Tag Archives: Vitor Cabral

Memristors as the new standard for electrical resistance

An October 27, 2025 Polytechnic University of Turin (Politecnico di Torino [PoliTo]) press release announced research into the science of measurement (metrology), Note: Links have been removed,

Tracking electrical resistance is essential to ensure the accuracy and reliability of electrical measurements worldwide. Since 2019, the units of measurement in the International System (SI) are no longer based on standard samples (kilogram, metre, etc.), but are derived from universal constants such as the speed of light. For electrical resistance, reference is therefore made to electrical conductance – which measures the ability of a material to conduct electricity – quantised (G₀) – a combination of Planck’s constant (h) and the elementary charge (e) – typically measured using the quantum Hall effect, a technique that provides accurate and reproducible values but requires expensive cryogenic systems and high-intensity magnetic fields available in only a few national metrology institutes (NMIs).

The study ‘Quantum resistance memristor for International System of Units intrinsically traceable standard’co-authored by a group of researchers from Politecnico di Torino together with leading European metrology centres and published today in the prestigious journal Nature Nanotechnology, introduces a new standard for the traceability of electrical resistance: memristors, nanometric devices capable of modifying their conductivity in response to external stimuli. This is an innovative discovery: memristors can provide stable resistance values that are intrinsically correlated with the fundamental constants of nature, with the possibility of programming the resistance by modifying the silver nanofilaments that characterise them.

These changes can be adjusted at the atomic level even at room temperature, thus generating quantum leaps – fundamental concepts of quantum mechanics referring to the phenomenon whereby a quantum system passes from one energy level to another in a discontinuous manner, i.e. without passing through intermediate states, as happens with an electron in an atom – discrete, corresponding to G0 (or multiples) that can be measured with conventional reading systems. This approach paves the way for the concept of “NMI-on-a-chip”, i.e. the possibility of integrating the functions of an entire national metrology institute at the microchip level.

In the future, electrical measuring devices such as multimeters – among the most widely used instruments in the industry for measuring electrical quantities – could thus have a memristor as a reference for self-calibration, i.e. to automatically adjust their measurement or operating parameters so as to maintain the accuracy and correctness of results without external human intervention. This will enable the use of simplified calibration procedures in industry and in sectors where the portability of calibrated measurements is a necessity.

“The results obtained and published in the prestigious journal Nature Nanotechnology are the fruit of the European MEMQuD project, where fundamental research by academic institutions such as Politecnico di Torino and the Forschungszentrum Jülich on the phenomenon of “electrochemical polishing” (thanks to which nanofilaments can be “filed” at the atomic level) was coupled with the methodological rigour of the national metrology institutes of Italy, Turkey, Spain, Portugal and Germany”, comment the co-authors of the study Carlo Ricciardi and Fabio Michieletti, respectively professor and post-doctoral researcher at the Department of Applied Science and Technology-DISAT and members of the NaMeS group at Politecnico di Torino.

An October 28, 2025 Universitat Autonoma de Barcelona press release (also on EurekAlert but published November 3, 2025) provides additional insight,

Microchips with a memristor could replace an entire electrical resistance calibration laboratory

An international research collaboration with the involvement of the UAB demonstrates for the first time that memristors, electronic devices at the nanoscale,  can easily calibrate electrical resistance for certain applications without requiring large and complex laboratories working at extreme temperatures and very high magnetic fields. The work, published in Nature Nanotechnology, explores for the first time the metrological applications of these devices in calibration procedures of electronic systems.

Measuring electrical resistance with maximum precision to be used as a standard in metrology requires complex laboratories at temperatures close to the absolute zero and magnetic fields that are more intense than those used in clinical magnetic resonance imaging.

International research under the framework of the European project MEMQuD, which included the involvement of UAB Department of Electronic Engineering professors Enrique Miranda and Jordi Suñé, demonstrates that memristors can provide stable resistance values directly linked to fundamental constants of nature. Thus, they can become a new much simpler standard than current systems for calibrations of this magnitude.

Measurement standards based on constants of nature

Since 2019, all base units of the International System of Units (SI)—including the metre, second, and kilogram—have been based on fundamental natural constants. For example, the kilogram, which was once based on the “prototype kilogram,” is now linked to Planck’s constant h. A metre is defined with respect to the speed of light, and a second by the oscillation of the cesium atom.

Thanks to laser interferometers and atomic clocks, units of length and time can be verified relatively easily worldwide. The situation is quite different for physical quantities such as mass and electrical units. Their metrological traceability is so complex that the measurements are feasible only in a handful of national metrology institutes.

Until now, the quantum Hall effect has served as the standard for electrical resistance. While it provides highly precise and reproducible values, it requires extreme laboratory conditions, i.e. temperatures close to absolute zero and high magnetic fields. The measurements require sophisticated cryogenic systems and strictly controlled facilities.

Memristors as standard resistance measurement systems

Memristors offer a radically different approach. Originally developed as building blocks for novel computing architectures, such as non-volatile memories and neuromorphic circuits emulating computations in the brain, they exhibit a switching behavior that directly follows universal constants.

