Monthly Archives: February 2022

Use Gene Editing to Make Better Babies (a February 17, 2022 livestreamed debate from 05:00 PM − 06:30 PM EST)

I have high hopes for this debate on gene edited babies. Intelligence Squared US convenes good debates. (I watched their ‘de-extinction’ debate back in 2019, which coincidentally, featured George Church, one of the debaters in this event.) Not ‘good’ in that I necessarily agree or am interested in the topics but good as in thoughtful. Here’s more from the organization’s mission on their What is IQ2US? webpage,

A nonpartisan, nonprofit organization, Intelligence Squared U.S. addresses a fundamental problem in America: the extreme polarization of our nation and our politics.

Our mission is to restore critical thinking, facts, reason, and civility to American public discourse.

More about the upcoming debate can be found on the Use Gene Editing to Make Better Babies event page,

Use Gene Editing to Make Better Babies
Hosted By John Donvan

Thursday, February 17, 2022
05:00 PM − 06:30 PM EST

A genetic disease runs in your family. Your doctor tells you that, should you wish to have a child, that child is likely to also carry the disease. But a new gene-editing technology could change your fate. It could ensure that your baby is — and remains — healthy. Even more, it could potentially make sure your grandchildren are also free of the disease. What do you do? Now, imagine it’s not a rare genetic disorder, but general illness, or eye color, or cognitive ability, or athleticism. Do you opt into this new world of genetically edited humans? And what if it’s not just you. What your friends, neighbors, and colleagues are also embracing this genetic revolution? Right now, science doesn’t give you that choice. But huge advancements in CRISPR [clustered regularly interspaced short palindromic repeats] technology are making human gene editing a reality. In fact, in 2018, a Chinese scientist announced the first genetically modified babies; twin girls made to resist HIV, smallpox, and malaria. The promise of this technology is clear. But gene editing is not without its perils. Its critics say the technology is destined to exacerbate inequality, pressure all parents (and nations) into editing their children to stay competitive, and meddling with the most basic aspect of our humanity. In this context, we ask the question: Should we use gene editing to make better babies?

Main Points

The use of gene editing allows for couples to have children when they might otherwise have that option unavailable for them. It also allows for less to be left to chance during the pregnancy.

Gene editing will allow for babies to be born with reduced or eliminated chances of inheriting and passing on genes linked to diseases. We have a moral imperative to use technology that will improve the quality of life.

It is only a matter of time before gene editing becomes a widespread technology, potentially used by competitors and rivals on the international stage. If we have the technology, we should use it to our advantage to remain competitive.

The use of gene editing to create “better” outcomes in children will inherently create social stratification based on any gene editing, likely reflecting existing socioeconomic status. Additionally, the term ‘better’ is arbitrary and potentially short-sighted and dangerous.

Currently, there exist reasonable alternatives to gene editing for every condition for which gene editing can be used. 

The technology is still developing, and the long-term effects of any gene-editing could be potentially dangerous with consequences echoing throughout the gene environment. 

A February 8, 2022 Intelligence Squared U.S. news release about the upcoming debate (received via email) provides details about the debaters,

FOR THE MOTION – BIOS

* George Church, Geneticist & Founder, Personal Genome Project 
George Church is one of the nation’s leading geneticists and scholars. He is a professor of genetics at Harvard Medical School and MIT. In 1984, he developed the first direct genomic sequencing method, which resulted in the first genome sequence. He also helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. Church also serves as the director of the National Institutes of Health Center of Excellence in Genomic Science.  

* Amy Webb, Futurist & Author, “The Genesis Machine”  
Amy Webb is an award-winning author and futurist. She is the founder and CEO of the Future Today Institute and was named one of five women changing the world by Forbes. Her new book, “The Genesis Machine,” explores the future of synthetic biology, including human gene editing. Webb is a professor of strategic foresight at New York University’s Stern School of Business and has been elected a life member of the Council on Foreign Relations.  

AGAINST THE MOTION – BIOS

* Marcy Darnovsky, Policy Advocate & Executive Director, Center for Genetics and Society 
Marcy Darnovsky is a policy advocate and one of the most prominent voices on the politics of human biotechnology. As executive director of the Center for Genetics and Society, Darnovsky is focused on the social justice and public interest implications of gene editing. This work is informed by her background as an organizer and advocate in a range of environmental and progressive political movements.    

* Françoise Baylis, Philosopher & Author, “Altered Inheritance”  
Françoise Baylis is a philosopher whose innovative work in bioethics, at the intersection of policy and practice, has stretched the very boundaries of the field. She is the author of “Altered Inheritance: CRISPR and the Ethics of Human Genome Editing,” which explores the scientific, ethical, and political implications of human genome editing. Baylis is a research professor at Dalhousie University and a fellow of the Canadian Academy of Health Sciences. In 2017, she was awarded the Canadian Bioethics Society Lifetime Achievement Award. 

