Tag Archives: US Department of Agriculture (USDA)

Cotton gin waste and self-embedding silver nanoparticles

This work may lead to new uses for cotton waste products according to an April 10, 2024 news item on phys.org,

Cotton gin waste, also known as cotton gin trash, is a byproduct of the cotton ginning process and occurs when the cotton fibers are separated from the seed boll. For cotton gin waste, the treasure is its hidden potential to transform silver ions into silver nanoparticles and create a new hybrid material that could be used to add antimicrobial properties to consumer products, like aerogels, packaging, or composites.

An April 9, 2024 US Dept. of Agriculture (USDA) Agricultural Research Service (ARS) news release, which originated the news item, provides more detail, Note: Links have been removed,

Silver nanoparticles are highly sought-after products in the nanotechnology industry because of their antibacterial, antifungal, antiviral, electrical, and optical properties. These nanoparticles have an estimated global production of 500 tons per year and are widely applied to consumer goods such as textiles, coatings, paints, pigments, electronics, optics, and packaging.

In a study published in ACS Omega, researchers from the United States Department of Agriculture (USDA)’s Agricultural Research Service (ARS) revealed the ability of cotton gin waste to synthesize and generate silver nanoparticles in the presence of silver ions.

“Our method not only lets cotton gin waste act as chemical agents for producing silver nanoparticles, which makes it cost-effective and environmentally friendly but also enables embedding the nanoparticles within the cotton gin waste matrix,” said Sunghyun Nam, research engineer at ARS’s Cotton Chemistry and Utilization Research Unit in New Orleans. “By embedding them in the cotton gin waste, these materials acquire antimicrobial properties.”

Nam said the researchers used a simple heat treatment of cotton gin waste materials in water containing silver ions that produced silver nanoparticles without the need for additional chemical agents.

This finding is significant since making silver nanoparticles usually requires chemical agents which can be costly and pose environmental concerns. Embedding nanoparticles into a material can also be challenging.

Developing nanoparticle embedding technology is not new for Nam and her team. They previously developed washable antimicrobial wipes by using raw cotton fiber that produced silver nanoparticles inside the fiber. The embedded silver nanoparticles can continue to kill harmful bacteria wash after wash.

Large quantities of cotton gin waste are generated annually, and the cotton ginning industry is always seeking new sustainable processes that upcycle crop residue.

“Our research paves the way for new material applications of cotton gin waste that can protect against microbial contamination,” said Nam.

A provisional patent application on the self-embedding silver nanoparticle biomass waste compositions has recently been filed.

The Agricultural Research Service is the U.S. Department of Agriculture’s chief scientific in-house research agency. Daily, ARS focuses on solutions to agricultural problems affecting America. Each dollar invested in U.S. agricultural research results in $20 of economic impact.

Despite the date of the news release, this is a relatively old paper; here’s a link to and a citation,

Unveiling the Hidden Value of Cotton Gin Waste: Natural Synthesis and Hosting of Silver Nanoparticles by Sunghyun Nam*, Michael Easson, Jacobs H. Jordan, Zhongqi He, Hailin Zhang, Michael Santiago Cintrón, and SeChin Chang. ACS Omega 2023, 8, 34, 31281–31292 DOI: https://doi.org/10.1021/acsomega.3c03653 Publication Date: August 9, 2023 © 2023 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY-NC-ND 4.0.

As you can see from the Creative Commons licence, this paper is open access.

Neural (brain) implants and hype (long read)

There was a big splash a few weeks ago when it was announced that Neuralink’s (Elon Musk company) brain implant had been surgically inserted into its first human patient.

Getting approval

David Tuffley, senior lecturer in Applied Ethics & CyberSecurity at Griffith University (Australia), provides a good overview of the road Neuralink took to getting FDA (US Food and Drug Administration) approval for human clinical trials in his May 29, 2023 essay for The Conversation, Note: Links have been removed,

Since its founding in 2016, Elon Musk’s neurotechnology company Neuralink has had the ambitious mission to build a next-generation brain implant with at least 100 times more brain connections than devices currently approved by the US Food and Drug Administration (FDA).

The company has now reached a significant milestone, having received FDA approval to begin human trials. So what were the issues keeping the technology in the pre-clinical trial phase for as long as it was? And have these concerns been addressed?

Neuralink is making a Class III medical device known as a brain-computer interface (BCI). The device connects the brain to an external computer via a Bluetooth signal, enabling continuous communication back and forth.

The device itself is a coin-sized unit called a Link. It’s implanted within a small disk-shaped cutout in the skull using a precision surgical robot. The robot splices a thousand tiny threads from the Link to certain neurons in the brain. [emphasis mine] Each thread is about a quarter the diameter of a human hair.

The company says the device could enable precise control of prosthetic limbs, giving amputees natural motor skills. It could revolutionise treatment for conditions such as Parkinson’s disease, epilepsy and spinal cord injuries. It also shows some promise for potential treatment of obesity, autism, depression, schizophrenia and tinnitus.

Several other neurotechnology companies and researchers have already developed BCI technologies that have helped people with limited mobility regain movement and complete daily tasks.

In February 2021, Musk said Neuralink was working with the FDA to secure permission to start initial human trials later that year. But human trials didn’t commence in 2021.

Then, in March 2022, Neuralink made a further application to the FDA to establish its readiness to begin humans trials.

One year and three months later, on May 25 2023, Neuralink finally received FDA approval for its first human clinical trial. Given how hard Neuralink has pushed for permission to begin, we can assume it will begin very soon. [emphasis mine]

The approval has come less than six months after the US Office of the Inspector General launched an investigation into Neuralink over potential animal welfare violations. [emphasis mine]

In accessible language, Tuffley goes on to discuss the FDA’s specific technical issues with implants and how they were addressed in his May 29, 2023 essay.

More about how Neuralink’s implant works and some concerns

Canadian Broadcasting Corporation (CBC) journalist Andrew Chang offers an almost 13 minute video, “Neuralink brain chip’s first human patient. How does it work?” Chang is a little overenthused for my taste but he offers some good information about neural implants, along with informative graphics in his presentation.

So, Tuffley was right about Neuralink getting ready quickly for human clinical trials as you can guess from the title of Chang’s CBC video.

Jennifer Korn announced that recruitment had started in her September 20, 2023 article for CNN (Cable News Network), Note: Links have been removed,

Elon Musk’s controversial biotechnology startup Neuralink opened up recruitment for its first human clinical trial Tuesday, according to a company blog.

After receiving approval from an independent review board, Neuralink is set to begin offering brain implants to paralysis patients as part of the PRIME Study, the company said. PRIME, short for Precise Robotically Implanted Brain-Computer Interface, is being carried out to evaluate both the safety and functionality of the implant.

Trial patients will have a chip surgically placed in the part of the brain that controls the intention to move. The chip, installed by a robot, will then record and send brain signals to an app, with the initial goal being “to grant people the ability to control a computer cursor or keyboard using their thoughts alone,” the company wrote.

Those with quadriplegia [sometimes known as tetraplegia] due to cervical spinal cord injury or amyotrophic lateral sclerosis (ALS) may qualify for the six-year-long study – 18 months of at-home and clinic visits followed by follow-up visits over five years. Interested people can sign up in the patient registry on Neuralink’s website.

Musk has been working on Neuralink’s goal of using implants to connect the human brain to a computer for five years, but the company so far has only tested on animals. The company also faced scrutiny after a monkey died in project testing in 2022 as part of efforts to get the animal to play Pong, one of the first video games.

I mentioned three Reuters investigative journalists who were reporting on Neuralink’s animal abuse allegations (emphasized in Tuffley’s essay) in a July 7, 2023 posting, “Global dialogue on the ethics of neurotechnology on July 13, 2023 led by UNESCO.” Later that year, Neuralink was cleared by the US Department of Agriculture (see September 24,, 2023 article by Mahnoor Jehangir for BNN Breaking).

Plus, Neuralink was being investigated over more allegations according to a February 9, 2023 article by Rachel Levy for Reuters, this time regarding hazardous pathogens,

The U.S. Department of Transportation said on Thursday it is investigating Elon Musk’s brain-implant company Neuralink over the potentially illegal movement of hazardous pathogens.

