 19-20th SIRO (Society of Italian researcher in Ontario) official Chapter of the Italian Scientists and Scholars of North America Foundation (ISSNAF) will host in cooperation with the Embassy of Italy in Ottawa the inaugural Canadian Annual ISSNAF meeting.

The event is organized under the auspices of H.E. Ambassador Claudio Taffuri, Consul General of Italy in Toronto, Giuseppe Pastorelli, and Director of the Istituto Italiano di Cultura in Toronto, Alessandro Ruggera and Scientific Attache’ of the Italian Embassy in Ottawa, Anna Galluccio. This year’s exciting conference will focus on innovation, exploring innovation as invention and transformation and its impact on how we live and think.

During the event, the italian scientific community meets the institutions, the industry, academia to discuss breakthrough ideas, to network, and to award projects of young Italians through the ISSNAF Young Investigators Awards.

…

For this year the event will be attended by 60 selected researchers and scholars working in Canada. [emphasis mine]

For more information email issnafontario@gmail.com

Good luck at getting to attend the event whether there are 50 or 60 participants.

Vector Institute and Canada’s artificial intelligence sector

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On the heels of the March 22, 2017 federal budget announcement of $125M for a Pan-Canadian Artificial Intelligence Strategy, the University of Toronto (U of T) has announced the inception of the Vector Institute for Artificial Intelligence in a March 28, 2017 news release by Jennifer Robinson (Note: Links have been removed),

A team of globally renowned researchers at the University of Toronto is driving the planning of a new institute staking Toronto’s and Canada’s claim as the global leader in AI.

Geoffrey Hinton, a University Professor Emeritus in computer science at U of T and vice-president engineering fellow at Google, will serve as the chief scientific adviser of the newly created Vector Institute based in downtown Toronto.

“The University of Toronto has long been considered a global leader in artificial intelligence research,” said U of T President Meric Gertler. “It’s wonderful to see that expertise act as an anchor to bring together researchers, government and private sector actors through the Vector Institute, enabling them to aim even higher in leading advancements in this fast-growing, critical field.”

As part of the Government of Canada’s Pan-Canadian Artificial Intelligence Strategy, Vector will share $125 million in federal funding with fellow institutes in Montreal and Edmonton. All three will conduct research and secure talent to cement Canada’s position as a world leader in AI.

In addition, Vector is expected to receive funding from the Province of Ontario and more than 30 top Canadian and global companies eager to tap this pool of talent to grow their businesses. The institute will also work closely with other Ontario universities with AI talent.

(See my March 24, 2017 posting; scroll down about 25% for the science part, including the Pan-Canadian Artificial Intelligence Strategy of the budget.)

Not obvious in last week’s coverage of the Pan-Canadian Artificial Intelligence Strategy is that the much lauded Hinton has been living in the US and working for Google. These latest announcements (Pan-Canadian AI Strategy and Vector Institute) mean that he’s moving back.

A March 28, 2017 article by Kate Allen for TorontoStar.com provides more details about the Vector Institute, Hinton, and the Canadian ‘brain drain’ as it applies to artificial intelligence, (Note: A link has been removed)

Toronto will host a new institute devoted to artificial intelligence, a major gambit to bolster a field of research pioneered in Canada but consistently drained of talent by major U.S. technology companies like Google, Facebook and Microsoft.

The Vector Institute, an independent non-profit affiliated with the University of Toronto, will hire about 25 new faculty and research scientists. It will be backed by more than $150 million in public and corporate funding in an unusual hybridization of pure research and business-minded commercial goals.

The province will spend $50 million over five years, while the federal government, which announced a $125-million Pan-Canadian Artificial Intelligence Strategy in last week’s budget, is providing at least $40 million, backers say. More than two dozen companies have committed millions more over 10 years, including $5 million each from sponsors including Google, Air Canada, Loblaws, and Canada’s five biggest banks [Bank of Montreal (BMO). Canadian Imperial Bank of Commerce ({CIBC} President’s Choice Financial}, Royal Bank of Canada (RBC), Scotiabank (Tangerine), Toronto-Dominion Bank (TD Canada Trust)].

