Tag Archives: Bob McDonald

Xenobots (living robots) that can reproduce

Xenobots (living robots made from African frog (Xenopus laevis) frog cells) can now self-replicate. First mentioned here in a June 21, 2021 posting, xenobots have captured the imagination of various media outlets including the Canadian Broadcasting Corporation’s (CBC) Quirks and Quarks radio programme and blog where Amanda Buckiewicz posted a December 3, 2021 article about the latest xenobot development (Note: Links have been removed),

In a new study, Bongard [Joshua Bongard, a computer scientist at the University of Vermont] and his colleagues from Tufts University and Harvard’s Wyss Institute for Biologically Inspired Engineering found that the xenobots would autonomously collect loose single cells in their environment, gathering hundreds of cells together until new xenobots had formed.

“This took a little bit for us to wrap our minds around,” he said. “There’s no programming here. Instead, we’re designing or shaping these xenobots, and what they do, the way they behave, is based on shape.”

“We take a couple of thousand of those frog cells and we squish them together into a ball and put that in the bottom of a petri dish,” Bongard told Quirks & Quarks host Bob McDonald. 

“If you were to look into the dish, you would see some very small, what look like specks of pepper, moving about in the bottom of the petri dish.”

The xenobots initially received no instruction from humans on how to replicate. But when researchers added extra cells to the dish containing xenobots, they observed that the xenobots would assemble them into piles.

“Cells early in development are sticky,” said Bongard. “If the pile is large enough and the cells stick together, the outer ones on the surface will grow very small hairs, which are called cilia. And eventually, after four days, those cilia will start to beat back and forth like flexible oars, and the pile will start moving.”

“And that’s a child xenobot.” 

A November 29, 2021 Wyss Institute news release by Joshua Brown describes the process a little differently,

To persist, life must reproduce. Over billions of years, organisms have evolved many ways of replicating, from budding plants to sexual animals to invading viruses.

Now scientists at the University of Vermont, Tufts University, and the Wyss Institute for Biologically Inspired Engineering at Harvard University have discovered an entirely new form of biological reproduction—and applied their discovery to create the first-ever, self-replicating living robots.

The same team that built the first living robots (“Xenobots,” assembled from frog cells—reported in 2020) has discovered that these computer-designed and hand-assembled organisms can swim out into their tiny dish, find single cells, gather hundreds of them together, and assemble “baby” Xenobots inside their Pac-Man-shaped “mouth”—that, a few days later, become new Xenobots that look and move just like themselves.

And then these new Xenobots can go out, find cells, and build copies of themselves. Again and again.

In a Xenopus laevis frog, these embryonic cells would develop into skin. “They would be sitting on the outside of a tadpole, keeping out pathogens and redistributing mucus,” says Michael Levin, Ph.D., a professor of biology and director of the Allen Discovery Center at Tufts University and co-leader of the new research. “But we’re putting them into a novel context. We’re giving them a chance to reimagine their multicellularity.” Levin is also an Associate Faculty member at the Wyss Institute.

And what they imagine is something far different than skin. “People have thought for quite a long time that we’ve worked out all the ways that life can reproduce or replicate. But this is something that’s never been observed before,” says co-author Douglas Blackiston, Ph.D., the senior scientist at Tufts University and the Wyss Institute who assembled the Xenobot “parents” and developed the biological portion of the new study.

“This is profound,” says Levin. “These cells have the genome of a frog, but, freed from becoming tadpoles, they use their collective intelligence, a plasticity, to do something astounding.” In earlier experiments, the scientists were amazed that Xenobots could be designed to achieve simple tasks. Now they are stunned that these biological objects—a computer-designed collection of cells—will spontaneously replicate. “We have the full, unaltered frog genome,” says Levin, “but it gave no hint that these cells can work together on this new task,” of gathering and then compressing separated cells into working self-copies.

“These are frog cells replicating in a way that is very different from how frogs do it. No animal or plant known to science replicates in this way,” says Sam Kriegman, Ph.D.,  the lead author on the new study, who completed his Ph.D. in Bongard’s lab at UVM and is now a post-doctoral researcher at Tuft’s Allen Center and Harvard University’s Wyss Institute for Biologically Inspired Engineering.

Both Buckiewicz’s December 3, 2021 article and Brown’s November 29, 2021 Wyss Institute news release are good reads with liberal used of embedded images. If you have time, start with Buckiewicz as she provides a good introduction and follow up with Brown who gives more detail and has an embedded video of a December 1, 2021 panel discussion with the scientists behind the xenobots.

Here’s a link to and a citation for the latest paper,

Kinematic self-replication in reconfigurable organisms by Sam Kriegman, Douglas Blackiston, Michael Levin, and Josh Bongard. PNAS [Proceedings of the National Academy of Sciences] December 7, 2021 118 (49) e2112672118; https://doi.org/10.1073/pnas.2112672118

This paper appears to be open access.

FrogHeart casts an eye back to 2021 then looks forward to 2022 and contronyms

Casting an eye back isn’t one of my strong points. Thankfully I can’t be forced into making a top 10 list of some kind. Should someone be deeply disappointed (tongue in cheek) that I failed to mention one of the big 2021 stories featured here, please leave a note in the Comments for this blog and I’ll do my best to add it.

Note: I very rarely feature space exploration unless there’s a nanotechnology or other emerging technology angle to it. There are a lot of people who do a much better job of covering space exploration than I can. (If you’re interested in an overview from a Canadian on the international race to space, you can start with this December 29, 2021 posting “Looking back at a booming year in space” by Bob McDonald of CBC’s [Canadian Broadcasting Corporation] Quirks & Quarks science radio programme.)

Now, onto FrogHeart’s latest year.

2021

One of the standout stories in 2020/21 here and many, many places was the rise of the biotechnology community in British Columbia and elsewhere in Canada. Lipid nanoparticles used in COVID-19 vaccines became far better known than they ever had before and AbCellera took the business world by storm as its founder became a COVID billionaire.

Here is a sampling of the BC biotechnology/COVID-19 stories featured here,

  • “Avo Media, Science Telephone, and a Canadian COVID-19 billionaire scientist” December 30, 2020 posting
  • “Why is Precision Nanosystems Inc. in the local (Vancouver, Canada) newspaper?” January 22, 2021 posting Note: The company is best known for its work on lipid nanoparticles
  • “mRNA, COVID-19 vaccines, treating genetic diseases before birth, and the scientist who started it all” March 5, 2021 posting Note: This posting also notes a Canadian connection in relation mRNA in the subsection titled “Entrepreneurs rush in”
  • “Getting erased from the mRNA/COVID-19 story” August 20, 2021 posting Note: This features a fascinating story from Nathan Vardi (for Forbes) of professional jealousies, competitiveness, and a failure to recognize opportunity when she comes visiting.
  • “Who’s running the life science companies’ public relations campaign in British Columbia (Vancouver, Canada)?” August 23, 2021 posting Note: This explores the biotech companies, the network, and provincial and federal funding, as well as, municipal (City of Vancouver) support and more.

Sadly, I did not have time to feature this September 14, 2021 article (The tangled history of mRNA vaccines; Hundreds of scientists had worked on mRNA vaccines for decades before the coronavirus pandemic brought a breakthrough.) by Elie Dolgin for Nature magazine.

Dolgin starts the story in 1987 and covers many players that were new to me although I did recognize some of the more recent and Canadian players such as Pieter Cullis and Ian MacLachlan. *ETA January 3 ,2021: Cullis and MacLachlan are both mentioned in my ‘Getting erased ..” August 20, 2021 posting.* Fun fact: Pieter Cullis was just named an Officer to the Order of Canada (from the Governor General’s December 29, 2021 news release),

Pieter Cullis, O.C.
Vancouver, British Columbia

For his contributions to the advancement of biomedical research and drug development, and for his mentorship of the next generation of scientists and entrepreneurs.

Back to this roundup, I got interested in greener lithium mining, given its importance for batteries in electric vehicles and elsewhere,

2021 seems to have been the year when the science community started podcasting in a big way. Either the podcast was started this year or I stumbled across it this year (meaning it’s likely a podcast that is getting publicized because they had a good first year and they want more listeners for their second year),

  • “New podcast—Mission: Interplanetary and Event Rap: a one-stop custom rap shop Kickstarter” April 30, 2021 posting
  • “Superstar engineers and fantastic fiction writers podcast series” June 28, 2021 posting
  • “Periodically Political: a Canadian podcast from Elect STEM” August 16, 2021 posting
  • “Unlocking Science: a new podcast series launches on November 16, 2021” November 16, 2021 posting
  • “Lost Women of Science” December 2, 2021 posting
  • “Nerdin’ About and Science Diction: a couple of science podcasts” Note: Not posted but maybe one day. Meanwhile, here they are:
    • Nerdin’ About describes itself as, “… a podcast where passionate nerds tell us about their research, their interests, and what they’ve been Nerdin’ About lately. A spin-off of Nerd Nite Vancouver, a community lecture series held in a bar, Nerdin’ About is here to explore these questions with you. Hosted by rat researcher Kaylee Byers (she/her) and astronomy educator Michael Unger (he/him). Elise Lane (she/her) is our Mixing Engineer. Music by Jay Arner. Artwork by Armin Mortazavi.”
    • Science Diction is a podcast offshoot of Science Friday (SciFri), a US National Public Radio (NPR) programme. “… Hosted by SciFri producer and self-proclaimed word nerd Johanna Mayer, each episode of Science Diction digs into the origin of a single word or phrase, and, with the help of historians, authors, etymologists, and scientists, reveals a surprising science connection. Did you know the origin of the word meme has more to do with evolutionary biology than lolcats? Or that the element cobalt takes its name from a very cheeky goblin from German folklore? …”
  • Podcast episode from the Imperial College London features women’s hearts, psychedelic worldviews, and nanotechnology for children” Note: Not posted but maybe one day.
  • Alberta-based podcast explores AI (Artificial Intelligence)” Note 1: You’ll find season one and two on the page I’ve linked to; just keep scrolling. Note 2: Not posted but maybe one day.
  • Own the Science Podcast/À vous la science balado” Note: Not posted but maybe one day.

