Tag Archives: Alysson Muotri

Spotlighting space science and transformative science at SXSW 2025 March 7 – 15, 2025

Thank goodness for Julian Dossett’s March 3, 2025 posting on space.com for helping me find the science (more or less) oriented events at the upcoming 2025 South by Southwest (SXSW) Conference and Festivals in Austin, Texas, US.

Space

Dossett’s March 3, 2025 posting describes the best (always a subjective category) space-themed panels,

Meet the astronauts flying on NASA’s Artemis 2 moon mission

March 7 from 11:30 a.m. to 12:30 p.m. CST, Austin Convention Center, Ballroom EF

Learn about Europe’s Euclid ‘dark universe’ space telescope

March 10 from 2:30 p.m. to 3:30 p.m. CST; Austin Marriott Downtown, Waterloo Ballroom 1-2

The era of the private moon lander

March 10 at 4:00 p.m. to 5:00 p.m. CST; Austin Marriott Downtown, Waterloo Ballroom 1-2

Telescopes of the future

March 9 from 11:30 a.m. to 12:30 p.m. CST; Austin Marriott Downtown, Waterloo Ballroom 3

The US National Aeronautics and Space Administration (NASA)has a complete list of their events on its NASA Events at South by Southwest 2025 webpage, Note: The first event listed here is pre-SXSW 2025’s March 7 – 15, 2025 conference/festival,

Perspectives on Working at Scale in K-12 STEAM [science, technology, engineering, arts, mathematics] Education

March 6 at 10 a.m. CST

A growing focus of workforce development efforts are linkages to K-12 in and out-of-school time programs that spark curiosity in STEAM. A cross-section of organizations from the non-profit, commercial and government sector who have used high interest content to build and scale programs in the US and beyond will share lessons learned and perspectives. Topics include building community and youth voice in design, engaging the entire STEM ecosystem, supporting educators and stakeholders in implementation, along with lessons on evaluation and metrics. More Details about Perspectives on Working at Scale in K-12 STEAM Education

Featured Session: Meet the Astronauts Going to the Moon with NASA’s Artemis II

March 7 at 11:30 a.m. CST

Fly me to the Moon! Learn firsthand from the Moon-bound astronauts of NASA’s Artemis II mission, the first crewed mission to deep space in over half a century. Following the successful Artemis I flight test in 2022, Artemis II will test the deep exploration systems needed to establish long-term infrastructure for human lunar exploration. Take a walk in their spacesuits as they share their stories before their much-anticipated flight. More Details

NASA’s Science and Art of Imaging Extra-Terrestrial Samples

March 7 at 2:30 p.m. CST

Meet NASA’s artists and scientists who use specialized imaging techniques to bring extra-terrestrial samples to the public and important data to scientists. From ultra high-resolution photographs to X-ray computed tomography (XCT) that allows you to virtually slice through Moon rocks, meteorites, and the OSIRIS-REx asteroid Bennu samples, their work opens access to other-worldly geologic treasures and could help answer questions about the early days of our solar system. More Details

NASA House: CreateSpace

March 8 at 10 a.m. CST

NASA’s CreateSpace transforms Austin’s Central Library into an immersive experience where visitors don’t just learn about space – they help shape it. Spanning multiple floors of this state-of-the-art library in the heart of downtown Austin, CreateSpace blends hands-on creation, interactive exhibits, and sensory experiences that showcase NASA’s full spectrum of exploration and discovery. Local families will discover through self-guided adventures, while innovation leaders can engage with NASA data and expertise. CreateSpace invites everyone to explore space science through their own lens – whether that’s art, music, technology, or pure imagination. More Details

Performing Space: Weaving Art and Science on the Stage

March 8 at 4 p.m. CST

The intersection of art and science is a consistent hot topic in communication theory, the art realm, academic research, and related industries. Join professionals from NASA’s Jet Propulsion Laboratory, the Los Angeles Department of Cultural Affairs, and the University of California Los Angeles (UCLA) to discuss projects, research, and communication strategies focused on the relationship between science and the arts that can be brought to the stage to inspire audiences from various backgrounds. A special performance viewing will follow this panel. More Details

