Tag Archives: Scientific American

Nanomedicine: two stories about wound healing

Different strokes for different folks or, in this case, somewhat different approaches to healing different wounds.

Infected wounds

A July 17, 2024 news item on Nanowerk highlights work from China’s Research Center for Neutrophil Engineering Technology (affiliated with Suzhou Hospital of Nanjing Medical University), Note: A link has been removed,

Infectious wounds represent a critical challenge in healthcare, especially for diabetic patients grappling with ineffective antibiotics and escalating drug resistance. Conventional therapies often inadequately address deep tissue infections, highlighting the need for more innovative solutions. Engineered nanovesicles (NVs) from activated neutrophils provide a precise mechanism to combat pathogens deeply embedded in tissues, potentially revolutionizing the management of complex infectious wounds and boosting overall treatment efficacy.

Researchers at the Research Center for Neutrophil Engineering Technology have achieved a significant advancement in medical nanotechnology. Their findings, published in the journal Burns & Trauma (“Engineered nanovesicles from activated neutrophils with enriched bactericidal proteins have molecular debridement ability and promote infectious wound healing”), detail the creation of novel neutrophil-engineered NVs.

A July 17, 2024 Maximum Academic Press ‘press release’ on EurekAlert, which originated the news item, goes on to describe what the researchers discovered,

This study reveals that engineered NVs derived from activated neutrophils not only mimic the physical properties of exosomes but surpass them due to their rich content of bactericidal proteins. Extensively tested both in vitro and in vivo, these NVs effectively combat key pathogens like Staphylococcus aureus and Escherichia coli, which contribute to deep tissue infections. The NVs promote rapid debridement, significantly reduce bacterial populations, and boost collagen deposition, thus hastening the healing process. This research positions NVs as a formidable alternative to traditional antibiotics, introducing a novel method for treating resistant infections and advancing the field of wound care.

Dr. Bingwei Sun, the lead researcher, emphasized, “These engineered NVs mark a major advancement in the management of infectious diseases. By targeting the infection site with high levels of bactericidal proteins, we achieve swift and effective healing, thereby opening new paths for the treatment of chronic and resistant infections.”

The advent of activated neutrophil-derived NVs signifies a major leap in medical technology, potentially reducing healthcare costs and enhancing patient outcomes. This innovation not only promises to improve wound healing in diabetic and other chronic infection patients but also sets the stage for further development of biologically inspired therapeutic strategies.

Here’s a link to and a citation for the paper,

Engineered nanovesicles from activated neutrophils with enriched bactericidal proteins have molecular debridement ability and promote infectious wound healing by Hangfei Jin, Xiao Wen, Ran Sun, Yanzhen Yu, Zaiwen Guo, Yunxi Yang, Linbin Li, and Bingwei Sun. Burns & Trauma, Volume 12, 2024, tkae018, DOI: https://doi.org/10.1093/burnst/tkae018 Published: 20 June 2024

This paper is open access.

Diabetic wounds

A July 17, 2024 news item on phys.org announces work from another team developing its own approach to healing wounds, albeit, a different category of wounds,

Diabetic wounds are notoriously challenging to treat, due to prolonged inflammation and a high risk of infection. Traditional treatments generally offer only passive protection and fail to dynamically interact with the wound environment.

In a new article published in Burns & Trauma on June 5, 2024, a research team from Mudanjiang Medical University and allied institutions assesses the effectiveness of PLLA nanofibrous membranes.

Infused with curcumin and silver nanoparticles, these membranes are designed to substantially enhance the healing processes in diabetic wounds by targeting fundamental issues like excessive inflammation and infection.

This research centered on developing PLLA/C/Ag nanofibrous membranes through air-jet spinning, achieving a consistent fiber distribution essential for effective therapeutic delivery. The membranes boast dual benefits: antioxidant properties that reduce harmful reactive oxygen species in wound environments and potent antibacterial activity that decreases infection risks.

A July 17, 2024 Maximum Academic Press ‘press release‘ on EurekAlert provides more information about the research, Note 1: This press release appears to have originated the news item, which was then edited and rewritten; Note 2: Links have been removed,

In a pioneering study, researchers have developed a poly (L-lactic acid) (PLLA) nanofibrous membrane enhanced with curcumin and silver nanoparticles (AgNPs), aimed at improving the healing of diabetic wounds. This advanced dressing targets critical barriers such as inflammation, oxidative stress, and bacterial infections, which hinder the recovery process in diabetic patients. The study’s results reveal a promising therapeutic strategy that could revolutionize care for diabetes-related wounds.

