Tag Archives: José Tadeu Arantes

It’s all about the cellulose and the graphite: using fallen leaves as the basis for medical and laboratory sensors

Caption: Sensor printed on leaf by CO2 laser. Credit: Bruno Janegitz

A May 9, 2024 news item on phys.org announces work which makes use of fallen leaves, Note: A link has been removed,

Fabrication of sensors by 3D printing combines speed, freedom of design, and the possibility of using waste as a substrate. Various results have been obtained in a circular economy mode, whereby residues usually thrown away are instead used as low-cost resources.

A highly creative solution involving the printing of electrochemical sensors on fallen tree leaves has now been presented by a team of researchers in Brazil led by Bruno Janegitz, a professor at the Federal University of São Carlos (UFSCar) and head of its Laboratory for Sensors, Nanomedicines, and Nanostructured Materials (LSNANO), and Thiago Paixão, a professor at the University of São Paulo (USP) and head of its Electronic Tongues and Chemical Sensors Lab (L2ESQ).

A May 8, 2024 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) press release (also on EurekAlert but published May 9, 2024) by José Tadeu Arantes, Note: Links have been removed,

The initiative was supported by FAPESP and highlighted in an article published in the journal ACS Sustainable Chemistry & Engineering.

“We used a CO2 [carbon dioxide] laser to print the design of interest on a leaf by means of pyrolysis and carbonization. We thereby obtained an electrochemical sensor for use in determining levels of dopamine and paracetamol. It’s very easy to operate. A drop of the solution containing one of these compounds is placed on the sensor, and the potentiostat to which it’s coupled displays the concentration,” Janegitz said.

Simply put, the laser beam burns the leaf in a pyrolytic process that converts its cellulose into graphite [emphasis mine], and the graphite body is printed on the leaf in a shape suited to functioning as a sensor. During the fabrication process, the parameters of the CO2 laser, including laser power, pyrolysis scan rate and scan gap, are systematically adjusted to achieve optimal outcomes.

“The sensors were characterized by morphological and physicochemical methods, permitting exhaustive exploration of the novel carbonized surface generated on the leaves,” Janegitz said.

“Furthermore, the applicability of the sensors was confirmed by tests involving the detection of dopamine and paracetamol in biological and pharmaceutical samples. For dopamine, the system proved efficient in a linear range of 10–1,200 micromoles per liter, with a detection limit of 1.1 micromole per liter. For paracetamol, the system worked well in a linear range of 5-100 micromoles per liter, with a detection limit of 0.76.”

In the tests involving dopamine and paracetamol, conducted as proof of concept, the electrochemical sensors derived from fallen tree leaves attained a satisfactory analytical performance and noteworthy reproducibility, highlighting their potential as an alternative to conventional substrates.

Substituting fallen tree leaves for conventional materials yields significant gains in terms of cost-cutting and above all environmental sustainability. “The leaves would have been incinerated, or at best composted. Instead, they were used as a substrate for high value-added devices in a major advancement for the fabrication of next-generation electrochemical sensors,” Janegitz said. 

There’s also this, “The Agency FAPESP licenses news via Creative Commons (CC-BY-NC-ND) so that they can be republished free of charge and in a simple way by other digital or printed vehicles.”

Here’s a link to and a citation for the paper,

Green Fabrication and Analytical Application of Disposable Carbon Electrodes Made from Fallen Tree Leaves Using a CO2Laser by Rodrigo Vieira Blasques, Jéssica Rocha Camargo, William Barros Veloso, Gabriel Negrão Meloni, Fernando Amaral Fernandes, Beatriz Fernandes Germinare, Luiz Ricardo Guterres e Silva, Abner de Siervo, Thiago Regis Longo Cesar Paixão, and Bruno Campos Janegitz. ACS Sustainable Chem. Eng. 2024, 12, 8, 3061–3072 DOI: https://doi.org/10.1021/acssuschemeng.3c06526 Publication Date: February 13, 2024 Copyright © 2024 American Chemical Society

This paper is behind a paywall.

Georges Canguilhem’s influence on life sciences philosophy and ‘it’s all about Kant’

This July 5, 2023 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) press release by José Tadeu Arantes (also on EurekAlert but published on July 3, 2023) slow walks us through a listing of French intellectuals and some history (which I enjoyed) before making a revelation,

The constitution of the World Health Organization (WHO) defines health as “a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity”. The definition dates from the 1940s, but even then the thinking behind it was hardly novel. Similar concepts can be found in antiquity, in Eastern as well as Western societies, but in Europe, the cradle of Western culture, the view that mental well-being was part of health enjoyed little prestige in the eighteenth and nineteenth centuries owing to a reductionist understanding of disease as strictly somatic (relating only to the body). This outlook eventually began to be questioned. One of its leading critics in the twentieth century was French philosopher and physician Georges Canguilhem (1904-1995).

A disciple of Gaston Bachelard (1884-1962), a colleague of Jean-Paul Sartre (1905-1980), Paul Nizan (1905-1940) and Raymond Aron (1905-1983), and a major influence on Michel Foucault (1926-1984), Canguilhem was one of the foremost French intellectuals of the postwar years. Jacques Lacan (1901-1981), Gilles Deleuze (1925-1995) and Jacques Derrida (1930-2004) were among the thinkers who took inspiration from his ideas.