NASA’s Love Letter: Stunning Webb Images and More

March 9 at 10 a.m. CDT

Join us for an extraordinary journey through the cosmos, guided by stunning images from NASA’s James Webb Space Telescope and other cutting-edge observatories. This session offers a rare opportunity to explore the most distant galaxy ever observed, delve into the atmosphere of an extraterrestrial planet, and marvel at stunningly beautiful star nurseries. Featuring insights from NASA’s Astrophysicists Amber Straughn, Stefanie Milam, and Knicole Colón, our panel will discuss how these groundbreaking observatories are transforming our understanding of the universe. Moderated by Laura Betz. More Details

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NASA Uses Space Tech to Tackle Earth’s Food and Water Issues

March 9 at 2:30 p.m. CDT

In this era of satellite technology, Earth-observing data plays a crucial role in managing food production, farming, and water resources. NASA uses satellite data and advanced technology to gain profound insights into Earth’s systems and the vital environments that sustain us with food and water. By utilizing space-based observations, cutting-edge computer modeling, and AI/ML, NASA collaborates with partner agencies, organizations, farmers, ranchers, fishermen, and global decision-makers to address the challenges related to food and water on Earth. More Details

Through Astronaut Eyes: VR Propels Deep Space Exploration

March 10 at 10 a.m. CDT

Discover how cutting-edge virtual reality technology is revolutionizing deep space exploration. This panel will delve into the ways VR is being used at NASA to simulate and plan next-gen Artemis missions, design spacecraft, help ensure astronaut’s safety, and more. Explore how VR is not just a tool but a transformative technology that is unlocking new frontiers, making the impossible achievable, and preparing humanity for its next giant leap. More Details

Using ESA’s Euclid Telescope To Probe The Dark Universe

March 10 at 2:30 p.m. CDT

95% of the universe is dark: dark matter and dark energy. While we cannot observe them directly, an incredible amount of information about the dark universe is encoded in the shapes, positions, and motions of galaxies. The European Space Agency’s Euclid telescope (with contributions from NASA), launched in July 2023, is the first telescope purpose built to understand the dark universe. Euclid will survey 2 billion galaxies, generating a huge data set that will transform astrophysics using innovative AI/machine learning tools. Euclid’s first release of survey data will be in March 2025. More Details about Using ESA’s Euclid Telescope To Probe The Dark Universe

NASA’s Quesst To Change The Supersonic Speed Limit

March 11 at 10 a.m. CDT

NASA’s Quesst mission may open the future to a new market of commercial supersonic air travel by cutting flight times in half. Learn more about the 50+ year old ban on commercial supersonic travel over land and what NASA is doing to change the speed limit in the sky to a sound limit.
The Quesst mission’s goals are to design and build NASA’s X-59 research aircraft with technology that reduces the loudness of a sonic boom and fly the X-59 over several U.S. communities to gather data on public responses to the sound generated during supersonic flight and deliver that data set to regulators. More Details

NASA and the Next Frontier in the Battle Against Cancer

March 11 at 11:30 a.m. CDT

Research on the International Space Station has already led to drug and therapy breakthroughs for cancer patients on Earth, with more advancements ahead. NASA is working with the U.S. Department of Health and Human Services and researchers across the federal government to help cut the nation’s cancer death rate by at least 50% in the next 25 years, a goal of the administration’s Cancer Moonshot. Join NASA and industry leaders to discuss the transformative potential of space for cancer research and its promising future, and learn how you can get involved.. More Details

Live, From Space! Visualizing the Future With NASA

March 11 at 11:30 a.m. CDT

For over six decades, NASA has led the way in exploring the cosmos, from historic Moon landings and planetary missions to deploying space telescopes, deflecting asteroids, and returning samples to Earth. By sending both humans and robots equipped with advanced instruments and cameras, NASA offers an immersive journey into the universe, unraveling mysteries about our cosmic existence. Join a panel of communications and imagery experts as they provide a look into NASA’s visual triumphs and preview the innovations that will bring viewers along for the ride as we head back to the Moon and beyond. More Details

