Tag Archives: Canadian Light Source (CLS)

Key to developing stronger, ‘greener’ adhesives: fresh water oysters

A September 17, 2024 news item on phys.org highlights some research on creating ‘green’, i.e., environmentally friendly, glue,

Freshwater oysters produce an adhesive that may hold the secret to developing more environmentally friendly glues with applications from dental care to construction and shipping. An international research team recently used the Canadian Light Source (CLS) at the University of Saskatchewan (USask [Canada]) to determine what the unique adhesive is made of.

Thriving in African rivers and lakes, Etheria elliptica oysters produce a special material that helps them stick to wood or other oysters, creating complex underwater reefs. Never studied before, this oyster glue has characteristics rarely found in similar organisms: it’s made of a mineral called aragonite that the oyster arranges so that it is soft on the outside and progressively harder on the inside.

A September 17, 2024 Canadian Light Source (CLS) news release (also received via email) by Federica Gianelli provides more detail about the research,

“These oyster shells aren’t exactly like our teeth and our bones, but there are a lot of similarities,” says Rebecca Metzler, professor of physics at Colgate University in New York State. “And so, if the adhesive can work for the oyster shell, maybe it could work pretty well for what’s happening inside of us.”

Metzler and her team found that the oyster glue is so sticky because it combines the aragonite with special proteins that the oyster produces. This information could pave the way for the development of better synthetic, “green” glues that mimic the properties of the oyster’s adhesive.

“Because I’m looking at this biological tissue, I need a certain energy range, and the Canadian Light Source has that sweet spot of having both the microscope and the energy range,” says Metzler. “You can look at your sample, get the spectral data that you need to be able to answer questions about what is this made up of, and how these things are structured.”

Her team discovered that the oyster glue is made up of tiny particles of aragonite that clump together into crystals of random shapes, sizes and orientation, information, says Metzler, that can be used to create synthetic versions in a lab. This research, which also relied on data gathered at the Advanced Light Source (ALS) synchrotron [located at the Lawrence Berkeley National Laboratory in California, US] , is published in the journal Advanced Materials Interfaces.

What they’ve learned could have multiple applications, Metzler says. Glues synthesized from the oyster’s adhesive could be used to bind dental implants, replace glues currently used in the packaging industry with bio-degradable alternatives, or even build structures underwater.

Metzler’s research may also prove critical for the ecological conservation of Etheria elliptica oysters. With freshwater mussel populations declining globally, understanding how these organisms create underwater reefs is key to preserving habitats that ensure the oysters’ survival in a warming climate, as well as informing local populations about sustainable oyster harvesting.

Because the oysters used in Metzler’s study were collected years ago, a next step will be investigating the impact of climate change on more recent samples.

“Whether there’s been a change similar to what we’re seeing in other organisms, that would be another thing we’d be interested in trying to figure out.”

Here’s a link to and a citation for the paper,

Exploring the Mineral Composition, Structure, and Function of a Freshwater Bivalve Adhesive by Rebecca A. Metzler, Julia Zaborowsky, Leon Nichols, Jack Underhill, Jack Tregidga, Chelsea Rogers, Deniz Rende, Steven Bouillon, David P. Gillikin. Advanced Materials Interfaces Volume 11, Issue 17 June 17, 2024 2300954 DOI: https://doi.org/10.1002/admi.202300954 First published online: 03 May 2024

This paper is open access.

Rare earth elements (REE) and the Canadian Light Source

Unexpectedly, this story centers on coal and in this case, coal ash. A September 12, 2024 Canadian Light Source news release (also received via email)) by Brian Owens explains how coal ash is a source for rare earth elements (RRE), Note: A link has been removed,

As the world transitions away from fossil fuels, the demand for rare earth elements (REEs) is only going to increase. These elements are vital to the production of technologies that will make the transition to green energy possible. While REEs are not technically rare, large deposits are found in only a few locations around the world – mostly in China – and they are difficult to extract.

“If we want to switch to electric vehicles by 2035 and be net-zero by 2050 we’re going to need new sources of these metals,” says Brendan Bishop, a PhD candidate studying REEs at the University of Regina.

Bishop and his colleagues have been studying one potential new source of these valuable elements: the ash that is produced as waste from coal-fired power plants. Researchers have looked into REEs in coal waste in the United States and China, but there has been little work done on ash from Canadian coal.

The team analyzed samples of ash from coal plants in Alberta and Saskatchewan to determine how much REEs the ashes contained, and how they could be extracted. While the concentration of REEs in Canadian coal ash is on par with that found in ash from other parts of the world, questions remained about whether the REEs are dispersed evenly throughout the ash particles or concentrated in certain minerals found within the ashes.

Using the powerful X-ray beamlines at the Canadian Light Source (CLS) at the University of Saskatchewan (USask), Bishop probed the ash, in search of a rare earth element called yttrium. They found it was distributed in specific mineral phases within the ash particles, most often in the form of silicates or phosphates such as xenotime which remain unchanged when the coal is burned.  The work was published in Environmental Science and Technology.

Bishop says this data can help inform development of an efficient and environmentally friendly process for recovering REEs from the ash. “This will be important when we develop a recovery process because extracting rare earth elements is technologically challenging,” he says. “In this case, since it’s in xenotime which is an ore mineral, maybe we can use an existing process and modify it for coal ash.”

The amount of REEs that could be extracted from coal ash will depend on the recovery process, says Bishop. But he thinks it could be a good short-to-medium-term source of the metals. The concentration is not particularly high, but that is offset by the fact that waste coal ash is plentiful. The concentration throughout the ash is also fairly homogenous, so no complicated grading is required as with mined ores. Once the extraction process is perfected, it will also be much faster than opening new mines, which often have gaps of up to 17 years between exploration and production.

Recovering REEs from the ash is also an important step toward a circular economy. Some ash is used in making concrete, but most just sits in landfills or tailings ponds near power plants. “It not only gets rid of an environmental liability, but it also gives us the metals we need for clean energy technologies,” says Bishop.

Here’s a link to and a citation for the paper,

Rare Earth Element Speciation in Coal and Coal Combustion Byproducts: A XANES and EXAFS Study by Brendan A. Bishop, Karthik Ramachandran Shivakumar, Jamie Schmidt, Ning Chen, Daniel S. Alessi, Leslie J. Robbins. Environ. Sci. Technol. 2024, 58, 32, 14565–14574 Published July 30, 2024 DOI: https://doi.org/10.1021/acs.est.4c04256 Copyright © 2024 American Chemical Society

This paper is behind a paywall.

Seeing signs of osteoarthritis before joint replacements necessary

A November 29, 2024 Canadian Light Source (CLS) news release (also received via email) by Brian Owens describes research that could benefit people who don’t know they have the beginning signs of osteoarthritis,

An imaging technique currently available only at synchrotrons like the Canadian Light Source at the University of Saskatchewan (USask) could one day enable doctors to detect osteoarthritis while patients can still be treated with medication – before they require joint replacement — thanks to research by USask scientist Brian Eames and colleagues.

In a pair of studies, Eames, a professor of Anatomy, Physiology, and Pharmacology in the USask College of Medicine, found that phase contrast imaging (PCI) detects very subtle changes in cartilage. He says the technique, which takes advantage of the high-energy light produced by the synchrotron, provides “fantastic” imaging of cartilage.

In the most recent study, Eames and colleagues (Daniel Chen, College of Engineering; Ali Honoramooz, Western College of Veterinary Medicine; Bill Dust, College of Medicine; and PhD student Hamed Alizadeh) used PCI to determine how well 3D-bioprinted cartilage could repair damaged joints. They compared the performance of cells impregnated in two different materials – one a squishy material called hydrogel and the other a hybrid construct combining hydrogel with a stiff plastic material. They hypothesized that the hybrid construct would shield the cells from forces in the recovering joint, so that the proper type of cartilage (hyaline) could form.

When they implanted these materials into animal joints, the researchers found that both helped new cartilage form, with the hydrogel doing slightly better by some measures. The hybrid, however, had one advantage: It formed less fibrocartilage, which was consistent with the team’s hypothesis. Fibrocartilage is a tougher form of cartilage that is created when joints are under stress. Having less fibrocartilage provides better joint function.

In an earlier study, Eames found that the superior resolution of PCI enabled more precise mapping of the articular cartilage surface than MRI – currently the “go to” imaging technique for osteoarthritis

Eames says that, while both sets of results are interesting, he’s more excited about the potential they hint at for bringing PCI into the clinical setting. PCI’s precision and ability to detect subtle changes “might be able to increase the ability to detect osteoarthritis earlier than regular clinical monitoring,” giving doctors more options for early treatment and researchers potential new targets for drug development.

While a football-field-sized synchrotron will never be a standard part of a hospital imaging suite, Eames says some companies are already working on ways to adapt the technology to make it portable for clinical use.

“The [CLS] is a nice test case for the technology that others can try to adapt for clinical use in humans,” he says.

Eames is seen discussing the work in this video,

Here are links to both papers mentioned in the news release, with the most recent work being first,

Comparison study on hyaline cartilage versus fibrocartilage formation in a pig model by using 3D-bioprinted hydrogel and hybrid constructs by Hamed Alizadeh Sardroud, Gustavo Dos Santos Rosa, William Dust, Tat-Chuan Cham, Gwen Roy, Sarah Bater, Alan Chicoine, Ali Honaramooz, Xiongbiao Chen and B Frank Eames. Biofabrication, 015014 Volume 17, Number 1 DOI 10.1088/1758-5090/ad88a6 Published 5 November 2024 • © 2024 The Author(s). Published by IOP Publishing Ltd

This paper is open access.

MRI overestimates articular cartilage thickness and volume compared to synchrotron radiation phase-contrast imaging by Suranjan Bairagi, Mohammad-Amin Abdollahifar, Oghenevwogaga J. Atake, William Dust, Sheldon Wiebe, George Belev, L. Dean Chapman, M. Adam Webb, Ning Zhu, David M. L. Cooper, B. Frank Eames. PLOS DOI: https://doi.org/10.1371/journal.pone.0291757 Published: October 3, 2023

This paper is open access.

