Tag Archives: Nokia morph

Training drugs

This summarizes some of what’s happening in nanomedicine and provides a plug (boost) for the  University of Cambridge’s nanotechnology programmes (from a June 26, 2017 news item on Nanowerk),

Nanotechnology is creating new opportunities for fighting disease – from delivering drugs in smart packaging to nanobots powered by the world’s tiniest engines.

Chemotherapy benefits a great many patients but the side effects can be brutal.
When a patient is injected with an anti-cancer drug, the idea is that the molecules will seek out and destroy rogue tumour cells. However, relatively large amounts need to be administered to reach the target in high enough concentrations to be effective. As a result of this high drug concentration, healthy cells may be killed as well as cancer cells, leaving many patients weak, nauseated and vulnerable to infection.

One way that researchers are attempting to improve the safety and efficacy of drugs is to use a relatively new area of research known as nanothrapeutics to target drug delivery just to the cells that need it.

Professor Sir Mark Welland is Head of the Electrical Engineering Division at Cambridge. In recent years, his research has focused on nanotherapeutics, working in collaboration with clinicians and industry to develop better, safer drugs. He and his colleagues don’t design new drugs; instead, they design and build smart packaging for existing drugs.

The University of Cambridge has produced a video interview (referencing a 1966 movie ‘Fantastic Voyage‘ in its title)  with Sir Mark Welland,

A June 23, 2017 University of Cambridge press release, which originated the news item, delves further into the topic of nanotherapeutics (nanomedicine) and nanomachines,

Nanotherapeutics come in many different configurations, but the easiest way to think about them is as small, benign particles filled with a drug. They can be injected in the same way as a normal drug, and are carried through the bloodstream to the target organ, tissue or cell. At this point, a change in the local environment, such as pH, or the use of light or ultrasound, causes the nanoparticles to release their cargo.

Nano-sized tools are increasingly being looked at for diagnosis, drug delivery and therapy. “There are a huge number of possibilities right now, and probably more to come, which is why there’s been so much interest,” says Welland. Using clever chemistry and engineering at the nanoscale, drugs can be ‘taught’ to behave like a Trojan horse, or to hold their fire until just the right moment, or to recognise the target they’re looking for.

“We always try to use techniques that can be scaled up – we avoid using expensive chemistries or expensive equipment, and we’ve been reasonably successful in that,” he adds. “By keeping costs down and using scalable techniques, we’ve got a far better chance of making a successful treatment for patients.”

In 2014, he and collaborators demonstrated that gold nanoparticles could be used to ‘smuggle’ chemotherapy drugs into cancer cells in glioblastoma multiforme, the most common and aggressive type of brain cancer in adults, which is notoriously difficult to treat. The team engineered nanostructures containing gold and cisplatin, a conventional chemotherapy drug. A coating on the particles made them attracted to tumour cells from glioblastoma patients, so that the nanostructures bound and were absorbed into the cancer cells.

Once inside, these nanostructures were exposed to radiotherapy. This caused the gold to release electrons that damaged the cancer cell’s DNA and its overall structure, enhancing the impact of the chemotherapy drug. The process was so effective that 20 days later, the cell culture showed no evidence of any revival, suggesting that the tumour cells had been destroyed.

While the technique is still several years away from use in humans, tests have begun in mice. Welland’s group is working with MedImmune, the biologics R&D arm of pharmaceutical company AstraZeneca, to study the stability of drugs and to design ways to deliver them more effectively using nanotechnology.

“One of the great advantages of working with MedImmune is they understand precisely what the requirements are for a drug to be approved. We would shut down lines of research where we thought it was never going to get to the point of approval by the regulators,” says Welland. “It’s important to be pragmatic about it so that only the approaches with the best chance of working in patients are taken forward.”

The researchers are also targeting diseases like tuberculosis (TB). With funding from the Rosetrees Trust, Welland and postdoctoral researcher Dr Íris da luz Batalha are working with Professor Andres Floto in the Department of Medicine to improve the efficacy of TB drugs.

Their solution has been to design and develop nontoxic, biodegradable polymers that can be ‘fused’ with TB drug molecules. As polymer molecules have a long, chain-like shape, drugs can be attached along the length of the polymer backbone, meaning that very large amounts of the drug can be loaded onto each polymer molecule. The polymers are stable in the bloodstream and release the drugs they carry when they reach the target cell. Inside the cell, the pH drops, which causes the polymer to release the drug.