A Department of Transportation spokesperson told Reuters about the probe after the Physicians Committee of Responsible Medicine (PCRM), an animal-welfare advocacy group,wrote to Secretary of Transportation Pete Buttigieg, opens new tab earlier on Thursday to alert it of records it obtained on the matter.

PCRM said it obtained emails and other documents that suggest unsafe packaging and movement of implants removed from the brains of monkeys. These implants may have carried infectious diseases in violation of federal law, PCRM said.

There’s an update about the hazardous materials in the next section. Spoiler alert, the company got fined.

Neuralink’s first human implant

A January 30, 2024 article (Associated Press with files from Reuters) on the Canadian Broadcasting Corporation’s (CBC) online news webspace heralded the latest about Neurlink’s human clinical trials,

The first human patient received an implant from Elon Musk’s computer-brain interface company Neuralink over the weekend, the billionaire says.

In a post Monday [January 29, 2024] on X, the platform formerly known as Twitter, Musk said that the patient received the implant the day prior and was “recovering well.” He added that “initial results show promising neuron spike detection.”

Spikes are activity by neurons, which the National Institutes of Health describe as cells that use electrical and chemical signals to send information around the brain and to the body.

The billionaire, who owns X and co-founded Neuralink, did not provide additional details about the patient.

When Neuralink announced in September [2023] that it would begin recruiting people, the company said it was searching for individuals with quadriplegia due to cervical spinal cord injury or amyotrophic lateral sclerosis, commonly known as ALS or Lou Gehrig’s disease.

Neuralink reposted Musk’s Monday [January 29, 2024] post on X, but did not publish any additional statements acknowledging the human implant. The company did not immediately respond to requests for comment from The Associated Press or Reuters on Tuesday [January 30, 2024].

In a separate Monday [January 29, 2024] post on X, Musk said that the first Neuralink product is called “Telepathy” — which, he said, will enable users to control their phones or computers “just by thinking.” He said initial users would be those who have lost use of their limbs.

The startup’s PRIME Study is a trial for its wireless brain-computer interface to evaluate the safety of the implant and surgical robot.

Now for the hazardous materials, January 30, 2024 article, Note: A link has been removed,

Earlier this month [January 2024], a Reuters investigation found that Neuralink was fined for violating U.S. Department of Transportation (DOT) rules regarding the movement of hazardous materials. During inspections of the company’s facilities in Texas and California in February 2023, DOT investigators found the company had failed to register itself as a transporter of hazardous material.

They also found improper packaging of hazardous waste, including the flammable liquid Xylene. Xylene can cause headaches, dizziness, confusion, loss of muscle co-ordination and even death, according to the U.S. Centers for Disease Control and Prevention.

The records do not say why Neuralink would need to transport hazardous materials or whether any harm resulted from the violations.

Skeptical thoughts about Elon Musk and Neuralink

Earlier this month (February 2024), the British Broadcasting Corporation (BBC) published an article by health reporters, Jim Reed and Joe McFadden, that highlights the history of brain implants, the possibilities, and notes some of Elon Musk’s more outrageous claims for Neuralink’s brain implants,

Elon Musk is no stranger to bold claims – from his plans to colonise Mars to his dreams of building transport links underneath our biggest cities. This week the world’s richest man said his Neuralink division had successfully implanted its first wireless brain chip into a human.

Is he right when he says this technology could – in the long term – save the human race itself?

Sticking electrodes into brain tissue is really nothing new.

In the 1960s and 70s electrical stimulation was used to trigger or suppress aggressive behaviour in cats. By the early 2000s monkeys were being trained to move a cursor around a computer screen using just their thoughts.

“It’s nothing novel, but implantable technology takes a long time to mature, and reach a stage where companies have all the pieces of the puzzle, and can really start to put them together,” says Anne Vanhoestenberghe, professor of active implantable medical devices, at King’s College London.

Neuralink is one of a growing number of companies and university departments attempting to refine and ultimately commercialise this technology. The focus, at least to start with, is on paralysis and the treatment of complex neurological conditions.

Reed and McFadden’s February 2024 BBC article describes a few of the other brain implant efforts, Note: Links have been removed,

One of its [Neuralink’s] main rivals, a start-up called Synchron backed by funding from investment firms controlled by Bill Gates and Jeff Bezos, has already implanted its stent-like device into 10 patients.

Back in December 2021, Philip O’Keefe, a 62-year old Australian who lives with a form of motor neurone disease, composed the first tweet using just his thoughts to control a cursor.

And researchers at Lausanne University in Switzerland have shown it is possible for a paralysed man to walk again by implanting multiple devices to bypass damage caused by a cycling accident.

In a research paper published this year, they demonstrated a signal could be beamed down from a device in his brain to a second device implanted at the base of his spine, which could then trigger his limbs to move.

Some people living with spinal injuries are sceptical about the sudden interest in this new kind of technology.

“These breakthroughs get announced time and time again and don’t seem to be getting any further along,” says Glyn Hayes, who was paralysed in a motorbike accident in 2017, and now runs public affairs for the Spinal Injuries Association.

If I could have anything back, it wouldn’t be the ability to walk. It would be putting more money into a way of removing nerve pain, for example, or ways to improve bowel, bladder and sexual function.” [emphasis mine]

Musk, however, is focused on something far more grand for Neuralink implants, from Reed and McFadden’s February 2024 BBC article, Note: A link has been removed,

But for Elon Musk, “solving” brain and spinal injuries is just the first step for Neuralink.

The longer-term goal is “human/AI symbiosis” [emphasis mine], something he describes as “species-level important”.

Musk himself has already talked about a future where his device could allow people to communicate with a phone or computer “faster than a speed typist or auctioneer”.

In the past, he has even said saving and replaying memories may be possible, although he recognised “this is sounding increasingly like a Black Mirror episode.”

One of the experts quoted in Reed and McFadden’s February 2024 BBC article asks a pointed question,

… “At the moment, I’m struggling to see an application that a consumer would benefit from, where they would take the risk of invasive surgery,” says Prof Vanhoestenberghe.

“You’ve got to ask yourself, would you risk brain surgery just to be able to order a pizza on your phone?”

Rae Hodge’s February 11, 2024 article about Elon Musk and his hyped up Neuralink implant for Salon is worth reading in its entirety but for those who don’t have the time or need a little persuading, here are a few excerpts, Note 1: This is a warning; Hodge provides more detail about the animal cruelty allegations; Note 2: Links have been removed,

Elon Musk’s controversial brain-computer interface (BCI) tech, Neuralink, has supposedly been implanted in its first recipient — and as much as I want to see progress for treatment of paralysis and neurodegenerative disease, I’m not celebrating. I bet the neuroscientists he reportedly drove out of the company aren’t either, especially not after seeing the gruesome torture of test monkeys and apparent cover-up that paved the way for this moment. 

All of which is an ethics horror show on its own. But the timing of Musk’s overhyped implant announcement gives it an additional insulting subtext. Football players are currently in a battle for their lives against concussion-based brain diseases that plague autopsy reports of former NFL players. And Musk’s boast of false hope came just two weeks before living players take the field in the biggest and most brutal game of the year. [2024 Super Bowl LVIII]

ESPN’s Kevin Seifert reports neuro-damage is up this year as “players suffered a total of 52 concussions from the start of training camp to the beginning of the regular season. The combined total of 213 preseason and regular season concussions was 14% higher than 2021 but within range of the three-year average from 2018 to 2020 (203).”

I’m a big fan of body-tech: pacemakers, 3D-printed hips and prosthetic limbs that allow you to wear your wedding ring again after 17 years. Same for brain chips. But BCI is the slow-moving front of body-tech development for good reason. The brain is too understudied. Consequences of the wrong move are dire. Overpromising marketable results on profit-driven timelines — on the backs of such a small community of researchers in a relatively new field — would be either idiotic or fiendish. 

Brown University’s research in the sector goes back to the 1990s. Since the emergence of a floodgate-opening 2002 study and the first implant in 2004 by med-tech company BrainGate, more promising results have inspired broader investment into careful research. But BrainGate’s clinical trials started back in 2009, and as noted by Business Insider’s Hilary Brueck, are expected to continue until 2038 — with only 15 participants who have devices installed. 