The 2024 Canadian federal budget: some thoughts on science & technology, military, and cybersecurity spending

The 2024 Canadian federal budget – Fairness for Every Generation (or if you want to see the front page, Budget 2024 – Fairness for Every Generation and then go to Go View the Budget for the table of contents) was announced in April 2024. So, I’m very late with this posting.

There weren’t too many highlights in the 2024 budget as far as I was concerned. Overall, it was a bread and butter budget concerned with housing, jobs, business, and prices along with the government’s perennial focus on climate change and the future for young people and Indigenous peoples. There was nothing particularly special about the funds allocated for research and, as for defence spending in the 2024 budget, that was and is nominally interesting.

“Boosting Research, Innovation, and Productivity” was found in Chapter Four: Economic Growth for Every Generation.

4.1 Boosting Research, Innovation, and Productivity

For anyone who’s not familiar with ‘innovation’ as a buzzword, it’s code for ‘business’. From 4.1 of the budget,

Key Ongoing Actions

  • Supporting scientific discovery, developing Canadian research talent, and attracting top researchers from around the planet to make Canada their home base for their important work with more than $16 billion committed since 2016.
  • Supporting critical emerging sectors, through initiatives like the Pan-Canadian Artificial Intelligence Strategy, [emphases mine] the National Quantum Strategy, the Pan-Canadian Genomics Strategy, and the Biomanufacturing and Life Sciences Strategy.
  • Nearly $2 billion to fuel Canada’s Global Innovation Clusters to grow these innovation ecosystems, promote commercialization, support intellectual property creation and retention, and scale Canadian businesses.
  • Investing $3.5 billion in the Sustainable Canadian Agricultural Partnership to strengthen the innovation, competitiveness, and resiliency of the agriculture and agri-food sector.
  • Flowing up to $333 million over the next decade to support dairy sector investments in research, product and market development, and processing capacity for solids non-fat, thus increasing its competitiveness and productivity.

The only ’emerging’ sector singled out for new funding was the Pan-Canadian Artificial Intelligence Strategy and that is almost all ‘innovation’, from 4.1 of the budget,

Strengthening Canada’s AI Advantage

Canada’s artificial intelligence (AI) ecosystem is among the best in the world. Since 2017, the government has invested over $2 billion towards AI in Canada. Fuelled by those investments, Canada is globally recognized for strong AI talent, research, and its AI sector.

Today, Canada’s AI sector is ranked first in the world for growth of women in AI, and first in the G7 for year-over-year growth of AI talent. Every year since 2019, Canada has published the most AI-related papers, per capita, in the G7. Our AI firms are filing patents at three times the average rate in the G7, and they are attracting nearly a third of all venture capital in Canada. In 2022-23, there were over 140,000 actively engaged AI professionals in Canada, an increase of 29 per cent compared to the previous year. These are just a few of Canada’s competitive advantages in AI and we are aiming even higher.

To secure Canada’s AI advantage, the government has already:

  • Established the first national AI strategy in the world through the Pan-Canadian Artificial Intelligence Strategy;
  • Supported access to advanced computing capacity, including through the recent signing of a letter of intent with NVIDIA and a Memorandum of Understanding with the U.K. government; and,
  • Scaled-up Canadian AI firms through the Strategic Innovation Fund and Global Innovation Clusters program.
Figure 4.1: Building on  Canada's AI Advantage
Figure 4.1
Building on Canada’s AI Advantage

AI is a transformative economic opportunity for Canada and the government is committed to doing more to support our world-class research community, launch Canadian AI businesses, and help them scale-up to meet the demands of the global economy. The processing capacity required by AI is accelerating a global push for the latest technology, for the latest computing infrastructure.

Currently, most compute capacity is located in other countries. Challenges accessing compute power slows down AI research and innovation, and also exposes Canadian firms to a reliance on privately-owned computing, outside of Canada. This comes with dependencies and security risks. And, it is a barrier holding back our AI firms and researchers.

We need to break those barriers to stay competitive in the global AI race and ensure workers benefit from the higher wages of AI transformations; we must secure Canada’s AI advantage. We also need to ensure workers who fear their jobs may be negatively impacted by AI have the tools and skills training needed in a changing economy.

To secure Canada’s AI advantage Budget 2024 announces a monumental increase in targeted AI support of $2.4 billion, including:

  • $2 billion over five years, starting in 2024-25, to launch a new AI Compute Access Fund and Canadian AI Sovereign Compute Strategy, to help Canadian researchers, start-ups, and scale-up businesses access the computational power they need to compete and help catalyze the development of Canadian-owned and located AI infrastructure. 
  • $200 million over five years, starting in 2024-25, to boost AI start-ups to bring new technologies to market, and accelerate AI adoption in critical sectors, such as agriculture, clean technology, health care, and manufacturing. This support will be delivered through Canada’s Regional Development Agencies.
  • $100 million over five years, starting in 2024-25, for the National Research Council’s AI Assist Program to help Canadian small- and medium-sized businesses and innovators build and deploy new AI solutions, potentially in coordination with major firms, to increase productivity across the country.
  • $50 million over four years, starting in 2025-26, to support workers who may be impacted by AI, such as creative industries. This support will be delivered through the Sectoral Workforce Solutions Program, which will provide new skills training for workers in potentially disrupted sectors and communities.

The government will engage with industry partners and research institutes to swiftly implement AI investment initiatives, fostering collaboration and innovation across sectors for accelerated technological advancement.

Before moving to the part of budget that focuses on safe and responsible use of AI, I’ve got some information about the legislative situation and an omnibus bill C-27 which covers AI, from my October 10, 2024 posting,

The omnibus bill, C-27, which includes Artificial Intelligence and Data Act (AIDA) had passed its second reading in the House of Commons at the time of the posting. Since May 2023, the bill has been the subject of the House of Commons Standing Committee on Industry and Technology according to the Parliament of Canada’s LEGISinfo’s C-27 , 44th Parliament, 1st session Monday, November 22, 2021, to present: An Act to enact the Consumer Privacy Protection Act, the Personal Information and Data Protection Tribunal Act and the Artificial Intelligence and Data Act and to make consequential and related amendments to other Acts webpage.

You can find more up-to-date information about the status of the Committee’s Bill-27 meetings on this webpage where it appears that September 26, 2024 was the committee’s most recent meeting. If you click on the highlighted meeting dates, you will be given the option of watching a webcast of the meeting. The webpage will also give you access to a list of witnesses, the briefs and the briefs themselves.

November 2024 update: The committee’s most recent meeting is still listed as September 26, 2024.

From 4.1 of the budget,

Safe and Responsible Use of AI

AI has tremendous economic potential, but as with all technology, it presents important considerations to ensure its safe development and implementation. Canada is a global leader in responsible AI and is supporting an AI ecosystem that promotes responsible use of technology. From development through to implementation and beyond, the government is taking action to protect Canadians from the potentially harmful impacts of AI.

The government is committed to guiding AI innovation in a positive direction, and to encouraging the responsible adoption of AI technologies by Canadians and Canadian businesses. To bolster efforts to ensure the responsible use of AI:

  • Budget 2024 proposes to provide $50 million over five years, starting in 2024-25, to create an AI Safety Institute of Canada to ensure the safe development and deployment of AI. The AI Safety Institute will help Canada better understand and protect against the risks of advanced and generative AI systems. The government will engage with stakeholders and international partners with competitive AI policies to inform the final design and stand-up of the AI Safety Institute.
  • Budget 2024 also proposes to provide $5.1 million in 2025-26 to equip the AI and Data Commissioner Office with the necessary resources to begin enforcing the proposed Artificial Intelligence and Data Act.
  • Budget 2024 proposes $3.5 million over two years, starting in 2024-25, to advance Canada’s leadership role with the Global Partnership on Artificial Intelligence, securing Canada’s leadership on the global stage when it comes to advancing the responsible development, governance, and use of AI technologies internationally.

Using AI to Keep Canadians Safe

AI has shown incredible potential to toughen up security systems, including screening protocols for air cargo. Since 2012, Transport Canada has been testing innovative approaches to ensure that air cargo coming into Canada is safe, protecting against terrorist attacks. This included launching a pilot project to screen 10 to 15 per cent of air cargo bound for Canada and developing an artificial intelligence system for air cargo screening.

  • Budget 2024 proposes to provide $6.7 million over five years, starting in 2024-25, to Transport Canada to establish the Pre-Load Air Cargo Targeting Program to screen 100 per cent of air cargo bound for Canada. This program, powered by cutting-edge artificial intelligence, will increase security and efficiency, and align Canada’s air security regime with those of its international partners.

There was a small section which updates some information about intellectual property retention (patent box retention) but otherwise is concerned with industrial R&B (a perennial Canadian weakness), from 4.1 of the budget,

Boosting R&D and Intellectual Property Retention

Research and development (R&D) is a key driver of productivity and growth. Made-in-Canada innovations meaningfully increase our gross domestic product (GDP) per capita, create good-paying jobs, and secure Canada’s position as a world-leading advanced economy.

To modernize and improve the Scientific Research and Experimental Development (SR&ED) tax incentives, the federal government launched consultations on January 31, 2024, to explore cost-neutral ways to enhance the program to better support innovative businesses and drive economic growth. In these consultations, which closed on April 15, 2024, the government asked Canadian researchers and innovators for ways to better deliver SR&ED support to small- and medium-sized Canadian businesses and enable the next generation of innovators to scale-up, create jobs, and grow the economy.

