Tag Archives: Exposure to nanoparticles is related to pleural effusion

New digital technologies could unlock greater potential for microbes and fungi and some thoughts on civil society groups

Not sure how this escaped my notice for so long: an August 7, 2024 news item on phys.org presents an intriguing proposition,

Microbes and fungi have long been nature’s helpers in producing fine food, drinks and medicine, but new digital technologies could unlock far greater potential for the European biotech sector.

An August 6, 2024 article by Anthony King for Horizon; The EU Research & *Innovation magazine, which originated the news item, explores the matter further, Note: A link has been removed,

Beer may not be the answer to all of life’s problems, but the science behind it could help decarbonise industrial processes and clean up the environment.

Biotechnology, which uses living organisms to create different products or processes, remains important in today’s production of food and drink. But it is also increasingly used for a wide range of industrial products, including medicines, where it combines ancient principles with cutting-edge technology.

Ancient wisdom, modern processes

‘We’ve used biotechnology for thousands of years to make cheese, to make beer, to make wine,’ said Michael O’Donohue, an expert in microbial enzymes and industrial biotechnology at France’s National Research Institute for Agriculture, Food and Environment (INRAE).

Little workhorses

Biotech has already transformed our lives, far beyond improving the taste of beer. Modern advances started with the use of fungi in the early 20th century to make life-saving antibiotics. Today, biotech remains crucial for making medicines.

As O’Donohue explained, ‘the workhorses of biotechnology at an industrial level are mainly yeast and filamentous fungi.’ 

But because yeasts can be unpredictable in what compound, and how much, they produce, Bioindustry 4.0 [EU-funded project], which runs until December 2026, will use digital technology to improve the consistency of biotech outcomes.

An upside of biotechnology is that it can offer a cleaner alternative to traditional chemical manufacture.

Playing catch-up

Biotech is a major global industry worth €720 billion in 2021, but Europe currently lags behind the US. The European Commission describes biotechnology as “one of the most promising technological areas of this century” and has taken steps to boost it in Europe.

‘The US is the big player. They take 60% of the cake,’ said O’Donohue. ‘We’ve identified several weaknesses in Europe for biotech. We’ve got a fragmented landscape, which makes it quite tricky, if you are developing biotechnology, to know what is available and where.’

Nevertheless, O’Donohue said, the potential is there. ‘Europe was the birthplace of modern biotechnology. We have a lot of infrastructure. We have a lot of expertise.’

Building the market

The concept has already been put to work, assisting young European companies such as Calidris Bio, a Belgian start-up that aims to manufacture high-quality protein using fewer resources. 

‘We want to bring it to the market as an ingredient to replace fishmeal and soy that at the moment is not grown sustainably,’ said Lieve Hoflack, a co-founder of Calidris Bio. 

But producing the protein is just half the battle. A new product must be tested for safety, taste and nutritional value. 

‘With IBISBA, we found a place with the right equipment, the right expertise and also the right mindset to bring our process to the next step,’ said Hoflack.

The European Commission has said it aims to boost biotechnology to combat climate change and resource scarcity. It is working towards an EU Biotech Act and aims to promote regulatory sandboxes to test novel approaches in a controlled environment for a limited amount of time, under regulatory supervision.

IBISBA describes itself as “a pan-European distributed research infrastructure dedicated to industrial biotechnology” on its About webpage.

Civil society groups and their protests

As interesting as King’s August 6, 2024 article is, it doesn’t mention the campaigns against biotechnology, which had a dampening effect on research in many countries. Here’s more about the history of these efforts in an October 9, 2023 article on the Genetic Literacy Project website, Note: Links have been removed,

ETC Group: ‘Extreme’ biotechnology critic campaigns against synthetic biology and other forms of ‘extreme genetic engineering’

screen shot at pm

The ETC group, an international NGO based in Canada, claims it monitors the “impact of emerging technologies” that impact biodiversity, agriculture and human rights. It promotes imposing an extreme version of the ‘precautionary principle’ to all technologies, claiming that many modern innovations, including genetic engineering of crops and medicines, are too risky to implement, and even basic research should be suspended indefinitely.