In fact, the polymers worked so well for TB drugs that another of Welland’s postdoctoral researchers, Dr Myriam Ouberaï, has formed a start-up company, Spirea, which is raising funding to develop the polymers for use with oncology drugs. Ouberaï is hoping to establish a collaboration with a pharma company in the next two years.

“Designing these particles, loading them with drugs and making them clever so that they release their cargo in a controlled and precise way: it’s quite a technical challenge,” adds Welland. “The main reason I’m interested in the challenge is I want to see something working in the clinic – I want to see something working in patients.”

Could nanotechnology move beyond therapeutics to a time when nanomachines keep us healthy by patrolling, monitoring and repairing the body?

Nanomachines have long been a dream of scientists and public alike. But working out how to make them move has meant they’ve remained in the realm of science fiction.

But last year, Professor Jeremy Baumberg and colleagues in Cambridge and the University of Bath developed the world’s tiniest engine – just a few billionths of a metre [nanometre] in size. It’s biocompatible, cost-effective to manufacture, fast to respond and energy efficient.

The forces exerted by these ‘ANTs’ (for ‘actuating nano-transducers’) are nearly a hundred times larger than those for any known device, motor or muscle. To make them, tiny charged particles of gold, bound together with a temperature-responsive polymer gel, are heated with a laser. As the polymer coatings expel water from the gel and collapse, a large amount of elastic energy is stored in a fraction of a second. On cooling, the particles spring apart and release energy.

The researchers hope to use this ability of ANTs to produce very large forces relative to their weight to develop three-dimensional machines that swim, have pumps that take on fluid to sense the environment and are small enough to move around our bloodstream.

Working with Cambridge Enterprise, the University’s commercialisation arm, the team in Cambridge’s Nanophotonics Centre hopes to commercialise the technology for microfluidics bio-applications. The work is funded by the Engineering and Physical Sciences Research Council and the European Research Council.

“There’s a revolution happening in personalised healthcare, and for that we need sensors not just on the outside but on the inside,” explains Baumberg, who leads an interdisciplinary Strategic Research Network and Doctoral Training Centre focused on nanoscience and nanotechnology.

“Nanoscience is driving this. We are now building technology that allows us to even imagine these futures.”

I have featured Welland and his work here before and noted his penchant for wanting to insert nanodevices into humans as per this excerpt from an April 30, 2010 posting,
Getting back to the Cambridge University video, do go and watch it on the Nanowerk site. It is fun and very informative and approximately 17 mins. I noticed that they reused part of their Nokia morph animation (last mentioned on this blog here) and offered some thoughts from Professor Mark Welland, the team leader on that project. Interestingly, Welland was talking about yet another possibility. (Sometimes I think nano goes too far!) He was suggesting that we could have chips/devices in our brains that would allow us to think about phoning someone and an immediate connection would be made to that person. Bluntly—no. Just think what would happen if the marketers got access and I don’t even want to think what a person who suffers psychotic breaks (i.e., hearing voices) would do with even more input. Welland starts to talk at the 11 minute mark (I think). For an alternative take on the video and more details, visit Dexter Johnson’s blog, Nanoclast, for this posting. Hint, he likes the idea of a phone in the brain much better than I do.

I’m not sure what could have occasioned this latest press release and related video featuring Welland and nanotherapeutics other than guessing that it was a slow news period.

Human-Computer interfaces: flying with thoughtpower, reading minds, and wrapping a telephone around your wrist

This time I’ve decided to explore a few of the human/computer interface stories I’ve run across lately. So this posting is largely speculative and rambling as I’m not driving towards a conclusion.

My first item is a May 3, 2011 news item on physorg.com. It concerns an art installation at Rensselaer Polytechnic Institute, The Ascent. From the news item,

A team of Rensselaer Polytechnic Institute students has created a system that pairs an EEG headset with a 3-D theatrical flying harness, allowing users to “fly” by controlling their thoughts. The “Infinity Simulator” will make its debut with an art installation [The Ascent] in which participants rise into the air – and trigger light, sound, and video effects – by calming their thoughts.

I found a video of someone demonstrating this project:
http://blog.makezine.com/archive/2011/03/eeg-controlled-wire-flight.html

Please do watch:

I’ve seen this a few times and it still absolutely blows me away.