  • Budget 2024 announces the government is launching a second phase of consultations on more specific policy parameters, to hear further views from businesses and industry on specific and technical reforms. This includes exploring how Canadian public companies could be made eligible for the enhanced credit. Further details on the consultation process will be released shortly on the Department of Finance Canada website.
  • Budget 2024 proposes to provide $600 million over four years, starting in 2025-26, with $150 million per year ongoing for future enhancements to the SR&ED program. The second phase of consultations will inform how this funding could be targeted to boost research and innovation.

On January 31, 2024, the government also launched consultations on creating a patent box regime to encourage the development and retention of intellectual property in Canada. The patent box consultation closed on April 15, 2024. Submissions received through this process, which are still under review, will help inform future government decisions with respect to a patent box regime.

Nice to get an update on what’s happening with the patent box regime.

The Tri-Council consisting of the Canadian Institutes of Health Research (CIHR), the Natural Sciences and Engineering Research Council of Canada (NSERC), and the Social Sciences and Humanities Research Council of Canada (SSHRC) don’t often get mentioned in the federal budget but they did this year, from 4.1 of the budget,

Enhancing Research Support

Since 2016, the federal government has committed more than $16 billion in research, including funding for the federal granting councils—the Natural Sciences and Engineering Research Council (NSERC), the Canadian Institutes of Health Research (CIHR), and the Social Sciences and Humanities Research Council (SSHRC).

This research support enables groundbreaking discoveries in areas such as climate change, health emergencies, artificial intelligence, and psychological health. This plays a critical role in solving the world’s greatest challenges, those that will have impacts for generations.

Canada’s granting councils already do excellent work within their areas of expertise, but more needs to be done to maximize their effect. The improvements we are making today, following extensive consultations including with the Advisory Panel on the Federal Research Support System, will strengthen and modernize Canada’s federal research support.

  • To increase core research grant funding and support Canadian researchers, Budget 2024 proposes to provide $1.8 billion over five years, starting in 2024-25, with $748.3 million per year ongoing to SSHRC, NSERC, and CIHR.
  • To provide better coordination across the federally funded research ecosystem, Budget 2024 announces the government will create a new capstone research funding organization. The granting councils will continue to exist within this new organization, and continue supporting excellence in investigator-driven research, including linkages with the Health portfolio. This new organization and structure will also help to advance internationally collaborative, multi-disciplinary, and mission-driven research. The government is delivering on the Advisory Panel’s observation that more coordination is needed to maximize the impact of federal research support across Canada’s research ecosystem.
  • To help guide research priorities moving forward, Budget 2024 also announces the government will create an advisory Council on Science and Innovation. This Council will be made up of leaders from the academic, industry, and not-for-profit sectors, and be responsible for a national science and innovation strategy to guide priority setting and increase the impact of these significant federal investments.
  • Budget 2024 also proposes to provide a further $26.9 million over five years, starting in 2024-25, with $26.6 million in remaining amortization and $6.6 million ongoing, to the granting councils to establish an improved and harmonized grant management system.

The government will also work with other key players in the research funding system—the provinces, territories, and Canadian industry—to ensure stronger alignment, and greater co-funding to address important challenges, notably Canada’s relatively low level of business R&D investment.

More details on these important modernization efforts will be announced in the 2024 Fall Economic Statement.

World-Leading Research Infrastructure

Modern, high-quality research facilities and infrastructure are essential for breakthroughs in Canadian research and science. These laboratories and research centres are where medical and other scientific breakthroughs are born, helping to solve real-world problems and create the economic opportunities of the future. World-leading research facilities will attract and train the next generation of scientific talent. That’s why, since 2015, the federal government has made unprecedented investments in science and technology, at an average of $13.6 billion per year, compared to the average from 2009-10 to 2015-16 of just $10.8 billion per year. But we can’t stop here.

To advance the next generation of cutting-edge research, Budget 2024 proposes major research and science infrastructure investments, including:

  • $399.8 million over five years, starting in 2025-26, to support TRIUMF, Canada’s sub-atomic physics research laboratory, located on the University of British Columbia’s Vancouver campus. This investment will upgrade infrastructure at the world’s largest cyclotron particle accelerator, positioning TRIUMF, and the partnering Canadian research universities, at the forefront of physics research and enabling new medical breakthroughs and treatments, from drug development to cancer therapy.
  • $176 million over five years, starting in 2025‑26, to CANARIE, a national not-for-profit organization that manages Canada’s ultra high-speed network to connect researchers, educators, and innovators, including through eduroam. With network speeds hundreds of times faster, and more secure, than conventional home and office networks, this investment will ensure this critical infrastructure can connect researchers across Canada’s world-leading post-secondary institutions.
  • $83.5 million over three years, starting in 2026-27 to extend support to Canadian Light Source in Saskatoon. Funding will continue the important work at the only facility of its kind in Canada. A synchrotron light source allows scientists and researchers to examine the microscopic nature of matter. This specialized infrastructure contributes to breakthroughs in areas ranging from climate-resistant crop development to green mining processes.
  • $45.5 million over five years, starting in 2024-25, to support the Arthur B. McDonald Canadian Astroparticle Physics Research Institute, a network of universities and institutes that coordinate astroparticle physics expertise. Headquartered at Queen’s University in Kingston, Ontario, the institute builds on the legacy of Dr. McDonald’s 2015 Nobel Prize for his work on neutrino physics. These expert engineers, technicians, and scientists design, construct, and operate the experiments conducted in Canada’s underground and underwater research infrastructure, where research into dark matter and other mysterious particles thrives. This supports innovation in areas like clean technology and medical imaging, and educates and inspires the next wave of Canadian talent.
  • $30 million over three years, starting in 2024-25, to support the completion of the University of Saskatchewan’s Centre for Pandemic Research at the Vaccine and Infectious Disease Organization in Saskatoon. This investment will enable the study of high-risk pathogens to support vaccine and therapeutic development, a key pillar in Canada’s Biomanufacturing and Life Sciences Strategy. Of this amount, $3 million would be sourced from the existing resources of Prairies Economic Development Canada.

These new investments build on existing federal research support:

  • The Strategic Science Fund, which announced the results of its first competition in December 2023, providing support to 24 third-party science and research organizations starting in 2024-25;
  • Canada recently concluded negotiations to be an associate member of Horizon Europe, which would enable Canadians to access a broader range of research opportunities under the European program starting this year; and,
  • The steady increase in federal funding for extramural and intramural science and technology by the government which was 44 per cent higher in 2023 relative to 2015.

Advancing Space Research and Exploration

Canada is a leader in cutting-edge innovation and technologies for space research and exploration. Our astronauts make great contributions to international space exploration missions. The government is investing in Canada’s space research and exploration activities.

  • Budget 2024 proposes to provide $8.6 million in 2024-25 to the Canadian Space Agency for the Lunar Exploration Accelerator Program to support Canada’s world-class space industry and help accelerate the development of new technologies. This initiative empowers Canada to leverage space to solve everyday challenges, such as enhancing remote health care services and improving access to healthy food in remote communities, while also supporting Canada’s human space flight program.
  • Budget 2024 announces the establishment of a new whole-of-government approach to space exploration, technology development, and research. The new National Space Council will enable the level of collaboration required to secure Canada’s future as a leader in the global space race, addressing cross-cutting issues that span commercial, civil, and defence domains. This will also enable the government to leverage Canada’s space industrial base with its world-class capabilities, workforce, and track record of innovation and delivery.

I found two responses to the budget from two science organizations and the responses fall into the moderately pleased category. Here’s an April 17, 2024 news release from Evidence for Democracy (E4D), Note: Links have been removed,

As a leading advocate for evidence-informed decision-making and the advancement of science policy in Canada, Evidence for Democracy (E4D) welcomes the budget’s emphasis on scientific research and innovation. Since its inception, E4D has been at the forefront of advocating for policies that support robust scientific research and its integration into public policy. To support this work, we have compiled a budget analysis for the science and research sector here for more context on Budget 2024. 

“Budget 2024 provides an encouraging investment into next generation researchers and research support systems,” says Sarah Laframboise, Executive Director of E4D, “By prioritizing investments in research talent, infrastructure, and innovation, the government is laying the foundation for a future driven by science and evidence.”

The budget’s initiatives to enhance graduate student scholarships and postdoctoral fellowships reflect a commitment to nurturing Canada’s research talent, a cornerstone of E4D’s advocacy efforts through its role on the Coalition for Canadian Research. E4D is encouraged by this investment in next generation researchers and core research grants, who form the bedrock of scientific discovery and drive innovation across sectors. Additionally, the formation of a new capstone research funding organization and Advisory Council on Science and Innovation are signs of a strategic vision that values Canadian science and research.

While Budget 2024 represents a significant step forward for science and research in Canada, E4D recognizes that challenges and opportunities lie ahead. 

“We note that funding for research in Budget 2024 is heavily back-loaded, with larger funding values coming into effect in a few years time,” adds Laframboise, “Given that this also includes significant structural and policy changes, this leaves some concern over the execution and roll-out of these investments in practice.”

As the details of the budget initiatives unfold, E4D remains committed to monitoring developments, advocating for evidence-based policies, and engaging with stakeholders to ensure that science continues to thrive as a driver of progress and prosperity in Canada. 

The April 16, 2024 E4D budget analysis by Farah Qaiser, Nada Salem, Sarah Laframboise, Simarpreet Singh is here. The authors provide more detail than I do.

The second response to the 2024 budget is from the Canadian Institutes of Health Research (CIHR) is posted on a federal government website, from an April 29, 2024 letter, Note: Links have been removed,

Dear colleagues,

On April 16, 2024, the Government of Canada released Budget 2024 – Fairness for Every Generation – a Budget that proposes a historic level of investment in research and innovation. Most notably for CIHR, NSERC, and SSHRC, this included $1.8 billion in core research grant funding over five years (starting in 2024-25, with $748.3 million per year ongoing). This proposed investment recognizes the vital role played by research in improving the lives of Canadians. We are thrilled by the news of this funding and will share more details about how and when these funds will be distributed as the Budget process unfolds.