Diabetic wounds are notoriously challenging to heal, with prolonged inflammation and a high risk of infection. Traditional treatments generally offer only passive protection and fail to dynamically interact with the wound environment. The creation of bioactive dressings like the poly (L-lactic acid) (PLLA) nanofibrous membranes incorporated with AgNPs and curcumin (PLLA/C/Ag) membranes signifies a crucial shift towards therapies that actively correct imbalances in the wound healing process, offering a more effective solution for managing diabetic wounds.

Published (DOI: 10.1093/burnst/tkae009) in Burns & Trauma on June 5, 2024, this trailblazing research by a team from Mudanjiang Medical University and allied institutions assesses the effectiveness of PLLA nanofibrous membranes. Infused with curcumin and silver nanoparticles, these membranes are designed to substantially enhance the healing processes in diabetic wounds by targeting fundamental issues like excessive inflammation and infection.

This research centered on developing PLLA/C/Ag nanofibrous membranes through air-jet spinning, achieving a consistent fiber distribution essential for effective therapeutic delivery. The membranes boast dual benefits: antioxidant properties that reduce harmful reactive oxygen species in wound environments and potent antibacterial activity that decreases infection risks. In vivo tests on diabetic mice demonstrated the membranes’ capability to promote crucial healing processes such as angiogenesis and collagen deposition. These findings illustrate that PLLA/C/Ag membranes not only protect wounds but also actively support and expedite the healing process, marking them as a significant therapeutic innovation for diabetic wound management with potential for broader chronic wound care applications.

Dr. Yanhui Chu, a principal investigator of the study, highlighted the importance of these developments: “The PLLA/C/Ag membranes are a significant breakthrough in diabetic wound care. Their ability to effectively modulate the wound environment and enhance healing could establish a new standard in treatment, providing hope to millions affected by diabetes-related complications.”

The deployment of PLLA/C/Ag nanofibrous membranes in clinical environments could transform the treatment of diabetic wounds, offering a more active and effective approach. Beyond diabetes management, this technology has the potential for extensive applications in various chronic wounds, paving the way for future breakthroughs in bioactive wound dressings. This study not only progresses our understanding of wound management but also paves new paths for developing adaptive treatments for complex wound scenarios.

Here’s a link to and a citation for the paper,

Immunomodulatory poly(L-lactic acid) nanofibrous membranes promote diabetic wound healing by inhibiting inflammation, oxidation and bacterial infection by Yan Wu, Jin Zhang, Anqi Lin, Tinglin Zhang, Yong Liu, Chunlei Zhang, Yongkui Yin, Ran Guo, Jie Gao, Yulin Li, and Yanhui Chu. Burns & Trauma, Volume 12, 2024, tkae009, DOI: https://doi.org/10.1093/burnst/tkae009 Published: 05 June 2024

This paper is open access.

Science publishing

As I think most people know, publishing of any kind is a tough business, particularly these days. This instability has led to some interesting corporate relationships. E.g., Springer Nature (a German-British academic publisher) is the outcome of some mergers as the Springer Nature Wikipedia entry notes,

The company originates from several journals and publishing houses, notably Springer-Verlag, which was founded in 1842 by Julius Springer in Berlin[4] (the grandfather of Bernhard Springer who founded Springer Publishing in 1950 in New York),[5] Nature Publishing Group which has published Nature since 1869,[6] and Macmillan Education, which goes back to Macmillan Publishers founded in 1843.[7]

Springer Nature was formed in 2015 by the merger of Nature Publishing Group, Palgrave Macmillan, and Macmillan Education (held by Holtzbrinck Publishing Group) with Springer Science+Business Media (held by BC Partners). Plans for the merger were first announced on 15 January 2015.[8] The transaction was concluded in May 2015 with Holtzbrinck having the majority 53% share.[9]

Now you have what was an independent science journal, Nature, owned by Springer. By the way, Springer Nature also acquired Scientific American, another major science journal.

