Tag Archives: Jim Hanlon

#BCTECH: being at the Summit (Jan. 18-19, 2016)

The NanoAssemblr™ Platform

The microfluidic approach to particle formulation is at the heart of the NanoAssemblr Platform. This well-controlled process mediates bottom-up self-assembly of nanoparticles with reproducible sizes and low polydispersity. Users can control size by process and composition, and adjust parameters such as mixing ratios, flow rate and lipid composition in order to fine-tune nanoparticle size, encapsulation efficiency and much more. The system technology enables manufacturing scale-up through microfluidic reactor parallelization similar to the arraying of transistors on an integrated chip. Superior design ensures that the platform is fast and easy to use with a software controlled manufacturing process. This usability allows for the simplified transfer of manufacturing protocols between sites, which accelerates development, reduces waste and ultimately saves money. Precision NanoSystems’ flagship product is the NanoAssemblr™ Benchtop Instrument, designed for rapid prototyping of novel nanoparticles. Preparation time on the system is streamlined to approximately one minute, with the ability to complete 30 formulations per day in the hands of any user.

The company is located on property known as the Endowment Lands or, more familiarly, the University of British Columbia (UBC).

A few comments before moving on, being able to standardize the production of medicine-bearing nanoparticles is a tremendous step forward which is going to help scientists dealing with other issues. Despite all the talk in the media about delivering nanoparticles with medication directly to diseased cells, there are transport issues: (1) getting the medicine to the right location/organ and (2) getting the medicine into the cell. My Jan. 12, 2016 posting featured a project with Malaysian scientists and a team at Harvard University who are tackling the transport and other nanomedicine) issues as they relate to the lung. As well, I have a Nov. 26, 2015 posting which explores a controversy about nanoparticles getting past the ‘cell walls’ into the nucleus of the cell.

The next ‘nano’ booths were,

4D Labs located at Simon Fraser University (SFU) was initially hailed as a nanotechnology facility but these days they’re touting themselves as an ‘advanced materials’ facility. Same thing, different branding.

They advertise services including hands-on training for technology companies and academics. There is a nanoimaging facility and nanofabrication facility, amongst others.

I spoke with their operations manager, Nathaniel Sieb who mentioned a few of the local companies that use their facilities. (1) Nanotech Security (featured here most recently in a Dec. 29, 2015 post), an SFU spinoff company, does some of their anticounterfeiting research work at 4D Labs. (2) Switch Materials (a smart window company, electrochromic windows if memory serves) also uses the facilities. It is Neil Branda’s (4D Labs Executive Director) company and I have been waiting impatiently (my May 14, 2010 post was my first one about Switch) for either his or someone else’s electrochromic windows (they could eliminate or reduce the need for air conditioning during the hotter periods and reduce the need for heat in the colder periods) to come to market. Seib tells me, I’ll have to wait longer for Switch. (3) A graduate student was presenting his work at the booth, a handheld diagnostic device that can be attached to a smartphone to transmit data to the cloud. While the first application is for diabetics, there are many other possibilities. Unfortunately, glucose means you need to produce blood for the test when I suggested my preference for saliva the student explained some of the difficulties. Apparently, your saliva changes dynamically and frequently and something as simple as taking a sip of orange juice could result in a false reading. Our conversation (mine, Seib’s and the student’s) also drifted over into the difficulties of bringing products to market. Sadly, we were not able to solve that problem in our 10 minute conversation.

FPInnovations is a scientific research centre and network for the forestry sector. They had a display near their booth which was like walking into a peculiar forest (I was charmed). The contrast with the less imaginative approaches all around was striking.