Anne Vanhoestenberghe is a professor of active implantable medical devices at King’s College London. In a recent release, she cautioned against the kind of hype peddled by Musk.

“Whilst there are a few other companies already using their devices in humans and the neuroscience community have made remarkable achievements with those devices, the potential benefits are still significantly limited by technology,” she said. “Developing and validating core technology for long term use in humans takes time and we need more investments to ensure we do the work that will underpin the next generation of BCIs.” 

Neuralink is a metal coin in your head that connects to something as flimsy as an app. And we’ve seen how Elon treats those. We’ve also seen corporate goons steal a veteran’s prosthetic legs — and companies turn brain surgeons and dentists into repo-men by having them yank anti-epilepsy chips out of people’s skulls, and dentures out of their mouths. 

“I think we have a chance with Neuralink to restore full-body functionality to someone who has a spinal cord injury,” Musk said at a 2023 tech summit, adding that the chip could possibly “make up for whatever lost capacity somebody has.”

Maybe BCI can. But only in the careful hands of scientists who don’t have Musk squawking “go faster!” over their shoulders. His greedy frustration with the speed of BCI science is telling, as is the animal cruelty it reportedly prompted.

There have been other examples of Musk’s grandiosity. Notably, David Lee expressed skepticism about hyperloop in his August 13, 2013 article for BBC news online

Is Elon Musk’s Hyperloop just a pipe dream?

Much like the pun in the headline, the bright idea of transporting people using some kind of vacuum-like tube is neither new nor imaginative.

There was Robert Goddard, considered the “father of modern rocket propulsion”, who claimed in 1909 that his vacuum system could suck passengers from Boston to New York at 1,200mph.

And then there were Soviet plans for an amphibious monorail  – mooted in 1934  – in which two long pods would start their journey attached to a metal track before flying off the end and slipping into the water like a two-fingered Kit Kat dropped into some tea.

So ever since inventor and entrepreneur Elon Musk hit the world’s media with his plans for the Hyperloop, a healthy dose of scepticism has been in the air.

“This is by no means a new idea,” says Rod Muttram, formerly of Bombardier Transportation and Railtrack.

“It has been previously suggested as a possible transatlantic transport system. The only novel feature I see is the proposal to put the tubes above existing roads.”

Here’s the latest I’ve found on hyperloop, from the Hyperloop Wikipedia entry,

As of 2024, some companies continued to pursue technology development under the hyperloop moniker, however, one of the biggest, well funded players, Hyperloop One, declared bankruptcy and ceased operations in 2023.[15]

Musk is impatient and impulsive as noted in a September 12, 2023 posting by Mike Masnick on Techdirt, Note: A link has been removed,

The Batshit Crazy Story Of The Day Elon Musk Decided To Personally Rip Servers Out Of A Sacramento Data Center

Back on Christmas Eve [December 24, 2022] of last year there were some reports that Elon Musk was in the process of shutting down Twitter’s Sacramento data center. In that article, a number of ex-Twitter employees were quoted about how much work it would be to do that cleanly, noting that there’s a ton of stuff hardcoded in Twitter code referring to that data center (hold that thought).

That same day, Elon tweeted out that he had “disconnected one of the more sensitive server racks.”

Masnick follows with a story of reckless behaviour from someone who should have known better.

Ethics of implants—where to look for more information

While Musk doesn’t use the term when he describes a “human/AI symbiosis” (presumably by way of a neural implant), he’s talking about a cyborg. Here’s a 2018 paper, which looks at some of the implications,

Do you want to be a cyborg? The moderating effect of ethics on neural implant acceptance by Eva Reinares-Lara, Cristina Olarte-Pascual, and Jorge Pelegrín-Borondo. Computers in Human Behavior Volume 85, August 2018, Pages 43-53 DOI: https://doi.org/10.1016/j.chb.2018.03.032

This paper is open access.

Getting back to Neuralink, I have two blog posts that discuss the company and the ethics of brain implants from way back in 2021.

First, there’s Jazzy Benes’ March 1, 2021 posting on the Santa Clara University’s Markkula Center for Applied Ethics blog. It stands out as it includes a discussion of the disabled community’s issues, Note: Links have been removed,

In the heart of Silicon Valley we are constantly enticed by the newest technological advances. With the big influencers Grimes [a Canadian musician and the mother of three children with Elon Musk] and Lil Uzi Vert publicly announcing their willingness to become experimental subjects for Elon Musk’s Neuralink brain implantation device, we are left wondering if future technology will actually give us “the knowledge of the Gods.” Is it part of the natural order for humans to become omniscient beings? Who will have access to the devices? What other ethical considerations must be discussed before releasing such technology to the public?

A significant issue that arises from developing technologies for the disabled community is the assumption that disabled persons desire the abilities of what some abled individuals may define as “normal.” Individuals with disabilities may object to technologies intended to make them fit an able-bodied norm. “Normal” is relative to each individual, and it could be potentially harmful to use a deficit view of disability, which means judging a disability as a deficiency. However, this is not to say that all disabled individuals will reject a technology that may enhance their abilities. Instead, I believe it is a consideration that must be recognized when developing technologies for the disabled community, and it can only be addressed through communication with disabled persons. As a result, I believe this is a conversation that must be had with the community for whom the technology is developed–disabled persons.

With technologies that aim to address disabilities, we walk a fine line between therapeutics and enhancement. Though not the first neural implant medical device, the Link may have been the first BCI system openly discussed for its potential transhumanism uses, such as “enhanced cognitive abilities, memory storage and retrieval, gaming, telepathy, and even symbiosis with machines.” …

Benes also discusses transhumanism, privacy issues, and consent issues. It’s a thoughtful reading experience.

Second is a July 9, 2021 posting by anonymous on the University of California at Berkeley School of Information blog which provides more insight into privacy and other issues associated with data collection (and introduced me to the concept of decisional interference),

As the development of microchips furthers and advances in neuroscience occur, the possibility for seamless brain-machine interfaces, where a device decodes inputs from the user’s brain to perform functions, becomes more of a reality. These various forms of these technologies already exist. However, technological advances have made implantable and portable devices possible. Imagine a future where humans don’t need to talk to each other, but rather can transmit their thoughts directly to another person. This idea is the eventual goal of Elon Musk, the founder of Neuralink. Currently, Neuralink is one of the main companies involved in the advancement of this type of technology. Analysis of the Neuralink’s technology and their overall mission statement provide an interesting insight into the future of this type of human-computer interface and the potential privacy and ethical concerns with this technology.

As this technology further develops, several privacy and ethical concerns come into question. To begin, using Solove’s Taxonomy as a privacy framework, many areas of potential harm are revealed. In the realm of information collection, there is much risk. Brain-computer interfaces, depending on where they are implanted, could have access to people’s most private thoughts and emotions. This information would need to be transmitted to another device for processing. The collection of this information by companies such as advertisers would represent a major breach of privacy. Additionally, there is risk to the user from information processing. These devices must work concurrently with other devices and often wirelessly. Given the widespread importance of cloud computing in much of today’s technology, offloading information from these devices to the cloud would be likely. Having the data stored in a database puts the user at the risk of secondary use if proper privacy policies are not implemented. The trove of information stored within the information collected from the brain is vast. These datasets could be combined with existing databases such as browsing history on Google to provide third parties with unimaginable context on individuals. Lastly, there is risk for information dissemination, more specifically, exposure. The information collected and processed by these devices would need to be stored digitally. Keeping such private information, even if anonymized, would be a huge potential for harm, as the contents of the information may in itself be re-identifiable to a specific individual. Lastly there is risk for invasions such as decisional interference. Brain-machine interfaces would not only be able to read information in the brain but also write information. This would allow the device to make potential emotional changes in its users, which be a major example of decisional interference. …

For the most recent Neuralink and brain implant ethics piece, there’s this February 14, 2024 essay on The Conversation, which, unusually, for this publication was solicited by the editors, Note: Links have been removed,

In January 2024, Musk announced that Neuralink implanted its first chip in a human subject’s brain. The Conversation reached out to two scholars at the University of Washington School of Medicine – Nancy Jecker, a bioethicst, and Andrew Ko, a neurosurgeon who implants brain chip devices – for their thoughts on the ethics of this new horizon in neuroscience.

