Michael Berger wrote an August 17, 2025 Nanowerk spotlight article on proposed research into the use of graphene as a protection against malaria carrying mosquitoes, Note: Links have been removed,

Malaria continues to resist elimination efforts, even as vaccines and treatments become easier to access. Despite substantial progress, the disease remains a serious global threat. According to the World Health Organization, in 2023 there were an estimated 597,000 malaria-related deaths and 263 million cases worldwide. Preventive measures such as insecticide-treated bed nets and indoor spraying remain key strategies, and diagnostic testing and treatments are essential for managing infections.

Yet each tool faces limits. Mosquitoes are developing resistance to insecticides. Parasites are evolving resistance to treatments. Diagnostics often require lab settings or fail to detect infections early or at low levels. Malaria must be managed at many points—from the mosquito bite to parasite growth to detection—but the current tools are not equally effective at every stage.

Materials science is now stepping into this space with a new class of engineered substances: two-dimensional (2D) materials, particularly graphene and its variants. Graphene is a single sheet of carbon atoms arranged in a hexagonal pattern, known for its exceptional strength, electrical conductivity, and chemical reactivity. These properties make it promising for applications that require both sensitivity and selectivity, such as detecting tiny amounts of biomolecules or blocking microscopic particles.

Berger’s August 17, 2025 article delves into further detail, Note: A link has been removed,

A comprehensive review published in Advanced NanoBiomed Research (“The Comprehensive Roadmap Toward Malaria Elimination Using Graphene and its Promising 2D Analogs”) outlines how graphene and similar materials could be systematically applied across multiple stages of malaria control.

The authors present a structured roadmap covering synthesis methods, biological interactions, safety issues, and potential for use in both diagnosis and prevention. Their approach is not to suggest a single cure-all, but to identify specific material properties that could address long-standing weaknesses in current malaria tools.

The paper begins by describing how graphene and its common derivatives — including graphene oxide (GO), reduced graphene oxide (rGO), and graphene quantum dots (GQDs) — can be manufactured using physical, chemical, or biological methods. Physical methods include mechanical exfoliation and chemical vapor deposition, which yield high-purity graphene sheets. Chemical methods, such as Hummers’ method, oxidize graphite to produce GO, a more water-dispersible form that is easier to work with in biological environments. Biological or “green” methods use plant extracts or microbes as reducing agents to avoid toxic solvents, and these are seen as more scalable and biocompatible for medical applications. Each method has trade-offs in cost, quality, and environmental impact.

Once produced, graphene-based materials can interact with malaria parasites, mosquitoes, or infected blood cells in ways that potentially disrupt the disease process. The authors identify three primary intervention points: prevention, parasite inhibition, and diagnosis.

In terms of prevention, graphene’s impermeability makes it an effective barrier material. When applied as a coating on fabrics or films, it can block mosquito bites by physically resisting the insect’s proboscis and masking human scent cues such as carbon dioxide and lactic acid. Laboratory studies have demonstrated that multilayer GO coatings on the skin prevent mosquitoes from locating and piercing the surface, reducing bite risk without using chemicals. These barrier films are flexible and can be integrated into clothing or wearable devices. Because the films are stable and resistant to wear, they offer longer-lasting protection than chemical repellents.

The review also discusses using GQDs as larvicides, since these nanoscale particles can penetrate mosquito larvae and disrupt their development. Their small size allows them to pass through biological membranes and interfere with cell function, though the exact mechanism remains under study.

The second application area is inhibition of parasite development. After a person is bitten, the malaria parasite enters the bloodstream and invades red blood cells. GO nanosheets have shown the ability to bind to the parasite’s outer membrane or to essential nutrients in the blood, physically blocking the parasite’s access to the cell. In vitro experiments suggest that GO can capture or neutralize the parasite before it completes its life cycle.
Some graphene derivatives can interfere with protein transport or nutrient absorption, making the environment inside the host less favorable to the parasite. These materials could potentially be delivered through injectable suspensions or oral carriers, though this application remains in early experimental phases.

One of the most promising areas for using graphene in malaria control is early diagnosis. Accurate detection is critical for timely treatment and for preventing the spread of infection, especially in areas with limited medical infrastructure. Traditional diagnostic tools, such as rapid tests and blood smears, often miss low-level infections or require trained personnel and laboratory settings. Graphene offers a way to build more sensitive, portable, and reliable detection devices.

Graphene’s usefulness in sensing comes from its structure. Because it is only one atom thick, any molecule that lands on its surface can quickly alter its electrical or optical properties. This makes it especially good at detecting very small amounts of biological material — such as the proteins, DNA, or altered red blood cells that signal a malaria infection.

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If you are interested in the possibilities that graphene offers, Berger’s August 17, 2025 article is well worth reading in its entirety.

Here’s a link to and a citation for the paper,

The Comprehensive Roadmap Toward Malaria Elimination Using Graphene and its Promising 2D Analogs by Fangzhou He, George Junior, Rajashree Konar, Yuanding Huang, Ke Zhang, Lijing Ke, Meng Niu, Boon Tong Goh, Amine El Moutaouakil, Gilbert Daniel Nessim, Mohamed Belmoubarik, Weng Kung Peng. Advanced NanoBiomed Research Volume 5, Issue 8 August 2025 2300130 DOI: https://doi.org/10.1002/anbr.202300130 First published online: 15 March 2024

This paper is open access.