FPInnovation helped to develop cellulose nanocrystals (CNC), then called nanocrystalline cellulose (NCC), and I was hoping to be updated about CNC and about the spinoff company Celluforce. The researcher I spoke to was from Sweden and his specialty was business development. He didn’t know much about CNC in Canada and when I commented on how active Sweden has been its pursuit of a CNC application, he noted Finland has been the most active. The researcher noted that making the new materials being derived from the forest, such as CNC, affordable and easily produced for use in applications that have yet to be developed are all necessities and challenges. He mentioned that cultural changes also need to take place. Canadians are accustomed to slicing away and discarding most of the tree instead of using as much of it as possible. We also need to move beyond the construction and pulp & paper sectors (my Feb. 15, 2012 posting featured nanocellulose research in Sweden where sludge was the base material).

Other interests at the Summit

I visited:

“The Wearable Lower Limb Anthropomorphic Exoskeleton (WLLAE) – a lightweight, battery-operated and ergonomic robotic system to help those with mobility issues improve their lives. The exoskeleton features joints and links that correspond to those of a human body and sync with motion. SFU has designed, manufactured and tested a proof-of-concept prototype and the current version can mimic all the motions of hip joints.” The researchers (Siamak Arzanpour and Edward Park) pointed out that the ability to mimic all the motions of the hip is a big difference between their system and others which only allow the leg to move forward or back. They rushed the last couple of months to get this system ready for the Summit. In fact, they received their patent for the system the night before (Jan. 17, 2016) the Summit opened.

It’s the least imposing of the exoskeletons I’ve seen (there’s a description of one of the first successful exoskeletons in a May 20, 2014 posting; if you scroll down to the end you’ll see an update about the device’s unveiling at the 2014 World Cup [soccer/football] in Brazil).

Unfortunately, there aren’t any pictures of WLLAE yet and the proof-of-concept version may differ significantly from the final version. This system could be used to help people regain movement (paralysis/frail seniors) and I believe there’s a possibility it could be used to enhance human performance (soldiers/athletes). The researchers still have some significant hoops to jump before getting to the human clinical trial stage. They need to refine their apparatus, ensure that it can be safely operated, and further develop the interface between human and machine. I believe WLLAE is considered a neuroprosthetic device. While it’s not a fake leg or arm, it enables movement (prosthetic) and it operates on brain waves (neuro). It’s a very exciting area of research, consequently, there’s a lot of international competition. [ETA January 3, 2024: I’m pretty sure I got the neuroprosthetic part wrong]

Delightfully, after losing contact for a while, I reestablished it with the folks (Sean Lee, Head External Relations and Jim Hanlon, Chief Administrative Officer) at TRIUMF (Canada’s national laboratory for particle and nuclear physics). It’s a consortium of 19 Canadian research institutions (12 full members and seven associate members).

It’s a little disappointing that TRIUMF wasn’t featured in the opening for the Summit since the institution houses theoretical, experimental, and applied science work. It’s a major BC (and Canada) science and technology success story. My latest post (July 16, 2015) about their work featured researchers from California (US) using the TRIUMF cyclotron for imaging nanoscale materials and, on the more practical side, there’s a Mar. 6, 2015 posting about their breakthrough for producing nuclear material-free medical isotopes. Plus, Maclean’s Magazine ran a Jan. 3, 2016 article by Kate Lunau profiling an ‘art/science’ project that took place at TRIUMF (Note: Links have been removed),

“It’s not every day that most people get to peek inside a world-class particle physics lab, where scientists probe deep mysteries of the universe. In September [2015], Vancouver’s TRIUMF—home to the world’s biggest cyclotron, a type of particle accelerator—opened its doors to professional and amateur photographers, part of an event called Global Physics Photowalk 2015. (Eight labs around the world participated, including CERN [European particle physics laboratory], in Geneva, where the Higgs boson particle was famously discovered.)”

Here’s the local (Vancouver) jury’s pick for the winning image (from the Nov. 4, 2015 posting [Winning Photographs Revealed] by Alexis Fong on the TRIUMF website),

Caption: DESCANT (at TRIUMF) neutron detector array composed of 70 hexagonal detectors Credit: Pamela Joe McFarlane

With all those hexagons and a spherical shape, the DESCANT looks like a ‘buckyball’ or buckminsterfullerene or C60 to me.

