Chinese researchers have taken a step closer to constructing complex (lifelike) liver tissue according to a Jan. 27, 2016 American Chemical Society (ACS) news release (also on EurekAlert),
Engineered liver tissue could have a range of important uses, from transplants in patients suffering from the organ’s failure to pharmaceutical testing [this usage is sometimes known as liver-on-a-chip]. Now scientists report in ACS’ journal Analytical Chemistry the development of such a tissue, which closely mimics the liver’s complicated microstructure and function more effectively than existing models.
The liver serves a critical role in digesting food and detoxifying the body. But due to a variety of factors, including viral infections, alcoholism and drug reactions, the organ can develop chronic or acute problems. When it doesn’t work well, a person can suffer abdominal pain, swelling, nausea and other symptoms. Complete liver failure can be life-threatening and can require a transplant, a procedure that currently depends on human donors. To curtail this reliance and provide an improved model for predicting drugs’ side effects, scientists have been engineering liver tissue in the lab. But so far, they haven’t achieved the complex architecture of the real thing. Jinyi Wang and colleagues came up with a new approach.
Wang’s team built a microfluidics-based tissue that copies the liver’s complex lobules, the organ’s tiny structures that resemble wheels with spokes. They did this with human cells from a liver and an aorta, the body’s main artery. In the lab, the engineered tissue had a metabolic rate that was closer to real-life levels than other liver models, and it successfully simulated how a real liver would react to various drug combinations. The researchers conclude their approach could lead to the development of functional liver tissue for clinical applications and screening drugs for side effects and potentially harmful interactions.
Here’s a link to and a citation for the paper,
On-Chip Construction of Liver Lobule-like Microtissue and Its Application for Adverse Drug Reaction Assay by Chao Ma, Lei Zhao, En-Min Zhou, Juan Xu, Shaofei Shen, and Jinyi Wang. Northwest A&F University, China Anal. Chem., Article ASAP DOI: 10.1021/acs.analchem.5b03869 Publication Date (Web): January 7, 2016
Copyright © 2016 American Chemical Society
This paper is behind a paywall.
In a teleconference earlier this month (January 2016), I spoke to researchers at the University of Malaya, Universiti Teknologi Malaysia (UTM), and Harvard University about a joint lung and nanomedicine research project where I asked researcher Joseph Brain (Harvard) about using lung-on-a-chip testing in place of in vivo (animal) testing and he indicated more confidence in the ‘precision cut lung slices’ technique. (You can find out more about the Malaysian project in my Jan. 12, 2016 posting but there’s only a brief mention of Brain’s preferred alternative animal testing technique.)