Tag Archives: 2013 American Association for the Advancement of Science annual meeting

Chad Mirkin’s periodic table of modified nucleic acid nanoparticles

Chad Mirkin has been pushing his idea for a new periodic table of ‘nanoparticles’ since at least Feb. 2013 (I wrote about this and some of Mirkin’s other work in my Feb. 19, 2013 posting) when he presented it at the 2013 American Association for the Advancement of Science (AAAS) annual meeting in Boston, Massachusetts. From a Feb. 17, 2013 news item on ScienceDaily,

Northwestern University’s Chad A. Mirkin, a leader in nanotechnology research and its application, has developed a completely new set of building blocks that is based on nanoparticles and DNA. Using these tools, scientists will be able to build — from the bottom up, just as nature does — new and useful structures.

Mirkin will discuss his research in a session titled “Nucleic Acid-Modified Nanostructures as Programmable Atom Equivalents: Forging a New Periodic Table” at the American Association for the Advancement of Science (AAAS) annual meeting in Boston.

“We have a new set of building blocks,” Mirkin said. “Instead of taking what nature gives you, we can control every property of the new material we make. [emphasis mine] We’ve always had this vision of building matter and controlling architecture from the bottom up, and now we’ve shown it can be done.”

Mirkin seems a trifle grandiose; I’m hoping he doesn’t have any grand creation projects that require seven days.

Getting back to the new periodic table, the Feb. 13, 2013 Northwestern University news release by Megan Fellman, which originated the news item,  provides a few more details,

Using nanoparticles and DNA, Mirkin has built more than 200 different crystal structures with 17 different particle arrangements. Some of the lattice types can be found in nature, but he also has built new structures that have no naturally occurring mineral counterpart.
Mirkin can make new materials and arrangements of particles by controlling the size, shape, type and location of nanoparticles within a given particle lattice. He has developed a set of design rules that allow him to control almost every property of a material.

New materials developed using his method could help improve the efficiency of optics, electronics and energy storage technologies. “These same nanoparticle building blocks have already found wide-spread commercial utility in biology and medicine as diagnostic probes for markers of disease,” Mirkin added.

With this present advance, Mirkin uses nanoparticles as “atoms” and DNA as “bonds.” He starts with a nanoparticle, which could be gold, silver, platinum or a quantum dot, for example. The core material is selected depending on what physical properties the final structure should have.

He then attaches hundreds of strands of DNA (oligonucleotides) to the particle. The oligonucleotide’s DNA sequence and length determine how bonds form between nanoparticles and guide the formation of specific crystal lattices.

“This constitutes a completely new class of building blocks in materials science that gives you a type of programmability that is extraordinarily versatile and powerful,” Mirkin said. “It provides nanotechnologists for the first time the ability to tailor properties of materials in a highly programmable way from the bottom up.”

Mirkin and his colleagues have since published a paper about this new periodic table in Angewandte Chemie (May 2013). And, earlier today (July 5, 2013) Philip Ball writing (A self-assembled periodic table) for the Royal Society of Chemistry provided a critique of the idea while supporting it in principle,

Mirkin and his colleagues perceive the pairing of [DNA] strands as somewhat analogous to the covalent pairing of electrons and call their DNA-tagged nanoparticles programmable atom equivalents (PAEs). These PAEs may bind to one another according to particular combinatorial rules and Mirkin proposes a kind of periodic table of PAEs that systematises their possible interactions and permutations.
Well, it’s not hard to start enumerating ways in which PAEs are unlike atoms. Most fundamentally, perhaps, the bonding propensity of a PAE need bear no real relation to the ‘atom’ (the nanoparticle) with which it is associated: a given nanoparticle might be paired with any other, and there’s nothing periodic about those tendencies.

I recommend reading Ball’s piece for the way he analyzes the weaknesses and for why he thinks the effort to organize PAEs conceptually is worthwhile.

For the curious, here’s a link to and a citation for the researchers’ published paper,

Nucleic Acid-Modified Nanostructures as Programmable Atom Equivalents: Forging a New “Table of Elements by Robert J. Macfarlane, Matthew N. O’Brien, Dr. Sarah Hurst Petrosko, and Prof. Chad A. Mirkin. Angewandte Chemie International Edition Volume 52, Issue 22, pages 5688–5698, May 27, 2013. Article first published online: 2 MAY 2013 DOI: 10.1002/anie.201209336

Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

This article is behind a paywall.

One final comment, this is not the first ‘nanoparticle table of elements’.  Larry Bell mentioned one in his Dec. 7, 2010 NISENet (Nanoscale Informal Science Education Network) blog posting,

The focus of today’s sessions at NSF’s [US National Science Foundation] meeting of nanoscale science and engineering grantees focuses on putting the science to practical use. First up this morning is nanomanufacturing. Mark Tuonimen from the University of Massachusetts at Amherst gave a talk about the Nanoscale Manufacturing Network and one of his images caught my imagination. This image, which comes from the draft Nano2 vision document on the next decade of nanoscale research, illustrates and idea that is sometimes referred to as a periodic table of nanoparticles.

[downloaded from http://www.nisenet.org/blogs/observations_insights/periodic_table_nanoparticles]

[downloaded from http://www.nisenet.org/blogs/observations_insights/periodic_table_nanoparticles]

Bell goes on to describe one way in which a nanoparticle table of elements would have to differ from the traditional chemistry table.