Tag Archives: Ankur Sharma

Nano-spray gel to better manage frostbite injuries

While it’s late in the season to be thinking of frostbite in the Northern Hemisphere, there’s always next year. This research from India looks quite promising, assuming you have the gel available when you first get frostbite. From a December 11, 2019 news item on Nanowerk (Note: A link has been removed),

Mountaineers and winter sports enthusiasts know the dangers of frostbite –– the tissue damage that can occur when extremities, such as the nose, ears, fingers and toes, are exposed to very cold temperatures. However, it can be difficult to get treated quickly in remote, snowbound areas.

Now, researchers reporting in ACS Biomaterials Science & Engineering (“Heparin-Encapsulated Metered-Dose Topical “Nano-Spray Gel” Liposomal Formulation Ensures Rapid On-Site Management of Frostbite Injury by Inflammatory Cytokines Scavenging”) have developed a convenient gel that could be sprayed onto frostbite injuries when they occur, helping wounds heal.

A December 11, 2019 American Chemical Society (ACS) news release, which originated the news item, describes frostbite and the nano-spray gel in more detail,

Frostbite causes fluids in the skin and underlying tissues to freeze and crystallize, resulting in inflammation, decreased blood flow and cell death. Extremities are the most affected areas because they are farther away from the body’s core and already have reduced blood flow. If frostbite is not treated soon after the injury, it could lead to gangrene and amputation of the affected parts. Conventional treatments include immersing the body part in warm water, applying topical antibiotic creams or administering vasodilators and anti-inflammatory drugs, but many of these are unavailable in isolated snowy areas, like mountaintops. Others, such as topical medications, could end up freezing themselves. Rahul Verma and colleagues at the Institute of Nano Science and Technology [India] wanted to develop a cold-stable spray gel that could be administered on-site for the immediate treatment of frostbite injuries.

To develop their spray, the researchers packaged heparin, an anticoagulant that improves blood flow by reducing clotting and aiding in blood vessel repair, into liposomes. These lipid carriers helped deliver heparin deep inside the skin. They embedded the heparin-loaded liposomes in a sprayable hydrogel that also contained ibuprofen (a painkiller and anti-inflammatory drug) and propylene glycol, which helped keep the spray from freezing at very low temperatures. When the researchers tested the spray gel on rats with frostbite, they found that the treatment completely healed the injuries within 14 days, whereas untreated injuries were only about 40% healed, and wounds treated with an antibiotic cream were about 80% healed. The spray reduced levels of inflammatory cytokines at the wound site and in the blood circulation, which likely accelerated healing, the researchers say.

The authors acknowledge funding from the Defence Institute of High Altitude Research [India, Ministry of Defence]

Here’s a link to and a citation for the paper,

Heparin-Encapsulated Metered-Dose Topical “Nano-Spray Gel” Liposomal Formulation Ensures Rapid On-Site Management of Frostbite Injury by Inflammatory Cytokines Scavenging by Kalpesh Vaghasiya, Ankur Sharma, Kushal Kumar, Eupa Ray, Suneera Adlakha, Om Prakash Katare, Sunil Kumar Hota, Rahul K. Verma. ACS Biomater. Sci. Eng. 2019, 5, 12, 6617-6631 DOI: https://doi.org/10.1021/acsbiomaterials.9b01486 Publication Date: November 6, 2019 Copyright © 2019 American Chemical Society

This paper is behind a paywall.

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Bendable phones that are partially organic

It’s been about nine  or 10 years since I first heard about bendable phones (my September 29, 2010 posting). The concept keeps popping up from time to time (my April 25, 2017 posting) and this time, we have Australian scientists to thank for this latest work described in an October 5, 2018 news item on Nanowerk (Note: A link has been removed),

Engineers at ANU [Australian National University] have invented a semiconductor with organic and inorganic materials that can convert electricity into light very efficiently, and it is thin and flexible enough to help make devices such as mobile phones bendable (Advanced Materials, “Efficient and Layer-Dependent Exciton Pumping across Atomically Thin Organic–Inorganic Type-I Heterostructures”).

The invention also opens the door to a new generation of high-performance electronic devices made with organic materials that will be biodegradable or that can be easily recycled, promising to help substantially reduce e-waste.

An October 5, 2018 ANU press release (also on EurekAlert but published October 4, 2018) expands on the theme,

The huge volumes of e-waste generated by discarded electronic devices around the world is causing irreversible damage to the environment. Australia produces 200,000 tonnes of e-waste every year – only four per cent of this waste is recycled.

The organic component has the thickness of just one atom – made from just carbon and hydrogen – and forms part of the semiconductor that the ANU team developed. The inorganic component has the thickness of around two atoms. The hybrid structure can convert electricity into light efficiently for displays on mobile phones, televisions and other electronic devices.

Lead senior researcher Associate Professor Larry Lu said the invention was a major breakthrough in the field.

“For the first time, we have developed an ultra-thin electronics component with excellent semiconducting properties that is an organic-inorganic hybrid structure and thin and flexible enough for future technologies, such as bendable mobile phones and display screens,” said Associate Professor Lu from the ANU Research School of Engineering.

PhD researcher Ankur Sharma, who recently won the ANU 3-Minute Thesis competition, said experiments demonstrated the performance of their semiconductor would be much more efficient than conventional semiconductors made with inorganic materials such as silicon.

“We have the potential with this semiconductor to make mobile phones as powerful as today’s supercomputers,” said Mr Sharma from the ANU Research School of Engineering.

“The light emission from our semiconducting structure is very sharp, so it can be used for high-resolution displays and, since the materials are ultra-thin, they have the flexibility to be made into bendable screens and mobile phones in the near future.”

The team grew the organic semiconductor component molecule by molecule, in a similar way to 3D printing. The process is called chemical vapour deposition.

“We characterised the opto-electronic and electrical properties of our invention to confirm the tremendous potential of it to be used as a future semiconductor component,” Associate Professor Lu said.

“We are working on growing our semiconductor component on a large scale, so it can be commercialised in collaboration with prospective industry partners.”

Here’s a link to and a citation for the paper,

Efficient and Layer‐Dependent Exciton Pumping across Atomically Thin Organic–Inorganic Type‐I Heterostructures by Linglong Zhang, Ankur Sharma, Yi Zhu, Yuhan Zhang, Bowen Wang, Miheng Dong, Hieu T. Nguyen, Zhu Wang, Bo Wen, Yujie Cao, Boqing Liu, Xueqian Sun, Jiong Yang, Ziyuan Li. Advanced Materials Volume30, Issue 40 1803986 (October 4, 2018) DOI:https://doi.org/10.1002/adma.201803986 First published [onliine]: 30 August 2018

This paper is behind a paywall.