Tag Archives: Royal Swedish Academy of Sciences

2023 Nobel prizes (medicine, physics, and chemistry)

For the first time in the 15 years this blog has been around, the Nobel prizes awarded in medicine, physics, and chemistry all are in areas discussed here at one or another. As usual where people are concerned, some of these scientists had a tortuous journey to this prestigious outcome.

Medicine

Two people (Katalin Karikó and Drew Weissman) were awarded the prize in medicine according to the October 2, 2023 Nobel Prize press release, Note: Links have been removed,

The Nobel Assembly at Karolinska Institutet [Sweden]

has today decided to award

the 2023 Nobel Prize in Physiology or Medicine

jointly to

Katalin Karikó and Drew Weissman

for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19

The discoveries by the two Nobel Laureates were critical for developing effective mRNA vaccines against COVID-19 during the pandemic that began in early 2020. Through their groundbreaking findings, which have fundamentally changed our understanding of how mRNA interacts with our immune system, the laureates contributed to the unprecedented rate of vaccine development during one of the greatest threats to human health in modern times.

Vaccines before the pandemic

Vaccination stimulates the formation of an immune response to a particular pathogen. This gives the body a head start in the fight against disease in the event of a later exposure. Vaccines based on killed or weakened viruses have long been available, exemplified by the vaccines against polio, measles, and yellow fever. In 1951, Max Theiler was awarded the Nobel Prize in Physiology or Medicine for developing the yellow fever vaccine.

Thanks to the progress in molecular biology in recent decades, vaccines based on individual viral components, rather than whole viruses, have been developed. Parts of the viral genetic code, usually encoding proteins found on the virus surface, are used to make proteins that stimulate the formation of virus-blocking antibodies. Examples are the vaccines against the hepatitis B virus and human papillomavirus. Alternatively, parts of the viral genetic code can be moved to a harmless carrier virus, a “vector.” This method is used in vaccines against the Ebola virus. When vector vaccines are injected, the selected viral protein is produced in our cells, stimulating an immune response against the targeted virus.

Producing whole virus-, protein- and vector-based vaccines requires large-scale cell culture. This resource-intensive process limits the possibilities for rapid vaccine production in response to outbreaks and pandemics. Therefore, researchers have long attempted to develop vaccine technologies independent of cell culture, but this proved challenging.

Illustration of methods for vaccine production before the COVID-19 pandemic.
Figure 1. Methods for vaccine production before the COVID-19 pandemic. © The Nobel Committee for Physiology or Medicine. Ill. Mattias Karlén

mRNA vaccines: A promising idea

In our cells, genetic information encoded in DNA is transferred to messenger RNA (mRNA), which is used as a template for protein production. During the 1980s, efficient methods for producing mRNA without cell culture were introduced, called in vitro transcription. This decisive step accelerated the development of molecular biology applications in several fields. Ideas of using mRNA technologies for vaccine and therapeutic purposes also took off, but roadblocks lay ahead. In vitro transcribed mRNA was considered unstable and challenging to deliver, requiring the development of sophisticated carrier lipid systems to encapsulate the mRNA. Moreover, in vitro-produced mRNA gave rise to inflammatory reactions. Enthusiasm for developing the mRNA technology for clinical purposes was, therefore, initially limited.

These obstacles did not discourage the Hungarian biochemist Katalin Karikó, who was devoted to developing methods to use mRNA for therapy. During the early 1990s, when she was an assistant professor at the University of Pennsylvania, she remained true to her vision of realizing mRNA as a therapeutic despite encountering difficulties in convincing research funders of the significance of her project. A new colleague of Karikó at her university was the immunologist Drew Weissman. He was interested in dendritic cells, which have important functions in immune surveillance and the activation of vaccine-induced immune responses. Spurred by new ideas, a fruitful collaboration between the two soon began, focusing on how different RNA types interact with the immune system.

The breakthrough

Karikó and Weissman noticed that dendritic cells recognize in vitro transcribed mRNA as a foreign substance, which leads to their activation and the release of inflammatory signaling molecules. They wondered why the in vitro transcribed mRNA was recognized as foreign while mRNA from mammalian cells did not give rise to the same reaction. Karikó and Weissman realized that some critical properties must distinguish the different types of mRNA.

RNA contains four bases, abbreviated A, U, G, and C, corresponding to A, T, G, and C in DNA, the letters of the genetic code. Karikó and Weissman knew that bases in RNA from mammalian cells are frequently chemically modified, while in vitro transcribed mRNA is not. They wondered if the absence of altered bases in the in vitro transcribed RNA could explain the unwanted inflammatory reaction. To investigate this, they produced different variants of mRNA, each with unique chemical alterations in their bases, which they delivered to dendritic cells. The results were striking: The inflammatory response was almost abolished when base modifications were included in the mRNA. This was a paradigm change in our understanding of how cells recognize and respond to different forms of mRNA. Karikó and Weissman immediately understood that their discovery had profound significance for using mRNA as therapy. These seminal results were published in 2005, fifteen years before the COVID-19 pandemic.

Illustration of the four different bases mRNA contains.
Figure 2. mRNA contains four different bases, abbreviated A, U, G, and C. The Nobel Laureates discovered that base-modified mRNA can be used to block activation of inflammatory reactions (secretion of signaling molecules) and increase protein production when mRNA is delivered to cells.  © The Nobel Committee for Physiology or Medicine. Ill. Mattias Karlén

In further studies published in 2008 and 2010, Karikó and Weissman showed that the delivery of mRNA generated with base modifications markedly increased protein production compared to unmodified mRNA. The effect was due to the reduced activation of an enzyme that regulates protein production. Through their discoveries that base modifications both reduced inflammatory responses and increased protein production, Karikó and Weissman had eliminated critical obstacles on the way to clinical applications of mRNA.

mRNA vaccines realized their potential

Interest in mRNA technology began to pick up, and in 2010, several companies were working on developing the method. Vaccines against Zika virus and MERS-CoV were pursued; the latter is closely related to SARS-CoV-2. After the outbreak of the COVID-19 pandemic, two base-modified mRNA vaccines encoding the SARS-CoV-2 surface protein were developed at record speed. Protective effects of around 95% were reported, and both vaccines were approved as early as December 2020.

The impressive flexibility and speed with which mRNA vaccines can be developed pave the way for using the new platform also for vaccines against other infectious diseases. In the future, the technology may also be used to deliver therapeutic proteins and treat some cancer types.

Several other vaccines against SARS-CoV-2, based on different methodologies, were also rapidly introduced, and together, more than 13 billion COVID-19 vaccine doses have been given globally. The vaccines have saved millions of lives and prevented severe disease in many more, allowing societies to open and return to normal conditions. Through their fundamental discoveries of the importance of base modifications in mRNA, this year’s Nobel laureates critically contributed to this transformative development during one of the biggest health crises of our time.

Read more about this year’s prize

Scientific background: Discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19

Katalin Karikó was born in 1955 in Szolnok, Hungary. She received her PhD from Szeged’s University in 1982 and performed postdoctoral research at the Hungarian Academy of Sciences in Szeged until 1985. She then conducted postdoctoral research at Temple University, Philadelphia, and the University of Health Science, Bethesda. In 1989, she was appointed Assistant Professor at the University of Pennsylvania, where she remained until 2013. After that, she became vice president and later senior vice president at BioNTech RNA Pharmaceuticals. Since 2021, she has been a Professor at Szeged University and an Adjunct Professor at Perelman School of Medicine at the University of Pennsylvania.