Getting back to the Use Gene Editing to Make Better Babies event page, there are a few options,

Request a Ticket

Have a question? Ask us

There’s also an option to Vote For or Against the Motion but you’ll have to go to the Use Gene Editing to Make Better Babies event page.

Two of the debaters have been mentioned on this blog before, George Church and Françoise Baylis. There are several references to Church including this mention with regard to Dr. He Jiankui and his CRISPR twins (July 28, 2020 posting). Françoise Baylis features in four 2019 postings with the most recent being this October 17, 2019 piece.

For anyone curious about the ‘de-extinction’ debate, it was described here in a January 18, 2019 posting prior to the event.

Who Cares? a series of Art/Sci Salon talks and exhibitions in February and March 2022

COVID-19 has put health care workers in a more than usually interesting position and the Art/Sci Salon in Toronto, Canada is ‘creatively’ addressing the old, new, and emerging stresses. From the Who Cares? events webpage (also in a February 8, 2022 notice received via email),

“Who Cares?” is a Speaker Series dedicated to fostering transdisciplinary conversations between doctors, writers, artists, and researchers on contemporary biopolitics of care and the urgent need to move towards more respectful, creative, and inclusive social practices of care in the wake of the systemic cracks made obvious by the pandemic.

About the Series

Critiques of the health care sector are certainly not new and have been put forward by workers and researchers in the medical sector and in the humanities alike. However, critique alone fails to consider the systemic issues that prevent well-meaning practitioners to make a difference. The goal of this series is to activate practical conversations between people who are already engaged in transforming the infrastructures and cultures of care but have few opportunities to speak to each other. These interdisciplinary dialogues will enable the sharing of emerging epistemologies, new material approaches and pedagogies that could take us beyond the current crisis. By engaging with the arts as research, our guests use the generative insights of poetic and artistic practices to zoom in on the crucial issues undermining holistic, dynamic and socially responsible forms of care. Furthermore, they champion transdisciplinary dialogues and multipronged approaches directed at changing the material and discursive practices of care. 

Who cares? asks the following important questions:

How do we lay the groundwork for sustainable practices of care, that is, care beyond ‘just-in-time’ interventions?

What strategies can we devise to foster genuine transdisciplinary approaches that move beyond the silo effects of specialization, address current uncritical trends towards technological delegation, and restore the centrality responsive/responsible human relations in healthcare delivery?

What practices can help ameliorate the atomizing pitfalls of turning the patient into data?

What pathways can we design to re-direct attention to long lasting care focused on a deeper understanding of the manifold relationalities between doctors, patients, communities, and the socio-environmental context?

How can the critically creative explorations of artists and writers contribute to building resilient communities of care that cultivate reciprocity, respect for the unpredictable temporalities of healing, and active listening?

How to build a capacious infrastructure of care able to address and mend the damages caused by ideologies of ultimate cure that pervade corporate approaches to healthcare funding and delivery?

The first event starts on February 14, 2022 (from the On care, beauty, and Where Things Touch webpage),

On care, beauty, and Where Things Touch

Bahar Orang (University of Toronto, Psychiatry)

Feb. 14 [2022], 10:30 am – 12-30 pm [ET]

This event will be online, please register HERE to participate. After registering, you will receive a confirmation email containing information about joining the meeting. 

A Conversation with Bahar Orang, author of Where Things Touch, on staying attuned to the fragile intimacies of care beyond the stifling demands of institutional environments. 

This short presentation will ask questions about care that move it beyond the carceral logics of hospital settings, particularly in psychiatry. Drawing from questions raised in my first book Where Things Touch, and my work with Doctors for Defunding Police (DFDP), I hope to pose the question of how to do the work of health care differently. As the pandemic has laid bare so much violence, it becomes imperative to engage in forms of political imaginativeness that proactively ask what are the forms that care can take, and does already take, in places other than the clinic or the hospital? 