Relatedly, seeing Maximum Academic Press as the issuer for the press releases mentioned here aroused my curiosity. I haven’t stumbled across the company before but found this on the company’s About Us webpage, Note: Links have been removed,

Maximum Academic Press (MAP) is an independent publishing company with focus on publishing golden open access academic journals. From 2020 to now, MAP has successfully launched 24 academic journals which cover the research fields of agriculture, biology, environmental sciences, engineering and humanities and social sciences.                    

Professor Zong-Ming (Max) Cheng, chief editor and founder of MAP, who earned his Ph.D from Cornell University in 1991 and worked as an Assistant, Associate and Professor at North Dakota State University and University of Tennessee for over 30 years. Prior to establishing MAP, Dr. Cheng launched Horticulture Research (initially published by Nature Publishing Group) in 2014, Plant Phenomics (published by American Association of Advancement of Sciences, AAAS) in 2019, and BioDesign Research (published by AAAS) in 2020, and served as the Editor-in-Chief, Co-Editors-in-Chief, and the executive editor, respectively. Dr. Cheng wishes to apply all successful experiences in launching and managing these three high quality journals to MAP-published journals with highest quality and ethics standards.

It was a little bit of a surprise to see that MAP doesn’t publish the journal, Burns & Trauma, where the studies (cited here) were published. From the Burns & Trauma About the Journal webpage on the Oxford University Press website for Oxford Academic journals,

Aims and scope

Burns & Trauma is an open access, peer-reviewed journal publishing the latest developments in basic, clinical, and translational research related to burns and traumatic injuries, with a special focus on various aspects of biomaterials, tissue engineering, stem cells, critical care, immunobiology, skin transplantation, prevention, and regeneration of burns and trauma injury.

Society affiliations

Burns & Trauma is the official journal of Asia-Pacific Society of Scar Medicine, Chinese Burn Association, Chinese Burn Care and Rehabilitation Association and Chinese Society for Scar Medicine. It is sponsored by the Institute of Burn Research, Southwest Hospital (First Affiliated Hospital of Army Medical University), China.

I don’t know what to make of it all but I can safely say scientific publishing has gotten quite complicated since the days that Nature first published its own eponymous journal.

Lost Women of Science

Both an organization and a podcast series, Lost Women of Science is preparing for its second, third, and fourth podcasts seasons thanks to a grant announced in a November 19, 2021 Lost Women of Science news release (on Cision),

 Journalist and author Katie Hafner, and bioethicist Amy Scharf, today announced that the Lost Women of Science podcast series will continue for an additional three seasons thanks to a grant award of $446,760 from the Gordon and Betty Moore Foundation. The podcast series will continue its partnership with public media organization PRX and the award-winning Scientific American magazine.

The first season features multiple in-depth episodes centered on Dr. Dorothy Andersen, a pediatric pathologist who identified and named cystic fibrosis in 1938. Three episodes are now available across all major podcast listening platforms, including Apple Podcasts, Google Podcasts, Spotify, Stitcher, and Amazon Music. The fourth episode [I believe it’s Season 1] will be released on Thanksgiving Day [November 25, 2021].

Genny Biggs, Special Projects Officer of the Gordon and Betty Moore Foundation said, “We have been excited about this project from our initial conversations and have been pleased to see the results. Our history books have unfortunately taught us too little about these women and we support bringing their stories to the forefront. We hope they will inspire the next generation of female scientists.”

Hafner said, “The response to the podcast so far has been overwhelmingly positive.  We could not be more grateful to the Gordon and Betty Moore Foundation, not only for early funding to help us get started, but for continued support and confidence that will allow us to tell more stories.”

Dr. Maria Klawe, President of Harvey Mudd College and Chair of the Lost Women of Science Initiative Advisory Board, said, “It’s wonderful that the Gordon and Betty Moore Foundation recognizes that women have been making great contributions to science for centuries, even though they’re often not recognized. And the rich storytelling approach has deep impact in helping people understand the importance of a scientist’s work.”

Earlier funding for Lost Women of Science has come from the Gordon and Betty Moore Foundation, Schmidt Futures and the John Templeton Foundation. The Initiative is also partnering with Barnard College at Columbia University, one-third of whose graduates are STEM majors. Harvey Mudd College graciously served as an early Fiscal Sponsor.