Messaging the Moon: Collaborative Storytelling in Space Exploration

March 11 at 2:30 p.m. CDT

NASA is working with the commercial space industry in support of establishing a lunar economy. These Moon missions require advanced coordination and planning to support communication campaign goals across multiple stakeholders and audiences. With so many stakeholders involved, synchronization is the key for success. Join NASA and the first American commercial companies co-piloting this mission to discuss how they’ve refined their approach to collaborative messaging while working toward an actual moonshot. More Details

Transformative science

A March 3, 2025 University of California at San Diego (UC San Diego or UCSD) news release (also on EurekAlert) highlights their participation in the 2025 SXSW programme, which includes an unexpected foray into the world of K-pop and BTS,

The South by Southwest (SXSW) Conference and Festivals — a renowned convergence of pioneers, storytellers, and global visionaries — will take place this year from March 7-15 in Austin, Texas, bringing together a vibrant mix of ideas and innovations. Once again, UC San Diego will take center stage, showcasing cutting-edge research, transformative discussions on critical global challenges and a film premiere.

“UC San Diego’s participation in the 2025 South by Southwest Conference and Festivals reinforces our institution’s passion for interdisciplinary innovation and our commitment to leveraging the intersection of technology, art and science to drive positive change,” said Chancellor Pradeep K. Khosla. “At SXSW, our researchers, innovators and creatives will come together with global visionaries to showcase cutting-edge solutions, spark meaningful conversations, and ignite new ideas that can help address the world’s most pressing challenges.”

From tackling climate change to exploring human longevity and studying cancer in space, UC San Diego’s brightest minds will be featured prominently in a series of thought-provoking presentations, panels and the world premiere of a documentary feature.

Details for each UC San Diego-affiliated event are below, and events are accessible to SXSW attendees unless noted otherwise.

At the panel, The Quest to Capture Carbon and Bend the Curve, Ralph Keeling, Ph.D., a climate scientist and director of the Scripps CO2 Program at UC San Diego’s Scripps Institution of Oceanography, will delve into how rising greenhouse gas emissions are impacting our planet and the new technologies emerging to capture carbon. The panel will discuss what it will take to  reduce atmospheric carbon dioxide and the collaborative efforts required to achieve a more sustainable future.

The Guardians of Youth: Stem Cells & Human Longevity presenter Rob Signer, Ph.D., associate professor of medicine and deputy director of the Stem Cell Discovery Center at the UC San Diego Sanford Stem Cell Institute (SSCI), is presenting a pioneering shift in biomedical science by tackling aging as the fundamental driver of diseases like cancer and Alzheimer’s. By positioning stem cells as the blueprint for longevity, this transformative approach is paving the way for a new era in treating age-related diseases at its very core.

Reconstructing the Human Brain in the Lab” presenter Alysson Muotri, Ph.D., professor of medicine and director of the UC San Diego SSCI Integrated Space Stem Cell Orbital Research Center, will showcase how brain organoids — tiny, lab-grown brain-like structures — are unlocking the secrets of brain evolution, consciousness, and aging. Muotri will also discuss how studying these organoids aboard the International Space Station advances interplanetary exploration and medical research.

The NASA and the Next Frontier in the Battle Against Cancer” panel will feature Catriona Jamieson, M.D., Ph.D., professor of medicine and director of the UC San Diego Sanford Stem Cell Institute, alongside NASA scientists. This groundbreaking discussion will explore how research conducted in microgravity is driving new breakthroughs in cancer treatments, delivering hope to patients on Earth.

The panel, Want to Achieve Health Equity? Democratize Health Data, will bring together Jamieson and Muotri to advocate for democratizing access to health data. By empowering patients to take charge of their health care, the panel will propose actionable steps to bridge health equity gaps.