Integrating the body with machines is an ongoing interest of mine, these particular 2021 postings stood out but there are other postings (click on the Human Enhancement category or search the tag ‘machine/flesh’),

I wrote a few major (long) pieces this year,

  • “Interior Infinite: carnival & chaos, a June 26 – September 5, 2021 show at Polygon Art Gallery (North Vancouver, Canada)” July 26, 2021 posting Note: While this isn’t an art/sci posting it does touch on a topic near and dear to my heart, writers. In particular, the literary theorist, Mikhail Mikhailovich Bakhtin.
  • “The metaverse or not” October 22, 2021 posting Note: What can I say? The marketing hype got to me.
  • “True love with AI (artificial intelligence): The Nature of Things explores emotional and creative AI (long read)” December 3, 2021 posting

2022 and contronyms

I don’t make psychic predictions. As far as I’m concerned, 2022 will be a continuation of 2021, albeit with a few surprises.

My focus on nanotechnology and emerging technologies will remain. I expect artificial intelligence, CRISPR and gene editing (in general), quantum computing (technical work and commercialization), and neuromorphic computing will continue to make news. As for anything else, well, it wouldn’t be a surprise if you knew it was coming.

With regard to this blog, I keep thinking about cutting back so I can focus on other projects. Whether I finally follow through this year is a mystery to me.

Because words and writing are important to me, I’d like to end the year with this, which I found in early December 2021. From “25 Words That Are Their Own Opposites” on getpocket.com by Judith Herman originally written for “Mental Floss and … published June 15, 2018,”

Here’s an ambiguous sentence for you: “Because of the agency’s oversight, the corporation’s behavior was sanctioned.” Does that mean, “Because the agency oversaw the company’s behavior, they imposed a penalty for some transgression,” or does it mean, “Because the agency was inattentive, they overlooked the misbehavior and gave it their approval by default”? We’ve stumbled into the looking-glass world of contronyms—words that are their own antonyms.

1. Sanction (via French, from Latin sanctio(n-), from sancire ‘ratify,’) can mean “give official permission or approval for (an action)” or conversely, “impose a penalty on.”

2. Oversight is the noun form of two verbs with contrary meanings, “oversee” and “overlook.” Oversee, from Old English ofersēon (“look at from above”) means “supervise” (medieval Latin for the same thing: super-, “over” plus videre, “to see.”) Overlook usually means the opposite: “to fail to see or observe; to pass over without noticing; to disregard, ignore.”

3. Left can mean either remaining or departed. If the gentlemen have withdrawn to the drawing room for after-dinner cigars, who’s left? (The gentlemen have left and the ladies are left.)

4. Dust, along with the next two words, is a noun turned into a verb meaning either to add or to remove the thing in question. Only the context will tell you which it is. When you dust are you applying dust or removing it? It depends whether you’re dusting the crops or the furniture.

The contronym (also spelled “contranym”) goes by many names, including auto-antonym, antagonym, enantiodrome, self-antonym, antilogy and Janus word (from the Roman god of beginnings and endings, often depicted with two faces looking in opposite directions). …

Herman made liberal use, which she acknowledged, of the Mark Nichol article/list, “75 Contronyms (Words with Contradictory Meanings)” on Daily Writing Tips (Note: Based on the ‘comments’, Nichol’s list appears to be have been posted sometime in 2011),

3. Bill: A payment, or an invoice for payment

4. Bolt: To secure, or to flee

46. Quantum: Significantly large, or a minuscule part

47. Quiddity: Essence, or a trifling point of contention

68. Trim: To decorate, or to remove excess from

69. Trip: A journey, or a stumble

Happy 2022!

General Fusion moves headquarters to Vancouver Airport (sort of)

Nuclear energy is not usually of much interest to me but there is a Canadian company doing some interesting work in that area. So, before getting to the news about the company’s move, here’s a general description of fusion energy and how General Fusion (the company) is approaching the clean energy problem, from a June 18, 2021 posting by Bob McDonald on the Canadian Broadcasting Corporation’s (CBC) Quirks and Quarks blog (Note: Links have been removed),

Vancouver-based fusion energy company General Fusion has entered an agreement with the United Kingdom Atomic Energy Authority to build a nuclear fusion demonstration plant to be operational in 2025. It will take a unique approach to generating clean energy.   

There is an industry joke that fusion energy has been 20 years away for 50 years. The quest to produce clean energy by duplicating the processes happening at the centre of the sun has been a difficult and expensive challenge.

It has yet to be accomplished on anything like a commercial scale. That is partly because on Earth the fusion process involves handling materials at extreme pressures and temperatures many times hotter than the surface of the sun.

The nuclear technology that has provided electricity for decades around the world relies on fission, which splits heavy atoms such as uranium into lighter elements, releasing energy. However, this produces hazardous and durable radioactive waste that must be stored, and more catastrophically has led to major accidents at Chernobyl and Fukushima.

Fusion is the opposite of fission. Lighter elements such as hydrogen are heated and compressed to fuse into heavier ones. This releases energy, but with a much smaller legacy of radioactive waste, and no risk of meltdown.

The world’s largest fusion reactor experiment, ITER (Latin for “the way”) [International Thermonuclear Experimental Reactor] is currently under construction in southern France. It’s a massive international collaboration developing on fusion technology that’s been been explored since it was invented in the Soviet Union in the 1950s. It involves a doughnut-shaped metallic chamber called a tokamak that is surrounded by incredibly powerful superconducting magnets. 

An electrically charged gas, or plasma, will be injected into the chamber where the magnets hold it, compressed and suspended, so it does not touch the walls and burn through them. The plasma will be heated to the unbelievable temperature of 150 million C, when fusion begins to take place.

And therein lies the problem. So far, experimental fusion reactors have required more energy to heat the plasma to start the fusion reaction than can be harvested from the reaction itself. Size is part of the problem. Demonstration reactors are small and meant to test equipment and materials, not produce power. ITER is supposed to be large enough to produce 10 times as much power as is required to heat up its plasma.

And that’s the holy grail of fusion: to produce enough power that the nuclear fusion reaction can become self-sustaining.

General Fusion takes a completely different approach by using mechanical pressure to contain and heat the plasma, rather than gigantic electromagnets. A series of powerful pistons surround a container of liquid metal with the hydrogen plasma in the centre. The pistons mechanically squeeze the liquid on all sides at once, heating the fuel by compression the way fuel in a diesel engine is compressed and heated in a cylinder until it ignites. 

Exciting, eh? If you have time, you may want to read McDonald’s June 18, 2021 posting for a few more details about General Fusion’s technology and for some embedded images.

At one point I was under the impression that General Fusion was involved with ITER but that seems to have been a misunderstanding on my part.

I first wrote about General Fusion in a December 2, 2011 posting titled: Burnaby-based company (Canada) challenges fossil fuel consumption with nuclear fusion. (For those unfamiliar with the Vancouver area, there’s the city of Vancouver and there’s Vancouver Metro, which includes the city of Vancouver and others in the region. Burnaby is part of Metro Vancouver; General Fusion is moving to Sea Island (near Vancouver Airport), in Richmond, which is also in Metro Vancouver.) Kenneth Chan’s October 20, 2021 article for the Daily Hive gives more detail about General Fusion’s new facilities (Note: A link has been removed),

The new facility will span two buildings at 6020 and 6082 Russ Baker Way, near YVR’s [Vancouver Airport] South Terminal. This includes a larger building previously used for aircraft engine maintenance and repair.

The relocation process could start before the end of 2021, allowing the company to more than quadruple its workforce over the coming years. Currently, it employs about 140 people.

The Sea Island [in Richmond] facility will house its corporate offices, primary fusion technology development division, and many of its engineering laboratories. This new facility provides General Fusion with the ability to build a new demonstration prototype to support the commercialization of its magnetized target fusion technology.

The company’s research and development into practical fusion technology as a zero-carbon power solution to address the world’s growing energy needs, while fighting climate change, is supported by the federal governments of Canada, US, and UK.