The mode of artificial intelligence that the Vector Institute will focus on, deep learning, has seen remarkable results in recent years, particularly in image and speech recognition. Geoffrey Hinton, considered the “godfather” of deep learning for the breakthroughs he made while a professor at U of T, has worked for Google since 2013 in California and Toronto.

Hinton will move back to Canada to lead a research team based at the tech giant’s Toronto offices and act as chief scientific adviser of the new institute.

…

Researchers trained in Canadian artificial intelligence labs fill the ranks of major technology companies, working on tools like instant language translation, facial recognition, and recommendation services. Academic institutions and startups in Toronto, Waterloo, Montreal and Edmonton boast leaders in the field, but other researchers have left for U.S. universities and corporate labs.

The goals of the Vector Institute are to retain, repatriate and attract AI talent, to create more trained experts, and to feed that expertise into existing Canadian companies and startups.

…

Hospitals are expected to be a major partner, since health care is an intriguing application for AI. Last month, researchers from Stanford University announced they had trained a deep learning algorithm to identify potentially cancerous skin lesions with accuracy comparable to human dermatologists. The Toronto company Deep Genomics is using deep learning to read genomes and identify mutations that may lead to disease, among other things.

Intelligent algorithms can also be applied to tasks that might seem less virtuous, like reading private data to better target advertising. Zemel [Richard Zemel, the institute’s research director and a professor of computer science at U of T] says the centre is creating an ethics working group [emphasis mine] and maintaining ties with organizations that promote fairness and transparency in machine learning. As for privacy concerns, “that’s something we are well aware of. We don’t have a well-formed policy yet but we will fairly soon.”

The institute’s annual funding pales in comparison to the revenues of the American tech giants, which are measured in tens of billions. The risk the institute’s backers are taking is simply creating an even more robust machine learning PhD mill for the U.S.

“They obviously won’t all stay in Canada, but Toronto industry is very keen to get them,” Hinton said. “I think Trump might help there.” Two researchers on Hinton’s new Toronto-based team are Iranian, one of the countries targeted by U.S. President Donald Trump’s travel bans.

Ethics do seem to be a bit of an afterthought. Presumably the Vector Institute’s ‘ethics working group’ won’t include any regular folks. Is there any thought to what the rest of us think about these developments? As there will also be some collaboration with other proposed AI institutes including ones at the University of Montreal (Université de Montréal) and the University of Alberta (Kate McGillivray’s article coming up shortly mentions them), might the ethics group be centered in either Edmonton or Montreal? Interestingly, two Canadians (Timothy Caulfield at the University of Alberta and Eric Racine at Université de Montréa) testified at the US Commission for the Study of Bioethical Issues Feb. 10 – 11, 2014 meeting, the Brain research, ethics, and nanotechnology. Still speculating here but I imagine Caulfield and/or Racine could be persuaded to extend their expertise in ethics and the human brain to AI and its neural networks.

Getting back to the topic at hand the ‘AI sceneCanada’, Allen’s article is worth reading in its entirety if you have the time.

Kate McGillivray’s March 29, 2017 article for the Canadian Broadcasting Corporation’s (CBC) news online provides more details about the Canadian AI situation and the new strategies,

With artificial intelligence set to transform our world, a new institute is putting Toronto to the front of the line to lead the charge.

The Vector Institute for Artificial Intelligence, made possible by funding from the federal government revealed in the 2017 budget, will move into new digs in the MaRS Discovery District by the end of the year.

…

Vector’s funding comes partially from a $125 million investment announced in last Wednesday’s federal budget to launch a pan-Canadian artificial intelligence strategy, with similar institutes being established in Montreal and Edmonton.

“[A.I.] cuts across pretty well every sector of the economy,” said Dr. Alan Bernstein, CEO and president of the Canadian Institute for Advanced Research, the organization tasked with administering the federal program.

“Silicon Valley and England and other places really jumped on it, so we kind of lost the lead a little bit. I think the Canadian federal government has now realized that,” he said.

