Today (May 19, 2025) I have two stories, one about a new nano comic from the Czech republic and one with an overview of some nano comic books from the past.
Czech Academy of Sciences and Secrets of the Nano-World
How many nanometres does your hand measure? Why does nothing stand still in the nano- world? And what does atomic force microscopy allow us to do? This and more is revealed in the new comic book Secrets of the Nano-World, published by the Institute of Physics of the Czech Academy of Sciences. The comic book introduces the frequently mentioned, but rarely taught topic of nanotechnology to (not only) students and teachers.
It was the end of 1959 when physicist Richard Feynman, in his lecture “There is plenty of room at the bottom”, presented visions of the then-unimaginable miniaturisation and its consequences. Today, we encounter nanotechnology at every turn, often without realising it. How did we get here, how can we even imagine a nanoscale world, and where is nanotechnology heading? That’s what Sofia and Alex, high school students on a science internship, find out in the comic, as they are mysteriously transported back in time to the very moments of Feynman’s lecture and try to get back to their own present.
“Taking Sofia and Alex back in time allowed us to introduce the inventions that made the development of nanotechnology possible,” explains Julie Nekola Nováková, the story’s creator and a member of the outreach team at the Institute of Physics (FZU). “We would never have gotten to where we are without, say, the atomic force microscope. And how difficult is it to manipulate individual atoms? Readers can try that out on a larger scale with a little experiment!”
Prokop Hapala, who is involved in computational design of molecular machines at the FZU, consulted on the scientific and technical side of the comic. “I think it’s important for students to think of molecules not as abstract formulas on paper, but real objects that can be touched, broken and built again,” Prokop Hapala explains.
The comic was drawn by the artist Vojtěch Šeda, known mainly for his illustrations of historical books and comics. “What I enjoy about drawing comics is when I learn something new in the process,” says Vojtěch Šeda. “In the case of the comic about nanotechnology, which was a big step into the unknown for me at the beginning, this was 100% true.”
The authors have further plans for the comic book. “If you’ve had a chance to read it, you’ll know there’s room for a possible sequel… There are also plans for using elements of the comic in worksheets, infographics and physics-themed colouring pages,” explains Julie Nekola Nováková.
The comic book is freely available under the Creative Commons license CC BY-SA 4.0, making it possible to translate it to other languages and otherwise use in science outreach and education across the globe.
Provided by Institute of Physics of the Czech Academy of Sciences
The educational comic book Secrets of the Nano- World is intended primarily for pupils of secondary schools and high schools. Its protagonists are two high school students Sofie and Alex, who mysteriously find themselves in the past during their internship – at the very end of 1959 at the time of Richard Feynman’s lecture that essentially launched the field of nanotechnology. And it is the famous scientist who is drawn into trying to help Alex and Sofie get back to their own time. To do so, however, they’ll need considerable knowledge of the world in the nano- dimensions…
h/t May 7, 2025 Google Alert
(Nano)technology in Comics (mostly from the NanoKOMIK Project)
Comic books are popular science communication vehicles that have their up and down cycles. Right now (2025) they seem to be experiencing the up part of the cycle. In doing a little research I stumbled across this article from last year, which critically analyzed the 2016 – 2017 NanoKOMIK Project,
Representations of science and technology, embodied as imaginaries, visions, and expectations, have become a growing focus of analysis. These representations are of interest to normative approaches to science and technology, such as Hermeneutic Technology Assessment and Responsible Innovation, because of their ability to modulate understandings of science and technology and to influence scientific and technological development. This article analyses the culture of participation underlying the NanoKOMIK project and the representations and meanings of (nano)science and (nano)technology communicated in the two nano-fiction comic books created as part of the project: Dayanne and Murillo. The power of nanoscience (2016) and NanoKOMIK #2 (2017). The article argues that despite NanoKOMIK’s efforts to engage the public with (nano)science and (nano)technology, it reproduces non-binding modes of public participation and transmits socio-technical meanings that are instrumental in the social legitimisation of (nano)technology. More specifically, the analysis shows that NanoKOMIK’s comic books, in addition to not problematising the risks and conveying an eminently positive view of nanotechnology, also communicate certain ‘myth-conceptions’ of scientific activity and its products. For example, they convey an individualistic and linear vision of research and innovation and an instrumentalist and neutral (or ‘value-free’) view of technology. These findings highlight the importance of critically analysing the ‘cultures of participation’ that characterise and reproduce ‘participatory’ or ‘collaborative’ projects and the representations of (nano)science and (nano)technology that they perpetuate.