Drew Weissman was born in 1959 in Lexington, Massachusetts, USA. He received his MD, PhD degrees from Boston University in 1987. He did his clinical training at Beth Israel Deaconess Medical Center at Harvard Medical School and postdoctoral research at the National Institutes of Health. In 1997, Weissman established his research group at the Perelman School of Medicine at the University of Pennsylvania. He is the Roberts Family Professor in Vaccine Research and Director of the Penn Institute for RNA Innovations.

The University of Pennsylvania October 2, 2023 news release is a very interesting announcement (more about why it’s interesting afterwards), Note: Links have been removed,

The University of Pennsylvania messenger RNA pioneers whose years of scientific partnership unlocked understanding of how to modify mRNA to make it an effective therapeutic—enabling a platform used to rapidly develop lifesaving vaccines amid the global COVID-19 pandemic—have been named winners of the 2023 Nobel Prize in Physiology or Medicine. They become the 28th and 29th Nobel laureates affiliated with Penn, and join nine previous Nobel laureates with ties to the University of Pennsylvania who have won the Nobel Prize in Medicine.

Nearly three years after the rollout of mRNA vaccines across the world, Katalin Karikó, PhD, an adjunct professor of Neurosurgery in Penn’s Perelman School of Medicine, and Drew Weissman, MD, PhD, the Roberts Family Professor of Vaccine Research in the Perelman School of Medicine, are recipients of the prize announced this morning by the Nobel Assembly in Solna, Sweden.

After a chance meeting in the late 1990s while photocopying research papers, Karikó and Weissman began investigating mRNA as a potential therapeutic. In 2005, they published a key discovery: mRNA could be altered and delivered effectively into the body to activate the body’s protective immune system. The mRNA-based vaccines elicited a robust immune response, including high levels of antibodies that attack a specific infectious disease that has not previously been encountered. Unlike other vaccines, a live or attenuated virus is not injected or required at any point.

When the COVID-19 pandemic struck, the true value of the pair’s lab work was revealed in the most timely of ways, as companies worked to quickly develop and deploy vaccines to protect people from the virus. Both Pfizer/BioNTech and Moderna utilized Karikó and Weissman’s technology to build their highly effective vaccines to protect against severe illness and death from the virus. In the United States alone, mRNA vaccines make up more than 655 million total doses of SARS-CoV-2 vaccines that have been administered since they became available in December 2020.

Editor’s Note: The Pfizer/BioNTech and Moderna COVID-19 mRNA vaccines both use licensed University of Pennsylvania technology. As a result of these licensing relationships, Penn, Karikó and Weissman have received and may continue to receive significant financial benefits in the future based on the sale of these products. BioNTech provides funding for Weissman’s research into the development of additional infectious disease vaccines.

Science can be brutal

Now for the interesting bit: it’s in my March 5, 2021 posting (mRNA, COVID-19 vaccines, treating genetic diseases before birth, and the scientist who started it all),

Before messenger RNA was a multibillion-dollar idea, it was a scientific backwater. And for the Hungarian-born scientist behind a key mRNA discovery, it was a career dead-end.

Katalin Karikó spent the 1990s collecting rejections. Her work, attempting to harness the power of mRNA to fight disease, was too far-fetched for government grants, corporate funding, and even support from her own colleagues.

“Every night I was working: grant, grant, grant,” Karikó remembered, referring to her efforts to obtain funding. “And it came back always no, no, no.”

By 1995, after six years on the faculty at the University of Pennsylvania, Karikó got demoted. [emphasis mine] She had been on the path to full professorship, but with no money coming in to support her work on mRNA, her bosses saw no point in pressing on.

She was back to the lower rungs of the scientific academy.

“Usually, at that point, people just say goodbye and leave because it’s so horrible,” Karikó said.

There’s no opportune time for demotion, but 1995 had already been uncommonly difficult. Karikó had recently endured a cancer scare, and her husband was stuck in Hungary sorting out a visa issue. Now the work to which she’d devoted countless hours was slipping through her fingers.

In time, those better experiments came together. After a decade of trial and error, Karikó and her longtime collaborator at Penn — Drew Weissman [emphasis mine], an immunologist with a medical degree and Ph.D. from Boston University — discovered a remedy for mRNA’s Achilles’ heel.

You can get the whole story from my March 5, 2021 posting, scroll down to the “mRNA—it’s in the details, plus, the loneliness of pioneer researchers, a demotion, and squabbles” subhead. If you are very curious about mRNA and the rough and tumble of the world of science, there’s my August 20, 2021 posting “Getting erased from the mRNA/COVID-19 story” where Ian MacLachlan is featured as a researcher who got erased and where Karikó credits his work.

‘Rowing Mom Wins Nobel’ (credit: rowing website Row 2K)

Karikó’s daughter is a two-time gold medal Olympic athlete as the Canadian Broadcasting Corporation’s (CBC) radio programme, As It Happens, notes in an interview with the daughter (Susan Francia). From an October 4, 2023 As It Happens article (with embedded audio programme excerpt) by Sheena Goodyear,

Olympic gold medallist Susan Francia is coming to terms with the fact that she’s no longer the most famous person in her family.

That’s because the retired U.S. rower’s mother, Katalin Karikó, just won a Nobel Prize in Medicine. The biochemist was awarded alongside her colleague, vaccine researcher Drew Weissman, for their groundbreaking work that led to the development of COVID-19 vaccines. 

“Now I’m like, ‘Shoot! All right, I’ve got to work harder,'” Francia said with a laugh during an interview with As It Happens host Nil Köksal. 

But in all seriousness, Francia says she’s immensely proud of her mother’s accomplishments. In fact, it was Karikó’s fierce dedication to science that inspired Francia to win Olympic gold medals in 2008 and 2012.

“Sport is a lot like science in that, you know, you have a passion for something and you just go and you train, attain your goal, whether it be making this discovery that you truly believe in, or for me, it was trying to be the best in the world,” Francia said.

“It’s a grind and, honestly, I love that grind. And my mother did too.”

… one of her [Karikó] favourite headlines so far comes from a little blurb on the rowing website Row 2K: “Rowing Mom Wins Nobel.”

Nowadays, scientists are trying to harness the power of mRNA to fight cancer, malaria, influenza and rabies. But when Karikó first began her work, it was a fringe concept. For decades, she toiled in relative obscurity, struggling to secure funding for her research.

“That’s also that same passion that I took into my rowing,” Francia said.

But even as Karikó struggled to make a name for herself, she says her own mother, Zsuzsanna, always believed she would earn a Nobel Prize one day.

Every year, as the Nobel Prize announcement approached, she would tell Karikó she’d be watching for her name. 

“I was laughing [and saying] that, ‘Mom, I am not getting anything,'” she said. 

But her mother, who died a few years ago, ultimately proved correct. 

Congratulations to both Katalin Karikó and Drew Weissman and thank you both for persisting!

Physics

This prize is for physics at the attoscale.