Bahar Orang is a writer and clinician scholar in the Department of Psychiatry at the University of Toronto. Her creative and clinical work seeks to engage with ways of imagining care beyond the carcerality that medical institutions routinely reproduce

Here’s the full programme from the Who Cares? events webpage,

Opening dialogue
February 14, 10:30-12:30 pm [ET]
On care, beauty, and Where Things Touch

Bahar Orang, University of Toronto, Psychiatry

( Online)

Keynote
Thursday March 10, 1:00-3:00 pm [ET]
Keynote and public reveal of Data meditation

Salvatore Iaconesi and Oriana Persico
independent artists, HER, She Loves Data

(Online)

Roundtables
1. Friday, March 11 – 5:00 to 7:00 pm [ET]
Beyond triage and data culture

Maria Antonia Gonzalez-Valerio, Professor of Philosophy and Literature, UNAM, Mexico City.
Sharmistha Mishra, Infectious Disease Physician and Mathematical Modeller, St Michael’s Hospital
Madhur Anand, Ecologist, School of Environmental Sciences, University of Guelph
Salvatore Iaconesi and Oriana Persico, independent artists, HER, She Loves Data

(Online)

2. Friday, March 18 – 6:00 to 8:00 pm [ET]
Critical care and sustainable care

Suvendrini Lena, MD, Playwright and Neurologist at CAMH and Centre for Headache, Women’s College Hospital, Toronto
Adriana Ieraci, Roboticist and PhD candidate in Computer Science, Ryerson University
Lucia Gagliese – Pain Aging Lab, York University

(online)

3. Friday, March 25 – 5:00 to 7:00 pm [ET]
Building communities and technologies of care

Camille Baker, University for the Creative Arts, School of Film media and Performing Arts
Alanna Kibbe, independent artist, Toronto

(online)

Keynote Conversation
Friday, April 1, 5:00-7:00 pm [ET]
Seema Yasmin,  Director of Research and Education, Stanford Health Communication Initiative [Stanford University]
Bayo Akomolafe,  Chief Curator of The Emergence Network

(hybrid) William Doo Auditorium, 45 Willcox Street, Toronto

Exhibitions
March 24 – April 30

Alanna Kibbe – TRANSFORM: Exploring Languages of Healing. Opening March 31, 5 pm 
Canadian Language Museum, 2275 Bayview Avenue, York University Glendon Campus

(Hybrid event. Limited in person visits by appointment)

Camille Baker INTER/her. Opening April 7, 4 pm [ET]
Ivey Library, 20 Willcox Street, New College, University of Toronto

(Hybrid event. Limited in person visits by appointment)

Closing Presentation and Interactive Session
Karolina Żyniewicz – Signs of the time, Collecting
Biological Traces and Memories

Artist talk: April 8, 4:00-6:00 [ET]
Memory Collection: Apr 9, 2:00-4:00

* The format of this program and access might change with the medical situation

We wish to thank the generous support of the Social Science and Humanities Research Council of Canada,  New College, the D.G. Ivey Library, and the Institute for the History and Philosophy of Science and Technology at the University of Toronto; the Centre for Feminist Research, Sensorium Centre for Digital Arts and Technology, The Canadian Language Museum, the Departments of English and the School of Gender and Women’s Studies at York University. We also wish to thank the support of The Fields Institute for Research in Mathematical Sciences

This series is co-produced in collaboration with the ArtSci Salon

Hopefully, one of those times works for you.

Simon Fraser University (SFU; Vancouver, Canada): Nobel Lectures and Café Scientifique February and March events

I got a February 4, 2022 notice via email that three SFU Science events are planned over the next several weeks.

Nobel Lectures

From the February 4, 2022 SFU Science notice,

Nobel Lectures

Wednesday February 16, 2022, 5:00-7:00 pm [PST] via live stream

Celebrate the 2021 Nobel awardees with us as our faculty members present the awardees’ work as it relates to their own research. Rob Britton from Chemistry, Edgar Young from Molecular Biology and Biochemistry and Kirsten Zickfeld from Geography [likely acting as the host/interviewer] will present at this year’s event.

Register here.

I found some information about the SFU presenters and the work being recognized on the SFU Nobel Prize Lectures 2022 eventbrite webpage,

Dr. Robert Britton completed his PhD at UBC with Professors Edward Piers and Raymond Anderson in 2002 studying natural product isolation and synthesis, and was then an NSERC [Natural Sciences and Engineering Research Council of Canada] Postdoctoral Fellow in Cambridge working with Professor Ian Paterson on the synthesis of structurally complex marine natural products. He then joined the Merck Process Chemistry Group in Montreal before beginning his independent research career at Simon Fraser University in 2005. He is currently a Professor at SFU and his research program focuses on reaction discovery, natural product synthesis, medicinal chemistry and radiopharmaceutical chemistry.

Topic: The catalysis of chemical reactions has historically relied on expensive and often low-abundance metals such as gold, palladium and platinum. The discovery that inexpensive and naturally occurring organic molecules can catalyze the same reactions has caused a paradigm shift that has led to more environmentally friendly and economic processes, and served as an enabling tool for scientific discoveries.