To learn more about the Lost Women of Science Initiative, or to donate to this important work, please visit: www.lostwomenofscience.org and follow @lostwomenofsci.

About Lost Women of Science:

The Lost Women of Science Initiativeis a 501(c)3 nonprofit with two overarching and interrelated missions: to tell the story of female scientists who made groundbreaking achievements in their fields, yet remain largely unknown to the general public, and to inspire girls and young women to pursue education and careers in STEM. The Initiative’s flagship is its Lost Women of Science podcast series. As a full, mission-driven organization, the Lost Women of Science Initiative plans to digitize and archive its research, and to make all primary source material available to students and historians of science.

About the Gordon and Betty Moore Foundation:

The Gordon and Betty Moore Foundation fosters path-breaking scientific discovery, environmental conservation, patient care improvements and preservation of the special character of the Bay Area. Visit Moore.org and follow @MooreFound.

You can listen to this trailer for Season 1,

The four episodes currently available constitute a four-part series on Dorothy Andersen, her work, and how she got ‘lost’. You can find the podcasts here.

Thank you to the publicist who sent the announcement about the grant!

American Association for the Advancement of Science 2016 Mass Media Fellows program is open for submissions

Before getting to the latest information for applying, Matt Miller has written an exuberant and enticing  description of his experiences as a 2016 American Association for the Advancement of Science (AAAS) Mass Media Fellow for Slate.com in his Oct. 17, 2016 article for them (Note: Links have been removed),

If you’ve ever wanted to write for Slate (or other major media organizations), now is your chance—provided you’re a graduate student or postdoc in science, math, engineering, or medicine [enrolled in a university and with a US citizenship or visa that allows you to receive paymet for work].* The American Association for the Advancement of Science will soon be opening applications for its 2017 Mass Media Fellowship. Along with Slate, publications like Wired, Scientific American, NPR [National Public Radio], and the Los Angeles Times will be hosting fellows who will work as science writers for 10 weeks starting in June of next year.

..

While many of my classmates were drawing blood and administering vaccines [Miller is a student in a School of Veterinary Medicine], I flew up to New York and started learning how to be a journalist. In Slate’s Brooklyn office, I read the abstracts of newly released journal articles and pitched countless story ideas. I drank lots of coffee, sat in on editorial meetings, and interviewed scientists from almost every field imaginable (entomologists are the best). Perhaps the highlight of the whole summer was being among the first to cover the rising cost of EpiPens, a scandal that has recently led to a congressional hearing.

A large part of what I did this summer involved explaining the scientific fundamentals behind the research and making the findings more accessible and exciting to a general audience. Science writing involves a great deal of translation; scientists often get so tied up in the particulars of their research—exactly how an enzyme cleaves this protein, or whether a newly discovered bird is technically a new species—that they forget to talk about the wider societal implications their research might have on culture and civilization. But science writing also matters for the same reason all journalism matters. Science journalism can play the important role of watchdog, holding the powerful accountable and airing out things that don’t quite seem right.

You can find the application here. Don’t forget to read the eligibility rules (no students enrolled in English, journalism, science journalism, or other non-technical fields need apply).

Good luck!

*ETA Oct. 18, 2016 9:52 am PDT: The deadline for applications is midnight EST Jan. 15, 2017.

Is it Nature or is it Henry Gee? science’s woman wars continue (or start up again)

I was thinking we’d get a few more months before another ‘how women are treated in science circles’ or gender issues (as it is sometimes known) story erupted. Our last cycle was featured in my Oct. 18, 2013 posting and mentioned again in my Dec. 31, 2013 posting titled: 2013: women, science, gender, and sex. (Note: I will be referring to these postinsg and the Oct. scandals again in this posting but first, I have to lay the groundwork.)