Aaron W. Harrison (Assistant Professor of Chemistry, Austin College, Texas, US) attempts an explanation of an attosecond in his October 3, 2023 essay (in English “What is an attosecond? A physical chemist explains the tiny time scale behind Nobel Prize-winning research” and in French “Nobel de physique : qu’est-ce qu’une attoseconde?”) for The Conversation, Note: Links have been removed,

“Atto” is the scientific notation prefix that represents 10-18, which is a decimal point followed by 17 zeroes and a 1. So a flash of light lasting an attosecond, or 0.000000000000000001 of a second, is an extremely short pulse of light.

In fact, there are approximately as many attoseconds in one second as there are seconds in the age of the universe.

Previously, scientists could study the motion of heavier and slower-moving atomic nuclei with femtosecond (10-15) light pulses. One thousand attoseconds are in 1 femtosecond. But researchers couldn’t see movement on the electron scale until they could generate attosecond light pulses – electrons move too fast for scientists to parse exactly what they are up to at the femtosecond level.

Harrison does a very good job of explaining something that requires a leap of imagination. He also explains why scientists engage in attosecond research. h/t October 4, 2023 news item on phys.org

Amelle Zaïr (Imperial College London) offers a more technical explanation in her October 4, 2023 essay about the 2023 prize winners for The Conversation. h/t October 4, 2023 news item on phys.org

Main event

Here’s the October 3, 2023 Nobel Prize press release, Note: A link has been removed,

The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Physics 2023 to

Pierre Agostini
The Ohio State University, Columbus, USA

Ferenc Krausz
Max Planck Institute of Quantum Optics, Garching and Ludwig-Maximilians-Universität München, Germany

Anne L’Huillier
Lund University, Sweden

“for experimental methods that generate attosecond pulses of light for the study of electron dynamics in matter”

Experiments with light capture the shortest of moments

The three Nobel Laureates in Physics 2023 are being recognised for their experiments, which have given humanity new tools for exploring the world of electrons inside atoms and molecules. Pierre Agostini, Ferenc Krausz and Anne L’Huillier have demonstrated a way to create extremely short pulses of light that can be used to measure the rapid processes in which electrons move or change energy.

Fast-moving events flow into each other when perceived by humans, just like a film that consists of still images is perceived as continual movement. If we want to investigate really brief events, we need special technology. In the world of electrons, changes occur in a few tenths of an attosecond – an attosecond is so short that there are as many in one second as there have been seconds since the birth of the universe.

The laureates’ experiments have produced pulses of light so short that they are measured in attoseconds, thus demonstrating that these pulses can be used to provide images of processes inside atoms and molecules.

In 1987, Anne L’Huillier discovered that many different overtones of light arose when she transmitted infrared laser light through a noble gas. Each overtone is a light wave with a given number of cycles for each cycle in the laser light. They are caused by the laser light interacting with atoms in the gas; it gives some electrons extra energy that is then emitted as light. Anne L’Huillier has continued to explore this phenomenon, laying the ground for subsequent breakthroughs.

In 2001, Pierre Agostini succeeded in producing and investigating a series of consecutive light pulses, in which each pulse lasted just 250 attoseconds. At the same time, Ferenc Krausz was working with another type of experiment, one that made it possible to isolate a single light pulse that lasted 650 attoseconds.

The laureates’ contributions have enabled the investigation of processes that are so rapid they were previously impossible to follow.

“We can now open the door to the world of electrons. Attosecond physics gives us the opportunity to understand mechanisms that are governed by electrons. The next step will be utilising them,” says Eva Olsson, Chair of the Nobel Committee for Physics.

There are potential applications in many different areas. In electronics, for example, it is important to understand and control how electrons behave in a material. Attosecond pulses can also be used to identify different molecules, such as in medical diagnostics.

Read more about this year’s prize

Popular science background: Electrons in pulses of light (pdf)
Scientific background: “For experimental methods that generate attosecond pulses of light for the study of electron dynamics in matter” (pdf)

Pierre Agostini. PhD 1968 from Aix-Marseille University, France. Professor at The Ohio State University, Columbus, USA.

Ferenc Krausz, born 1962 in Mór, Hungary. PhD 1991 from Vienna University of Technology, Austria. Director at Max Planck Institute of Quantum Optics, Garching and Professor at Ludwig-Maximilians-Universität München, Germany.

Anne L’Huillier, born 1958 in Paris, France. PhD 1986 from University Pierre and Marie Curie, Paris, France. Professor at Lund University, Sweden.

A Canadian connection?

An October 3, 2023 CBC online news item from the Associated Press reveals a Canadian connection of sorts ,

Three scientists have won the Nobel Prize in physics Tuesday for giving us the first split-second glimpse into the superfast world of spinning electrons, a field that could one day lead to better electronics or disease diagnoses.

The award went to French-Swedish physicist Anne L’Huillier, French scientist Pierre Agostini and Hungarian-born Ferenc Krausz for their work with the tiny part of each atom that races around the centre, and that is fundamental to virtually everything: chemistry, physics, our bodies and our gadgets.

Electrons move around so fast that they have been out of reach of human efforts to isolate them. But by looking at the tiniest fraction of a second possible, scientists now have a “blurry” glimpse of them, and that opens up whole new sciences, experts said.

“The electrons are very fast, and the electrons are really the workforce in everywhere,” Nobel Committee member Mats Larsson said. “Once you can control and understand electrons, you have taken a very big step forward.”

L’Huillier is the fifth woman to receive a Nobel in Physics.

L’Huillier was teaching basic engineering physics to about 100 undergraduates at Lund when she got the call that she had won, but her phone was on silent and she didn’t pick up. She checked it during a break and called the Nobel Committee.

Then she went back to teaching.

Agostini, an emeritus professor at Ohio State University, was in Paris and could not be reached by the Nobel Committee before it announced his win to the world

Here’s the Canadian connection (from the October 3, 2023 CBC online news item),

Krausz, of the Max Planck Institute of Quantum Optics and Ludwig Maximilian University of Munich, told reporters that he was bewildered.

“I have been trying to figure out since 11 a.m. whether I’m in reality or it’s just a long dream,” the 61-year-old said.

Last year, Krausz and L’Huillier won the prestigious Wolf prize in physics for their work, sharing it with University of Ottawa scientist Paul Corkum [emphasis mine]. Nobel prizes are limited to only three winners and Krausz said it was a shame that it could not include Corkum.

Corkum was key to how the split-second laser flashes could be measured [emphasis mine], which was crucial, Krausz said.

Congratulations to Pierre Agostini, Ferenc Krausz and Anne L’Huillier and a bow to Paul Corkum!

For those who are curious. a ‘Paul Corkum’ search should bring up a few postings on this blog but I missed this piece of news, a May 4, 2023 University of Ottawa news release about Corkum and the 2022 Wolf Prize, which he shared with Krausz and L’Huillier,

Chemistry

There was a little drama where this prize was concerned, It was announced too early according to an October 4, 2023 news item on phys.org and, again, in another October 4, 2023 news item on phys.org (from the Oct. 4, 2023 news item by Karl Ritter for the Associated Press),

Oops! Nobel chemistry winners are announced early in a rare slip-up

The most prestigious and secretive prize in science ran headfirst into the digital era Wednesday when Swedish media got an emailed press release revealing the winners of the Nobel Prize in chemistry and the news prematurely went public.