Information about the implant, however, is scarce, aside from a brochure aimed at recruiting trial subjects. Neuralink did not register at ClinicalTrials.gov, as is customary, and required by some academic journals. [all emphases mine]

Some scientists are troubled by this lack of transparency. Sharing information about clinical trials is important because it helps other investigators learn about areas related to their research and can improve patient care. Academic journals can also be biased toward positive results, preventing researchers from learning from unsuccessful experiments.

Fellows at the Hastings Center, a bioethics think tank, have warned that Musk’s brand of “science by press release, while increasingly common, is not science. [emphases mine]” They advise against relying on someone with a huge financial stake in a research outcome to function as the sole source of information.

When scientific research is funded by government agencies or philanthropic groups, its aim is to promote the public good. Neuralink, on the other hand, embodies a private equity model [emphasis mine], which is becoming more common in science. Firms pooling funds from private investors to back science breakthroughs may strive to do good, but they also strive to maximize profits, which can conflict with patients’ best interests.

In 2022, the U.S. Department of Agriculture investigated animal cruelty at Neuralink, according to a Reuters report, after employees accused the company of rushing tests and botching procedures on test animals in a race for results. The agency’s inspection found no breaches, according to a letter from the USDA secretary to lawmakers, which Reuters reviewed. However, the secretary did note an “adverse surgical event” in 2019 that Neuralink had self-reported.

In a separate incident also reported by Reuters, the Department of Transportation fined Neuralink for violating rules about transporting hazardous materials, including a flammable liquid.

…the possibility that the device could be increasingly shown to be helpful for people with disabilities, but become unavailable due to loss of research funding. For patients whose access to a device is tied to a research study, the prospect of losing access after the study ends can be devastating. [emphasis mine] This raises thorny questions about whether it is ever ethical to provide early access to breakthrough medical interventions prior to their receiving full FDA approval.

Not registering a clinical trial would seem to suggest there won’t be much oversight. As for Musk’s “science by press release” activities, I hope those will be treated with more skepticism by mainstream media although that seems unlikely given the current situation with journalism (more about that in a future post).

As for the issues associated with private equity models for science research and the problem of losing access to devices after a clinical trial is ended, my April 5, 2022 posting, “Going blind when your neural implant company flirts with bankruptcy (long read)” offers some cautionary tales, in addition to being the most comprehensive piece I’ve published on ethics and brain implants.

My July 17, 2023 posting, “Unveiling the Neurotechnology Landscape: Scientific Advancements, Innovations and Major Trends—a UNESCO report” offers a brief overview of the international scene.

Prioritizing ethical & social considerations in emerging technologies—$16M in US National Science Foundation funding

I haven’t seen this much interest in the ethics and social impacts of emerging technologies in years. It seems that the latest AI (artificial intelligence) panic has stimulated interest not only in regulation but ethics too.

The latest information I have on this topic comes from a January 9, 2024 US National Science Foundation (NSF) news release (also received via email),

NSF and philanthropic partners announce $16 million in funding to prioritize ethical and social considerations in emerging technologies

ReDDDoT is a collaboration with five philanthropic partners and crosses
all disciplines of science and engineering_

The U.S. National Science Foundation today launched a new $16 million
program in collaboration with five philanthropic partners that seeks to
ensure ethical, legal, community and societal considerations are
embedded in the lifecycle of technology’s creation and use. The
Responsible Design, Development and Deployment of Technologies (ReDDDoT)
program aims to help create technologies that promote the public’s
wellbeing and mitigate potential harms.

“The design, development and deployment of technologies have broad
impacts on society,” said NSF Director Sethuraman Panchanathan. “As
discoveries and innovations are translated to practice, it is essential
that we engage and enable diverse communities to participate in this
work. NSF and its philanthropic partners share a strong commitment to
creating a comprehensive approach for co-design through soliciting
community input, incorporating community values and engaging a broad
array of academic and professional voices across the lifecycle of
technology creation and use.”

The ReDDDoT program invites proposals from multidisciplinary,
multi-sector teams that examine and demonstrate the principles,
methodologies and impacts associated with responsible design,
development and deployment of technologies, especially those specified
in the “CHIPS and Science Act of 2022.” In addition to NSF, the
program is funded and supported by the Ford Foundation, the Patrick J.
McGovern Foundation, Pivotal Ventures, Siegel Family Endowment and the
Eric and Wendy Schmidt Fund for Strategic Innovation.

“In recognition of the role responsible technologists can play to
advance human progress, and the danger unaccountable technology poses to
social justice, the ReDDDoT program serves as both a collaboration and a
covenant between philanthropy and government to center public interest
technology into the future of progress,” said Darren Walker, president
of the Ford Foundation. “This $16 million initiative will cultivate
expertise from public interest technologists across sectors who are
rooted in community and grounded by the belief that innovation, equity
and ethics must equally be the catalysts for technological progress.”

The broad goals of ReDDDoT include:  

*Stimulating activity and filling gaps in research, innovation and capacity building in the responsible design, development, and deployment of technologies.
* Creating broad and inclusive communities of interest that bring
together key stakeholders to better inform practices for the design,
development, and deployment of technologies.
* Educating and training the science, technology, engineering, and
mathematics workforce on approaches to responsible design,
development, and deployment of technologies. 
* Accelerating pathways to societal and economic benefits while
developing strategies to avoid or mitigate societal and economic harms.
* Empowering communities, including economically disadvantaged and
marginalized populations, to participate in all stages of technology
development, including the earliest stages of ideation and design.

Phase 1 of the program solicits proposals for Workshops, Planning
Grants, or the creation of Translational Research Coordination Networks,
while Phase 2 solicits full project proposals. The initial areas of
focus for 2024 include artificial intelligence, biotechnology or natural
and anthropogenic disaster prevention or mitigation. Future iterations
of the program may consider other key technology focus areas enumerated
in the CHIPS and Science Act.

For more information about ReDDDoT, visit the program website or register for an informational webinar on Feb. 9, 2024, at 2 p.m. ET.

Statements from NSF’s Partners

“The core belief at the heart of ReDDDoT – that technology should be
shaped by ethical, legal, and societal considerations as well as
community values – also drives the work of the Patrick J. McGovern
Foundation to build a human-centered digital future for all. We’re
pleased to support this partnership, committed to advancing the
development of AI, biotechnology, and climate technologies that advance
equity, sustainability, and justice.” – Vilas Dhar, President, Patrick
J. McGovern Foundation

“From generative AI to quantum computing, the pace of technology
development is only accelerating. Too often, technological advances are
not accompanied by discussion and design that considers negative impacts
or unrealized potential. We’re excited to support ReDDDoT as an
opportunity to uplift new and often forgotten perspectives that
critically examine technology’s impact on civic life, and advance Siegel
Family Endowment’s vision of technological change that includes and
improves the lives of all people.” – Katy Knight, President and
Executive Director of Siegel Family Endowment

Only eight months ago, another big NSF funding project was announced but this time focused on AI and promoting trust, from a May 4, 2023 University of Maryland (UMD) news release (also on EurekAlert), Note: A link has been removed,

The University of Maryland has been chosen to lead a multi-institutional effort supported by the National Science Foundation (NSF) that will develop new artificial intelligence (AI) technologies designed to promote trust and mitigate risks, while simultaneously empowering and educating the public.

The NSF Institute for Trustworthy AI in Law & Society (TRAILS) announced on May 4, 2023, unites specialists in AI and machine learning with social scientists, legal scholars, educators and public policy experts. The multidisciplinary team will work with impacted communities, private industry and the federal government to determine what trust in AI looks like, how to develop technical solutions for AI that can be trusted, and which policy models best create and sustain trust.

Funded by a $20 million award from NSF, the new institute is expected to transform the practice of AI from one driven primarily by technological innovation to one that is driven by ethics, human rights, and input and feedback from communities whose voices have previously been marginalized.

“As artificial intelligence continues to grow exponentially, we must embrace its potential for helping to solve the grand challenges of our time, as well as ensure that it is used both ethically and responsibly,” said UMD President Darryll J. Pines. “With strong federal support, this new institute will lead in defining the science and innovation needed to harness the power of AI for the benefit of the public good and all humankind.”