ETC Group works with other radical environmental groups such as Friends of he Earth, campaigning against nearly every application of genetic engineering, including biotechnology-based disease research, synthetic biology, and most aggressively gene drives, which it refers to as “extreme genetic engineering” an claims it will result in the “end of Nature.” ETC Group calls has criticized increased corporate involvement in food and agriculture, what it calls threats to biodiversity and farmers’ rights, and what it sees as insufficient government regulation.

“The speed with which those developments are scaling up is often presented in terms of carefully crafted speculative conservation and health benefits while the overwhelming military interest driving these developments, while not hidden, has been very much downplayed,” ETC Group co-executive director Jim Thomas has said, citing the military’s interest in synthetic biology.

ETC Group staff members are often quoted by major media outlets criticizing various applications of genetic engineering. The organization has used Freedom of Information Acts (FOIA) to obtain emails and background information on university and government research, which they provide to journalists.

Obviously, the article was not written as a love letter. While I find the tone a bit harsh, I have seen how at least one civil society group has distorted research results to prove its point. More about that later.

ETC history

From the October 9, 2023 article for the Genetic Literacy Project, Note: A link has been removed,

Originally formed in the late 1970s as Rural Advancement Foundation International (RAFI), the group changed its name to the ETC Group in 2001. Its official name is the Action Group on Erosion, Technology and Concentration.

ETC Group is a registered CSO in Canada and The Netherlands. Friends of ETC Group is a private non-profit organization under section 501(c)3 in the United States.

The group claims to be the “first civil society organization (nationally or internationally) to draw attention to the socioeconomic and scientific issues related to the conservation and use of plant genetic resources, intellectual property and biotechnology.”

According to the group’s website, “In the late 1970s, we were the first CSO to recognize the trend toward life patenting and the first to organize against national plant patenting laws (plant breeders’ rights).” In the 1990s, the ETC Group says its work “expanded to encompass social and environmental concerns related to biotechnology, biopiracy, human genomics and, in the late 1990s, to nanotechnology.” [emphases mine]

Distortions

By the time I started this blog in May/June 2008, the biotechnology protests were winding down. One of the new focal points for civil society groups was nanotechnology and that’s where I observed the distortions.

A Friends of the Earth (FOE) report

My first observation dates as far back as this August 20, 2009 posting, Note: Links have been removed,

In a bit of interesting timing given that it’s on the heels of the publication of a study about two tragic deaths which are being attributed to exposure to nanoparticles, the Friends of the Earth (FOE) organization has released a report titled Nano-Sunscreens: Not Worth the Risk.The media release can be found on Azonano or Nanowerk News.

I have read the report (very quickly) and noted that they do not cite or mention the recently released report on the same topic by the Environmental Working Group (EWG) which stated that after an extensive review of the literature, there was no evidence that the titanium dioxide or zinc oxide nanoparticles used in sunscreens were dangerous. (posting here).

Shortly after the EWG report’s release, a new study (which I mentioned here … if you are inclined, do read the comments as some additional points about reading research critically are brought out)  suggested concerns based on the work of researchers in Japan.  The new study from Japan is cited in the Friends of the Earth report.

While the overall tone of the FOE report is fairly mild (they suggest precaution) they cite only a few studies supporting their concern [emphasis mine] and they damage their credibility (in my book) by ignoring a report from a well respected group that reluctantly admitted that there is no real cause for concern about nanoparticles in sunscreens based on the current evidence.

Zinc dioxide nanoparticles in sunscreens

About a year later in a July 20, 2010 posting I featured some issues with how Friends of the Earth (Georgia Miller, Australian representative, and Ian Illuminato, North American representative) guest blogging on another blog known as “2020 Science” distorted research findings from a study on zinc oxide nanoparticles in sunscreens. Dr. Andrew Maynard, the blog owner, made some critical observations about their posting. In addition, the researcher for the study, along with two other scientists, noted distortions in the Miller and Illumanito critique.

Two Chinese workers, nanoparticles and death

This excerpt from a July 26, 2011 posting is my critique of an article by Alex Roslin in a local newspaper, which relied almost exclusively on a report from the Friends of the Earth,

It’s good to see articles about nanotechnology. The recent, Tiny nanoparticles could be a big problem, article written by Alex Roslin for the Georgia Straight (July 21, 2011 online or July 21-28, 2011 paper edition) is the first I’ve seen on that topic in that particular newspaper. Unfortunately, there are  some curious bits of information included in the article, which render it, in my opinion, difficult to trust.

