The future will be beautiful if scientists are successful with a new DNA (deoxyribonucleic acid) sunscreen (my Aug. 3, 2017 posting) and a new dental material for people with sensitive teeth. From an Aug. 2, 2017 news item on phys.org,
An ice cold drink is refreshing in the summer, but for people with sensitive teeth, it can cause a painful jolt in the mouth. This condition can be treated, but many current approaches don’t last long. Now researchers report in the journal ACS [American Chemical Society] Applied Materials & Interfaces the development of a new material with an extract from green tea that could fix this problem—and help prevent cavities in these susceptible patients.
An Aug. 2, 2017 ACS news release, which originated the news item, describes the problem and the work in more detail,
Tooth sensitivity commonly occurs when the protective layers of teeth are worn away, revealing a bony tissue called dentin. This tissue contains microscopic hollow tubes that, when exposed, allow hot and cold liquids and food to contact the underlying nerve endings in the teeth, causing pain. Unprotected dentin is also vulnerable to cavity formation. Plugging these tubes with a mineral called nanohydroxyapatite is a long-standing approach to treating sensitivity. But the material doesn’t stand up well to regular brushing, grinding, erosion or acid produced by cavity-causing bacteria. Cui Huang and colleagues wanted to tackle sensitivity and beat the bacteria at the same time.
The researchers encapsulated nanohydroxyapatite and a green tea polyphenol — epigallocatechin-3-gallate, or EGCG — in silica nanoparticles, which can stand up to acid and wear and tear. EGCG has been shown in previous studies to fight Streptococcus mutans, which forms biofilms that cause cavities. Testing on extracted wisdom teeth showed that the material plugged the dentin tubules, released EGCG for at least 96 hours, stood up to tooth erosion and brushing and prevented biofilm formation. It also showed low toxicity. Based on these findings, the researchers say the material could indeed be a good candidate for combating tooth sensitivity and cavities.
The authors acknowledge funding from the National Natural Science Foundation of China, the Natural Science Foundation of Hubei Province of China and the Fundamental Research Funds for the Central Universities.
Here’s a link to and a citation for the paper,
Development of Epigallocatechin-3-gallate-Encapsulated Nanohydroxyapatite/Mesoporous Silica for Therapeutic Management of Dentin Surface by Jian Yu, Hongye Yang, Kang Li, Hongyu Ren, Jinmei Lei, and Cui Huang. ACS Appl. Mater. Interfaces, Article ASAP DOI: 10.1021/acsami.7b06597 Publication Date (Web): July 13, 2017
Copyright © 2017 American Chemical Society
This paper is behind a paywall.