Here’s the fully sanctioned October 4, 2023 Nobel Prize press release, Note: A link has been removed,

The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry 2023 to

Moungi G. Bawendi
Massachusetts Institute of Technology (MIT), Cambridge, MA, USA

Louis E. Brus
Columbia University, New York, NY, USA

Alexei I. Ekimov
Nanocrystals Technology Inc., New York, NY, USA

“for the discovery and synthesis of quantum dots”

They planted an important seed for nanotechnology

The Nobel Prize in Chemistry 2023 rewards the discovery and development of quantum dots, nanoparticles so tiny that their size determines their properties. These smallest components of nanotechnology now spread their light from televisions and LED lamps, and can also guide surgeons when they remove tumour tissue, among many other things.

Everyone who studies chemistry learns that an element’s properties are governed by how many electrons it has. However, when matter shrinks to nano-dimensions quantum phenomena arise; these are governed by the size of the matter. The Nobel Laureates in Chemistry 2023 have succeeded in producing particles so small that their properties are determined by quantum phenomena. The particles, which are called quantum dots, are now of great importance in nanotechnology.

“Quantum dots have many fascinating and unusual properties. Importantly, they have different colours depending on their size,” says Johan Åqvist, Chair of the Nobel Committee for Chemistry.

Physicists had long known that in theory size-dependent quantum effects could arise in nanoparticles, but at that time it was almost impossible to sculpt in nanodimensions. Therefore, few people believed that this knowledge would be put to practical use.

However, in the early 1980s, Alexei Ekimov succeeded in creating size-dependent quantum effects in coloured glass. The colour came from nanoparticles of copper chloride and Ekimov demonstrated that the particle size affected the colour of the glass via quantum effects.

A few years later, Louis Brus was the first scientist in the world to prove size-dependent quantum effects in particles floating freely in a fluid.

In 1993, Moungi Bawendi revolutionised the chemical production of quantum dots, resulting in almost perfect particles. This high quality was necessary for them to be utilised in applications.

Quantum dots now illuminate computer monitors and television screens based on QLED technology. They also add nuance to the light of some LED lamps, and biochemists and doctors use them to map biological tissue.

Quantum dots are thus bringing the greatest benefit to humankind. Researchers believe that in the future they could contribute to flexible electronics, tiny sensors, thinner solar cells and encrypted quantum communication – so we have just started exploring the potential of these tiny particles.

Read more about this year’s prize

Popular science background: They added colour to nanotechnology (pdf)
Scientific background: Quantum dots – seeds of nanoscience (pdf)

Moungi G. Bawendi, born 1961 in Paris, France. PhD 1988 from University of Chicago, IL, USA. Professor at Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.

Louis E. Brus, born 1943 in Cleveland, OH, USA. PhD 1969 from Columbia University, New York, NY, USA. Professor at Columbia University, New York, NY, USA.

Alexei I. Ekimov, born 1945 in the former USSR. PhD 1974 from Ioffe Physical-Technical Institute, Saint Petersburg, Russia. Formerly Chief Scientist at Nanocrystals Technology Inc., New York, NY, USA.


The most recent ‘quantum dot’ (a particular type of nanoparticle) story here is a January 5, 2023 posting, “Can I have a beer with those carbon quantum dots?

Proving yet again that scientists can have a bumpy trip to a Nobel prize, an October 4, 2023 news item on phys.org describes how one of the winners flunked his first undergraduate chemistry test, Note: Links have been removed,

Talk about bouncing back. MIT professor Moungi Bawendi is a co-winner of this year’s Nobel chemistry prize for helping develop “quantum dots”—nanoparticles that are now found in next generation TV screens and help illuminate tumors within the body.

But as an undergraduate, he flunked his very first chemistry exam, recalling that the experience nearly “destroyed” him.

The 62-year-old of Tunisian and French heritage excelled at science throughout high school, without ever having to break a sweat.

But when he arrived at Harvard University as an undergraduate in the late 1970s, he was in for a rude awakening.

You can find more about the winners and quantum dots in an October 4, 2023 news item on Nanowerk and in Dr. Andrew Maynard’s (Professor of Advanced Technology Transitions, Arizona State University) October 4, 2023 essay for The Conversation (h/t October 4, 2023 news item on phys.org), Note: Links have been removed,

This year’s prize recognizes Moungi Bawendi, Louis Brus and Alexei Ekimov for the discovery and development of quantum dots. For many years, these precisely constructed nanometer-sized particles – just a few hundred thousandths the width of a human hair in diameter – were the darlings of nanotechnology pitches and presentations. As a researcher and adviser on nanotechnology [emphasis mine], I’ve [Dr. Andrew Maynard] even used them myself when talking with developers, policymakers, advocacy groups and others about the promise and perils of the technology.

The origins of nanotechnology predate Bawendi, Brus and Ekimov’s work on quantum dots – the physicist Richard Feynman speculated on what could be possible through nanoscale engineering as early as 1959, and engineers like Erik Drexler were speculating about the possibilities of atomically precise manufacturing in the the 1980s. However, this year’s trio of Nobel laureates were part of the earliest wave of modern nanotechnology where researchers began putting breakthroughs in material science to practical use.

Quantum dots brilliantly fluoresce: They absorb one color of light and reemit it nearly instantaneously as another color. A vial of quantum dots, when illuminated with broad spectrum light, shines with a single vivid color. What makes them special, though, is that their color is determined by how large or small they are. Make them small and you get an intense blue. Make them larger, though still nanoscale, and the color shifts to red.

The wavelength of light a quantum dot emits depends on its size. Maysinger, Ji, Hutter, Cooper, CC BY

There’s also an October 4, 2023 overview article by Tekla S. Perry and Margo Anderson for the IEEE Spectrum about the magazine’s almost twenty-five years of reporting on quantum dots

Red blue and green dots mass in rows, with some dots moving away

Image credit: Brandon Palacio/IEEE Spectrum

Your Guide to the Newest Nobel Prize: Quantum Dots

What you need to know—and what we’ve reported—about this year’s Chemistry award

It’s not a long article and it has a heavy focus on the IEEEE’s (Institute of Electrical and Electtronics Engineers) the road quantum dots have taken to become applications and being commercialized.

Congratulations to Moungi Bawendi, Louis Brus, and Alexei Ekimov!

2022 Nobel Prize for Physics winners proved the existence of quantum entanglement

In early October 2022, Alain Aspect, John Clauser and Anton Zeilinger were jointly awarded the 2022 Nobel Prize in Physics for work each scientist performed independently of the others.

Here’s more about the scientists and their works from an October 4, 2022 Nobel Prize press release,

The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Physics 2022 to

Alain Aspect
Institut d’Optique Graduate School – Université Paris-
Saclay and École Polytechnique, Palaiseau, France

John F. Clauser
J.F. Clauser & Assoc., Walnut Creek, CA, USA

Anton Zeilinger
University of Vienna, Austria

“for experiments with entangled photons, establishing the violation of Bell inequalities and pioneering quantum information science”

Entangled states – from theory to technology

Alain Aspect, John Clauser and Anton Zeilinger have each conducted groundbreaking experiments using entangled quantum states, where two particles behave like a single unit even when they are separated. Their results have cleared the way for new technology based upon quantum information.