Dr. Edgar Young is an Associate Professor in the Department of Molecular Biology & Biochemistry at SFU. His research lab investigates ion channel proteins that switch their structure in response to electrical and chemical signals, producing complex behaviour in the cardiac and nervous systems.

Topic: The 2021 Nobel Prize in Physiology and Medicine was awarded to David Julius and Ardem Patapoutian, for their discovery of key molecules in our nervous system that enable our sense of touch. In this talk, we’ll see how these molecules called ion channels work as electrical switches to convey sensations of pressure, pain, heat and cold — and we’ll explore the prospects for medical benefit.

From Nobel Prize Lectures 2021:

The Nobel Prize in Physics 2021 was awarded “for groundbreaking contributions to our understanding of complex systems” with one half jointly to Syukuro Manabe and Klaus Hasselmann “for the physical modelling of Earth’s climate, quantifying variability and reliably predicting global warming” and the other half to Giorgio Parisi “for the discovery of the interplay of disorder and fluctuations in physical systems from atomic to planetary scales.”

https://www.nobelprize.org/prizes/physics/2021/summary/

The Nobel Prize in Physiology or Medicine 2021 was awarded jointly to David Julius and Ardem Patapoutian “for their discoveries of receptors for temperature and touch.”

https://www.nobelprize.org/prizes/medicine/2021/summary/

The Nobel Prize in Chemistry 2021 was awarded jointly to Benjamin List and David W.C. MacMillan “for the development of asymmetric organocatalysis.”

https://www.nobelprize.org/prizes/chemistry/2021/summary/

SFU Café Scientifique for February and March 2022

From the February 4, 2022 SFU Science notice,

February 17 & March 24 via Zoom

Engage with award-winning researchers from SFU Science for a series of informal discussions connecting research to important issues of interest to the community.

Aging actively: Why choose to move?

Thursday February 17, 2022, 5:00-6:30 pm

Dr. Dawn Mackey, SFU Biomedical Physiology and Kinesiology

Discover the benefits of regular movement for older adults, explore what they want out of physical activity and find out how to create sustainable habits.

Register here.

[from the eventbrite registration page,

Choosing to move can be as simple as moving more, and moving more often – it doesn’t have to mean going to the gym. In this interactive cafe, Dr. Dawn Mackey from SFU’s Biomedical Physiology and Kinesiology Department will explain the benefits of regular physical activity for older adults, as well as some risks of not being active enough. We will also explore what older adults want to get out of physical activity, and ways to make physical activity a sustainable habit.]

From the South Pole to the edge of the universe, and back to the coast of British Columbia

Thursday March 24, 2022, 5:00-6:30 pm

Dr. Matthias Danninger, SFU Physics

Learn about neutrinos and how British Columbia may soon hold a dominant role in neutrino astronomy.

[from the eventbrite registration page:

What is a neutrino? What can we learn from neutrinos about the Universe? Dr. Matthias Danninger from the Department of Physics will discuss answers to these questions and how British Columbia could play a dominant role for neutrino astronomy in the near future.]

Register here.

Hmmm

I have some comments about both SFU Café Scientifique presentations.

With regard to the “Aging actively: Why choose to move?” event in February 2022, it seems to be oriented to students, i.e., future gerontologists and other professionals focused on geriatrics. I can’t help but notice that the presenter (assuming this photo is relatively recent) is not any danger of being described as aged or as a senior,

Dr. Dawn Mackey [downloaded from https://balancefalls.ubc.ca/people/dawn-mackey]

There is nothing inherently wrong with having a youngish professional share work focused on seniors. The problem lies in the fact that presenters for events/talks/conferences/etc. on older folks are almost always young or youngish. I expect that as these professionals age they will find they are no longer participants in the conversation but the objects of the conversation.

As for “From the South Pole to the edge of the universe, and back to the coast of British Columbia,” this claim seems a little optimistic, “… British Columbia may soon hold a dominant role in neutrino astronomy.”

The centre for neutrino and dark matter physics in Canada is the SNOLAB. (There was a talk about the work at the lab in my June 6, 2019 posting Whispering in the Dark: Updates from Underground Science a June 12, 2019 talk in Vancouver …, another mention of the lab in May 12, 2021 posting about a former SNOLAB executive director, TRIUMF [Canada’s national particle accelerator centre] welcomes Nigel Smith as its new Chief Executive Officer (CEO) on May 17, 2021and …, and, most recently, a September 6, 2021 posting about an art/science exhibit where SNOLAB was a partner, ‘Drift: Art and Dark Matter’ at Vancouver’s … .)

