Tag Archives: biomedical devices

Manipulating light at the nanoscale with kiragami-inspired technique

At left, different patterns of slices through a thin metal foil, are made by a focused ion beam. These patterns cause the metal to fold up into predetermined shapes, which can be used for such purposes as modifying a beam of light. Courtesy of the researchers

Nanokiragami (or nano-kiragami) is a fully fledged field of research? That was news to me as was much else in a July 6, 2018 news item on ScienceDaily,

Nanokirigami has taken off as a field of research in the last few years; the approach is based on the ancient arts of origami (making 3-D shapes by folding paper) and kirigami (which allows cutting as well as folding) but applied to flat materials at the nanoscale, measured in billionths of a meter.

Now, researchers at MIT [Massachusetts Institute of Technology] and in China have for the first time applied this approach to the creation of nanodevices to manipulate light, potentially opening up new possibilities for research and, ultimately, the creation of new light-based communications, detection, or computational devices.

A July 6, 2018 MIT news release (also on EurekAlert), which originated the news item, adds detail,

The findings are described today [July 6, 2018] in the journal Science Advances, in a paper by MIT professor of mechanical engineering Nicholas X Fang and five others. Using methods based on standard microchip manufacturing technology, Fang and his team used a focused ion beam to make a precise pattern of slits in a metal foil just a few tens of nanometers thick. The process causes the foil to bend and twist itself into a complex three-dimensional shape capable of selectively filtering out light with a particular polarization.

Previous attempts to create functional kirigami devices have used more complicated fabrication methods that require a series of folding steps and have been primarily aimed at mechanical rather than optical functions, Fang says. The new nanodevices, by contrast, can be formed in a single folding step and could be used to perform a number of different optical functions.

For these initial proof-of-concept devices, the team produced a nanomechanical equivalent of specialized dichroic filters that can filter out circularly polarized light that is either “right-handed” or “left-handed.” To do so, they created a pattern just a few hundred nanometers across in the thin metal foil; the result resembles pinwheel blades, with a twist in one direction that selects the corresponding twist of light.

The twisting and bending of the foil happens because of stresses introduced by the same ion beam that slices through the metal. When using ion beams with low dosages, many vacancies are created, and some of the ions end up lodged in the crystal lattice of the metal, pushing the lattice out of shape and creating strong stresses that induce the bending.

“We cut the material with an ion beam instead of scissors, by writing the focused ion beam across this metal sheet with a prescribed pattern,” Fang says. “So you end up with this metal ribbon that is wrinkling up” in the precisely planned pattern.

“It’s a very nice connection of the two fields, mechanics and optics,” Fang says. The team used helical patterns to separate out the clockwise and counterclockwise polarized portions of a light beam, which may represent “a brand new direction” for nanokirigami research, he says.

The technique is straightforward enough that, with the equations the team developed, researchers should now be able to calculate backward from a desired set of optical characteristics and produce the needed pattern of slits and folds to produce just that effect, Fang says.

“It allows a prediction based on optical functionalities” to create patterns that achieve the desired result, he adds. “Previously, people were always trying to cut by intuition” to create kirigami patterns for a particular desired outcome.

The research is still at an early stage, Fang points out, so more research will be needed on possible applications. But these devices are orders of magnitude smaller than conventional counterparts that perform the same optical functions, so these advances could lead to more complex optical chips for sensing, computation, or communications systems or biomedical devices, the team says.

For example, Fang says, devices to measure glucose levels often use measurements of light polarity, because glucose molecules exist in both right- and left-handed forms which interact differently with light. “When you pass light through the solution, you can see the concentration of one version of the molecule, as opposed to the mixture of both,” Fang explains, and this method could allow for much smaller, more efficient detectors.

Circular polarization is also a method used to allow multiple laser beams to travel through a fiber-optic cable without interfering with each other. “People have been looking for such a system for laser optical communications systems” to separate the beams in devices called optical isolaters, Fang says. “We have shown that it’s possible to make them in nanometer sizes.”

The team also included MIT graduate student Huifeng Du; Zhiguang Liu, Jiafang Li (project supervisor), and Ling Lu at the Chinese Academy of Sciences in Beijing; and Zhi-Yuan Li at the South China University of Technology. The work was supported by the National Key R&D Program of China, the National Natural Science Foundation of China, and the U.S Air Force Office of Scientific Research.

The researchers have also provided some GIFs,

And,

Here’s a link to and a citation for the paper,

Nano-kirigami with giant optical chirality by Zhiguang Liu, Huifeng Du, Jiafang Li, Ling Lu, Zhi-Yuan Li, and Nicholas X. Fang. Science Advances 06 Jul 2018: Vol. 4, no. 7, eaat4436 DOI: 10.1126/sciadv.aat4436

This paper is open access.

Wearable technology: two types of sensors one from the University of Glasgow (Scotland) and the other from the University of British Columbia (Canada)

Sometimes it’s good to try and pull things together.

University of Glasgow and monitoring chronic conditions

A February 23, 2018 news item on phys.org describes the latest wearable tech from the University of Glasgow,

A new type of flexible, wearable sensor could help people with chronic conditions like diabetes avoid the discomfort of regular pin-prick blood tests by monitoring the chemical composition of their sweat instead.