Functionally, they act as programmable resistors—essentially resistors with memory. This resistance can be changed by applying external voltages or currents. Conductive nanofilaments of individual silver atoms forms inside them. By applying electrical bias, these filaments can be adjusted with atomic precision so that their conductance changes not continuously, but in discrete quantum steps.

We have confirmed that memristors can reliably generate discrete resistance states that are directly related to universal constants of nature. In 1998, our group already revealed these quantum effects for the first time in the dielectric breakdown of thin insulators. For certain applications, these devices can be used for calibration without the need of complex cooling systems or high magnetic fields”, says UAB professor Enrique Miranda.

A national metrology institute condensed into one microchip

This approach makes it possible to talk about a concept known as “NMI-in-a-chip”: the service of a national metrology institute condensed into a microchip. In the future, this could mean that a measuring device has its resistance reference built-in directly into the chip. Lengthy calibration chains—from measurements in metrology institutes, reference resistors and precision calibrators, to the calibration of end-user devices—would no longer be necessary. Instead of repeatedly sending a multimeter to the calibration laboratory, it could check itself internally, i.e. a built-in calibration standard.

Applications in research and industries

Applications range from simplified calibration procedures in industry to mobile measuring systems and portable standards for research in the field or in space. “We are at the beginning of a paradigm shift—moving away from complex large-scale facilities towards intrinsic, quantum-accurate standards that can be integrated into any chip”, says UAB professor Jordi Suñé.

Quantified electrical conductance

The foundation of this work is the quantized electrical conductance G₀, derived from Planck’s constant h and the elementary charge e. In the experiments, memristors were reproducibly programmed in air at room temperature into stable conductance states of exactly 1·G₀ and 2·G₀, maintained over extended periods of time. Measurements taken at participating research institutes in Italy, Germany, Spain, Turkey, and Portugal revealed a deviation of 3.8 percent for 1·G₀ and 0.6 percent for 2·G₀. The key lies in a process known as “electrochemical polishing”. In this process, unstable atoms are removed from the conducting filament until only a stable quantized conduction channel remains.

The European project MEMQuD, funded by the European Metrology Programme for Innovation and Research (EMPIR) of the EURAMET alliance of metrology organisations, is an international collaboration with the involvement of the UAB, the INRiM (Italy), the Forschungszentrum Jülich, Peter Grünberg Institute (Germany), the Politecnico di Torino (Italy), the IMDEA Nanociencia (Spain), the TUBITAK National Metrology Institute (Turkey), the TOBB University of Economics and Technology (Turkey), the Instituto Português da Qualidade (Portugal), and the Bulgarian Academy of Sciences (Bulgaria).

Here’s a link to and a citation for the paper,

A quantum resistance memristor for an intrinsically traceable International System of Units standard by Gianluca Milano, Xin Zheng, Fabio Michieletti, Giuseppe Leonetti, Gabriel Caballero, Ilker Oztoprak, Luca Boarino, Özgür Bozat, Luca Callegaro, Natascia De Leo, Isabel Godinho, Daniel Granados, Itir Koymen, Mariela Menghini, Enrique Miranda, Luís Ribeiro, Carlo Ricciardi, Jordi Suñe, Vitor Cabral & Ilia Valov. Nature Nanotechnology volume 20, pages 1884–1890 (2025) Published: 27 October 2025 Version of record: 27 October 2025 Issue date: December 2025 DOI: https://doi.org/10.1038/s41565-025-02037-5

This paper is open access.

Wonders of curcumin: wound healing; wonders of aromatic-turmerone: stem cells

Both curcumin and turmerone are constituents of turmeric which has been long lauded for its healing properties. Michael Berger has written a Nanowerk Spotlight article featuring curcumin and some recent work on burn wound healing. Meanwhile, a ScienceDaily news item details information about a team of researchers focused on tumerone as a means for regenerating brain stem cells.

Curcumin and burn wounds

In a Sept. 22, 2014 Nanowerk Spotlight article Michael Berger sums up the curcumin research effort (referencing some of this previous articles on the topic) in light of a new research paper about burn wound healing (Note: Links have been removed),

Despite significant progress in medical treatments of severe burn wounds, infection and subsequent sepsis persist as frequent causes of morbidity and mortality for burn victims. This is due not only to the extensive compromise of the protective barrier against microbial invasion, but also as a result of growing pathogen resistance to therapeutic options.

… Dr Adam Friedman, Assistant Professor of Dermatology and Director of Dermatologic research at the Montefiore-Albert Einstein College of Medicine, tells Nanowerk. “For me, this gap fuels innovation, serving as the inspiration for my research with broad-spectrum, multi-mechanistic antimicrobial nanomaterials.”

In new work, Friedman and a team of researchers from Albert Einstein College of Medicine and Oregon State University have explored the use of curcumin nanoparticles for the treatment of infected burn wounds, an application that resulted in reduced bacterial load and enhancing wound healing.