I hope the next Summit features TRIUMF and/or some other endeavours which exemplify, Science, Technology, and Creativity in British Columbia and Canada.

Onto the last booth,

MITACS was originally one of the Canadian federal government’s Network Centres for Excellence projects. It was focused on mathematics, networking, and innovation but once the money ran out the organization took a turn. These days, it’s describing itself as (from their About page) “a national, not-for-profit organization that has designed and delivered research and training programs in Canada for 15 years. Working with 60 universities, thousands of companies, and both federal and provincial governments, we build partnerships that support industrial and social innovation in Canada.”Their Jan. 19, 2016 news release (coincidental with the #BCTECH Summit, Jan. 18 – 19, 2016?) features a new report about improving international investment in Canada,”Opportunities to improve Canada’s attractiveness for R&D investment were identified:1.Canada needs to better incentivize R&D by rebalancing direct and indirect support measures
2.Canada requires a coordinated, client-centric approach to incentivizing R&D

3.Canada needs to invest in training programs that grow the knowledge economy”

Oddly, entrepreneurial/corporate/business types never have a problem with government spending when the money is coming to them; it’s only a problem when it’s social services.

Back to MITACS, one of their more interesting (to me) projects was announced at the 2015 Canadian Science Policy Conference. MITACS has inaugurated a Canadian Science Policy Fellowships programme which in its first year (pilot) will see up up to 10 academics applying their expertise to policy-making while embedded in various federal government agencies. I don’t believe anything similar has occurred here in Canada although, if memory serves, the Brits have a similar programme.

Finally, I offer kudos to Sherry Zhao, MITACS Business Development Specialist, the only person to ask me how her organization might benefit my business. Admittedly I didn’t talk to a lot of people but it’s striking to me that at an ‘innovation and business’ tech summit, only one person approached me about doing business. Of course, I’m not a male aged between 25 and 55. So, extra kudos to Sherry Zhao and MITACS.

Christy Clark (Premier of British Columbia), in her opening comments, stated 2800 (they were expecting about 1000) had signed up for the #BCTECH Summit. I haven’t been able to verify that number or get other additional information, e.g., business deals, research breakthroughs, etc. announced at the Summit. Regardless, it was exciting to attend and find out about the latest and greatest on the BC scene.

I wish all the participants great and good luck and look forward to next year’s where perhaps we’ll here about how the province plans to help with the ‘manufacturing middle’ issue. For new products you need to have facilities capable of reproducing your devices at a speed that satisfies your customers; see my Feb. 10, 2014 post featuring a report on this and other similar issues from the US General Accountability Office.

*’BCTECH Summit 2016′ link added Jan. 21, 2016.

TRIUMF announces both an interim director and an unusual job sharing plan with Japan

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A July 17, 2013 TRIUMF news release announces a new interim structure (CEO? and name change?) and an international search for a permanent replacement while they wish current director Nigel Lockyer well as he dances out the door to his new job as director of the US Fermi National Accelerator Laboratory in Chicago, Illinois,

TRIUMF’s Board of Management today announced plans for interim leadership of the laboratory. Present director Nigel S. Lockyer will be leaving TRIUMF and headed to the U.S. Fermi National Accelerator Laboratory as its new director effective September 3, 2013. Interim leadership will be provided by the Board and a team of current senior staff.

…

In its discussions, the Board reviewed the following considerations:

+ The laboratory’s near-term activities and plans are well-defined and
publicly declared in its Five-Year Plan 2010-2015;
+ Effective stewardship of the laboratory in this interim period requires
familiarity and experience with TRIUMF;
+ The senior management team of the laboratory is successful and efficient;
and
+ The Board of Management, representing the university owners of TRIUMF, is
ultimately responsible for the laboratory and its operations and the
fulfillment of the laboratory’s mission.

To achieve these objectives, an interim-leadership structure composed of a management team, direct participation by members of the Board, and a new President and CEO of TRIUMF Accelerators, Inc. will be implemented on August 1, 2013 (thereby providing one-month overlap with the present Laboratory Director).