General Fusion is backed by dozens of large global private investors, including Bezos Expeditions, which is the personal investment entity for Amazon founder Jeff Bezos. It has raised a total of about USD$200 million in financing to date.

“British Columbia is at the centre of a thriving, world-class technology innovation ecosystem, just the right place for us to continue investing in our growing workforce and the future of our company,” said Christofer Mowry, CEO of General Fusion, in a statement.

Earlier this year, YVR also indicated it is considering allowing commercial and industrial developments on several hundred acres of under-utilized parcels of land next to the north and south runways, for uses that complement airport activities. This would also provide the airport with a new source of revenue, after major financial losses from the years-long impact of COVID-19.

You can find General Fusion here and you can find ITER here.

Sunlight makes transparent wood even lighter and stronger

Researchers at the University of Maryland (US) have found a way to make their wood transparent by using sunlight. From a February 2, 2021 news article by Bob Yirka on phys.org (Note: Links have been removed),

A team of researchers at the University of Maryland, has found a new way to make wood transparent. In their paper published in the journal Science Advances, the group describes their process and why they believe it is better than the old process.

The conventional method for making wood transparent involves using chemicals to remove the lignin—a process that takes a long time, produces a lot of liquid waste and results in weaker wood. In this new effort, the researchers have found a way to make wood transparent without having to remove the lignin.

The process involved changing the lignin rather than removing it. The researchers removed lignin molecules that are involved in producing wood color. First, they applied hydrogen peroxide to the wood surface and then exposed the treated wood to UV light (or natural sunlight). The wood was then soaked in ethanol to further clean it. Next, they filled in the pores with clear epoxy to make the wood smooth.

Caption: Solar-assisted large-scale fabrication of transparent wood. (A) Schematic showing the potential large-scale fabrication of transparent wood based on the rotary wood cutting method and the solar-assisted chemical brushing process. (B) The outdoor fabrication of lignin-modified wood with a length of 1 m [9 August 2019 (the summer months) at 13:00 p.m. (solar noon), the Global Solar UV Index (UVI): 7 to 8]. (C) Digital photo of a piece of large transparent wood (400 mm by 110 mm by 1 mm). (D) The energy consumption, chemical cost, and waste emission for the solar-assisted chemical brushing process and NaClO2 solution–based delignification process. (E) A radar plot showing a comparison of the fabrication process for transparent wood. Photo credit: Qinqin Xia, University of Maryland, College Park. [downloaded from https://advances.sciencemag.org/content/7/5/eabd7342]

Bob McDonald in a February 5, 2021 posting on his Canadian Broadcasting Corporation (CBC) Quirks & Quarks blog provides a more detailed description of the new ‘solar-based transparency process’,

Early attempts to make transparent wood involved removing the lignin, but this involved hazardous chemicals, high temperatures and a lot of time, making the product expensive and somewhat brittle. The new technique is so cheap and easy it could literally be done in a backyard.

Starting with planks of wood a metre long and one millimetre thick, the scientists simply brushed on a solution of hydrogen peroxide using an ordinary paint brush. When left in the sun, or under a UV lamp for an hour or so, the peroxide bleached out the brown chromophores but left the lignin intact, so the wood turned white.

Next, they infused the wood with a tough transparent epoxy designed for marine use, which filled in the spaces and pores in the wood and then hardened. This made the white wood transparent.

As window material, it would be much more resistant to accidental breakage. The clear wood is lighter than glass, with better insulating properties, which is important because windows are a major source of heat loss in buildings. It also might take less energy to manufacture clear wood because there are no high temperatures involved.

Many different types of wood, from balsa to oak, can be made transparent, and it doesn’t matter if it is cut along the grain or against it. If the transparent wood is made a little thicker, it would be strong enough to become part of the structure of a building, so there could be entire transparent wooden walls.

Adele Peters in her February 2, 2021 article for Fast Company describes the work in Maryland and includes some information about other innovative and possibly sustainable uses of wood (Note: Links have been removed),

It’s [transparent wood] just one of a number of ways scientists and engineers are rethinking how we can use this renewable resource in construction. Skyscrapers made entirely out of wood are gaining popularity in cities around the world. And scientists recently discovered a technique to grow wood in a lab, opening up the possibility of using wood without having to chop down a forest.

There were three previous posts here about this work at the University of Maryland,

University of Maryland looks into transparent wood May 11, 2016 posting

Transparent wood more efficient than glass in windows? Sept, 8, 2016 posting

Glass-like wood windows protect against UV rays and insulate heat October 21, 2020 posting

I have this posting, which is also from 2016 but features work in Sweden,

Transparent wood instead of glass for window panes? April 1, 2016 posting

Getting back to the latest work from the University of Maryland, here’s a link to and a citation for the paper,

Solar-assisted fabrication of large-scale, patternable transparent wood by Qinqin Xia, Chaoji Chen, Tian Li, Shuaiming He, Jinlong Gao, Xizheng Wang and Liangbing Hu. Science Advances Vol. 7, no. 5, eabd7342 DOI: 10.1126/sciadv.abd7342 Published: 27 Jan 2021

This paper is open access.

One last item, Liangbing Hu has founded a company InventWood for commercializing the work he and his colleagues have done at the University of Maryland.

Cooking up a lung one way or the other

I have two stories about lungs and they are entirely different with the older one being a bioengineering story from the US and the more recent one being an artificial tissue story from the University of Toronto and the University of Ottawa (both in Canada).

Lab grown lungs

The Canadian Broadcasting Corporation’s Quirks and Quarks radio programme posted a December 29, 2018 news item (with embedded radio files) about bioengineered lunjgs,

There are two major components to building an organ: the structure and the right cells on that structure. A team led by Dr. Joan Nichols, a Professor of Internal Medicine, Microbiology and Immunology at the University of Texas Medical Branch in Galveston, were able to tackle both parts of the problem

In their experiment they used a donor organ for the structure. They took a lung from an unrelated pig, and stripped it of its cells, leaving a scaffold of collagen, a tough, flexible protein.  This provided a pre-made appropriate structure, though in future they think it may be possible to use 3-D printing technology to get the same result.

They then added cultured cells from the animal who would be receiving the transplant – so the lung was made of the animal’s own cells. Cultured lung and blood vessel cells were placed on the scaffold and it was  placed in a tank for 30 days with a cocktail of nutrients to help the cells stick to the scaffold and proliferate. The result was a kind of baby lung.

They then transplanted the bio-engineered, though immature, lung into the recipient animal where they hoped it would continue to develop and mature – growing to become a healthy, functioning organ.

The recipients of the bio-engineered lungs were four pigs adult pigs, which appeared to tolerate the transplants well. In order to study the development of the bio-engineered lungs, they euthanized the animals at different times: 10 hours, two weeks, one month and two months after transplantation.

They found that as early as two weeks, the bio-engineered lung had integrated into the recipient animals’ body, building a strong network of blood vessels essential for the lung to survive. There was no evidence of pulmonary edema, the build of fluid in the lungs, which is usually a sign of the blood vessels not working efficiently.  There was no sign of rejection of the transplanted organs, and the pigs were healthy up to the point where they were euthanized.

One lingering concern is how well the bio-engineered lungs delivered oxygen. The four pigs who received the trasplant [sic] had one original functioning lung, so they didn’t depend on their new bio-engineered lung for breathing. The scientists were not sure that the bio-engineered lung was mature enough to handle the full load of oxygen on its own.

You can hear Bob McDonald’s (host of Quirks & Quarks, a Canadian Broadcasting Corporation science radio programme) interview lead scientist, Dr. Joan Nichols if you go to here. (Note: I find he overmodulates his voice but some may find he has a ‘friendly’ voice.)

This is an image of the lung scaffold produced by the team,

Lung scaffold in the bioreactor chamber on Day 1 of the experiment, before the cells from the study pig were added. (Credit: Joan Nichols) [downloaded from https://www.cbc.ca/radio/quirks/dec-29-2018-water-on-mars-lab-grown-lungs-and-more-the-biggest-science-stories-of-2018-1.4940811/lab-grown-lungs-are-transplanted-in-pigs-today-they-may-help-humans-tomorrow-1.4940822]

Here’s more technical detail in an August 1, 2018i University of Texas Medical Branch (UTMB) news release (also on EurekAlert), which originally announced the research,

A research team at the University of Texas Medical Branch at Galveston have bioengineered lungs and transplanted them into adult pigs with no medical complication.

In 2014, Joan Nichols and Joaquin Cortiella from The University of Texas Medical Branch at Galveston were the first research team to successfully bioengineer human lungs in a lab. In a paper now available in Science Translational Medicine, they provide details of how their work has progressed from 2014 to the point no complications have occurred in the pigs as part of standard preclinical testing.

“The number of people who have developed severe lung injuries has increased worldwide, while the number of available transplantable organs have decreased,” said Cortiella, professor of pediatric anesthesia. “Our ultimate goal is to eventually provide new options for the many people awaiting a transplant,” said Nichols, professor of internal medicine and associate director of the Galveston National Laboratory at UTMB.

