Tag Archives: Zhen Yang

European medieval monks, Japanese scribes, and Middle Eastern chroniclers all contributed to volcanology

Volcanoes are not often a topic on this blog, which is focused on emerging science and technology. However, stories featuring scientific information from unexpected sources has long been a fascination of mine and this April 5, 2023 news item on ScienceDaily shines a light on an unusual cast of medieval scientific observers spanning the globe,

By observing the night sky, medieval monks unwittingly recorded some of history’s largest volcanic eruptions. An international team of researchers, led by the University of Geneva (UNIGE), drew on readings of 12th and 13th century European and Middle Eastern chronicles, along with ice core and tree ring data, to accurately date some of the biggest volcanic eruptions the world has ever seen. Their results, reported in the journal Nature, uncover new information about one of the most volcanically active periods in Earth’s history, which some think helped to trigger the Little Ice Age, a long interval of cooling that saw the advance of European glaciers.

llumination from the late 14th or early 15th century, which portrays two individuals observing a lunar eclipse. It features the words «La lune avant est eclipsee», «The moon is eclipsed» in english. © Source gallica.bnf.fr / BnF Courtesy: Université de Genève

An April 5, 2023 Université de Genève (UNIGE) press release (also on EurekAlert), which originated the news item, includes observations from Japanese scribes along with those from medieval European monks and Middle Eastern scholars,

It took the researchers almost five years to examine hundreds of annals and chronicles from across Europe and the Middle East, in search of references to total lunar eclipses and their colouration. Total lunar eclipses occur when the moon passes into the Earth’s shadow. Typically, the moon remains visible as a reddish orb because it is still bathed in sunlight bent round the Earth by its atmosphere. But after a very large volcanic eruption, there can be so much dust in the stratosphere – the middle part of the atmosphere starting roughly where commercial aircraft fly – that the eclipsed moon almost disappears.

Medieval chroniclers recorded and described all kinds of historical events, including the deeds of kings and popes, important battles, and natural disasters and famines. Just as noteworthy were the celestial phenomena that might foretell such calamities. Mindful of the Book of Revelation, a vision of the end times that speaks of a blood-red moon, the monks were especially careful to take note of the moon’s coloration. Of the 64 total lunar eclipses that occurred in Europe between 1100 and 1300, the chroniclers had faithfully documented 51. In five of these cases, they also reported that the moon was exceptionally dark.

The contribution of Japanese scribes 

Asked what made him connect the monks’ records of the brightness and colour of the eclipsed moon with volcanic gloom, the lead author of the work, Sébastien Guillet, senior research associate at the Institute for environmental sciences at the UNIGE,  said: “I was listening to Pink Floyd’s Dark Side of the Moon album when I realised that the darkest lunar eclipses all occurred within a year or so of major volcanic eruptions. Since we know the exact days of the eclipses, it opened the possibility of using the sightings to narrow down when the eruptions must have happened.”

The researchers found that scribes in Japan took equal note of lunar eclipses. One of the best known, Fujiwara no Teika, wrote of an unprecedented dark eclipse observed on 2 December 1229: ‘the old folk had never seen it like this time, with the location of the disk of the Moon not visible, just as if it had disappeared during the eclipse… It was truly something to fear.’ The stratospheric dust from large volcanic eruptions was not only responsible for the vanishing moon. It also cooled summer temperatures by limiting the sunlight reaching the Earth’s surface. This in turn could bring ruin to agricultural crops.

Cross-checking text and data 

“We know from previous work that strong tropical eruptions can induce global cooling on the order of roughly 1°C over a few years,” said Markus Stoffel, full professor at the Institute for environmental sciences at the UNIGE and last author of the study, a specialist in converting measurements of tree rings into climate data, who co-designed the study. “They can also lead to rainfall anomalies with droughts in one place and floods in another.”

Despite these effects, people at the time could not have imagined that the poor harvests or the unusual lunar eclipses had anything to do with volcanoes – the eruptions themselves were all but one undocumented. “We only knew about these eruptions because they left traces in the ice of Antarctica and Greenland,” said co-author Clive Oppenheimer, professor at the Department of Geography at the University of Cambridge. “By putting together the information from ice cores and the descriptions from medieval texts we can now make better estimates of when and where some of the biggest eruptions of this period occurred.”