Finally, the documentary feature “Forever We Are Young” will make its world premiere at SXSW 2025. The documentary – co-directed by Patty Ahn, Ph.D., UC San Diego associate teaching professor of communication, with esteemed documentary filmmaker Grace Lee – dives into the passionate fandom that catapulted the K-pop band BTS into a global household name and captures the powerful spirit of activism and collectivity that make BTS fans a symbol of hope and unity in our ever-fractured world.

SXSW 2025 and its 2050 track (the sciencish sessions)

I found an October 22, 2024 SXSW news release by Jordan Roberts with a preliminary announcement of the various programme tracks for the 2025 SXSW conference, which includes some information about the 2050 track,

Each year, we call upon our incredible creative community to help select the bold ideas for the next SXSW conference through PanelPicker®, our official session proposal and voting platform. From those community votes, insights from our dedicated staff, and guidance from our PanelPicker Evaluators, we’re thrilled to announce over 450 sessions for the 2025 SXSW Conference.

“The SXSW Conference always delivers fresh, forward-thinking and fun content. The sessions announced today once again embody this spirit of innovation and discovery. Come to Austin in March to be informed and inspired by so many thought-leaders from so many different industries who lend their creativity to the life-changing experience that is SXSW.” – Hugh Forrest, Co-President and Chief Programming Officer

Human belonging and connection is a powerful theme across the 2025 Conference programming. Whether it’s examining the line between how tech and AI can bring us closer together or push us apart, or diving into new markets and opportunities, these sessions will inspire new perspectives and help us shape a future we’re excited to step into.

Below is a snapshot of the hundreds of speakers, across 23 curated tracks, who will spark conversations, creativity, and ideas for positive change that will last well beyond March. These industry experts hail from a range of cutting-edge and innovative institutions, including Adidas, Atlantic Records, Electronic Frontier Foundation, Epic Games, Forbes, Frontline, Google, IBM, IDEO, Major League Soccer, McKinsey, Microsoft, NASA, National Basketball Association, Netflix, Scale AI, The Atlantic, VMWare, and Zillow.

And this is just the first announcement! We’re still adding programming, including music demo listening sessions, opportunities for continuing legal education and much more to the March conference lineup. Stay tuned for more information by subscribing to event updates or follow us on LinkedIn, Instagram, Facebook and X for more announcements all season long.

Session Highlights By Track

2050

March 7-10 | The 2050 track focuses on long-term, big-picture thinking with an emphasis on scientific discovery. The programming features topics ranging from quantum computing and space exploration to robotics and foresight best practices — and beyond.

Here are a couple of events that caught my eye, from the 2050 track of the 2025 SXSW conference (sorry, forgot to link to the 2050 page and can’t find it again), Note: For the following, I have kept only the link to the session.

Talking Telescopes: The Future of American Observation

Mar 9, 2025 11:30am – 12:30pm CT Austin Marriott Downtown / Waterloo Ballroom 3

Type: Session

Format: Presentation

Track: 2050

Tag: Space

Octavia Knew: How Black Women are Predicting the Future

Octavia Knew: How Black Women are Predicting the Future

Mar 9, 2025 11:30am – 12:30pm CT Austin Marriott Downtown / Waterloo Ballroom 1-2

Type: Session

Format: Panel

Track: 2050

Tag: Women

Tag: DEIB

Tag: Futurism

Preparing for a Quantum Leap

Mar 9, 2025 2:30pm – 3:30pm CT Austin Marriott Downtown / Waterloo Ballroom 1-2

Type: Session

Format: Panel

Track: 2050

Tag: Futurism

Tag: Quantum

Hindsight to Foresight: Indigenous Wisdom for the Future

Mar 10, 2025 11:30am – 12:30pm CT Museum of the Future

Presented by: Dubai Future Foundation

Type: Session

Format: Panel

Track: 2050

Tag: MENA Voices

Tag: Futurism

Tag: Community

Final note: for anyone unfamiliar with Octavia E. Butler, from her Wikipedia entry, Note: Links have been removed,

Octavia Estelle Butler (June 22, 1947 – February 24, 2006) was an American science fiction writer who won several awards for her works, including Hugo, Locus, and Nebula awards. In 1995, Butler became the first science-fiction writer to receive a MacArthur Fellowship.[2][3]

Good luck with finding your way around the website and around SXSW 2025 in Austin, Texas.