British Columbia will soon be dominant? There was this in 2015 (from the SNOLAB’s Awards and Recognition webpage),

The 2015 Nobel Prize in Physics
2015-10-06
Arthur B. McDonald was co-awarded the 2015 Nobel Prize in Physics with Takaaki Kajita for the contributions of the Sudbury Neutrino Observatory Collaboration and Super-Kamiokande Collaboration for the discovery of neutrino oscillations, which shows that neutrinos have mass. The discovery changed our understanding of the innermost workings of matter and proves crucial to our view of the universe.

While I have doubts about the stated goal of being dominant soon, I look forward to being proved wrong. If that happens.

Cerium-containing nanoparticles in microneedle patches for hair regrowth (a treatment for baldness?)

It’s still being tested but according to an August 11, 2021 news item on ScienceDaily, this is a promising treatment for baldness,

Although some people say that baldness is the “new sexy,” for those losing their hair, it can be distressing. An array of over-the-counter remedies are available, but most of them don’t focus on the primary causes: oxidative stress and insufficient circulation. Now, researchers reporting in ACS Nano have designed a preliminary microneedle patch containing cerium nanoparticles to combat both problems, regrowing hair in a mouse model faster than a leading treatment.

An August 11, 2021 American Chemical Society (ACS) news release (also on EurekAlert) provides more detail (Note: Links have been removed),

The most common hair loss condition is called androgenic alopecia, also known as male- or female- pattern baldness. Hair loss is permanent for people with the condition because there aren’t enough blood vessels surrounding the follicles to deliver nutrients, cytokines and other essential molecules. In addition, an accumulation of reactive oxygen species in the scalp can trigger the untimely death of the cells that form and grow new hair. Previously, Fangyuan Li, Jianqing Gao and colleagues determined that cerium-containing nanoparticles can mimic enzymes that remove excess reactive oxygen species, which reduced oxidative stress in liver injuries, wounds and Alzheimer’s disease. However, these nanoparticles cannot cross the outermost layer of skin. So, the researchers wanted to design a minimally invasive way to deliver cerium-containing nanoparticles near hair roots deep under the skin to promote hair regrowth.

As a first step, the researchers coated cerium nanoparticles with a biodegradable polyethylene glycol-lipid compound. Then they made the dissolvable microneedle patch by pouring a mixture of hyaluronic acid — a substance that is naturally abundant in human skin — and cerium-containing nanoparticles into a mold. The team tested control patches and the cerium-containing ones on male mice with bald spots formed by a hair removal cream. Both applications stimulated the formation of new blood vessels around the mice’s hair follicles. However, those treated with the nanoparticle patch showed faster signs of hair undergoing a transition in the root, such as earlier skin pigmentation and higher levels of a compound found only at the onset of new hair development. These mice also had fewer oxidative stress compounds in their skin. Finally, the researchers found that the cerium-containing microneedle patches resulted in faster mouse hair regrowth with similar coverage, density and diameter compared with a leading topical treatment and could be applied less frequently. Microneedle patches that introduce cerium nanoparticles into the skin are a promising strategy to reverse balding for androgenetic alopecia patients, the researchers say.

The authors acknowledge funding from the Ten-thousand Talents Program of Zhejiang Province, National Key R&D Program of China, National Natural Science Foundation of China, One Belt and One Road International Cooperation Project from the Key Research and Development Program of Zhejiang Province, Fundamental Research Funds for the Central Universities and Zhejiang Provincial Natural Science Foundation of China.

Here’s a link to and a citation for the paper,

Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment by Anran Yuan, Fan Xia, Qiong Bian, Haibin Wu, Yueting Gu, Tao Wang, Ruxuan Wang, Lingling Huang, Qiaoling Huang, Yuefeng Rao, Daishun Ling, Fangyuan Li, and Jianqing Gao. ACS Nano 2021, XXXX, XXX, XXX-XXX DOI: https://doi.org/10.1021/acsnano.1c05272 Publication Date:July 19, 2021 © 2021 American Chemical Society

This paper is behind a paywall.

Artificial ionic neuron for electronic memories

This venture into brain-like (neuromorphic) computing comes from France according to an August 17, 2021 news item on Nanowerk (Note: A link has been removed),

Brain-inspired electronics are the subject of intense research. Scientists from CNRS (Centre national de la recherche scientifique; French National Centre for Scientific Research) and the Ecole Normale Supérieure – PSL have theorized how to develop artificial neurons using, as nerve cells, ions to carry the information.

Their work, published in Science (“Modeling of emergent memory and voltage spiking in ionic transport through angstrom-scale slits”), reports that devices made of a single layer of water transporting ions within graphene nanoslits have the same transmission capacity as a neuron.