To produce a bioengineered lung, a support scaffold is needed that meets the structural needs of a lung. A support scaffold was created using a lung from an unrelated animal that was treated using a special mixture of sugar and detergent to eliminate all cells and blood in the lung, leaving only the scaffolding proteins or skeleton of the lung behind. This is a lung-shaped scaffold made totally from lung proteins.

The cells used to produce each bioengineered lung came from a single lung removed from each of the study animals. This was the source of the cells used to produce a tissue-matched bioengineered lung for each animal in the study. The lung scaffold was placed into a tank filled with a carefully blended cocktail of nutrients and the animals’ own cells were added to the scaffold following a carefully designed protocol or recipe. The bioengineered lungs were grown in a bioreactor for 30 days prior to transplantation. Animal recipients were survived for 10 hours, two weeks, one month and two months after transplantation, allowing the research team to examine development of the lung tissue following transplantation and how the bioengineered lung would integrate with the body.

All of the pigs that received a bioengineered lung stayed healthy. As early as two weeks post-transplant, the bioengineered lung had established the strong network of blood vessels needed for the lung to survive.

“We saw no signs of pulmonary edema, which is usually a sign of the vasculature not being mature enough,” said Nichols and Cortiella. “The bioengineered lungs continued to develop post-transplant without any infusions of growth factors, the body provided all of the building blocks that the new lungs needed.”

Nichols said that the focus of the study was to learn how well the bioengineered lung adapted and continued to mature within a large, living body. They didn’t evaluate how much the bioengineered lung provided oxygenation to the animal.

“We do know that the animals had 100 percent oxygen saturation, as they had one normal functioning lung,” said Cortiella. “Even after two months, the bioengineered lung was not yet mature enough for us to stop the animal from breathing on the normal lung and switch to just the bioengineered lung.”

For this reason, future studies will look at long-term survival and maturation of the tissues as well as gas exchange capability.

The researchers said that with enough funding, they could grow lungs to transplant into people in compassionate use circumstances within five to 10 years.

“It has taken a lot of heart and 15 years of research to get us this far, our team has done something incredible with a ridiculously small budget and an amazingly dedicated group of people,” Nichols and Cortiella said.

Here’s a citation and another link for the paper,

Production and transplantation of bioengineered lung into a large-animal model by Joan E. Nichols, Saverio La Francesca, Jean A. Niles, Stephanie P. Vega, Lissenya B. Argueta, Luba Frank, David C. Christiani, Richard B. Pyles, Blanca E. Himes, Ruyang Zhang, Su Li, Jason Sakamoto, Jessica Rhudy, Greg Hendricks, Filippo Begarani, Xuewu Liu, Igor Patrikeev, Rahul Pal, Emiliya Usheva, Grace Vargas, Aaron Miller, Lee Woodson, Adam Wacher, Maria Grimaldo, Daniil Weaver, Ron Mlcak, and Joaquin Cortiella. Science Translational Medicine 01 Aug 2018: Vol. 10, Issue 452, eaao3926 DOI: 10.1126/scitranslmed.aao3926

This paper is behind a paywall.

Artificial lung cancer tissue

The research teams at the University of Toronto and the University of Ottawa worked on creating artificial lung tissue but other applications are possible too. First, there’s the announcement in a February 25, 2019 news item on phys.org,

A 3-D hydrogel created by researchers in U of T Engineering Professor Molly Shoichet’s lab is helping University of Ottawa researchers to quickly screen hundreds of potential drugs for their ability to fight highly invasive cancers.

Cell invasion is a critical hallmark of metastatic cancers, such as certain types of lung and brain cancer. Fighting these cancers requires therapies that can both kill cancer cells as well as prevent cell invasion of healthy tissue. Today, most cancer drugs are only screened for their ability to kill cancer cells.

“In highly invasive diseases, there is a crucial need to screen for both of these functions,” says Shoichet. “We now have a way to do this.”

A February 25, 2019 University of Toronto news release (also on EurekAlert), which originated the news item, offers more detail ,

In their latest research, the team used hydrogels to mimic the environment of lung cancer, selectively allowing cancer cells, and not healthy cells, to invade. In their latest research, the team used hydrogels to mimic the environment of lung cancer, selectively allowing cancer cells, and not healthy cells, to invade. This emulated environment enabled their collaborators in Professor Bill Stanford’s lab at University of Ottawa to screen for both cancer-cell growth and invasion. The study, led by Roger Y. Tam, a research associate in Shochet’s lab, was recently published in Advanced Materials.

“We can conduct this in a 384-well plate, which is no bigger than your hand. And with image-analysis software, we can automate this method to enable quick, targeted screenings for hundreds of potential cancer treatments,” says Shoichet.

One example is the researchers’ drug screening for lymphangioleiomyomatosis (LAM), a rare lung disease affecting women. Shoichet and her team were inspired by the work of Green Eggs and LAM, a Toronto-based organization raising awareness of the disease.

Using their hydrogels, they were able to automate and screen more than 800 drugs, thereby uncovering treatments that could target disease growth and invasion.

In the ongoing collaboration, the researchers plan to next screen multiple drugs at different doses to gain greater insight into new treatment methods for LAM. The strategies and insights they gain could also help identify new drugs for other invasive cancers.

Shoichet, who was recently named a Distinguished Woman in Chemistry or Chemical Engineering, also plans to patent the hydrogel technology.

“This has, and continues to be, a great collaboration that is advancing knowledge at the intersection of engineering and biology,” says Shoichet.

I note that Shoichet (pronounced ShoyKet) is getting ready to patent this work. I do have a question about this and it’s not up to Shoichet to answer as she didn’t create the system. Will the taxpayers who funded her work receive any financial benefits should the hydrogel prove to be successful or will we be paying double, both supporting her research and paying for the hydrogel through our healthcare costs?

Getting back to the research, here’s a link to and a citation for the paper,

Rationally Designed 3D Hydrogels Model Invasive Lung Diseases Enabling High‐Content Drug Screening by Roger Y. Tam, Julien Yockell‐Lelièvre, Laura J. Smith, Lisa M. Julian, Alexander E. G. Baker, Chandarong Choey, Mohamed S. Hasim, Jim Dimitroulakos, William L. Stanford, Molly S. Shoichet. Advanced Materials Volume 31, Issue 7 February 15, 2019 1806214 First published online: 27 December 2018 DOI: https://doi.org/10.1002/adma.201806214

This paper is behind a paywall.

Happy Thanksgiving! Oct. 12, 2015, my last mention of science debates in the Canadian 2015 federal election, and my 4001st posting

Two things for me to celebrate today: Thanksgiving (in Canada, we celebrate on the 2nd Monday of October) and my 4001st posting (this one).

Science for the people

Plus, there’s much to celebrate about science discussion during the 2015 Canadian federal election. I stumbled across Science for the People, which is a weekly radio show based in Canada (from the About page),

Science for the People is a syndicated radio show and podcast that broadcasts weekly across North America. We are a long-format interview show that explores the connections between science, popular culture, history, and public policy, to help listeners understand the evidence and arguments behind what’s in the news and on the shelves.

Every week, our hosts sit down with science researchers, writers, authors, journalists, and experts to discuss science from the past, the science that affects our lives today, and how science might change our future.

Contact

If you have comments, show ideas, or questions about Science for the People, email feedback@scienceforthepeople.ca.

Theme Song

Our theme song music comes from the song “Binary Consequence” by the band Fractal Pattern. You can find the full version of it on their album No Hope But Mt. Hope.

License & Copyright

All Science for the People episodes are under the Creative Commons license. You are free to distribute unedited versions of the episodes for non-commercial purposes. If you would like to edit the episode please contact us.

Episode #338 (2015 Canadian federal election and science) was originally broadcast on Oct. 9,  2015 and features,

This week, we’re talking about politics, and the prospects for pro-science politicians, parties and voters in Canada. We’ll spend the hour with panelists Katie Gibbs, Executive Director of Evidence for Democracy, science librarian John Dupuis, journalist Mike De Souza, and former Canadian government scientist Steven Campana, for an in-depth discussion about the treatment of science by the current Canadian government, and what’s at stake for science in the upcoming federal election.

The podcast is approximately one hour long and Désirée Schell (sp?) hosts/moderates an interesting discussion where one of the participants notes that issues about science and science muzzles predate Harper. The speaker dates the issues back to the Chrétien/Martin years. Note: Jean Chrétien was Prime Minister from 1993 to 2003 and Paul Martin, his successor, was Prime Minister from 2003 to 2006 when he was succeeded by current Prime Minister, Stephen Harper. (I attended a Philosophers’ Cafe event on Oct. 1, 2015 where the moderator dated the issues back to the Mulroney years. Note: Brian Mulroney was Prime Minister from 1984 – 1993.) So, it’s been 10, 20, or 30 years depending on your viewpoint and when you started noticing (assuming you’re of an age to have noticed something happening 30 years ago).

The participants also spent some time discussing why Canadians would care about science. Interestingly, one of the speakers claimed the current Syrian refugee crisis has its roots in climate change, a science issue, and he noted the US Dept. of Defense views climate change as a threat multiplier. For anyone who doesn’t know, the US Dept. of Defense funds a lot of science research.