I was particularly interested in this section from the paper’s Introduction, Note: Links have been removed,
A growing body of literature has highlighted the various benefits of comics in stimulating imagination and learning, especially among young people inside and outside the classroom. Comics are expected to help broaden thematic knowledge and promote greater engagement with science (e.g. [14,15,16,17,18,19,20,21]). Although it is recognised that implementing comics as an educational and engagement tool requires appropriate mediation, this creative and communicative medium is seen as a fruitful resource for improving the meaning-making processes in science and technology (e.g. [22]). Despite the limited exploration of comics as a communication tool in the specific field of nanotechnology, there is support for the idea that comics can benefit specific target groups in several respects (e.g. [23, 24]).
Inspired by the creative potential of comics, several projects have been launched to develop and disseminate comic strips focusing on nanotechnology ‘superpowers’, particularly targeting middle- and high-school students. Examples include (i) Nano BlasterMan (2005), produced by the Taiwanese Ministry of Education; (ii) Dayanne and Murillo. The power of nanoscience (2016) and NanoKOMIK #2 (2017), produced as part of the ‘NanoKOMIK’ project (2016–2017) and co-funded by the Spanish Foundation for Science and Technology and the Ministry of Economy, Industry and Competitiveness (see https://www.nanokomik.com); and (iii) the comic competition ‘Generation Nano! Superheroes Inspired by Science!’ (2017), funded by the National Science Foundation and the National Nanotechnology Initiative of the United States (see http://nsf.gov/GenNano). [all emphases mine]
I always appreciate learning about comics and science communication efforts even if it happens 20 years after the fact (e.g., Nano BlasterMan from 2005). As for the ‘Generation Nano! …’ US competition, that seems to have run from 2016 to 2018. I have announcements for winners of the 2016 competition in my April 21, 2016 posting and winners of the 2017 competition in my July 10, 2017 posting. There was, apparently, a 2018 competition but all I have is a notice that there be an announcement of the 2018 winners at the 2018 USA Science & Engineering Festival (in my October 9, 2017 posting; scroll down about 40% of the way ) but never followed up with the winners’ announcement—until now! See this April 6, 2018 US National Science Foundation news release on EurekAlert. I can’t find any mention of a 2019 competition.
Getting back on track, this paper is quite accessible (assuming you can stomach some amount of jargon) and timely given what seems to be a resurgence of interest in using comic books for science communication.
One last thing, you can find the NanoKOMIC Project here, although it does not seem to be an active project at this time.
This news comes from the University of Edinburgh (Scotland). From an October 10, 2023 news item on phys.org, Note: A link has been removed,
Scientists have used gene editing techniques to identify and change parts of chicken DNA that could limit the spread of the bird flu virus in the animals.
Researchers were able to restrict—but not completely block—the virus from infecting chickens by altering a small section of their DNA.
The birds showed no signs that the change in their DNA had any impact on their health or well-being.
The findings are an encouraging step forward, but experts highlight that further gene edits would be needed to produce a chicken population which cannot be infected by bird flu—one of the world’s most costly animal diseases.
Scientists from University of Edinburgh, Imperial College London and the Pirbright Institute bred the chickens using gene editing techniques to alter the section of DNA responsible for producing the protein ANP32A. During an infection, flu viruses hijack this molecule to help replicate themselves.
When the ANP32A gene-edited chickens were exposed to a normal dose of the H9N2-UDL strain of avian influenza virus – commonly known as bird flu – 9 out of 10 birds remained uninfected and there was no spread to other chickens.
Partial protection
The research team then exposed the gene-edited birds to an artificially high dose of avian influenza virus to further test their resilience.
When exposed to the high dose, half of the group – 5 out of 10 birds – became infected. However, the gene edit did provide some protection, with the amount of virus in the infected gene-edited chickens much lower than the level typically seen during infection in non-gene-edited chickens.
The gene edit also helped to limit onward spread of the virus to just one of four non-gene-edited chickens placed in the same incubator. There was no transmission to gene-edited birds.
Viral evolution
Scientists found that in the ANP32A gene-edited birds, the virus had adapted to enlist the support of two related proteins – ANP32B and ANP32E – to replicate.
Following lab tests, scientists found that some of the mutations enabled the virus to utilise the human version of ANP32, but its replication remained low in cell cultures from the human airway.
Experts say that additional genetic changes would be needed for the virus to infect and spread effectively in humans.
However, the findings demonstrate that the single ANP32A gene edit is not robust enough for application in the production of chickens, according to the team.