Budget 2024 also proposes $825 million over five years (starting in 2024-25, with $199.8 million per year ongoing) to increase the annual value of master’s and doctoral student scholarships to $27,000 and $40,000, respectively, and post-doctoral fellowships to $70,000. This will also increase the number of research scholarships and fellowships provided, building to approximately 1,720 more graduate students or fellows benefiting each year. To make it easier for students and fellows to access support, the enhanced suite of scholarships and fellowship programs will be streamlined into one talent program. These proposals are the direct result of a coordinated effort to recognize the importance of students in the research ecosystem.

The Budget proposes other significant investments in health research, including providing:

  • a further $26.9 million over five years (starting in 2024-25, with $26.6 million in remaining amortization and $6.6 million ongoing) to the granting councils to establish an improved and harmonized grant management system.
  • $10 million in 2024-2025 for CIHR to support an endowment to increase prize values awarded by the Gairdner Foundation for excellence in health research.
  • $80 million over five years for Health Canada to support the Brain Canada Foundation in its advancement of brain research.
  • $30 million over three years (starting in 2024-25) to support Indigenous participation in research, with $10 million each for First Nation, Métis, and Inuit partners.
  • $2 billion over five years (starting in 2024-25) to launch a new AI Compute Access Fund and Canadian AI Sovereign Compute Strategy, to help Canadian researchers, start-ups, and scale-up businesses access the computational power they need to compete and help catalyze the development of Canadian-owned and located AI infrastructure.
  • As well, to help guide research priorities moving forward, Budget 2024 announces that the government will create an Advisory Council on Science and Innovation. This Council will be comprised of leaders from the academic, industry, and not-for-profit sectors, and will be responsible for a national science and innovation strategy to guide priority setting and increase the impact of these significant federal investments.

In addition to these historic investments, Budget 2024 includes a proposal to create a “new capstone research funding organization” that will provide improved coordination across the federally funded research ecosystem. This proposal stems directly from the recommendations of the Advisory Panel on the Federal Research Support System, and recognizes the need for more strategic coordination in the federal research system. The Budget notes that the granting councils will each continue to exist within this new organization, and continue supporting excellence in investigator-driven research, including linkages with the Health portfolio. While the governance implications of this new organization are not known at this time, the CIHR Institutes will remain in place as an integral part of CIHR. As stated in the Budget, the timing and details with respect to the creation of this organization still need to be determined, but it did indicate that more details will be announced in the 2024 Fall Economic Statement.

As well, CIHR will be working closely with the Natural Sciences and Engineering Research Council, Social Sciences and Humanities Research Council, Health Canada, and Innovation, Science and Economic Development Canada in the coming months to implement various Budget measures related to research. In the meantime, CIHR will continue its business as usual.

These announcements and investments are significant and unprecedented and will create exciting opportunities for the Tri-Agencies and other partners across the federal research ecosystem to contribute to the health, social, and economic needs and priorities of Canadians. They will also ensure that Canada remains a world leader in science. This is positive and welcome news for the CIHR community. We look forward to embarking on this new journey with Canada’s health research community.

Tammy Clifford, PhD
Acting President, CIHR

Defence

I have taken to including information about the funding for the military on the grounds that the military has historically been the source of much science, medical, and technology innovation. (Television anyone?)

Defence in the 2024 Canadian federal budget is in Chapter 7: Protecting Canadians and Defending Democracy and after a parade of its greatest budget hits from years past, there’s this,

Stronger National Defence

As the world becomes increasingly unstable, as climate change increases the severity and frequency of natural disasters, and as the risk of conflict grows, Canada is asking more of our military. Whether it is deploying to Latvia as part of Operation REASSURANCE, or Nova Scotia as part of Operation LENTUS, those who serve in the Canadian Armed Forces have answered the call whenever they are needed, to keep Canadians safe.

On April 8 [2024], in response to the rapidly changing security environment, the government announced an update to its defence policy: Our North, Strong and Free. In this updated policy, the government laid out its vision for Canada’s national defence, which will ensure the safety of Canadians, our allies, and our partners by equipping our soldiers with the cutting-edge tools and advanced capabilities they need to keep Canadians safe in a changing world.

  • Budget 2024 proposes foundational investments of $8.1 billion over five years, starting in 2024-25, and $73.0 billion over 20 years to the Department of National Defence (DND), the Communications Security Establishment (CSE), and Global Affairs Canada (GAC) to ensure Canada is ready to respond to global threats and to protect the well-being of Canadian Armed Forces members. Canada’s defence spending-to-GDP ratio is expected to reach 1.76 per cent by 2029-30.  These include:
    • $549.4 million over four years, starting in 2025-26, with $267.8 billion in future years, for DND to replace Canada’s worldwide satellite communications equipment; for new tactical helicopters, long-range missile capabilities for the Army, and airborne early warning aircraft; and for other investments to defend Canada’s sovereignty;
    • $1.9 billion over five years, starting in 2024-25, with $8.2 billion in future years, for DND to extend the useful life of the Halifax-class frigates and extend the service contract of the auxiliary oiler replenishment vessel, while Canada awaits delivery of next generation naval vessels;
    • $1.4 billion over five years, starting in 2024-25, with $8.2 billion in future years, for DND to replenish its supplies of military equipment;
    • $1.8 billion over five years, starting in 2024-25, with $7.7 billion in future years, for DND to build a strategic reserve of ammunition and scale up the production of made-in-Canada artillery ammunition. Private sector beneficiaries are expected to contribute to infrastructure and retooling costs;
    • $941.9 million over four years, starting in 2025-26, with $16.2 billion in future years, for DND to ensure that military infrastructure can support modern equipment and operations;
    • $917.4 million over five years, starting in 2024-25, with $10.9 billion in future years and $145.8 million per year ongoing, for CSE and GAC to enhance their intelligence and cyber operations programs to protect Canada’s economic security and respond to evolving national security threats;
    • $281.3 million over five years, starting in 2024-25, with $216 million in future years, for DND for a new electronic health record platform for military health care;
    • $6.9 million over four years, starting in 2025-26, with $1.4 billion in future years, for DND to build up to 1,400 new homes and renovate an additional 2,500 existing units for Canadian Armed Forces personnel on bases across Canada (see Chapter 1);
    • $100 million over five years, starting in 2024-25, to DND for child care services for Canadian Armed Forces personnel and their families (see Chapter 2);
    • $149.9 million over four years, starting in 2025-26, with $1.8 billion in future years, for DND to increase the number of civilian specialists in priority areas; and,
    • $52.5 million over five years, starting in 2024-25, with $54.8 million in future years, to DND to support start-up firms developing dual-use technologies critical to our defence via the NATO Innovation Fund.

To support Our North, Strong and Free, $156.7 million over three years, starting in 2026-27, and $537.7 million in future years would be allocated from funding previously committed to Canada’s 2017 Defence Policy, Strong, Secure, Engaged.

  • Budget 2024 also proposes additional measures to strengthen Canada’s national defence:
    • $1.2 billion over 20 years, starting in 2024-25, to support the ongoing procurement of critical capabilities, military equipment, and infrastructure through DND’s Capital Investment Fund; and,
    • $66.5 million over five years, starting in 2024-25, with $7.4 billion in future years to DND for the Future Aircrew Training program to develop the next generation of Royal Canadian Air Force personnel. Of this amount, $66.5 million over five years, starting in 2024-25, would be sourced from existing DND resources.
  • Budget 2024 also announces reforms to Canadian defence policy and its review processes:
    • Committing Canada to undertake a Defence Policy Review every four years, as part of a cohesive review of the National Security Strategy; and,
    • Undertaking a review of Canada’s defence procurement system.

With this proposed funding, since 2022, the government has committed more than $125 billion over 20 years in incremental funding to strengthen national defence and help keep Canadians and our democracy safe in an increasingly unpredictable world—today and for generations. Since 2015, this adds up to over $175 billion in incremental funding for national defence.

Enhancing CSIS Intelligence Capabilities

As an advanced economy and an open and free democracy, Canada continues to be targeted by hostile actors, which threaten our democratic institutions, diaspora communities, and economic prosperity. The Canadian Security Intelligence Service (CSIS) protects Canadians from threats, such as violent extremism and foreign interference, through its intelligence operations in Canada and around the world.

To equip CSIS to combat emerging global threats and keep pace with technological developments, further investments in intelligence capabilities and infrastructure are needed. These will ensure CSIS can continue to protect Canadians.

  • Budget 2024 proposes to provide $655.7 million over eight years, starting in 2024-25, with $191.1 million in remaining amortization, and $114.7 million ongoing to the Canadian Security Intelligence Service to enhance its intelligence capabilities, and its presence in Toronto.

Maintaining a Robust Arctic Presence

The Canadian Arctic is warming four times faster than the world average, as a result of climate change. It is also where we share a border with today’s most hostile nuclear power—Russia. The shared imperatives of researching climate change where its impacts are most severe, and maintaining an ongoing presence in the Arctic enable Canada to advance this important scientific work and assert our sovereignty.

Maintaining a robust research presence supports Canada’s Arctic sovereignty. Scientific and research operations in the Arctic advance our understanding of how climate change is affecting people, the economy, and the environment in the region. This is an important competitive advantage, as economic competition increases in the region. 

To support research operations in Canada’s North, Budget 2024 proposes:

  • $46.9 million over five years starting in 2024-25, with $8.5 million in remaining amortization and $11.1 million ongoing, to Natural Resources Canada to renew the Polar Continental Shelf Program to continue supporting northern research logistics, such as lodging and flights for scientists; and,
  • $3.5 million in 2024-25 to Polar Knowledge Canada to support its activities, including the operation of the Canadian High Arctic Research Station.