It seems Henry Gee, a senior editor at Nature magazine, disagreed with my preference for waiting a few more months and decided to start a new cycle on Jan. 17, 2014 when he outed (revealed her personal name) pseudonymous blogger and online presence, Dr. Isis, on his Twitter feed. Here’s the nature (pun noted) of the offence (from Michael Eisen’s Jan. 20, 2014 posting on his ‘it is NOT junk’ blog),

DrIsisHenryGeeIn addition to  Dr. Isis’ personal name, Gee describes her as an “inconsequential sports physio” which seems to have disturbed some folks at least as much as the outing. Dr. Isis describes herself this way (from the Isis the Scientist blog About page,

Dr. Isis is an exercise physiologist at a major research university working on some terribly impressive stuff. …

In the Jan. 20, 2014 posting on her blog, Dr. Isis responds to Gee’s action on Twitter (partial excerpt from the posting; Note: Links have been removed),

So, while I am “ok”, were his actions “ok?” Of course not, and they give me pause. I have undoubtedly been vocal over the last four years of the fact that I believe Nature, the flagship of our profession, does not have a strong track record of treating women fairly. I believe that Henry Gee, a representative of the journal, is responsible for some of that culture.  That’s not “vitriolic” and it’s not “bullying”. That is me saying, as a woman, that there is something wrong with how this journal and its editors engage 50% of the population (or 20% of scientists) and I believe in my right to say “this is not ‘ok’.”  Henry Gee responded by skywriting my real name because he believed that would hurt me personally – my career, my safety, my family. Whatever. Regardless of the actual outcome, the direct personal nature of the attack is highlighted by its support from some that I “had it coming.. [emphasis mine]

Henry Gee’s actions were meant to intimidate me into silence. He took this approach likely with the thought that it was the most powerful way he could hurt me. Nothing more. Although I am ok, there are some recent victims of outing behavior that are not. That’s frightening. To think that the editor of a journal would respond to criticism of his professional conduct regarding the fair treatment of women by attempting to personally injure and damage..

I recommend reading the post in it’s entirety as she also addresses the adjective, ‘inconsequential’ and expands further on the issues she has with Nature (magazine). As for the emphasis I”ve added to the phrase “… I have it coming …”, it reminded me of this passage in my Dec. 31, 2013 posting,

think we (men and women) are obliged to take good look at sexism around us and within us and if you still have any doubts about the prevalence of sexism and gender bias against women, take a look at Sydney Brownstone’s Oct. 22, 2013 article for Fast Company,

These ads for U.N. Women show what happens if you type things like “women need to” into Google. The autocomplete function will suggest ways to fill in the blank based on common search terms such as “know their place” and “shut up.”

A quick, unscientific study of men-based searches comes up with very different Autocomplete suggestions. Type in “men need to,” and you’ll get “feel needed,” “grow up,” or “ejaculate.” Type in “men shouldn’t,” and you might get, “wear flip flops.”

Those searches were made in March 2013.

Gee managed to fuse two prevailing attitudes toward women in a single tweet, rage when women aren’t ‘nice’ or ‘don’t know their place’ (apparently, Dr. Isis can be quite stinging in her criticisms and so he outs her) and dismissiveness (she’s an “inconsequential sports physio”) while showcasing Nature’s (his employer) and by extension his own importance in the world of science (“Nature quakes in its boots”).

Michael Eisen in his Jan. 20, 2014 posting explains why he thinks this situation is important and unpacks some of the reasons why a young scientist might wish to operate with a pseudonym (Note: A link has been removed),

Gee and Dr. Isis have apparently had issues in the past. I don’t know the full history, but I was witness to some of it after Gee published a misogynistic short story in Nature several years back. Gee behaved like an asshole back then, and apparently he has not stopped.

Think about what happened here. A senior figure at arguably the most important journal in science took it upon himself to reveal the name of a young, female, Latina scientist with whom he has fought and whom he clearly does not like. …

Having myself come under fairly withering criticism from Dr. Isis, I feel somewhat qualified to speak to this. She has a sharp tongue. She speaks with righteous indignation. I don’t always think she’s being fair. And, to be honest, her words hurt. But you know what? She was also right. I have learned a lot from my interactions with Dr. Isis – albeit sometimes painfully. I reflected on what she had to say – and why she was saying it. I am a better person for it. I have to admit that her confrontational style is effective.

If our conflicts had existed in the “real world” where I’m a reasonably well known, male tenured UC [University of California] Berkeley professor and HHMI  [Howard Hughes Medical Institute] Investigator and she’s a young, female, Latina woman at the beginning of her research career, the deck is stacked against her. Whatever the forum, odds are I’m going to come out ahead, not because I’m right, but because that’s just the way this world works. And I think we can all agree that this is a very bad thing. This kind of power imbalance is toxic and distorting. It infuses every interaction. The worst part of it is obvious – it serves to keep people who start down, down. But it also gives people on the other side the false sense that they are right. It prevents them from learning and growing.