In a new paper published in the journal Biosensors and Bioelectronics, a team of scientists from the University of Glasgow’s School of Engineering outline how they have built a stretchable, wireless system which is capable of measuring the pH level of users’ sweat.

A February 22, 2018 University of Glasgow press release, which originated the news item, expands on the theme,

Ravinder Dahiya

 Courtesy: University of Glasgow

 

Sweat, like blood, contains chemicals generated in the human body, including glucose and urea. Monitoring the levels of those chemicals in sweat could help clinicians diagnose and monitor chronic conditions such as diabetes, kidney disease and some types of cancers without invasive tests which require blood to be drawn from patients.

However, non-invasive, wearable systems require consistent contact with skin to offer the highest-quality monitoring. Current systems are made from rigid materials, making it more difficult to ensure consistent contact, and other potential solutions such as adhesives can irritate skin. Wireless systems which use Bluetooth to transmit their information are also often bulky and power-hungry, requiring frequent recharging.

The University of Glasgow team’s new system is built around an inexpensively-produced sensor capable of measuring pH levels which can stretch and flex to better fit the contours of users’ bodies. Made from a graphite-polyurethane composite and measuring around a single square centimetre, it can stretch up to 53% in length without compromising performance. It will also continue to work after being subjected to flexes of 30% up to 500 times, which the researchers say will allow it to be used comfortably on human skin with minimal impact on the performance of the sensor.

The sensor can transmit its data wirelessly, and without external power, to an accompanying smartphone app called ‘SenseAble’, also developed by the team. The transmissions use near-field communication, a data transmission system found in many current smartphones which is used most often for smartphone payments like ApplePay, via a stretchable RFID antenna integrated into the system – another breakthrough innovation from the research team.

The smartphone app allows users to track pH levels in real time and was demonstrated in the lab using a chemical solution created by the researchers which mimics the composition of human sweat.

The research was led by Professor Ravinder Dahiya, head of the University of Glasgow’s School of Engineering’s Bendable Electronics and Sensing Technologies (BEST) group.

Professor Dahiya said: “Human sweat contains much of the same physiological information that blood does, and its use in diagnostic systems has the significant advantage of not needing to break the skin in order to administer tests.

“Now that we’ve demonstrated that our stretchable system can be used to monitor pH levels, we’ve already begun additional research to expand the capabilities of the sensor and make it a more complete diagnostic system. We’re planning to add sensors capable of measuring glucose, ammonia and urea, for example, and ultimately we’d like to see a system ready for market in the next few years.”

The team’s paper, titled ‘Stretchable Wireless System for Sweat pH Monitoring’, is published in Biosensors and Bioelectronics. The research was supported by funding from the European Commission and the Engineering and Physical Sciences Research Council (EPSRC).

Here’s a link to and a citation for the paper,

Stretchable wireless system for sweat pH monitoring by Wenting Dang, Libu Manjakkal, William Taube Navaraj, Leandro Lorenzelli, Vincenzo Vinciguerra. Biosensors and Bioelectronics Volume 107, 1 June 2018, Pages 192–202 [Available online February 2018] https://doi.org/10.1016/j.bios.2018.02.025

This paper is behind a paywall.

University of British Columbia (UBC; Okanagan) and monitor bio-signals

This is a completely other type of wearable tech monitor, from a February 22, 2018 UBC news release (also on EurekAlert) by Patty Wellborn (A link has been removed),

Creating the perfect wearable device to monitor muscle movement, heart rate and other tiny bio-signals without breaking the bank has inspired scientists to look for a simpler and more affordable tool.

Now, a team of researchers at UBC’s Okanagan campus have developed a practical way to monitor and interpret human motion, in what may be the missing piece of the puzzle when it comes to wearable technology.

What started as research to create an ultra-stretchable sensor transformed into a sophisticated inter-disciplinary project resulting in a smart wearable device that is capable of sensing and understanding complex human motion, explains School of Engineering Professor Homayoun Najjaran.

The sensor is made by infusing graphene nano-flakes (GNF) into a rubber-like adhesive pad. Najjaran says they then tested the durability of the tiny sensor by stretching it to see if it can maintain accuracy under strains of up to 350 per cent of its original state. The device went through more than 10,000 cycles of stretching and relaxing while maintaining its electrical stability.

“We tested this sensor vigorously,” says Najjaran. “Not only did it maintain its form but more importantly it retained its sensory functionality. We have further demonstrated the efficacy of GNF-Pad as a haptic technology in real-time applications by precisely replicating the human finger gestures using a three-joint robotic finger.”

The goal was to make something that could stretch, be flexible and a reasonable size, and have the required sensitivity, performance, production cost, and robustness. Unlike an inertial measurement unit—an electronic unit that measures force and movement and is used in most step-based wearable technologies—Najjaran says the sensors need to be sensitive enough to respond to different and complex body motions. That includes infinitesimal movements like a heartbeat or a twitch of a finger, to large muscle movements from walking and running.