I do agree with Roslin that nanoparticles/nanomaterials could constitute a danger and there are a number of studies which indicate that, at the least, extreme caution in a number of cases should be taken if we choose to proceed with developing nanotechnology-enabled products.

One of my difficulties with the article is the information that has been left out. (Perhaps Roslin didn’t have time to properly research?) At the time (2009) I did read with much concern the reports Roslin mentions about the Chinese workers who were injured and/or died after working with nanomaterials. As Roslin points out,

“Nanotech already appears to be affecting people’s health. In 2009, two Chinese factory workers died and another five were seriously injured in a plant that made paint containing nanoparticles.

The seven young female workers developed lung disease and rashes on their face and arms. Nanoparticles were found deep in the workers’ lungs.

“These cases arouse concern that long-term exposure to some nanoparticles without protective measures may be related to serious damage to human lungs,” wrote Chinese medical researchers in a 2009 study on the incident in the European Respiratory Journal.”

Left undescribed by Roslin are the working conditions; the affected people were working in an unventilated room. From the European Respiratory Journal article (ERJ
September 1, 2009 vol. 34 no. 3 559-567, free access), Exposure to nanoparticles is related to pleural effusion, pulmonary fibrosis and granuloma,

“A survey of the patients’ workplace was conducted. It measures ∼70 m2, has one door, no windows and one machine which is used to air spray materials, heat and dry boards. This machine has three atomising spray nozzles and one gas exhauster (a ventilation unit), which broke 5 months before the occurrence of the disease. The paste material used is an ivory white soft coating mixture of polyacrylic ester.

Eight workers (seven female and one male) were divided into two equal groups each working 8–12 h shifts. Using a spoon, the workers took the above coating material (room temperature) to the open-bottom pan of the machine, which automatically air-sprayed the coating material at the pressure of 100–120 Kpa onto polystyrene (PS) boards (organic glass), which can then be used in the printing and decorating industry. The PS board was heated and dried at 75–100°C, and the smoke produced in the process was cleared by the gas exhauster. In total, 6 kg of coating material was typically used each day. The PS board sizes varied from 0.5–1 m2 and ∼5,000 m2 were handled each workday. The workers had several tasks in the process including loading the soft coating material in the machine, as well as clipping, heating and handling the PS board. Each worker participated in all parts of this process.

Accumulated dust particles were found at the intake of the gas exhauster. During the 5 months preceding illness the door of the workspace was kept closed due to cold outdoor temperatures. The workers were all peasants near the factory, and had no knowledge of industrial hygiene and possible toxicity from the materials they worked with. The only personal protective equipment used on an occasional basis was cotton gauze masks. According to the patients, there were often some flocculi produced during air spraying, which caused itching on their faces and arms. It is estimated that the airflow or turnover rates of indoor air would be very slow, or quiescent due to the lack of windows and the closed door.” [emphases mine]

Here’s the full text from the researchers’ conclusion,

“In conclusion, these cases arouse concern that long-term exposure to some nanoparticles without protective measures may be related to serious damage to human lungs. It is impossible to remove nanoparticles that have penetrated the cell and lodged in the cytoplasm and caryoplasm of pulmonary epithelial cells, or that have aggregated around the red blood cell membrane. Effective protective methods appear to be extremely important in terms of protecting exposed workers from illness caused by nanoparticles.”

There is no question that serious issues about occupational health and safety with regards to nanomaterials were raised. But, we work with dangerous and hazardous materials all the time; precautions are necessary whether you’re working with hydrochloric acid or engineered nanoparticles. (There are naturally occurring nanoparticles too.)

In general, I found the tenor of the article more alarmist than informational and I’m sorry about that as I would like to see more information being shared and, ultimately, public discussion in Canada about nanotechnology and other emerging technologies.

Unintended consequences

After years of concerted effort the Friends of the Earth saw this result in Australia,

Friends of the Earth (FoE) Australia has waged a campaign against the use of nanosunscreens. It seems to have been somewhat successful but in a way that I imagine is upsetting. From the Feb. 9, 2012 news item on physorg.com,

The Cancer Council of Australia reports that we have one of the highest rates of skin cancer in the world, with over 440,000 people receiving medical treatment for skin cancers each year, and over 1,700 people dying of all types of skin cancer annually.