Caption Artificial neuron prototype: nanofluidic slits can play the role of ion channels and allow neurons to communicate. Ion clusters achieve the ion transport that causes this communication. Credit © Paul Robin, ENS Laboratoire de Physique (CNRS/ENS-PSL/Sorbonne Université/Université de Paris).

Au August 16, 2021 CNRS press release (also on EurekAlert but published August 6, 2021), which originated the news item, provides insight into the international interest in neuromorphic computing along with a few technical details about this latest research,

With an energy consumption equivalent to two bananas per day, the human brain can perform many complex tasks. Its high energy efficiency depends in particular on its base unit, the neuron, which has a membrane with nanometric pores called ion channels, which open and close according to the stimuli received. The resulting ion flows create an electric current responsible for the emission of action potentials, signals that allow neurons to communicate with each other.

Artificial intelligence can do all of these tasks but only at the cost of energy consumption tens of thousands of times that of the human brain. So the entire research challenge today is to design electronic systems that are as energy efficient as the human brain, for example, by using ions, not electrons, to carry the information. For this, nanofluidics, the study of how fluids behave in channels less than 100 nanometers wide, offer many perspectives. In a new study, a team from the ENS Laboratoire de Physique (CNRS/ENS-PSL/Sorbonne Université/Université de Paris) shows how to construct a prototype of an artificial neuron formed of extremely thin graphene slits containing a single layer of water molecules1. The scientists have shown that, under the effect of an electric field, the ions from this layer of water assemble into elongated clusters and develop a property known as the memristor effect: these clusters retain some of the stimuli that have been received in the past. To repeat the comparison with the brain, the graphene slits reproduce the ion channels, clusters and ion flows. And, using theoretical and digital tools, scientists have shown how to assemble these clusters to reproduce the physical mechanism of emission of action potentials, and thus the transmission of information.

This theoretical work continues experimentally within the French team, in collaboration with scientists from the University of Manchester (UK). The goal now is to prove experimentally that such systems can implement simple learning algorithms that can serve as the basis for tomorrow’s electronic memories.

1 Recently invented in Manchester by the group of André Geim (Nobel Prize in Physics 2010)

Here’s a link to and a citation for the paper,

Modeling of emergent memory and voltage spiking in ionic transport through angstrom-scale slits by Paul Robin, Nikita Kavokine, Lydéric Bocquet. Science 06 Aug 2021: Vol. 373, Issue 6555, pp. 687-691 DOI: 10.1126/science.abf7923

This paper is behind a paywall.

Soft, inflatable, and potentially low-cost neuroprosthetic hand?

An August 16, 2021 news item on ScienceDaily describes a new type of neuroprosthetic,

For the more than 5 million people in the world who have undergone an upper-limb amputation, prosthetics have come a long way. Beyond traditional mannequin-like appendages, there is a growing number of commercial neuroprosthetics — highly articulated bionic limbs, engineered to sense a user’s residual muscle signals and robotically mimic their intended motions.

But this high-tech dexterity comes at a price. Neuroprosthetics can cost tens of thousands of dollars and are built around metal skeletons, with electrical motors that can be heavy and rigid.

Now engineers at MIT [Massachusetts Institute of Technology] and Shanghai Jiao Tong University have designed a soft, lightweight, and potentially low-cost neuroprosthetic hand. Amputees who tested the artificial limb performed daily activities, such as zipping a suitcase, pouring a carton of juice, and petting a cat, just as well as — and in some cases better than — those with more rigid neuroprosthetics.

Here’s a video demonstration,

An August 16, 2021 MIT news news release (also on EurekAlert), which originated the news item, provides more detail,

The researchers found the prosthetic, designed with a system for tactile feedback, restored some primitive sensation in a volunteer’s residual limb. The new design is also surprisingly durable, quickly recovering after being struck with a hammer or run over with a car.

The smart hand is soft and elastic, and weighs about half a pound. Its components total around $500 — a fraction of the weight and material cost associated with more rigid smart limbs.

“This is not a product yet, but the performance is already similar or superior to existing neuroprosthetics, which we’re excited about,” says Xuanhe Zhao, professor of mechanical engineering and of civil and environmental engineering at MIT. “There’s huge potential to make this soft prosthetic very low cost, for low-income families who have suffered from amputation.”

Zhao and his colleagues have published their work today [August 16, 2021] in Nature Biomedical Engineering. Co-authors include MIT postdoc Shaoting Lin, along with Guoying Gu, Xiangyang Zhu, and collaborators at Shanghai Jiao Tong University in China.