If you should be near Rensselaer on May 12, 2011, you could have a chance to fly using your own thoughtpower, a harness, and an EEG helmet. From the event webpage,

Come ride The Ascent, a playful mash-up of theatrics, gaming and mind-control. The Ascent is a live-action, theatrical ride experience created for almost anyone to try. Individual riders wear an EEG headset, which reads brainwaves, along with a waist harness, and by marshaling their calm, focus, and concentration, try to levitate themselves thirty feet into the air as a small audience watches from below. The experience is full of obstacles-as a rider ascends via the power of concentration, sound and light also respond to brain activity, creating a storm of stimuli that conspires to distract the rider from achieving the goal: levitating into “transcendence.” The paradox is that in order to succeed, you need to release your desire for achievement, and contend with what might be the biggest obstacle: yourself.

Theater Artist and Experience Designer Yehuda Duenyas (XXXY) presents his MFA Thesis project The Ascent, and its operating platform the Infinity System, a new user driven experience created specifically for EMPAC’s automated rigging system.

The Infinity System is a new platform and user interface for 3D flying which combines aspects of thrill-ride, live-action video game, and interactive installation.

Using a unique and intuitive interface, the Infinity System uses 3D rigging to move bodies creatively through space, while employing wearable sensors to manipulate audio and visual content.

Like a live-action stunt-show crossed with a video game, the user is given the superhuman ability to safely and freely fly, leap, bound, flip, run up walls, fall from great heights, swoop, buzz, drop, soar, and otherwise creatively defy gravity.

“The effect is nothing short of movie magic.” – Sean Hollister, Engadget

Here’s a brief description of the technology behind this ‘Ascent’ (from the news item on physorg.com),

Ten computer programs running simultaneously link the commercially available EEG headset to the computer-controlled 3-D flying harness and various theater systems, said Todd. [Michael Todd, a Rensselaer 2010 graduate in computer science]

Within the theater, the rigging – including the harness – is controlled by a Stage Tech NOMAD console; lights are controlled by an ION console running MIDI show control; sound through MAX/MSP; and video through Isadora and Jitter. The “Infinity Simulator,” a series of three C programs written by Todd, acts as intermediary between the headset and the theater systems, connecting and conveying all input and output.

“We’ve built a software system on top of the rigging control board and now have control of it through an iPad, and since we have the iPad control, we can have anything control it,” said Duenyas. “The ‘Infinity Simulator’ is the center; everything talks to the ‘Infinity Simulator.’”

This May 3, 2011 article (Mystery Man Gives Mind-Reading Tech More Early Cash Than Facebook, Google Combined) by Kit Eaton on Fast Company also concerns itself with a brain/computer interface. From the article,

Imagine the money that could be made by a drug company that accurately predicted and treated the onset of Alzheimer’s before any symptoms surfaced. That may give us an idea why NeuroVigil, a company specializing in non-invasive, wireless brain-recording tech, just got a cash injection that puts it at a valuation “twice the combined seed valuations of Google’s and Facebook’s first rounds,” according to a company announcement

NeuroVigil’s key product at the moment is the iBrain, a slim device in a flexible head-cap that’s designed to be worn for continuous EEG monitoring of a patient’s brain function–mainly during sleep. It’s non-invasive, and replaces older technology that could only access these kind of brain functions via critically implanted electrodes actually on the brain itself. The idea is, first, to record how brain function changes over time, perhaps as a particular combination of drugs is administered or to help diagnose particular brain pathologies–such as epilepsy.

But the other half of the potentailly lucrative equation is the ability to analyze the trove of data coming from iBrain. And that’s where NeuroVigil’s SPEARS algorithm enters the picture. Not only is the company simplifying collection of brain data with a device that can be relatively comfortably worn during all sorts of tasks–sleeping, driving, watching advertising–but the combination of iBrain and SPEARS multiplies the efficiency of data analysis [emphasis mine].

I assume it’s the notion of combining the two technologies (iBrian and SPEARS) that spawned the ‘mind-reading’ part of this article’s title. The technology could be used for early detection and diagnosis, as well as, other possibilities as Eaton notes,

It’s also possible it could develop its technology into non-medicinal uses such as human-computer interfaces–in an earlier announcement, NeuroVigil noted, “We plan to make these kinds of devices available to the transportation industry, biofeedback, and defense. Applications regarding pandemics and bioterrorism are being considered but cannot be shared in this format.” And there’s even a popular line of kid’s toys that use an essentially similar technique, powered by NeuroSky sensors–themselves destined for future uses as games console controllers or even input devices for computers.

What these two technologies have in common is that, in some fashion or other, they have (shy of implanting a computer chip) a relatively direct interface with our brains, which means (to me anyway) a very different relationship between humans and computers.

In the next couple of items I’m going to profile a couple of very similar to each other technologies that allow for more traditional human/computer interactions, one of which I’ve posted about previously, the Nokia Morph (most recently in my Sept. 29, 2010 posting).