The survey of public attitudes towards sunscreens with nanoparticles, commissioned by the Australian Department of Industry, Innovation, Science, Research and Tertiary Education and conducted last month, showed that about 17% of people in Australia were so worried about the issue, they would rather risk skin cancer by going without sunscreen than use a product containing nanoparticles. [emphasis mine] [please see correction at the end of this posting]

*’17%’ corrected to ‘13%’ on Sept. 22, 2016.

Unexpected outcomes

Here’s what happened, eventually, to the EWG and its work on sunscreens, from a June 23, 2020 posting “Sunscreens 2020 and the Environmental Working Group (EWG),”

There must be some sweet satisfaction or perhaps it’s better described as relief for the Environmental Working Group (EWG) now that sunscreens with metallic (zinc oxide and/or titanium dioxide) nanoparticles are gaining wide acceptance. (More about the history and politics EWG and metallic nanoparticles at the end of this posting.)

This acceptance has happened alongside growing concerns about oxybenzone, a sunscreen ingredient that EWG has long warned against. Oxybenzone has been banned from use in Hawaii due to environmental concerns (see my July 6, 2018 posting; scroll down about 40% of the way for specifics about Hawaii). Also, it is one of the common sunscreen ingredients for which the US Food and Drug Administration (FDA) is completing a safety review.

Today, zinc oxide and titanium dioxide metallic nanoparticles are being called minerals, as in, “mineral-based” sunscreens. They are categorized as physical sunscreens as opposed to chemical sunscreens.

A few thoughts on civil societies, business, and technological progress

The description of how sunscreens and other products with engineered nanoparticles were presented in misleading reports and articles is unfortunately not unusual where many civil society groups are concerned. (i found that very disillusioning.)

As for business and industry group, they use the same tactics.

Whether the topic is cigarette smoking, genetically modified organisms, engineered nanoparticles in sunscreens, etc. I keep reminding myself it’s best to consult more than one source and to remember that things change. All we’ve got to work with is the information at hand.

In the end, civil society groups provide an important function as do business and industrial groups. Trusting everything they say, is not a good idea. Something to remember when looking up organizations such as the Genetic Literacy Project and reading people like me.

China and nanosafety

I don’t often get information about China and its research into nanosafety issues so hats off to Jane Qiu at Nature Magazine for her Sept. 18, 2012 article (open access)  on the topic,

Here is a recipe for anxiety: take China’s poorly enforced chemical-safety regulations, add its tainted record on product safety and stir in the uncertain risks of a booming nanotechnology industry.

As an antidote to this uneasy mixture, the country should carry out more-extensive safety studies and improve regulatory oversight of synthetic nanomaterials, leading Chinese researchers said at the 6th International Conference on Nanotoxicology in Beijing this month. “This is the only way to maintain the competitiveness of China’s nanotechnology sector,” says Zhao Yuliang, deputy director of the Chinese Academy of Sciences’ National Center for Nano­science and Technology (NCNST) in Beijing. “We certainly don’t want safety issues to become a trade barrier for nano-based products.”

China has, as is widely known, invested heavily in nanotechnology research and is, increasingly, considered a major contender in this area. In common with many countries, China considers its research to be an investment in future economic prosperity. Also in common with many countries research into safety and environmental issues is not a particularly high priority,

China’s investment in nanotechnology has grown rapidly during the past decade, and its tally of patent applications in the field has surpassed those of Europe and the United States (see ‘Patent boom’). But only 3% of the investment is used for safety studies, says Zhao, compared with about 6% of federal nanotechnology funding in the United States. [emphasis mine] “The situation must be changed soon,” he says.

Although 6% by comparison with 3% must seem munificent, I don’t consider it to be a particularly substantive investment.

Qiu’s article does make mention of the 2009 industrial ‘accident’ where seven (eight according to my source in the European Respiratory Journal) workers were stricken with lung damage (two died) after working with materials containing nanoparticles. My July 26, 2011 posting noted this about the ‘accident’,

From the European Respiratory Journal article (ERJ September 1, 2009 vol. 34 no. 3 559-567, free access), Exposure to nanoparticles is related to pleural effusion, pulmonary fibrosis and granuloma,

A survey of the patients’ workplace was conducted. It measures ∼70 m2, has one door, no windows and one machine which is used to air spray materials, heat and dry boards. This machine has three atomising spray nozzles and one gas exhauster (a ventilation unit), which broke 5 months before the occurrence of the disease. The paste material used is an ivory white soft coating mixture of polyacrylic ester.