The ineffable effects of quantum mechanics are starting to find applications. There is now a large field of research that includes quantum computers, quantum networks and secure quantum encrypted communication.

One key factor in this development is how quantum mechanics allows two or more particles to exist in what is called an entangled state. What happens to one of the particles in an entangled pair determines what happens to the other particle, even if they are far apart.

For a long time, the question was whether the correlation was because the particles in an entangled pair contained hidden variables, instructions that tell them which result they should give in an experiment. In the 1960s, John Stewart Bell developed the mathematical inequality that is named after him. This states that if there are hidden variables, the correlation between the results of a large number of measurements will never exceed a certain value. However, quantum mechanics predicts that a certain type of experiment will violate Bell’s inequality, thus resulting in a stronger correlation than would otherwise be possible.

John Clauser developed John Bell’s ideas, leading to a practical experiment. When he took the measurements, they supported quantum mechanics by clearly violating a Bell inequality. This means that quantum mechanics cannot be replaced by a theory that uses hidden variables.

Some loopholes remained after John Clauser’s experiment. Alain Aspect developed the setup, using it in a way that closed an important loophole. He was able to switch the measurement settings after an entangled pair had left its source, so the setting that existed when they were emitted could not affect the result.

Using refined tools and long series of experiments, Anton Zeilinger started to use entangled quantum states. Among other things, his research group has demonstrated a phenomenon called quantum teleportation, which makes it possible to move a quantum state from one particle to one at a distance.

“It has become increasingly clear that a new kind of quantum technology is emerging. We can see that the laureates’ work with entangled states is of great importance, even beyond the fundamental questions about the interpretation of quantum mechanics,”says Anders Irbäck, Chair of the Nobel Committee for Physics.

There are some practical applications for their work on establishing quantum entanglement as Dr. Nicholas Peters, University of Tennessee and Oak Ridge National Laboratory (ORNL), explains in his October 7, 2022 essay for The Conversation,

Unhackable communications devices, high-precision GPS and high-resolution medical imaging all have something in common. These technologies—some under development and some already on the market all rely on the non-intuitive quantum phenomenon of entanglement.

Two quantum particles, like pairs of atoms or photons, can become entangled. That means a property of one particle is linked to a property of the other, and a change to one particle instantly affects the other particle, regardless of how far apart they are. This correlation is a key resource in quantum information technologies.

For the most part, quantum entanglement is still a subject of physics research, but it’s also a component of commercially available technologies, and it plays a starring role in the emerging quantum information processing industry.

Quantum entanglement is a critical element of quantum information processing, and photonic entanglement of the type pioneered by the Nobel laureates is crucial for transmitting quantum information. Quantum entanglement can be used to build large-scale quantum communications networks.

On a path toward long-distance quantum networks, Jian-Wei Pan, one of Zeilinger’s former students, and colleagues demonstrated entanglement distribution to two locations separated by 764 miles (1,203 km) on Earth via satellite transmission. However, direct transmission rates of quantum information are limited due to loss, meaning too many photons get absorbed by matter in transit so not enough reach the destination.

Entanglement is critical for solving this roadblock, through the nascent technology of quantum repeaters. An important milestone for early quantum repeaters, called entanglement swapping, was demonstrated by Zeilinger and colleagues in 1998. Entanglement swapping links one each of two pairs of entangled photons, thereby entangling the two initially independent photons, which can be far apart from each other.

Perhaps the most well known quantum communications application is Quantum Key Distribution (QKD), which allows someone to securely distribute encryption keys. If those keys are stored properly, they will be secure, even from future powerful, code-breaking quantum computers.

I don’t usually embed videos that are longer than 5 mins. but this one has a good explanation of cryptography (both classical and quantum),

The video host, Physics Girl (website), is also known as Dianna Cowern.

If you have the time, do read Peters’s October 7, 2022 essay, which can also be found as an October 10, 2022 news item on phys.org.

I wonder if there’s going to be a rush to fund and commercialize more quantum physics projects. There’s certainly an upsurge in activity locally and in Canada (I assume the same is true elsewhere) as my July 26, 2022 posting “Quantum Mechanics & Gravity conference (August 15 – 19, 2022) launches Vancouver (Canada)-based Quantum Gravity Institute and more” makes clear.

Donna Strickland, first female Nobel Prize winner in 55 years and one of only three (so far) in history

It’s been quite the fascinating week in the world of physics culminating with Donna Strickland’s shiny new Nobel Prize in physics.

For my purposes, this week in physics started on Friday, September 28, 2018 with Allesanndro Strumia’s presentation at CERN’s (European Particle Physics Laboratory) “1st workshop on high energy theory and gender” where he claimed and proved ‘scientifically’ that physics has become “sexist against men.” I’ll get back to Strumia in a moment but, first, let’s celebrate Donna Strickland and her achievements.

Only three women, including Strickland, in the history (117 years) of the Nobel Prize for Physics have won it, Marie Curie in 1903, Maria Goeppert Mayer in 1963, and, now, Strickland in 2018.

The University of Waterloo (Ontario, Canada) had this to say in an October 2, 2018 news release,

Donna Strickland wins Nobel Prize in Physics

Tuesday, October 2, 2018

Dr. Donna Strickland

Donna Strickland, a University of Waterloo professor who helped revolutionize laser physics, has been named a winner of this year’s Nobel Prize in Physics.

Strickland, an associate professor in the Department of Physics and Astronomy, shares half the $1.4 million prize with French laser physicist Gérard Mourou. The other half was awarded to U.S. physicist Arthur Ashkin.

The Royal Swedish Academy of Sciences stated that Mourou and Strickland paved the way toward the shortest and most intense laser pulses created by mankind. Their revolutionary article was published in 1985 and was the foundation of Strickland’s doctoral thesis.

Strickand conducted her Nobel-winning research while a PhD student under Mourou in 1989 at the University of Rochester in New York. The team’s research has a number of applications in industry and medicine.

It was great to have had the opportunity to work with one of the pioneers of ultrafast lasers, Gerard Mourou,” said Strickland. “It was a small community back then. It was a new, burgeoning field. I got to be part of that. It was very exciting.”

A Nobel committee member said billions of people make daily use of laser printers and optical scanners and millions undergo laser surgery.

“This is a tremendous day for Professor Strickland and needless to say a tremendous day for the University of Waterloo,” said Feridun Hamdullahpur, president and vice-chancellor of the University of Waterloo. “This is Waterloo’s first Nobel laureate and the first woman to receive the Nobel Prize in Physics in 55 years.”

During an interview, Strickland told the Globe and Mail [national newspaper]: “We need to celebrate women physicists because we’re out there, and hopefully in time it’ll start to move forward at a faster rate.”

Charmaine Dean, vice-president research at the University of Waterloo said: “Donna Strickland exemplifies research excellence at Waterloo. Her groundbreaking work is a testament to the importance of fundamental research as it has established the foundation for laser-based technologies that we see today from micromachining to laser eye surgery.”