It was first introduced as a type of flexible phone with other capabilities. Since then, they seem to have elaborated on those capabilities. Here’s a description of what they now call the ‘Morph concept’ in a [ETA May 12, 2011: inserted correct link information] May 4, 2011 news item on Nanowerk,

Morph is a joint nanotechnology concept developed by Nokia Research Center (NRC) and the University of Cambridge (UK). Morph is a concept that demonstrates how future mobile devices might be stretchable and flexible, allowing the user to transform their mobile device into radically different shapes. It demonstrates the ultimate functionality that nanotechnology might be capable of delivering: flexible materials, transparent electronics and self-cleaning surfaces.

Morph, will act as a gateway. It will connect the user to the local environment as well as the global internet. It is an attentive device that adapts to the context – it shapes according to the context. The device can change its form from rigid to flexible and stretchable. Buttons of the user interface can grow up from a flat surface when needed. User will never have to worry about the battery life. It is a device that will help us in our everyday life, to keep our self connected and in shape. It is one significant piece of a system that will help us to look after the environment.

Without the new materials, i.e. new structures enabled by the novel materials and manufacturing methods it would be impossible to build Morph kind of device. Graphene has an important role in different components of the new device and the ecosystem needed to make the gateway and context awareness possible in an energy efficient way.

Graphene will enable evolution of the current technology e.g. continuation of the ever increasing computing power when the performance of the computing would require sub nanometer scale transistors by using conventional materials.

For someone who’s been following news of the Morph for the last few years, this news item doesn’t give you any new information. Still, it’s nice to be reminded of the Morph project. Here’s a video produced by the University of Cambridge that illustrates some of the project’s hopes for the Morph concept,

While the folks at the Nokia Research Centre and University of Cambridge have been working on their project, it appears the team at the Human Media Lab at the School of Computing at Queen’s University (Kingston, Ontario, Canada) in cooperation with a team from Arizona State University and E Ink Corporation have been able to produce a prototype of something remarkably similar, albeit with fewer functions. The PaperPhone is being introduced at the Association of Computing Machinery’s CHI 2011 (Computer Human Interaction) conference in Vancouver, Canada next Tuesday, May 10, 2011.

Here’s more about it from a May 4, 2011 news item on Nanowerk,

The world’s first interactive paper computer is set to revolutionize the world of interactive computing.

“This is the future. Everything is going to look and feel like this within five years,” says creator Roel Vertegaal, the director of Queen’s University Human Media Lab,. “This computer looks, feels and operates like a small sheet of interactive paper. You interact with it by bending it into a cell phone, flipping the corner to turn pages, or writing on it with a pen.”

The smartphone prototype, called PaperPhone is best described as a flexible iPhone – it does everything a smartphone does, like store books, play music or make phone calls. But its display consists of a 9.5 cm diagonal thin film flexible E Ink display. The flexible form of the display makes it much more portable that any current mobile computer: it will shape with your pocket.

For anyone who knows the novel, it’s very Diamond Age (by Neal Stephenson). On a more technical note, I would have liked more information about the display’s technology. What is E Ink using? Graphene? Carbon nanotubes?

(That does not look like to paper to me but I suppose you could call it ‘paperlike’.)

In reviewing all these news items, it seems to me there are two themes, the computer as bodywear and the computer as an extension of our thoughts. Both of these are more intimate relationships, the latter far more so than the former, than we’ve had with the computer till now. If any of you have any thoughts on this, please do leave a comment as I would be delighted to engage on some discussion about this.

You can get more information about the Association of Computing Machinery’s CHI 2011 (Computer Human Interaction) conference where Dr. Vertegaal will be presenting here.

You can find more about Dr. Vertegaal and the Human Media Lab at Queen’s University here.

The academic paper being presented at the Vancouver conference is here.

Also, if you are interested in the hardware end of things, you can check out E Ink Corporation, the company that partnered with the team from Queen’s and Arizona State University to create the PaperPhone. Interestingly, E Ink is a spin off company from the Massachusetts Institute of Technology (MIT).

The Morph morphs?

There was a lot of noise a couple years ago about Nokia’s Morph (mentioned briefly in my Feb. 17, 2009 posting and my March 30, 2010 posting) a mobile phone which could wrap around your wrist. As far as I know, an animation is all that exists of the Morph. However, I have come across an article about the Morph and the research centre in Cambridge where much of the work is being done. From the article on the  Nokia Conversation blog,

Getting into a Nokia Research Center laboratory isn’t easy. The security doors remain open long enough for one or two people to enter and if held open too long, will sound what we’re told is an exceptionally loud alarm. Lucky then that we were part of a group taken around NRC’s Cambridge laboratory to see some of the latest scientific problems being solved there. We were treated to demoes of three different strands of research; Nanowire Sensing, Stretchable Electronic Skin and Electrotactile Experience. [emphasis mine]

I gather that any or all three of these research areas could be applicable in some fashion to the Morph, should there be prototype.