Stopping up the brain drain

Critical to the strategy’s success is building a homegrown base of A.I. experts and innovators — a problem in the last decade, despite pioneering work on so-called “Deep Learning” by Canadian scholars such as Yoshua Bengio and Geoffrey Hinton, a former University of Toronto professor who will now serve as Vector’s chief scientific advisor.

With few university faculty positions in Canada and with many innovative companies headquartered elsewhere, it has been tough to keep the few graduates specializing in A.I. in town.

“We were paying to educate people and shipping them south,” explained Ed Clark, chair of the Vector Institute and business advisor to Ontario Premier Kathleen Wynne.

…

The existence of that “fantastic science” will lean heavily on how much buy-in Vector and Canada’s other two A.I. centres get.

Toronto’s portion of the $125 million is a “great start,” said Bernstein, but taken alone, “it’s not enough money.”

“My estimate of the right amount of money to make a difference is a half a billion or so, and I think we will get there,” he said.

Jessica Murphy’s March 29, 2017 article for the British Broadcasting Corporation’s (BBC) news online offers some intriguing detail about the Canadian AI scene,

Canadian researchers have been behind some recent major breakthroughs in artificial intelligence. Now, the country is betting on becoming a big player in one of the hottest fields in technology, with help from the likes of Google and RBC [Royal Bank of Canada].

In an unassuming building on the University of Toronto’s downtown campus, Geoff Hinton laboured for years on the “lunatic fringe” of academia and artificial intelligence, pursuing research in an area of AI called neural networks.

Also known as “deep learning”, neural networks are computer programs that learn in similar way to human brains. The field showed early promise in the 1980s, but the tech sector turned its attention to other AI methods after that promise seemed slow to develop.

“The approaches that I thought were silly were in the ascendancy and the approach that I thought was the right approach was regarded as silly,” says the British-born [emphasis mine] professor, who splits his time between the university and Google, where he is a vice-president of engineering fellow.

…

Neural networks are used by the likes of Netflix to recommend what you should binge watch and smartphones with voice assistance tools. Google DeepMind’s AlphaGo AI used them to win against a human in the ancient game of Go in 2016.

…

Foteini Agrafioti, who heads up the new RBC Research in Machine Learning lab at the University of Toronto, said those recent innovations made AI attractive to researchers and the tech industry.

“Anything that’s powering Google’s engines right now is powered by deep learning,” she says.

Developments in the field helped jumpstart innovation and paved the way for the technology’s commercialisation. They also captured the attention of Google, IBM and Microsoft, and kicked off a hiring race in the field.

The renewed focus on neural networks has boosted the careers of early Canadian AI machine learning pioneers like Hinton, the University of Montreal’s Yoshua Bengio, and University of Alberta’s Richard Sutton.

Money from big tech is coming north, along with investments by domestic corporations like banking multinational RBC and auto parts giant Magna, and millions of dollars in government funding.

…

Former banking executive Ed Clark will head the institute, and says the goal is to make Toronto, which has the largest concentration of AI-related industries in Canada, one of the top five places in the world for AI innovation and business.

The founders also want it to serve as a magnet and retention tool for top talent aggressively head-hunted by US firms.

Clark says they want to “wake up” Canadian industry to the possibilities of AI, which is expected to have a massive impact on fields like healthcare, banking, manufacturing and transportation.

…

Google invested C$4.5m (US$3.4m/£2.7m) last November [2016] in the University of Montreal’s Montreal Institute for Learning Algorithms.

Microsoft is funding a Montreal startup, Element AI. The Seattle-based company also announced it would acquire Montreal-based Maluuba and help fund AI research at the University of Montreal and McGill University.

Thomson Reuters and General Motors both recently moved AI labs to Toronto.

…

RBC is also investing in the future of AI in Canada, including opening a machine learning lab headed by Agrafioti, co-funding a program to bring global AI talent and entrepreneurs to Toronto, and collaborating with Sutton and the University of Alberta’s Machine Intelligence Institute.

…

Canadian tech also sees the travel uncertainty created by the Trump administration in the US as making Canada more attractive to foreign talent. (One of Clark’s the selling points is that Toronto as an “open and diverse” city).