Climate and society affected 

To make the most of this integration, Sébastien Guillet worked with climate modellers to compute the most likely timing of the eruptions. “Knowing the season when the volcanoes erupted is essential, as it influences the spread of the volcanic dust and the cooling and other climate anomalies associated with these eruptions,” he said.

As well as helping to narrow down the timing and intensity of these events, what makes the findings significant is that the interval from 1100 to 1300 is known from ice core evidence to be one of the most volcanically active periods in history. Of the 15 eruptions considered in the new study, one in the mid-13th century rivals the famous 1815 eruption of Tambora that brought on ‘the year without a summer’ of 1816. The collective effect of the medieval eruptions on Earth’s climate may have led to the Little Ice Age, when winter ice fairs were held on the frozen rivers of Europe. “Improving our knowledge of these otherwise mysterious eruptions, is crucial to understanding whether and how past volcanism affected not only climate but also society during the Middle Ages,” concludes the researcher.

Here’s a link to and a citation for the paper,

Lunar eclipses illuminate timing and climate impact of medieval volcanism by Sébastien Guillet, Christophe Corona, Clive Oppenheimer, Franck Lavigne, Myriam Khodri, Francis Ludlow, Michael Sigl, Matthew Toohey, Paul S. Atkins, Zhen Yang, Tomoko Muranaka, Nobuko Horikawa & Markus Stoffel. Nature volume 616, pages 90–95 (2023) Issue Date: 06 April 2023 DOI: https://doi.org/10.1038/s41586-023-05751-z Published online: 05 April 2023

This paper is open access.

Making longer lasting bandages with sound and bubbles

This research into longer lasting bandages described in an August 12, 2022 news item on phys.org comes from McGill University (Montréal, Canada)

Researchers have discovered that they can control the stickiness of adhesive bandages using ultrasound waves and bubbles. This breakthrough could lead to new advances in medical adhesives, especially in cases where adhesives are difficult to apply such as on wet skin.

“Bandages, glues, and stickers are common bioadhesives that are used at home or in clinics. However, they don’t usually adhere well on wet skin. It’s also challenging to control where they are applied and the strength and duration of the formed adhesion,” says McGill University Professor Jianyu Li, who led the research team of engineers, physicists, chemists, and clinicians.

Caption: Adhesive hydrogel applied on skin under ultrasound probe. Credit: Ran Huo and Jianyu Li

An August 12, 2022 McGill University news release (also on EurekAlert), which originated the news item, delves further into the work,

“We were surprised to find that by simply playing around with ultrasonic intensity, we can control very precisely the stickiness of adhesive bandages on many tissues,” says lead author Zhenwei Ma, a former student of Professor Li and now a Killam Postdoctoral Fellow at the University of British Columbia.

Ultrasound induced bubbles control stickiness

In collaboration with physicists Professor Outi Supponen and Claire Bourquard from the Institute of Fluid Dynamics at ETH Zurich, the team experimented with ultrasound induced microbubbles to make adhesives stickier. “The ultrasound induces many microbubbles, which transiently push the adhesives into the skin for stronger bioadhesion,” says Professor Supponen. “We can even use theoretical modeling to estimate exactly where the adhesion will happen.”

Their study, published in the journal Science, shows that the adhesives are compatible with living tissue in rats. The adhesives can also potentially be used to deliver drugs through the skin. “This paradigm-shifting technology will have great implications in many branches of medicine,” says University of British Columbia Professor Zu-hua Gao. “We’re very excited to translate this technology for applications in clinics for tissue repair, cancer therapy, and precision medicine.”

“By merging mechanics, materials and biomedical engineering, we envision the broad impact of our bioadhesive technology in wearable devices, wound management, and regenerative medicine,” says Professor Li, who is also a Canada Research Chair in Biomaterials and Musculoskeletal Health.

Here’s a link to and a citation for the paper,

Controlled tough bioadhesion mediated by ultrasound by Zhenwei Ma, Claire Bourquard, Qiman Gao, Shuaibing Jiang, Tristan De Iure-Grimmel, Ran Huo, Xuan Li, Zixin He, Zhen Yang, Galen Yang, Yixiang Wang, Edmond Lam, Zu-hua Gao, Outi Supponen and Jianyu Li. Science 11 Aug 2022 Vol 377, Issue 6607 pp. 751-755 DOI: 10.1126/science.abn8699

This paper is behind a paywall.