It’s a far ranging discussion, which doesn’t really touch on science as an election issue until some 40 mins. into the podcast.

One day later on Oct. 10, 2015 (where you’ll find the podcast), the Canadian Broadcasting Corporation’s Quirks & Quarks radio programme broadcast and made available its podcast of a 2015 Canadian election science debate/panel,

There is just over a week to go before Canadians head to the polls to elect a new government. But one topic that hasn’t received much attention on the campaign trail is science.

So we thought we’d gather together candidates from each of the major federal parties to talk about science and environmental issues in this election.

We asked each of them where they and their parties stood on federal funding of science; basic vs. applied research; the controversy around federal scientists being permitted to speak about their research, and how to cut greenhouse gas emissions while protecting jobs and the economy.

Our panel of candidates were:

– Lynne Quarmby, The Green Party candidate [and Green Party Science critic] in Burnaby North-Seymour, and  professor and Chair of the Department of Molecular Biology and Biochemistry at Simon Fraser University

– Gary Goodyear, Conservative Party candidate in Cambridge, Ontario, and former Minister of State for Science and Technology

– Marc Garneau, Liberal Party candidate in NDG-Westmount, and a former Canadian astronaut

– Megan Leslie, NDP candidate in Halifax and her party’s environment critic

It was a crackling debate. Gary Goodyear was the biggest surprise in that he was quite vigorous and informed in his defence of the government’s track record. Unfortunately, he was also quite patronizing.

The others didn’t seem to have as much information and data at their fingertips. Goodyear quote OECD reports of Canada doing well in the sciences and they didn’t have any statistics of their own to provide a counter argument. Quarmby, Garneau, and Leslie did at one time or another come back strongly on one point or another but none of them seriously damaged Goodyear’s defense. I can’t help wondering if Kennedy Stewart, NDP science critic, or Laurin Liu, NDP deputy science critic, and Ted Hsu, Liberal science critic might have been better choices for this debate.

The Quirks & Quarks debate was approximately 40 or 45 mins. with the remainder of the broadcast devoted to Canadian 2015 Nobel Prize winner in Physics, Arthur B. McDonald (Takaaki Kajita of the University of Tokyo shared the prize) for the discovery of neutrino oscillations, i.e., neutrinos have mass.

Kate Allen writing an Oct. 9, 2015 article for thestar.com got a preview of the pretaped debate and excerpted a few of the exchanges,

On science funding

Gary Goodyear: Currently, we spend more than twice what the Liberals spent in their last year. We have not cut science, and in fact our science budget this year is over $10 billion. But the strategy is rather simple. We are very strong in Canada on basic research. Where we fall down sometimes as compared to other countries is moving the knowledge that we discover in our laboratories out of the laboratory onto our factory floors where we can create jobs, and then off to the hospitals and living rooms of the world — which is how we make that home run. No longer is publishing an article the home run, as it once was.

Lynne Quarmby: I would take issue with the statement that science funding is robust in this country … The fact is that basic scientific research is at starvation levels. Truly fundamental research, without an obvious immediate application, is starving. And that is the research that is feeding the creativity — it’s the source of new ideas, and new understanding about the world, that ultimately feeds innovation.

If you’re looking for a good representation of the discussion and you don’t have time to listen to the podcast, Allen’s article is a good choice.

Finally, Research2Reality, a science outreach and communication project I profiled earlier in 2015 has produced an Oct. 9, 2015 election blog posting by Karyn Ho, which in addition to the usual ‘science is dying in Canada’ talk includes links to more information and to the official party platforms, as well as, an exhortation to get out there and vote.

Something seems to be in the air as voter turnout for the advance polls is somewhere from 24% to 34% higher than usual.

Happy Thanksgiving!

ETA Oct. 14, 2015:  There’s been some commentary about the Quirks & Quarks debate elsewhere. First, there’s David Bruggeman’s Oct. 13, 2015 post on his Pasco Phronesis blog (Note: Links have been removed),

Chalk it up to being a Yank who doesn’t give Canadian science policy his full attention, but one thing (among several) I learned from the recent Canadian cross-party science debate concerns open access policy.

As I haven’t posted anything on Canadian open access policies since 2010, clearly I need to catch up.  I am assuming Goodyear is referring to the Tri-Agency Open Access Policy, introduced in February by his successor as Minister of State for Science and Technology.  It applies to all grants issued from May 1, 2015 and forward (unless the work was already applicable to preexisting government open access policy), and applies most of the open access policy of the Canadian Institutes for Health Research (CIHR) to the other major granting agencies (the Natural Sciences and Engineering Research Council of Canada and the Social Sciences and Humanities Research Council of Canada).

The policy establishes that grantees must make research articles coming from their grants available free to the public within 12 months of publication. …

Then, there’s Michael Rennie, an Assistant Professor at Lakehead University and a former Canadian government scientist whose Oct. 14, 2015 posting on his unmuzzled science blog notes this,

This [Gary Goodyear’s debate presentation] pissed me off so much it made me come out of retirement on this blog.

Listening to Gary Goodyear (Conservative representative, and MP in Cambridge and former Minister of State for Science and Technology), I became furious with the level of misinformation given. …

Rennie went ahead and Storified the twitter responses to the Goodyear’s comments (Note: Links have been removed),

Here’s my Storify of tweets that help clarify a good deal of the misinformation Gary Goodyear presented during the debate, as well as some rebuttals from folks who are in the know: I was a Canadian Government Scientist with DFO [Department of Fisheries and Oceans] from 2010-2014, and was a Research Scientist at the Experimental Lakes Area [ELA], who heard about the announcement regarding the intention of the government to close the facility first-hand on the telephone at ELA.

Goodyear: “I was involved in that decision. With respect to the Experimental Lakes, we never said we would shut it down. We said that we wanted to transfer it to a facility that was better suited to operate it. And that’s exactly what we’ve done. Right now, DFO is up there undertaking some significant remediation effects to clean up those lakes that are contaminated by the science that’s been going on up there. We all hope these lakes will recover soon so that science and experimentation can continue but not under the federal envelope. So it’s secure and it’s misleading to suggest that we were trying to stop science there.”
There’s so many inaccuracies in here, it’s hard to know where to start. First, Goodyear’s assertion that there are “contaminated lakes” at ELA is nonsense. Experiments conducted there are done using environmentally-relevant exposures; in other words, what you’d see going on somewhere else on earth, and in every case, each lake has recovered to it’s natural state, simply by stopping the experiment.

Second, there ARE experiments going on at ELA currently, many of which I am involved in; the many tours, classes and researchers on site this year can attest to this.

Third, this “cleanup” that is ongoing is to clean up all the crap that was left behind by DFO staff during 40 years of experiments- wood debris, old gear, concrete, basically junk that was left on the shorelines of lakes. No “lake remediation” to speak of.

Fourth, the conservative government DID stop science at ELA- no new experiments were permitted to begin, even ones that were already funded and on the books like the nanosilver experiment which was halted until 2014, jeopardizing the futures the futures of many students involved. Only basic monitoring occurred between 2012-2014.

Last, the current government deserves very little credit for the transfer of ELA to another operator; the successful move was conceived and implemented largely by other people and organizations, and the attempts made by the government to try and move the facility to a university were met with incredulity by the deans and vice presidents invited to the discussion.

There’s a lot more and I strongly recommend reading Rennie’s Storify piece.

It was unfortunate that the representatives from the other parties were not able to seriously question Goodyear’s points.

Perhaps next time (fingers crossed), the representatives from the various parties will be better prepared. I’d also like to suggest that there be some commentary from experts afterwards in the same way the leaders’ debates are followed by commentary. And while I’m dreaming, maybe there could be an opportunity for phone-in or Twitter questions.

Science panel on CBC (radio) Quirks & Quarks plus more

Science panel or is it a debate?

Kudos to the Quirks & Quarks team for pulling together a science panel/debate on their CBC (Canadian Broadcasting Corporation) Radio One broadcast for the 2015 Canadian federal election. First, the tweet,

Many thanks for today’s election science panel: you were all great. Airs on Oct 10

Then, there’s the description from the Quirks & Quarks This week programme page,

This Week: Our All-Party Election Science Panel

Science and environmental issues have not been mentioned much in this long election campaign. So we thought we’d correct that by holding our own debate with candidates from all the major federal parties. [emphasis mine] We’ve gathered together:

– Lynne Quarmby, Green Party candidate in Burnaby-North, and  professor and Chair of the Department of Molecular Biology and Biochemistry at Simon Fraser University
– Gary Goodyear, Conservative Party candidate in Cambridge, Ontario, and former Minister of State for Science and Technology
– Marc Garneau, Liberal Party candidate in NDG-Westmount, and a former Canadian astronaut
– Megan Leslie, NDP candidate in Halifax and her party’s environment critic

The panel or debate will be broadcast on Saturday, Oct. 10, 2015 at 12 noon (rebroadcast on Monday, Oct. 12, 2015 at 11 pm and, in some markets, on Wednesday, Oct. 14, 2015 at 3 pm and made available at some point as a podcast). The panel/debate will be moderated by Bob McDonald, host for Quirks & Quarks, CBC Radio One.