Big Hero hand

The team’s pliable new design bears an uncanny resemblance to a certain inflatable robot in the animated film “Big Hero 6.” Like the squishy android, the team’s artificial hand is made from soft, stretchy material — in this case, the commercial elastomer EcoFlex. The prosthetic comprises five balloon-like fingers, each embedded with segments of fiber, similar to articulated bones in actual fingers. The bendy digits are connected to a 3-D-printed “palm,” shaped like a human hand.

Rather than controlling each finger using mounted electrical motors, as most neuroprosthetics do, the researchers used a simple pneumatic system to precisely inflate fingers and bend them in specific positions. This system, including a small pump and valves, can be worn at the waist, significantly reducing the prosthetic’s weight.

Lin developed a computer model to relate a finger’s desired position to the corresponding pressure a pump would have to apply to achieve that position. Using this model, the team developed a controller that directs the pneumatic system to inflate the fingers, in positions that mimic five common grasps, including pinching two and three fingers together, making a balled-up fist, and cupping the palm.

The pneumatic system receives signals from EMG sensors — electromyography sensors that measure electrical signals generated by motor neurons to control muscles. The sensors are fitted at the prosthetic’s opening, where it attaches to a user’s limb. In this arrangement, the sensors can pick up signals from a residual limb, such as when an amputee imagines making a fist.

The team then used an existing algorithm that “decodes” muscle signals and relates them to common grasp types. They used this algorithm to program the controller for their pneumatic system. When an amputee imagines, for instance, holding a wine glass, the sensors pick up the residual muscle signals, which the controller then translates into corresponding pressures. The pump then applies those pressures to inflate each finger and produce the amputee’s intended grasp.

Going a step further in their design, the researchers looked to enable tactile feedback — a feature that is not incorporated in most commercial neuroprosthetics. To do this, they stitched to each fingertip a pressure sensor, which when touched or squeezed produces an electrical signal proportional to the sensed pressure. Each sensor is wired to a specific location on an amputee’s residual limb, so the user can “feel” when the prosthetic’s thumb is pressed, for example, versus the forefinger.

Good grip

To test the inflatable hand, the researchers enlisted two volunteers, each with upper-limb amputations. Once outfitted with the neuroprosthetic, the volunteers learned to use it by repeatedly contracting the muscles in their arm while imagining making five common grasps.

After completing this 15-minute training, the volunteers were asked to perform a number of standardized tests to demonstrate manual strength and dexterity. These tasks included stacking checkers, turning pages, writing with a pen, lifting heavy balls, and picking up fragile objects like strawberries and bread. They repeated the same tests using a more rigid, commercially available bionic hand and found that the inflatable prosthetic was as good, or even better, at most tasks, compared to its rigid counterpart.

One volunteer was also able to intuitively use the soft prosthetic in daily activities, for instance to eat food like crackers, cake, and apples, and to handle objects and tools, such as laptops, bottles, hammers, and pliers. This volunteer could also safely manipulate the squishy prosthetic, for instance to shake someone’s hand, touch a flower, and pet a cat.

In a particularly exciting exercise, the researchers blindfolded the volunteer and found he could discern which prosthetic finger they poked and brushed. He was also able to “feel” bottles of different sizes that were placed in the prosthetic hand, and lifted them in response. The team sees these experiments as a promising sign that amputees can regain a form of sensation and real-time control with the inflatable hand.

The team has filed a patent on the design, through MIT, and is working to improve its sensing and range of motion.

“We now have four grasp types. There can be more,” Zhao says. “This design can be improved, with better decoding technology, higher-density myoelectric arrays, and a more compact pump that could be worn on the wrist. We also want to customize the design for mass production, so we can translate soft robotic technology to benefit society.”

Here’s a link to and a citation for the paper,

A soft neuroprosthetic hand providing simultaneous myoelectric control and tactile feedback by Guoying Gu, Ningbin Zhang, Haipeng Xu, Shaoting Lin, Yang Yu, Guohong Chai, Lisen Ge, Houle Yang, Qiwen Shao, Xinjun Sheng, Xiangyang Zhu, Xuanhe Zhao. Nature Biomedical Engineering (2021) DOI: https://doi.org/10.1038/s41551-021-00767-0 Published: 16 August 2021

This paper is behind a paywall.

Black History Month (February 2022): a Canadian conference and a US magazine cover story

I’ve got two items that feature science in Black History Month 2022.

BE-STEMM

The Canadian Black Scientists Network (CBSN) is holding its first annual Black Excellence Science, Technology, Engineering, Mathematics, Medicine and Health (BE-STEMM) conference Jan. 30-Feb. 2, 2022.