I haven’t seen this before but it seems that one of the journal’s editors decided to add a standalone paragraph to hype some of the other papers about adhesives in the issue,

A sound way to make it stick

Tissue adhesives play a role in temporary or permanent tissue repair, wound management, and the attachment of wearable electronics. However, it can be challenging to tailor the adhesive strength to ensure reversibility when desired and to maintain permeability. Ma et al. designed hydrogels made of polyacrylamide or poly(N-isopropylacrylamide) combined with alginate that are primed using a solution containing nanoparticles of chitosan, gelatin, or cellulose nanocrystals (see the Perspective by Es Sayed and Kamperman). The application of ultrasound causes cavitation that pushes the primer molecules into the tissue. The mechanical interlocking of the anchors eventually results in strong adhesion between hydrogel and tissue without the need for chemical bonding. Tests on porcine or rat skin showed enhanced adhesion energy and interfacial fatigue resistance with on-demand detachment. —MSL

I like the wordplay and am guessing that MSL is:

Marc S. Lavine
Senior Editor
Education: BASc, University of Toronto; PhD, University of Cambridge
Areas of responsibility: Reviews; materials science, biomaterials, engineering

Extracting biomolecules from live cells with carbon nanotubes

Being able to extract biomolecules from living cells means nondestruction of the rest of the cell and the ability to observe the consequences of the extraction. From a July 18, 2014 news item on Azonano,

University of Houston researchers have devised a new method for extracting molecules from live cells without disrupting cell development, work that could provide new avenues for the diagnosis of cancer and other diseases.

The researchers used magnetized carbon nanotubes to extract biomolecules from live cells, allowing them to retrieve molecular information without killing the individual cells. A description of the work appears this week in the Proceedings of the National Academy of Sciences.

A July 16, 2014 University of Houston news release by Jeannie Kever, which originated the news item, provides more detail,

Most current methods of identifying intracellular information result in the death of the individual cells, making it impossible to continue to gain information and assess change over time, said Zhifeng Ren, M.D. Anderson Chair professor of physics and principal investigator at the Center for Superconductivity at UH and lead author of the paper. The work was a collaboration between Ren’s lab and that of Paul Chu, T.L.L. Temple Chair of Science and founding director of the Texas Center for Superconductivity.

Chu, a co-author of the paper, said the new technique will allow researchers to draw fundamental information from a single cell.The researchers said the steps outlined in the paper offer proof of concept. Ren said the next step “will be more study of the biological and chemical processes of the cell, more analysis.”

The initial results hold promise for biomedicine, he said.  “This shows how nanoscience and nanoengineering can help the medical field.”

Cai said the new method will be helpful for cancer drug screening and carcinogenesis study, as well as for studies that allow researchers to obtain information from single cells, replacing previous sampling methods that average out cellular diversity and obscure the specificity of the biomarker profiles.

In the paper, the researchers explain their rationale for the work – most methods for extracting molecular information result in cell death, and those that do spare the cell carry special challenges, including limited efficiency.

This method is relatively straightforward, requiring the use of magnetized carbon nanotubes as the transporter and a polycarbonate filter as a collector, they report. Cells from a human embryonic kidney cancer cell line were used for the experiment.

The work builds on a 2005 paper published by Ren’s group in Nature Methods, which established that magnetized carbon nanotubes can deliver molecular payloads into cells. The current research takes that one step further to move molecules out of cells by magnetically driving them through the cell walls.

The carbon nanotubes were grown with a plasma-enhanced chemical vapor deposition system, with magnetic nickel particles enclosed at the tips. A layer of nickel was also deposited along the surface of individual nanotubes in order to make the nanotubes capable of penetrating a cell wall guided by a magnet.

Here’s a link to and a citation for the paper,

Molecular extraction in single live cells by sneaking in and out magnetic nanomaterials by Zhen Yang, Liangzi Deng, Yucheng Lan, Xiaoliu Zhang, Zhonghong Gao, Ching-Wu Chu, Dong Cai, and Zhifeng Ren. PNAS 2014 ; published ahead of print July 16, 2014, doi:10.1073/pnas.1411802111

This paper is behind a paywall.