I have a few comments about the panel. I’m surprised they didn’t mention that Lynne Quarmby is the Greens’ science shadow minister (also known as, the science policy critic); Marc Garneau once wrote his own Liberal science policy (mentioned in my Jan. 22, 2010 posting; scroll down about 50% of the way) when the Liberals were less interested in science although they did evince more interest by appointing Ted Hsu, a physicist and MP as their most recent science shadow minister [unfortunately he’s not running in this election]); I’m not familiar with Megan Leslie as Kennedy Stewart is the NDP’s science shadow minister; and Gary Goodyear in addition to being the former Minister of State for Science and Technology is a chiropractor known for his response to a question about evolution. It ran something along the lines of, “I don’t answer questions about my religion.” As the howling died down, he tried again with something like this, “Evolution is like having a pair of shoes that don’t fit. Over time your feet and/or the shoes adapt.” It’s not entirely wrong but it does leave out significant and important aspects of evolution as we currently understand it. In any event, muffled weeping could be heard across the nation. Those were his only serious missteps. Of course, most of his subsequent comments were scripted.

I trust it will be an interesting and dynamic discussion.

Science & Policy Exchange (SPE)/Dialogue sciences et politiques interviews

New post SPE Interviews Science and Technology Critic [Liberal] and Deputy Critic [NDP], Ted Hsu and Laurin Liu

Ted Hsu (Liberal shadow science minister)

Laurin Liu (NDP deputy shadow science minister)

For those interested in the Science & Policy Exchange, there’s more on their Who we are webpage,

We are a team of volunteer graduate students and post-doctoral fellows convinced that science and policy must communicate to better serve society. We aim to make this conference the premier forum for stakeholders to discuss the future of the knowledge economy in Quebec. Science & Policy Exchange is one of the few bilingual student led initiatives directly engaging Québec’s political scene and effectively bridging the gap between academia, industry and government leaders. If you are a student in the sciences and are interested in joining the conference organization committee or to volunteer for our organization please contact us.

The Science & Policy Exchange is a registered charity organization (Canada Revenue Agency) and listed in the Registraire des Entreprises du Québec.

also available in French

Based on the copyright notice at the bottom of the Who we are webpage, I believe this organization has been in place since 2010.

Final comments

It is exciting to see science becoming part of the election conversation. So, despite quibbles about who is or isn’t on the Quirks & Quarks science panel and the inability to phone in and ask questions along with the fear that ‘science muzzles’ will dominate discussion to the exclusion of much else, this panel and the SPE interviews are a huge step forward and kudos are owed to all involved.

Updates on a Canadian election science debate and the 2015 Canadian Science Policy Conference (blog session) plus a protest song

I have some good news on a couple of fronts. First, it seems increasingly likely that we will see a 2015 election science debate.

Canadian election 2015 science debate

The debate will be, according to Jim Handman, senior producer, held in early October 2015 on CBC (Canadian Broadcasting Corporation) radio’s Quirks and Quarks program. Here’s what Mr. Handman had to say after I tweeted and contacted them about holding an election science debate,

… Quirks has approached all the parties at the national
level to provide candidates for a radio panel on science to be
broadcast in early October. They have all expressed interest and we are waiting to hear about specific candidates. It is up to the parties to choose the participants.

Not realizing something was in the works at Quirks and Quarks and following on a suggestion from David Bruggeman at Pasco Phronesis (noted in my Aug. 17, 2015 posting), I contacted Lynne Quarmby (Green shadow science minister), Ted Hsu (Liberal shadow science minister), Kennedy Stewart (NDP [New Democratic Party] shadow science minister), and Ed Holder (Conservative science minister) about their willingness to participate in a debate. As of this writing, both Lynne Quarmby and Ted Hsu have shown interest.

While I was busy tweeting, this was brought to my attention,

UVic2015electonScienceDebate

You can see, if you look carefully at the bottom of the poster, the Evidence for Democracy logo. Those folks kicked off a proposal for science debate for this election in an Aug. 12, 2015 opinion piece for the Toronto Star.

Plus, CBC is reporting a new call for a science debate in a Sept. 3, 2015 news item by Julie Ireton,

Members of Canada’s long-silent scientific research community are increasingly speaking out during this year’s federal campaign as they desperately try to make science an election issue.

Jules  Blais, a biology professor at the University of Ottawa, calls cuts to science-related jobs “targeted strikes.”

Like many Canadian scientists, Blais considers himself non-partisan and said he’s not campaigning for any particular party, but that he and others are speaking out for the need to protect independent scientific research.

“Science has always been apolitical by its nature, but in recent years because of the dramatic changes that we’re seeing in the way science is being done, and science is being conducted, it’s increasingly a political issue,” said Blais.

To sum it up, it all looks quite promising for 2015 although I hope any national debate will be more broad-ranging and nuanced than a simple Conservative science policy bashing.

For anyone interested in ancient history, there’s my Aug. 17, 2015 posting which provides a view of previous efforts to get a science debate during an election in English-speaking Canada and notes like efforts have taken place in French-speaking Canada. Happily for anyone wanting a more complete history, Pascal Lapointe and Josh Silberg have written an Aug. 31, 2015 posting on Science Borealis detailing efforts in Québec.

Canadian Science Policy Conference blogging session

In an Aug. 18, 2015 posting, I highlighted and critiqued the blogging session offered at the upcoming 2015 Canadian Science Policy Conference. One of the blog panel members, Chris Buddle kindly contacted me via Twitter to answer a few of the questions I’d posed and to tell me that he’d contacted the organizers and suggested some changes be made to the descriptions based on my comments. You can find the changed descriptions here.

They’ve added one person to the panel, Lisa Willemse, who’s billed as Senior Communications Advisor, Ontario Institute for Regenerative Medicine.

One final comment about the science blogging panel descriptions, I wish they’d added links to the blogs. Perhaps that wasn’t technical feasible?

Protest song

Part of what has mobilized scientists and a discussion of science in Canada has been the Conservative government’s policy of ‘muzzling scientists’. Glyn Moody in a Sept. 1, 2015 posting on Techdirt profiles an incident where Environment Canada scientist, Tony Turner, has been put on leave while charges that he violated conflict-of-interest rules are being investigated. His sin: he wrote a protest song, got a group of friends and supporters to sing it with him, and then posted it to Youtube. From Moody’s posting (Note: A link has been removed),

Turner’s song, with its opening lines “Who controls our parliament? Harperman, Harperman. Who squashes all dissent? Harperman, Harperman,” and a refrain of “It’s time for you to go,” is pretty mild stuff. …

Of course, the great thing about the Canadian government’s absurd overreaction to this gentlest of private protests is that many more people will now learn that Turner is an environmental scientist who is being muzzled by a bunch of desperate control freaks who are frightened that the Canadian people might be told the truth about important scientific issues. Thank goodness for the Streisand Effect…. [As I understand it, Barbra Streisand once responded to criticism or commentary about herself that she found offensive. Her response, given her star power, drew a great of attention to the commentary. Techdirt folks have dubbed this the ‘Streisand’ effect, i.e. drawing attention to something no one would have noticed otherwise.]

An Aug. 28, 2015 article by Madeline Smith for the Globe and Mail provides details about the protest song and government response,

An Environment Canada scientist is under investigation for allegedly breaching the public service code of ethics by writing and performing a political song that criticizes the Harper government.

Andrew Hall, who filmed the Harperman video – a singalong with a backup choir that had almost 60,000 views as of Friday [Aug. 28, 2015] evening – said the song is a “joyful” expression of protest. [emphasis mine] He said Mr. Turner wasn’t acting as a public servant, so there should be a reasonable expectation “to be able to engage in democracy.”

As of Thurs., Sept. 3, 2015 at 10 am PDT the number of views is 525,823. So, from June 2015 when it was first posted to Aug. 28, 2015, there were almost 60,000 views. The Streisand effect in operation!

According to Smith’s article, Turner, after working for the government for 20 years, is months from retirement.

Finally, the song,

Rousing, isn’t it? That said, there is a fine line to be tread here. Civil servants are required to be neutral and, assuming you’re not dealing with noxious forces, you need to be respectful of the agreements you’ve made. As a civil servant for a number of years, that freedom of speech vs. neutrality ethics divide always bothered me. I believe that people are entitled to speak their opinions in private but I do see the point of insisting on neutrality professionally and privately. Most times, neutrality is the way to go for civil servants. However, there are times when one must speak out. The question is: what is the tipping point?

ETA Sept. 4, 2015: In the US they’re having their own civil servant neutrality issues. As evidenced by this story of the Kentucky clerk who refuses to issue marriage licences to same sex couples, civil service neutrality is not an open and shut discussion. Note: Slate has adopted a policy of urging readers to subscribe with popup ads.