Cortical spheroids (like mini-brains) could unlock (larger) brain’s mysteries

A March 19, 2021 Northwestern University news release on EurekAlert announces the creation of a device designed to monitor brain organoids (for anyone unfamiliar with brain organoids there’s more information after the news),

A team of scientists, led by researchers at Northwestern University, Shirley Ryan AbilityLab and the University of Illinois at Chicago (UIC), has developed novel technology promising to increase understanding of how brains develop, and offer answers on repairing brains in the wake of neurotrauma and neurodegenerative diseases.

Their research is the first to combine the most sophisticated 3-D bioelectronic systems with highly advanced 3-D human neural cultures. The goal is to enable precise studies of how human brain circuits develop and repair themselves in vitro. The study is the cover story for the March 19 [March 17, 2021 according to the citation] issue of Science Advances.

The cortical spheroids used in the study, akin to “mini-brains,” were derived from human-induced pluripotent stem cells. Leveraging a 3-D neural interface system that the team developed, scientists were able to create a “mini laboratory in a dish” specifically tailored to study the mini-brains and collect different types of data simultaneously. Scientists incorporated electrodes to record electrical activity. They added tiny heating elements to either keep the brain cultures warm or, in some cases, intentionally overheated the cultures to stress them. They also incorporated tiny probes — such as oxygen sensors and small LED lights — to perform optogenetic experiments. For instance, they introduced genes into the cells that allowed them to control the neural activity using different-colored light pulses.

This platform then enabled scientists to perform complex studies of human tissue without directly involving humans or performing invasive testing. In theory, any person could donate a limited number of their cells (e.g., blood sample, skin biopsy). Scientists can then reprogram these cells to produce a tiny brain spheroid that shares the person’s genetic identity. The authors believe that, by combining this technology with a personalized medicine approach using human stem cell-derived brain cultures, they will be able to glean insights faster and generate better, novel interventions.

“The advances spurred by this research will offer a new frontier in the way we study and understand the brain,” said Shirley Ryan AbilityLab’s Dr. Colin Franz, co-lead author on the paper who led the testing of the cortical spheroids. “Now that the 3-D platform has been developed and validated, we will be able to perform more targeted studies on our patients recovering from neurological injury or battling a neurodegenerative disease.”

Yoonseok Park, postdoctoral fellow at Northwestern University and co-lead author, added, “This is just the beginning of an entirely new class of miniaturized, 3-D bioelectronic systems that we can construct to expand the capacity of the regenerative medicine field. For example, our next generation of device will support the formation of even more complex neural circuits from brain to muscle, and increasingly dynamic tissues like a beating heart.”

Current electrode arrays for tissue cultures are 2-D, flat and unable to match the complex structural designs found throughout nature, such as those found in the human brain. Moreover, even when a system is 3-D, it is extremely challenging to incorporate more than one type of material into a small 3-D structure. With this advance, however, an entire class of 3-D bioelectronics devices has been tailored for the field of regenerative medicine.

“Now, with our small, soft 3-D electronics, the capacity to build devices that mimic the complex biological shapes found in the human body is finally possible, providing a much more holistic understanding of a culture,” said Northwestern’s John Rogers, who led the technology development using technology similar to that found in phones and computers. “We no longer have to compromise function to achieve the optimal form for interfacing with our biology.”

As a next step, scientists will use the devices to better understand neurological disease, test drugs and therapies that have clinical potential, and compare different patient-derived cell models. This understanding will then enable a better grasp of individual differences that may account for the wide variation of outcomes seen in neurological rehabilitation.

“As scientists, our goal is to make laboratory research as clinically relevant as possible,” said Kristen Cotton, research assistant in Dr. Franz’s lab. “This 3-D platform opens the door to new experiments, discovery and scientific advances in regenerative neurorehabilitation medicine that have never been possible.”