In addition to UMD, TRAILS will include faculty members from George Washington University (GW) and Morgan State University, with more support coming from Cornell University, the National Institute of Standards and Technology (NIST), and private sector organizations like the DataedX Group, Arthur AI, Checkstep, FinRegLab and Techstars.

At the heart of establishing the new institute is the consensus that AI is currently at a crossroads. AI-infused systems have great potential to enhance human capacity, increase productivity, catalyze innovation, and mitigate complex problems, but today’s systems are developed and deployed in a process that is opaque and insular to the public, and therefore, often untrustworthy to those affected by the technology.

“We’ve structured our research goals to educate, learn from, recruit, retain and support communities whose voices are often not recognized in mainstream AI development,” said Hal Daumé III, a UMD professor of computer science who is lead principal investigator of the NSF award and will serve as the director of TRAILS.

Inappropriate trust in AI can result in many negative outcomes, Daumé said. People often “overtrust” AI systems to do things they’re fundamentally incapable of. This can lead to people or organizations giving up their own power to systems that are not acting in their best interest. At the same time, people can also “undertrust” AI systems, leading them to avoid using systems that could ultimately help them.

Given these conditions—and the fact that AI is increasingly being deployed to mediate society’s online communications, determine health care options, and offer guidelines in the criminal justice system—it has become urgent to ensure that people’s trust in AI systems matches those same systems’ level of trustworthiness.

TRAILS has identified four key research thrusts to promote the development of AI systems that can earn the public’s trust through broader participation in the AI ecosystem.

The first, known as participatory AI, advocates involving human stakeholders in the development, deployment and use of these systems. It aims to create technology in a way that aligns with the values and interests of diverse groups of people, rather than being controlled by a few experts or solely driven by profit.

Leading the efforts in participatory AI is Katie Shilton, an associate professor in UMD’s College of Information Studies who specializes in ethics and sociotechnical systems. Tom Goldstein, a UMD associate professor of computer science, will lead the institute’s second research thrust, developing advanced machine learning algorithms that reflect the values and interests of the relevant stakeholders.

Daumé, Shilton and Goldstein all have appointments in the University of Maryland Institute for Advanced Computer Studies, which is providing administrative and technical support for TRAILS.

David Broniatowski, an associate professor of engineering management and systems engineering at GW, will lead the institute’s third research thrust of evaluating how people make sense of the AI systems that are developed, and the degree to which their levels of reliability, fairness, transparency and accountability will lead to appropriate levels of trust. Susan Ariel Aaronson, a research professor of international affairs at GW, will use her expertise in data-driven change and international data governance to lead the institute’s fourth thrust of participatory governance and trust.

Virginia Byrne, an assistant professor of higher education and student affairs at Morgan State, will lead community-driven projects related to the interplay between AI and education. According to Daumé, the TRAILS team will rely heavily on Morgan State’s leadership—as Maryland’s preeminent public urban research university—in conducting rigorous, participatory community-based research with broad societal impacts.

Additional academic support will come from Valerie Reyna, a professor of human development at Cornell, who will use her expertise in human judgment and cognition to advance efforts focused on how people interpret their use of AI.

Federal officials at NIST will collaborate with TRAILS in the development of meaningful measures, benchmarks, test beds and certification methods—particularly as they apply to important topics essential to trust and trustworthiness such as safety, fairness, privacy, transparency, explainability, accountability, accuracy and reliability.

“The ability to measure AI system trustworthiness and its impacts on individuals, communities and society is limited. TRAILS can help advance our understanding of the foundations of trustworthy AI, ethical and societal considerations of AI, and how to build systems that are trusted by the people who use and are affected by them,” said Under Secretary of Commerce for Standards and Technology and NIST Director Laurie E. Locascio.

Today’s announcement [May 4, 2023] is the latest in a series of federal grants establishing a cohort of National Artificial Intelligence Research Institutes. This recent investment in seven new AI institutes, totaling $140 million, follows two previous rounds of awards.

“Maryland is at the forefront of our nation’s scientific innovation thanks to our talented workforce, top-tier universities, and federal partners,” said U.S. Sen. Chris Van Hollen (D-Md.). “This National Science Foundation award for the University of Maryland—in coordination with other Maryland-based research institutions including Morgan State University and NIST—will promote ethical and responsible AI development, with the goal of helping us harness the benefits of this powerful emerging technology while limiting the potential risks it poses. This investment entrusts Maryland with a critical priority for our shared future, recognizing the unparalleled ingenuity and world-class reputation of our institutions.” 

The NSF, in collaboration with government agencies and private sector leaders, has now invested close to half a billion dollars in the AI institutes ecosystem—an investment that expands a collaborative AI research network into almost every U.S. state.

“The National AI Research Institutes are a critical component of our nation’s AI innovation, infrastructure, technology, education and partnerships ecosystem,” said NSF Director Sethuraman Panchanathan. “[They] are driving discoveries that will ensure our country is at the forefront of the global AI revolution.”

As noted in the UMD news release, this funding is part of a ‘bundle’, here’s more from the May 4, 2023 US NSF news release announcing the full $ 140 million funding program, Note: Links have been removed,

The U.S. National Science Foundation, in collaboration with other federal agencies, higher education institutions and other stakeholders, today announced a $140 million investment to establish seven new National Artificial Intelligence Research Institutes. The announcement is part of a broader effort across the federal government to advance a cohesive approach to AI-related opportunities and risks.

The new AI Institutes will advance foundational AI research that promotes ethical and trustworthy AI systems and technologies, develop novel approaches to cybersecurity, contribute to innovative solutions to climate change, expand the understanding of the brain, and leverage AI capabilities to enhance education and public health. The institutes will support the development of a diverse AI workforce in the U.S. and help address the risks and potential harms posed by AI.  This investment means  NSF and its funding partners have now invested close to half a billion dollars in the AI Institutes research network, which reaches almost every U.S. state.

“The National AI Research Institutes are a critical component of our nation’s AI innovation, infrastructure, technology, education and partnerships ecosystem,” said NSF Director Sethuraman Panchanathan. “These institutes are driving discoveries that will ensure our country is at the forefront of the global AI revolution.”

“These strategic federal investments will advance American AI infrastructure and innovation, so that AI can help tackle some of the biggest challenges we face, from climate change to health. Importantly, the growing network of National AI Research Institutes will promote responsible innovation that safeguards people’s safety and rights,” said White House Office of Science and Technology Policy Director Arati Prabhakar.

The new AI Institutes are interdisciplinary collaborations among top AI researchers and are supported by co-funding from the U.S. Department of Commerce’s National Institutes of Standards and Technology (NIST); U.S. Department of Homeland Security’s Science and Technology Directorate (DHS S&T); U.S. Department of Agriculture’s National Institute of Food and Agriculture (USDA-NIFA); U.S. Department of Education’s Institute of Education Sciences (ED-IES); U.S. Department of Defense’s Office of the Undersecretary of Defense for Research and Engineering (DoD OUSD R&E); and IBM Corporation (IBM).

“Foundational research in AI and machine learning has never been more critical to the understanding, creation and deployment of AI-powered systems that deliver transformative and trustworthy solutions across our society,” said NSF Assistant Director for Computer and Information Science and Engineering Margaret Martonosi. “These recent awards, as well as our AI Institutes ecosystem as a whole, represent our active efforts in addressing national economic and societal priorities that hinge on our nation’s AI capability and leadership.”

The new AI Institutes focus on six research themes:

Trustworthy AI

NSF Institute for Trustworthy AI in Law & Society (TRAILS)

Led by the University of Maryland, TRAILS aims to transform the practice of AI from one driven primarily by technological innovation to one driven with attention to ethics, human rights and support for communities whose voices have been marginalized into mainstream AI. TRAILS will be the first institute of its kind to integrate participatory design, technology, and governance of AI systems and technologies and will focus on investigating what trust in AI looks like, whether current technical solutions for AI can be trusted, and which policy models can effectively sustain AI trustworthiness. TRAILS is funded by a partnership between NSF and NIST.