Creating Connections; a conference at the University of British Columbia (Canada) for women in science, engineering, and technology

The conference, Creating Connections, is coming up shortly, May 10 and 11, 2013 at the University of British Columbia (Canada). The deadline for registration is May 5, 2013. Here’s more about the conference, from the conference webpage,

Please join us at Creating Connections, a conference for supporting and enabling a meaningful dialogue about the participation of women in Science, Engineering and Technology.

Keynote features:

  • Friday public keynote: The Role of Gender in Science Communication panel discussion, with Moderator Dr. Jennifer Gardy (Senior Scientist, BC Centre for Disease Control, and recurring guest host for Daily Planet on the Discovery Channel) and panelists:
    • Bob McDonald (Host of CBC Radio One’s Quirks and Quarks);
    • Dr. Carin Bondar (Host for Discovery International and blogger for Scientific American); and
    • Cam Cronin (Public Programmer, HR MacMillan Space Centre).
  • Dr. Roberta Bondar (the world’s first neurolgist in space and Canada’s first female astronaut).
  • Anna Tudela (Vice-President of Regulatory Affairs and Corporate Secretary, Goldcorp Inc.).
  • Dr. Amiee Chan (CEO, Norsat).

Other Highlights:

  • Conference session topics include Entrepreneurship, Job Searching (Academic and Industrial), Mentorship, Work/Life Balance, and Networking
  • Conference presenters include company CEOs and managers, university professors, and career coaches.

Creating Connections: Working Together to Transform Our World will bring together over 250 people for a full day of personal and professional development, networking, and inspiration. By supporting and enabling a meaningful dialogue about the participation of women in Science, Engineering, and Technology (SET), we build capacity for individuals and organizations to engage in transformative and long-lasting change. We will create a place where everyone can belong.

Creating Connections is for everyone who wants to engage in a dialogue about diversity in SET disciplines: men and women, students, industry professionals, academics, people in career transition, managers and HR professionals, and people from the wider community. Our discussion will be broad, and topics will be applicable to more than one situation or group.

There’s more detail about the conference including costs on the registration page.

2012 Canadian science blog roundup and some thoughts on a Canadian science blog network

This is my 3rd annual roundup of Canadian science blogs and the science blogging scene in Canada seems to be getting more lively (see my Dec. 31, 2010 posting and Dec. 29, 2011 posting to compare).

As I did last year, I will start with

Goodbyes

Don’t leave Canada appears to be gone as there hasn’t been posting there since May 4, 2011. I’m sorry to see it go as Rob Annan provided thoughtful commentary on science policy on a regular basis for years. Thank you, Rob. (BTW, he’s now the director of policy, research and evaluation at MITACS.)

Cool Science, John McKay’s blog has been shut down as of Oct. 24, 2012,

Hi everyone. This will mark the final post of the CoolScience.ca site and it will be quietly taken offline in November. I will also be closing down the Twitter and Facebook accounts and moving everything over to my professional accounts that are all focused on communicating science, technology, engineering and medicine.

The Dark Matter science blog by Tom Spears, which I reluctantly (as it was a ‘newspaper blog’ from the Ottawa Citizen)included last year  has since disappeared as has NeuroDojo, a blog written by a Canadian scientist in Texas.

Goodbye ish

Marc Leger’s Atoms and Numbers blog’s latest posting is dated Oct. 23, 2012 but the pattern here seems similar to Marie-Claire’s (see the next one) where the posting is erratic but relatively regular (once or twice per month) until October of this year.

Marie-Claire Shanahan is posting less frequently on her Boundary Vision blog with the last posting there on Oct. 9, 2012.

The Bubble Chamber blog from the University of Toronto’s Science Policy Work Group seems to be fading away with only one posting for 2012, Reply to Wayne Myrvold on the Higgs Boson.

Colin Schulz’s CMBR blog hasn’t had a new posting since July 13, 2012’s 11 Things You Didn’t Know About Canada. In any event, it looks like the blog is no longer primarily focused on science.

The Exponential Book blog by Massimo Boninsegni features an Oct. 24, 2012 posting and a similar posting pattern to Marie-Claire & Marc.

exposure/effect which was new last year has gone into a fairly lengthy hiatus as per its last post in January 30, 2012 posting.

Theoretical biologist, Mario Pineda-Krch of Mario’s Entangled Bank blog is also taking a lengthy hiatus as the last posting on that blog was June 11, 2012.

Nicole Arbour’s Canadian science blog for the UK High Commission in Ottawa hasn’t featured a posting since Oct. 15, 2012’s The Power of We: Adapting to climate change.

Gregor Wolbring’s Nano and Nano- Bio, Info, Cogno, Neuro, Synbio, Geo, Chem… features an Aug. 4, 2012 posting which links to one of his nano articles, (Nanoscale Science and Technology and People with Disabilities in Asia: An Ability Expectation Analysis) published elsewhere.

Jeff Sharom’s Science Canada blog highlights links to editorials and articles on Canadian science policy but doesn’t seem to feature original writing by Sharom or anyone else, consequently, it functions more as a reader/aggregator than a blog.

The Black Hole blog which was always more focused on prospect for Canadian science graduates than Canadian science, hence always a bit of a stretch for inclusion here, has moved to the University Affairs website where it focuses more exclusively on the Canadian academic scene with posts such as this, Free journal access for postdocs in between positions  from Dec. 12, 2012.

Returning to the roundup:

John Dupuis’ Confessions of a Science Librarian whose Dec. 26, 2012 posting, Best Science (Fiction) Books 2012: io9 seems timely for anyone taking a break at this time of year and looking for some reading material.

Daniel Lemire’s blog is known simply as Daniel Lemire. He’s a computer scientist in Montréal who writes one of the more technical blogs I’ve come across and his focus seems to be databases although his Dec. 10, 2012 posting covers the topic of how to get things accomplished when you’re already busy.

Dave Ng, a professor with the Michael Smith Laboratories at the University of British Columbia, is a very active science communicator who maintain the Popperfont blog. The latest posting (Dec. 24, 2012) features Sciencegeek Advent Calendar Extravaganza! – Day 24.

Eric Michael Johnson continues with his The Primate Diaries blog on the Scientific American blog network. His Dec. 6, 2012 posting is a reposted article but he has kept up a regular (once per month, more or less) posting schedule,

Author’s Note: The following originally appeared at ScienceBlogs.com and was subsequently a finalist in the 3 Quarks Daily Science Prize judged by Richard Dawkins. Fairness is the basis of the social contract. As citizens we expect that when we contribute our fair share we should receive our just reward. When social benefits are handed out …

Rosie Redfield is keeping with both her blogs, RRTeaching (latest posting, Dec. 6, 2012) and RRResearch (Nov. 17, 2012).

Sci/Why is a science blog being written by Canadian children’s writers who discuss science, words, and the eternal question – why?

Mathematician Nassif Ghoussoub’s Piece of Mind blog continues to feature incisive writing about science, science funding, policy and academe.

Canadian science writer Heather Pringle continues to post on the The Last Word on Nothing, a blog shared collectively by a number of well known science writers. Her next posting is scheduled for Jan. 3, 2013, according to the notice on the blog.

A little off my usual beat but I included these last year as they do write about science albeit medical and/or health science:

Susan Baxter’s blog Curmudgeon’s Corner features her insights into various medical matters, for example there’s her Dec. 1, 2012 posting on stress, the immune system, and the French antipathy towards capitalism.

Peter Janiszewski and Travis Saunders co-own two different blogs, Obesity Panacea, which is part of the PLoS (Public Library of Science) blogs network, and Science of Blogging which features very occasional posting but it’s worth a look for nuggets like this Oct. 12, 2012 (?) posting on social media for scientists.

After posting the 2011 roundup,

I had a number of suggestions for more Canadian science blogs such as these four who are part of the Scientific American SA) blogging network (in common with Eric Michael Johnson),

Dr. Carin Bondar posts on the SA blog, PsiVid, along with Joanne Manaster. There’s more than one Canadian science blogger who co-writes a blog. This one is self-described as, A cross section of science on the cyberscreen.

Glendon Mellow, a professional science illustrator,  posts on The Flying Trilobite (his own blog) and Symbiartic: the art of science and the science of art, an SA blog he shares with Kalliopi Monoyios.

Larry Moran, a biochemist at the University of Toronto, posts on science and anything else that tickles his fancy on his Sandwalk blog.

Eva Amsen who posts on a number of blogs including the NODE; the community site for developmental biologists  (which she also manages) but the best place to find a listing of her many blogs and interests is at easternblot.net, where she includes this self-description on the About page,

Online Projects

  • Musicians and Scientists – Why are so many people involved in both music and science? I’m on a mission to find out.
  • the NodeMy day job is managing a community site for developmental biologists around the world. The site is used by equal numbers of postdocs, PhD students, and lab heads.
  • SciBarCamp/SciBarCamb – I co-instigated SciBarCamp, an unconference for scientists, in Toronto in 2008. Since then I have co-organized five similar events in three countries, and have advised others on how to run science unconferences.
  • You Learn Something New Every Day – a Tumblr site that automatically aggregates tweets with the hashtag #ylsned, and Flickr photos tagged ylsned, to collect the interesting bits of trivia that people come across on a daily basis.
  • Lab Waste – During my last months in the lab as a PhD student, I made a mini-documentary (using CC-licensed materials) about the excessive amount of disposable plastics used in research labs. It screened in 2009 in the “Quirky Shorts” program of the Imagine Science Film Festival in New York.
  • Expression Patterns – In 2007 I was invited to blog on Nature Network. The complete archives from 2007-2012 are now on this site.
  • easternblot.net – Confusingly, my other science blog was named after this entire domain. It ran from 2005 to 2010, and can be found at science.easternblot.net

I believe Amsen is Canadian and working in the UK but if anyone could confirm, I would be much relieved.