Protecting Canadians from Financial Crimes

Financial crimes are serious threats to public safety, national security, and Canada’s financial system. They can range from terrorist financing, corruption, and the evasion of sanctions, to money laundering, fraud, and tax evasion. These crimes have real world implications, often enabling other criminal behaviour. Financial crime also undermines the fairness and transparency that are so essential to our economy.

Since 2017, the government has undertaken significant work to crack down on financial crime:

  • Investing close to $320 million since 2019 to strengthen compliance, financial intelligence, information sharing, and investigative capacity to support money laundering investigations;
  • Creating new Integrated Money Laundering Investigative Teams in British Columbia, Alberta, Ontario, and Quebec, which convene experts to advance investigations into money laundering, supported by dedicated forensic accounting experts;
  • Launching a publicly accessible beneficial ownership registry for federal corporations on January 22, 2024. The government continues to call upon provinces and territories to advance a pan-Canadian approach to beneficial ownership transparency;
  • Modernizing Canada’s anti-money laundering and anti-terrorist financing framework to adapt to emerging technologies; vulnerable sectors; and growing risks such as sanctions evasion; and,
  • Establishing public-private partnerships with the financial sector, that are improving the detection and disruption of profit-oriented crimes, including human trafficking, online child sexual exploitation, and fentanyl trafficking.

Budget 2024 takes further action to protect Canadians from financial crimes.

Anti-Money Laundering and Anti-Terrorist Financing

Criminal and terrorist organizations continually look for new ways to perpetrate illicit activities. Canada needs a robust legal framework that keeps pace with evolving financial crimes threats.

To combat money laundering, terrorist financing, and sanctions evasion, Budget 2024 announces:

  • The government intends to introduce legislative amendments to the Proceeds of Crime (Money Laundering) and Terrorist Financing Act (PCMLTFA), the Criminal Code the Income Tax Act, and the Excise Tax Act.
    • Proposed amendments to the PCMLTFA would:
      • Enhance the ability of reporting entities under the PCMLTFA to share information with each other to detect and deter money laundering, terrorist financing, and sanctions evasion, while maintaining privacy protections for personal information, including an oversight role for the Office of the Privacy Commissioner under regulations;
      • Permit the Financial Transactions and Reports Analysis Centre of Canada (FINTRAC) to disclose financial intelligence to provincial and territorial civil forfeiture offices to support efforts to seize property linked to unlawful activity; and, Immigration, Refugees and Citizenship Canada to strengthen the integrity of Canada’s citizenship process;
      • Enable anti-money laundering and anti-terrorist financing regulatory obligations to cover factoring companies, cheque cashing businesses, and leasing and finance companies to close a loophole and level the playing field across businesses providing financial services;
      • Allow FINTRAC to publicize more information around violations of obligations under the PCMLTFA when issuing administrative monetary penalties to strengthen transparency and compliance; and,
      • Make technical amendments to close loopholes and correct inconsistencies.
    • Proposed amendments to the Criminal Code would:
      • Allow courts to issue an order to require a financial institution to keep an account open to assist in the investigation of a suspected criminal offence; and,
      • Allow courts to issue a repeating production order to authorize law enforcement to obtain ongoing, specified information on activity in an account or multiple accounts connected to a person of interest in a criminal investigation.
    • Proposed amendments to the Income Tax Act and Excise Tax Act would:
      • Ensure Canada Revenue Agency officials who carry out criminal investigations are authorized to seek general warrants through court applications, thereby modernizing and simplifying evidence gathering processes and helping to fight tax evasion and other financial crimes.

Canada Financial Crimes Agency

As announced in Budget 2023, the Canada Financial Crimes Agency (CFCA) will become Canada’s lead enforcement agency against financial crime. It will bring together expertise necessary to increase money laundering charges, prosecutions, and convictions, and the seizure of criminal assets.

  • Budget 2024 proposes to provide $1.7 million over two years, starting in 2024-25, to the Department of Finance to finalize the design and legal framework for the CFCA.

Fighting Trade-Based Fraud and Money Laundering

  • Trade-based financial crime is one of the most pervasive means of laundering money; it’s estimated that this is how hundreds of millions of dollars are laundered each year. To strengthen efforts to fight trade fraud and money laundering, the 2023Fall Economic Statement announced enhancements to the Canada Border Services Agency’s authorities under the PCMLTFA to combat trade-based financial crime and the intent to create a Trade Transparency Unit.
  • Budget 2024 builds on this work by proposing to provide $29.9 million over five years, starting in 2024-25, with $5.1 million in remaining amortization and $4.2 million ongoing, for the Canada Border Services Agency to support the implementation of its new authorities under the PCMLTFA to combat financial crime and strengthen efforts to combat international financial crime with our allies.

Supporting Veterans’ Well-Being

After their service and their sacrifice, veterans of the Canadian Armed Forces deserve our full support. Veterans’ organizations are often best placed to understand the needs of veterans and to develop programming that improves their quality of life. In 2018, the federal government launched the Veteran and Family Well-Being Fund, which provides funding to public, private, and academic organizations, to advance research projects and innovative approaches to deliver services to veterans and their families.

  • Budget 2024 proposes to provide an additional $6 million over three years, starting in 2024-25, to Veterans Affairs Canada for the Veteran and Family Well-Being Fund. A portion of the funding will focus on projects for Indigenous, women, and 2SLGBTQI+ veterans.

Telemedicine Services for Veterans and Their Families

After serving in the Canadian Armed Forces, many veterans who previously received their health care from the Forces need to find a family doctor in the provincial system, which makes their transition to civilian life more stressful, especially if they need health care for service-related injuries.

To ensure veterans and their families have access to the care they deserve after their service to Canada:

  • Budget 2024 proposes to provide $9.3 million over five years, starting in 2024-25, to Veterans Affairs Canada to extend and expand the Veteran Family Telemedicine Service pilot for another three years. This initiative will provide up to two years of telemedicine services to recent veterans and their families.

I didn’t expect anything on economic matters, from Chapter 7: Protecting Canadians and Defending Democracy,

7.2 Economic Security for Canada and Our Allies

The system of rules and institutions that were established in the wake of the Second World War unleashed an era of prosperity unprecedented in human history. This era generated a massive expansion of global trade, and lifted hundreds of millions of people out of poverty. As a trading nation with privileged access to more than two-thirds of the global economy, Canada has benefitted enormously from the stability and certainty that this system provided.

Supply chain disruptions and rising protectionism threaten this Canadian advantage that has been enjoyed for generations. Canada is taking action to make sure we preserve the rules-based international order. We are strengthening our trade relationships and making sure they reflect our values. We are ensuring our economy is resilient and secure, protecting Canadians and Canada from economic pressure from authoritarian regimes, and defending Canada’s economic interests.

Budget 2024 makes investments to ensure the opportunities and prosperity of trade, enjoyed by generations of Canadians, continue to be there for every generation.

Key Ongoing Actions

  • Launching in 2017 Strong, Secure, Engaged, to maintain the Canadian Armed Forces as an agile, multi-purpose, combat-ready force, ensuring Canada is strong domestically, an active partner in North America, and engaged internationally.
  • Upholding Canada’s 15 free trade agreements with 51 countries. Canada is the only G7 country with comprehensive trade and investment agreements with all other G7 members.
  • Implementing the modernized Canada-Ukraine Free Trade Agreement and the United Kingdom’s accession to the Comprehensive and Progressive Agreement for Trans-Pacific Partnership.
  • Establishing a new Canada-Taiwan foreign investment promotion and protection arrangement in December 2023.
  • Launching Canada’s Indo-Pacific Strategy in November 2022, committing almost $2.3 billion to strengthen Canada’s role as a strong partner in the region. The strategy included:
    • $492.9 million over five years to reinforce Canada’s Indo-Pacific naval presence and increase Canadian Armed Forces participation in regional military exercises.
    • $227.8 million over five years to increase Canada’s work with partners in the region on national security, cyber security, and responses to crime, terrorism, and threats from weapons proliferation.
    • Canada is negotiating free trade agreements with Indonesia and the Association of Southeast Asian Nations to provide additional trade and investment opportunities in the Indo-Pacific region.
  • To further reinforce Canada’s role as a trusted supply chain partner, and its commitment to cooperate with like-minded partners in meeting emerging global challenges, including the economic resilience of the world’s democracies, Canada undertook the following actions:
    • Joined with the U.S. in the Energy Transformation Task Force to accelerate cooperation on critical clean energy opportunities and to strengthen integrated Canada-U.S. supply chains, which as announced in Chapter 4, has been extended for another year.
    • Canada signed a new agreement in May 2023 with South Korea for cooperation on critical mineral supply chains, clean energy transition, and energy security.
    • Canada endorsed the Joint Declaration Against Trade-Related Economic Coercion and Non-Market Policies and Practices with Australia, Japan, New Zealand, the U.K., and the U.S. in June 2023.

Protecting Canadian Businesses from Unfair Foreign Competition

Canadian companies and workers are able to do business around the world, selling their goods and expertise, because the government has delivered free trade agreements that cover 61 per cent of the world’s GDP and 1.5 billion consumers. This means Canadians can do business in Japan and Malaysia with the CPTPP; in Europe with CETA; in the United States and Mexico with the new NAFTA; and in Ukraine with a modernized CUFTA. These agreements mean good jobs and good salaries for people across the country.

However, this is only true when Canadian workers and businesses are competing on an even playing field, and countries respect agreed trade rules.

That is why the government has taken steps to ensure that Canada’s trade remedy and import monitoring systems have the tools needed to defend Canadian workers and businesses from unfair practices of foreign competitors. For instance, earlier this year, Canada introduced a system to track the countries steel imports are initially melted and poured in, to increase supply chain transparency and support effective enforcement of Canada’s trade laws.

  • Budget 2024 proposes to provide $10.5 million over three years, starting in 2024-25, for the Canada Border Services Agency to create a dedicated Market Watch Unit to monitor and update trade remedy measures annually, to protect Canadian workers and businesses from unfair trade practices, and ensure greater transparency and market predictability.