Eight workers (seven female and one male) were divided into two equal groups each working 8–12 h shifts. Using a spoon, the workers took the above coating material (room temperature) to the open-bottom pan of the machine, which automatically air-sprayed the coating material at the pressure of 100–120 Kpa onto polystyrene (PS) boards (organic glass), which can then be used in the printing and decorating industry. The PS board was heated and dried at 75–100°C, and the smoke produced in the process was cleared by the gas exhauster. In total, 6 kg of coating material was typically used each day. The PS board sizes varied from 0.5–1 m2 and ∼5,000 m2 were handled each workday. The workers had several tasks in the process including loading the soft coating material in the machine, as well as clipping, heating and handling the PS board. Each worker participated in all parts of this process.

Accumulated dust particles were found at the intake of the gas exhauster. During the 5 months preceding illness the door of the workspace was kept closed due to cold outdoor temperatures. The workers were all peasants near the factory, and had no knowledge of industrial hygiene and possible toxicity from the materials they worked with. The only personal protective equipment used on an occasional basis was cotton gauze masks. …

This provides some evidence for Qiu’s lede about “China’s poorly enforced chemical-safety regulations.”  Further in the article is acknowledgement of the occupational safety issue along with other safety issues,

Researchers at the meeting said that better safety testing was needed for products containing nanoparticles that can be absorbed by the body, such as food and cosmetics in which nanoparticles provide specific colours or textures. But occupational exposure among workers handling the materials may present the greatest risks: China’s workplace safety rules are not always implemented, and they set no specific limits for handling nanoparticles.

First, they need to characterize the hazards,

“The main challenge is to tease out what characteristics make some nanoparticles hazardous,” says Zhao. To address that question, Chinese researchers will next year join forces with colleagues in Europe, the United States and Brazil in a €13-million (US$17-million) project called Nanosolutions, to develop a nano-safety classification system based on material characteristics, toxicity studies and bioinformatics data. [emphasis mine] Initially focusing on 30 or so materials, such as carbon nanotubes, and nanoparticles of titanium dioxide and silver, the team will use high-throughput screening to identify the most toxic, and then investigate their biological effects in animal studies.

I’m glad to have learned more about China’s nanosafety efforts and look forward to hearing more about the Nanosolutions project as it progresses. Unfortunately, I’ve not been able to find any more information about this multi-country initiative, otherwise, I’d offer a link.

Misunderstanding the data or a failure to research? Georgia Straight article about nanoparticles

It’s good to see articles about nanotechnology. The recent, Tiny nanoparticles could be a big problem, article written by Alex Roslin for the Georgia Straight (July 21, 2011 online or July 21-28, 2011 paper edition) is the first I’ve seen on that topic in that particular newspaper. Unfortunately, there are  some curious bits of information included in the article, which render it, in my opinion, difficult to trust.

I do agree with Roslin that nanoparticles/nanomaterials could constitute a danger and there are a number of studies which indicate that, at the least, extreme caution in a number of cases should be taken if we choose to proceed with developing nanotechnology-enabled products.

One of my difficulties with the article is the information that has been left out. (Perhaps Roslin didn’t have time to properly research?) At the time (2009) I did read with much concern the reports Roslin mentions about the Chinese workers who were injured and/or died after working with nanomaterials. As Roslin points out,

Nanotech already appears to be affecting people’s health. In 2009, two Chinese factory workers died and another five were seriously injured in a plant that made paint containing nanoparticles.

The seven young female workers developed lung disease and rashes on their face and arms. Nanoparticles were found deep in the workers’ lungs.

“These cases arouse concern that long-term exposure to some nanoparticles without protective measures may be related to serious damage to human lungs,” wrote Chinese medical researchers in a 2009 study on the incident in the European Respiratory Journal.