Caption: Three dimensional multifunctional neural interfaces for cortical spheroids and engineered assembloids Credit: Northwestern University

As for what brain ogranoids might be, Carl Zimmer in an Aug. 29, 2019 article for the New York Times provides an explanation,

Organoids Are Not Brains. How Are They Making Brain Waves?

Two hundred and fifty miles over Alysson Muotri’s head, a thousand tiny spheres of brain cells were sailing through space.

The clusters, called brain organoids, had been grown a few weeks earlier in the biologist’s lab here at the University of California, San Diego. He and his colleagues altered human skin cells into stem cells, then coaxed them to develop as brain cells do in an embryo.

The organoids grew into balls about the size of a pinhead, each containing hundreds of thousands of cells in a variety of types, each type producing the same chemicals and electrical signals as those cells do in our own brains.

In July, NASA packed the organoids aboard a rocket and sent them to the International Space Station to see how they develop in zero gravity.

Now the organoids were stowed inside a metal box, fed by bags of nutritious broth. “I think they are replicating like crazy at this stage, and so we’re going to have bigger organoids,” Dr. Muotri said in a recent interview in his office overlooking the Pacific.

What, exactly, are they growing into? That’s a question that has scientists and philosophers alike scratching their heads.

On Thursday, Dr. Muotri and his colleagues reported that they  have recorded simple brain waves in these organoids. In mature human brains, such waves are produced by widespread networks of neurons firing in synchrony. Particular wave patterns are linked to particular forms of brain activity, like retrieving memories and dreaming.

As the organoids mature, the researchers also found, the waves change in ways that resemble the changes in the developing brains of premature babies.

“It’s pretty amazing,” said Giorgia Quadrato, a neurobiologist at the University of Southern California who was not involved in the new study. “No one really knew if that was possible.”

But Dr. Quadrato stressed it was important not to read too much into the parallels. What she, Dr. Muotri and other brain organoid experts build are clusters of replicating brain cells, not actual brains.

If you have the time, I recommend reading Zimmer’s article in its entirety. Perhaps not coincidentally, Zimmer has an excerpt titled “Lab-Grown Brain Organoids Aren’t Alive. But They’re Not Not Alive, Either.” published in Slate.com,

From Life’s Edge: The Search For What It Means To Be Alive by Carl Zimmer, published by Dutton, an imprint of Penguin Publishing Group, a division of Penguin Random House, LLC. Copyright © 2021 by Carl Zimmer.

Cleber Trujillo led me to a windowless room banked with refrigerators, incubators, and microscopes. He extended his blue-gloved hands to either side and nearly touched the walls. “This is where we spend half our day,” he said.

In that room Trujillo and a team of graduate students raised a special kind of life. He opened an incubator and picked out a clear plastic box. Raising it above his head, he had me look up at it through its base. Inside the box were six circular wells, each the width of a cookie and filled with what looked like watered-down grape juice. In each well 100 pale globes floated, each the size of a housefly head.

Getting back to the research about monitoring brain organoids, here’s a link to and a citation for the paper about cortical spheroids,

Three-dimensional, multifunctional neural interfaces for cortical spheroids and engineered assembloids by Yoonseok Park, Colin K. Franz, Hanjun Ryu, Haiwen Luan, Kristen Y. Cotton, Jong Uk Kim, Ted S. Chung, Shiwei Zhao, Abraham Vazquez-Guardado, Da Som Yang, Kan Li, Raudel Avila, Jack K. Phillips, Maria J. Quezada, Hokyung Jang, Sung Soo Kwak, Sang Min Won, Kyeongha Kwon, Hyoyoung Jeong, Amay J. Bandodkar, Mengdi Han, Hangbo Zhao, Gabrielle R. Osher, Heling Wang, KunHyuck Lee, Yihui Zhang, Yonggang Huang, John D. Finan and John A. Rogers. Science Advances 17 Mar 2021: Vol. 7, no. 12, eabf9153 DOI: 10.1126/sciadv.abf9153

This paper appears to be open access.

According to a March 22, 2021 posting on the Shirley Riley AbilityLab website, the paper is featured on the front cover of Science Advances (vol. 7 no. 12).