School of Engineering Professor and study co-author Mina Hoorfar says their results may help manufacturers create the next level of health monitoring and biomedical devices.

“We have introduced an easy and highly repeatable fabrication method to create a highly sensitive sensor with outstanding mechanical and electrical properties at a very low cost,” says Hoorfar.

To demonstrate its practicality, researchers built three wearable devices including a knee band, a wristband and a glove. The wristband monitored heartbeats by sensing the pulse of the artery. In an entirely different range of motion, the finger and knee bands monitored finger gestures and larger scale muscle movements during walking, running, sitting down and standing up. The results, says Hoorfar, indicate an inexpensive device that has a high-level of sensitivity, selectivity and durability.

Hoorfar and Najjaran are both members of the Okanagan node of UBC’s STITCH (SmarT Innovations for Technology Connected Health) Institute that creates and investigates advanced wearable devices.

The research, partially funded by the Natural Sciences and Engineering Research Council, was recently published in the Journal of Sensors and Actuators A: Physical.

Here’s a link to and a citation for the paper,

Low-cost ultra-stretchable strain sensors for monitoring human motion and bio-signals by Seyed Reza Larimi, Hojatollah Rezaei Nejad, Michael Oyatsi, Allen O’Brien, Mina Hoorfar, Homayoun Najjaran. Sensors and Actuators A: Physical Volume 271, 1 March 2018, Pages 182-191 [Published online February 2018] https://doi.org/10.1016/j.sna.2018.01.028

This paper is behind a paywall.

Final comments

The term ‘wearable tech’ covers a lot of ground. In addition to sensors, there are materials that harvest energy, detect poisons, etc.  making for a diverse field.

Tracks of my tears could power smartphone?

So far the researchers aren’t trying to power anything with tears but they have discovered that tears could be used to generate electricity (from an Oct. 2, 2017 news item on phys.org),

A team of Irish scientists has discovered that applying pressure to a protein found in egg whites and tears can generate electricity. The researchers from the Bernal Institute, University of Limerick (UL), Ireland, observed that crystals of lysozyme, a model protein that is abundant in egg whites of birds as well as in the tears, saliva and milk of mammals can generate electricity when pressed. Their report is published today (October 2) in the journal, Applied Physics Letters.

An Oct. 2, 2017 University of Limerick press release (also on EurekAlert), which originated the news item, offers additional detail,

The ability to generate electricity by applying pressure, known as direct piezoelectricity, is a property of materials such as quartz that can convert mechanical energy into electrical energy and vice versa. Such materials are used in a variety of applications ranging from resonators and vibrators in mobile phones to deep ocean sonars and ultrasound imaging. Bone, tendon and wood are long known to possess piezoelectricity.

“While piezoelectricity is used all around us, the capacity to generate electricity from this particular protein had not been explored. The extent of the piezoelectricity in lysozyme crystals is significant. It is of the same order of magnitude found in quartz. However, because it is a biological material, it is non toxic so it could have many innovative applications such as electroactive anti-microbial coatings for medical implants,” explained Aimee Stapleton, the lead author and an Irish Research Council EMBARK Postgraduate Fellow in the Department of Physics and Bernal Institute of UL.

Crystals of lysozyme are easy to make from natural sources. “The high precision structure of lysozyme crystals has been known since 1965,” said structural biologist at UL and co-author Professor Tewfik Soulimane.
“In fact, it is the second protein structure and the first enzyme structure that was ever solved,” he added, “but we are the first to use these crystals to show the evidence of piezoelectricity”.

According to team leader Professor Tofail Syed of UL’s Department of Physics, “Crystals are the gold-standard for measuring piezoelectricity in non-biological materials. Our team has shown that the same approach can be taken in understanding this effect in biology. This is a new approach as scientists so far have tried to understand piezoelectricity in biology using complex hierarchical structures such as tissues, cells or polypeptides rather than investigating simpler fundamental building blocks”.

The discovery may have wide reaching applications and could lead to further research in the area of energy harvesting and flexible electronics for biomedical devices. Future applications of the discovery may include controlling the release of drugs in the body by using lysozyme as a physiologically mediated pump that scavenges energy from its surroundings. Being naturally biocompatible and piezoelectric, lysozyme may present an alternative to conventional piezoelectric energy harvesters, many of which contain toxic elements such as lead.

Professor Luuk van der Wielen, Director of Bernal Institute and Bernal Professor of Biosystems Engineering and Design expressed his delight at this breakthrough by UL scientists.

“The €109-million Bernal Institute has the ambition to impact the world on the basis of top science in an increasingly international context. The impact of this discovery in the field of biological piezoelectricity will be huge and Bernal scientists are leading from the front the progress in this field,” he said.

Here’s a link to and a citation for the paper,

The direct piezoelectric effect in the globular protein lysozyme featured by A. Stapleton, M. R. Noor, J. Sweeney, V. Casey, A. L. Kholkin, C. Silien, A. A. Gandhi, T. Soulimane, and S. A. M. Tofail. Appl. Phys. Lett. 111, 142902 (2017); doi: http://dx.doi.org/10.1063/1.4997446

This paper is open access.

As for Tracks of My Tears,