Canguilhem began studying medicine in the mid-thirties and earned his medical doctorate in 1943, by which time he had already taught philosophy in high schools for many years (having qualified in 1927). Another significant tack in his life course occurred during World War Two. He had long been both a pacifist and an antifascist. Following the French surrender in 1940, he refused to continue teaching under the Vichy regime and joined the Resistance, fighting with the rural guerrillas of the Maquis. In this historically and politically complex period, he apparently set out to train as a physician in order to have practical experience as well as book learning and to work on the history of the life sciences. He was awarded the Croix de Guerre and the Médaille da la Résistance for organizing a field hospital while under attack in the Auvergne.

In an article published in the journal History and Philosophy of the Life Sciences, Emiliano Sfara, who has a PhD in philosophy from the University of Montpellier and was a postdoctoral fellow at the University of São Paulo (USP) in Brazil from 2018 to 2022, argues that Canguilhem’s concepts of “technique”, “technical activity” and “practice” derived from Immanuel Kant’s Critique of Judgment (1790) and influenced Canguilhem’s decision to study medicine.

“Earlier historiographical research showed how Kant influenced Canguilhem, especially the concept of ‘knowledge’ developed in Kant’s Critique of Pure Reason as the unification of heterogeneous data by an organizing intellect, and the idea of the ‘organism’ as a totality of interdependent and interacting parts, inspired by the Critique of Judgment. I tried to show in the article the importance, and roots in Kant, of a third cluster of ideas relating to the concept of ‘technique’ in Canguilhem’s work, beginning in mid-thirties,” said Sfara, currently a researcher at the National Institute of Science and Technology for Interdisciplinary and Transdisciplinary Studies in Ecology and Evolution (INCT IN-TREE), hosted by the Federal University of Bahia (UFBA).

“Section 43 of Kant’s Critique of Judgment makes a distinction between technical capacity and science as a theoretical faculty. Technique is the subject’s concrete practice operating in a certain context, a vital movement of construction or manufacturing of objects and tools that enable a person to live in their environment. This is not reducible to science. Analogously, Canguilhem postulates that science is posterior to technique. Practice comes first; theory arises later. This movement is evident in art. True, the artist starts out with a project. But the development of the artwork isn’t confined to the project, which is reconstructed as the process unfolds. This practical element of the subject’s interaction with the environment, which has its roots in Kant’s theories, was very important to the evolution of Canguilhem’s thought. It even influenced his decision to study medicine, as well as the conception of medicine he developed.”

Sfara explained that while Canguilhem espoused the values of the Parti Radical in his youth, in the mid-thirties he moved left, without becoming a pro-Soviet Stalinist. Later on, according to some scholars who knew him and are still active (such as the Moroccan philosopher and mathematician Hourya Benis Sinaceur), Canguilhem gave primacy to the egalitarian principles symbolized by the French Republic’s motto Liberté, Egalité, Fraternité.

His main contributions were to medicine and philosophy of science. His most important work, The Normal and the Pathological (1966), is basically an expansion of his 1943 doctoral thesis. “In his original thesis, Canguilhem broke with part of eighteenth- and nineteenth-century French medical tradition and formulated ideas that are very much part of medicine today. [emphasis mine] Taking a purely analytical and quantitative approach, physicians like François Broussais (1772-1838) believed disease resulted from a surplus or lack of some organic substance, such as blood. Bloodletting was regularly used as a form of treatment. France imported 33 million leeches from southern Europe in the first half of the nineteenth century. Canguilhem saw the organism as a totality that interacted with its environment [emphasis mine] rather than a mere aggregation of parts whose functioning depended only on a ‘normal’ amount of the right organic substances,” Safra said.

In Canguilhem, the movement changes. Instead of transiting from the part to the whole, he moves from the whole to the part (as does Kant in the Critique of Judgment). He views the organism not as a machine but as an integral self-regulating totality. Life cannot be deduced from physical and chemical laws. One must start from the living being to understand life. Practice is the bridge that connects this totality to the environment. At the same time as it changes the environment, practice changes the organism and helps determine its physiological states.

“So Canguilhem implies that in order to find a state called normal, i.e. healthy, a given organism has to adapt its own operating rules to the outside world in the course of interacting concretely and practically with the environment. A human organism, for example, is in a ‘normal’ state when its pulse slows sharply after a period of long daily running. A case in point is the long-distance runner, who has to train every day,” Safra said.

“For Canguilhem, disease is due to inadaptation between the part, the organism and the environment, and often manifests itself as a feeling of malaise. Adaptive mechanisms in the organism can correct pathological dysfunctions.”

The article resulted from Sfara’s postdoctoral research supervised by Márcio Suzuki and supported by FAPESP.

The article “From technique to normativity: the influence of Kant on Georges Canguilhem’s philosophy of life” is at: link.springer.com/article/10.1007/s40656-023-00573-8.

This text was originally published by FAPESP Agency according to Creative Commons license CC-BY-NC-ND. Read the original here.https://agencia.fapesp.br/republicacao_frame?url=https://agencia.fapesp.br/study-shows-kants-influence-on-georges-canguilhem-who-anticipated-concepts-current-in-medicine-today/41794/&utm_source=republish&utm_medium=republish&utm_content=https://agencia.fapesp.br/study-shows-kants-influence-on-georges-canguilhem-who-anticipated-concepts-current-in-medicine-today/41794/

Even though you can find a link to the paper in the press release, here’s my version of a citation complete with link,

From technique to normativity: the influence of Kant on Georges Canguilhem’s philosophy of life by Emiliano Sfara .History and Philosophy of the Life Sciences volume 45, Article number: 16 (2023) DOI: https://doi.org/10.1007/s40656-023-00573-8 Published: 06 April 2023

This paper is open access.