Nanowire sensing could allow your phone to sniff (be an artificial nose). Here’s a video about nanowire sensing,

Here’s a video on stretchable electronic skin,

For the elecrotactile experience, I did not find a video so I’m back to the article,

The third of our demoes [sic] was also the most realistic, as it was being shown off on a Nokia N900. The team is working on ways to enable touchscreens to offer more realistic feedback. This goes way beyond simple haptics to deliver genuine tactile response. The team are influenced by the belief that the sensation of touch isn’t currently well understood so they’re trying to work out ways to make it more effective when interacting with technology.

You can see after viewing this Morph animation, how stretchable electronic skin will be applied and how useful research into electrotactile experiences will be for this product,

As for a mobile telephone with an artificial nose, I wouldn’t think that’s especially useful but, in the beginning,  I didn’t think camera and videotaping capabilities would be useful either and I was wrong.

Stephen Fry, Cambridge University, and nanotechnology

Courtesy of Nanowerk, I found a new introductory video, Introduction to the strange new world of nanoscience, that Stephen Fry (actor) narrates on behalf of Cambridge University. Providing a very engaging and delightful introduction to nanotechnology, it also illustrates something I was discussing in one of my postings yesterday. The notion that the adoption of any science or technology is inevitable and not to be questioned is in full display. Since the video’s purpose is to introduce (“sell’) nanotechnology I have no quibble with the video itself, my doubts centre on the fact that the nanotechnology discussion is couched in terms of pro or con with no questioning of the basic premise, i.e., should we do this just because we can and how do we decide one way or the other?

Tim Harper on his TNT blog, which is located on his Cientifica website, offers a possible answer in one of his recent postings,

That’s all there is to technology diffusion, whether GM, nanotech or anything else. It is the ultimate form of democracy, because it is us, the people, who eventually get to choose whether a technology is used or not, not politicians, companies or single issue campaign groups.

Leaving aside the concept of marketplace democracy to shift gears, Harper is making the assumption that nothing catastrophic will occur because according to Harper’s posting on the topic,

After ten years of nanotech scare stories I feel that we have a fairly balanced resreach [sic] agenda, with plenty of good science being backed up by excellent toxicology and risk management studies.

It should be noted that Harper is responding from the perspective of someone located in the UK where there has been far more public discussion and interest in the possible risks associated with nanotechnology than there has been in either Canada or the US.

I have to agree with Harper in some degree with his thesis that the marketplace is where a new technology or innovation fails or succeeds and is where democracy  prevails since in the marketplace, the sloganeering and mud-slinging from all sides becomes irrelevant as technology is adopted or it isn’t.

However, it might be time to consider some alternatives to marketplace democracy because, unlike Harper, I’m not quite so confident about the toxicology and risk management studies undertaken so far and the stakes are much higher than they have been in the past. I realize that it’ s impossible to have 100% confidence and I find many of nanotechnology’s possible benefits quite compelling so I’m willing go along with it to a point. I just don’t want to lose sight of the fact that we are juggling many possibilities in a very dynamic environment and using methods and models that worked in times past is rather like showing up to a modern battle zone dressed in medieval armour.

Getting back to the Cambridge University video, do go and watch it on the Nanowerk site. It is fun and very informative and approximately 17 mins. I noticed that they reused part of their Nokia morph animation (last mentioned on this blog here) and offered some thoughts from Professor Mark Welland, the team leader on that project. Interestingly, Welland was talking about yet another possibility. (Sometimes I think nano goes too far!) He was suggesting that we could have chips/devices in our brains that would allow us to think about phoning someone and an immediate connection would be made to that person. Bluntly—no. Just think what would happen if the marketers got access and I don’t even want to think what a person who suffers psychotic breaks (i.e., hearing voices) would do with even more input. Welland starts to talk at the 11 minute mark (I think). For an alternative take on the video and more details, visit Dexter Johnson’s blog, Nanoclast, for this posting. Hint, he likes the idea of a phone in the brain much better than I do.

You can also find the video here on the Cambridge University site where you’ll also find out it was funded by the European Commission for a nanotechnology dialogue project called NanoYou.