Gene editing
Scientists from University of Edinburgh, Imperial College London and the Pirbright Institute bred the chickens using gene editing techniques to alter the section of DNA responsible for producing the protein ANP32A. During an infection, flu viruses hijack this molecule to help replicate themselves.
When the ANP32A gene-edited chickens were exposed to a normal dose of the H9N2-UDL strain of avian influenza virus – commonly known as bird flu – 9 out of 10 birds remained uninfected and there was no spread to other chickens.
Partial protection
The research team then exposed the gene-edited birds to an artificially high dose of avian influenza virus to further test their resilience.
When exposed to the high dose, half of the group – 5 out of 10 birds – became infected. However, the gene edit did provide some protection, with the amount of virus in the infected gene-edited chickens much lower than the level typically seen during infection in non-gene-edited chickens.
The gene edit also helped to limit onward spread of the virus to just one of four non-gene-edited chickens placed in the same incubator. There was no transmission to gene-edited birds.
Viral evolution
Scientists found that in the ANP32A gene-edited birds, the virus had adapted to enlist the support of two related proteins – ANP32B and ANP32E – to replicate.
Following lab tests, scientists found that some of the mutations enabled the virus to utilise the human version of ANP32, but its replication remained low in cell cultures from the human airway.
Experts say that additional genetic changes would be needed for the virus to infect and spread effectively in humans.
However, the findings demonstrate that the single ANP32A gene edit is not robust enough for application in the production of chickens, according to the team.
Further edits
To prevent the emergence of escape viruses – viruses that adapt to evade the gene edit and cause infection – the research team next targeted additional sections of DNA responsible for producing all three proteins – ANP32A, ANP32B and ANP32E – inside lab-grown chicken cells.
In cell cultures in the lab, growth of the virus was successfully blocked in cells with the three gene edits.
The next step will be to try to develop chickens with edits to all three genes. No birds have been produced yet.
The study highlights the importance of responsible gene editing and the need to be alert to the risks of driving viral evolution in unwanted directions if complete resistance is not achieved, experts say.
Bird flu is a major global threat, with a devastating impact in both farmed and wild bird populations. In the UK alone, the current outbreak of H5N1 bird flu has decimated seabird populations and cost the poultry industry more than £100 million in losses.
In rare instances, mutations in the bird flu virus allow it to infect people and cause serious illness. Efforts to control the spread of the disease are urgently needed.
“Bird flu is a great threat to bird populations. Vaccination against the virus poses a number of challenges, with significant practical and cost issues associated with vaccine deployment. Gene-editing offers a promising route towards permanent disease resistance, which could be passed down through generations, protecting poultry and reducing the risks to humans and wild birds. Our work shows that stopping the spread of avian influenza in chickens will need several simultaneous genetic changes.” Professor Mike McGrew, The study’s principal investigator, from the University of Edinburgh’s Roslin Institute
“This work is an exciting collaboration that fuses our expertise in virology with the world-leading genetic capability at the Roslin Institute. Although we haven’t yet got the perfect combination of gene edits to take this approach into the field, the results have told us a lot about how influenza virus functions inside the infected cell and how to slow its replication.” Professor Wendy Barclay, Imperial College London
The research was funded by UKRI-BBSRC, which also provides strategic funding to The Roslin Institute, and was supported by Edinburgh Innovations, the University’s commercialisation service.
Scientists have successfully used gene editing techniques to limit the spread of bird flu in chickens.
In a UK first, researchers have been able to restrict, but not completely block, the avian influenza virus from infecting the birds by precisely altering a small section of their DNA.
The modified birds showed no signs that the change had any impact on the animals’ health or well-being.
But the researchers say that while the findings are encouraging, further gene edits would be needed to produce chickens which cannot be infected by bird flu.
The study, carried out by researchers from the University of Edinburgh, Imperial College London and the Pirbright Institute, is published in the journal Nature Communications.
Professor Wendy Barclay, Head of the Department of Infectious Disease at Imperial College London, said: “This work is an exciting collaboration that fuses our expertise in virology with the world world-leading genetic capability at the Roslin Institute.
“Although we haven’t yet got the perfect combination of gene edits to take this approach into the field, the results have told us a lot about how influenza virus functions inside the infected cell and how to slow its replication.”
Global Threat
Bird flu is a major global threat, with a devastating impact in both farmed and wild bird populations. In the UK alone, the current outbreak of H5N1 bird flu has decimated seabird populations and cost the poultry industry more than £100 million in losses.
In the latest study, researchers aimed to test whether precise edits to the chicken’s genome could potentially generate birds which are resistant to the virus.