An October 2, 2018 news item on Nanowerk focuses on the three winners,

Arthur Ashkin, an American physicist has been awarded half the prize for his invention of optical tweezers and their application to biological systems. His amazing tool has helped to reach the old dream of grabing [sic] particles, atoms, viruses and other living cells. The optical tweezers work with the radiation pressure of light to hold and move tiny object and are widely used to study the machinery of life.

French physicist Gérard Mourou and Canadian physicist Donna Strickland share the other half for their method of generating ultra-short and very intense optical pulses. Ultra-sharp laser beams have made possible to cut or drill holes in various materials extremely precisely – even in living matter. The technique this duo pioneered is called chirped pulse amplification or CPA and it has led to corrective eye surgeries for millions of people.

An Oct. 2, 2018 article by Marina Koren for The Atlantic is my favourite of the ones focusing on Strickland. One of Koren’s major focal points is Strickland’s new Wikipedia page (Note: Links have been removed),

It was about five in the morning in Ontario, Canada, when Donna Strickland’s phone rang. The Nobel Prize committee was on the line in Stockholm, calling to tell her she had won the prize in physics.

“We wondered if it was a prank,” Strickland said Tuesday [October 2 ,2018], in an interview with a Nobel official after the call. She had been asleep when the call arrived. “But then I knew it was the right day, and it would have been a cruel prank.”

Lasers, focused beams of light particles, were invented in the 1960s. Scientists immediately started tinkering with them, looking for ways to harness and manipulate these powerful devices.

Strickland and [Gérard] Mourou] found a way to stretch and compress lasers to produce short, intense pulses that are now used, among other things, in delicate surgeries to fix vision problems. [Arthur] Ashkin figured out a way to maneuver laser light so that it could push small particles toward the center of the beam, hold them in place, and even move them around. This technique became the delightfully named “optical tweezer.” It allowed Ashkin to use the power of light to capture and hold living bacteria and viruses without harming the organisms.

Unlike her fellow winners, Strickland did not have a Wikipedia page at the time of the announcement. A Wikipedia user tried to set up a page in May, but it was denied by a moderator with the message: “This submission’s references do not show that the subject qualifies for a Wikipedia article.” Strickland, it was determined, had not received enough dedicated coverage elsewhere on the internet to warrant a page.

On Tuesday, a newly created page flooded with edits: “Added in her title.” “Add Nobel-winning paper.” “Added names of other women Nobelists [sic] in physics.”

The construction of the Wikipedia page feels like a metaphor for a historic award process that has long been criticized for neglecting women in its selection, and for the shortage of women’s stories in the sciences at large. To scroll through the “history” tab of Strickland’s page, where all edits are recorded and tracked, is to witness in real time the recognition of a scientist whose story likely deserved attention long before the Nobel Prize committee called.

Strickland’s historic win comes a day after CERN, the European organization that operates the world’s most powerful particle accelerator, suspended a senior scientist for saying that physics was “invented and built by men.” Alessandro Strumia, a professor at the University of Pisa, made the statement during a recent speech at a seminar on gender issues in physics that was attended by mostly female physicists. Strumia said “men prefer working with things and women prefer working with people,” and that between men and women there is a “difference even in children before any social influence.” His remarks were widely circulated online and prompted fierce backlash.

The remarks don’t faze Strickland, who very publicly proved them wrong on Tuesday. In an interview with the BBC on Tuesday, she called Strumia’s claims “silly.”

For anyone curious about the Strumia situation, there’s an October 2, 2018 CBC Radio (As It Happens) online news article. Note: Links have been removed,

Not only was Alessandro Strumia being offensive when he said that physics “was invented and built by men” — he was also wrong, says physicist Jess Wade.

“Actually, women have contributed hugely to physics throughout the whole of history, but for an incredibly long time we haven’t documented or told those stories,” Wade told As It Happens host Carol Off.

And she would know. The Imperial College London research associate has made it her mission to write hundreds of Wikipedia entries about women in science and engineering.

Wade was in the room on Friday when Strumia, a physicist at Pisa University, made the inflammatory remarks during a gender workshop in Geneva, organized by the European nuclear research centre CERN.

CERN cut ties with Strumia after the BBC reported the content of his presentation.

This article includes some of the slides in Strumia’s now infamous presentation.

Tommaso Dorigo in an October 1, 2018 posting on the Science 2.0 blog offers another analysis,

The world of particle physics is in turmoil because of a presentation by Alessandro Strumia, an Italian phenomenologist, at CERN’s “1st workshop on high energy theory and gender”, and its aftermath.

By now the story has been echoed by many major newscasters around the world, and discussed in public and private forums, blogs, twitter feeds. I wanted to stay away from it here, mainly because it is a sensitive issue and the situation is still evolving, but after all, why not offer to you my personal pitch on the matter? Strumia, by the way, has been an occasional commenter to this blog – you can find some of his comments signed as “AS” in threads of past articles. Usually he makes good points here, as long as physics is the subject.

Anyway, first of all let me give you a quick recall of the events. The three-day workshop, which took place on September 26-28, was meant to”focus on recent developments in theoretical high-energy physics and cosmology, and discuss issues of gender and equal opportunities in the field“; it followed three previous events which combined string theory and gender issues. Strumia’s presentation was titled “Experimental tests of a new global symmetry“, a physicist’s way of describing the issue of man-woman equality. It is important to note that the talk was not an invited one – its author had asked the organizers for a slot as he said he would be talking of bibliometrics, and indeed his contribution was listed in the agenda of September 28 with the innocuous title “Bibliometrics data about gender issues in fundamental theory“.

Strumia’s slides contain a collection of half-baked claims, coming from his analysis of InSpire data from citations and authorship of articles in theoretical physics. I consider his talk offensive on many levels. It starts by casting the woman discrimination issue in scientific academia as a test of hypothesis of whether the “man-woman” symmetry is explicitly broken (i.e. there is no symmetry) or spontaneously broken (by a difference of treatment) – something that could even raise a smile in a geeky physicist; but the fun ends there.

Dorigo offers a detailed ‘takedown’ of Strumia’s assertions. I found the post intriguing for the insight it offers into physics. Never in a million years would I have thought this title, “Experimental tests of a new global symmetry,” would indicate a discussion on gender balance in the field of physics.

As I said in the opening, it has been quite the week in physics. On a final note, Brava to Doctor Donna Strickland!

2016 Nobel Chemistry Prize for molecular machines

Wednesday, Oct. 5, 2016 was the day three scientists received the Nobel Prize in Chemistry for their work on molecular machines, according to an Oct. 5, 2016 news item on phys.org,

Three scientists won the Nobel Prize in chemistry on Wednesday [Oct. 5, 2016] for developing the world’s smallest machines, 1,000 times thinner than a human hair but with the potential to revolutionize computer and energy systems.

Frenchman Jean-Pierre Sauvage, Scottish-born Fraser Stoddart and Dutch scientist Bernard “Ben” Feringa share the 8 million kronor ($930,000) prize for the “design and synthesis of molecular machines,” the Royal Swedish Academy of Sciences said.

Machines at the molecular level have taken chemistry to a new dimension and “will most likely be used in the development of things such as new materials, sensors and energy storage systems,” the academy said.

Practical applications are still far away—the academy said molecular motors are at the same stage that electrical motors were in the first half of the 19th century—but the potential is huge.

