I got an email announcement (March 17, 2015) which has acted as a spur to my desire to follow up on my Deux Seurats: one (was an artist) and one (is an inquiry into scientifically sound alternatives to animal testing) of December 26, 2014 post.
First, here’s a March 16, 2015 PETA (People for the Ethical Treatment of Animals) International Science Consortium (PISC) press release which describes a practical and scientific initiative for finding alternatives to animal testing,
Today, the PETA International Science Consortium Ltd. put out a request for proposals (RFP) to identify facilities that can develop an in vitro test that, when used in an integrated approach, has the potential to replace the current test conducted on animals to assess the inhalation toxicity of nanomaterials.
The RFP follows a workshop, organized by the Science Consortium and held at U.S. Environmental Protection Agency headquarters in Washington, D.C., that brought together scientific experts from government, industry, academia, and nonprofit organizations from around the world. The goal of the workshop was to make specific recommendations on the design of this in vitro test, including cell types, endpoints, exposure systems, and dosimetry considerations required to develop the in vitro model.
Based on the recommendations from the workshop, the RFP seeks facilities to develop a method that can assess the induction of pulmonary fibrosis in cells co-cultured at the air-liquid interface following exposure to aerosolized multi-walled carbon nanotubes. The Science Consortium will fund this work.
“For both scientific and ethical reasons, there is interest in developing a non-animal method that is faster, cheaper, and more relevant to the human situation,” says the Science Consortium’s Dr. Amy Clippinger.
The long-term vision is to include this in vitro test in a battery of in silico and in vitro assays that can be used in an integrated testing strategy, providing comprehensive information on biological endpoints relevant to inhalation exposure to nanomaterials to be used in the hazard ranking of substances in the risk-assessment process.
The request for proposals can be found here. The proposal deadline is May 29, 2015.
For more information, please visit PISCLTD.org.uk.
I see the research focus is on multi-walled carbon nanotubes. This makes sense since research has shown that long fibres act like the asbestos fibres they resemble when found in the lung.
Second, I’m hoping to follow up my Deux Seurats piece soon with the tentatively titled, The trouble with mice and … .