It certainly seems promising as per the article abstract,

Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent by Aimee E. Krausz, Brandon L. Adler, Vitor Cabral, Mahantesh Navati, Jessica Doerner, Rabab Charafeddine, Dinesh Chandra, Hongying Liang, Leslie Gunther, Alicea Clendaniel, Stacey Harper, Joel M. Friedman, Joshua D. Nosanchuk, & Adam J. Friedman. Nanomedicine: Nanotechnology, Biology and Medicine (article in press) published online 19 September 2014.http://www.nanomedjournal.com/article/S1549-9634%2814%2900527-9/abstract Uncorrected Proof

Burn wounds are often complicated by bacterial infection, contributing to morbidity and mortality. Agents commonly used to treat burn wound infection are limited by toxicity, incomplete microbial coverage, inadequate penetration, and rising resistance. Curcumin is a naturally derived substance with innate antimicrobial and wound healing properties. Acting by multiple mechanisms, curcumin is less likely than current antibiotics to select for resistant bacteria.

Curcumin’s poor aqueous solubility and rapid degradation profile hinder usage; nanoparticle encapsulation overcomes this pitfall and enables extended topical delivery of curcumin.

In this study, we synthesized and characterized curcumin nanoparticles (curc-np), which inhibited in vitro growth of methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa in dose-dependent fashion, and inhibited MRSA growth and enhanced wound healing in an in vivo murine wound model. Curc-np may represent a novel topical antimicrobial and wound healing adjuvant for infected burn wounds and other cutaneous injuries.

Two things: This paper is behind a paywall and note the use of the term ‘in vivo’ which means they have tested on animals such as rats and mice for example, but not humans. Nonetheless, it seems a promising avenue for further exploration.

Interestingly, there was an attempt in 1995 to patent turmeric for use in wound healing as per my Dec. 26, 2011 posting which featured then current research on turmeric,

There has already been one court case regarding a curcumin patent,

Recently, turmeric came into the global limelight when the controversial patent “Use of Turmeric in Wound Healing” was awarded, in 1995, to the University of Mississippi Medical Center, USA. Indian Council of Scientific and Industrial Research (CSIR) aggressively contested this award of the patent. It was argued by them that turmeric has been an integral part of the traditional Indian medicinal system over several centuries, and therefore, is deemed to be ‘prior art’, hence is in the public domain. Subsequently, after protracted technical/legal battle USPTO decreed that turmeric is an Indian discovery and revoked the patent.

One last bit about curcumin, my April 22, 2014 posting featured work in Iran using curcumin for cancer-healing.

Tumerone

This excerpt from a Sept. 25, 2014, news item in ScienceDaily represents the first time that tumerone has been mentioned here,

A bioactive compound found in turmeric promotes stem cell proliferation and differentiation in the brain, reveals new research published today in the open access journal Stem Cell Research & Therapy. The findings suggest aromatic turmerone could be a future drug candidate for treating neurological disorders, such as stroke and Alzheimer’s disease.

A Sept. 25, 2014 news release on EurekAlert provides more information,

The study looked at the effects of aromatic (ar-) turmerone on endogenous neutral stem cells (NSC), which are stem cells found within adult brains. NSC differentiate into neurons, and play an important role in self-repair and recovery of brain function in neurodegenerative diseases. Previous studies of ar-turmerone have shown that the compound can block activation of microglia cells. When activated, these cells cause neuroinflammation, which is associated with different neurological disorders. However, ar-turmerone’s impact on the brain’s capacity to self-repair was unknown.

Researchers from the Institute of Neuroscience and Medicine in Jülich, Germany, studied the effects of ar-turmerone on NSC proliferation and differentiation both in vitro and in vivo. Rat fetal NSC were cultured and grown in six different concentrations of ar-turmerone over a 72 hour period. At certain concentrations, ar-turmerone was shown to increase NSC proliferation by up to 80%, without having any impact on cell death. The cell differentiation process also accelerated in ar-turmerone-treated cells compared to untreated control cells.

To test the effects of ar-turmerone on NSC in vivo, the researchers injected adult rats with ar-turmerone. Using PET imaging and a tracer to detect proliferating cells, they found that the subventricular zone (SVZ) was wider, and the hippocampus expanded, in the brains of rats injected with ar-turmerone than in control animals. The SVZ and hippocampus are the two sites in adult mammalian brains where neurogenesis, the growth of neurons, is known to occur.

Lead author of the study, Adele Rueger, said: “While several substances have been described to promote stem cell proliferation in the brain, fewer drugs additionally promote the differentiation of stem cells into neurons, which constitutes a major goal in regenerative medicine. Our findings on aromatic turmerone take us one step closer to achieving this goal.”

Ar-turmerone is the lesser-studied of two major bioactive compounds found in turmeric. The other compound is curcumin, which is well known for its anti-inflammatory and neuroprotective properties

Here’s a link to and a citation for the paper,

Aromatic-turmerone induces neural stem cell proliferation in vitro and in vivo by Joerg Hucklenbroich, Rebecca Klein, Bernd Neumaier, Rudolf Graf, Gereon Rudolf Fink, Michael Schroeter, and Maria Adele Rueger. Stem Cell Research & Therapy 2014, 5:100  doi:10.1186/scrt500

This is an open access paper.