Intelligent Agents for Next-Generation Cybersecurity

AI Institute for Agent-based Cyber Threat Intelligence and Operation (ACTION)

Led by the University of California, Santa Barbara, this institute will develop novel approaches that leverage AI to anticipate and take corrective actions against cyberthreats that target the security and privacy of computer networks and their users. The team of researchers will work with experts in security operations to develop a revolutionary approach to cybersecurity, in which AI-enabled intelligent security agents cooperate with humans across the cyberdefense life cycle to jointly improve the resilience of security of computer systems over time. ACTION is funded by a partnership between NSF, DHS S&T, and IBM.

Climate Smart Agriculture and Forestry

AI Institute for Climate-Land Interactions, Mitigation, Adaptation, Tradeoffs and Economy (AI-CLIMATE)

Led by the University of Minnesota Twin Cities, this institute aims to advance foundational AI by incorporating knowledge from agriculture and forestry sciences and leveraging these unique, new AI methods to curb climate effects while lifting rural economies. By creating a new scientific discipline and innovation ecosystem intersecting AI and climate-smart agriculture and forestry, our researchers and practitioners will discover and invent compelling AI-powered knowledge and solutions. Examples include AI-enhanced estimation methods of greenhouse gases and specialized field-to-market decision support tools. A key goal is to lower the cost of and improve accounting for carbon in farms and forests to empower carbon markets and inform decision making. The institute will also expand and diversify rural and urban AI workforces. AI-CLIMATE is funded by USDA-NIFA.

Neural and Cognitive Foundations of Artificial Intelligence

AI Institute for Artificial and Natural Intelligence (ARNI)

Led by Columbia University, this institute will draw together top researchers across the country to focus on a national priority: connecting the major progress made in AI systems to the revolution in our understanding of the brain. ARNI will meet the urgent need for new paradigms of interdisciplinary research between neuroscience, cognitive science and AI. This will accelerate progress in all three fields and broaden the transformative impact on society in the next decade. ARNI is funded by a partnership between NSF and DoD OUSD R&E.

AI for Decision Making

AI Institute for Societal Decision Making (AI-SDM)

Led by Carnegie Mellon University, this institute seeks to create human-centric AI for decision making to bolster effective response in uncertain, dynamic and resource-constrained scenarios like disaster management and public health. By bringing together an interdisciplinary team of AI and social science researchers, AI-SDM will enable emergency managers, public health officials, first responders, community workers and the public to make decisions that are data driven, robust, agile, resource efficient and trustworthy. The vision of the institute will be realized via development of AI theory and methods, translational research, training and outreach, enabled by partnerships with diverse universities, government organizations, corporate partners, community colleges, public libraries and high schools.

AI-Augmented Learning to Expand Education Opportunities and Improve Outcomes

AI Institute for Inclusive Intelligent Technologies for Education (INVITE)

Led by the University of Illinois Urbana-Champaign, this institute seeks to fundamentally reframe how educational technologies interact with learners by developing AI tools and approaches to support three crucial noncognitive skills known to underlie effective learning: persistence, academic resilience and collaboration. The institute’s use-inspired research will focus on how children communicate STEM content, how they learn to persist through challenging work, and how teachers support and promote noncognitive skill development. The resultant AI-based tools will be integrated into classrooms to empower teachers to support learners in more developmentally appropriate ways.

AI Institute for Exceptional Education (AI4ExceptionalEd)

Led by the University at Buffalo, this institute will work toward universal speech and language screening for children. The framework, the AI screener, will analyze video and audio streams of children during classroom interactions and assess the need for evidence-based interventions tailored to individual needs of students. The institute will serve children in need of ability-based speech and language services, advance foundational AI technologies and enhance understanding of childhood speech and language development. The AI Institute for Exceptional Education was previously announced in January 2023. The INVITE and AI4ExceptionalEd institutes are funded by a partnership between NSF and ED-IES.

Statements from NSF’s Federal Government Funding Partners

“Increasing AI system trustworthiness while reducing its risks will be key to unleashing AI’s potential benefits and ensuring our shared societal values,” said Under Secretary of Commerce for Standards and Technology and NIST Director Laurie E. Locascio. “Today, the ability to measure AI system trustworthiness and its impacts on individuals, communities and society is limited. TRAILS can help advance our understanding of the foundations of trustworthy AI, ethical and societal considerations of AI, and how to build systems that are trusted by the people who use and are affected by them.”

“The ACTION Institute will help us better assess the opportunities and risks of rapidly evolving AI technology and its impact on DHS missions,” said Dimitri Kusnezov, DHS under secretary for science and technology. “This group of researchers and their ambition to push the limits of fundamental AI and apply new insights represents a significant investment in cybersecurity defense. These partnerships allow us to collectively remain on the forefront of leading-edge research for AI technologies.”

“In the tradition of USDA National Institute of Food and Agriculture investments, this new institute leverages the scientific power of U.S. land-grant universities informed by close partnership with farmers, producers, educators and innovators to address the grand challenge of rising greenhouse gas concentrations and associated climate change,” said Acting NIFA Director Dionne Toombs. “This innovative center will address the urgent need to counter climate-related threats, lower greenhouse gas emissions, grow the American workforce and increase new rural opportunities.”

“The leading-edge in AI research inevitably draws from our, so far, limited understanding of human cognition. This AI Institute seeks to unify the fields of AI and neuroscience to bring advanced designs and approaches to more capable and trustworthy AI, while also providing better understanding of the human brain,” said Bindu Nair, director, Basic Research Office, Office of the Undersecretary of Defense for Research and Engineering. “We are proud to partner with NSF in this critical field of research, as continued advancement in these areas holds the potential for further and significant benefits to national security, the economy and improvements in quality of life.”

“We are excited to partner with NSF on these two AI institutes,” said IES Director Mark Schneider. “We hope that they will provide valuable insights into how to tap modern technologies to improve the education sciences — but more importantly we hope that they will lead to better student outcomes and identify ways to free up the time of teachers to deliver more informed individualized instruction for the students they care so much about.” 

Learn more about the NSF AI Institutes by visiting nsf.gov.

Two things I noticed, (1) No mention of including ethics training or concepts in science and technology education and (2) No mention of integrating ethics and social issues into any of the AI Institutes. So, it seems that ‘Responsible Design, Development and Deployment of Technologies (ReDDDoT)’ occupies its own fiefdom.

Some sobering thoughts

Things can go terribly wrong with new technology as seen in the British television hit series, Mr. Bates vs. The Post Office (based on a true story) , from a January 9, 2024 posting by Ani Blundel for tellyvisions.org,

… what is this show that’s caused the entire country to rise up as one to defend the rights of the lowly sub-postal worker? Known as the “British Post Office scandal,” the incidents first began in 1999 when the U.K. postal system began to switch to digital systems, using the Horizon Accounting system to track the monies brought in. However, the IT system was faulty from the start, and rather than blame the technology, the British government accused, arrested, persecuted, and convicted over 700 postal workers of fraud and theft. This continued through 2015 when the glitch was finally recognized, and in 2019, the convictions were ruled to be a miscarriage of justice.

Here’s the series synopsis:

The drama tells the story of one of the greatest miscarriages of justice in British legal history. Hundreds of innocent sub-postmasters and postmistresses were wrongly accused of theft, fraud, and false accounting due to a defective IT system. Many of the wronged workers were prosecuted, some of whom were imprisoned for crimes they never committed, and their lives were irreparably ruined by the scandal. Following the landmark Court of Appeal decision to overturn their criminal convictions, dozens of former sub-postmasters and postmistresses have been exonerated on all counts as they battled to finally clear their names. They fought for over ten years, finally proving their innocence and sealing a resounding victory, but all involved believe the fight is not over yet, not by a long way.

Here’s a video trailer for ‘Mr. Bates vs. The Post Office,

More from Blundel’s January 9, 2024 posting, Note: A link has been removed,

The outcry from the general public against the government’s bureaucratic mismanagement and abuse of employees has been loud and sustained enough that Prime Minister Rishi Sunak had to come out with a statement condemning what happened back during the 2009 incident. Further, the current Justice Secretary, Alex Chalk, is now trying to figure out the fastest way to exonerate the hundreds of sub-post managers and sub-postmistresses who were wrongfully convicted back then and if there are steps to be taken to punish the post office a decade later.

It’s a horrifying story and the worst I’ve seen so far but, sadly, it’s not the only one of its kind.