Someone, who according to their About page prefers to remain anonymous but lives in Victoria, BC, and posts (somewhat irregularly, the last posting is dated Nov. 10, 2012) on The Olive Ridley Crawl,

I am an environmental scientist blogging about environmental and development issues that interest me. I prefer to be anonymous(e) because I work with some of the companies I may talk about and I want to avoid conflict of interest issues at work. This gets tricky because I am at the periphery of a lot of events happening in the world of my greatest expertise, persistent organic pollutants, endocrine disrupting compounds, their effects on health and the policy fights around chemicals, their use the controversies! So, I’ve reluctantly moved away from writing about what I know most about, which means this blog suffers severely. I still soldier on, though!

I was born, and grew up in India, so I am interested in all things South Asian and tend to view most all Western government and Western institution actions through a colonialist scratched lens! I am also becoming much more active about my feminism, so who knows what that will do to this blog. I have been meaning to write a monstrous essay about women, the environment and justice, but that’s a task!

I used to live in Chapel Hill, NC with a partner of long vintage (the partnership, that is, not her!) and a crazy cat who thinks he’s a dog. We moved to Victoria, BC in 2008 and I’ve been busy learning about Canadian policy, enjoying this most beautiful town I live in.

Why Olive Ridley? Well, the Olive Ridley sea turtle (Lepidochelys Olivacea) nests on the coasts of Madras, India and I got my start in the wonderful world of conservation working on the Olive Ridley with the Students’ Sea Turtle Conservation Network. So, I do have fond memories for this beautiful creature. And yes, as my dear partner reminds me, I did meet her on the beach when I was doing this work.

Agence Science-Presse (based in Québec and headed by Pascal Lapointe) features three blogs of its own:

Blogue ta science : les billets dédiés aux jeunes.

Discutez avec notre expert : avez-vous suivi notre enquête CSI ?

Autour des Blogues : les actualités de nos blogueurs et de la communauté.

There’s also a regular podcast under the Je vote pour la science banner.

genegeek appears to be Canadian (it has a domain in Canada) but the blog owner doesn’t really identify herself (there’s a photo) on the About page but no name and no biographical details. I did receive a tweet last year about genegeek from C. Anderson who I imagine is the blog owner.

There’s also the Canadian BioTechnologist2.0 blog, which is sponsored by Bio-Rad Canada and is written by an employee.

These next ones were added later in the year:

Chuck Black writes two blogs as he noted in June 2012,

I write two blogs which, while they focus more on space than science, do possess strong science components and overlap with some of the other blogs here.

They are: Commercial Space and Space Conference News.

Andy Park also came to my attention in June 2012. He writes the  It’s the Ecology, Stupid! blog.

Something About Science is a blog I featured in an Aug. 17, 2012 posting and I’m glad to see blogger, Lynn K, is still blogging.

New to the roundup in 2012:

SSChow, Sarah Chow’s blog, focuses on science events in Vancouver (Canada) and science events at the University of British Columbia and miscellaneous matters pertinent to her many science communication efforts.

The Canadian federal government seems to be trying its hand at science blogging with the Science.gc.ca Blogs (http://www.science.gc.ca/Blogs-WSE6EBB690-1_En.htm). An anemic effort given that boasts a total of six (or perhaps it’s five) posting in two or three years.

The Canadian Science Writers Association (CSWA) currently features a blog roll of its members’ blogs. This is a new initiative from the association and one I’m glad to see.  Here’s the list (from the CSWA member blog page),

Anne Steinø (Research Through the Eyes of a Biochemist)
Arielle Duhame-Ross (Salamander Hours)
Bob McDonald (I’m choking on this one since it’s a CBC [Canadian Broadcasting Corporation] blog for its Quirks and Quarks science pr0gram)
Cadell Last (The Ratchet)
Edward Willett
Elizabeth Howell (she seems to be blogging again and the easiest way for me to get to her postings was to click on the Archives link [I clicked on December 2012 to get the latest] after doing that I realized that the images on the page link to postings)
Heather Maughan
Justin Joschko
Kimberly Gerson (Endless Forms Most Beautiful)
Mark Green (a CSWA member, he was born and educated in the US where he lives and works; ordinarily I would not include him, even with his  CSWA membership status,  but he writes a monthly science column for a Cape Breton newspaper, which has made me pause)
Pamela Lincez (For the Love of Science)
Sarah Boon (Watershed Moments)
Susan Eaton (she seems to be reposting articles written [presumably by her] for the AAPG [American Association of Petroleum Geologists] Explorer and other organizations in her blog]

Barry Shell’s site (listed as a CSWA member blog) doesn’t match my admittedly foggy notion of a blog. It seems more of an all round Canadian science resource featuring profiles of Canadian scientists, a regularly updated news archive, and more. Science.ca is extraordinary and I’m thankful to have finally stumbled across it but it doesn’t feature dated posts in common with the other blogs listed here, even the most commercial ones.

Tyler Irving (I had no idea he had his own blog when I mentioned him in my Sept. 25, 2012 posting about Canadian chemists and the Canadian Chemical Institute’s publications) posts at the Scientific Canadian.

I choke again, as I do when mentioning blogs that are corporate media blogs, but in the interest of being as complete as possible Julia Belluz writes the Scien-ish blog about health for MacLean’s magazine.

Genome Alberta hosts a couple of blogs: Genomics and Livestock News & Views.

Occam’s Typewriter is an informal network of science bloggers two of whom are Canadian:

Cath Ennis (VWXYNot?) and Richard Wintle (Adventures in Wonderland). Note: The Guardian Science Blogs network seems to have some sort of relationship with Occam’s Typewriter as you will see postings from the Occam’s network featured as part of Occam’s Corner on the Guardian website.

My last blogger in this posting is James Colliander from the University of  Toronto’s Mathematics Department. He and Nassif (Piece of Mind blog mentioned previously) seem to share a similar interest in science policy and funding issues.

ETA Jan.2.13: This is a social science oriented blog maintained by a SSHRC- (Social Science and Humanities Research Council) funded network cluster called the Situating Science Cluster and the blog’s official name is: Cluster Blog. This is where you go to find out about Science and Technology Studies (STS) and History of Science Studies, etc. and events associated with those studies.

I probably should have started with this definition of a Canadian blogger, from the Wikipedia entry,

A Canadian blogger is the author of a weblog who lives in Canada, has Canadian citizenship, or writes primarily on Canadian subjects. One could also be considered a Canadian blogger if one has a significant Canadian connection, though this is debatable.

Given how lively the Canadian science blogging scene has become, I’m not sure I can continue with these roundups as they take more time each year.  At the very least, I’ll need to define the term Canadian Science blogger, in the hope of reducing the workload,  if I decide to continue after this year.

There’s a rather interesting Nov. 26, 2012 article by Stephanie Taylor for McGill Daily about the Canadian public’s science awareness and a dearth of Canadian science communication,

Much of the science media that Canadians consume and have access to is either American or British: both nations have a robust, highly visible science media sector. While most Canadians wouldn’t look primarily to American journalism for political news and analysis, science doesn’t have the same inherent national boundaries that politics does. While the laws of physics don’t change depending on which side of the Atlantic you’re on, there are scientific endeavours that are important to Canadians but have little importance to other nations. It’s unlikely that a British researcher would investigate the state of the Canadian cod fishery, or that the British press would cover it, but that research is critical to a substantial number of Canadians’ livelihoods.

On the other hand, as Canadian traditional media struggles to consistently cover science news, there’s been an explosion of scientists of all stripes doing a lot of the necessary big picture, broad context, critical analysis on the internet. The lack of space restrictions and accessibility of the internet (it’s much easier to start a blog than try to break in to traditional media) mean that two of the major barriers to complex discussion of science in the media are gone. Blogs struggle to have the same reach as newspapers and traditional media, though, and many of the most successful science blogs are under the online umbrella of mainstream outlets like Scientific American and Discover. Unfortunately and perhaps unsurprisingly, there is currently no Canadian science blog network like this. [emphasis mine]

Yes, let’s create a Canadian science blog network. I having been talking to various individuals about this over the last year (2012) and while there’s interest, someone offered to help and then changed their mind. Plus, I was hoping to persuade the the Canadian Science Writers Association to take it on but I think they were too far advanced in their planning for a member’s network to consider something more generalized (and far more expensive). So, if anyone out there has ideas about how to do this, please do comment and perhaps we can get something launched in 2013.