Left undescribed by Roslin are the working conditions; the affected people were working in an unventilated room. From the European Respiratory Journal article (ERJ September 1, 2009 vol. 34 no. 3 559-567, free access), Exposure to nanoparticles is related to pleural effusion, pulmonary fibrosis and granuloma,

A survey of the patients’ workplace was conducted. It measures ∼70 m2, has one door, no windows and one machine which is used to air spray materials, heat and dry boards. This machine has three atomising spray nozzles and one gas exhauster (a ventilation unit), which broke 5 months before the occurrence of the disease. The paste material used is an ivory white soft coating mixture of polyacrylic ester.

Eight workers (seven female and one male) were divided into two equal groups each working 8–12 h shifts. Using a spoon, the workers took the above coating material (room temperature) to the open-bottom pan of the machine, which automatically air-sprayed the coating material at the pressure of 100–120 Kpa onto polystyrene (PS) boards (organic glass), which can then be used in the printing and decorating industry. The PS board was heated and dried at 75–100°C, and the smoke produced in the process was cleared by the gas exhauster. In total, 6 kg of coating material was typically used each day. The PS board sizes varied from 0.5–1 m2 and ∼5,000 m2 were handled each workday. The workers had several tasks in the process including loading the soft coating material in the machine, as well as clipping, heating and handling the PS board. Each worker participated in all parts of this process.

Accumulated dust particles were found at the intake of the gas exhauster. During the 5 months preceding illness the door of the workspace was kept closed due to cold outdoor temperatures. The workers were all peasants near the factory, and had no knowledge of industrial hygiene and possible toxicity from the materials they worked with. The only personal protective equipment used on an occasional basis was cotton gauze masks. According to the patients, there were often some flocculi produced during air spraying, which caused itching on their faces and arms. It is estimated that the airflow or turnover rates of indoor air would be very slow, or quiescent due to the lack of windows and the closed door. [emphases mine]

Here’s the full text from the researchers’ conclusion,

In conclusion, these cases arouse concern that long-term exposure to some nanoparticles without protective measures may be related to serious damage to human lungs. It is impossible to remove nanoparticles that have penetrated the cell and lodged in the cytoplasm and caryoplasm of pulmonary epithelial cells, or that have aggregated around the red blood cell membrane. Effective protective methods appear to be extremely important in terms of protecting exposed workers from illness caused by nanoparticles.

There is no question that serious issues about occupational health and safety with regards to nanomaterials were raised. But, we work with dangerous and hazardous materials all the time; precautions are necessary whether you’re working with hydrochloric acid or engineered nanoparticles. (There are naturally occurring nanoparticles too.)

Dr. Andrew Maynard (at the time he was the Chief Science Advisor for the Project on Emerging Nanotechnologies, today he is the Director of the University of Michigan’s Risk Science Center) on his 2020 Science blog wrote a number of posts dated Aug. 18, 2009 about this tragic industrial incident, including this one where he culled comments from six other researchers noting some of the difficulties the Chinese researchers experienced running a clinical study after the fact.

The material on silver nanoparticles and concerns about their use in consumer products and possible toxic consequences with their eventual appearance in the water supply seem unexceptionable to me. (Note:  I haven’t drilled down into the material and the writer cites studies unknown to me but they parallel information I’ve seen elsewhere).

The material on titanium dioxide as being asbestos-like was new to me, the only nanomaterial I’d previously heard described as being similar to asbestos is the long carbon nanotube. I am surprised Roslin didn’t mention that occupational health and safety research which is also quite disturbing, it’s especially surprising since Roslin does mention carbon nanotubes later in the article.

There is a Canadian expert, Dr. Claude Ostiguy, who consults internationally on the topic of nanotechnology and occupational health and safety. I wonder why he wasn’t consulted. (Note: He testified before Canada’s House of Commons Standing Committee on Health meeting in June 2010 on this topic. You can find more about this in my June 23, 2011 posting, Nanomaterials, toxicity, and Canada’s House of Commons Standing Committee on Health.)

Quoted quite liberally throughout the article is researcher, Dr.Robert Schiestl (professor of pathology and radiation oncology at the University of California at Los Angeles [UCLA]). This particular passage referencing Schiestl is a little disconcerting,

Schiestl said nanoparticles could also be helping to fuel a rise in the rates of some cancers. He wouldn’t make a link with any specific kind of cancer, but data from the U.S. National Cancer Institute show that kidney and renal-pelvis cancer rates rose 24 percent between 2000 and 2007 in the U.S., while the rates for melanoma of the skin went up 29 percent and thyroid cancer rose 54 percent.