Too often people’s concerns and worries about new technology are dismissed or trivialized. Somehow, all the work done to establish ethical standards and develop trust seems to be used as a kind of sop to the concerns rather than being integrated into the implementation of life-altering technologies.

Nano 2020: a US education initiative

The US Department of Agriculture has a very interesting funding opportunity, Higher Education Challenge (HEC) Grants Program, as evidenced by the Nano 2020 virtual reality (VR) classroom initiative. Before launching into the specifics of the Nano 2020 project, here’s a description of the funding program,

Projects supported by the Higher Education Challenge Grants Program will: (1) address a state, regional, national, or international educational need; (2) involve a creative or non-traditional approach toward addressing that need that can serve as a model to others; (3) encourage and facilitate better working relationships in the university science and education community, as well as between universities and the private sector, to enhance program quality and supplement available resources; and (4) result in benefits that will likely transcend the project duration and USDA support.

A February 3, 2020 University of Arizona news release by Stacy Pigott (also on EurekAlert but published February 7, 2020) announced a VR classroom where students will be able to interact with nanoscale data gained from agricultural sciences and the life sciences,

Sometimes the smallest of things lead to the biggest ideas. Case in point: Nano 2020, a University of Arizona-led initiative to develop curriculum and technology focused on educating students in the rapidly expanding field of nanotechnology.

The five-year, multi-university project recently met its goal of creating globally relevant and implementable curricula and instructional technologies, to include a virtual reality classroom, that enhance the capacity of educators to teach students about innovative nanotechnology applications in agriculture and the life sciences.

Here’s a video from the University of Arizona’s project proponents which illustrates their classroom,

For those who prefer text or like to have it as a backup, here’s the rest of the news release explaining the project,

Visualizing What is Too Small to be Seen

Nanotechnology involves particles and devices developed and used at the scale of 100 nanometers or less – to put that in perspective, the average diameter of a human hair is 80,000 nanometers. The extremely small scale can make comprehension challenging when it comes to learning about things that cannot be seen with the naked eye.

That’s where the Nano 2020 virtual reality classroom comes in. In a custom-developed VR classroom complete with a laboratory, nanoscale objects come to life for students thanks to the power of science data visualization.

Within the VR environment, students can interact with objects of nanoscale proportions – pick them up, turn them around and examine every nuance of things that would otherwise be too small to see. Students can also interact with their instructor or their peers. The Nano 2020 classroom allows for multi-player functionality, giving educators and students the opportunity to connect in a VR laboratory in real time, no matter where they are in the world.

“The virtual reality technology brings to life this complex content in a way that is oddly simple,” said Matt Mars, associate professor of agricultural leadership and innovation education in the College of Agriculture and Life Sciences and co-director of the Nano 2020 grant. “Imagine if you can take a student and they see a nanometer from a distance, and then they’re able to approach it and see how small it is by actually being in it. It’s mind-blowing, but in a way that students will be like, ‘Oh wow, that is really cool!'”

The technology was developed by Tech Core, a group of student programmers and developers led by director Ash Black in the Eller College of Management.

“The thing that I was the most fascinated with from the beginning was playing with a sense of scale,” said Black, a lifelong technologist and mentor-in-residence at the McGuire Center for Entrepreneurship. “What really intrigued me about virtual reality is that it is a tool where scale is elastic – you can dial it up and dial it down. Obviously, with nanotechnology, you’re dealing with very, very small things that nobody has seen yet, so it seemed like a perfect use of virtual reality.”

Black and Tech Core students including Robert Johnson, Hazza Alkaabi, Matthew Romero, Devon Oberdan, Brandon Erickson and Tim Lukau turned science data into an object, the object into an image, and the image into a 3D rendering that is functional in the VR environment they built.

“I think that being able to interact with objects of nanoscale data in this environment will result in a lot of light bulbs going off in the students’ minds. I think they’ll get it,” Black said. “To be able to experience something that is abstract – like, what does a carbon atom look like – well, if you can actually look at it, that’s suddenly a whole lot of context.”

The VR classroom complements the Nano 2020 curriculum, which globally expands the opportunities for nanotechnology education within the fields of agriculture and the life sciences.

Teaching the Workforce of the Future

“There have been great advances to the use of nanotechnology in the health sciences, but many more opportunities for innovation in this area still exist in the agriculture fields. The idea is to be able to advance these opportunities for innovation by providing some educational tools,” said Randy Burd, who was a nutritional sciences professor at the University of Arizona when he started the Nano 2020 project with funding from a National Institute of Food and Agriculture Higher Education Challenge grant through the United States Department of Agriculture. “It not only will give students the basics of the understanding of the applications, but will give them the innovative thought processes to think of new creations. That’s the real key.”

Unknown Object

The goal of the Nano 2020 team, which includes faculty from the University of Arizona, Northern Arizona University and Johns Hopkins University, was to create an online suite of undergraduate courses that was not university-specific, but could be accessed and added to by educators to reach students around the world.

To that end, the team built modular courses in nanotechnology subjects such as glycobiology, optical microscopy and histology, nanomicroscopy techniques, nutritional genomics, applications of magnetic nanotechnology, and design, innovation, and entrepreneurship, to name a few. An online library will be created to facilitate the ongoing expansion of the open-source curricula, which will be disseminated through novel technologies such as the virtual reality classroom.

“It isn’t practical to think that other universities and colleges are just going to be able to launch new courses, because they still need people to teach those courses,” Mars said. “So we created a robust and flexible set of module-based course packages that include exercises, lectures, videos, power points, tools. Instructors will be able to pull out components and integrate them into what already exists to continue to move toward a more comprehensive offering in nanotechnology education.”

According to Mars, the highly adaptable nature of the curriculum and the ability to deliver it in various ways were key components of the Nano 2020 project.

“We approach the project with a strong entrepreneurial mindset and heavy emphasis on innovation. We wanted it to be broadly defined and flexible in structure, so that other institutions access and model the curricula, see its foundation, and adapt that to what their needs were to begin to disseminate the notion of nanotechnology as an underdeveloped but really important field within the larger landscape of agriculture and life sciences,” Mars said. “We wanted to also provide an overlay to the scientific and technological components that would be about adoption in human application, and we approached that through an innovation and entrepreneurial leadership lens.”

Portions of the Nano 2020 curriculum are currently being offered as electives in a certificate program through the Department of Agriculture Education, Technology and Innovation at the University of Arizona. As it becomes more widely disseminated through the higher education community at large, researchers expect the curriculum and VR classroom technology to transcend the boundaries of discipline, institution and geography.

“An online open platform will exist where people can download components and courses, and all of it is framed by the technology, so that these experiences and research can be shared over this virtual reality component,” Burd said. “It’s technologically distinct from what exists now.”

“The idea is that it’s not just curriculum, but it’s the delivery of that curriculum, and the delivery of that curriculum in various ways,” Mars said. “There’s a relatability that comes with the virtual reality that I think is really cool. It allows students to relate to something as abstract as a nanometer, and that is what is really exciting.”

As best I can determine, this VR Nano 2020 classroom is not yet ready for a wide release and, for now, is being offered exclusively at the University of Arizona.

The CRISPR yogurt story and a hornless cattle update

Clustered regularly interspaced short palindromic repeats (CRISPR) does not and never has made much sense to me. I understand each word individually it’s just that I’ve never thought they made much sense strung together that way. It’s taken years but I’ve finally found out what the words (when strung together that way) mean and the origins for the phrase. Hint: it’s all about the phages.

Apparently, it all started with yogurt as Cynthia Graber and Nicola Twilley of Gastropod discuss on their podcast, “4 CRISPR experts on how gene editing is changing the future of food.” During the course of the podcast they explain the ‘phraseology’ issue, mention hornless cattle (I have an update to the information in the podcast later in this posting), and so much more.

CRISPR started with yogurt

You’ll find the podcast (almost 50 minutes long) here on an Oct. 11, 2019 posting on the Genetic Literacy Project. If you need a little more encouragement, here’s how the podcast is described,

To understand how CRISPR will transform our food, we begin our episode at Dupont’s yoghurt culture facility in Madison, Wisconsin. Senior scientist Dennis Romero tells us the story of CRISPR’s accidental discovery—and its undercover but ubiquitous presence in the dairy aisles today.