The conference is featured on CBSN’s homepage and it’s where you’ll find a welcome video, which may be livestreaming an event, “Only select public sessions can be viewed here, for full access to all sessions and speakers, please register and join the conference.” Join Conference Register Now!

I did find a bit more information about the conference programme in a January 24, 2022 news item on a University of Saskatchewan (USask) Health Sciences news page (Note: Links have been removed),

The event, sponsored by the USask Office of the President and other major Canadian universities, aims to remove barriers to attracting and retaining Black Canadians in STEMM fields.

“The CBSN was created with the following vision: To elevate, make visible, celebrate and connect Black Canadians in STEMM across sectors. The CBSN is open every Canadian in the STEMM field who identifies as Black,” said University of Saskatchewan (USask) College of Medicine professor and researcher Dr. Erique Lukong (PhD), who serves as vice-president of the CBSN.

The event dates coincide with the beginning of Black History Month, which honours the legacy of Black Canadians and their communities. With the federal government announcing this year’s theme, The Future Is Now, the CBSN BE-STEMM conference provides the perfect opportunity to engage with the discoveries and innovations taking place in Black Canadian research communities.

Lukong is a leader within the CBSN and is a current USask College of Medicine breast cancer researcher who will be presenting at the BE-STEMM conference. His work focuses on analyzing the cellular, physiological and clinical roles of enzymes BRK and FRK in the development and progression of breast cancer.

The BRK enzyme is found to be elevated in 85 per cent of breast cancer tumours and has been found to cause potential drug resistance. The FRK enzyme often goes undetected in triple negative breast cancers – a type of breast cancer where the tumour is missing three important receptors commonly found in other breast cancers.

“I will discuss recent data highlighting the contrasting roles of BRK and FRK in breast cancer and show how these proteins can be targeted to improve breast cancer outcomes and especially in the most vulnerable populations like Black women where there is a disproportionate burden of triple negative breast cancer,” said Lukong.

Another exciting offering of the conference is the Leadership Summit sessions scheduled for Feb. 2 [2022]. The Leadership Summits will be comprised of six concurrent, 90-minute panels, engaging employers, academia, industries, government ministries, health-care professional and funding bodies.

USask College of Medicine assistant professor Dr. Erick McNair (PhD) is one of the facilitators of the Leadership Summit panel discussions.

The CBSN and BE-STEMM were first mentioned here in a November 17, 2021 posting which also noted a Canadian Broadcasting Corporation radio programme, “Quirks & Quarks: Black in science special”which won an award from the American Association for the Advancement of Science (AAAS).

Ebony magazine and Olay highlight ‘Beauty and Brains’

Ebony magazine is going to publish its first paper issue since 2019 for Black History Month February 2022.

Ebony magazine and Olay (currently a skin care brand of US company Proctor & Gamble) sponsored a beauty pageant/contest for the magazine’s cover. From the September 18, 2021 contest page on the Ebony website, Note: HBCU stands for Historically Black Colleges and Universities,

Introducing EBONY’s HBCU STEM Queens Competition

We are pleased to announce EBONY’s HBCU STEM [science, technology, engineering, mathematics] Queens competition. Since 1975, EBONY has celebrated Black collegiate women – poised to make a positive change in the African American community – through the Campus Queens competition at HBCUs (Historically Black Colleges and Universities). EBONY is proud to continue its longest-running editorial franchise. And this year, we’re excited to be partnering with Olay.

Ten beautiful, talented and accomplished HBCU STEM Queens will be featured in EBONY’s Commemorative print issue debuting on newsstands in February 2022.

ELIGIBILITY

Only female students who are STEM majors attending an HBCU are eligible for consideration.

COMPETITION AWARDS

The 10 selected EBONY HBCU STEM Queens with the highest number of votes will win an all-expenses-paid trip to Los Angeles to receive a makeover with professional hair and wardrobe consultation. This trip includes the official “HBCU STEM Queens” photo shoot, which will be featured in the February 2022 Commemorative issue of EBONY magazine as well as online. Students will be notified of the winning group of 10 Queens on October 8, 2021, with subsequent correspondence outlining the schedule and arrangements for the photo shoot.

Meseret Ambachew’s February 1, 2022 article for AdWeek provides more details about the partnership and the upcoming issue of the magazine.

Sarah Mahoney’s January 31, 2022 article for MarketingDaily includes this tidbit,

The special issue celebrates 10 “STEM Queens” from HBCUs, selected by voters on Ebony’s website. Each of the ten winners gets a $10,000 grant, mentorship options from women scientists at P&G, and a trip to Los Angeles for the awards.

Welcome to Black History Month 2022!