Dexter Johnson in an Oct. 5, 2016 posting on his Nanoclast blog (on the IEEE [Institute of Electrical and Electronics Engineers] website) provides some insight into the matter (Note: A link has been removed),

In what seems to have come both as a shock to some of the recipients and a confirmation to all those who envision molecular nanotechnology as the true future of nanotechnology, Bernard Feringa, Jean-Pierre Sauvage, and Sir J. Fraser Stoddart have been awarded the 2016 Nobel Prize in Chemistry for their development of molecular machines.

The Nobel Prize was awarded to all three of the scientists based on their complementary work over nearly three decades. First, in 1983, Sauvage (currently at Strasbourg University in France) was able to link two ring-shaped molecules to form a chain. Then, eight years later, Stoddart, a professor at Northwestern University in Evanston, Ill., demonstrated that a molecular ring could turn on a thin molecular axle. Then, eight years after that, Feringa, a professor at the University of Groningen, in the Netherlands, built on Stoddardt’s work and fabricated a molecular rotor blade that could spin continually in the same direction.

Speaking of the Nobel committee’s selection, Donna Nelson, a chemist and president of the American Chemical Society told Scientific American: “I think this topic is going to be fabulous for science. When the Nobel Prize is given, it inspires a lot of interest in the topic by other researchers. It will also increase funding.” Nelson added that this line of research will be fascinating for kids. “They can visualize it, and imagine a nanocar. This comes at a great time, when we need to inspire the next generation of scientists.”

The Economist, which appears to be previewing an article about the 2016 Nobel prizes ahead of the print version, has this to say in its Oct. 8, 2016 article,

BIGGER is not always better. Anyone who doubts that has only to look at the explosion of computing power which has marked the past half-century. This was made possible by continual shrinkage of the components computers are made from. That success has, in turn, inspired a search for other areas where shrinkage might also yield dividends.

One such, which has been poised delicately between hype and hope since the 1990s, is nanotechnology. What people mean by this term has varied over the years—to the extent that cynics might be forgiven for wondering if it is more than just a fancy rebranding of the word “chemistry”—but nanotechnology did originally have a fairly clear definition. It was the idea that machines with moving parts could be made on a molecular scale. And in recognition of this goal Sweden’s Royal Academy of Science this week decided to award this year’s Nobel prize for chemistry to three researchers, Jean-Pierre Sauvage, Sir Fraser Stoddart and Bernard Feringa, who have never lost sight of nanotechnology’s original objective.

Optimists talk of manufacturing molecule-sized machines ranging from drug-delivery devices to miniature computers. Pessimists recall that nanotechnology is a field that has been puffed up repeatedly by both researchers and investors, only to deflate in the face of practical difficulties.

There is, though, reason to hope it will work in the end. This is because, as is often the case with human inventions, Mother Nature has got there first. One way to think of living cells is as assemblies of nanotechnological machines. For example, the enzyme that produces adenosine triphosphate (ATP)—a molecule used in almost all living cells to fuel biochemical reactions—includes a spinning molecular machine rather like Dr Feringa’s invention. This works well. The ATP generators in a human body turn out so much of the stuff that over the course of a day they create almost a body-weight’s-worth of it. Do something equivalent commercially, and the hype around nanotechnology might prove itself justified.

Congratulations to the three winners!

Nanoscopy and a 2014 Nobel Prize for Chemistry

An Oct. 8, 2014 news item on Nanowerk features the 2014 Nobel Prize in Chemistry honourees,

 For a long time optical microscopy was held back by a presumed limitation: that it would never obtain a better resolution than half the wavelength of light. Helped by fluorescent molecules the Nobel Laureates in Chemistry 2014 ingeniously circumvented this limitation.

Their ground-breaking work has brought optical microscopy into the nanodimension.
In what has become known as nanoscopy, scientists visualize the pathways of individual molecules inside living cells. They can see how molecules create synapses between nerve cells in the brain; they can track proteins involved in Parkinson’s, Alzheimer’s and Huntington’s diseases as they aggregate; they follow individual proteins in fertilized eggs as these divide into embryos.

An Oct, 8, 2014 Royal Swedish Academy of Science press release, which originated the news item, expands on the ‘groundbreaking’ theme,

It was all but obvious that scientists should ever be able to study living cells in the tiniest molecular detail. In 1873, the microscopist Ernst Abbe stipulated a physical limit for the maximum resolution of traditional optical microscopy: it could never become better than 0.2 micrometres. Eric Betzig, Stefan W. Hell and William E. Moerner are awarded the Nobel Prize in Chemistry 2014 for having bypassed this limit. Due to their achievements the optical microscope can now peer into the nanoworld.

Two separate principles are rewarded. One enables the method stimulated emission depletion (STED) microscopy, developed by Stefan Hell in 2000. Two laser beams are utilized; one stimulates fluorescent molecules to glow, another cancels out all fluorescence except for that in a nanometre-sized volume. Scanning over the sample, nanometre for nanometre, yields an image with a resolution better than Abbe’s stipulated limit.

Eric Betzig and William Moerner, working separately, laid the foundation for the second method, single-molecule microscopy. The method relies upon the possibility to turn the fluorescence of individual molecules on and off. Scientists image the same area multiple times, letting just a few interspersed molecules glow each time. Superimposing these images yields a dense super-image resolved at the nanolevel. In 2006 Eric Betzig utilized this method for the first time.

Today, nanoscopy is used world-wide and new knowledge of greatest benefit to mankind is produced on a daily basis.

Here’s an image illustrating different microscopy resolutions including one featuring single-molecule microscopy,

The centre image shows lysosome membranes and is one of the first ones taken by Betzig using single-molecule microscopy. To the left, the same image taken using conventional microscopy. To the right, the image of the membranes has been enlarged. Note the scale division of 0.2 micrometres, equivalent to Abbe’s diffraction limit. Image: Science 313:1642–1645. [downloaded from http://www.kva.se/en/pressroom/Press-releases-2014/nobelpriset-i-kemi-2014/]

The centre image shows lysosome membranes and is one of the first ones taken by Betzig using single-molecule microscopy. To the left, the same image taken using conventional microscopy. To the right, the image of the membranes has been enlarged. Note the scale division of 0.2 micrometres, equivalent to Abbe’s diffraction limit. Image: Science 313:1642–1645. [downloaded from http://www.kva.se/en/pressroom/Press-releases-2014/nobelpriset-i-kemi-2014/]

The press release goes on to provide some biographical details about the three honourees and information about the financial size of the award,

Eric Betzig, U.S. citizen. Born 1960 in Ann Arbor, MI, USA. Ph.D. 1988 from Cornell University, Ithaca, NY, USA. Group Leader at Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.

Stefan W. Hell, German citizen. Born 1962 in Arad, Romania. Ph.D. 1990 from the University of Heidelberg, Germany. Director at the Max Planck Institute for Biophysical Chemistry, Göttingen, and Division head at the German Cancer Research Center, Heidelberg, Germany.

William E. Moerner, U.S. citizen. Born 1953 in Pleasanton, CA, USA. Ph.D. 1982 from Cornell University, Ithaca, NY, USA. Harry S. Mosher Professor in Chemistry and Professor, by courtesy, of Applied Physics at Stanford University, Stanford, CA, USA.