Jennifer Kuzma and Yiping Qi help us understand the technology’s potential, both good and bad, as well as how it might be regulated and labeled. And Joyce Van Eck, a plant geneticist at the Boyce Thompson Institute in Ithaca, New York, tells us the story of how she is using CRISPR, combined with her understanding of tomato genetics, to fast-track the domestication of one of the Americas’ most delicious orphan crops [groundcherries].

I featured Van Eck’s work with groundcherries last year in a November 28, 2018 posting and I don’t think she’s published any new work about the fruit since. As for Kuzma’s point that there should be more transparency where genetically modified food is concerned, Canadian consumers were surprised (shocked) in 2017 to find out that genetically modified Atlantic salmon had been introduced into the food market without any notification (my September 13, 2017 posting; scroll down to the Fish subheading; Note: The WordPress ‘updated version from Hell’ has affected some of the formatting on the page).

The earliest article on CRISPR and yogurt that I’ve found is a January 1, 2015 article by Kerry Grens for The Scientist,

Two years ago, a genome-editing tool referred to as CRISPR (clustered regularly interspaced short palindromic repeats) burst onto the scene and swept through laboratories faster than you can say “adaptive immunity.” Bacteria and archaea evolved CRISPR eons before clever researchers harnessed the system to make very precise changes to pretty much any sequence in just about any genome.

But life scientists weren’t the first to get hip to CRISPR’s potential. For nearly a decade, cheese and yogurt makers have been relying on CRISPR to produce starter cultures that are better able to fend off bacteriophage attacks. “It’s a very efficient way to get rid of viruses for bacteria,” says Martin Kullen, the global R&D technology leader of Health and Protection at DuPont Nutrition & Health. “CRISPR’s been an important part of our solution to avoid food waste.”

Phage infection of starter cultures is a widespread and significant problem in the dairy-product business, one that’s been around as long as people have been making cheese. Patrick Derkx, senior director of innovation at Denmark-based Chr. Hansen, one of the world’s largest culture suppliers, estimates that the quality of about two percent of cheese production worldwide suffers from phage attacks. Infection can also slow the acidification of milk starter cultures, thereby reducing creameries’ capacity by up to about 10 percent, Derkx estimates.
In the early 2000s, Philippe Horvath and Rodolphe Barrangou of Danisco (later acquired by DuPont) and their colleagues were first introduced to CRISPR while sequencing Streptococcus thermophilus, a workhorse of yogurt and cheese production. Initially, says Barrangou, they had no idea of the purpose of the CRISPR sequences. But as his group sequenced different strains of the bacteria, they began to realize that CRISPR might be related to phage infection and subsequent immune defense. “That was an eye-opening moment when we first thought of the link between CRISPR sequencing content and phage resistance,” says Barrangou, who joined the faculty of North Carolina State University in 2013.

One last bit before getting to the hornless cattle, scientist Yi Li has a November 15, 2018 posting on the GLP website about his work with gene editing and food crops,

I’m a plant geneticist and one of my top priorities is developing tools to engineer woody plants such as citrus trees that can resist the greening disease, Huanglongbing (HLB), which has devastated these trees around the world. First detected in Florida in 2005, the disease has decimated the state’s US$9 billion citrus crop, leading to a 75 percent decline in its orange production in 2017. Because citrus trees take five to 10 years before they produce fruits, our new technique – which has been nominated by many editors-in-chief as one of the groundbreaking approaches of 2017 that has the potential to change the world – may accelerate the development of non-GMO citrus trees that are HLB-resistant.

Genetically modified vs. gene edited

You may wonder why the plants we create with our new DNA editing technique are not considered GMO? It’s a good question.

Genetically modified refers to plants and animals that have been altered in a way that wouldn’t have arisen naturally through evolution. A very obvious example of this involves transferring a gene from one species to another to endow the organism with a new trait – like pest resistance or drought tolerance.

But in our work, we are not cutting and pasting genes from animals or bacteria into plants. We are using genome editing technologies to introduce new plant traits by directly rewriting the plants’ genetic code.

This is faster and more precise than conventional breeding, is less controversial than GMO techniques, and can shave years or even decades off the time it takes to develop new crop varieties for farmers.

There is also another incentive to opt for using gene editing to create designer crops. On March 28, 2018, U.S. Secretary of Agriculture Sonny Perdue announced that the USDA wouldn’t regulate new plant varieties developed with new technologies like genome editing that would yield plants indistinguishable from those developed through traditional breeding methods. By contrast, a plant that includes a gene or genes from another organism, such as bacteria, is considered a GMO. This is another reason why many researchers and companies prefer using CRISPR in agriculture whenever it is possible.

As the Gatropod’casters note, there’s more than one side to the gene editing story and not everyone is comfortable with the notion of cavalierly changing genetic codes when so much is still unknown.

Hornless cattle update

First mentioned here in a November 28, 2018 posting, hornless cattle have been in the news again. From an October 7, 2019 news item on ScienceDaily,

For the past two years, researchers at the University of California, Davis, have been studying six offspring of a dairy bull, genome-edited to prevent it from growing horns. This technology has been proposed as an alternative to dehorning, a common management practice performed to protect other cattle and human handlers from injuries.

UC Davis scientists have just published their findings in the journal Nature Biotechnology. They report that none of the bull’s offspring developed horns, as expected, and blood work and physical exams of the calves found they were all healthy. The researchers also sequenced the genomes of the calves and their parents and analyzed these genomic sequences, looking for any unexpected changes.

An October 7, 2019 UC Davis news release (also on EurekAlert), which originated the news item, provides more detail about the research (I have checked the UC Davis website here and the October 2019 update appears to be the latest available publicly as of February 5, 2020),

All data were shared with the U.S. Food and Drug Administration. Analysis by FDA scientists revealed a fragment of bacterial DNA, used to deliver the hornless trait to the bull, had integrated alongside one of the two hornless genetic variants, or alleles, that were generated by genome-editing in the bull. UC Davis researchers further validated this finding.

“Our study found that two calves inherited the naturally-occurring hornless allele and four calves additionally inherited a fragment of bacterial DNA, known as a plasmid,” said corresponding author Alison Van Eenennaam, with the UC Davis Department of Animal Science.

Plasmid integration can be addressed by screening and selection, in this case, selecting the two offspring of the genome-edited hornless bull that inherited only the naturally occurring allele.

“This type of screening is routinely done in plant breeding where genome editing frequently involves a step that includes a plasmid integration,” said Van Eenennaam.

Van Eenennaam said the plasmid does not harm the animals, but the integration technically made the genome-edited bull a GMO, because it contained foreign DNA from another species, in this case a bacterial plasmid.

“We’ve demonstrated that healthy hornless calves with only the intended edit can be produced, and we provided data to help inform the process for evaluating genome-edited animals,” said Van Eenennaam. “Our data indicates the need to screen for plasmid integration when they’re used in the editing process.”

Since the original work in 2013, initiated by the Minnesota-based company Recombinetics, new methods have been developed that no longer use donor template plasmid or other extraneous DNA sequence to bring about introgression of the hornless allele.

Scientists did not observe any other unintended genomic alterations in the calves, and all animals remained healthy during the study period. Neither the bull, nor the calves, entered the food supply as per FDA guidance for genome-edited livestock.

WHY THE NEED FOR HORNLESS COWS?

Many dairy breeds naturally grow horns. But on dairy farms, the horns are typically removed, or the calves “disbudded” at a young age. Animals that don’t have horns are less likely to harm animals or dairy workers and have fewer aggressive behaviors. The dehorning process is unpleasant and has implications for animal welfare. Van Eenennaam said genome-editing offers a pain-free genetic alternative to removing horns by introducing a naturally occurring genetic variant, or allele, that is present in some breeds of beef cattle such as Angus.

Here’s a link to and a citation for the paper,

Genomic and phenotypic analyses of six offspring of a genome-edited hornless bull by Amy E. Young, Tamer A. Mansour, Bret R. McNabb, Joseph R. Owen, Josephine F. Trott, C. Titus Brown & Alison L. Van Eenennaam. Nature Biotechnology (2019) DOI: https://doi.org/10.1038/s41587-019-0266-0 Published 07 October 2019

This paper is open access.