Ensuring Reciprocal Treatment for Canadian Businesses Abroad

Canada is taking action to protect Canadian businesses and workers from additional global economic and trade challenges. These challenges include protectionist and non-market policies and practices implemented by our trading partners. When Canada opens its markets to goods and services from other countries, we expect those countries to equally grant Canadian businesses the access that we provide their companies.

As detailed in the Policy Statement on Ensuring Reciprocal Treatment for Canadian Businesses Abroad, published alongside the 2023 Fall Economic Statement, Canada will consider reciprocity as a key design element for new policies going forward. This approach builds on Canada’s commitment to implement reciprocal procurement policies, including for infrastructure and sub-national infrastructure spending, in the near term. A reciprocal lens will also be applied to a range of new measures including, but not limited to, investment tax incentives, grants and contributions, technical barriers to trade, sanitary and phytosanitary measures, investment restrictions, and intellectual property requirements.

In pursuing reciprocity, Canada will continue working with its allies to introduce incentives for businesses to reorient supply chains to trusted, reliable partners, and will ensure that any new measures do not unnecessarily harm trading partners who do not discriminate against Canadian goods and suppliers.  

Protecting Critical Supply Chains

Recent events around the world, from the pandemic to Russia’s full-scale invasion of Ukraine, have exposed strategic vulnerabilities in critical supply chains, to which Canada and countries around the world are responding by derisking, or friendshoring, their supply chains. Canada is actively working with its allies to strengthen shared supply chains and deepen our economic ties with trusted partners, including in the context of accelerating the transition to a net-zero economy.

Ongoing efforts to build our critical supply chains through democracies like our own represent a significant economic opportunity for Canadian businesses and workers, and the government will continue to design domestic policies and programs with friendshoring as a top-of-mind objective.

To reinforce Canada’s role as a trusted supply chain partner for our allies, Budget 2023 took action to mobilize private investment and grow Canada’s economy towards net-zero. These investments are growing Canada’s economic capacity in industries across the economy, while simultaneously reducing Canada’s emissions and strengthening our essential trading relationships.

Eradicating Forced Labour from Canadian Supply Chains

Canada is gravely concerned by the ongoing human rights violations against Uyghurs and Muslim minorities in China, as well as by the use of forced labour around the world. 

  • Budget 2024 reaffirms the federal government’s commitment to introduce legislation in 2024 to eradicate forced labour from Canadian supply chains and to strengthen the import ban on goods produced with forced labour. The government will also work to ensure existing legislation fits within the overall framework to safeguard our supply chains.

This will build on funding committed in the 2023 Fall Economic Statement that, starting January 1, 2024, supports the requirement for annual reporting from public and private entities to demonstrate measures they have taken to prevent and reduce the risk that forced labour is used in their supply chains.

Before moving on to an interesting analysis of the defence portion of the 2024 budget by someone else, here’s a link to the national defence policy, Our North, Strong and Free: A Renewed Vision for Canada’s Defence, which was released on April 8, 2024 just days before the April 16, 2024 release date for this latest federal budget.

It seems there was a shift in policy during the nine-day interval. From Murray Brewster’s April 16, 2024 article for the Canadian Broadcasting Corporation’s (CBC) news online website, Note: Links have been removed,

The new federal budget promises good things will happen at the Department of National Defence … next year, and hopefully in the years after.

The new fiscal plan, presented Tuesday by Finance Minister Chrystia Freeland, marks a subtle but significant shift from what was proposed in last week’s long-awaited defence policy [emphasis mine], which committed to spending an additional $8.1 billion on defence.

The funding envelope in the budget earmarks the same amount but includes not only the defence department but proposed spending on both the Communications Security Establishment — the country’s electronic spy agency — and Global Affairs Canada. [emphases mine]

While the overall defence budget is expected to increase marginally in the current fiscal year to $33.8 billion, defence experts told CBC News that when the internal cost-cutting exercise ordered by the Liberal government and the new defence policy are factored in, the military can expect roughly $635 million less this year [emphasis mine] than was anticipated before spending restraint kicked in.

Freeland’s fiscal plan projects a 30 per cent increase in defence spending in the next fiscal year, bringing it to $44.2 billion.

This is how I understand what Brewster is saying:

  • 2024/25 defence budget as listed is $33.8B
  • Not all of this money is going directly to defence (the Communications Security Establishment and Global Affairs Canada will be partaking)
  • the defence department has been ordered to cut costs
  • so, there will be $635M less than defence might have expected
  • in 2025/26 defence spending will be increased to $44.2 billion, whatever that means

That’s quite the dance and Brewster’s April 16, 2024 article points out at least one more weakness,

Sahir Khan, the executive vice-president of the University of Ottawa’s Institute of Fiscal Studies and Democracy, said he would love to see the specifics.

“That’s one of the difficulties, I think, with this government is we have seen a lot of aspiration, but not always the perspiration,” said Khan, a former deputy parliamentary budget officer. “What is the plan to achieve the results?”

The politically charged promise to increase Canada’s defence spending to 1.76 per cent of the gross domestic product by the end of the decade could be left in doubt when the spending plans are laid alongside the budget’s economic projections during that time frame.

Generally, the better the economy does, the more the defence budget would have to be increased to meet the target.

“It’s really unclear how we actually get to 1.76 per cent of GDP, if you take the figures that are presented which outline how spending is going to increase,” said Dave Perry, a defence expert and president of the Canadian Global Affairs Institute.

“You can’t put that against the nominal GDP projection provided in the budget” and then add in other government departments, such as Veterans Affairs Canada, “and get anywhere close” to the GDP projection in the defence policy, he said.

There are more questions about the proposed defence spending in the 2024 federal budget in Brewster’s other April 16, 2024 article for CBC (Critics attack long timelines in defence plan as military awaits a budget boost).

About five weeks after the budget was released, Prime Minister Justin Trudeau received a letter, from a May 23, 2024 article by Alexander Panetta for CBC News online,

Nearly one-quarter of the members of the United States Senate have sent an unusually critical letter to Prime Minister Justin Trudeau expressing dismay over Canada’s level of defence spending.

They pressed Trudeau to come to this summer’s NATO summit with a plan to fulfil Canada’s commitment to reach the alliance’s longstanding spending target.

The letter from 23 members of the U.S. Senate, from both parties, represents a dramatic and public escalation of pressure from Washington over a longstanding bilateral irritant.

That written critique [letter] comes just days after Defence Minister Bill Blair completed what he referred to as a productive trip to Washington to promote Canada’s new military strategy.

“We are concerned and profoundly disappointed,” says the letter, referring to the spending levels in the strategy Blair came to promote.

The pressure is continuing at this year’s Halifax [Nova Scotia, Canada] International Security Forum held from November. 22 – 24, 2024 as can be seen in Sean Boynton’s November 24, 2024 article (includes embedded video) for Global News

A bipartisan pair of U.S. senators say they expect Canada and the U.S. to work collaboratively on shared issues of defence and the border, but suggested Ottawa’s policies on military spending need to change to speed up progress.

Speaking to Mercedes Stephenson from the Halifax International Security Forum in an interview that aired Sunday on The West Block, Republican Sen. James Risch of Idaho and Democratic Sen. Jeanne Shaheen of New Hampshire downplayed concerns that incoming president-elect Donald Trump will penalize Canada on things like trade if it doesn’t step up on defence spending.

As far as I’m concerned, this budget offers some moderate gains from a science and technology perspective and with regard to military spending, it seems a little lacklustre overall and with regard to military research, that might be called nonexistent.

More dirt from Saskatoon’s synchrotron (Canadian Light Source)

Apparently, dirt is not welcome at most synchrotrons (also known as light sources) as was noted in my November 13, 2022 posting about Saskatoon’s synchrotron being used to analyze some soil from Hawaii. This time, according to a September 4, 2024 Canadian Light Source (CLS) news release by Rowan Hollinger (also received via email), the soil is from Kansas and there appears to be a second synchroton involved in this research,

With carbon dioxide levels in the atmosphere increasing in recent decades, there is a growing urgency to find strategies for capturing and holding carbon.

Researchers from Kansas State University (K-State) are exploring how different farming practices can affect the amount of carbon that gets stored in soil. Using the Canadian Light Source (CLS) at the University of Saskatchewan (USask) and the Advanced Light Source in Berkeley, California, they analyzed soil from a cornfield in Kansas that had been farmed with no tilling for the past 22 years. During that time, the farm used a variety of different soil nitrogen management practices, including no fertilizer, chemical fertilizer, and manure/compost fertilizer.

“We were trying to understand what the mechanisms are behind increasing soil carbon storage using certain management practices,” says Dr. Ganga Hettiarachchi, professor of soil and environmental chemistry at Kansas State University. “We were looking at not just soil carbon, but other soil minerals that are going to help store carbon.”

As has been shown in other studies, the K-state researchers found that the soil enhanced (treated) with manure or compost fertilizer stores more carbon than soil that received either chemical fertilizer or no fertilizer. More exciting though, says Hettiarachchi, the ultrabright synchrotron light enabled them to see how the carbon gets stored: they found that it was preserved in pores and some carbon had attached itself to minerals in the soil.

The team also found that the soil treated with manure or compost contained more microbial carbon, an indication that these enhancements support more microorganisms and their activities in the soil. In addition, they identified special minerals in the soil, evidence Hettiarachchi says, that the treatments contribute to active chemical and biological processes.

“To my knowledge, this is the first direct evidence of mechanisms through which organic enhancements improve soil health, microbial diversity, and carbon sequestration.”

Because synchrotron imaging is non-destructive, the K-state researchers were able to observe what was going on in soil aggregate (clumps) without having to break up the soil; essentially, they were looking at the carbon chemistry in its natural state.