The Board of Management will exercise oversight and control of TRIUMF through weekly meetings between laboratory management and the Chair of the Finance Committee of the Board and monthly meetings between laboratory management and the Chair of the Board.

The laboratory will manage day-to-day operations using a team of existing senior staff. The team will consist of three elements:

1. Scientific and Engineering Leadership Team (including the Heads of the Science, Engineering, Nuclear Medicine, and Accelerator Divisions);
2. Administrative Leadership Team (including the Chief Financial Officer; the Head of the Business and Administration Division; the Manager, Environment, Health and Safety; and the Head of Strategic Planning and Communication); and
3. An Interim Chief Executive Officer / Chief Administrative Officer (CEO/CAO) who will have signing authority for TRIUMF and will be responsible for the smooth operation and performance of the teams. This role will be filled by Jim Hanlon who will be accountable to the Board on a day-to-day
basis for the laboratory. Jim is currently Head of the Business & Administration Division and Secretary to the TRIUMF Board of Management.

The new interim President and CEO of TRIUMF Accelerators, Inc. will be Jim Hanlon. [emphasis mine] Other officers remain as they are. The interim and transitional arrangement will be operative for six months, or extended following review, until the next director is appointed.
…

With regard to selecting a new director of the laboratory, the chair of the Search Committee has been identified and the full committee is being convened. The international search will be launched by August 1.

This is fascinating and it’s nice to have a name for the new ‘head poobah’ although they’ve decided to restructure in a rather **unexpected and dramatic fashion with the decision to appoint a temporary Chief Executive Officer (CEO) and President, not a director as was Lockyer. Plus they seem to have changed the organization’s name in **the news release, TRIUMF Accelerators, Inc., as opposed to TRIUMF; Canada’s National Laboratory for Particle and Nuclear Physics. Oddly, the name change is not reflected on the website as of July 18, 2013 11:45 PDT nor is it officially announced in the news release.

I did speculate as to some of the issues that might arise when a leader departs in a June 21, 2013 posting where I used Tim Meyer (Head, Strategic Planning & Communications) as an example and described some of the issues that might arise regardless of whom is chosen from an internal pool for an interim position but I never anticipated this dramatic shift to a structure that mimics a corporation rather than a scientific enterprise. (It seems to me their appointee, Jim Hanlon, heads the Business & Administration Division and is Secretary to the Board of Management is in the unenviable position of not having much authority, other than signing authority, in a situation where he carries a lot of responsibility.)

Assuming that this is a permanent change in structure, they will be searching for a president and CEO not a director which along with the name change suggests that the emphasis will be on business qualifications as much as, or perhaps more so, than on research qualifications. *Coincidentally or not, the new, as of July 15, 2013, Minister of State for Science and Technology, Gary Rickford has an MBA (Masters of Business Administration) in addition to his nursing qualifications and legal degree. I covered this latest cabinet shuffle and the change to the junior ministry (Sci & Tech) and its parent ministry, Industry Canada, in my July 17, 2012 posting.)

Given the Canadian federal government’s appetite for commodifying scientific research and imposing business models on the research community, this seems like a smart and strategic move on TRIUMF’s part. (For an example of the Harper government’s appetite, I wrote about Canada’s National Research Council and its change to a business-oriented focus in my May 13, 2012 posting and May 22, 2013 posting.)

I note this change to a corporate name and structure comes from within the science community and is not being imposed by the government. It seems that as scientists see how the wind is blowing they will turn direction. Of course, that’s pretty standard behaviour in any sector. What makes this situation at TRIUMF particularly interesting is the implication for the future as young scientists are likely to increasingly adopt business attitudes to their work. Since business is primarily about making money and the last time we encouraged youth to pursue money at all costs we ended up with at least two economic meltdowns and a generation of investment bankers, we are likely to run short (again) of critically needed skills in areas that **don’t promise ‘a fast buck’.