But when my interlocutor is anonymous, the balance of power shifts. Not completely. But it does shift. And it was enough, I think, to fundamentally change the way the conversations ended. And that was a good thing. I know I’m not going to convince many people that they should embrace this feeling of discomfort – this loss of power. But I hope, at least, people can appreciate why some amongst us feel so strongly about protecting this tool in their arsenal, and why what Gee did is more fundamental and reprehensible than the settling of a grudge.

I recommend reading Eisen’s posting in its entirety and this Jan. 21, 2014 posting by Dr. Julienne Rutherford on her Biological ANthropology Developing Investigators Troop blog. She provides more context for this situation and a personal perspective as an untenured professor herself (Note: Links have been removed),

As a biological anthropologist working toward tenure, a paper in Nature could “make” my career. I have as-yet-untenured colleagues at Ivies who get tsked-tsked for NOT submitting to Nature. The reverence for impact factors requires us to consider this the pinnacle of scientific publishing, at the same time that senior representatives of that very same journal with public platforms show absolutely no shame in trivializing our efforts as scientists or our very real struggles as outsiders in the Old White Boys Club. Struggles that make me feel like this a lot, and I actually have it pretty easy.

This continued outsider existence is what leads many to seek the clearly imperfect protection of an online pseudonym. Pseudonymity on the the internet has a long and defensible history, largely as protection of some kind, often against reprisals by employers. Sometimes as protection against cyber-stalking and sometimes real-life stalking and physical assault. But another reason is that it can offer protection against the clubbishness and bullying of privileged scholars with powers to hire, publish, grant funds. The power to deem one as a scientist of consequence. The power to refuse the pervasive poison that is their privilege and blindness. …

Interestingly, the same day Gee lashed out at Dr. Isis, Nature issued an apology for a letter they had recently published. Here’s an excerpt from the letter that was published online on Jan. 15, 2014,

Research: Publish on the basis of quality, not gender by Lukas Koube. Nature 505, 291 (16 January 2014) doi:10.1038/505291e Published online 15 January 2014

The publication of research papers should be based on quality and merit, so the gender balance of authors is not relevant in the same way as it might be for commissioned writers (see Nature 504, 188; 2013) [a special issue on women and gender issues in science]. Neither is the disproportionate number of male reviewers evidence of gender bias. …

Koube’s letter is behind a paywall but i gather the rest of it continues in a similarly incendiary and uninformed fashion.

Kelly Hills writes about the letter and Nature’s apology in a Jan. 17, 2014 posting on her Life As An Extreme Sport blog (Note: Links have been removed),

While Nature’s apology is better than a nonpology, it’s not actually a full apology, and it doesn’t surprise me that it’s not being as well-received as the editors likely hoped. I detailed some of my issues with the apology on Twitter this morning, but I wanted to take the time to actually expand on what is necessary for a complete apology.

You can find quite a few different opinions on what constitutes an actual apology. I am fond of a four stage approach: Recognition, Responsibility, Remorse/Regret, Remedy. I think it’d be easiest to go through each of these and the Nature apology, to see where they succeed, and where they fail. Hopefully this will be illustrative not only to them now, but others in the future.

… When you recognize your mistake, you need to be specific. This is what Nature said:

On re-examining the letter and the process, we consider that it adds no value to the discussion and unnecessarily inflames it, that it did not receive adequate editorial attention, and that we should not have published it.

This isn’t a bad start. Ultimately, there is recognition that the commentary was inflammatory and it shouldn’t have been published. That said, what would have made it a good example of recognition is acknowledgement that the commentary that was published was offensive, as well. It’s not about adding no value, or even being inflammatory–it’s that it’s a point of view that has been systematically deconstructed and debunked over years, to the point that people who hold it are actually advocating biased, if not complete misogynistic, positions.

I found this a very interesting read as Hills elucidates on one of my pet peeves, the non apology apology and something I recognize as one of my own faults, offering a non apology, i.e., offering excuses for my behaviour along with “I’m sorry.”