…

This may reverse the ‘brain drain’ but it appears Canada’s role as a ‘branch plant economy’ for foreign (usually US) companies could become an important discussion once more. From the ‘Foreign ownership of companies of Canada’ Wikipedia entry (Note: Links have been removed),

Historically, foreign ownership was a political issue in Canada in the late 1960s and early 1970s, when it was believed by some that U.S. investment had reached new heights (though its levels had actually remained stable for decades), and then in the 1980s, during debates over the Free Trade Agreement.

But the situation has changed, since in the interim period Canada itself became a major investor and owner of foreign corporations. Since the 1980s, Canada’s levels of investment and ownership in foreign companies have been larger than foreign investment and ownership in Canada. In some smaller countries, such as Montenegro, Canadian investment is sizable enough to make up a major portion of the economy. In Northern Ireland, for example, Canada is the largest foreign investor. By becoming foreign owners themselves, Canadians have become far less politically concerned about investment within Canada.

Of note is that Canada’s largest companies by value, and largest employers, tend to be foreign-owned in a way that is more typical of a developing nation than a G8 member. The best example is the automotive sector, one of Canada’s most important industries. It is dominated by American, German, and Japanese giants. Although this situation is not unique to Canada in the global context, it is unique among G-8 nations, and many other relatively small nations also have national automotive companies.

It’s interesting to note that sometimes Canadian companies are the big investors but that doesn’t change our basic position. And, as I’ve noted in other postings (including the March 24, 2017 posting), these government investments in science and technology won’t necessarily lead to a move away from our ‘branch plant economy’ towards an innovative Canada.

You can find out more about the Vector Institute for Artificial Intelligence here.

BTW, I noted that reference to Hinton as ‘British-born’ in the BBC article. He was educated in the UK and subsidized by UK taxpayers (from his Wikipedia entry; Note: Links have been removed),

Hinton was educated at King’s College, Cambridge graduating in 1970, with a Bachelor of Arts in experimental psychology.[1] He continued his study at the University of Edinburgh where he was awarded a PhD in artificial intelligence in 1977 for research supervised by H. Christopher Longuet-Higgins.[3][12]

It seems Canadians are not the only ones to experience ‘brain drains’.

Finally, I wrote at length about a recent initiative taking place between the University of British Columbia (Vancouver, Canada) and the University of Washington (Seattle, Washington), the Cascadia Urban Analytics Cooperative in a Feb. 28, 2017 posting noting that the initiative is being funded by Microsoft to the tune $1M and is part of a larger cooperative effort between the province of British Columbia and the state of Washington. Artificial intelligence is not the only area where US technology companies are hedging their bets (against Trump’s administration which seems determined to terrify people from crossing US borders) by investing in Canada.

For anyone interested in a little more information about AI in the US and China, there’s today’s (March 31, 2017)earlier posting: China, US, and the race for artificial intelligence research domination.

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Commentary about nanotech, science policy and communication, society, and the arts

Category Archives: innovation

Artificial intelligence (AI) brings together International Telecommunications Union (ITU) and World Health Organization (WHO) and AI outperforms animal testing

Leveraging the power of AI for health

Chemical testing without animals

How well does the computer identify toxic chemicals?

2018 Canadian Science Policy Conference (Nov. 7 – 9, 2018) highlights and Council of Canadian Academies: a communications job, a report, and more

2018 Canadian Science Policy Conference

Council of Canadian Academies: job and the ‘managing innovation’ report

Improving Innovation Through Better Management

AI (artificial intelligence) for Good Global Summit from May 15 – 17, 2018 in Geneva, Switzerland: details and an interview with Frederic Werner

The news

The interview

Finally

“Innovation and its enemies” and “Science in Wonderland”: a commentary on two books and a few thoughts about fish (2 of 2)

“Innovation and its enemies” and “Science in Wonderland”: a commentary on two books and a few thoughts about fish (1 of 2)

May/June 2017 scienceish events in Canada (mostly in Vancouver)

Location Details:

‘Opportunities and challenges’

Collider Cafe

Inaugural Italian Scientists and Scholars of North America Foundation (ISSNAF) annual meeting

Vector Institute and Canada’s artificial intelligence sector