The team bred chickens with small edits to a gene called ANP32A. During an infection, influenza viruses hijack the ANP32A protein to help replicate themselves.
But when the gene-edited birds were exposed to a normal dose of virus (the H9N2 strain of avian influenza), 9 out of 10 birds remained uninfected and there was no spread to other chickens.
When the birds were exposed to an artificially high dose of virus, only half of them became infected. The single gene edit also provided some protection against transmission, with a much lower amount of virus in infected gene-edited birds compared to non-edited birds.
In addition, the edit also helped to limit onward spread of the virus to just one of four non-edited chickens placed in the same incubator. There was no transmission to gene-edited birds.
Triple edits
Analysis revealed that in the edited birds, the virus adapted to enlist the support of two related proteins to replicate – ANP32B and ANP32E.
Following lab tests, the researchers found some of the mutations may enable the virus to utilise the human version of ANP32, but replication remained low in cell cultures from the human airway. The researchers stress that additional genetic changes would be needed for the virus to have the potential to infect and spread effectively in humans.
According to the team, the findings demonstrate that a single gene edit is not robust enough to produce resistant chickens. To prevent the emergence of viruses able to adapt to the single edit, the team next used a triple edit to target additional proteins (ANP32A, ANP32B and ANP32E) in lab-grown chicken cells.
In cell cultures in the lab, growth of the virus was successfully blocked in cells with edits to all three genes. In future, researchers hope to develop chickens with this triple edit, but no birds have been produced at this stage.
According to the researchers, the study highlights the importance of responsible gene editing and the need to be alert to the risks of driving viral evolution in unwanted directions if complete resistance is not achieved, experts say.
Professor Mike McGrew, from the University of Edinburgh’s Roslin Institute and principal investigator of the study, said: “Bird flu is a great threat to bird populations. Vaccination against the virus poses a number of challenges, with significant practical and cost issues associated with vaccine deployment.
“Gene-editing offers a promising route towards permanent disease resistance, which could be passed down through generations, protecting poultry and reducing the risks to humans and wild birds. Our work shows that stopping the spread of avian influenza in chickens will need several simultaneous genetic changes.”
A non-gene-edited chicken (left) pictured next to an ANP32A gene-edited chicken (right). Image credit: Norrie Russell Courtesy: University of Edinburgh
There’s also an October 10, 2023 article by Jon Cohen for Science.org, which gives some idea of how much work it took to get to this point, Note: Links have been removed,
For 3 decades, Helen Sang has tinkered with the genomes of chickens to try to make the birds resistant to the flu viruses that periodically devastate flocks and raise fears of a human pandemic. Now, as an especially virulent strain of avian influenza sweeps through poultry and wild birds around the world, the geneticist at the University of Edinburgh’s Roslin Institute has her first solid success. Using the CRISPR gene editor and recent findings about what makes poultry vulnerable to flu, Sang and colleagues from three other institutions have created chickens that can resist real-life doses of avian flu viruses. “Sticking to it gets you somewhere in the end,” she says.
The result, published today [October 5, 2023] in Nature Communications, is “a long-awaited achievement,” says Jiří Hejnar, a virologist at the Czech Academy of Sciences’s Institute of Molecular Genetics whose group showed in 2020 that CRISPR-edited chickens could resist a cancer-causing virus. But farmers won’t be raising flu-proof chickens anytime soon. The edited birds still became infected when exposed to larger amounts of the flu virus. And the strategy raises a safety concern: chickens edited this way could, in theory, drive the evolution of flu variants better at infecting people. “What this showed is a proof of concept,” says Wendy Barclay, a virologist at Imperial College London who worked on the new study. “But we’re not there yet.”
…
Here’s a link to and a citation for the paper,
Creating resistance to avian influenza infection through genome editing of the ANP32 gene family by Alewo Idoko-Akoh, Daniel H. Goldhill, Carol M. Sheppard, Dagmara Bialy, Jessica L. Quantrill, Ksenia Sukhova, Jonathan C. Brown, Samuel Richardson, Ciara Campbell, Lorna Taylor, Adrian Sherman, Salik Nazki, Jason S. Long, Michael A. Skinner, Holly Shelton, Helen M. Sang, Wendy S. Barclay & Mike J. McGrew. Nature Communications volume 14, Article number: 6136 (2023) DOI: https://doi.org/10.1038/s41467-023-41476-3 Published: 10 October 2023
A September 30, 2021 news item on Nanowerk a new material for treating skin infections (Note: A link has been removed),
Researchers at the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague) and the Technical University of Liberec in collaboration with researchers from the Institute of Microbiology of the CAS, the Department of Burns Medicine of the Third Faculty of Medicine at Charles University (Czech Republic), and P. J. Šafárik University in Košice (Slovakia) have developed a novel antibacterial material combining nonwoven nanotextile and unique compounds with antibacterial properties (Scientific Reports, “Novel lipophosphonoxin-loaded polycaprolactone electrospun nanofiber dressing reduces Staphylococcus aureus induced wound infection in mice”).