Before finishing this post, I want to include a little more information about Henry Gee (from his Wikipedia essay; Note: Links have been removed),

Dr Henry Gee (born 1962 in London, England) is a British paleontologist and evolutionary biologist. He is a senior editor of Nature, the scientific journal.[1]

Gee earnt his B.Sc. at the University of Leeds and completed his Ph.D. at Fitzwilliam College, Cambridge, where, in his spare time, he played keyboard for a jazz band fronted by Sonita Alleyne, who went on to establish the TV and radio production company Somethin’ Else.[2] Gee joined Nature as a reporter in 1987 and is now Senior Editor, Biological Sciences.[citation needed] He has published a number of books, including Before the Backbone: Views on the Origin of the Vertebrates (1996), In Search of Deep Time (1999),[3][4] A Field Guide to Dinosaurs (illustrated by Luis Rey) (2003) and Jacob’s Ladder (2004).

On January 17th, 2014, Gee became embroiled in internet controversy by revealing the identity of an anonymous science blogger, Melissa Bates [7]. Bates was an open critic of the scientific journal Nature, where Gee is a senior editor. Gee’s comments were an apparent attempt to discredit the blogger’s reputation, but many felt his doxing went too far[8] . It was later revealed that Gee is not unfamiliar with pseudonyms himself, using the pseudonym “Cromercrox” to curate his own Wikipedia entry.

I am a bit surprised by the lack of coverage on the Guardian science blogs where a number of essays were featured during the Oct. 2013 ‘sex scandals’. Perhaps no one has had enough time to write it up or perhaps the Guardian editors feel that enough has been written about gender and science. Note, Henry Gee writes for the Guardian.

It’s hard for me to tell whether or not Henry Gee’s Twitter feed (@HenryGeeBooks) is a personal account or a business account  (access seems to be restricted as of Jan. 22, 2014 12:40 pm PDT; you can access this) but it does seem that Gee has conflated his professional and personal lives in such a way that one may not be easily distinguishable from the other. This does leave me with a question, is Nature responsible for comments made on their employee’s personal Twitter feed (assuming HenryGeeBooks is a personal feed)?  No and yes.

As far as I’m concerned no employer has a right to control any aspects of an employee’s personal life unless it impacts their work, e.g. pedophiles should not be employed to work with young children. In Henry Gee’s case he invoked his employer and his professional authority as one of their editors with “Nature quakes in its boots” and that means I expect to see some sort of response from NPG .

I’ve mentioned the October 2013 scandals because Nature Publishing Group (NGP) owns Scientific American, one of the publications that was at the centre of the scandals. Their (Scientific American/NPG) response was found to be lacking that time too. At this point, we have two responses that are lacking (the excuses over the Scientific American aspects of the October 2013 scandals and the apology over the Koube letter published in January 2014) and a nonresponse with regard to Gee’s tweet.

Regarding Henry Gee, perhaps this massive indignation which has caused his Twitter page to be made inaccessible, at this time  will also cause him to reconsider his attitudes about women and about the power he wields (or wielded?). I fear that won’t be the case and that he’s more likely to be building resentment. Ultimately, this is what confounds me about these situations, how does one confront a bully without driving them into more extreme forms of the behaviour and attitudes that led to the confrontation? I don’t believe there’s ‘a one size fits all’ answer to this, I just wish there was more discussion about the issue. I speak here as a Canadian who is still haunted by L’École Polytechnique massacre in Montréal (from the Wikipedia essay; Note: Links have been removed),

The École Polytechnique Massacre, also known as the Montreal Massacre, occurred on December 6, 1989 at the École Polytechnique in Montreal, Quebec, Canada. Twenty-five-year-old Marc Lépine, armed with a legally obtained Mini-14 rifle and a hunting knife, shot twenty-eight people before killing himself. He began his attack by entering a classroom at the university, where he separated the male and female students. After claiming that he was “fighting feminism” and calling the women “a bunch of feminists,” he shot all nine women in the room, killing six. He then moved through corridors, the cafeteria, and another classroom, specifically targeting women to shoot. Overall, he killed fourteen women and injured ten other women and four men in just under twenty minutes before turning the gun on himself.[1][2]

I applaud the women who have spoken up and continue to speak up and I hope we all men and women can work towards ways of confronting bullies while also allowing for the possibility of change.

Finally, thanks to Susan Baxter for alerting me to this latest gender and science story cycle. Here’s Susan’s blog where she writes about medical matters (mostly). Her latest post concern’s Lyme’s disease.