Since Schiestl isn’t linking the nanoparticles to any specific cancers, why mention those statistics? Using that kind of logic I could theorize that the increase in the number and use of cell phones (mobiles) may have something to do with these cancers. Perhaps organic food has caused this increase? You see the problem?

As for the number of nanotechnology-enabled products in use, I’m not sure why Roslin chose to cite the Project on Emerging Nanotechnologies’ inventory which is not scrutinized, i. e., anyone can register any product as nanotechnology-enabled. The writer also mentioned a Canadian inventory listing over 1600 products  cited in an ETC Group report, The Big Downturn? Nanogeopolitics,

Has anyone ever seen this inventory? I’ve been chasing it for years and the only time the Canadian government reports on this inventory is in the Organization for Economic Cooperation and Development (OECD) report (cited by the ETC Group [no. 79 in their list of references] and noted in both my Feb. 1, 2011 posting and my April 12, 2010 posting). Here’s the OECD report, if you’d like to see it for yourself. The top three questions I keep asking myself is where is the report/inventory, how did they determine their terms of reference, and why don’t Canadian taxpayers have easy access to it? I’d best return to my main topic.

As for the material Roslin offers about nanosunscreens I was surprised given the tenor of the article to see that the Environmental Working Group (EWG) was listed as an information source since they recommend mineral sunscreens containing nanoscale ingredients such as titanium dioxide and/or zinc oxide as preferable to sunscreens containing hormone disruptors.  From the EWG page on sunscreens and nanomaterials,

Sunscreen makers offer mineral and non-mineral formulations, as well as products that combine both mineral and non-mineral active ingredients. Mineral formulations incorporate zinc oxide or titanium dioxide in nano- and micro-sized particles that can be toxic if they penetrate the skin. Most studies show that these ingredients do not penetrate through skin to the bloodstream, but research continues. These constitute one in five sunscreens on the market in 2010 and offer strong UVA protection that is rare in non-mineral sunscreens.

The most common ingredients in non-mineral sunscreens are oxybenzone, octisalate, octinoxate, and avobenzone found in 65, 58, 57, and 56 percent of all non-mineral sunscreens on the market, respectively. The most common, oxybenzone, can trigger allergic reactions, is a potential hormone disruptor and penetrates the skin in relatively large amounts. Some experts caution that it should not be used on children. Three of every five sunscreens rated by EWG are non-mineral, and one in five sunscreens combines both mineral and non-mineral active ingredients.

EWG reviewed the scientific literature on hazards and efficacy (UVB and UVA protection) for all active ingredients approved in the U.S. Though no ingredient is without hazard or perfectly effective, on balance our ratings tend to favor mineral sunscreens because of their low capacity to penetrate the skin and the superior UVA protection they offer. [emphasis mine]

(I did find some information (very little) about Health Canada and sunscreens which I discuss in June 3, 2011 posting [if you’re impatient, scroll down about 1/2 way].)

There was some mention of Health Canada in Roslin’s article but no mention of last year’s public consultation, although to be fair, it seemed a clandestine operation. (My latest update on the Health Canada public consultation about a definition for nanomaterials is May 27, 2011.)

I find some aspects of the article puzzling as Roslin is an award-winning investigative reporter. From the kitco bio page,

Alex Roslin is a leading Canadian investigative journalist and active trader based in Montreal. He has won a Canadian Association of Journalists award for investigative reporting and is a five-time nominee for investigative and writing prizes from the CAJ and the National Magazine Awards. He has worked on major investigations for Canada’s premier investigative television program, the fifth estate, and the CBC’s Disclosure program. His writing has appeared in Technical Analysis of Stocks & Commodities, The Financial Post, Toronto Star and Montreal Gazette. He regularly writes about investing for The Montreal Gazette.

I notice there’s no mention of writing in either science or health matters so I imagine this is an early stage piece in this aspect of Roslin’s career, which may explain some of the leaps in logic and misleading information. Happily, I did learn a few things from reading the article and while I don’t trust much of the information in it, I will investigate further as time permits.

In general, I found the tenor of the article more alarmist than informational and I’m sorry about that as I would like to see more information being shared and, ultimately, public discussion in Canada about nanotechnology and other emerging technologies.