“Collectively, studies like this are going to help us to move forward to more sustainable, more regenerative agriculture practices that will protect our soils and environment as well as help feed growing populations, says Hettiarachchi. “As well, understanding the role of the different minerals, chemicals, and microbes involved will help improve models for predicting how different farming practices affect soil carbon storage.”

Here’s a link to and a citation for the paper,

Direct evidence on the impact of organic amendments on carbon stabilization in soil microaggregates by Pavithra S. Pitumpe Arachchige, Ganga M. Hettiarachchi, Charles W. Rice, James J. Dynes, Leila Maurmann, A. L. David Kilcoyne, Chammi P. Attanayake. Soil Science Society of America Journal (2024) DOI: https://doi.org/10.1002/saj2.20701 First published: 21 June 2024

This paper is behind a paywall.

Using copper to mitigate climate change?

A July 4, 2024 news item on phys.org announces research into copper that mitigates climate change,

Carbon in the atmosphere is a major driver of climate change. Now researchers from McGill University have designed a new catalyst for converting carbon dioxide (CO2) into methane—a cleaner source of energy—using tiny bits of copper called nanoclusters. While the traditional method of producing methane from fossil fuels introduces more CO2 into the atmosphere, the new process, electrocatalysis, does not.

A July 4, 2024 Canadian Light Source (CLS) news release (also received via email) by Rowan Hollinger, which originated the news item, delves further into the research, Note: A link has been removed,

“On sunny days you can use solar power, or when it’s a windy day you can use that wind to produce renewable electricity, but as soon as you produce that electricity you need to use it,” says Mahdi Salehi, Ph.D. candidate at the Electrocatalysis Lab at McGill University. “But in our case, we can use that renewable but intermittent electricity to store the energy in chemicals like methane.”

By using copper nanoclusters, says Salehi, carbon dioxide from the atmosphere can be transformed into methane and once the methane is used, any carbon dioxide released can be captured and “recycled” back into methane. This would create a closed “carbon loop” that does not emit new carbon dioxide into the atmosphere. The research, published recently in the journal Applied Catalysis B: Environment and Energy, was enabled by the Canadian Light Source (CLS) at the University of Saskatchewan (USask).

“In our simulations, we used copper catalysts with different sizes, from small ones with only 19 atoms to larger ones with 1000 atoms,” says Salehi. “We then tested them in the lab, focusing on how the sizes of the clusters influenced the reaction mechanism.”

“Our top finding was that extremely small copper nanoclusters are very effective at producing methane,” continues Salehi. “This was a significant discovery, indicating that the size and structure of the copper nanoclusters play a crucial role in the reaction’s outcome.”

The team plans to continue refining their catalyst to make it more efficient and investigate its large-scale, industrial applications. Their hope is that their findings will open new avenues for producing clean, sustainable energy.

Researcher Mahdi Salehi describes his work in a video provided by the Canadian Light Source (CLS),

Here’s a link to and a citation for the paper,

Copper nanoclusters: Selective CO2 to methane conversion beyond 1 A/cm² by Mahdi Salehi, Hasan Al-Mahayni, Amirhossein Farzi, Morgan McKee, Sepideh Kaviani, Elmira Pajootan, Roger Lin, Nikolay Kornienko, Ali Seifitokaldani. Applied Catalysis B: Environment and Energy Volume 353, 15 September 2024, 124061 DOI: https://doi.org/10.1016/j.apcatb.2024.124061 Available online 9 April 2024, Version of Record 12 April 2024.

This paper is open access. Under a Creative Commons license

Layer of tin could prevent short-circuiting in lithium-ion batteries

Lithium-ion batteries are everywhere; they can be found in cell phones, laptops, e-scooters, e-bikes, and more. There are also some well documented problems with the batteries including the danger of fire. With the proliferating use of lithium-ion batteries, it seems fires are becoming more frequent as Samantha Murphy Kelly documents in her Mach 9, 2023 article for CNN news online, Note: Links have been removed,

Lithium-ion batteries, found in many popular consumer products, are under scrutiny again following a massive fire this week in New York City thought to be caused by the battery that powered an electric scooter.

At least seven people have been injured in a five-alarm fire in the Bronx which required the attention of 200 firefighters. Officials believe the incident stemmed from a lithium-ion battery of a scooter found on the roof of an apartment building. In 2022, the the New York City Fire Department responded to more than 200 e-scooter and e-bike fires, which resulted in six fatalities.

“In all of these fires, these lithium-ion fires, it is not a slow burn; there’s not a small amount of fire, it literally explodes,” FDNY [Fire Dept. New York] Commissioner Laura Kavanagh told reporters. “It’s a tremendous volume of fire as soon as it happens, and it’s very difficult to extinguish and so it’s particularly dangerous.”

A residential fire earlier this week in Carlsbad, California, was suspected to be caused by an e-scooter lithium battery. On Tuesday [March 7, 2023], an alarming video surfaced of a Canadian homeowner running downstairs to find his electric bike battery exploding into flames. [emphasis mine] A fire at a multi-family home in Massachusetts last month is also under investigation for similar issues.

These incidents are becoming more common for a number of reasons. For starters, lithium-ion batteries are now in numerous consumer tech products,powering laptops, cameras, smartphones and more. They allow companies to squeeze hours of battery life into increasingly slim devices. But a combination of manufacturer issues, misuse and aging batteries can heighten the risk from the batteries, which use flammable materials.

“Lithium batteries are generally safe and unlikely to fail, but only so long as there are no defects and the batteries are not damaged or mistreated,” said Steve Kerber, vice president and executive director of Underwriters Laboratory’s (UL) Fire Safety Research Institute (FSRI). “The more batteries that surround us the more incidents we will see.”

In 2016, Samsung issued a global recall of the Galaxy Note 7 in 2016, citing “battery cell issues” that caused the device to catch fire and at times explode. [emphasis mine] HP and Sony later recalled lithium computer batteries for fire hazards, and about 500,000 hoverboards were recalled due to a risk of “catching fire and/or exploding,” according to the U.S. Consumer Product Safety Commission.

In 2020, the Federal Aviation Administration [emphasis mine] banned uninstalled lithium-ion metal batteries from being checked in luggage and said they must remain with a passenger in their carry-on baggage, if approved by the airline and between 101-160 watt hours. “Smoke and fire incidents involving lithium batteries can be mitigated by the cabin crew and passengers inside the aircraft cabin,” the FAA said.

Despite the concerns, lithium-ion batteries continue to be prevalent in many of today’s most popular gadgets. Some tech companies point to their abilities to charge faster, last longer and pack more power into a lighter package.

But not all lithium batteries are the same.

Kelly’s Mach 9, 2023 article describes the problems (e.g., a short circuit) that may cause fires and includes some recommendations for better safety and for what to do in the event of a lithium-ion battery fire.Her mention of Samsung and the fires brought back memories; it was mentioned here briefly in a December 21, 2016 post titled, “The volatile lithium-ion battery,” which mostly featured then recent research into the batteries and fires.

More recently, I’ve got an update of sorts on lithium-ion batteries and fires on airplanes, from the May/June 2024 posting of the National Business Aviation Association (NBAA) Insider,

A smoke, fire or extreme heat incident involving lithium ion batteries takes place aboard an aircraft more than once per week [emphases mine] on average in the U.S., making it imperative for operators to fully understand these dangerous events and to prepare crews with safety training.

At any given time, there could be more than 1,000 Li-ion powered devices on board an airliner, while an international business jet might easily be flying with a few dozen. Despite their popularity, few people realize the dangers posed by Li-ion batteries.

Hazards run the gamut, from overheating, to emitting smoke, to bursting into flames or even exploding – spewing bits of white hot gel in all directions. In fact, a Li-ion fire can begin as a seemingly harmless overheat and erupt into a serious hazard in a matter of seconds.

FAA [US Federal Aviation Administration] data shows the scope of the threat: In 2023, more than one Li-ion incident occurred aboard an aircraft each week. Specifically, the agency said there were 208 issues with lithium ion battery packs, 111 with e-cigarettes and vaping devices, 68 with cell phones and 60 with laptop computers. (The FAA doesn’t offer incident data by aircraft type.

Thankfully, the data shows the chances of encountering an unstable mobile device aboard a business aircraft are small. But so is the possibility of a passenger experiencing a heart attack – yet many business aircraft carry defibrillators.

The threat with lithium ion batteries is known as thermal runaway. When a Li-ion battery overheats due to some previous damage that creates a short circuit [emphasis mine], the unit continues a catastrophic internal chain reaction until it melts or catches fire.

Short circuits, lithium ion batteries, and the University of Alberta

A July 31, 2024 Canadian Light Source (CLS) news release (also received via email) by Greg Basky announces the University of Alberta research,

Lithium-ion batteries have a lot of advantages. They charge quickly, have a high energy density, and can be repeatedly charged and discharged.

They do have one significant shortcoming, however: they’re prone to short-circuiting.  This occurs when a connection forms between the two electrodes inside the cell. A short circuit can result in a sudden loss of voltage or the rapid discharge of high current, both causing the battery to fail. In extreme cases, a short circuit can cause a cell to overheat, start on fire, or even explode. Video: Thin layer of tin prevents short-circuiting in lithium-ion batteries

A leading cause of short circuits are rough, tree-like crystal structures called dendrites that can form on the surface of one of the electrodes. When dendrites grow all the way across the cell and make contact with the other electrode, a short circuit can occur.

Using the Canadian Light Source (CLS) at the University of Saskatchewan (USask), researchers from the University of Alberta (UAlberta) have come up with a promising approach to prevent formation of dendrites in solid-state lithium-ion batteries. They found that adding a tin-rich layer between the electrode and the electrolyte helps spread the lithium around when it’s being deposited on the battery, creating a smooth surface that suppresses the formation of dendrites. The results are published in the journal ACS Applied Materials and Interfaces [ACS is American Chemical Society]. The team also found that the cell modified with the tin-rich structure can operate at a much higher current and withstand many more charging-discharging cycles than a regular cell.