Because the number of bacterial strains resistant to common antibiotics is steadily increasing, there is a growing need for new substances with antibacterial properties. A very promising class of substances are the so-called lipophosphonoxins (LPPO) developed by the team of Dominik Rejman of IOCB Prague in collaboration with Libor Krásný of the Institute of Microbiology of the CAS.
“Lipophosphonoxins hold considerable promise as a new generation of antibiotics. They don’t have to penetrate the bacteria but instead act on the surface, where they disrupt the bacterial cell membrane. That makes them very efficient at destroying bacteria,” says Rejman.
“A big advantage of LPPO is the limited ability of bacteria to develop resistance to them. In an experiment lasting several weeks, we failed to find a bacteria resistant to these substances, while resistance to well-known antibiotics developed relatively easily,” explains Krásný.
The potential of LPPO is especially evident in situations requiring immediate targeted intervention, such as skin infections. Here, however, the substances must be combined with a suitable material that ensures their topical efficacy without the need to enter the circulatory system. This reduces the burden to the body and facilitates use.
One such suitable material is a polymer nanofiber developed by the team of David Lukáš of the Faculty of Science, Humanities and Education at the Technical University of Liberec. The researchers combined it with LPPO to prepare a new type of dressing material for bacteria-infected skin wounds. The material’s main benefit is that the antibacterial LPPO are released from it gradually and in relation to the presence and extent of infection.
“The research and development of the material NANO-LPPO is a continuation of the work carried out in a clinical trial on the NANOTARDIS medical device, which we recently successfully completed in collaboration with Regional Hospital Liberec, University Hospital Královské Vinohrady, and Bulovka University Hospital. With its morphological and physical-chemical properties, the device promotes the healing of clean acute wounds,” says Lukáš. “This collaboration with colleagues from IOCB Prague is really advancing the possibilities for use of functionalized nanofiber materials in the areas of chronic and infected wounds.”
“Enzymes decompose the nanomaterial into harmless molecules. The LPPO are an integral component of the material and are primarily released from it during this decomposition. Moreover, the process is greatly accelerated by the presence of bacteria, which produce lytic enzymes. This means that the more bacteria there are in the wound, the faster the material decomposes, which in turn releases more of the active substances into the affected site to promote healing and regeneration of soft tissues,” says Rejman in describing the action of the material.
“Our experiments on mice confirmed the ability of NANO-LPPO to prevent infection in the wound and thus accelerate healing and regeneration. There was practically no spread of infection where we used the material. If clinical trials go well, this could be a breakthrough in the treatment of burns and other serious injuries where infection poses an acute threat and complication to treatment,” explains wound care specialist Peter Gál of the Department of Burns Medicine at Charles University’s Third Faculty of Medicine, the Faculty of Medicine at P. J. Šafárik University in Košice, and the East Slovak Institute for Cardiovascular Diseases.
In terms of applications, NANO-LPPO is an interesting material for manufacturers of medicinal products and medical devices. Its commercialization is being coordinated through a collaborative effort between IOCB TECH, a subsidiary of IOCB Prague, and Charles University Innovations Prague, a subsidiary of Charles University, both of which were created for the purpose of transferring results of academic research to practice. The companies are currently seeking a suitable commercial partner.
Here’s a link to and a citation for the paper,
Novel lipophosphonoxin-loaded polycaprolactone electrospun nanofiber dressing reduces Staphylococcus aureus induced wound infection in mice by Duy Dinh Do Pham, Věra Jenčová, Miriam Kaňuchová, Jan Bayram, Ivana Grossová, Hubert Šuca, Lukáš Urban, Kristýna Havlíčková, Vít Novotný, Petr Mikeš, Viktor Mojr, Nikifor Asatiani, Eva Kuželová Košťáková, Martina Maixnerová, Alena Vlková, Dragana Vítovská, Hana Šanderová, Alexandr Nemec, Libor Krásný, Robert Zajíček, David Lukáš, Dominik Rejman & Peter Gál. Scientific Reports volume 11, Article number: 17688 (2021) DOI: https://doi.org/10.1038/s41598-021-96980-7 Published: 03 September 2021
