Canada’s national newspaper (as they like to bill themselves), the Globe and Mail featured Québec researcher’s (Sylvain Martel) work in a Dec. 13, 2011 article by Bertrand Marotte. From the news article,
Professor Sylvain Martel is already a world leader in the field of nano-robotics, but now he’s working to make a medical dream reality: To deliver toxic drug treatments directly to cancerous cells without damaging the body’s healthy tissue.
It seems that his next project will combine the work on bacteria and microcarriers (from the Globe and Mail article),
Bolstered by his recent success in guiding micro-carriers loaded with cancer-fighting medications into a rabbit’s liver, he and his team of up to 20 researchers from several disciplines are working to transfer the method to the treatment of colorectal cancer in humans within four years.
This time around he is not using micro-carriers to deliver the drug to the tumour, but rather bacteria.
Here’s a video of the bacteria which illustrates Martel’s earlier success with ‘training’ them to build a pyramid.
The latest breakthrough reported in March 2011 (from my posting) implemented an MRI (magnetic resonance imaging) machine,
Known for being the world’s first researcher to have guided a magnetic sphere through a living artery, Professor Martel is announcing a spectacular new breakthrough in the field of nanomedicine. Using a magnetic resonance imaging (MRI) system, his team successfully guided microcarriers loaded with a dose of anti-cancer drug through the bloodstream of a living rabbit, right up to a targeted area in the liver, where the drug was successfully administered. This is a medical first that will help improve chemoembolization, a current treatment for liver cancer.
Here’s what Martel is trying to accomplish now (from the Globe and Mail article),
The MRI machine’s magnetic field is manipulated by [a] sophisticated software program that helps guide the magnetically sensitive bacteria to the tumour mass.
Attached to the bacteria is a capsule containing the cancer-fighting drug. The bacteria are tricked into swimming to an artificially created “magnetic north” at the centre of the tumour, where they will die off after 30 to 40 minutes. The micro-mules, however, have left their precious cargo: the capsule, whose envelope breaks and releases the drug.
I’m not entirely sure why the drug won’t destroy health tissue after it’s finished with the tumour but that detail is not offered in Marotte’s story which, in the last few paragraphs, switches focus from medical breakthroughs to the importance of venture capital funding for Canadian biotech research.
I wish Martel and his team great success.