Researcher Lingzi Sang, an assistant professor in UAlberta’s Faculty of Science (Chemistry), says the CLS played a key role in the research. “The HXMA beamline enabled us to see at a material’s structural level what was happening on the surface of the lithium in an operating battery,” says Sang. “As a chemist, what I find the most intriguing is we were able to access the exact tin structure that we introduced to the interface which can suppress dendrites and fix this short-circuiting problem.” In a related paper the team published earlier this year, they showed that adding a protective layer of tin also suppressed the formation of dendrites in liquid-electrolyte-based lithium-ion batteries.

This novel approach holds considerable potential for industrial applications, according to Sand. “Our next step is to try to find a sustainable, cost-effective approach to applying the protective layer in battery production.”

Here’s a link to and a citation for the latest paper,

Dual-Component Interlayer Enables Uniform Lithium Deposition and Dendrite Suppression for Solid-State Batteries by Xiang You, Ning Chen, Geng Xie, Shihong Xu, Sayed Youssef Sayed, and Lingzi Sang. ACS Appl. Mater. Interfaces 2024, 16, 27, 35761–35770 DOI: https://doi.org/10.1021/acsami.4c05227 Published June 21, 2024 Copyright © 2024 American Chemical Society

This paper is behind a paywall.

Reusable ‘sponge’ for soaking up marine oil spills—even in northern waters

A May 28, 2024 news item on phys.org announces some new research into sponges, a topic of some interest where oil spill cleanups are concerned,

Oil spills, if not cleaned up quickly and effectively, can cause lasting damage to marine and coastal environments. That’s why a team of North American researchers are developing a new sponge-like material that is not only effective at grabbing and holding oil on its surface (adsorption), but can be reused again and again—even in icy Canadian waters….

A May 27, 2024 Canadian Light Source (CLS) news release (also received via email) by Rowan Hollinger provides some details, Note: CNF can be cellulose nanofibers, cellulose nanofibrils, or, it’s sometimes called, nanofibrillated cellulose (NFC) (see Nanocellulose Wikipedia entry),,

The special material – called CNF-SP aerogel — combines a biodegradable cellulose-based material with a substance called spiropyran, a light-sensitive material. Spiropyran has a unique ‘switchable’ property that allows the aerogel to go between being oil-sorbent and oil-repellent, just like a kitchen sponge that can be used to soak up and squeeze out water.

“Once spiropyran has been added to the aerogel, after each usage we just switch the light condition,” explains Dr. Baiyu Helen Zhang, professor and Canada Research Chair at Memorial University, Newfoundland. “We used the aerogel as an oil sorbent under visible light. After oil adsorption, we switched the light condition to UV light. This switch helped the sponge to release the oil.”

And the material continues soaking up and releasing oil, even when the water temperature drops, according to Dr. Xiujuan Chen, an assistant professor at University of Texas – Arlington.

“We found that when we tested the oil sorbent’s performance under different kinds of environmental conditions, it had a very good performance in a cold environment. This is quite useful for cold winter seasons, particularly for Canada.”

The researchers used the CLS’s Mid-IR beamline to examine the characteristics of the aerogel before and after exposing it to visible and UV light. From here, the researchers are looking to scale up their research with large pilot studies and even testing the material in the field.

“The CLS has very unique infrastructure that supports students and researchers like us to conduct many kinds of very exciting research and to contribute to scientific knowledge and engineering applications,” says Zhang.

Here’s a link to and a citation for the paper,

Development of a spiropyran-assisted cellulose aerogel with switchable wettability as oil sorbent for oil spill cleanup by Hongjie Wang, Xiujuan Chen, Bing Chen, Yuming Zhao, Baiyu Zhang. Science of The Total Environment Volume 923, 1 May 2024, 171451 DOI: https://doi.org/10.1016/j.scitotenv.2024.171451 Available online: 2 March 2024 Version of Record: 8 March 2024

This paper is behind a paywall.

The CLS has made this video of the researchers available,

For the curious, I have many posts about sponges and, in particular, sponges for use in environmental cleanups.

Pulp and paper waste for scrubbing carbon from emissions

This first news release is a little short but the next one is one of the shortest I can recall seeing. First, a February 1, 2024 Canadian Light Source (CLS) news release by Victoria Martinez,

Researchers at McGill University have come up with an innovative approach to improve the energy efficiency of carbon conversion, using waste material from pulp and paper production. The technique they’ve pioneered using the Canadian Light Source at the University of Saskatchewan not only reduces the energy required to convert carbon into useful products, but also reduces overall waste in the environment.

“This is a new field,” says Roger Lin, a graduate student in chemical engineering “We are one of the first groups to combine biomass recycling or utilization with CO2 capture.” The research team, from McGill’s Electrocatalysis Lab, published their findings in the journal RSC [Royal Society of Chemistry] Sustainability.

Capturing carbon emissions is one of the most exciting emerging tools to fight climate change. The biggest challenge is figuring out what to do with the carbon once the emissions have been removed, especially since capturing CO2 can be expensive. The next hurdle is that transforming CO2 into useful products takes energy. Researchers want to make the conversion process as efficient and profitable as possible.

“For these reactions, it really matters that we target energy efficiency,” says Amirhossein Farzi, a PhD student in chemical engineering at McGill. “The highest burden on the profitability of these reactions and these processes is usually how energy efficient they are.”

Farzi, Lin, and their research team focused their efforts on changing out one of the most energy-intensive parts of the carbon conversion process.

Because the approach is so new, there are many questions to answer about how to get the purest outputs and best efficiency. The team used CLS beamlines to observe chemical reactions in real-time, mimicking industrial processes as closely as possible.

The researchers hope to expand the range of products that can be made with CO2, and help develop a truly green technology.

“If we use a renewable energy source like hydro, wind, or solar …then in the end, we have really a carbon negative process,” says Lin.

Then, there was a March 27, 2024 McGill University news release (also on EurekAlert but published April 8, 2024), which is more succinct,

Researchers at McGill University have come up with an innovative approach to improve the energy efficiency of carbon conversion, using waste material from pulp and paper production. The technique they’ve pioneered using the Canadian Light Source at the University of Saskatchewan not only reduces the energy required to convert carbon into useful products, but also reduces overall waste in the environment.

“We are one of the first groups to combine biomass recycling or utilization with CO2 capture,” said Ali Seifitokaldani, Assistant Professor in the Department of Chemical Engineering and Canada Research Chair (Tier II) in Electrocatalysis for Renewable Energy Production and Conversion. The research team, from McGill’s Electrocatalysis Lab, published their findings in the journal RSC Sustainability.

Capturing carbon emissions is one of the most exciting emerging tools to fight climate change. The biggest challenge is figuring out what to do with the carbon once the emissions have been removed, especially since capturing CO2 can be expensive. The next hurdle is that transforming CO2 into useful products takes energy. Researchers want to make the conversion process as efficient and profitable as possible.

Here’s a link to and a citation for the paper,

Efficient integration of carbon dioxide reduction and 5-hydroxymethylfurfural oxidation at high current density by Roger Lin, Haoyan Yang, Hanyu Zheng, Mahdi Salehi, Amirhossein Farzi, Poojan Patel, Xiao Wang, Jiaxun Guo, Kefang Liu, Zhengyuan Gao, Xiaojia Li, Ali Seifitokaldani. RSC Sustainability, 2024; 2 (2): 445 DOI: 10.1039/D3SU00379E First published online: 13 Dec 2023

This paper is open access.

H/t April 8, 2024 news item on ScienceDaily

Better vaccines for park producers?

From a February 27, 2024 Canadian Light Source (CLS) news release (also received via email) by Erin Matthews,

A long-term, international collaboration between researchers at the University of Manitoba and the Leiden University Medical Centre in the Netherlands has uncovered vital information about the porcine reproductive and respiratory syndrome virus (PRRSV). This pathogen causes severe disease in pigs, leading to significant economic losses for pork producers across the globe.

“This disease in pigs is important worldwide and is economically fairly significant,” says Marjolein Kikkert, Associate Professor of Virology at Leiden University Medical Centre. “The aim of the project was to improve vaccines for this disease, and it turned out that it was very difficult.” It’s estimated that PRRS costs the Canadian pork industry $130M annually.

Kikkert and collaborator Brian Mark, Dean of the Faculty of Science at the University of Manitoba, looked at targeting a type of protein called a protease. PRRSV uses these proteins to suppress a host’s immune system, causing severe illness. By changing the structure, researchers can design altered viruses upon which to base new vaccines.

With the help of the Canadian Light Source (CLS) at the University of Saskatchewan (USask), Mark and Kikkert were able to visualize the unique structure of the PRRSV protease. What they learned in their study is valuable for developing new vaccines against PRRSV and also helps inform development of vaccines against emerging human viruses.

The team has conducted similar research on coronaviruses —which also use proteases to suppress human and animal immune systems — and has successfully designed new vaccines.

“The trick and hypothesis we had for improving the PRRSV vaccine didn’t quite work.” Says Kikkert. “However, we did learn a lot about how these viruses work. And it may certainly be a basis for further work into possibilities for improving vaccines against these viruses and coronaviruses.”

The team’s findings also unlock new doors to understanding how viruses like PRRSV use proteins to replicate, making this a significant academic discovery.

“The Canadian Light Source provided the technology we needed to determine the structures of these proteases, and this knowledge has provided tremendous insight into the biochemistry of these viruses, which is the cornerstone of modern vaccine development,” says Mark.

Here’s a link to and a citation for the paper,

Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis by Ben A. Bailey-Elkin, Robert C. M. Knaap, Anuradha De Silva, Ilse M. Boekhoud, Sandra Mous, Niek van Vught, Mazdak Khajehpour, Erwin van den Born, Marjolein Kikkert, Brian L. Mark. PLOS DOI: https://doi.org/10.1371/journal.ppat.1011872 Published: December 14, 2023

This paper is open access.