Prize amount: SEK 8 million, to be shared equally between the Laureates.

The amount is in Swedish Krona. In USD, it is approximately $1.1M; in CAD, it is approximately $1.2M; and, in pounds sterling (British pounds), it is approximately £689,780.

Congratulations to all three gentlemen!

ETA Oct. 14, 2014: Azonano features an Oct. 14, 2014 news item from the UK’s National Physical Laboratory (NPL)  congratulating the three recipients of the 2014 Nobel Prize for Chemistry. The item also features a description of the recipients’ groundbreaking work along with an update on how this pioneering work has influenced and inspired further research in the field of nanoscopy at the NPL.

Peter Higgs and François Englert to receive 2013 Nobel Prize in Physics and TRIUMF name changes?

After all the foofaraw about finding/confirming the existence of the Higgs Boson or ‘god’ particle (featured in my July 4, 2012 posting amongst many others), the Royal Swedish Academy of Sciences has decided to award the 2013 Nobel prize for Physics to two of the individuals responsible for much of the current thinking about subatomic particles and mass (from the Oct. 8, 2013 news item on ScienceDaily),

The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Physics for 2013 to François Englert of Université Libre de Bruxelles, Brussels, Belgium, and Peter W. Higgs of the University of Edinburgh, UK, “for the theoretical discovery of a mechanism that contributes to our understanding of the origin of mass of subatomic particles, and which recently was confirmed through the discovery of the predicted fundamental particle, by the ATLAS and CMS experiments at CERN’s Large Hadron Collider.”

François Englert and Peter W. Higgs are jointly awarded the Nobel Prize in Physics 2013 for the theory of how particles acquire mass. In 1964, they proposed the theory independently of each other (Englert together with his now deceased colleague Robert Brout). In 2012, their ideas were confirmed by the discovery of a so called Higgs particle at the CERN laboratory outside Geneva in Switzerland.

TRIUMF, sometimes known as Canada’s national laboratory for particle and nuclear physics, has issued an Oct. 8, 2013 news release,

HIGGS, ENGLERT SHARE 2013 NOBEL PRIZE IN PHYSICS

Canadians Key Part of Historical Nobel Prize to “Godfathers” of the “God Particle”

(Vancouver, BC) — The Royal Swedish Academy of Sciences today awarded the Nobel Prize in physics to Professor Peter W. Higgs (Univ. of Edinburgh) and Professor François Englert (Univ. Libre de Bruxelles) to recognize their work developing the theory of what is now known as the Higgs field, which gives elementary particles mass.  Canadians have played critical roles in all stages of the breakthrough discovery Higgs boson particle that validates the original theoretical framework.  Throngs across Canada are celebrating.

More than 150 Canadian scientists and students at 10 different institutions are presently involved in the global ATLAS experiment at CERN.  Canada’s national laboratory for particle and nuclear physics, TRIUMF, has been a focal point for much of the Canadian involvement that has ranged from assisting with the construction of the LHC accelerator to building key elements of the ATLAS detector and hosting one of the ten global Tier-1 Data Centres that stores and processes the physics for the team of thousands.

“The observation of a Higgs Boson at about 125 GeV, or 130 times the mass of the proton, by both the ATLAS and CMS groups is a tremendous achievement,” said Rob McPherson, spokesperson of the ATLAS Canada collaboration, a professor of physics at the University of Victoria and Institute of Particle Physics scientist. “Its existence was predicted in 1964 when theorists reconciled how massive particles came into being.  It took almost half a century to confirm the detailed predictions of the theories in a succession of experiments, and finally to discover the Higgs Boson itself using our 2012 data.”

The Brout-Englert-Higgs (BEH) mechanism was first proposed in 1964 in two papers published independently, the first by Belgian physicists Robert Brout and François Englert, and the second by British physicist Peter Higgs. It explains how the force responsible for beta decay is much weaker than electromagnetism, but is better known as the mechanism that endows fundamental particles with mass. A third paper, published by Americans Gerald Guralnik and Carl Hagen with their British colleague Tom Kibble further contributed to the development of the new idea, which now forms an essential part of the Standard Model of particle physics. As was pointed out by Higgs, a key prediction of the idea is the existence of a massive boson of a new type, which was discovered by the ATLAS and CMS experiments at CERN in 2012.

The next step will be to determine the precise nature of the Higgs particle and its significance for our understanding of the universe. Are its properties as expected for the Higgs boson predicted by the Standard Model of particle physics? Or is it something more exotic? The Standard Model describes the fundamental particles from which we, and every visible thing
in the universe, are made, and the forces acting between them. All the matter that we can see, however, appears to be no more than about 4% of the total. A more exotic version of the Higgs particle could be a bridge to understanding the 96% of the universe that remains obscure.

TRIUMF salutes Peter Higgs and François Englert for their groundbreaking work recognized by today’s Nobel Prize and congratulates the international team of tens of thousands of scientists, engineers, students, and many more from around the world who helped make the discovery.

For spokespeople at the major Canadian universities involved in the Higgs discovery, please see the list below:

CANADIAN CONTACTS

U of Alberta: Doug Gingrich, gingrich@ualberta.ca, 780-492-9501
UBC:  Colin Gay, cgay@physics.ubc.ca, 604-822-2753
Carleton U: Gerald Oakham (& TRIUMF), oakham@physics.carleton.ca, 613-520-7539
McGill U: Brigitte Vachon (also able to interview in French), vachon@physics.mcgill.ca, 514-398-6478
U of Montreal: Claude Leroy (also able to interview in French),leroy@lps.uontreal.ca, 514-343-6722
Simon Fraser U: Mike Vetterli (& TRIUMF, also able to interview in French), vetm@triumf.ca, 778-782-5488
TRIUMF: Isabel Trigger (also able to interview in French), itrigger@triumf.ca, 604-222-7651
U of Toronto: Robert Orr, orr@physics.utoronto.ca, 416-978-6029
U of Victoria: Rob McPherson, rmcphers@triumf.ca, 604-222-7654
York U: Wendy Taylor, taylorw@yorku.ca, 416-736-2100 ext 77758

While I know Canadians have been part of the multi-year, multi-country effort to determine the existence or non-existence of the Higgs Boson and much more in the field of particle physics, I would prefer we were not described as “… Key Part of Historical Nobel Prize … .” The question that springs to mind is: how were Canadian efforts key to this work? The answer is not revealed in the news release, which suggests that the claim may be a little overstated. On the other hand, I do like the bit about ‘saluting Higgs and Englert for their groundbreaking work’.

As for TRIUMF and what appears to be a series of name changes, I’m left somewhat puzzled, This Oct. 8, 2013 news release bears the name (or perhaps it’s a motto or tagline of some sort?): TRIUMF — Accelerating Science for Canada, meanwhile the website still sports this: TRIUMF Canada’s national laboratory for particle and nuclear physics while a July 17, 2013 TRIUMF news release gloried in this name: TRIUMF Accelerators, Inc., (noted in my July 18, 2013 posting). Perhaps TRIUMF is trying to follow in CERN’s footsteps. CERN was once known as the ‘European particle physics laboratory’ but is now known as the European Organization for Nuclear Research and seems to also have the tagline: ‘Accelerating science’.