Finally, here’s my bit about a unique job sharing plan between TRIUMF (issued prior to the name change?) and a laboratory in Japan. From a July 11, 2013 TRIUMF news release,

In an unusual alliance between TRIUMF, Canada’s national laboratory for nuclear and particle physics, and the Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU) in Japan, a long-term joint research position has been created in order to recruit, develop, and
support a world-leading scientist in two countries. The catch? After working for the first four years with 75% of his time in Japan and 25% in Canada, the candidate will choose which laboratory’s long-term job offer to accept. American physicist Dr. Mark Hartz has been selected for this
high-stakes competition and in five years will be choosing his long-term home in Tokyo or Vancouver.

From either side of the Pacific Ocean, there will continue to be a great demand for Hartz. He has been appointed as assistant professor and is expected to carry out the full range of duties of a grant tenure track research scientist at both Kavli IPMU and TRIUMF. Additionally, he will serve on internal committees and represent both institutes at the national and international level. His cross-cultural and cross-laboratory experiences will be a great benefit for both Kavli IPMU and TRIUMF.

Dr. Nigel S. Lockyer, director of TRIUMF, acknowledged the rarity and significance of Hartz’s role. Lockyer said, “We need more competitive, cross-border positions like this to enrich and strengthen top talent. I’m delighted that Japan agrees that Hartz is worth fighting for, and yet I’m confident that in the long term Canada is the right place for him and his world-class research ambitions.”

Dr. Hitoshi Murayama, director of Kavli IPMU, said, “Mark is a tremendous addition to our team and will help expand our institutional role in the Japanese flagship T2K neutrino experiment. Once he comes to Kavli IPMU and sees our fantastic environment with interdisciplinary interactions with
astronomers and mathematicians, I have no doubt that he will settle down here. We already have a great track record of keeping our non-Japanese scientists happy and productive.”

In recent years, Hartz experienced the enormous benefits of global collaboration through research at the Tokai to Kamioka (T2K) neutrino experiment-an international investigation into the behaviour of neutrinos as they travel from one location to another, where he led national efforts to develop beamline monitors and analysis specific to the experiment. With his advanced technical and engineering background, Hartz is an ideal candidate for this cross-laboratory role. He will continue to focus his tenure on the T2K collaboration and is expected to build a strong T2K experimental group at Kavli IPMU.

“The T2K experiment is a textbook example of scientists working across borders to drive new discoveries and pursue the best science,” said Hartz. “This joint position is a brilliant opportunity to work with research communities and give momentum to those interactions. Although national
borders are invisible to the scientist in me, I am curious to see where I’ll end up in five years!”

As a post-doctoral fellow at both York University and the University of Toronto, Hartz gained extensive experience with the T2K Optical Transition detector and led both the beam analysis and Near Detector to Far Detector Extrapolation analysis groups. He completed detailed predictions of neutrino beam properties prior to the neutrino changing its form in a phenomenon called “neutrino oscillation”. Additionally, Hartz developed sophisticated analysis tools to constrain the neutrino beam flux-an important element for analyzing the oscillations of neutrinos.

Other than being confused as to whether Hartz is making his choice of laboratory and country after four years or five, I do find this to be an innovative approach to recruiting researchers and I see advantages for both the researchers and the labs. I am curious as to why it’s a 75%/25% split in favour of the Kavli Institute (PMU) in Japan. Does it have something to do with initiating this unique opportunity? O perhaps since the researcher is Canadian and more time is needed in Japan so he might acclimate and make a more informed decision?

Regardless, bravo to both the Kavli Institute (PMU) and TRIUMF for taking a bold approach to attracting exciting researchers to their respective institutions.

* Opening paranthesis removed on July 19, 2013.

** ‘and’ removed, ‘the’ added’, and ‘didn’t’ changed to ‘don’t’ on Aug. 1, 2013

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Tag Archives: Jim Hanlon

#BCTECH: being at the Summit (Jan. 18-19, 2016)

The NanoAssemblr™ Platform

TRIUMF announces both an interim director and an unusual job sharing plan with Japan